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    943 results match your criteria Cancer Cell International [Journal]

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    Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells.
    Cancer Cell Int 2018 20;18:25. Epub 2018 Feb 20.
    2Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Road, Bangkok Noi, Bangkok, 10700 Thailand.
    Background: Cholangiocarcinoma (CCA) is one of the worst prognosis cancer. The survival time of CCA patients is related to serum estrogen levels and estrogen has been found to enhance the proliferation and invasiveness of CCA cells in vitro. This has led to the suggestion that estrogen may play an important role in the progression of CCA. Read More

    Catalase down-regulation in cancer cells exposed to arsenic trioxide is involved in their increased sensitivity to a pro-oxidant treatment.
    Cancer Cell Int 2018 20;18:24. Epub 2018 Feb 20.
    1Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, MNUT 7309, LDRI, UCL Avenue E. Mounier 73, 1200 Brussels, Belgium.
    Background: Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying resistance to oxidative stress, we found that the chronic exposure to an HO-generating system (ascorbate/menadione, Asc/Men) or catalase overexpression (CAT3 cells) increased the resistance of cancer cells to oxidative stress, likely by increasing the antioxidant status of cancer cells.

    Methods: Modulation of catalase expression was performed by either protein overexpression or protein down-regulation using siRNA against catalase and aminotriazole as pharmacological inhibitor. Read More

    Depletion of membrane cholesterol compromised caspase-8 imparts in autophagy induction and inhibition of cell migration in cancer cells.
    Cancer Cell Int 2018 20;18:23. Epub 2018 Feb 20.
    Indian Veterinary Research Institute, Bareilly, India.
    Background: Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell death after cholesterol depletion than normal cells. Methyl-β-cyclodextrin (MβCD), an amphipathic polysaccharide known to deplete the membrane cholesterol, induces cell death selectively in cancer cells. Read More

    Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC).
    Cancer Cell Int 2018 20;18:22. Epub 2018 Feb 20.
    1Department of Head and Neck Surgery, Zhejiang Cancer Hospital, No. 38 Guangji Road, Hangzhou, 310022 Zhejiang China.
    Background: Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC). This study aims to decipher the prognostic and mechanistic role of PIM1 in progression of SACC cells and tumor tissues.

    Methods: A SACC cell line (ACC-M) was transfected with shRNA plasmids targeting the PIM1 gene. Read More

    Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy.
    Cancer Cell Int 2018 17;18:21. Epub 2018 Feb 17.
    1Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children, Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Beijing, 100045 China.
    Background: We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.

    Methods: Marrow blood samples from NB patients were collected before treatment, after the 2nd and 4th chemotherapy for baseline research and continuous monitoring by whole exome sequencing. Plasma cell free DNA (cfDNA) was prepared for baseline research. Read More

    RRS1 gene expression involved in the progression of papillary thyroid carcinoma.
    Cancer Cell Int 2018 13;18:20. Epub 2018 Feb 13.
    1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
    Background: Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body of evidences highlights ribosome biogenesis regulator homolog (RRS1) as a ribosome biogenesis protein in yeast and plants, little is known about human RRS1 function.

    Methods: Proliferation, cell cycle and apoptosis of PTC cells were assessed following the knockdown of RRS1 expression though MTT, colony formation assay, and flow cytometry. Read More

    Cumulative receiver operating characteristics for analyzing interaction between tissue visfatin and clinicopathologic factors in breast cancer progression.
    Cancer Cell Int 2018 9;18:19. Epub 2018 Feb 9.
    Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: Visfatin has been reported to be associated with breast cancer progression, but the interaction between the visfatin and clinicopathologic factors in breast cancer progression status requires further investigation. To address this problem, it is better to simultaneously consider multiple factors in sensitivity and specificity assays.

    Methods: In this study, a dataset for 105 breast cancer patients (84 disease-free and 21 progressing) were chosen. Read More

    miR-29b enhances prostate cancer cell invasion independently of MMP-2 expression.
    Cancer Cell Int 2018 5;18:18. Epub 2018 Feb 5.
    1Laboratory of Medical Investigation (LIM55), Urology Department, University of Sao Paulo Medical School, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, 01246-903 Brazil.
    Background: The ability to metastasize is one of the most important characteristics of neoplastic cells. An imbalance between the action of some matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs drives the invasion process. Some studies have suggested that MMP-2 is involved in metastasis, while other studies have reported that collagen production by cancer cells might also contribute to motility. Read More

    Correction to: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line.
    Cancer Cell Int 2018 31;18:17. Epub 2018 Jan 31.
    1Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University, No. 6, Beijing Road West, Huai'an, 223300 People's Republic of China.
    [This corrects the article DOI: 10.1186/s12935-017-0478-7.]. Read More

    MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression.
    Cancer Cell Int 2018 30;18:16. Epub 2018 Jan 30.
    1Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, 215004 Jiangsu China.
    Background: Recent studies have shown that laminin subunit alpha 4 (LAMA4) plays an important role in carcinogenesis. However, its molecular biological function in triple-negative breast cancer (TNBC) has not been entirely clarified. This study investigated the expression of LAMA4 in TNBC and its effect on cell proliferation, migration and invasion. Read More

    Imiquimod inhibits growth and induces differentiation of myeloid leukemia cell lines.
    Cancer Cell Int 2018 30;18:15. Epub 2018 Jan 30.
    2Departamento de Microbiología y Ecología, Universitat de València, Burjasot, Spain.
    Background: The antitumoral effects of different Toll-like receptor (TLRs) agonists is mediated by activating immune responses to suppress tumors growth, although TLR ligands may also have a direct effect on tumoral cells. Given that TLR signaling induces hematopoietic cell differentiations this may serve as a novel differentiation therapeutic approach for AML.

    Methods: We investigated the effects of agonists for the ten human TLRs on the proliferation, apoptosis, cell cycle and differentiation of ten different types of myeloid leukemia cell lines (HL-60, U-937, KG-1, KG-1a, K-562, Kasumi-1, EOL-1, NB4, MOLM-13 and HEL). Read More

    Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles.
    Cancer Cell Int 2018 30;18:14. Epub 2018 Jan 30.
    1Cancer and Metabolism Laboratory, Faculty of Medicine, Saint Joseph University, Damascus Road, Riad el Solh, Beirut, 1107 2180 Lebanon.
    Background: p53 is a tumor suppressor and key regulator of glycolysis in cancer cells, however highly mutated in tumors. In ovarian cancer, studies concerning p53 mutations focus on the DNA binding domain since the majority of hotspot mutations affects this region. Yet, mutations in other regions such as the proline rich domain may also affect the protein's expression and activity. Read More

    Down regulation of G protein-coupled receptor 137 expression inhibits proliferation and promotes apoptosis in leukemia cells.
    Cancer Cell Int 2018 29;18:13. Epub 2018 Jan 29.
    Zhong Yuan Academy of Biological Medicine, Liaocheng University, Liaocheng People's Hospital, Medical School of Liaocheng, Liaocheng, 252000 Shandong Province P. R. China.
    Background: G protein-coupled receptors (GPR) are involved in a wide range of physiological processes, some of which, however, can be hijacked by tumor cells. Over-expression of G protein-coupled receptors 137 (GPR137) are associated with the growth of tumor cells, but under-expression of GPR137 has shown to inhibit cell proliferation in several different types of cancers. Currently, the role of GPR137 in leukemia is still unclear. Read More

    C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells.
    Cancer Cell Int 2018 25;18:12. Epub 2018 Jan 25.
    Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, 308 Ningxia Road, Qingdao, 266071 China.
    Background: Triple-negative breast cancer is a biological subtype of breast cancer, which is unresponsive to conventional chemotherapies and has a poor prognosis. C-Phycocyanin (C-PC), a marine natural purified from, has been investigated that has anti-cancer function. The mitogen activated protein kinase (MAPK) pathway plays a crucial role in the development and progression of cancer. Read More

    Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression.
    Cancer Cell Int 2018 23;18:11. Epub 2018 Jan 23.
    1Department of Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006 Jiangsu China.
    Background: Exosomes mediated transfer of lncRNA 91H may play a critical role in the development of CRC. However, few studies have proved the mechanism. So we performed this study to deeply explore the biological functions of exosomal 91H in the development and progression of CRC. Read More

    MicroRNA-10b regulates epithelial-mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma.
    Cancer Cell Int 2018 17;18:10. Epub 2018 Jan 17.
    1Department of Medical Oncology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830000 People's Republic of China.
    Background: Our previous work showed that miR-10b was overexpressed in hepatocellular carcinoma (HCC) and promoted HCC cell migration and invasion. Epithelial-mesenchymal transition (EMT) is involved in HCC metastasis. So, we suspected that miR-10b might participate in the HCC EMT. Read More

    Xenogeneic cell therapy provides a novel potential therapeutic option for cancers by restoring tissue function, repairing cancer wound and reviving anti-tumor immune responses.
    Cancer Cell Int 2018 16;18. Epub 2018 Jan 16.
    1Department of Urology, Graduate Institute of Clinical Medical Science, China Medical University and Hospital, 40454, Taichung, Taiwan.
    Conventional cancer treatments such as surgery, radiotherapy, chemotherapy and targeted therapy, not only destruct tumors, but also injure the normal tissues, resulting in limited efficacy. Recent advances in cancer therapy have aimed at changing the host milieu of cancer against its development and progression by targeting tumor microenvironment and host immune system to eradicate tumors. To the host body, tumors arise in tissues. Read More

    SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer.
    Cancer Cell Int 2018 15;18. Epub 2018 Jan 15.
    Department of Obstetrics and Gynecology, Taizhou First People's Hospital, Hengjie Road, No 218, Huangyan, Taizhou, 318020 Zhejiang China.
    Background: Autophagy is a cell degradation pathway that eliminates damaged or unwanted proteins and organelles. Autophagy protects cells from chemotherapeutic agents by scavenging damaged mitochondria.

    Methods: Plasmid transfection and shRNA were used to regulate SHP-2 expression. Read More

    A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery.
    Cancer Cell Int 2018 15;18. Epub 2018 Jan 15.
    1Department of Surgical Sciences, Umberto I Hospital, "Sapienza" University of Rome, viale Regina Elena 324, 00161 Rome, Italy.
    Background: Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxidative stress in thyroid cancer by analyzing the expression of two selenium antioxidant molecules, glutathione peroxidase (GPx1) and thioredoxin reductase (TrxR1) in thyroid cancer cells. Read More

    A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma.
    Cancer Cell Int 2018 8;18. Epub 2018 Jan 8.
    Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, 140, Hanzhong Road, Nanjing, 210029 People's Republic of China.
    Background: Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies. However, little is known about the biological effect and the clinical implication of these reported mutations. Read More

    MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma.
    Cancer Cell Int 2018 4;18. Epub 2018 Jan 4.
    Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045 China.
    Background: Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood.

    Methods: Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of miR-20a-5p and its target gene ATG7 in clinical NB tissues. Read More

    Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line.
    Cancer Cell Int 2018 4;18. Epub 2018 Jan 4.
    Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University, No. 6, Beijing Road West, Huai'an, 223300 People's Republic of China.
    Objective: This study aims to investigate the effect of long non-coding RNA (lncRNA) Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer (CRC) HT-29 cell line.

    Methods: CRC and normal tissues were collected and prepared from a total of 126 CRC patients, and normal intestinal epithelial cell line FHC and CRC cell lines (HCT-8, HT-29, HCT-116 and SW-480) were prepared. Gas5 expression was detected by quantitative reverse transcriptase-polymerase chain reaction. Read More

    Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate.
    Cancer Cell Int 2018 4;18. Epub 2018 Jan 4.
    Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road 600, Guangzhou, 510630 China.
    Background: Primary malignant lymphoma of the prostate (PMLP) is prone to occur in the elderly, and it has no significant correlation with lactate dehydrogenase (LDH) and prostate specific antigen (PSA). Clinical symptoms and imaging data of PMLP remain unspecific, and its prognosis is poor. A previous result showed that collapsin response mediator protein 4 (CRMP4) promotor methylation can be used as a predictor for lymph node metastases in prostate biopsies. Read More

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    Cancer Cell Int 2018 3;18. Epub 2018 Jan 3.
    Peripheral Neuropathy Research Center, Department of Physiology, College of Medicine, Dong-A University, Dongdaesin-Dong, Seo-Gu, Busan, 602-714 South Korea.
    Background: Autophagy is a response to cellular and environmental conditions and facilitates cell survival. Here, we investigated the role of ectopic expression of microRNA (miRNA) 200c-3p in autophagy.

    Methods: miRNA mimics were used to overexpress miRNAs. Read More

    Prognostic and clinicopathological significance of long noncoding RNA HOXA11-AS expression in human solid tumors: a meta-analysis.
    Cancer Cell Int 2018 3;18. Epub 2018 Jan 3.
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
    Background: Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers.

    Patients/methods: We systematically searched PubMed, Embase, ISI Web of Science, and SCOPUS for relevant studies, to investigate the prognostic significance of HOXA11-AS expression in cancer patients. Read More

    Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway.
    Cancer Cell Int 2017 28;17:124. Epub 2017 Dec 28.
    The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.
    Background: Cisplatin is one of the first-line drugs for urothelial bladder cancer (UBC) treatment. However, its considerable side effects and the emergence of drug resistance are becoming major limitations for its application. This study aimed to investigate whether matrine and cisplatin could present a synergistic anti-tumor effect on UBC cells. Read More

    Study of the tumor microenvironment during breast cancer progression.
    Cancer Cell Int 2017 22;17:123. Epub 2017 Dec 22.
    Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
    Background: Different cells and mediators in the tumor microenvironment play important roles in the progression of breast cancer. The aim of this study was to determine the composition of the microenvironment during tumor progression in order to discover new related biomarkers and potentials for targeted therapy.

    Methods: In this study, breast cancer biopsies from four different stages, and control breast biopsies were collected. Read More

    Establishment and evaluation of four different types of patient-derived xenograft models.
    Cancer Cell Int 2017 20;17:122. Epub 2017 Dec 20.
    Guangdong Laboratory Animals Monitoring Institute, Guangdong Key Laboratory Animal Lab, 11 Fengxin Road, Science City, Guangzhou, 510663 China.
    Background: Patient-derived xenografts (PDX) have a biologically stable in tumor architecture, drug responsiveness, mutational status and global gene-expression patterns. Numerous PDX models have been established to date, however their thorough characterization regarding the tumor formation and rates of tumor growth in the established models remains a challenging task. Our study aimed to provide more detailed information for establishing the PDX models successfully and effectively. Read More

    The human, F-actin-based cytoskeleton as a mutagen sensor.
    Cancer Cell Int 2017 12;17:121. Epub 2017 Dec 12.
    Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Bruce B. Downs Bd., Tampa, FL 12901 USA.
    Background: Forty years ago the actin cytoskeleton was determined to be disrupted in fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear connection between the cytoskeleton and DNA repair defects at that time. Recently, the large number of sequenced genomes has indicated that mammalian mutagenesis has a large stochastic component. As a result, large coding regions are large mutagen targets. Read More

    Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells.
    Cancer Cell Int 2017 11;17:120. Epub 2017 Dec 11.
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717 Japan.
    Background: Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated activities of several enzymes involved in nucleic acid metabolism.

    Methods: We established two kinds of PEM-resistant mesothelioma cells which did not show any increase of the relevant enzyme activities. Read More

    Erythropoietin promoted the proliferation of hepatocellular carcinoma through hypoxia induced translocation of its specific receptor.
    Cancer Cell Int 2017 11;17:119. Epub 2017 Dec 11.
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China.
    Background: Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who receive chemotherapy. Several reports indicated that it could promote the tumor cell proliferation through its specific receptor (EPOR). Read More

    miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling.
    Cancer Cell Int 2017 8;17:118. Epub 2017 Dec 8.
    Department of Hepatobiliary Surgery, First People's Hospital of Kunming City, No. 504 Qinnian Road, Kunming, 650034 Yunnan China.
    Background: Hepatocellular carcinoma (HCC) remains one of the most lethal cancers. MicroRNA-155 (miR-155) and collagen triple helix repeat containing 1 (CTHRC1) were found to be involved in hepatocarcinogenesis, but their detailed functions in HCC are unclear. Here, we aimed to investigate the underlying role of miR-155-5p and CTHRC1 in HCC. Read More

    Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma.
    Cancer Cell Int 2017 4;17:117. Epub 2017 Dec 4.
    Neurosurgical Department, Shanghai Tenth People's Hospital, Tongji University, 301 Middle Yanchang Road, Shanghai, 200072 China.
    Background: Chemoresistance of glioblastoma (GBM) is a feature of this devastating disease. This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ) in human GBM.

    Methods: We analyzed Gli1 nuclear staining and O-methylguanine DNA methyltransferase (MGMT) expression in 48 cases of primary GBM tissues by immunohistochemistry. Read More

    Anticancer activity ofpolysaccharide in human non-small cell lung cancer cells.
    Cancer Cell Int 2017 4;17:115. Epub 2017 Dec 4.
    Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuchang District, Wuhan, 430071 Hubei China.
    Background: We have reported that Chinese herbspolysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesis, growth, development and metastasis of cancer. NF-κB is also involved in the development of treatment resistance in tumors. Read More

    Increased expression of MARCH8, an E3 ubiquitin ligase, is associated with growth of esophageal tumor.
    Cancer Cell Int 2017 4;17:116. Epub 2017 Dec 4.
    University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector-16(C), Dwarka, Delhi, 110078 India.
    Background: Herein, for the first time, we report aberrant expression of membrane-associated RING-CH8 (MARCH8) in human esophageal squamous cell carcinoma. MARCH8 is a member of the recently discovered MARCH family of really interesting new genes (RING) E3 ligases. Though initial studies primarily focused on its immunomodulatory role, the newly discovered targets of this E3 ligase point towards its possible role in other biological processes such as embryogenesis and inhibition of apoptosis. Read More

    Tumor-infiltrating CD4T cells in patients with gastric cancer.
    Cancer Cell Int 2017 2;17:114. Epub 2017 Dec 2.
    Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
    Background: T lymphocytes play an indispensably important role in clearing virus and tumor antigen. There is little knowledge about impacts of inhibitory molecules with cytokine on tumor-infiltrating CD4T-cells in the presence of gastric cancer (GC). This study investigated the distribution of tumor-infiltrating T-cells subset and the differentiation as well as inhibitory phenotype of T-cells from blood and tissues of GC patients. Read More

    CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling.
    Cancer Cell Int 2017 29;17:113. Epub 2017 Nov 29.
    Department of Surgical Oncology, The First Affiliated Hospital Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, 710061 Shaanxi People's Republic of China.
    Background: Human chemokine like factor (CKLF)-like MAL and related proteins for vesicle trafficking transmembrane, domain-containing member 5 (CMTM5) has been shown to involved and may function as a tumour suppressor in tumorigenesis. The current study aimed to investigate the expression and function of CMTM5 in human hepatocellular carcinoma (HCC).

    Methods: CMTM5 expression was examined by immunohistochemistry, and its clinical significance was analysed in 76 HCC specimens. Read More

    ROR2 receptor promotes the migration of osteosarcoma cells in response to Wnt5a.
    Cancer Cell Int 2017 29;17:112. Epub 2017 Nov 29.
    Spine Surgery, Third Affiliated Hospital of Soochow University, Changzhou, 213003 Jiangsu China.
    Background: We have reported that the phosphatidylinositol-3 kinase (PI3K)/Akt/RhoA signaling pathway mediates Wnt5a-induced cell migration of osteosarcoma cells. However, the specific receptors responding to Wnt5a ligand remain poorly defined in osteosarcoma metastasis.

    Methods: Wound healing assays were used to measure the migration rate of osteosarcoma cells transfected with shRNA or siRNA specific against ROR2 or indicated constructs. Read More

    RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition.
    Cancer Cell Int 2017 28;17:111. Epub 2017 Nov 28.
    Universidad de Buenos Aires, Facultad de Medicina, Instituto de Investigaciones Médicas A Lanari, Buenos Aires, Argentina.
    Background: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents. The aim of this study was to investigate its role in chemoresistance of colorectal cancer. Read More

    Natural agents mediated autophagic signal networks in cancer.
    Cancer Cell Int 2017 28;17:110. Epub 2017 Nov 28.
    Peripheral Neuropathy Research Center, Department of Physiology, College of Medicine, Dong-A University, Dongdaesin-Dong, Seo-Gu, Busan, 602-714 Republic of Korea.
    Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy ("self-eating") plays important roles in multiple diseases and acts as a tumor suppressor in cancer. Here, we examined the molecular mechanism by which natural agents regulate autophagic signals. Read More

    Inhibition of breast cancer cell proliferation and tumorigenesis by long non-coding RNAdown-regulation of miR-122 expression.
    Cancer Cell Int 2017 21;17:109. Epub 2017 Nov 21.
    Department of Breast Surgery, Xiangya Hospital Central South University, No. 87 Xiangya Road, Changsha, 410008 China.
    Background: Recent studies showed that long non-coding RNA (lncRNA) plays an important role in many life activities.is one of the lncRNA genes that are expressed differently between breast cancer and normal tissues by the lncRNA gene chip. Our study was conducted to examine the regulation of lncRNAin breast cancer. Read More

    Volatile organic metabolites identify patients with gastric carcinoma, gastric ulcer, or gastritis and control patients.
    Cancer Cell Int 2017 21;17:108. Epub 2017 Nov 21.
    Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, No. 150 Haping Rd., Nangang District, Harbin, 150081 China.
    Background: Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In addition, its clinical symptoms often do not match the corresponding stage. Read More

    Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma.
    Cancer Cell Int 2017 21;17:107. Epub 2017 Nov 21.
    Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China.
    Background: Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought to determine the therapeutic efficiency of PTC-209, a potent and selective Bmi1 inhibitor, in head neck squamous cell carcinoma (HNSCC) cells and a HNSCC xenograft model.

    Methods: The mutation pattern, mRNA level of Bmi1 in HNSCC and its associations with clinicopathological parameters were determined through comprehensive data mining and interrogation using publicly available databases GENT, cBioPortal, Oncomine and TCGA. Read More

    Microencapsulation of low-passage poorly-differentiated human mucoepidermoid carcinoma cells by alginate microcapsules: in vitro profiling of angiogenesis-related molecules.
    Cancer Cell Int 2017 21;17:106. Epub 2017 Nov 21.
    Medical Beauty Department, Suining Central Hospital, No. 127, Western Desheng Road, Suining, 629000 Sichuan China.
    Background: Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly differentiated cancer cells of high-grade MEC, contributes to tumor growth and metastasis. Read More

    Role of microRNA-33a in regulating the expression of PD-1 in lung adenocarcinoma.
    Cancer Cell Int 2017 17;17:105. Epub 2017 Nov 17.
    Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Roma 57, 56126 Pisa, Italy.
    Background: MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cytotoxic T-lymphocyte antigen 4) have proven to be beneficial against several solid tumors, including lung adenocarcinoma.

    Methods: Simultaneous quantification of the expression level of miR-33a and-,-andmRNAs with NanoString technology was performed in 88 lung adenocarcinoma specimens. Read More

    Restoration of miR-29b exerts anti-cancer effects on glioblastoma.
    Cancer Cell Int 2017 17;17:104. Epub 2017 Nov 17.
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
    Background: Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 subfamilies are known to be exclusively expressed in the developing brain, and they are aberrantly down-regulated in GBM. Read More

    CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma.
    Cancer Cell Int 2017 14;17:103. Epub 2017 Nov 14.
    The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510275 Guangdong People's Republic of China.
    Background: Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80-90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem cells (CSCs) are proposed to be responsible for failure of current treatment. Read More

    MicroRNA-214-3p inhibits proliferation and cell cycle progression by targeting MELK in hepatocellular carcinoma and correlates cancer prognosis.
    Cancer Cell Int 2017 7;17:102. Epub 2017 Nov 7.
    Institute of Antibody Engineering, Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, 510515 China.
    Background: MicroRNAs are considered as potential regulators in various biological pathways and contribute to the diagnosis and prognosis of cancers. MicroRNA-214-3p (miR-214-3p) was proved to be correlated with various cancers in recent studies. However, the biological functions of miR-214-3p in hepatocellular carcinoma (HCC) and its association with the prognosis of HCC after liver transplantation are still unevaluated. Read More

    Targeting deubiquitinating enzymes in cancer stem cells.
    Cancer Cell Int 2017 3;17:101. Epub 2017 Nov 3.
    Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.
    Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. Read More

    MiR-20a-5p represses the multi-drug resistance of osteosarcoma by targeting the SDC2 gene.
    Cancer Cell Int 2017 2;17:100. Epub 2017 Nov 2.
    Cancer Epigenetics Program, Anhui Cancer Hospital, West Branch of Anhui Provincial Hospital, Anhui Medical University, Hefei, 230031 Anhui China.
    Background: As one of the hallmarks of cancer, chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS). MicroRNAs (miRNAs) act as key regulators of gene expression in diverse biological processes including the multi-chemoresistance of cancers.

    Methods: Based on the CCK8 experiments, we performed an RNA-seq-based miR-omic analysis of osteosarcoma (OS) cells (a multi-chemosensitive OS cell line G-292 and a multi-chemoresistant OS cell line SJSA-1) to detect the levels of miR-20a-5p. Read More

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