1,164 results match your criteria Cancer Cell International [Journal]


ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression.

Cancer Cell Int 2019 6;19:27. Epub 2019 Feb 6.

1Department of Gastroenterological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032 China.

Background: Currently, cancer-related competing endogenous RNA (ceRNA) networks are attracting significant interest. As long noncoding RNA ZEB1-AS1 has been reported to function as an oncogene due to sponging microRNAs (miRNAs) in several cancers, we hypothesized that it could interact with specific miRNAs to form regulatory networks and facilitate the growth of gastric cancer (GC).

Methods: MiRNAs interacting with ZEB1-AS1 were screened for and selected by bioinformatics analysis. Read More

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http://dx.doi.org/10.1186/s12935-019-0742-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364449PMC
February 2019

CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death.

Cancer Cell Int 2019 4;19:26. Epub 2019 Feb 4.

2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, CB #7260, Chapel Hill, NC 27599 USA.

Background: Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and integrin-binding protein 1 (CIB1) induces cell death selectively in TNBC cells, while sparing normal cells. Therefore, we asked whether CIB1 depletion further enhances tumor-specific killing when combined with either the commonly used chemotherapeutic, docetaxel, or the cell death-inducing ligand, TRAIL. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0740-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360800PMC
February 2019
6 Reads

hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway.

Cancer Cell Int 2019 1;19:25. Epub 2019 Feb 1.

4Department of Orthopedic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100 Henan China.

Background: Increasing studies indicated that circRNAs play critical roles in tumor progression. However, the roles and underlying mechanisms of circRNAs in gastric cancer (GC) remain largely unclear.

Methods: Microarray assay was used to screen the abnormally expressed circRNAs in GC. Read More

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http://dx.doi.org/10.1186/s12935-019-0737-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359821PMC
February 2019
1 Read

SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia.

Cancer Cell Int 2019 31;19:24. Epub 2019 Jan 31.

1State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032 China.

Background: Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux and subsequent chronic inflammation are key causal factors of IM. Previous studies indicated that SOX2, the key transcription factor in gastric differentiation, was downregulated during IM development while CDX2, the pivotal intestine-specific transcription factor was upregulated significantly. Read More

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http://dx.doi.org/10.1186/s12935-019-0739-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357452PMC
January 2019
1.989 Impact Factor

Expression signatures and roles of microRNAs in inflammatory breast cancer.

Cancer Cell Int 2019 31;19:23. Epub 2019 Jan 31.

1Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 China.

Inflammatory breast cancer (IBC) is an infrequent but aggressive manifestation of breast cancer, which accounts for 2-4% of all breast cancer cases but responsible for 7-10% of breast cancer-related deaths, and with a 20-30% 10-year overall survival compared with 80% for patients with non-IBC with an unordinary phenotype, whose molecular mechanisms are still largely unknown to date. Discovering and identifying novel bio-markers responsible for diagnosis and therapeutic targets is a pressing need. MicroRNAs are a class of small non-coding RNAs that are capable to post-transcriptionally regulate gene expression of genes by targeting mRNAs, exerting vital and tremendous affects in numerous malignancy-related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Read More

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http://dx.doi.org/10.1186/s12935-018-0709-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357482PMC
January 2019
2 Reads

Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis.

Cancer Cell Int 2019 29;19:22. Epub 2019 Jan 29.

The 2nd Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 34 Huangtang Road, Guangdong, 514031 China.

Background: A series of studies has investigated the prognostic role and clinical significance of programmed death ligand 1 (PD-L1) in hepatocellular carcinoma (HCC). However, the results were inconsistent. We aimed to clarify the prognostic role of PD-L1 and relationship between PD-L1 expression and several important clinicopathological features. Read More

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http://dx.doi.org/10.1186/s12935-019-0738-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352338PMC
January 2019
1 Read

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo.

Cancer Cell Int 2019 29;19:21. Epub 2019 Jan 29.

Institute of Traditional Chinese Medicine Oncology, Shanghai Institute of Traditional Chinese Medicine, Shanghai, 200032 People's Republic of China.

Background: Circulating tumor cells (CTCs) have been described as a population of cells that may seed metastasis, which is a reliable target for the prevention of metastases in lung cancer patients at the early stage. The culturing of CTCs in vitro can be used to study the mechanism of lung cancer metastasis and to screen antimetastasis drugs. This study aims to establish CTC cell line in vitro and explore the potential mechanism of its metastasis. Read More

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http://dx.doi.org/10.1186/s12935-019-0735-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352330PMC
January 2019
1 Read

Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN.

Cancer Cell Int 2019 22;19:20. Epub 2019 Jan 22.

1Department of Orthopaedic Surgery, the PLA General Hospital, Beijing, 100000 China.

Background: Increasingly evidences suggest that long noncoding RNAs (lncRNAs) play important roles in various cancers. LncRNA PXN-AS1-L is recently revealed to act as on oncogene in liver cancer. However, the expression, functions, and mechanisms of action of PXN-AS-L in non-small cell lung cancer (NSCLC) remain unclear. Read More

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http://dx.doi.org/10.1186/s12935-019-0734-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341638PMC
January 2019

Potential new biomarkers for endometrial cancer.

Cancer Cell Int 2019 21;19:19. Epub 2019 Jan 21.

1Department of Microbiology and Molecular Biology, Brigham Young University, 3142 LSB, Provo, UT 84602 USA.

Background: Incidence of endometrial cancer are rising both in the United States and worldwide. As endometrial cancer becomes more prominent, the need to develop and characterize biomarkers for early stage diagnosis and the treatment of endometrial cancer has become an important priority. Several biomarkers currently used to diagnose endometrial cancer are directly related to obesity. Read More

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http://dx.doi.org/10.1186/s12935-019-0731-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341571PMC
January 2019

Long non-coding RNA CASC2 upregulates PTEN to suppress pancreatic carcinoma cell metastasis by downregulating miR-21.

Cancer Cell Int 2019 16;19:18. Epub 2019 Jan 16.

Department of Hepatopancreatobiliary Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4 South Renmin Road, Chengdu, 610041 China.

Background: The mechanism of pancreatic cancer metastasis remains poorly understood. Recently, lncRNA CASC2 has been demonstrated to be a tumor suppressor in various types of cancer. This study aimed to explore the mechanism of CASC2 in the regulation of pancreatic cancer metastasis. Read More

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http://dx.doi.org/10.1186/s12935-019-0728-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335738PMC
January 2019

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Cancer Cell Int 2019 16;19:17. Epub 2019 Jan 16.

Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Huinan Town, Pudong, Shanghai, 201399 China.

Background: In our previous study, we demonstrated that Sirtuin 6 (SIRT6) is upregulated and associated with papillary thyroid cancer (PTC) progression (Qu et al. in Int J Oncol 50(5):1683-92, 2017). This study examined whether SIRT6 promotes epithelial-mesenchymal transition (EMT) of papillary thyroid cancer through hypoxia inducible factor-1α (HIF-1α). Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0730-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335740PMC
January 2019
3 Reads

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer.

Cancer Cell Int 2019 14;19:16. Epub 2019 Jan 14.

1Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment in clinically relevant in vitro tumor models is essential. Five HNSCC-derived cell lines were used to assess the effect of 3D culturing compared to 2D monolayers in terms of cell proliferation, response to anti-cancer therapy as well as expression of EMT and CSC genes. Read More

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http://dx.doi.org/10.1186/s12935-019-0733-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332598PMC
January 2019
1 Read

MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1.

Cancer Cell Int 2019 14;19:15. Epub 2019 Jan 14.

Department of infectious disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan People's Republic of China.

Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0729-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332595PMC
January 2019
4 Reads

Correction to: Next-generation sequencing-based genetic landscape and its clinical implications for Chinese acute myeloid leukemia patients.

Cancer Cell Int 2019 14;19:14. Epub 2019 Jan 14.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Dongcheng District, Beijing, 100730 People's Republic of China.

[This corrects the article DOI: 10.1186/s12935-018-0716-7.]. Read More

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http://dx.doi.org/10.1186/s12935-019-0736-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330738PMC
January 2019
3 Reads

Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway.

Cancer Cell Int 2019 11;19:13. Epub 2019 Jan 11.

1Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, 1 Yi Xue Yuan Road, Chongqing, 400016 China.

Background: Rosiglitazone metformin adduct (RZM) is a novel compound, synthesized from rosiglitazone (Ros) and metformin (Met) combined at a molar mass ratio of 1:1. Met and Ros are widely used together for treating type 2 diabetes to improve drug effectiveness and reduce adverse drug reactions. Recent studies reported that both Met and Ros may possess antineoplastic properties in several cancers, including hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1186/s12935-019-0732-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330460PMC
January 2019
1 Read

CRISPR-Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics.

Cancer Cell Int 2019 8;19:12. Epub 2019 Jan 8.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY USA.

Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology essential for understanding gene function. CRISPR/Cas9 is a targeted genome-editing platform derived from bacterial adaptive immune system and has been repurposed into a genome-editing tool. The RNA-guided DNA endonuclease, Cas9 can be easily programmed to target new sites by altering its guide RNA sequence, making this technology easier, more efficient, scalable and an indispensable tool in biological research. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0726-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325665PMC
January 2019
9 Reads
1.989 Impact Factor

Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women.

Cancer Cell Int 2019 8;19:11. Epub 2019 Jan 8.

2Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.

Background: Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case-control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women. Read More

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http://dx.doi.org/10.1186/s12935-019-0727-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325673PMC
January 2019
3 Reads

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target.

Cancer Cell Int 2019 8;19:10. Epub 2019 Jan 8.

1Obstetrics and Gynecology, University of British Columbia, Vancouver, BC Canada.

Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (MEKi) are being tested in clinical trials. LGSC respond to MEKi only in a subgroup of patients, so predictive biomarkers and better therapies will be needed. Read More

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http://dx.doi.org/10.1186/s12935-019-0725-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325847PMC
January 2019
2 Reads

Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.

Cancer Cell Int 2019 8;19. Epub 2019 Jan 8.

1Medical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, 115 Jie Fang Road, Jinan, Shandong 250013 People's Republic of China.

Background: T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL.

Methods: In this study, we collected the bone marrow samples from 17 T-ALL patients and 38 healthy participants to find differences in CD59 expression patterns. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0714-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325688PMC
January 2019
4 Reads

Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis.

Cancer Cell Int 2019 8;19. Epub 2019 Jan 8.

2Department of Obstetrics and Gynaecology, The First People's Hospital of Foshan, Foshan, China.

Background: Cervical carcinoma is a major gynecological cancer and causes cancer-related deaths in worldwide, the latent pathogenesis and progress of cervical cancer is still under research. ClC-3 may be an important promoter for aggressive metastasis of malignant tumors. In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0721-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325671PMC
January 2019
4 Reads

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species.

Cancer Cell Int 2019 5;19. Epub 2019 Jan 5.

1Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Rd, Shanghai, 200233 China.

Background: Gambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic cancer remained unclear.

Methods: Cell viability and apoptosis of pancreatic cancer cell lines were determined using (4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan and flow cytometry. Read More

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http://dx.doi.org/10.1186/s12935-018-0705-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321668PMC
January 2019
1 Read

Identification of a 6-gene signature predicting prognosis for colorectal cancer.

Cancer Cell Int 2019 5;19. Epub 2019 Jan 5.

3Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475001 Henan Province China.

Background: An accurate and robust gene signature is of the utmost importance in assisting oncologists to make a more accurate evaluation in clinical practice. In our study, we extracted key mRNAs significantly related to colorectal cancer (CRC) prognosis and we constructed an expression-based gene signature to predict CRC patients' survival.

Methods: mRNA expression profiles and clinicopathological data of colon adenocarcinoma (COAD) cases and rectum adenocarcinoma (READ) were collected from The Cancer Genome Atlas database to investigate gene expression alteration associated to the prognosis of CRC. Read More

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http://dx.doi.org/10.1186/s12935-018-0724-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321660PMC
January 2019
2 Reads

Relationship between the upregulation of Notch1 signaling and the clinical characteristics of patients with papillary thyroid carcinoma in East Asia: a systematic review and meta-analysis.

Cancer Cell Int 2019 3;19. Epub 2019 Jan 3.

1Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, No. 661 Second Huanghe Road, Binzhou, 256603 People's Republic of China.

Background: Many studies have aimed to clarify the relationship between Notch1 signaling and papillary thyroid carcinoma (PTC), but the results have been inconsistent to date. In the present study, a systematic review and meta-analysis were performed to analyze the relationship between Notch1 signaling and the clinical characteristics of PTC.

Methods: Literature databases, including PubMed (Medline), Embase and China National Knowledge Infrastructure, were searched for relevant studies from inception to April 2018. Read More

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http://dx.doi.org/10.1186/s12935-018-0723-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317185PMC
January 2019
2 Reads

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response.

Cancer Cell Int 2019 3;19. Epub 2019 Jan 3.

3Key Laboratory of Protein Modification and Tumor, Hubei Polytechnic University School of Medicine, Huangshi, Hubei 435003 People's Republic of China.

Background: The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventing FBXW7-dependent hypoxia-inducible transcription factor-1α (HIF-1α) degradation during hypoxia. However, it remains unclear how USP28 activation and HIF-1α signaling are coordinated in response to hypoxia. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0722-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317191PMC
January 2019
5 Reads

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation.

Cancer Cell Int 2019 3;19. Epub 2019 Jan 3.

3Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang China.

Background: Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated.

Methods: We generated lentiviral constructs to overexpress and silence HOXB8 in CRC cell lines, and examined their biological functions through MTT, wound healing, colony and transwell, expression of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) related factors through western-blot.

Results: HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo. Read More

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http://dx.doi.org/10.1186/s12935-018-0717-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317211PMC
January 2019
4 Reads

T cell receptor-engineered T cells for leukemia immunotherapy.

Cancer Cell Int 2019 3;19. Epub 2019 Jan 3.

1Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, 601 Huang Pu Da Dao Xi, Guangzhou, 510632 People's Republic of China.

At present, refractory and relapse are major issues for leukemia therapy and a major cause of allogeneic hematopoietic stem cell transplant failure. Over the last decade, many studies have demonstrated that adoptive cancer antigen-specific T cell therapy is an effective option for leukemia therapy. Recently, T cell immunotherapy studies have mainly focused on chimeric antigen receptor- and T cell receptor-engineered T cells. Read More

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http://dx.doi.org/10.1186/s12935-018-0720-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317187PMC
January 2019
2 Reads

Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization.

Cancer Cell Int 2019 3;19. Epub 2019 Jan 3.

1Department of Physiology, University of Pretoria, Pretoria, 0084 South Africa.

Background: The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interphase cells, microtubules play an important role in the delivery of proteins to subcellular locations including the focal adhesions. In fact, focal adhesion dynamics and cell migration are in part regulated by microtubules. Read More

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http://dx.doi.org/10.1186/s12935-018-0719-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317210PMC
January 2019
8 Reads

An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma.

Cancer Cell Int 2018 29;18:219. Epub 2018 Dec 29.

5Department of Applied Chemistry, and Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, 54561 Taiwan, ROC.

Background: ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Recent few studies show that ESPN regulates metastasis and cell proliferation in melanoma. However, the significance of ESPN in other cancers such as esophageal squamous cell carcinoma (ESCC) remains largely unknown. Read More

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http://dx.doi.org/10.1186/s12935-018-0713-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310995PMC
December 2018
1 Read

Analysis of PD-1 related immune transcriptional profile in different cancer types.

Cancer Cell Int 2018 27;18:218. Epub 2018 Dec 27.

1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Rd, Wuhan, 430022 People's Republic of China.

Background: Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0712-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307327PMC
December 2018
6 Reads
1.989 Impact Factor

Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation.

Cancer Cell Int 2018 22;18:213. Epub 2018 Dec 22.

1Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong University, 6 Haierxiang North Road, Nantong, 226001 Jiangsu People's Republic of China.

Background: Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to be significantly inhibited in NSCLC. Our research aimed to investigate the molecular mechanisms, clinical significance and epigenetic alteration of SPOP in NSCLC. Read More

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http://dx.doi.org/10.1186/s12935-018-0711-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304003PMC
December 2018
2 Reads

Immunohistochemical investigation of prognostic biomarkers in resected colorectal liver metastases: a systematic review and meta-analysis.

Cancer Cell Int 2018 27;18:217. Epub 2018 Dec 27.

Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 85 Lund, Sweden.

Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Read More

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http://dx.doi.org/10.1186/s12935-018-0715-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307223PMC
December 2018
1 Read

Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231).

Cancer Cell Int 2018 22;18:216. Epub 2018 Dec 22.

Department of Anesthesiology, Pain Mechanisms Lab, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009 USA.

Background: Metastatic cancer to bone is well-known to produce extreme pain. It has been suggested that the magnitude of this perceived pain is associated with disease progression and poor prognosis. These data suggest a potential cross-talk between cancer cells and nociceptors that contribute not only to pain, but also to cancer aggressiveness although the underlying mechanisms are yet to be stablished. Read More

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http://dx.doi.org/10.1186/s12935-018-0707-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303888PMC
December 2018
2 Reads

Next-generation sequencing-based genetic landscape and its clinical implications for Chinese acute myeloid leukemia patients.

Cancer Cell Int 2018 22;18:215. Epub 2018 Dec 22.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Dongcheng District, Beijing, 100730 People's Republic of China.

Background: Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML patients who are more likely to respond to standard cytarabine and daunorubicin induction chemotherapy. Read More

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http://dx.doi.org/10.1186/s12935-018-0716-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303841PMC
December 2018
3 Reads

Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression.

Cancer Cell Int 2018 22;18:214. Epub 2018 Dec 22.

1Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310022 China.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism underlying PDAC progression remains far from clear. Read More

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http://dx.doi.org/10.1186/s12935-018-0718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303882PMC
December 2018
2 Reads
1.989 Impact Factor

Prognostic significance of CXCR7 in cancer patients: a meta-analysis.

Cancer Cell Int 2018 19;18:212. Epub 2018 Dec 19.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as a tumor prognosis marker has not been systematically assessed. The current meta-analysis was performed to obtain an accurate evaluation of the relationship between CXCR7 level and the prognosis of cancer patients. Read More

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http://dx.doi.org/10.1186/s12935-018-0702-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300004PMC
December 2018
1 Read

Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells.

Cancer Cell Int 2018 19;18:211. Epub 2018 Dec 19.

11st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085 Hungary.

Background: Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatments related to their metabolic rewiring and profound heterogeneity in tissue environment. Read More

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http://dx.doi.org/10.1186/s12935-018-0710-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300020PMC
December 2018
2 Reads

miRNA-133b targets FGFR1 and presents multiple tumor suppressor activities in osteosarcoma.

Cancer Cell Int 2018 18;18:210. Epub 2018 Dec 18.

Department of Orthopedics, Guizhou Provincial People's Hospital, No. 83, East Zhongshan Road, Guiyang, 550002 Guizhou People's Republic of China.

Background: Osteosarcoma (OS) is the most common bone malignancy prevalent in children and young adults. MicroRNA-133b (miR-133b), through directly targeting the fibroblast growth factor receptor 1 (FGFR1), is increasingly recognized as a tumor suppressor in different types of cancers. However, little is known on the biological and functional significance of miR-133b/FGFR1 regulation in osteosarcoma. Read More

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http://dx.doi.org/10.1186/s12935-018-0696-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299514PMC
December 2018
2 Reads

Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein.

Cancer Cell Int 2018 18;18:209. Epub 2018 Dec 18.

1Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632 China.

Background: It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein, a key effector of Hippo signaling, functions as a transcription coactivator, plays oncogenic and tumor suppressor roles under different conditions. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0706-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299615PMC
December 2018
11 Reads
1.989 Impact Factor

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3.

Cancer Cell Int 2018 17;18:208. Epub 2018 Dec 17.

1Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No.1 East Jianshe Road, Erqi District, Zhengzhou, 450052 Henan China.

Background: TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism are still unclear.

Methods: Combining bioinformatics with previous studies, the correlation between TRIP13 and HCC was predicted. Read More

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http://dx.doi.org/10.1186/s12935-018-0704-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296061PMC
December 2018
3 Reads

Pre-treatment prognostic nutritional index may serve as a potential biomarker in urinary cancers: a systematic review and meta-analysis.

Cancer Cell Int 2018 17;18:207. Epub 2018 Dec 17.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210009 China.

Background: To investigate the potential prognostic role of pre-treatment prognostic nutritional index (PNI) in urinary cancers.

Methods: Relevant articles were searched comprehensively from PubMed, Embase and Web of Science, up to November 2018. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted to evaluate their associations. Read More

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http://dx.doi.org/10.1186/s12935-018-0708-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296044PMC
December 2018
2 Reads
1.989 Impact Factor

Identification of biomarkers of chromophobe renal cell carcinoma by weighted gene co-expression network analysis.

Cancer Cell Int 2018 17;18:206. Epub 2018 Dec 17.

Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Road, Shanghai, 200127 China.

Background: Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear cell renal cell carcinoma (nccRCC), which accounting for 4-5% of renal cell carcinoma (RCC). However, there is no effective bio-marker to predict clinical outcomes of this malignant disease. Bioinformatic methods may provide a feasible potential to solve this problem. Read More

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http://dx.doi.org/10.1186/s12935-018-0703-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296159PMC
December 2018
1 Read

Cancer cells arise from bacteria.

Cancer Cell Int 2018 14;18:205. Epub 2018 Dec 14.

Department of Bioengineering, Hebei University of Technology, Tianjin, 300130 China.

Background: The origin of cancer cells is the most fundamental yet unresolved problem in cancer research. Cancer cells are thought to be transformed from the normal cells. However, recent studies reveal that the primary cancer cells (PCCs) for cancer initiation and secondary cancer cells (SCCs) for cancer progression are formed in but not transformed from the senescent normal and cancer cells, respectively. Read More

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http://dx.doi.org/10.1186/s12935-018-0699-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295013PMC
December 2018
1 Read

HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-β/smad signaling pathway in cervical carcinoma cells.

Cancer Cell Int 2018 12;18:204. Epub 2018 Dec 12.

2Department of Imaging, The Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfu Front Street, Erqi District, Zhengzhou, 450052 Henan Province People's Republic of China.

Background: Homeobox C6 (HOXC6) plays a part in malignant progression of some tumors. However, the expression of HOXC6 and its clinical significance remains unclear in cervical carcinoma (CC). The purpose of this study is to verify the effects of HOXC6 gene silencing on CC through the TGF-β/smad signaling pathway. Read More

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http://dx.doi.org/10.1186/s12935-018-0680-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290547PMC
December 2018
1 Read
1.989 Impact Factor

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas.

Cancer Cell Int 2018 11;18:203. Epub 2018 Dec 11.

1Research Group of Gastrointestinal Diseases, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan China.

Background: Emerging evidence has suggested that interleukin (IL)-33 and its primary functional receptor ST2 are involved in the pathogenesis of tumorigenesis.

Methods: Using immunohistochemistry (IHC) and double immunofluorescence staining, we characterized the cellular and clinicopathological features of the IL-33/ST2 axis in different compartments in human esophageal squamous cell carcinoma (ESCC) surgical specimens.

Results: IHC data revealed an increased expression of IL-33-immunoreactivity (IR) and ST2-IR located in both ESCC cells and tumor stromal cells; which were associated with advanced clinicopathological features such as TNM stages and node involvement. Read More

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http://dx.doi.org/10.1186/s12935-018-0700-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290492PMC
December 2018
1 Read

TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathway.

Cancer Cell Int 2018 11;18:202. Epub 2018 Dec 11.

Department of Gastroenterology, Yiwu Hospital, Wenzhou Medical University, 699 Jiangdong Middle Road, Yiwu, 322000 China.

Background: Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the pathogenesis of various cancers. This study aimed to investigate TRIM14 expression in CRC tissues, and its effects on the migration and invasion of CRC cell lines. Read More

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http://dx.doi.org/10.1186/s12935-018-0701-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288942PMC
December 2018
1 Read

MicroRNA-218-5p inhibits cell growth and metastasis in cervical cancer via /NF-κB signaling pathway.

Cancer Cell Int 2018 4;18:198. Epub 2018 Dec 4.

4Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou, 325000 Zhejiang China.

Background: We are committed to investigate miR-218-5 effects on the progression of cervical cancer (CC) cell and find out the molecular mechanism.

Methods: GSE9750 was obtained from GEO database and R Limma package was applied to filter out dysregulated genes. The pathways were enriched by GSEA software, ClusterProfiler and enrichplot packages to predict the function of DEGs. Read More

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http://dx.doi.org/10.1186/s12935-018-0673-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278036PMC
December 2018
1 Read
1.989 Impact Factor

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2.

Cancer Cell Int 2018 3;18:196. Epub 2018 Dec 3.

1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background: RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been found associated with a number of nervous system diseases. However, the role of ADAR3, a brain specific high expression adenosine deaminase, in gliomas has rarely been investigated. Read More

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http://dx.doi.org/10.1186/s12935-018-0695-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276233PMC
December 2018
1 Read

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma.

Cancer Cell Int 2018 3;18:195. Epub 2018 Dec 3.

6Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061 People's Republic of China.

Background: MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resistance. However, the role and underlying molecular mechanism of miR-770 in human glioma remain unknown and need to be further elucidated. Read More

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http://dx.doi.org/10.1186/s12935-018-0694-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276177PMC
December 2018
1 Read

Prognostic impact of pretreatment lymphocyte-to-monocyte ratio in advanced epithelial cancers: a meta-analysis.

Cancer Cell Int 2018 6;18:201. Epub 2018 Dec 6.

1Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Gusu District, Suzhou, 215004 China.

Background: There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been suggested to indicate favorable prognoses in various epithelial cancers. We performed a meta-analysis to quantify the prognostic value of LMR in advanced-stage epithelial cancers undergoing various treatment. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-018-0698-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282251PMC
December 2018
3 Reads

ERK-mediated autophagy promotes inactivated Sendai virus (HVJ-E)-induced apoptosis in HeLa cells in an Atg3-dependent manner.

Cancer Cell Int 2018 4;18:200. Epub 2018 Dec 4.

1Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, 12 Wenhui East Road, Yangzhou, 225009 China.

Background: Apoptosis and autophagy are known to play important roles in cancer development. It has been reported that HVJ-E induces apoptosis in cancer cells, thereby inhibiting the development of tumors. To define the mechanism by which HVJ-E induces cell death, we examined whether HVJ-E activates autophagic and apoptotic signaling pathways in HeLa cells. Read More

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http://dx.doi.org/10.1186/s12935-018-0692-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280409PMC
December 2018
1 Read