1,780 results match your criteria Cancer Cell International [Journal]


Knockdown of lncRNA PVT1 inhibits prostate cancer progression in vitro and in vivo by the suppression of KIF23 through stimulating miR-15a-5p.

Cancer Cell Int 2020 2;20:283. Epub 2020 Jul 2.

Department of Urology Surgery, The Huaihe Hospital of Henan University, Kaifeng, Henan China.

Background: Prostate cancer (PCa) greatly threatens men's lives, with high incidence and mortality. Recently, the research of long non-coding RNAs (lncRNAs) has made breakthroughs in the development of human cancers. This study aimed to figure out the role and action mechanism of lncRNA PVT1 (PVT1) in PCa. Read More

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http://dx.doi.org/10.1186/s12935-020-01363-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330980PMC

Correction to: Identification of a competing endogenous RNA network associated with prognosis of pancreatic adenocarcinoma.

Cancer Cell Int 2020 1;20:282. Epub 2020 Jul 1.

Department of Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang People's Republic of China.

[This corrects the article DOI: 10.1186/s12935-020-01243-6.]. Read More

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http://dx.doi.org/10.1186/s12935-020-01381-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329454PMC

Genomic profiling of colorectal cancer with isolated lung metastasis.

Cancer Cell Int 2020 1;20:281. Epub 2020 Jul 1.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142 China.

Background: Metastasis is a major cause of failed colorectal cancer (CRC) treatment. While lung metastasis (LM) is observed in 10-15% of patients with CRC, the genetic mechanisms that cause CRC to metastasize to the lung remain unclear.

Methods: In this study, we employed whole exome sequencing (WES) of primary CRC tumors and matched isolated LM lesions to compare their genomic profiles. Read More

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http://dx.doi.org/10.1186/s12935-020-01373-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329491PMC

Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells.

Cancer Cell Int 2020 1;20:280. Epub 2020 Jul 1.

Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY USA.

Background: Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, leading to uncontrolled cell proliferation. Palbociclib, a small molecule inhibitor of CDK4/6, has shown anti-tumor activity in vitro and in vivo, with recent studies demonstrating a functional role for palbociclib in reprogramming cellular metabolism. Read More

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http://dx.doi.org/10.1186/s12935-020-01357-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329430PMC

Systematic profiling of alternative splicing in -negative gastric cancer and their clinical significance.

Cancer Cell Int 2020 30;20:279. Epub 2020 Jun 30.

Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001 Liaoning China.

Background: Alternative splicing (AS) may cause structural and functional variations in the protein to promote the proliferation of tumor cells. However, there is no comprehensive analysis of the clinical significance of AS in -negative gastric cancer (HP GC).

Methods: The clinical, gene expression profile data and AS events of 138 HP GC patients were obtained from the database named the cancer genome atlas. Read More

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http://dx.doi.org/10.1186/s12935-020-01368-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325377PMC

Cytotoxicity study of the interleukin-12-expressing recombinant Newcastle disease virus strain, rAF-IL12, towards CT26 colon cancer cells in vitro and in vivo.

Cancer Cell Int 2020 29;20:278. Epub 2020 Jun 29.

Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan 43400 Malaysia.

Background: Oncolytic viruses have emerged as an alternative therapeutic modality for cancer as they can replicate specifically in tumour cells and induce toxic effects leading to apoptosis. Despite the great potentials and promising results shown in multiple studies, it appears that their efficacy is still moderate and deemed as not sufficient in clinical studies. In addressing this issue, genetic/molecular engineering approach has paved its way to improve the therapeutic efficacy as observed in the case of herpes simplex virus (HSV) expressing granulocyte-macrophage colony-stimulating factor (GM-CSF). Read More

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http://dx.doi.org/10.1186/s12935-020-01372-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325054PMC

Flaming the fight against cancer cells: the role of microRNA-93.

Cancer Cell Int 2020 29;20:277. Epub 2020 Jun 29.

Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

There have been attempts to develop novel anti-tumor drugs in cancer therapy. Although satisfying results have been observed at a consequence of application of chemotherapeutic agents, the cancer cells are capable of making resistance into these agents. This has forced scientists into genetic manipulation as genetic alterations are responsible for generation of a high number of cancer cells. Read More

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http://dx.doi.org/10.1186/s12935-020-01349-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325196PMC

Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA).

Cancer Cell Int 2020 26;20:276. Epub 2020 Jun 26.

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050 China.

Background: As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs).

Methods: LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immune infiltration landscape of BLCA was conducted via ssGSEA and immunotherapy response was calculated through TIDE algorithm. Read More

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http://dx.doi.org/10.1186/s12935-020-01362-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320553PMC

LncRNA LINC00261 overexpression suppresses the growth and metastasis of lung cancer via regulating miR-1269a/FOXO1 axis.

Cancer Cell Int 2020 26;20:275. Epub 2020 Jun 26.

Department of Respiratory Medicine, Henan Provincial Chest Hospital, No.1, Weiwu Road, Zhengzhou, 450000 Henan Province China.

Background: LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC).

Methods: Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1186/s12935-020-01332-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318380PMC

LINC01094 triggers radio-resistance in clear cell renal cell carcinoma via miR-577/CHEK2/FOXM1 axis.

Cancer Cell Int 2020 24;20:274. Epub 2020 Jun 24.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Jing'an District, Shanghai, 200072 China.

Background: Radioresistance is an obstacle to limit efficacy of radiotherapy. Meanwhile, long non-coding RNAs (lncRNAs) have been reported to affect radioresistance. Here, we aimed to investigate lncRNAs involving radioresistance development of clear cell renal cell carcinoma (ccRCC), the most frequent type of renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1186/s12935-020-01306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315499PMC

Identification of four hub genes as promising biomarkers to evaluate the prognosis of ovarian cancer in silico.

Cancer Cell Int 2020 24;20:270. Epub 2020 Jun 24.

Cytoskeleton Research Group & First Clinical Medicine College, Nanjing Medical University, No. 101 Longmian Road, Nanjing, 211166 China.

Background: Ovarian cancer (OvCa) is one of the most fatal cancers among females in the world. With growing numbers of individuals diagnosed with OvCa ending in deaths, it is urgent to further explore the potential mechanisms of OvCa oncogenesis and development and related biomarkers.

Methods: The gene expression profiles of GSE49997 were downloaded from the Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.1186/s12935-020-01361-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315561PMC

Knockdown of ALPK2 inhibits the development and progression of Ovarian Cancer.

Cancer Cell Int 2020 24;20:267. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, 410013 Hunan China.

Background: Alpha protein kinase 2 (ALPK2) was known to play a vital role in cancer by regulating cell cycle and DNA repair. Ovarian cancer (OC) is one of the most lethal malignancies in the female reproductive system. The emphasis of this study is to explore the role of ALPK2 in OC. Read More

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http://dx.doi.org/10.1186/s12935-020-01347-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313216PMC

LncRNA FTX represses the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via regulating the M1/M2 polarization of Kupffer cells.

Cancer Cell Int 2020 24;20:266. Epub 2020 Jun 24.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province China.

Background: The effect of lncRNA FTX on non-alcoholic fatty liver disease (NAFLD) conversion to hepatocellular carcinoma (HCC) is unclear.

Methods: In our study, C57BL/6 mice was fed with high fat diet for obtaining NAFLD mouse model, and diethylnitrosamine induced the formation of HCC tumor. The expression of iNOS and CD206 in tissues were examined using immunohistochemistry. Read More

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http://dx.doi.org/10.1186/s12935-020-01354-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315496PMC

Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer.

Cancer Cell Int 2020 24;20:273. Epub 2020 Jun 24.

Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing, 210011 Jiangsu China.

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment. Numerous studies revealed the central role of HIF-1α in the carcinogenesis and progression of pancreatic cancer. Read More

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http://dx.doi.org/10.1186/s12935-020-01370-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313137PMC

Activation of the LINC00242/miR-141/FOXC1 axis underpins the development of gastric cancer.

Cancer Cell Int 2020 24;20:272. Epub 2020 Jun 24.

Department of General Surgery, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), No.79 Kangning Road, Xiangzhou District, Zhuhai, 519000 Guangdong China.

Background: Long non-coding RNAs (LncRNAs) are a class of newly identified transcripts recognized as critical governors of gene expression during human carcinogenesis, whereas their tumor-suppressive or tumor-promoting effects on gastric cancer (GC) are required for further investigation. In the study, we identify the expression pattern of a novel lncRNA LINC00242 in GC and its possible permissive role in the development of GC.

Methods: The study included 68 pairs of GC and adjacent normal gastric tissue samples. Read More

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http://dx.doi.org/10.1186/s12935-020-01369-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313095PMC

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB.

Cancer Cell Int 2020 24;20:271. Epub 2020 Jun 24.

Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics, Ministry of Education, Key Laboratory of Major Diseases in Children, Ministry of Education, Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045 China.

Background: Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood. In the present study, we demonstrate a critical role of β-catenin-NF-κB-FPGS pathway in MTX resistance in the human T-lineage ALL cell lines.

Methods: Lentivirus sh-β-catenin was used to silence the expression of β-catenin. Read More

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http://dx.doi.org/10.1186/s12935-020-01364-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313175PMC

Untargeted LC-MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate.

Cancer Cell Int 2020 24;20:269. Epub 2020 Jun 24.

Department of Orthopedics, the Fourth Affiliated Hospital of China Medical University, Chongshan Road, Shenyang, 110032 Liaoning People's Republic of China.

Background: Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics feature of OSC is not clarified.

Materials And Methods: OSC was isolated by using sphere forming assay and identified. Read More

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http://dx.doi.org/10.1186/s12935-020-01356-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313215PMC

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis.

Cancer Cell Int 2020 24;20:268. Epub 2020 Jun 24.

Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Heping District, Shenyang, 110004 Liaoning China.

Background: Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains unclear. It's meaningful to explore lncRNAs signature for providing prognostic value of EC. Read More

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http://dx.doi.org/10.1186/s12935-020-01359-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313119PMC

The emerging roles of circular RNAs in ovarian cancer.

Cancer Cell Int 2020 23;20:265. Epub 2020 Jun 23.

Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi, 214023 China.

Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Read More

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http://dx.doi.org/10.1186/s12935-020-01367-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313187PMC

Exploring TCGA database for identification of potential prognostic genes in stomach adenocarcinoma.

Cancer Cell Int 2020 23;20:264. Epub 2020 Jun 23.

Beijing Key Laboratory for Tumor Invasion and Metastasis, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069 China.

Background: Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer in the world and ranks third among cancer-related deaths worldwide. The tumour microenvironment (TME) plays an important role in tumorigenesis, development, and metastasis. Hence, we calculated the immune and stromal scores to find the potential prognosis-related genes in STAD using bioinformatics analysis. Read More

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http://dx.doi.org/10.1186/s12935-020-01351-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310509PMC

Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells.

Cancer Cell Int 2020 23;20:263. Epub 2020 Jun 23.

Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193 Japan.

Background: The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are therefore, suggested to play a role in tumor-induced platelet activation, which in turn triggers epithelial-to-mesenchymal transition (EMT) and enhances the invasive and metastatic activities of tumor cells. In addition, as forced PDPN expression itself can alter the propensity of certain tumor cells in favor of EMT and enhance their invasive ability, it is also considered to be involved in the cell signaling system. Read More

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http://dx.doi.org/10.1186/s12935-020-01328-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310449PMC

Identification of key biomarkers associated with cell adhesion in multiple myeloma by integrated bioinformatics analysis.

Cancer Cell Int 2020 22;20:262. Epub 2020 Jun 22.

Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157, 5th West Road, 710004 Xi'an, Shaanxi China.

Background: Multiple Myeloma (MM) is a hematologic malignant disease whose underlying molecular mechanism has not yet fully understood. Generally, cell adhesion plays an important role in MM progression. In our work, we intended to identify key genes involved in cell adhesion in MM. Read More

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http://dx.doi.org/10.1186/s12935-020-01355-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309988PMC

CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis.

Cancer Cell Int 2020 22;20:261. Epub 2020 Jun 22.

Department of Oncology, The Third Affiliated Hospital of Soochow University (Changzhou Tumor Hospital Affiliated to Soochow University), No. 68, Honghe Road, Changzhou, 213000 Jiangsu China.

Background: Circular RNA downstream neighbor of SON (circDONSON) has been revealed to promote gastric cancer (GC) growth and invasion, while the role and molecular mechanism underlying circDONSON in GC cisplatin (DDP) resistance remain unclear.

Methods: Levels of circDONSON, microRNA (miR)-802, and B lymphoma Mo-MLV insertion region 1 (BMI1) mRNA were detected using quantitative real-time polymerase chain reaction. Cell viability and apoptosis were measured by cell counting kit-8 assay, colony formation assay and flow cytometry, respectively. Read More

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http://dx.doi.org/10.1186/s12935-020-01358-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310092PMC

Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer.

Cancer Cell Int 2020 22;20:260. Epub 2020 Jun 22.

Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou, 215004 Jiangsu China.

Background: Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summarize the global prognostic roles of KLKs for survival in CRC patients.

Methods: Eligible published studies were identified by searching electronic databases with several search strategies. Read More

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http://dx.doi.org/10.1186/s12935-020-01350-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310231PMC

Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma.

Cancer Cell Int 2020 22;20:259. Epub 2020 Jun 22.

Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Chengde Medical College, Chengde, 067000 China.

Background: Osteosarcoma (OS) is a common malignant bone tumor originating in the interstitial tissues and occurring mostly in adolescents and young adults. Energy metabolism is a prerequisite for cancer cell growth, proliferation, invasion, and metastasis. However, the gene signatures associated with energy metabolism and their underlying molecular mechanisms that drive them are unknown. Read More

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http://dx.doi.org/10.1186/s12935-020-01352-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310058PMC

MiR-223 regulates autophagy associated with cisplatin resistance by targeting FBXW7 in human non-small cell lung cancer.

Cancer Cell Int 2020 19;20:258. Epub 2020 Jun 19.

Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, No.234, Gucui Road, Hangzhou, 310012 Zhejiang China.

Background: Cisplatin is widely used as a first-line treatment for non-small cell lung cancer (NSCLC), but chemoresistance remains a major clinical obstacle for efficient use. As a microRNA, miR-223 was reported to promote the doxorubicin resistance of NSCLC. However, whether miR-223 is also involved in cisplatin resistance of NSCLC and the mechanism miR-223 involved in drug resistance is unclear. Read More

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http://dx.doi.org/10.1186/s12935-020-01284-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304223PMC

The prognostic value of ITGA and ITGB superfamily members in patients with high grade serous ovarian cancer.

Cancer Cell Int 2020 18;20:257. Epub 2020 Jun 18.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, 200011 China.

Background: Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression of integrin family members were linked to the prognosis of various cancers. However, the role of integrins in predicting progression and prognosis of ovarian cancer patients are still largely elusive. This study is aimed to explore the prognostic values of ITGA and ITGB superfamily members in high grade serous ovarian cancers (HGSOC). Read More

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http://dx.doi.org/10.1186/s12935-020-01344-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301525PMC
June 2020
1.989 Impact Factor

A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.

Cancer Cell Int 2020 18;20:256. Epub 2020 Jun 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410000 Hunan China.

Background: Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma.

Methods: We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformatics analysis, western blot, cell viability, cell cycle and apoptosis and xenograft tumor model as well as immunohistochemical staining. Pull-down and in vitro kinase assay were used to demonstrate Lj-1-60 targeting Fyn. Read More

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http://dx.doi.org/10.1186/s12935-020-01336-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302361PMC

DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups.

Cancer Cell Int 2020 17;20:255. Epub 2020 Jun 17.

Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 DaHua Road, Dong Dan, Beijing, 100730 China.

Background: Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics has been gained, providing new opportunities for cancer detection and treatment.

Methods: We identified prognostic methylation sites based on DNA methylation profiles of BCA in the TCGA database and constructed a specific prognostic subgroup. Read More

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http://dx.doi.org/10.1186/s12935-020-01345-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302382PMC

MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma.

Cancer Cell Int 2020 17;20:254. Epub 2020 Jun 17.

Department of Information Sciences, Tehran University of Medical Sciences, Tehran, Iran.

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e. Read More

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http://dx.doi.org/10.1186/s12935-020-01342-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302353PMC

Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model.

Cancer Cell Int 2020 17;20:253. Epub 2020 Jun 17.

Department of Medical Oncology and Therapeutics Research, Beckman Research Institute, City of Hope National Medical Center, 1218 S Fifth Ave, Monrovia, CA 91016 USA.

Background: CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) breast cancer. However, cancers can advance due to drug resistance, a problem in which tumor heterogeneity and evolution are key features.

Methods: Ribociclib-resistant HR+/HER2- CAMA-1 breast cancer cells were generated through long-term ribociclib treatment. Read More

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http://dx.doi.org/10.1186/s12935-020-01337-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301982PMC

Long non-coding RNA SNHG22 facilitates the malignant phenotypes in triple-negative breast cancer via sponging miR-324-3p and upregulating SUDS3.

Cancer Cell Int 2020 17;20:252. Epub 2020 Jun 17.

The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, West Huan-Hu Rd., Ti Yuan Bei, Hexi District, Tianjin, 300060 People's Republic of China.

Background: Increasing evidence has indicated the important role of long non-coding RNAs (lncRNAs) in regulating the development and progression of cancers, including triple-negative breast cancer (TNBC). Small nucleolar RNA host gene 22 (SNHG22) is a novel lncRNA that has been identified as tumor-contributor in ovarian carcinoma. However, its function has not been explored in TNBC. Read More

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http://dx.doi.org/10.1186/s12935-020-01321-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302359PMC

Random-forest algorithm based biomarkers in predicting prognosis in the patients with hepatocellular carcinoma.

Cancer Cell Int 2020 17;20:251. Epub 2020 Jun 17.

Lanzhou University Second Hospital, Lanzhou, 730030 Gansu China.

Background: Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. The purpose of our study was to investigate the related genes of HCC and discover their potential abilities to predict the prognosis of the patients.

Methods: We obtained RNA sequencing data of HCC from The Cancer Genome Atlas (TCGA) database and performed analysis on protein coding genes. Read More

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http://dx.doi.org/10.1186/s12935-020-01274-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302385PMC

Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress.

Cancer Cell Int 2020 17;20:250. Epub 2020 Jun 17.

Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127 China.

Background: Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have a high relapse rate and poor prognosis. This study aims to explore the underlying mechanism of combining Gilteritinib with ATO at low concentration in the treatment of FLT3-ITD positive leukemias.

Methods: We used both in vitro and in vivo studies to investigate the effects of combination of Gilteritinib with ATO at low concentration on FLT3-ITD positive leukemias, together with the underlying molecular mechanisms of these processes. Read More

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http://dx.doi.org/10.1186/s12935-020-01341-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298957PMC

LncRNA ZFAS1 promotes pancreatic adenocarcinoma metastasis via the RHOA/ROCK2 pathway by sponging miR-3924.

Cancer Cell Int 2020 16;20:249. Epub 2020 Jun 16.

Department of Hepatobiliary and Pancreatic Surgery, Hunnan Division of The First Affiliated Hospital of China Medical University, Liaoning, China.

Background: The mortality and morbidity rates of pancreatic adenocarcinoma have been increasing over the past two decades, and an understanding of the mechanisms underlying pancreatic adenocarcinoma progression is urgently needed. The long non-coding RNA ZFAS1 has been demonstrated to be an oncogene in some cancers, but its function and mechanism in pancreatic adenocarcinoma remain unclear.

Methods: The ZFAS1 expression level in pancreatic adenocarcinoma was predicted by bioinformatic analysis, and the expression level of ZFAS1 in pancreatic adenocarcinoma tissue samples and cell lines was further detected by quantitative real-time PCR and in situ hybridization. Read More

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http://dx.doi.org/10.1186/s12935-020-01322-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298847PMC

CircHIPK3 promotes proliferation and metastasis and inhibits apoptosis of renal cancer cells by inhibiting MiR-485-3p.

Cancer Cell Int 2020 16;20:248. Epub 2020 Jun 16.

Department of Urology, Quanzhou First Hospital Affiliated to Fujian Medical University, 248-252 East Street, Licheng District, Quanzhou, 362002 Fujian Province China.

Background: The intervention of circHIPK3 in renal carcinoma (RC) has not been reported, and thus, the current study investigated the intervention and mechanism of circHIPK3 in RC.

Methods: The expression of circHIPK3 in RC tissues and cells was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Ribonuclease R (RNase R) resistance and distribution of circHIPK3 and HIPK3 were analyzed by RNase R digestion experiments and cytoplasm/nucleus separation experiments. Read More

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http://dx.doi.org/10.1186/s12935-020-01319-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298839PMC

Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion.

Cancer Cell Int 2020 16;20:247. Epub 2020 Jun 16.

Medical Oncology Dept.3, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, No. 99 Longcheng Street, Taiyuan, Shanxi China.

Background: Circular RNAs (circRNAs), a subgroup of non-coding RNAs, are recognized as pivotal mediators in various types of cancers. CircRNA_0000284 (circ_0000284) was manifested to participate in the development of non-small cell lung cancer (NSCLC). The novel functional mechanism of circ_0000284 in NSCLC was investigated in our current study. Read More

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http://dx.doi.org/10.1186/s12935-020-01310-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298744PMC
June 2020
1.989 Impact Factor

Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis.

Cancer Cell Int 2020 16;20:246. Epub 2020 Jun 16.

Edinburgh University Joint Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang China.

Background: Matrine has been reported to exert anti-tumor effects in multiple types of cancers containing hepatocellular carcinoma (HCC). However, the anti-tumor molecular mechanisms of matrine in HCC is still not fully revealed.

Methods: Cell viability, apoptosis, cycle, migration and invasion were determined by Cell counting kit-8 (CCK-8), Flow cytometry and Transwell assays, respectively. Read More

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http://dx.doi.org/10.1186/s12935-020-01293-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296946PMC
June 2020
1.989 Impact Factor

FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells.

Cancer Cell Int 2020 16;20:245. Epub 2020 Jun 16.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei China.

Background: Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex with specificity for high-mannose glycoproteins. The aim of the present study was to investigate the critical role of FBXO2 in OS cells. Read More

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http://dx.doi.org/10.1186/s12935-020-01326-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296666PMC

Knockdown of LINC00662 represses AK4 and attenuates radioresistance of oral squamous cell carcinoma.

Cancer Cell Int 2020 16;20:244. Epub 2020 Jun 16.

Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang China.

Background: LncRNAs play crucial roles in the development of carcinomas. However, the investigation of LINC00662 in Oral squamous cell carcinoma (OSCC) is still elusive.

Methods: qRT-PCR assay tested the expression levels of LINC00662, hnRNPC and AK4. Read More

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http://dx.doi.org/10.1186/s12935-020-01286-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296632PMC

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers.

Cancer Cell Int 2020 15;20:243. Epub 2020 Jun 15.

NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063 Jiangsu China.

Background: Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active anticancer drug 5-Fluorouracil (5-FU). Vaccinia virus armed with the prodrug-activator CD gene would result in augmented antitumor effects that combined the effect of vaccinia virus and 5-FU together, and particularly limited the anticancer drug to tumor regions. Read More

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http://dx.doi.org/10.1186/s12935-020-01340-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296660PMC

MIAT inhibits proliferation of cervical cancer cells through regulating miR-150-5p.

Cancer Cell Int 2020 15;20:242. Epub 2020 Jun 15.

Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Background: To characterize the MIAT expression in cervical cancer and elucidate its mechanistic involvement in the tumor biology of this disease.

Methods: The relative expression of MIAT and miR-150 was determined by real-time PCR. Cell proliferation was measured by the CCK-8 and clonogenic assay. Read More

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http://dx.doi.org/10.1186/s12935-020-01338-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296772PMC

Circ_LDLR promoted the development of papillary thyroid carcinoma via regulating miR-195-5p/LIPH axis.

Cancer Cell Int 2020 15;20:241. Epub 2020 Jun 15.

Department of Gastrointestinal & Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021 Guangxi China.

Background: Emerging studies have demonstrated that circular RNAs (circRNAs) are key regulators for tumorigenesis in cancers, including papillary thyroid carcinoma (PTC). In this study, we aimed to explore the effects of circ_LDLR on PTC.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine the levels of circ_LDLR, miR-195-5p and lipase H (LIPH). Read More

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http://dx.doi.org/10.1186/s12935-020-01327-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296738PMC
June 2020
1.989 Impact Factor

A novel risk score system of immune genes associated with prognosis in endometrial cancer.

Cancer Cell Int 2020 15;20:240. Epub 2020 Jun 15.

Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032 China.

Background: Endometrial cancer was the commonest gynecological malignancy in developed countries. Despite striking advances in multimodality management, however, for patients in advanced stage, targeted therapy still remained a challenge. Our study aimed to investigate new biomarkers for endometrial cancer and establish a novel risk score system of immune genes in endometrial cancer. Read More

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http://dx.doi.org/10.1186/s12935-020-01317-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294624PMC

Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis.

Cancer Cell Int 2020 15;20:239. Epub 2020 Jun 15.

Department of Laboratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071 China.

Background: The incidence and mortality of melanoma is increasing around the world. To deeply explain the mechanism insight into it, we conducted a systematic analysis to examine the levels of regulatory genes of the common RNA epigenetic modification-N6-methyladenosine (mA) in patients with melanoma compared by the healthy.

Methods: We analyzed the expression of mA Eraser, Writer, and Reader genes based on publicly available datasets on Oncomine and validated the results with a gene expression omnibus dataset. Read More

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http://dx.doi.org/10.1186/s12935-020-01309-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294677PMC

The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers.

Cancer Cell Int 2020 12;20:238. Epub 2020 Jun 12.

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001 Liaoning People's Republic of China.

Background: Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN family members, and diagnosis as well as the prognosis of digestive tract cancers.

Methods: Oncomine and Ualcan were used to analyze PTPN expressions. Read More

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http://dx.doi.org/10.1186/s12935-020-01315-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291430PMC

miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.

Cancer Cell Int 2020 12;20:237. Epub 2020 Jun 12.

Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029 China.

Background: The aberrant expression of microRNA-454 (miR-454) has been confirmed to be involved in the development of cancers. However, the functional role of miR-454 in the progression of ovarian cancer remains unclear.

Methods: The expression of miR-454 in ovarian cancer cells and serum of ovarian cancer patients was detected by RT-PCR. Read More

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http://dx.doi.org/10.1186/s12935-020-01300-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291497PMC

SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells.

Cancer Cell Int 2020 12;20:236. Epub 2020 Jun 12.

Department of Pediatrics, Luoyang Central Hospital Affiliated To Zhengzhou University, No. 288 Zhongzhou Middle Road, Luoyang, 471000 Henan China.

Background: Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma. However, the role of SNHG16 in regulating cisplatin sensitivity in neuroblastoma remains largely unknown.

Methods: The expression of SNHG16, microRNA (miR)-338-3p and polo-like kinase 4 (PLK4) mRNA was measured using quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1186/s12935-020-01291-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291484PMC

Identification of methylation-driven genes related to the prognosis of papillary renal cell carcinoma: a study based on The Cancer Genome Atlas.

Cancer Cell Int 2020 12;20:235. Epub 2020 Jun 12.

Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029 China.

Background: Aberrant DNA methylation patterns are involved in the pathogenesis of papillary renal cell carcinoma (pRCC). This study aimed to investigate the potential of methylation-driven genes as biomarkers in determining the prognosis of pRCC by bioinformatics analysis.

Methods: DNA methylation and transcriptome profiling data were downloaded from The Cancer Genome Atlas database. Read More

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http://dx.doi.org/10.1186/s12935-020-01331-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291558PMC

UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.

Cancer Cell Int 2020 12;20:234. Epub 2020 Jun 12.

Department of Breast Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003 Zhejiang China.

Background: A comprehensive investigation of ubiquitin-conjugating enzyme E2I (UBE2I) in cancer is still insufficiency. In this study, we aimed to analyze its role and mechanism in cancer by combination of bioinformatic analysis and experimental validation.

Methods: The expression profile of UBE2I in human cancers were obtained using GEPIA. Read More

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http://dx.doi.org/10.1186/s12935-020-01311-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291483PMC