1,867 results match your criteria Cancer Biother. Radiopharm.[Journal]


Loadability and Releasing Profiles and Pharmacokinetics of Vinorelbine and Raltitrexed by CalliSpheres Beads.

Cancer Biother Radiopharm 2020 Jul 2. Epub 2020 Jul 2.

Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, China.

This study aimed to investigate the loadability and releasing profiles of vinorelbine and raltitrexed by CalliSpheres Beads (CB) , and further explored the pharmacokinetic features of vinorelbine and raltitrexed eluting CB Ten milligrams vinorelbine and 0.2 mg raltitrexed were mixed with 0.15 g CB at two sizes (100-300 and 300-500 μm) for 24 h, respectively, to measure the loadability. Read More

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http://dx.doi.org/10.1089/cbr.2019.3360DOI Listing

Long Noncoding RNA Regulator of Reprogramming Regulates Cell Growth, Metastasis, and Cisplatin Resistance in Gastric Cancer via Axis.

Cancer Biother Radiopharm 2020 Jul 2. Epub 2020 Jul 2.

Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China.

Gastric cancer (GC) is a common tumor found worldwide, and cisplatin is the first-line agent for the treatment of GC. However, the resistance to cisplatin is an obstacle. Here, we aim to explore the biological mechanism of long noncoding RNA regulator of reprogramming (ROR) in the cisplatin resistance of GC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3525DOI Listing

Circular RNA La-Related Protein 4 Inhibits Nonsmall Cell Lung Cancer Cell Proliferation While Promotes Apoptosis Through Sponging microRNA-21-5p.

Cancer Biother Radiopharm 2020 Jul 2. Epub 2020 Jul 2.

Department of Respiratory Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

This study aimed to investigate the function of circular RNA La-related protein 4 (circ-LARP4) on nonsmall cell lung cancer (NSCLC) progression. Circ-LARP4 overexpression and circ-LARP4 short hairpin RNA (shRNA) plasmids were transfected into NCI-H1650 cells and NCI-H1299 cells respectively. In rescue experiment, microRNA (miR)-21-5p overexpression and miR-21-5p shRNA plasmids were transfected into circ-LARP4 overexpression-treated NCI-H1650 cells and circ-LARP4 knockdown-treated NCI-H1650 cells, respectively. Read More

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http://dx.doi.org/10.1089/cbr.2020.3707DOI Listing

Downregulation of miR-125b-5p and Its Prospective Molecular Mechanism in Lung Squamous Cell Carcinoma.

Cancer Biother Radiopharm 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

To explore the clinical significance of miR-125b-5p and its potential mechanisms in lung squamous cell carcinoma (LUSC). An integrated analysis of data from in-house quantitative real-time polymerase chain reaction (qRT-PCR), microRNA-sequencing, and microarray assays to appraise the expression level of miR-125b-5p in LUSC tissues compared to adjacent noncancerous controls. The authors identified the candidate targets of miR-125b-5p and conducted functional analysis using computational biology strategies from gene ontology, the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, disease ontology (DO), and protein-protein interaction (PPI) network analyses to investigate the prospective mechanisms. Read More

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http://dx.doi.org/10.1089/cbr.2020.3657DOI Listing

Peripheral Blood Leukocytes and Platelets Serve as Prognostic Factors in Breast Cancer.

Cancer Biother Radiopharm 2020 Jun 29. Epub 2020 Jun 29.

Department of Thyroid and Breast Surgery, The First People's Hospital of Yunnan Province (the Affiliated Kunhua Hospital of Kunming University of Science and Technology), Kunming, China.

Tumor-infiltrating lymphocytes have been reported to be associated with response to neoadjuvant chemotherapy and survival in breast cancer (BC) patients. However, little is known about the value of peripheral blood parameter in predicting the prognosis in BC. In this study, parameters of complete blood count from 417 BC patients with a median 7. Read More

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http://dx.doi.org/10.1089/cbr.2019.3032DOI Listing

LncRNA ELF3-AS1 Promotes Nonsmall Cell Lung Cancer Cell Invasion and Migration by Downregulating miR-212.

Cancer Biother Radiopharm 2020 Jun 27. Epub 2020 Jun 27.

Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.

LncRNA ELF3-AS1 has been characterized as an oncogenic lncRNA in bladder cancer and oral cancer, whereas its role in nonsmall cell lung cancer (NSCLC) is unknown. In this study, the authors observed that ELF3-AS1 was upregulated in NSCLC tissues in comparison with that in paired nontumor tissues collected from 68 NSCLC patients. High expression levels of ELF3-AS1 predicted the poor survival of NSCLC patients. Read More

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http://dx.doi.org/10.1089/cbr.2019.3506DOI Listing

Naringenin Inhibits Cell Migration, Invasion, and Tumor Growth by Regulating circFOXM1/miR-3619-5p/SPAG5 Axis in Lung Cancer.

Cancer Biother Radiopharm 2020 Jun 27. Epub 2020 Jun 27.

Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Naringenin has been reported to play an anticancer role by inhibiting the metastasis of tumor cells, but the roles of naringenin and the molecular mechanisms mediated by it in lung cancer remain to be elucidated. Cell migration and invasion were determined by transwell assay. The expression levels of circular RNA FOXM1 (circFOXM1), microRNA-3619-5p (miR-3619-5p), and sperm-associated antigen 5 (SPAG5) in lung cancer were measured by quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1089/cbr.2019.3520DOI Listing

Identification of Key Biological Processes, Pathways, Networks, and Genes with Potential Prognostic Values in Hepatocellular Carcinoma Using a Bioinformatics Approach.

Cancer Biother Radiopharm 2020 Jun 26. Epub 2020 Jun 26.

Department of Anesthesiology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hepatocellular carcinoma (HCC), as one primary liver cancer type, accounts for 75%-85% of liver cancer cases. HCC is the second leading cause of cancer death in East Asia and sub-Saharan Africa and the sixth most common in western countries. Identification of key genes would facilitate the development of therapies and improve the prognosis outcomes of HCC patients. Read More

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http://dx.doi.org/10.1089/cbr.2019.3327DOI Listing

circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/ Axis.

Cancer Biother Radiopharm 2020 Jun 27. Epub 2020 Jun 27.

Department of Operation Room, Affiliated to Qingdao University Yuhuangding Hospital of Yantai, Shandong, China.

Acquired multidrug resistance is often blamed for the failure of chemotherapy in patients with malignant tumors, including chronic myeloid leukemia (CML). In this study, the authors investigated the role of circular RNA 0080145 (circ_0080145) in imatinib (IM) resistance of CML. Quantitative real-time polymerase chain reaction was applied to measure the expression of circ_0080145, microRNA-326 (miR-326), and PTPRF interacting protein alpha 1 () mRNA. Read More

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http://dx.doi.org/10.1089/cbr.2020.3600DOI Listing

LncRNA Promotes Hepatocellular Carcinoma Migration and Invasion Via Targeting miR-137/AKT2 Axis.

Cancer Biother Radiopharm 2020 Jun 24. Epub 2020 Jun 24.

Department of Interventional Medicine, The Second People's Hospital of Huaihua, Huaihua, China.

The current study aimed to investigate the effects of on the migration and invasion of hepatoma cells. The expressions of , miR-137, and were detected in hepatoma tissues and cells by performing quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The correlations among , miR-137, and were predicted by bioinformatics analysis and confirmed by dual-luciferase reporter assay, and Pearson test was performed to analyze their relevance. Read More

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http://dx.doi.org/10.1089/cbr.2019.3297DOI Listing

Analysis of the Role and Regulatory Mechanism of in Cervical Cancer Based on The Cancer Genome Atlas Database.

Cancer Biother Radiopharm 2020 Jun 23. Epub 2020 Jun 23.

Department of Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, People's Republic of China.

This study aimed to investigate the expression and clinical value of in cervical cancer and its possible mechanism of regulating the progress of cervical cancer. The expression of microRNAs (miRNAs) in cervical cancer was analyzed on The Cancer Genome Atlas (TCGA) database. The correlation between differentially expressed miRNAs and overall survival (OS) of cervical cancer patients was analyzed by Kaplan-Meier method. Read More

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http://dx.doi.org/10.1089/cbr.2020.3798DOI Listing

Prostate-Specific Membrane Antigen-Targeted Radiopharmaceuticals in Diagnosis and Therapy of Prostate Cancer: Current Status and Future Perspectives.

Cancer Biother Radiopharm 2020 Jun 23. Epub 2020 Jun 23.

Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Prostate cancer is the most common cancer to affect men in the United States and the second most common cancer in men worldwide. Prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET) imaging has become increasingly popular as a novel molecular imaging technique capable of improving the clinical management of patients with prostate cancer. To date, several Ga and F-labeled PSMA-targeted molecules have shown promising results in imaging patients with recurrent prostate cancer using PET/computed tomography (PET/CT). Read More

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http://dx.doi.org/10.1089/cbr.2020.3603DOI Listing

Circ_0074027 Contributes to Nonsmall Cell Lung Cancer Progression by Upregulating Expression Through miR-335-5p.

Cancer Biother Radiopharm 2020 Jun 22. Epub 2020 Jun 22.

Department of Pathology, Beilun District People's Hospital, Ningbo, China.

Circular RNAs (circRNAs) are crucial regulators in human cancers, including nonsmall cell lung cancer (NSCLC). In this study, we aim to explore the biological functions and molecular mechanisms of circ_0074027 in NSCLC. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine the expression of circ_0074027, paired like homeodomain 1 () mRNA, microRNA-335-5p (miR-335-5p), and cullin 4B () mRNA. Read More

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http://dx.doi.org/10.1089/cbr.2020.3579DOI Listing

Targeted Alpha Therapy: Current Clinical Applications.

Cancer Biother Radiopharm 2020 Jun 16. Epub 2020 Jun 16.

The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, United Kingdom.

α-Emitting radionuclides have been approved for cancer treatment since 2013, with increasing degrees of success. Despite this clinical utility, little is known regarding the mechanisms of action of α particles in this setting, and accurate assessments of the dosimetry underpinning their effectiveness are lacking. However, targeted alpha therapy (TAT) is gaining more attention as new targets, synthetic chemistry approaches, and α particle emitters are identified, constructed, developed, and realized. Read More

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http://dx.doi.org/10.1089/cbr.2020.3576DOI Listing

Restrains Apatinib Resistance in Human Gastric Cancer Cells Via Downregulating .

Cancer Biother Radiopharm 2020 Jun 16. Epub 2020 Jun 16.

Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of People's Liberation Army, Lanzhou, China.

Repeated administration has resulted in serious drug resistance in gastric cancer (GC). Previous studies showed that had a low expression in GC, and homeobox gene C10 (), a carcinogenic gene, was highly expressed in GC, while the molecular mechanism of involved in apatinib resistance in GC cells is still unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of and in GC tissues or cell lines. Read More

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http://dx.doi.org/10.1089/cbr.2019.3107DOI Listing

Iodine-125 Brachytherapy Can Prolong Progression-Free Survival of Patients with Locoregional Recurrence and/or Residual Hepatocellular Carcinoma After Radiofrequency Ablation.

Cancer Biother Radiopharm 2020 Jun 16. Epub 2020 Jun 16.

Department of Radiology, Lishui Central Hospital/Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Lishui, China.

Radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC) is limited by locoregional recurrence and/or residual tumors caused by incomplete ablation. Iodine-125 brachytherapy can achieve a high local control rate in solid carcinoma, but few studies have assessed the efficacy of this treatment for locoregional recurrence and/or residual HCC after RFA. To investigate the effectiveness and safety of iodine-125 brachytherapy for treating locoregional recurrence and/or residual HCC in patients treated with RFA. Read More

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http://dx.doi.org/10.1089/cbr.2020.3647DOI Listing

Synergism Between Immunotherapy and Radiotherapy in Esophageal Cancer: An Overview of Current Knowledge and Future Perspectives.

Cancer Biother Radiopharm 2020 Jun 16. Epub 2020 Jun 16.

Nuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, Italy.

Esophageal cancer (EC) is an aggressive neoplasm of the gastrointestinal tract that is usually treated with a combination of chemotherapy, radiotherapy (RT), and/or surgery, according to disease status. Despite the availability of multimodal therapeutic strategies, local recurrence is frequently observed. Immunotherapy is a promising therapeutic approach that is currently highly investigated in association to standard therapies, including RT, with the aim to improve patients' outcomes. Read More

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http://dx.doi.org/10.1089/cbr.2020.3643DOI Listing

Metformin Affects Paclitaxel Sensitivity of Ovarian Cancer Cells Through Autophagy Mediated by Long Noncoding RNASNHG7/miR-3127-5p Axis.

Cancer Biother Radiopharm 2020 Jun 9. Epub 2020 Jun 9.

Department of Breast and Thyroid Surgery, Tengzhou Central People's Hospital, Tengzhou, China.

Ovarian cancer is the public health issue worldwide. Paclitaxel is a first-line chemotherapy drug for ovarian cancer, but the paclitaxel resistance weakens the therapeutic effect. Metformin (Met) improved the paclitaxel sensitivity in a mouse model of ovarian cancer. Read More

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http://dx.doi.org/10.1089/cbr.2019.3390DOI Listing

Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p.

Cancer Biother Radiopharm 2020 Jun 9. Epub 2020 Jun 9.

Department of General Surgery I, Guiyang Hospital of Guizhou Aviation Industry Group, Guiyang, China.

Breast cancer (BC) is a common tumor in women worldwide, and irradiation (IR) resistance is a major obstacle for BC therapy. Circle RNAs (circRNAs) were identified to be implicated in the progression of cancer and IR resistance. However, the role of circABCB10 in BC progression and IR resistance is not well defined. Read More

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http://dx.doi.org/10.1089/cbr.2019.3389DOI Listing

LncRNA CTBP1-AS2 Promotes Cell Proliferation in Hepatocellular Carcinoma by Regulating miR-623/Cyclin D1 Axis.

Cancer Biother Radiopharm 2020 Jun 9. Epub 2020 Jun 9.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai, China.

This study aimed to investigate the role of lncRNA CTBP1-AS2 in hepatocellular carcinoma (HCC). The authors found that CTBP1-AS2 was upregulated in HCC by analyzing TCGA dataset. The downregulation of CTBP1-AS2 in HCC was confirmed by measuring the expression level of CTBP1-AS2 in both HCC and nontumor tissues from HCC patients. Read More

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http://dx.doi.org/10.1089/cbr.2019.3375DOI Listing

Targeted α-Therapy.

Cancer Biother Radiopharm 2020 Jun 5. Epub 2020 Jun 5.

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http://dx.doi.org/10.1089/cbr.2020.29008.mbrDOI Listing

The Evaluation of tLyP-1-Bound Killing Activity on a Liver Tumor Cell Line.

Cancer Biother Radiopharm 2020 Jun 3. Epub 2020 Jun 3.

Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.

The melanoma differentiation-associated gene-7 (Mda-7)/interleukin-24 (IL-24) is a tumor killing cytokine, the bystander effect of which can be enhanced through tethering to tumor homing peptides (THPs). After fusing tLyP-1, RGR, and buforin as THPs to , enzyme-linked immunosorbent assay (ELISA) was used to determine the secretion potency of the recombinant proteins. The killing potency of plasmids expressing IL-24, IL-24. Read More

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http://dx.doi.org/10.1089/cbr.2019.3080DOI Listing
June 2020
1.381 Impact Factor

Extract of L. Inhibits the Progression of Hepatocellular Carcinoma by Regulating and Pathway.

Cancer Biother Radiopharm 2020 Jun 2. Epub 2020 Jun 2.

Traditional Chinese Medicine, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.

Hepatocellular carcinoma (HCC) poses a growing threat to humans due to poor prognosis. Extract of L. (ESC) is reported to inhibit metastasis of HCC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3229DOI Listing

Feasibility of Thorium-227/Radium-223 Gamma-Camera Imaging During Radionuclide Therapy.

Cancer Biother Radiopharm 2020 Jun 2. Epub 2020 Jun 2.

Department of Radiation Physics, Skåne University Hospital, Lund, Sweden.

Thorium-227 (Th) is a long-lived (T = 18.7 d) α-emitter that has emerged as candidate for radioimmunotherapy. Imaging of patients treated with thorium-227 conjugates is challenging due to the low activity administered and to photon emissions with low yields. Read More

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http://dx.doi.org/10.1089/cbr.2019.3516DOI Listing

-215 Regulates the Apoptosis of HCT116 Colon Cancer Cells by Inhibiting X-Linked Inhibitor of Apoptosis Protein.

Cancer Biother Radiopharm 2020 May 28. Epub 2020 May 28.

Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, P.R. China.

X-linked inhibitor of apoptosis protein (XIAP) is the strongest member of the family of inhibitor of apoptosis protein. Studies found that the expression of XIAP in colon cancer tissue was significantly higher than that in adjacent tissues. Some studies also showed that the expression of -215 (miR-215) was significantly lower than that of the adjacent tissues. Read More

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http://dx.doi.org/10.1089/cbr.2019.3011DOI Listing

lncRNA IGF2-AS Promotes Cell Proliferation, Migration, and Invasion of Gastric Cancer by Modulating miR-937/EZH2 Axis.

Cancer Biother Radiopharm 2020 May 25. Epub 2020 May 25.

Department of Clinical Lab, The Zhuhai Hospital of Guangdong Province Traditional Chinese Medical Hospital, Zhuhai, Guangdong, China.

Gastric cancer (GC) is one of most common malignancies worldwide. Long noncoding RNA insulin growth factor 2 antisense (IGF2-AS) is associated with the progression of various cancers. Here, we further explore the detailed molecular mechanism of IGF2-AS in GC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3275DOI Listing
May 2020
1.381 Impact Factor

Knockdown SNHG20 Suppresses Nonsmall Cell Lung Cancer Development by Repressing Proliferation, Migration and Invasion, and Inducing Apoptosis by Regulating miR-2467-3p/E2F3.

Cancer Biother Radiopharm 2020 May 25. Epub 2020 May 25.

Department of Thoracic Surgery, The First People's Hospital of Guiyang, Guiyang, China.

Lung cancer was one of the most common malignant tumors around the world. In China, lung cancer has become the leading reason of malignant tumors-related mortality in urban population, whereas nonsmall cell lung cancer (NSCLC) occupied at least 80% of all lung cancers with poor 5-year survival rate. It had been reported that long noncoding RNA (lncRNA) small nucleolar RNA host gene 20 (SNHG20) was associated with NSCLC, but the regulatory mechanisms of SNHG20 in NSCLC needed further investigation. Read More

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http://dx.doi.org/10.1089/cbr.2019.3430DOI Listing

Examination of the Association Between 3,4-Divanillyltetrahydrofuran Lignan ( Origin) and Prostate Cancer Cells by I Radiolabeling.

Cancer Biother Radiopharm 2020 May 21. Epub 2020 May 21.

Institute of Nuclear Sciences, Ege University, Izmir, Turkey.

Prostate cancer is the most common type of cancer for men in many countries. One of the various prostate cancer therapy methods is hormone therapy, and explaining the association between androgen hormones and prostate cancer is a critical role for successful prostate cancer treatment. In the current study, the behavior of 3,4- divanillyltetrahydrofuran (DTH) was examined against prostate cancer cells, which have androgen sensitivity differences [LNCaP (+), PC3 (-)]. Read More

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http://dx.doi.org/10.1089/cbr.2020.3602DOI Listing

Quantitative Dual-Isotope Planar Imaging of Thorium-227 and Radium-223 Using Defined Energy Windows.

Cancer Biother Radiopharm 2020 May 19. Epub 2020 May 19.

Physics Department, Royal Marsden NHS Hospital, Sutton, United Kingdom.

Thorium-227 is an alpha-emitting radioisotope with potential therapeutic applications in targeted alpha therapy. Thorium-227 decays to Radium-223, which may have an independent biodistribution to that of the parent Thorium-227 radiopharmaceutical. Quantitative imaging with sodium iodide (NaI) detectors is challenging due to cross-talk between neighboring gamma photopeaks as well as scattered gamma photons. Read More

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http://dx.doi.org/10.1089/cbr.2019.3554DOI Listing

LINC01123 Promotes Progression of Colorectal Cancer via miR-625-5p/LASP1 Axis.

Cancer Biother Radiopharm 2020 May 18. Epub 2020 May 18.

Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Evidence from previous investigations points to a rising trend in the incidence of colorectal cancer (CRC) worldwide. The mortality resulting from this cancer is high. Unlike nonsmall cell lung cancer for which LINC01123 has been investigated, there are few reports on how this long noncoding RNA (lncRNA) regulates CRC. Read More

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http://dx.doi.org/10.1089/cbr.2020.3740DOI Listing

LncRNA-KAT7 Negatively Regulates miR-10a Through Epigenetic Pathway to Participate in Nonsmall Cell Lung Cancer.

Cancer Biother Radiopharm 2020 May 18. Epub 2020 May 18.

Department of Respiratory Medicine, Affiliated Heping Hospital of Changzhi Medical College, Changzhi City, P.R. China.

LncRNA-KAT7 is a recently identified tumor suppressor in colorectal cancer, whereas its roles in other malignancies remain unclear. This study aimed to investigate the roles of KAT7 nonsmall cell lung cancer (NSCLC). The results showed that KAT7 was downregulated in NSCLC and predicted poor survival. Read More

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http://dx.doi.org/10.1089/cbr.2019.3228DOI Listing

Long Noncoding RNA Facilitates Endometrial Cancer Development by Regulating and Gene Expressions.

Cancer Biother Radiopharm 2020 May 15. Epub 2020 May 15.

Department of Obstetrics and Gynecology, Xuzhou Central Hospital, Xuzhou, China.

Long noncoding RNA urothelial carcinoma associated 1 () was found to facilitate endometrial cancer cell metastasis, and high expression predicted endometrial cancer development and patients' worsened outcomes. This research aimed to investigate the cancer promoting role and mechanism of in endometrial cancer. Around 64 endometrioid adenocarcinoma patients' tissue specimens were analyzed by qRT-PCR. Read More

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http://dx.doi.org/10.1089/cbr.2019.3278DOI Listing
May 2020
1.381 Impact Factor

High Expression of Asparagine Synthetase Is Associated with Poor Prognosis of Breast Cancer in Chinese Population.

Cancer Biother Radiopharm 2020 May 15. Epub 2020 May 15.

Department of Thyroid Breast Surgery, Weihai Municipal Hospital, Weihai City, China.

This study aimed to determine the expression of asparagine synthetase () in breast cancer (BC) tissues and estimate its prognostic value for BC patients. Besides, the roles of in the proliferation of BC cells were also examined in the study. Quantitative real-time PCR was conducted to detect the expression of mRNA in BC tissues and normal controls. Read More

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http://dx.doi.org/10.1089/cbr.2019.3295DOI Listing

lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia.

Cancer Biother Radiopharm 2020 May 15. Epub 2020 May 15.

Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.

TP73-AS1 has been reported as an overexpressed oncogenic lncRNA in several types of cancer. However, these analyses of The Cancer Genome Atlas data set revealed downregulation of TP73-AS1 in acute myeloid leukemia (AML). In this study, we aimed to study the molecular mechanism between TP73-AS1 and cell proliferation in AML. Read More

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http://dx.doi.org/10.1089/cbr.2019.3142DOI Listing

LncRNA Promotes Bladder Cancer Occurrence Via Protecting from Downregulation by Sponging .

Cancer Biother Radiopharm 2020 Jun 15;35(5):319-328. Epub 2020 May 15.

Department of Urology, Nanjing Gaochun People's Hospital, Nanjing, China.

As a subtype of human genitourinary system cancer, the morbidity of bladder cancer (BC) continues to rise. Because of the high potentiality of cell metastasis, the 5-year survival rate of BC is relatively low. Long noncoding RNAs (lncRNAs) have been verified by a large body of literature to engage in the tumorigenesis of a few cancers. Read More

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http://dx.doi.org/10.1089/cbr.2019.3021DOI Listing

Sgc8-c Aptamer as a Potential Theranostic Agent for Hemato-Oncological Malignancies.

Cancer Biother Radiopharm 2020 May;35(4):262-270

Departamento de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.

Aptamers represent an emerging class of oligonucleotides that have the ability to bind ligands with high affinity. Sgc8-c aptamer recognizes PTK7, a member of the catalytically defective receptor protein tyrosine kinase family that is upregulated in various cancers, including hemato-oncological malignancies. Herein, an Sgc8-c-NOTA-radiolabeled probe was prepared for theranostic purpose. Read More

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http://dx.doi.org/10.1089/cbr.2019.3402DOI Listing

LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress the Proliferation of Colorectal Cancer Cells.

Cancer Biother Radiopharm 2020 May 14. Epub 2020 May 14.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang City, People's Republic of China.

A recent study reported the oncogenic function of lncRNA NR2F1-AS1 in liver cancer. Interestingly, by analyzing TCGA data set, the downregulation of NR2F1-AS1 in colorectal cancer (CRC) was observed. This observation triggered interest to analyze the functions of NR2F1-AS1 in CRC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3237DOI Listing

Long Noncoding RNA Plasmacytoma Variant Translocation 1 Regulates Cisplatin Resistance via miR-3619-5p/TBL1XR1 Axis in Gastric Cancer.

Cancer Biother Radiopharm 2020 May 14. Epub 2020 May 14.

Department of Oncology, Liaocheng Cancer Prevention and Treatment Hospital, Liaocheng, China.

Chemoresistance greatly hinders the treatment of gastric cancer (GC). Long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been corroborated to be involved in chemoresistance in diverse cancers, including GC. The authors' aim was to investigate the underlying molecular mechanism of PVT1 in cisplatin (DPP) resistance in GC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3342DOI Listing

Long Noncoding RNA SOX2-OT Knockdown Inhibits Proliferation and Metastasis of Prostate Cancer Cells Through Modulating miR-452-5p/HMGB3 Axis and Inactivating Wnt/β-Catenin Pathway.

Cancer Biother Radiopharm 2020 May 14. Epub 2020 May 14.

Department of Urology, Fudan University, Minhang Hospital, Shanghai, China.

Recent studies have proven that abnormal expression of long noncoding RNAs (lncRNAs) often contributes to growth and invasion of cancer cells. The purpose of this study was to investigate the biological function and regulatory mechanism of lncRNA SOX2 overlapping transcript (SOX2-OT) in prostate cancer (PCa) progression. The expression of SOX2-OT, microRNA-452-5p (miR-452-5p), and high mobility group box 3 (HMGB3) was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1089/cbr.2019.3479DOI Listing

CircSMARCA5 Facilitates the Progression of Prostate Cancer Through miR-432/PDCD10 Axis.

Cancer Biother Radiopharm 2020 May 14. Epub 2020 May 14.

Department of Urology Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Circular RNAs (circRNAs) have been reported to be implicated in the pathogenesis of prostate cancer (PCa). Herein, the authors intended to explore the role and the molecular mechanism of circRNA SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 5 (circSMARCA5) in PCa. The levels of circSMARCA5, SMARCA5, miR-432, and programmed cell death 10 (PDCD10) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1089/cbr.2019.3490DOI Listing

LncRNA HCP5 Regulates Pancreatic Cancer Progression by miR-140-5p/CDK8 Axis.

Cancer Biother Radiopharm 2020 May 14. Epub 2020 May 14.

Department of Hepatobiliary Surgery, Dongying City People's Hospital, Dongying, China.

Pancreatic cancer (PC) is a leading cause of cancer-related deaths worldwide. Human leukocyte antigen complex P5 (HCP5), a member of long noncoding RNAs (lncRNAs), was reported to be associated with the poor prognosis of PC. However, the mechanism of HCP5 in regulating the progression of PC remains poorly defined. Read More

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http://dx.doi.org/10.1089/cbr.2019.3294DOI Listing

Key Genes Associated with Prognosis and Tumor Infiltrating Immune Cells in Gastric Cancer Patients Identified by Cross-Database Analysis.

Cancer Biother Radiopharm 2020 May 13. Epub 2020 May 13.

The Second Clinical Medical College of Lanzhou University, Lanzhou, China.

The molecular mechanisms underlying gastric cancer (GC) progression are unclear. The authors examined key genes associated with the prognosis and tumor-infiltrating immune cells in patients with GC. Gene expression omnibus (GEO) was used to filter and obtain GC-related differentially expressed genes (DEGs). Read More

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http://dx.doi.org/10.1089/cbr.2019.3423DOI Listing

Downregulation of lncRNA LINC-PINT Participates in the Recurrence of Esophageal Squamous Cell Carcinoma Possibly by Interacting miRNA-21.

Cancer Biother Radiopharm 2020 May 13. Epub 2020 May 13.

Department of Thoracic surgery, Sichuan Cancer Hospital, Chengdu City, P.R. China.

LncRNA long intergenic non-protein coding RNA, p53 induced transcript (LINC-PINT) is downregulated in multiple types of cancer cells. The authors aimed to explore the possible involvement of LINC-PINT in esophageal squamous cell carcinoma (ESCC). Sixty-two patients with early-stage ESCC were included in this study. Read More

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http://dx.doi.org/10.1089/cbr.2019.3167DOI Listing
May 2020
1.381 Impact Factor

SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by Sequestering miR-9-5p to Upregulate CNNM1 Expression.

Cancer Biother Radiopharm 2020 May 12. Epub 2020 May 12.

Fourth Department of Hepatic Surgery, Second Military Medical University, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer-related deaths worldwide, has risen public concern. Data from previous work have validated that long noncoding RNAs are active participators in the malignant processes of a host of cancers. Small nucleolar RNA host gene 7 (SNHG7) has been revealed to act as a tumor promoter in several cancers and SNHG7 inhibition was revealed to suppress cell invasion in HCC. Read More

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http://dx.doi.org/10.1089/cbr.2019.2996DOI Listing

Circ_0000526 Blocks the Progression of Breast Cancer by Sponging miR-492.

Cancer Biother Radiopharm 2020 May 8. Epub 2020 May 8.

Department of Thyroid and Breast Surgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.

Breast cancer is one of the leading causes of cancer-associated death. This work aimed to explore the expression, function, and mechanism of circ_0000526 on the progression of breast cancer. The expressions of circ_0000526, miR-492, and suppressor of cytokine signaling 2 () in breast cancer samples were measured using quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1089/cbr.2019.3513DOI Listing

Long Noncoding RNA Sponges to Facilitate Hepatocellular Carcinoma Progression Through Increasing .

Cancer Biother Radiopharm 2020 May 8. Epub 2020 May 8.

Department of Radiology and Xiangya Hospital, Central South University, Changsha, China.

Hepatocellular carcinoma (HCC) possesses high morbidity and mortality and has become the most frequently diagnosed liver cancer globally. Long noncoding RNAs have been widely studied because they exert essential functions in human diseases. The aim of the study is to explore the role and molecular regulatory mechanism of in HCC. Read More

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http://dx.doi.org/10.1089/cbr.2019.3271DOI Listing

Downregulation of NEAT1 Suppresses Cell Proliferation, Migration, and Invasion in NSCLC Via Sponging miR-153-3p.

Cancer Biother Radiopharm 2020 Jun 7;35(5):362-370. Epub 2020 May 7.

Department of Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to play a promotive role in nonsmall cell lung cancer (NSCLC) progression through microRNAs (miRNAs). However, the exact influence and mechanism of NEAT1 were unsatisfied. Quantitative real-time polymerase chain reaction was applied to examine the expression of NEAT1 and miR-153-3p. Read More

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http://dx.doi.org/10.1089/cbr.2019.3119DOI Listing

miR-205 Promotes Apoptosis of Cervical Cancer Cells and Enhances Drug Sensitivity of Cisplatin by Inhibiting YAP1.

Cancer Biother Radiopharm 2020 Jun 5;35(5):338-344. Epub 2020 May 5.

Department of Pharmacology, Qiqihar Medical University, Qiqihar, China.

Elevated expression of Yes-associated protein (YAP1) involves in the pathogenesis of cervical cancer. Bioinformatics analysis showed a targeting relationship between miR-205 and the 3'-UTR of YAP1. In this study, we aim to explore the role of miR-205 in the proliferation, apoptosis, or cisplatin (CDDP) resistance of cervical cancer cells. Read More

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http://dx.doi.org/10.1089/cbr.2019.2983DOI Listing
June 2020
1.381 Impact Factor

Suppresses Colorectal Cancer Development Through Regulating / Axis or / Axis.

Cancer Biother Radiopharm 2020 May 5. Epub 2020 May 5.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

It was reported that circular RNAs (circRNAs) exerted important function in various human cancers. However, the function of circFAT1 was less reported. The purpose of this study was to reveal the functional mechanism of circFAT1 in colorectal cancer (CRC). Read More

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http://dx.doi.org/10.1089/cbr.2019.3291DOI Listing
May 2020
1.381 Impact Factor

MEG3 Induces Cervical Carcinoma Cells' Apoptosis Through Endoplasmic Reticulum Stress by miR-7-5p/STC1 Axis.

Cancer Biother Radiopharm 2020 May 5. Epub 2020 May 5.

Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.

Many patients with advanced cervical cancer (CC) have a poor prognosis and their mortality rank the first among women with malignant tumors. It's essential to explore the molecular mechanism of CC in clinical practice. Long noncoding RNA maternally expressed gene 3 (MEG3) has been reported to downregulate in CC tissues. Read More

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http://dx.doi.org/10.1089/cbr.2019.3344DOI Listing