997 results match your criteria Cancer Cell International [Journal]


Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147.

Cancer Cell Int 2018 7;18:80. Epub 2018 Jun 7.

3Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, 30 South Renmin Road, Shiyan, 442000 Hubei People's Republic of China.

Background: Increased expression of integrin β1 has been reported to correlate with progression and therapy resistance in many types of cancers. The aim of this study was to investigate the effects of integrin β1 on the invasion and radioresistance of laryngeal cancer cells.

Methods: The expression of integrin β1 in the tumor specimens of laryngeal cancer patients was assessed by immunohistochemical assays. Read More

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Silencing Formin-like 2 inhibits growth and metastasis of gastric cancer cells through suppressing internalization of integrins.

Cancer Cell Int 2018 1;18:79. Epub 2018 Jun 1.

Department of Gastric, Intestine and Hernia Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001 People's Republic of China.

Background: Formin-like 2 (FMNL2) is a member of Formin family which governs cytokinesis, cellular polarity and morphogenesis. Dysregulation of FMNL2 has been discovered in cancers and is closely related to cancers. However, the role of FMNL2 in gastric cancer remains unclear. Read More

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APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.

Cancer Cell Int 2018 29;18:78. Epub 2018 May 29.

1Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Rd, 200011 Shanghai, People's Republic of China.

Background: Ovarian cancer is a heterogeneous disease with a high degree of genomic instability, pro-/antitumor immunity and inflammation, and remains the most lethal gynecologic cancer worldwide. APOBEC3B, a member of the AID/APOBEC family, is part of the innate immune system which plays a key role in combating exogenous infection especially viral infection. Studies have shown that APOBEC3B expression is elevated in a variety of cancer tissues and cell lines, and plays a prominent role in the genesis and evolution of various cancers. Read More

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In situ characterization of stem cells-like biomarkers in meningiomas.

Cancer Cell Int 2018 25;18:77. Epub 2018 May 25.

2King Fahd Medical Research Center, King Abdulaziz University, P.O. Box. 80216, Jeddah, 21589 Saudi Arabia.

Background: Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Successful therapies developed for inoperable, recurrent, or metastatic tumors must target these cells and restrict their contribution to tumor progression. Unfortunately, the identity of MCSCs remains elusive, and MSCSs' in situ spatial distribution, heterogeneity, and relationship with tumor grade, remain unclear. Read More

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Overexpression of long non-coding RNA SOX2OT promotes esophageal squamous cell carcinoma growth.

Cancer Cell Int 2018 25;18:76. Epub 2018 May 25.

1Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University or Army Medical University, Chongqing, China.

Background: SOX2 overlapping transcript (SOX2OT) has been reported to be an important lncRNA in various cancers. SOX2 is embedded in an intron of the SOX2OT gene. But the role of SOX2OT in esophageal squamous cell carcinoma (ESCC) and the association between SOX2OT and SOX2 remain unclear. Read More

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May 2018
2 Reads

Correction to: CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma.

Cancer Cell Int 2018 11;18:73. Epub 2018 May 11.

5The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510275 Guangdong People's Republic of China.

[This corrects the article DOI: 10.1186/s12935-017-0473-z.]. Read More

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Up-regulation of CTD-2547G23.4 in hepatocellular carcinoma tissues and its prospective molecular regulatory mechanism: a novel qRT-PCR and bioinformatics analysis study.

Cancer Cell Int 2018 11;18:74. Epub 2018 May 11.

2Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Zhuang Autonomous Region People's Republic of China.

Background: Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in the pathogenesis and progression of multiple cancers, including hepatocellular carcinoma (HCC). LncRNA CTD-2547G23.4 is a novel lncRNA, and its role in HCC is still unknown. Read More

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May 2018
7 Reads

miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L.

Cancer Cell Int 2018 9;18:72. Epub 2018 May 9.

Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, 194 Xuefu Road, Harbin, 150001 Heilongjiang China.

Background: Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignancies that affects lacrimal gland. MicroRNAs are known to play a crucial role as oncogenes or tumor suppressors. Specifically, miR-93 has been reported to play a crucial role in colorectal, breast, pancreatic, lung cancer and hepatocellular carcinoma. Read More

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May 2018
2 Reads

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

Cancer Cell Int 2018 9;18:71. Epub 2018 May 9.

Cancer Sciences Unit and Cancer Research UK Centre, University of Southampton, Southampton General Hospital, Somers Cancer Research Building, Mailpoint 824, Southampton, SO16 6YD UK.

Background: Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such as enzalutamide as a result. The lysine demethylase LSD1 is a co-activator of the wild type androgen receptor and a potential therapeutic target in hormone sensitive prostate cancer. We evaluated whether LSD1 could also be therapeutically targeted in CRPC models driven by AR-V7. Read More

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LncRNA PVT1 promotes the growth of HPV positive and negative cervical squamous cell carcinoma by inhibiting TGF-β1.

Cancer Cell Int 2018 8;18:70. Epub 2018 May 8.

1Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000 Shandong People's Republic of China.

Background: Our study aimed to investigate the role of lncRNA PVT1 in cervical squamous cell carcinoma.

Materials And Methods: A total of 156 patients with cervical squamous cell carcinoma were enrolled in this study and human papillomavirus (HPV) infection was detected by highly sensitive PCR techniques. Serum levels of PVT1 in patients infected with different HPVs and healthy controls was detected by qRT-PCR and compared. Read More

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Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs.

Cancer Cell Int 2018 4;18:69. Epub 2018 May 4.

3Applied Pharmacy, University of Applied Sciences Kaiserslautern, Campus Pirmasens, Carl-Schurz-Str. 10-16, 66953 Pirmasens, Germany.

Background: Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resistance is still not clear. Here, we aimed at determining the activation status of these pathways in human GBM biopsies and cells and investigating the quantitative impact of both pathways to chemoresistance. Read More

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Prognostic significance of CXCL5 expression in cancer patients: a meta-analysis.

Cancer Cell Int 2018 2;18:68. Epub 2018 May 2.

1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: CXCL5 is a member of the CXC-type chemokine family, which has been found to play important roles in tumorigenesis and cancer progression. Recent studies have demonstrated that CXCL5 could serve as a potential prognostic biomarker for cancer patients. However, the prognostic value of CXCL5 is still controversial. Read More

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Analysis of the role of rs2031920 and rs3813867 polymorphisms within the gene in the risk of squamous cell carcinoma.

Cancer Cell Int 2018 1;18:67. Epub 2018 May 1.

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, No 6, Ji Zhao Road, Jinnan District, Tianjin, 300060 People's Republic of China.

Background: To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 () gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.

Methods: The eligible case-control studies were obtained by database searching and screening, and the specific statistical analysis was performed with STATA 12.0 software. Read More

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May 2018
2 Reads

miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2.

Cancer Cell Int 2018 1;18:66. Epub 2018 May 1.

Department of Gastroenterological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032 China.

Background: MicroRNAs deregulation are common in human tumor progression. miR-1236-3p has been reported to function as tumor suppressor microRNA in various malignancies. The aim of this study was to demonstrate the downregulated expression of miR-1236-3p in gastric cancer (GC) tissues and cell lines, and clarify its biological function in GC. Read More

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May 2018
1 Read

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer.

Cancer Cell Int 2018 1;18:65. Epub 2018 May 1.

Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, 6/F Professorial Block, Pokfulam, Hong Kong, SAR China.

Background: Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is the main stay of treatment for metastatic disease, with modest response rates but significant side effects. Therefore, there is a need for alternative therapies that can control the disease while offering good quality of life. Read More

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May 2018
1 Read

MicroRNA-365 promotes lung carcinogenesis by downregulating the USP33/SLIT2/ROBO1 signalling pathway.

Cancer Cell Int 2018 1;18:64. Epub 2018 May 1.

1Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 Guangdong China.

Background: Abnormal microRNA expression is closely related to cancer occurrence and development. miR-365a-3p plays an oncogenic role in skin cancer, but its role in lung cancer remains unclear. In this study, we aimed to investigate its role and underlying molecular mechanisms in lung cancer. Read More

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Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors.

Cancer Cell Int 2018 24;18:63. Epub 2018 Apr 24.

Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy.

Background: A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeutic responses in several types of cancer, including neuroblastoma (NB). Therefore, RTKs targeting is a worthwhile challenge for the oncologists. Read More

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Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017.

Cancer Cell Int 2018 23;18:62. Epub 2018 Apr 23.

1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Dadao, Wuhan, 430022 China.

Background: Despite recent advances, multiple myeloma (MM) remains incurable. However, the appearance of allogeneic stem cell transplantation (allo-SCT) through graft-versus-myeloma effect provides a potential way to cure MM to some degree. This systematic review aimed to evaluate the outcome of patients receiving allo-SCT and identified a series of prognostic factors that may affect the outcome of allo-SCT. Read More

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Prognostic role of RDW in hematological malignancies: a systematic review and meta-analysis.

Cancer Cell Int 2018 23;18:61. Epub 2018 Apr 23.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: Red blood cell distribution width (RDW), a biomarker for discrimination of anemia, has been recently identified as a prognostic factor in various types of cancer. Here we performed a meta-analysis in order to assess the correlation between RDW and the survival outcomes in patients with hematologic malignances.

Patients/methods: We systematically searched PubMed, Embase, and ISI Web of Science for relevant studies, to investigate the prognostic significance of RDW in hematological malignancies. Read More

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Identification of four differentially methylated genes as prognostic signatures for stage I lung adenocarcinoma.

Cancer Cell Int 2018 19;18:60. Epub 2018 Apr 19.

Department of Medical Imaging, The Fourth People's Hospital of Huai'an, Huai'an, Jiangsu China.

Background: Lung adenocarcinoma (LUAD) is the main subtype of non-small cell lung cancer with a low survival prognosis. We aimed to generate a prognostic model for the postoperative recurrence of LUAD.

Methods: The methylated DNA data of LUAD patients were downloaded from the Cancer Genome Atlas (TCGA). Read More

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Long non-coding RNA MIAT promotes growth and metastasis of colorectal cancer cells through regulation of miR-132/Derlin-1 pathway.

Cancer Cell Int 2018 16;18:59. Epub 2018 Apr 16.

1Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: Recently, long non-coding RNA (lncRNA) MIAT has been demonstrated as an oncogenic gene in several types of cancer. However, the role and mechanism of MIAT in colorectal cancer (CRC) have not been investigated.

Methods: Real-time PCR was used to measure MIAT expression in CRC tissues and cells. Read More

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Targeted delivery of immuno-RNase may improve cancer therapy.

Cancer Cell Int 2018 16;18:58. Epub 2018 Apr 16.

2Department of Biomedicine, Regeneration Medicine Institute, College of Pharmacy, Jilin University, Changchun, 130021 China.

Background: Immunotoxins are typical therapeutic drugs that can target cancer cells. They exploit the affinity of specific monoclonal antibodies or ligands to cancer cells to deliver a conjugated protein toxin to target sites, thus, attacking the cancer cells.

Methods: The immuno-RNase, Onc-V3, showed the stability of Onc-V3 in the blood stream. Read More

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Epithelial to mesenchymal transition induces stem cell like phenotype in renal cell carcinoma cells.

Cancer Cell Int 2018 11;18:57. Epub 2018 Apr 11.

1Department of Biophysics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background: Metastatic dissemination of solid tumors is often initiated by reactivation of an embryonic development program, epithelial-to-mesenchymal-transition (EMT). EMT has been associated with acquiring invasiveness and resistance to conventional therapies. However, the precise role of EMT during renal cell carcinoma is still debatable and is under investigation. Read More

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Correction to: MicroRNA-214-3p inhibits proliferation and cell cycle progression by targeting MELK in hepatocellular carcinoma and correlates cancer prognosis.

Cancer Cell Int 2018 10;18:55. Epub 2018 Apr 10.

3Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515 Guangdong Province China.

[This corrects the article DOI: 10.1186/s12935-017-0471-1.]. Read More

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April 2018
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DNA methylation affects metastasis of renal cancer and is associated with TGF-β/RUNX3 inhibition.

Cancer Cell Int 2018 10;18:56. Epub 2018 Apr 10.

2Department of Urology, Central Hospital of Zibo, No. 54 Gongqingtuan West Road, Zhangdian District, Zibo, 255036 Shandong Province China.

Background: Renal cell carcinoma accounts for 2-3% of all cancers and metastasis increased the malignancy of renal cancer. However, the role of methylation in metastasis of renal cancer is poorly understood.

Methods: We performed targeted gene array to compare the differential expressions of methylation regulated genes in metastatic and primary renal cancer tissues. Read More

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April 2018
2 Reads

Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells.

Cancer Cell Int 2018 4;18:53. Epub 2018 Apr 4.

1School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021 People's Republic of China.

Background: Signal transducer and activator of transcription 3 (STAT3) is persistently activated in a wide variety of epithelial cancers. Aberrant activity of STAT3 correlates with tumor growth, invasion and metastasis, which makes it a potential therapeutic target of cancer. To explore the biological role of STAT3 in esophageal cancer, we used small hairpin RNA to knockdown the expression of the STAT3 gene in the esophageal carcinoma ECA109 cell line and the cell apoptosis, cell cycle and cell migration were investigated. Read More

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April 2018
3 Reads

MiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer.

Cancer Cell Int 2018 3;18:52. Epub 2018 Apr 3.

1Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West College Road, Wenzhou, 325027 Zhejiang China.

Objective: To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells.

Methods: Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-culture system. Read More

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April 2018
2 Reads

MiR-144-3p promotes the tumor growth and metastasis of papillary thyroid carcinoma by targeting paired box gene 8.

Cancer Cell Int 2018 4;18:54. Epub 2018 Apr 4.

1Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, 155 NanJing North Road, Shenyang, 110000 China.

Background: Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand the effect of MiR-144-3p in papillary thyroid carcinoma (PTC) as well as the associated mechanisms. Read More

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April 2018
1 Read

Tumor-suppressor role of miR-139-5p in endometrial cancer.

Cancer Cell Int 2018 2;18:51. Epub 2018 Apr 2.

1Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 Jiangsu China.

Background: Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Several study's show that miR-139-5p is involved in the tumorigenesis and metastasis of various cancers. Read More

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April 2018
2 Reads

A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer.

Cancer Cell Int 2018 2;18:50. Epub 2018 Apr 2.

Department of Oncology, Hongze District People's Hospital, 102 Dongfeng Road, Hongze District, Huai'an, 223100 Jiangsu China.

Background: Gastric cancer presents a major health burden worldwide. Therefore, many molecular targeting agents have been evaluated for treatment of gastric cancer. Gefitinib has shown anticancer activity against gastric cancer which work through inhibiting epidermal growth factor receptor (EGFR). Read More

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April 2018
1 Read

microRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1.

Cancer Cell Int 2018 2;18:49. Epub 2018 Apr 2.

3Department of Spinal Surgery, The Sixth Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830002 Xinjiang China.

Background: Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of miR-338-3p in OS cells.

Methods: qRT-qPCR was performed to quantify miR-338-3p expression levels in OS tissue samples and in three common OS cell lines. Read More

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April 2018
1 Read

Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells.

Cancer Cell Int 2018 27;18:48. Epub 2018 Mar 27.

Department of Colorectal Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092 China.

Background: Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates the Wnt signal transduction pathway. Recent studies have showed down-regulation of SFRP1 expression in colorectal cancer (CRC). We aimed to evaluate the effect of SFRP1 on the proliferation, migration, invasion and apoptosis of CRC cells in vitro. Read More

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March 2018
1 Read

Prognostic value of long non-coding RNA BLACAT1 in patients with papillary thyroid carcinoma.

Cancer Cell Int 2018 27;18:47. Epub 2018 Mar 27.

1Department of Endocrinology and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400043 China.

Background: Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients with papillary thyroid cancer (PTC) remain unknown.

Methods: The expression profile of BLACAT1 in 87 PTC patients (case group) and 36 patients with nodular goiter (control group) were investigated by qRT-PCR. Read More

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March 2018
3 Reads

Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.

Cancer Cell Int 2018 21;18:46. Epub 2018 Mar 21.

1Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000 Thailand.

Background: Abnormally high expression of the mammalian de novo lipogenesis (DNL) pathway in various cancer cells promotes cell over-proliferation and resistance to apoptosis. Inhibition of key enzymes in the DNL pathway, namely, ATP citrate lyase, acetyl-CoA carboxylase, and fatty acid synthase (FASN) can increase apoptosis without cytotoxicity to non-cancerous cells, leading to the search for and presentation of novel selective and powerful targets for cancer therapy. Previous studies reported that epistructured catechins, epigallocatechin gallate (EGCG) and epicatechin (EC) exhibit different mechanisms regarding a strong inducer of apoptosis in various cancer cell lines. Read More

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March 2018
1 Read

Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression.

Cancer Cell Int 2018 21;18:45. Epub 2018 Mar 21.

1Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, 410013 Hunan People's Republic of China.

Background: Abnormal expression of long non-coding RNA (lncRNAs) often facilitates unrestricted growth of cancer cells. Long intergenic non-protein coding RNA 1510, an enhancer lncRNA (LINC01510), a lncRNA enhancer is upregulated in colorectal cancer (CRC), and its expression might relate to MET as revealed by lncRNA microarray data. However, the potential biological role of LINC01510 and its regulatory mechanism in CRC remain unclear. Read More

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March 2018
11 Reads

Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight.

Cancer Cell Int 2018 20;18:44. Epub 2018 Mar 20.

Department of Biological-Sciences, Birla Institute of Technology and Sciences (BITS), Campus, VidyaVihar, Pilani, Rajasthan 333031 India.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection followed by adjuvant and systemic chemotherapy are the most meticulously followed treatment procedures but the complex etiology and high metastatic potential of the disease renders surgical treatment futile in majority of the cases. Another hindrance to the scenario is the acquired resistance to drugs resulting in relapse of the disease. Read More

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March 2018
1 Read

Alteration of metabolite profiling by cold atmospheric plasma treatment in human myeloma cells.

Cancer Cell Int 2018 20;18:42. Epub 2018 Mar 20.

1State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049 Shaanxi People's Republic of China.

Background: Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheric plasma is a rapidly developed technology in recent years, which has been widely applied in biomedicine. Although plasma could efficiently inactivate various tumor cells, the effects of plasma on tumor cell metabolism have not been studied yet. Read More

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March 2018
2 Reads

Transcription factor E2F3a regulates transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia.

Cancer Cell Int 2018 20;18:40. Epub 2018 Mar 20.

Hematology & Oncology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health; Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; National Key Discipline of Pediatrics, Ministry of Education, Beijing, China.

Background: Low expression of and caspase 8 associated protein 2 () are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL).

Methods: Dual-luciferase reporter assay and wild type as well as four mutated types of reporter plasmids were used to demonstrate the activation of E2F3a on transcription. The direct binding of E2F3a with the promoter of was shown by Chromatin Immunoprecipitation (ChIP). Read More

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March 2018
3 Reads

Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma.

Cancer Cell Int 2018 20;18:39. Epub 2018 Mar 20.

Department of Radiation Oncology, School of Medicine, Sichuan Cancer Hospital & Institute, and Sichuan Cancer Center, University of Electronic Science and Technology of China, No. 55, 4th Section of Renmin South Road, Chengdu, 610041 Sichuan China.

Background: MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ESCC, especially in its effects on radiation-sensitivity of ESCC.

Methods: Expression of miR-21 was detected in 63 pairs ESCC tumor and adjacent non-tumoral tissues using qRT-PCR, correlation between miR-21 and clinicopathological feature of ESCC was analyzed. Read More

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March 2018
2 Reads

The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma.

Cancer Cell Int 2018 16;18:38. Epub 2018 Mar 16.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu China.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in China. Considering the poor prognosis of ESCC, the aim of this study is to dissect the effects of long non-coding RNA (lncRNA) AK001796 on cell proliferation and cell cycle in vitro and tumorigenicity in vivo, providing therapeutic targets for ESCC.

Methods: We conducted quantitative real time PCR to detect the expression level of lncRNA AK001796 in human ESCC tumor and adjacent non-tumor tissues, and analyzed the correlation between lncRNA AK001796 expression and clinicopathologic feature of ESCC patients. Read More

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March 2018
2 Reads

MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing's sarcoma cells.

Cancer Cell Int 2018 12;18:37. Epub 2018 Mar 12.

Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5593 Japan.

Background: MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. Here, we show that miRNAs play an important function in the down-regulation of FAS expression in Ewing's sarcoma (ES) cells.

Methods: To identify and characterize possible oncogenic factors in ES, we employed a microarray-based approach to profile the changes in the expression of miRNAs and their target mRNAs in five ES cell lines and human mesenchymal stem cells (hMSCs). Read More

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March 2018
1 Read

Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D.

Cancer Cell Int 2018 20;18:43. Epub 2018 Mar 20.

2Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 USA.

Background: Three-dimensional cultures of mammary epithelial cells allow for biologically-relevant studies of the development of the mammary gland in rodents and humans under normal and pathological conditions, like carcinogenesis. Under these conditions, mammotropic hormones play significant roles in tissue morphogenesis. Therefore, a system that recreates the normal, hormonally responsive epithelium would be a valuable tool to study the normal state and its transition to carcinogenesis. Read More

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March 2018
1 Read

LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells.

Cancer Cell Int 2018 20;18:41. Epub 2018 Mar 20.

Department of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.

Background: The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of bladder cancer cells and the epithelial-to-mesenchymal transition (EMT). LncRNA X inactive specific transcript (XIST) is highly expressed in tumour tissues, promotes cancer progression and might act as an miRNA molecular sponge. Read More

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March 2018
1 Read

Targeting FBPase is an emerging novel approach for cancer therapy.

Cancer Cell Int 2018 9;18:36. Epub 2018 Mar 9.

Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 38 Huangtang Road, Meizhou, 514000 China.

Cancer is a leading cause of death in both developed and developing countries. Metabolic reprogramming is an emerging hallmark of cancer. Glucose homeostasis is reciprocally controlled by the catabolic glycolysis and anabolic gluconeogenesis pathways. Read More

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March 2018
1 Read

Prognostic role of long non-coding RNA XIST expression in patients with solid tumors: a meta-analysis.

Cancer Cell Int 2018 9;18:34. Epub 2018 Mar 9.

1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and Treatment Associated with High Technology Research, The Third Affiliated Hospital of Soochow University, Changzhou, 213003 China.

Background: The aberrant expression of long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been demonstrated to be involved in the tumourigenesis and the development of various cancers. Therefore, we conducted a meta-analysis to assess the prognostic role of lncRNA XIST expression in solid tumors.

Methods: The databases of PubMed, EMBase, Web of Science, Cochrane library (up to Dec 31, 2017) were searched for the related studies and identified 15 eligible studies containing 1209 patients to include in the meta-analysis. Read More

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March 2018
2 Reads

Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1.

Cancer Cell Int 2018 9;18:35. Epub 2018 Mar 9.

Department of Medical Oncology, the First Affiliated Hospital, Zhengzhou University, 1 East Jianshe Road, Zhengzhou, 450052 Henan People's Republic of China.

Background: Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with MYO5B and plays an important role in regulating plasma membrane recycling. However, little is known about the clinical significance of DUSP2 in colorectal cancer (CRC).

Methods: In this study, we investigated Rab11-FIP2 expression by immunohistochemistry in 125 patients with colorectal cancer. Read More

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March 2018
1 Read

Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma.

Cancer Cell Int 2018 5;18:31. Epub 2018 Mar 5.

Department of Urology, Minimally Invasive Surgery Center, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road 1#, Haizhu District, Guangzhou, 510230 Guangdong China.

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and is frequently accompanied by the genetic features of von Hippel-Lindau (VHL) loss. VHL loss increases the expression of hypoxia-inducible factors (HIFs) and their targets, including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF). The primary treatment for metastatic RCC (mRCC) is molecular-targeted therapy, especially anti-angiogenic therapy. Read More

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March 2018
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Differential mRNA expression of the main apoptotic proteins in normal and malignant cells and its relation to in vitro resistance.

Cancer Cell Int 2018 5;18:33. Epub 2018 Mar 5.

1Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin (JFM), Comenius University in Bratislava (CU), Mala Hora 4D, 03601 Martin, Slovak Republic.

Background: Apoptosis plays an important role in the development and homeostasis of multicellular organisms and its deregulation may result in many serious diseases, including cancer. Now it is clear that some oncogenic mutations disrupt apoptosis, leading to tumour initiation, progression or metastasis. Here, expression of apoptotic genes in context of drug resistance was investigated. Read More

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March 2018
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Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer.

Cancer Cell Int 2018 5;18:32. Epub 2018 Mar 5.

3Department of Surgery, Ewha Womans University College of Medicine, Seoul, South Korea.

Background: Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5'-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study examined the effects of epidermal growth factor (EGF) and Rab25 on integrin β1 localization in colon cancer cells.

Methods: HCT116 human colon cancer cells were treated with increasing concentrations of EGF, and cell proliferation and protein expression were monitored by MTT and western blot analyses, respectively. Read More

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March 2018
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Arachidonic acid-induced Ca entry and migration in a neuroendocrine cancer cell line.

Cancer Cell Int 2018 2;18:30. Epub 2018 Mar 2.

Department of Neurosciences, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH 43614-2598 USA.

Background: Store-operated Ca entry (SOCE) has been implicated in the migration of some cancer cell lines. The canonical SOCE is defined as the Ca entry that occurs in response to near-maximal depletion of Ca within the endoplasmic reticulum. Alternatively, arachidonic acid (AA) has been shown to induce Ca entry in a store-independent manner through Orai1/Orai3 hetero-multimeric channels. Read More

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March 2018
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