1,238 results match your criteria Cancer Cell International [Journal]


Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/β-catenin pathway.

Cancer Cell Int 2019 16;19:102. Epub 2019 Apr 16.

1Department of General Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001 People's Republic of China.

Background: Most colorectal cancer (CRC) patients are diagnosed at an advanced or metastatic stage with poor prognosis. Ubiquitin-specific protease 6 N-terminal-like protein (USP6NL) with high expression in CRC tissues regulates CRC cell proliferation via Wnt/β-catenin pathway. We hypothesized that USP6NL impacts CRC growth and inhibition of USP6NL may be a novel treatment strategy to improve CRC therapy. Read More

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http://dx.doi.org/10.1186/s12935-019-0823-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469084PMC

Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients.

Cancer Cell Int 2019 16;19:101. Epub 2019 Apr 16.

1Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, 213003 Jiangsu China.

Background: It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an important breakthrough in the treatment against ccRCC. HHLA2, a recently reported member of B7 family, is uniquely expressed in humans but not in mice, and it plays an important role in the functional inhibition of CD4 and CD8 T cells. Read More

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http://dx.doi.org/10.1186/s12935-019-0813-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469208PMC

A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis.

Cancer Cell Int 2019 16;19:100. Epub 2019 Apr 16.

6Institute of Radiation Biology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Background: Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized therapy.

Methods: With the aim to identify a novel mRNA signature associated with overall survival, we analysed LUAD patients with LNM extracted from The Cancer Genome Atlas (TCGA). Read More

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http://dx.doi.org/10.1186/s12935-019-0822-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469135PMC

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair.

Cancer Cell Int 2019 15;19:99. Epub 2019 Apr 15.

3Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Tianjin Medical University, Tianjin, 300070 China.

Background: Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deubiquitinase 4 (OTUD4) has been reported involved in DNA damage repair pathways and could be a potential target for chemotherapy therapy. Read More

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http://dx.doi.org/10.1186/s12935-019-0816-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466656PMC

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways.

Cancer Cell Int 2019 15;19:98. Epub 2019 Apr 15.

1Department of Microbiology, Biochemistry and Immunology and Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA 30310 USA.

Background: Currently offered therapeutics to treat colon cancer (CoCa) are toxic when given at maximum tolerated dose to achieve optimal clinical response. Hence, less toxic therapeutic intervention is needed to treat CoCa. In this study, we investigated the effect of a natural agent, Emodin, on CoCa. Read More

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http://dx.doi.org/10.1186/s12935-019-0820-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466701PMC

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway.

Cancer Cell Int 2019 11;19:97. Epub 2019 Apr 11.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, No. 95, Yong'an Road, Xicheng District, Beijing, 100050 People's Republic of China.

Background: 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro.

Methods: SW480 cells were in the present study and treated with 5-FU. Read More

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http://dx.doi.org/10.1186/s12935-019-0812-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460675PMC

Correction to: ZEB1‑AS1 initiates a miRNA‑mediated ceRNA network to facilitate gastric cancer progression.

Cancer Cell Int 2019 11;19:95. Epub 2019 Apr 11.

1Department of Gastroenterological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032 China.

[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. Read More

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http://dx.doi.org/10.1186/s12935-019-0797-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458764PMC

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin.

Cancer Cell Int 2019 11;19:92. Epub 2019 Apr 11.

1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032 China.

Aim Of The Review: In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been studied in vitro, in vivo and clinical studies. This review aims to summarize the multi-target and multi-pathway pharmacological effects of Bufalin and Huachansu in the last decade, with the aim of providing a more comprehensive view and highlighting the recently discovered molecular mechanisms. Read More

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http://dx.doi.org/10.1186/s12935-019-0806-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458819PMC

Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4.

Cancer Cell Int 2019 11;19:94. Epub 2019 Apr 11.

Department of Gastroenterology, Jiangxi Pingxiang People's Hospital, No. 8, Wugongshan Middle Road, Pingxiang, 337000 Jiangxi People's Republic of China.

Background: In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppressors in cancers. Therefore, we investigated the effect of LINC01314 on the development of GC cells in relation to the Wnt/β-catenin signaling pathway. Read More

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http://dx.doi.org/10.1186/s12935-019-0799-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458728PMC

PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells.

Cancer Cell Int 2019 11;19:93. Epub 2019 Apr 11.

1School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004 China.

Background: Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully understood and the function requires to be further elucidated. Read More

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http://dx.doi.org/10.1186/s12935-019-0810-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458718PMC

The role of photodynamic therapy on multidrug resistant breast cancer.

Cancer Cell Int 2019 11;19:91. Epub 2019 Apr 11.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, 2028 South Africa.

Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional DNA repair genes are common features with breast cancer resistance. Chemo-resistance of breast cancer associated with multidrug resistance events utilizes ATP-binding cassette (ABC) efflux transporters to decrease drug intracellular concentration. Read More

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http://dx.doi.org/10.1186/s12935-019-0815-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458738PMC

Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma.

Cancer Cell Int 2019 11;19:90. Epub 2019 Apr 11.

1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network and have attracted growing attention. The present study explored the regulatory mechanisms and functional roles of lncRNAs as ceRNAs in hepatocellular carcinoma (HCC) and their potential impact on HCC patient prognosis.

Methods: In this study, we systematically studied the expression profiles and prognostic value of lncRNA, miRNA, and mRNA from a total of 838 HCC patients from five HCC cohorts (TCGA, GSE54236, GSE76427, GSE64041 and GSE14520). Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0817-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458652PMC
April 2019
1 Read

Systems biology based meth-miRNA-mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression.

Cancer Cell Int 2019 8;19:89. Epub 2019 Apr 8.

Department of Biological Sciences, National University of Medical Sciences (NUMS), Abid Majeed Road, Rawalpindi, Pakistan.

Background: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading to abnormal expression of different genes as important regulators of disease onset and progression in HCC. Here, using systems biology approaches, we aimed to integrate methylation, miRNA profiling and gene expression data into a regulatory methylation-miRNA-mRNA (meth-miRNA-mRNA) network to better understand the onset and progression of the disease. Read More

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http://dx.doi.org/10.1186/s12935-019-0804-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454777PMC

Retraction Note: Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.

Cancer Cell Int 2019 8;19:88. Epub 2019 Apr 8.

1School of Basic Medical Sciences, Zhengzhou University, No.100 Kexue Road, 450001 Zhengzhou, Henan China.

[This retracts the article DOI: 10.1186/s12935-016-0362-x.]. Read More

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http://dx.doi.org/10.1186/s12935-019-0814-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452508PMC
April 2019
1.989 Impact Factor

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression.

Cancer Cell Int 2019 5;19:87. Epub 2019 Apr 5.

16Department of Pharmacy, China Medical University, Taichung, 404 Taiwan.

Background: To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

Methods: We systematically evaluated 79 germline variants in nine circadian pathway genes in a cohort of 458 patients with localized prostate cancer as the discovery phase. We then replicated the significant findings in another cohort of 324 men with more advanced disease. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0811-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451277PMC
April 2019
1 Read

Stimulative role of ST6GALNAC1 in proliferation, migration and invasion of ovarian cancer stem cells via the Akt signaling pathway.

Cancer Cell Int 2019 5;19:86. Epub 2019 Apr 5.

1Department of Obstetrics and Gynecology, The Second Hospital of Anhui Medical University, Hefei, 230601 People's Republic of China.

Background: Ovarian cancer is known as one of the most common cancers in the world among women. ST6GALNAC1 is highly expressed in cancer stem cells (CSCs), which correlates to high tumor-initiating, self-renewal and differentiation abilities. This present study aims to investigate how ST6GALNAC1 affects ovarian cancer stem cells (OCSCs). Read More

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http://dx.doi.org/10.1186/s12935-019-0780-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451308PMC
April 2019
1 Read

Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague-Dawley rats.

Cancer Cell Int 2019 4;19:85. Epub 2019 Apr 4.

1Department of Urology, Institute for Medical Sciences, Chonbuk National University Medical School-Biomedical Research and Institute and Clinical Trial Center for Medical Devices, Chonbuk National University Hospital, Jeonju, 54907 Republic of Korea.

Background: DA-9401 was prepared as a mixture of Chinese medicinal herb extracts from roots of Morinda officinalis How (Rubiaceae), outer scales of L. (Liliceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae). The present study was designed to investigate the possible protective role of DA-9401 in adriamycin (ADR)-induced testicular toxicity associated with oxidative stress, endoplasmic reticulum (ER) stress, and apoptosis. Read More

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http://dx.doi.org/10.1186/s12935-019-0805-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450013PMC
April 2019
3 Reads

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin-proteasome pathway contributes to the reversion of ATRA resistance.

Cancer Cell Int 2019 4;19:84. Epub 2019 Apr 4.

1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.

Background: - is a newly identified fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from the classic - in terms of therapeutic reaction.

Methods: To reveal the functional characteristics and regulating mechanism of the - fusion gene, we established a --transfected HL60 cell model and examined its sensitivity to ATRA by western blot, MTT assay, flow cytometry, and Wright-Giemsa staining. Read More

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http://dx.doi.org/10.1186/s12935-019-0803-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449960PMC
April 2019
1 Read

The assessment of minimal residual disease versus that of somatic mutations for predicting the outcome of acute myeloid leukemia patients.

Cancer Cell Int 2019 4;19:83. Epub 2019 Apr 4.

1Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy.

Background: In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic mutations could represent an additional prognostic value in respect of MRD alone.

Method: At baseline, 98 patients were tested for , , and for expression; 31 for , , , , -, , -, , and . Read More

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http://dx.doi.org/10.1186/s12935-019-0807-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449954PMC
April 2019
1 Read

Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcoma.

Cancer Cell Int 2019 3;19:82. Epub 2019 Apr 3.

Department of Orthopedics, Shangqiu First People's Hospital, No.292, Kaixuan Road, Shangqiu, 476100 China.

Background: lncRNAs have been proved to play crucial parts in various human cytopathology and cell physiology, including tumorigenesis. Down-regulated lncRNAs SNHG6 have shown great cell proliferation inhibitory effects in cancer development. Here we investigated how SNHG6 effected human osteosarcoma (OS) development and progression. Read More

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http://dx.doi.org/10.1186/s12935-019-0794-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448242PMC

A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer.

Cancer Cell Int 2019 3;19:81. Epub 2019 Apr 3.

4Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KY 40202 USA.

Background: Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used in clinic for gastric cancer treatment but with toxic side effects and develops resistance. Anti-tumor properties of copper and its coordinated compounds have been explored intensively in recent years. Read More

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http://dx.doi.org/10.1186/s12935-019-0801-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448317PMC
April 2019
1 Read
1.989 Impact Factor

Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis.

Cancer Cell Int 2019 2;19:80. Epub 2019 Apr 2.

1Laboratorio de Genómica Funcional, Unidad de Biomedicina, FES-IZTACALA, UNAM, Tlalnepantla, Mexico.

Background: Invasion and metastasis are determinant events in the prognosis of Colorectal cancer (CRC), a common neoplasm worldwide. An important factor for metastasis is the acquired capacity of the cell to proliferate and invade adjacent tissues. In this paper, we explored the role of micro-RNA-26a in the regulation of proliferation and migration in CRC-derived cells through the negative regulation of PTEN, a key negative regulator of the AKT pathway. Read More

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http://dx.doi.org/10.1186/s12935-019-0802-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444875PMC

Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis.

Cancer Cell Int 2019 2;19:79. Epub 2019 Apr 2.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 China.

Background: The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies.

Methods: Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Read More

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http://dx.doi.org/10.1186/s12935-019-0788-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444518PMC
April 2019
3 Reads

Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy.

Cancer Cell Int 2019 29;19:78. Epub 2019 Mar 29.

Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Pudong New District, Shanghai, 200127 People's Republic of China.

Background: Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in various kinds of cancers. Here, we aimed to determine whether the expression of the ZEB1 protein is related to the response of patients to neoadjuvant therapy as well as their survival outcome.

Methods: Immunohistochemistry (IHC) was performed on paraffin-embedded tumor samples from core needle biopsy before neoadjuvant therapy (NAT). Read More

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http://dx.doi.org/10.1186/s12935-019-0793-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441148PMC
March 2019
1.989 Impact Factor

Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells.

Cancer Cell Int 2019 29;19:77. Epub 2019 Mar 29.

1Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

Background: The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC).

Methods: Cortactin and phosphorylated cortactin (Y421) were investigated immunohistochemically in 66 PDAC tumor specimens. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0798-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441202PMC
March 2019
2 Reads

GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies.

Cancer Cell Int 2019 29;19:76. Epub 2019 Mar 29.

Department of Interventional Vascular Surgery, The Affiliated Bao ji Central Hospital of Xi'an Jiaotong University College of Medicine, Bao ji, 721008 Shaan xi China.

Background: It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that glutathione -transferase (GST) genotypes are associated with HCC, the conclusions are inconsistent. Read More

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http://dx.doi.org/10.1186/s12935-019-0792-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441207PMC
March 2019
1 Read

TMED3 promotes cell proliferation and motility in breast cancer and is negatively modulated by miR-188-3p.

Cancer Cell Int 2019 29;19:75. Epub 2019 Mar 29.

1Department of Breast Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Number 218, Jixi Road, Hefei, 230022 Anhui People's Republic of China.

Background: The role of TMED3 involved in cancers has been seldom described, let alone in breast cancer. To explore the clinicopathological significance of TMED3 expression and the biological roles involved in breast cancer cells, we undertook the study.

Methods: Immunohistochemistry was performed to observe the pattern of TMED3 expression in breast cancer tissues, totaling 224 cases; followed by detailed statistical analysis between TMED3 expression versus clinicopathological information available. Read More

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http://dx.doi.org/10.1186/s12935-019-0791-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441222PMC
March 2019
1 Read

The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma.

Cancer Cell Int 2019 29;19:74. Epub 2019 Mar 29.

1School of Medicine, Jiangsu University, Zhenjiang, Jiangsu China.

Background: Gastric cardia adenocarcinoma (GCA) is an aggressive subtype of gastric cancer with a high metastatic rate. However, the metastatic biomarker of GCA has not been established.

Methods: To search for the biomarker for GCA metastasis, we here examined expression of the Hippo signaling effector WWTR1 (WW domain containing transcription regulator 1, commonly listed as TAZ) in tumor tissue samples from 214 GCA cases using the tissue microarray assay (TMA), and statistically analyzed association of the WWTR1 expression with metastasis-related pathological outcomes and cumulative survival of the GCA patients. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0796-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439973PMC
March 2019
2 Reads

An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia.

Cancer Cell Int 2019 27;19:73. Epub 2019 Mar 27.

1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd. MDC7, Tampa, USA.

Background: Pediatric cancer survival rates overall have been improving, but neuroblastoma (NBL) and acute lymphoblastic leukemia (ALL), two of the more prevalent pediatric cancers, remain particularly challenging. One issue not yet fully addressed is distinctions attributable to age of diagnosis.

Methods: In this report, we verified a survival difference based on diagnostic age for both pediatric NBL and pediatric ALL datasets, with younger patients surviving longer for both diseases. Read More

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http://dx.doi.org/10.1186/s12935-019-0790-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438000PMC
March 2019
1 Read

LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer.

Cancer Cell Int 2019 27;19:72. Epub 2019 Mar 27.

Department of Gastrointestinal, The Affiliated Hospital of Zunyi Medical College, Huichuan Area, Dalian Road 149, Zunyi, 563000 Guizhou Province China.

Background: Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal cancer (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon cancer remains largely unknown. In this study, we hypothesized that BCAR4 could regulate colon cancer stem/initiating cells (CSC) function and further facilitates the colon cancer progression. Read More

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http://dx.doi.org/10.1186/s12935-019-0784-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438025PMC
March 2019
1 Read

Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma.

Cancer Cell Int 2019 25;19:71. Epub 2019 Mar 25.

1Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.

Background: Oxaliplatin-based chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Recent studies suggested that therapeutic resistance of tumors was affected by tumor microenvironment (TME). As a major component of TME, the role of tumor-associated macrophages (TAMs) on drug resistance in HCC is largely unknown. Read More

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http://dx.doi.org/10.1186/s12935-019-0771-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434873PMC
March 2019
1 Read

Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: a meta-analysis.

Cancer Cell Int 2019 25;19:70. Epub 2019 Mar 25.

2State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620 China.

Background: Pretreatment inflammatory factors, including neutrophil, lymphocyte, platelet and monocyte counts as well as the ratios between them such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) have been suggested as potential prognostic predictors for patients with prostate cancer (PCa). However, the prognostic effects remain controversial. Therefore, the goal of this study was evaluate the prognostic values of these markers for PCa patients using a meta-analysis. Read More

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http://dx.doi.org/10.1186/s12935-019-0785-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434630PMC

Palmitate acid promotes gastric cancer metastasis via FABP5/SP1/UCA1 pathway.

Cancer Cell Int 2019 22;19:69. Epub 2019 Mar 22.

Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China.

Background: Gastric cancer (GC) has a clear predilection for metastasis toward omentum which is primarily composed of adipose tissue, combine with our previous research that long non-coding RNA Urothelial cancer associated 1 (UCA1) could promote the peritoneal metastasis of GC, we put forward the hypothesis that fatty acids (FAs) might contribute to these phenomena and a connection between FAs and UCA1 might exist.

Methods: TCGA database was applied to investigate the expression levels of UCA1 in GC tissues and normal gastric tissues and its correlation with GC patients' survival. Transfection of siRNA was utilized to knockdown cellular levels of FA-binding protein 5 (FABP5), SP1, UCA1. Read More

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http://dx.doi.org/10.1186/s12935-019-0787-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431020PMC
March 2019
2 Reads

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells.

Cancer Cell Int 2019 21;19:68. Epub 2019 Mar 21.

Department of Respiratory Medicine, The Fifth People's Hospital of Wuxi City, Wuxi, 214016 China.

Background: Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we aimed to investigate whether lycopene could promote the effect of anti-PD-1 treatment on lung cancer.

Methods: Tumor formation assay was conducted. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0789-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429703PMC
March 2019
3 Reads

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy.

Cancer Cell Int 2019 21;19:67. Epub 2019 Mar 21.

1Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: Low molecular weight protein tyrosine phosphatase (LMW-PTP) is overexpressed in different cancer types and its expression is related to more aggressive disease, reduced survival rate and drug resistance. Morin is a natural polyphenol which negatively modulates, among others, the activity of LMW-PTP, leading to the potentiation of the effects of different antitumoral drugs, representing a potential beneficial treatment against cancer.

Methods: LMW-PTP levels were measured by immunoblot analysis both in CLL cells from patients and in chronic lymphocytic leukemia (CLL)-derived Mec-1 cells. Read More

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http://dx.doi.org/10.1186/s12935-019-0786-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429822PMC
March 2019
2 Reads

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway.

Cancer Cell Int 2019 20;19:66. Epub 2019 Mar 20.

2Department of Gynaecology and Obstetrics, Changzhou Maternal and Child Health Care Hospital Affiliated Nanjing Medical University, Changzhou, China.

Background: The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-MSCs inducing cell proliferation and glycolysis needs further research.

Methods: miRNA array was used to analyze the significant miRNAs. Read More

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http://dx.doi.org/10.1186/s12935-019-0751-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427852PMC
March 2019
1.989 Impact Factor

Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma.

Cancer Cell Int 2019 20;19:64. Epub 2019 Mar 20.

1Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515 China.

Background: Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous membrane. Read More

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http://dx.doi.org/10.1186/s12935-019-0772-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425698PMC
March 2019
2 Reads

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.

Cancer Cell Int 2019 20;19:65. Epub 2019 Mar 20.

1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.

Background: Xinjiang is one of the areas with the highest incidence of cervical cancer in China. Genetic variation in Human papillomavirus type 16 (HPV16) may increase the ability of the virus to mediate carcinogenesis and immune escape, which are risk factors for the progression of cervical cancer. We investigated polymorphism in HPV16 and the distribution of its sub-lineages in the region by analyzing the , and () gene sequences from women with HPV16-positive cervical samples in Xinjiang. Read More

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http://dx.doi.org/10.1186/s12935-019-0774-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425590PMC
March 2019
3 Reads

High long non-coding RNA NORAD expression predicts poor prognosis and promotes breast cancer progression by regulating TGF-β pathway.

Cancer Cell Int 2019 20;19:63. Epub 2019 Mar 20.

1Department of General Surgery, The Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan, 442000 Hubei China.

Background: To investigate the expression and significance of long noncoding RNA NORAD (lncRNA-NORAD) in breast cancer.

Methods: Q-PCR was adopted to detect the mRNA expression of lncRNA-NORAD in breast cancer and adjacent tissues, survival analysis to compare the low-expression groups with the Kaplan-Meier method. Knockout of lncRNA-NORAD was adopted to observe the effects on the cell proliferation, migration and invasion of breast cancer in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s12935-019-0781-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425604PMC
March 2019
2 Reads

The prognostic value of serum amyloid A in solid tumors: a meta-analysis.

Cancer Cell Int 2019 20;19:62. Epub 2019 Mar 20.

4Clinical Department of Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080 Guangdong China.

Background: Previous studies have demonstrated that serum amyloid A (SAA) levels are correlated with the clinical outcomes of solid tumors. However, the available data have not been systematically evaluated. The objective of the present meta-analysis was to explore the prognostic value of SAA levels in solid tumors. Read More

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http://dx.doi.org/10.1186/s12935-019-0783-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425599PMC
March 2019
1 Read

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway.

Cancer Cell Int 2019 18;19:61. Epub 2019 Mar 18.

1Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001 Jiangsu People's Republic of China.

Background: Mitogen-activated protein kinase phosphatases-4 (MKP-4) is reported to exert a prognostic merit in hepatocarcinogenesis. However, the underlying molecular mechanisms have not been clearly defined.

Methods: Immunoprecipitation-mass spectrometry (IP-MS) approach was used to identify interactive proteins with MKP-4. Read More

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http://dx.doi.org/10.1186/s12935-019-0776-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423746PMC
March 2019
1 Read

LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK-Mfn2 signaling pathway.

Cancer Cell Int 2019 18;19:60. Epub 2019 Mar 18.

1Department of Hepatopancreatobiliary Medicine, The Second Hospital of Jilin University, Changchun, 130000 China.

Background: Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib is a first-line drug for the treatment of HCC. However, the clinical benefit of sorafenib is often impaired by drug resistance. Accordingly, the present study was conducted to investigate the molecular mechanisms involving sorafenib resistance, with a focus on large tumor suppressor 2 (LATS2) and mitophagy. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0778-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423758PMC
March 2019
5 Reads

Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy.

Cancer Cell Int 2019 15;19:59. Epub 2019 Mar 15.

Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, 325 Jing Wu Rd, Jinan, 250021 Shandong People's Republic of China.

Immune thrombocytopenic purpura (ITP) is a multifactorial autoimmune disease characterized by both increased platelet destruction and/or reduced platelet production. Even though they are detected in ≤ 50% of ITP patients, auto-antibodies play a pivotal role in the pathogenesis of ITP. Recent experimental and clinical observations have revealed abnormal autophagy in ITP patients. Read More

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http://dx.doi.org/10.1186/s12935-019-0779-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419848PMC
March 2019
1 Read

Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis.

Cancer Cell Int 2019 14;19:58. Epub 2019 Mar 14.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, No.2 Jinba Road, Zhengzhou, 450014 China.

Background: Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis.

Methods: HeLa cells were incubated with TNFα and then cell death was determined via MTT assay, TUNEL staining, caspase ELISA assay and western blotting. Read More

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http://dx.doi.org/10.1186/s12935-019-0777-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419493PMC
March 2019
1 Read

TRIM52 promotes colorectal cancer cell proliferation through the STAT3 signaling.

Cancer Cell Int 2019 14;19:57. Epub 2019 Mar 14.

Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People's Hospital, No. 8 Caobao Road, Xuhui District, Shanghai, 200232 China.

Background: The tripartite motif (TRIM) family proteins are implicated in the pathogenesis of various human malignancies. The up-regulation and oncogenic roles of TRIM52 have been reported in hepatocellular carcinoma. In the current study, we aimed to examine its expression and possible function in colorectal cancer (CRC). Read More

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http://dx.doi.org/10.1186/s12935-019-0775-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419475PMC

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia.

Cancer Cell Int 2019 13;19:56. Epub 2019 Mar 13.

1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.

Background: T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors with poor outcomes. WP1130 has shown potent activity against a variety of cancer but whether WP1130 has anti-T-ALL activity is not clear. USP24, one target of WP1130, is one of the largest deubiquitinases and its detailed mechanism is poorly understood. Read More

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http://dx.doi.org/10.1186/s12935-019-0773-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415346PMC
March 2019
1 Read

A 3'-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis.

Cancer Cell Int 2019 11;19:55. Epub 2019 Mar 11.

1Department of Physiology, Nanjing Medical University, 101 Longmian Road, Nanjing, 211166 China.

Background: Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a member of microfilament-related formins and mediates cell motility in breast cancer (BrCa). However, the genetic mutation status of mRNA and its correlation with pathological characteristics are still unclearly. Methods: A patient cohort and BrCa cells were recruited to demonstrate the role of functional SNP in microRNA-208a-5p binding site of 3'-UTR and underlying mechanism in BrCa metastasis. Read More

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http://dx.doi.org/10.1186/s12935-019-0747-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417246PMC
March 2019
1 Read

Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase.

Cancer Cell Int 2019 8;19:54. Epub 2019 Mar 8.

1Department of Systems Biology, Biochemistry and Molecular Biology Unit, School of Medicine and Health Sciences, Alcala University, Alcalá de Henares, Ctra A-2 Km 32., 28871 Madrid, Spain.

Background: Current chemotherapy for castration-resistant prostate cancer is established on taxane-based compounds like docetaxel. However, eventually, the development of toxic side effects and resistance limits the therapeutic benefit being the major concern in the treatment of prostate cancer. Combination therapies in many cases, enhance drug efficacy and delay the appearance of undesired effects, representing an important option for the treatment of castration-resistant prostate cancer. Read More

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http://dx.doi.org/10.1186/s12935-019-0769-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408806PMC

mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response.

Cancer Cell Int 2019 7;19:53. Epub 2019 Mar 7.

1Northern Institute for Cancer Research, School of Medicine, Newcastle University, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH UK.

Background: Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents.

Methods: In the current study, wild-type cell lines with druggable MAPK pathway mutations [ (WM35) or (SJSA-1)] were compared with their mutant sublines (WM35-R, SN40R2) derived by selection for resistance to MDM2/p53 binding antagonists. Read More

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http://dx.doi.org/10.1186/s12935-019-0768-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407233PMC
March 2019
1 Read

Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas.

Cancer Cell Int 2019 6;19:52. Epub 2019 Mar 6.

1Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao, 266003 China.

Background: Aberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by integrative bioinformatics analysis.

Methods: Data of DNA methylation and transcriptome profiling were downloaded from TCGA database. Read More

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http://dx.doi.org/10.1186/s12935-019-0770-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404309PMC