1,422 results match your criteria Cancer Biomarkers[Journal]


Nomogram based on pre-treatment inflammatory biomarkers predicting survival in patients with head and neck soft tissue sarcoma.

Cancer Biomark 2020 Jul 3. Epub 2020 Jul 3.

Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, Sichuan, China.

Background: Systemic inflammatory biomarkers reflect level of inflammatory response, which have been suggested as prognostic factors in cancer patients.

Objective: To estimate the prognostic value of inflammatory biomarkers in 149 patients with head and neck soft tissue sarcoma (HNSTS).

Methods: Pre-treatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), neutrophil-platelet score (NPS) and Aarhus Composite Biomarker Score (ACBS) were analyzed for association with overall survival (OS) and progression-free survival (PFS). Read More

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http://dx.doi.org/10.3233/CBM-201739DOI Listing

Serum interleukin-8 as a potential diagnostic biomarker in esophageal squamous cell carcinoma.

Cancer Biomark 2020 Jun 24. Epub 2020 Jun 24.

The Cancer Hospital of Shantou University Medical College, Guangdong, China.

Background: Esophageal squamous cell carcinoma (ESCC) has poor prognosis mainly due to the difficulty of making early diagnosis. Therefore, novel biomarkers are critically needed.

Objective: We aimed to investigate the diagnostic value of serum interleukin-8 (IL-8) in ESCC. Read More

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http://dx.doi.org/10.3233/CBM-201687DOI Listing

Long intergenic noncoding RNA LINC00173 as a potential serum biomarker for diagnosis of non-small-cell lung cancer.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Background: Long intergenic non-coding RNA (lincRNA) belongs to a special type of RNA that is unable to encode proteins but has been proved to play a role in gene regulation and differentially expressed in various malignant tumors.

Objective: In this study, we aimed to identify whether lincRNA LINC00173 was differentially expressed in non-small-cell lung cancer (NSCLC) and whether it could serve as a potential diagnostic biomarker.

Methods: The quantification real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression of LINC00173 in serum and cultured cells. Read More

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http://dx.doi.org/10.3233/CBM-201616DOI Listing

Screening and identification of key biomarkers in alimentary tract cancers: A bioinformatic analysis.

Cancer Biomark 2020 Jul 1. Epub 2020 Jul 1.

Center of Gastrointestinal disease, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.

Alimentary tract cancers (ATCs) are the most malignant cancers in the world. Numerous studies have revealed the tumorigenesis, diagnosis and treatment of ATCs, but many mechanisms remain to be explored. To identify the key genes of ATCs, microarray datasets of oesophageal cancer, gastric cancer and colorectal cancer were obtained from the Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.3233/CBM-201580DOI Listing

Homocysteine: A novel prognostic biomarker in liver transplantation for alpha-fetoprotein- negative hepatocellular carcinoma.

Cancer Biomark 2020 Jun 24. Epub 2020 Jun 24.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Precise recipient selection optimizes the prognosis of liver transplantation (LT) for hepatocellular carcinoma (HCC). Alpha-fetoprotein (AFP) is the most commonly used biomarker for diagnosis and prognosis of HCC in the clinical context. As a crucial molecule in methionine cycle, homocysteine (Hcy) level has been proved to be related to HCC progression and metastasis. Read More

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http://dx.doi.org/10.3233/CBM-201545DOI Listing

miR-21-5p promotes lung adenocarcinoma cell proliferation, migration and invasion via targeting WWC2.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Objective: Studies have suggested that miR-21-5p and WWC2 are key players in most cancer types, yet the underlying mechanisms in lung adenocarcinoma (LUAD) remain elusive. This study made in-depth research on the two factors-dependent mechanisms underlying LUAD occurrence and development.

Methods: Bioinformatics methods were employed to identify the miRNA and its target gene of interest. Read More

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http://dx.doi.org/10.3233/CBM-201489DOI Listing

The clinical significance of Interleukin 24 and its potential molecular mechanism in laryngeal squamous cell carcinoma.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Research, Guangxi Medical University Cancer Hospital, Guangxi, China.

Interleukin 24 (IL24) has been documented to be highly expressed in several cancers, but its role in laryngeal squamous cell carcinoma (LSCC) remains unclarified. In this study, to reveal the function and its clinical significance of IL24 in LSCC, multiple detecting methods were used comprehensively. IL24 protein expression was remarkably higher in LSCC (n= 49) than non-cancerous laryngeal controls (n= 26) as detected by in-house immunohistochemistry. Read More

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http://dx.doi.org/10.3233/CBM-201441DOI Listing

Identification of let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

Background: Among patients diagnosed with non-muscle invasive bladder cancer (NMIBC), 30% to 70% experience recurrences within 6 to 12 years of diagnosis. The need to screen for these events every 3 to 6 months and ultimately annually by cystoscopy makes bladder cancer one of the most expensive malignancies to manage.

Objective: The of this study was to identify reproducible prognostic microRNAs in resected non-muscle invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype as potential biomarkers and molecular therapeutic targets. Read More

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http://dx.doi.org/10.3233/CBM-191322DOI Listing

Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.

Cancer Biomark 2020 Jun 23. Epub 2020 Jun 23.

Background: Hepatocellular carcinoma (HCC) is the leading cause of mortality worldwide. In recent years, the incidence of HCC induced by NAFLD is growing rapidly.

Objective: To screen for new pathogenic genes and related pathways both in NAFLD and HCC, and to explore the pathogenesis of progression from NAFLD to HCC. Read More

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http://dx.doi.org/10.3233/CBM-190169DOI Listing

Modeling the time-related fluctuations of AFP and PIVKA-II serum levels in patients with cirrhosis undergoing surveillance for hepatocellular carcinoma.

Cancer Biomark 2020 Jul 3. Epub 2020 Jul 3.

Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, Pisa, Italy.

Background: The time-related variability of HCC biomarkers has not been investigated so far.

Objective: To assess the changes of alpha-fetoprotein (AFP) and protein induced by vitamin-K absence/antagonist-II (PIVKA-II) in patients with HCC (HCC+) as compared to patients without HCC (HCC-).

Methods: AFP and PIVKA-II were measured by a single laboratory using an automated chemiluminescent-enzyme-immunoassay (Fujirebio Inc. Read More

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http://dx.doi.org/10.3233/CBM-190118DOI Listing

Prognostic value of the systemic inflammation response index (SIRI) before and after surgery in operable breast cancer patients.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: The new systemic inflammation response index (SIRI) constructed based on neutrophil, monocyte and lymphocyte counts in peripheral blood is considered to be related to the prognosis of a variety of tumours.

Objective: To evaluate the prognostic value of the SIRI in operable breast cancer patients and establish a nomogram to predict the survival of breast cancer patients.

Methods: A total of 949 patients with operable breast cancer were enrolled in the present study. Read More

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http://dx.doi.org/10.3233/CBM-201682DOI Listing

Effects of PD-1/PD-L1 signaling pathway on intestinal flora in patients with colorectal cancer.

Cancer Biomark 2020 Jun 9. Epub 2020 Jun 9.

Department of Pathology, Dongguan Eastern Central Hospital, Dongguan, Guangdong, China.

Objective: To explore the effects of the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) signaling pathway on the intestinal flora in patients with colorectal cancer (CRC).

Methods: A total of 30 CRC patients treated with PD-1 monoclonal antibody therapy in the Oncology Department of our hospital from January 2018 to January 2019, and another 30 patients treated with routine non-immune therapy were enrolled. The feces specimens were collected for sequencing, the CRC model was established, and the 16S rRNA gene sequences in intestinal flora in feces specimens of mice were analyzed. Read More

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http://dx.doi.org/10.3233/CBM-201606DOI Listing

Thyroid hormones concentration in portal and peripheral blood in patients with pancreatic cancer: Preliminary study.

Cancer Biomark 2020 Jun 9. Epub 2020 Jun 9.

General and Transplant Surgery Department, Medical University of Lodz, Poland.

Background: The prognostic value of D-dimers concentration in portal blood in patients with pancreatic cancer has been established in several studies. Thyroid hormones and their receptors, especially T3 also seems to have a specific role in process of neoplasia and metastatic spread.

Objective: The aim of the study was to look for changes of thyroid hormones concentration between portal and peripheral blood. Read More

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http://dx.doi.org/10.3233/CBM-201595DOI Listing

MicroRNA-134 inhibits tumor stem cell migration and invasion in oral squamous cell carcinomas via downregulation of PI3K-Akt signaling pathway by inhibiting LAMC2 expression.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the mouth. Some studies have found that multiple microRNAs (miRs) participate in OSCC physiological and pathological processes.

Methods: We explored the mechanism of action of miR-134 in OSCC involving the PI3K-Akt signaling pathway. Read More

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http://dx.doi.org/10.3233/CBM-191362DOI Listing

FOXD1, negatively regulated by miR-186, promotes the proliferation, metastasis and radioresistance of nasopharyngeal carcinoma cells.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Background: Foxhead box D1 (FOXD1) is validated to be over-expressed in a variety of human malignancies and promotes cancer progression. Nevertheless, the role of FOXD1 and the associated mechanism in nasopharyngeal carcinoma (NPC) remain largely unknown.

Methods: A total of seventy-five cases of NPC tissue samples were collected. Read More

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http://dx.doi.org/10.3233/CBM-191311DOI Listing

Anti-Relapse effects of donor natural killer cells and IL-2 gene modification on allogeneic hematopoietic stem cell transplantation in acute leukemia.

Cancer Biomark 2020 Jun 19. Epub 2020 Jun 19.

Department of Vascular Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China.

Background: Patients with acute leukemia (AL) refractory to induction or reinduction chemotherapy show poor prognoses if they do not undergo allogeneic hematopoietic stem-cell transplantation (AHSCT). The present study aims to investigate whether donor natural killer (NK) cells and interleukin-2 (IL-2) gene modification exert anti-relapse effects on AHSCT after establishing a mouse model of AL.

Methods: C57BL/6 (H-2b) mice were selected as donor mice to obtain NK cells and hematopoietic stem cells, while BALB/c (H-2d) mice were selected as the recipient mice for AHSCT. Read More

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http://dx.doi.org/10.3233/CBM-191296DOI Listing

GR silencing impedes the progression of castration-resistant prostate cancer through the JAG1/NOTCH2 pathway via up-regulation of microRNA-143-3p.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Clinical Laboratory Medicine, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

Background: Despite notable progression from a therapeutic point of view, castration resistant prostate cancer (CRPC) remains a clinical significant stumbling block. The current study aimed to elucidate the functional role of the gene glucocorticoid receptor (GR) in CRPC, and identify the contributions of the GR gene in CRPC in connection with microRNA-143-3p (miR-143-3p)/Jagged1 (JAG1)/NOTCH2.

Methods: The expression of GR and miR-143-3p in CRPC tissues and cells as well as JAG1/NOTCH2 expression in CRPC tissues was initially determined by quantitative polymerase chain reaction and Western blot analyses. Read More

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http://dx.doi.org/10.3233/CBM-191271DOI Listing

CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.

Authors:
Jun Wu

Cancer Biomark 2020 Jun 19. Epub 2020 Jun 19.

Background: The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is the protein product of at least one splice variant of each gene contained a Marvel (MAL and related proteins for vesicle trafficking and membrane link) domain, involved in a variety of cellular processes and the pathogenesis of diseases, including tumorigenesis. However, the diverse expression patterns and prognostic values of eight CMTMs have yet to be elucidated.

Objective: We analyzed the expressions and impacts on survival of different CMTM factors in BC patients to determine their potential diagnosis and prognosis values in BC. Read More

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http://dx.doi.org/10.3233/CBM-191226DOI Listing

Application of proximity ligation assays to identify potential plasma biomarkers in oral cavity cancer patients: A case control study.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.

Background: Practical cancer biomarkers for oral cavity cancer are currently in limited use.

Objective: We aimed to investigate the differences in soluble E-cadherin between patients with oral cavity cancer and matched healthy participants via Proximity Ligation Assay (PLA).

Methods: Samples were taken from both patients diagnosed with oral cavity cancer, as well as non-cancerous participants. Read More

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http://dx.doi.org/10.3233/CBM-191195DOI Listing

miR-638 in circulating leukaemia cells as a non-invasive biomarker in diagnosis, treatment response and MRD surveillance of acute promyelocytic leukaemia.

Cancer Biomark 2020 Jun 19. Epub 2020 Jun 19.

Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: MicroRNA (miRNA) expression has been implicated in leukaemia. In recent years, miRNAs have been under investigation for their potential as non-invasive biomarkers in acute promyelocytic leukaemia (APL). We investigated whether miR-638 in circulating leukaemia cells is a non-invasive biomarker in diagnosis, assessment of the treatment response and minimal residual disease (MRD) surveillance of APL. Read More

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http://dx.doi.org/10.3233/CBM-190899DOI Listing

Up-regulation of circ_0000353 impedes the proliferation and metastasis of non-small cell lung cancer cells via adsorbing miR-411-5p and increasing forkhead box O1.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Affiliated to Tongji University, Shanghai, China.

Background: Non-small cell lung cancer (NSCLC) is the most common malignant tumor worldwide. This work focuses on investigating the role of circ_0000353 in NSCLC and its potential mechanism of action.

Methods: The expression levels of circ_0000353 and miR-411-5p in NSCLC and their matched normal lung tissues were detected by real-time PCR (RT-PCR). Read More

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http://dx.doi.org/10.3233/CBM-190812DOI Listing

Application of a non-invasive oral brushing procedure based on bisulfite sequencing of a 13-gene panel to study high-risk OSCC patients.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Biomedical and Neuromotor Sciences, Functional MR Unit, IRCCS Istituto Delle Scienze Neurologiche di Bologna, University of Bologna, Bologna, Italy.

Background: A non-invasive sampling procedure for the early detection of Oral Squamous Cell Carcinoma (OSCC) based on DNA methylation analysis of a panel of 13 genes was applied in 4 different OSCC risk-group of patients. Aim of the study is to evaluate the between-group differences and the variables related to the methylation profile of each group.

Methods: Oral brushing samples were collected from 54 healthy subjects, 31 Oral Leukoplakia (OL) patients, 18 Oral Lichen Planus (OLP) patients and 26 patients previously treated for OSCC. Read More

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http://dx.doi.org/10.3233/CBM-190422DOI Listing

Lipocalin-2: A novel diagnostic marker for hepatocellular carcinoma.

Cancer Biomark 2020 Jun 19. Epub 2020 Jun 19.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Viral hepatitis, alcoholism and non-alcoholic steatohepatitis are the most common risk factors. Despite the advances in HCC screening and treatment options, HCC still has a high mortality rate and a high rate of recurrence after treatment. Read More

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http://dx.doi.org/10.3233/CBM-190084DOI Listing

Long non-coding RNA MIR4435-1HG promotes cancer growth in clear cell renal cell carcinoma.

Authors:
Jianquan Ho

Cancer Biomark 2020 Jun 3. Epub 2020 Jun 3.

Background: Long non-coding RNAs (lncRNAs) play important roles in cancer development, yet their roles in renal carcinoma remain unclear.

Objective: We performed this study in order to investigate the expression and roles of lncRNAs in renal cell carcinoma.

Methods: In this study, we investigated the expression of lncRNAs in renal cell carcinoma through microarray analysis. Read More

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http://dx.doi.org/10.3233/CBM-201451DOI Listing

Long non-coding RNA LINC01116 regulated miR-744-5p/SCN1B axis to exacerbate lung squamous cell carcinoma.

Cancer Biomark 2020 Jun 5. Epub 2020 Jun 5.

TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Haerbin, Heilongjiang, China.

Background: Lung squamous cell carcinoma (LUSC) is a kind of lung cancer which possesses high morbidity and mortality. Long non-coding RNAs (lncRNAs) have been abundantly reported to participate in regulating cellular activities of various diseases, including cancers. LINC01116 was reported as a tumor promoter in some cancers, whereas its function has not been clarified in LUSC. Read More

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http://dx.doi.org/10.3233/CBM-190945DOI Listing

LncRNA SNHG8 induces ovarian carcinoma cells cellular process and stemness through Wnt/β-catenin pathway.

Cancer Biomark 2020 Jun 5. Epub 2020 Jun 5.

Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Ji'nan, Shandong, China.

Ovarian carcinoma ranks fifth in the leading causes of cancer-relevant deaths among the female, with the highest fatality rate in all gynecological malignant tumors and the rising incidence worldwide. Mounting evidence has unveiled that lncRNAs are implicated in the tumorigenesis and cancer development. Several studies have proven the carcinogenic role of SNHG8 in various malignancies, but the physiological functions of SNHG8 in ovarian carcinoma need more detailed explanations. Read More

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http://dx.doi.org/10.3233/CBM-190640DOI Listing

LncRNA-SARCC sensitizes osteosarcoma to cisplatin through the miR-143-mediated glycolysis inhibition by targeting Hexokinase 2.

Cancer Biomark 2020 ;28(2):231-246

Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Chemotherapy is one of the primary treatments used against cancer. Cisplatin is a conventional chemotherapy drug used to treat osteosarcoma; however, due to the development of cisplatin resistance, advantageous therapeutic outcomes and prognosis of osteosarcoma remain low. Thus, investigation of the specific targeted therapies to circumvent the anti-chemoresistance of osteosarcoma depends on understanding the molecular mechanisms underlying cisplatin resistance. Read More

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http://dx.doi.org/10.3233/CBM-191181DOI Listing
January 2020

Upregulation of microRNA-1303 is a potential prognostic marker of non-small cell lung cancer.

Cancer Biomark 2020 May 21. Epub 2020 May 21.

Department of Respiration, Liaocheng People's Hopsital, Liaocheng, Shandong, China.

Background: Non-small cell lung cancer (NSCLC) is the major subtype of lung cancer, imposing a huge disease burden worldwide. MicroRNA-1303 (miR-1303) has been demonstrated to be involved in several diseases, including cancers. In this study, we aimed to investigate the role of miR-1303 in NSCLC. Read More

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http://dx.doi.org/10.3233/CBM-201461DOI Listing

Anti-cervical cancer activity of secondary metabolites of endophytic fungi from Ginkgo biloba.

Cancer Biomark 2020 May 25. Epub 2020 May 25.

Shandong Key Laboratory in University of Functional Bioresource Utilization, College of Life Science, Dezhou University, Dezhou, Shandong, China.

Objectives: The purpose of this study was to isolate the secondary metabolites of endophytic fungi from Ginkgo biloba (SMEFGB) and investigate their anti-cervical cancer activity.

Methods: SMEFGB were cultured. The secondary metabolites of endophytic fungi was extracted, purified and identified. Read More

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http://dx.doi.org/10.3233/CBM-190462DOI Listing

Eight-gene signature predicts recurrence in lung adenocarcinoma.

Cancer Biomark 2020 May 22. Epub 2020 May 22.

Department of Cardiothoracic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Recurrence significantly influences the survival in lung patients with adenocarcinoma (LUAD). However, there are less gene signatures that predict recurrence risk of LUAD. We performed this study to construct a model to predict risk of recurrence in LUAD. Read More

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http://dx.doi.org/10.3233/CBM-190329DOI Listing

MiR-204-5p/TFAP2A feedback loop positively regulates the proliferation, migration, invasion and EMT process in cervical cancer.

Cancer Biomark 2020 May 21. Epub 2020 May 21.

MicroRNAs (MiRNAs) have been clarified as crucial regulators of the pathological processes in various carcinomas in the past years. Interestingly, existing evidence has manifested that microRNA-204-5p (miR-204-5p) is engaged in the initiation and progression of multiple carcinomas. However, the potential of miR-204-5p in cervical cancer remains to be disentombed. Read More

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http://dx.doi.org/10.3233/CBM-191064DOI Listing

Serum netrin-1 as a biomarker for colorectal cancer detection.

Cancer Biomark 2020 May 21. Epub 2020 May 21.

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Recent evidence support that netrin-1 involves in colorectal carcinogenesis.

Objective: This study was to evaluate the performance of serum netrin-1 for detection of colorectal cancer (CRC) in both clinical/screening sets.

Methods: A total of 115 consecutive patients with CRC and matched healthy controls were included in Clinical Set. Read More

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http://dx.doi.org/10.3233/CBM-190340DOI Listing

Four genes relevant to pathological grade and prognosis in ovarian cancer.

Cancer Biomark 2020 May 13. Epub 2020 May 13.

Department of Gynecological Tumors, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Background: Ovarian cancer is the common tumor in female, the prognostic of which is influenced by a series of factors. In this study, 4 genes relevant to pathological grade in ovarian cancer were screened out by the construction of Weighted gene co-expression network analysis.

Methods: GSE9891 with 298 ovarian cancer cases had been used to construct co-expression networks. Read More

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http://dx.doi.org/10.3233/CBM-191162DOI Listing

Clinical value of CD25/CD123 co-expression in acute myeloid leukemia patients.

Cancer Biomark 2020 May 9. Epub 2020 May 9.

Hematology Unit, Clinical Pathology Department, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.

Background: This study aimed to assess the significance of combined expression of interleukin-2 receptor (CD25) and the interleukin-3 receptor (CD123) in acute myeloid leukemia (AML) patients.

Methods: The expression of CD25 and CD123 on blast cells in bone marrow samples were identified by flowcytometry in 94 patients (⩽ 60 years old) with de novo acute myeloid leukemia (AML) treated at the Mansoura University Oncology Center (MUOC).

Results: Of the 94 samples at diagnosis there were 17 (18. Read More

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http://dx.doi.org/10.3233/CBM-201519DOI Listing
May 2020
1.186 Impact Factor

Higher platelet distribution width is associated with unfavorable prognosis in ovarian cancer.

Cancer Biomark 2020 May 7. Epub 2020 May 7.

Department of Gynaecology and Obstetrics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: Ovarian cancer (OC) is one of the most malignant gynecological cancers. Platelets play a profound role in cancer growth and metastasis. Platelet distribution width (PDW) is an indicator of platelet activation and is altered in malignancies. Read More

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http://dx.doi.org/10.3233/CBM-191190DOI Listing

MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process.

Cancer Biomark 2020 May 9. Epub 2020 May 9.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: EGFR-mutant lung cancer inevitably develops resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs).

Objective: To investigate the clinical relevance of microRNAs (miRNAs) in TKI therapy response and resistance.

Methods: We performed a miRNA PCR array analysis and used The Cancer Genome Atlas (TCGA) database to identify potential miRNAs related to EGFR TKIs resistance. Read More

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http://dx.doi.org/10.3233/CBM-191119DOI Listing

Curcumin inhibits proliferation of hepatocellular carcinoma cells through down regulation of DJ-1.

Cancer Biomark 2020 May 9. Epub 2020 May 9.

Department of Hepatology, Qingdao Sixth People's Hospital, Qingdao, Shandong, China.

PTEN exerts tumor suppressor role through inhibiting PI3K/AKT signaling. DJ-1 plays an oncogenic role through negatively regulation of PTEN expression. Curcumin (Cur) is a phenolic compound extracted from a variety of plant roots, with multiple anti-tumor pharmacological effects. Read More

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http://dx.doi.org/10.3233/CBM-190427DOI Listing

Claudin-6 is down-regulated in gastric cancer and its potential pathway.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Claudins are indispensible in modulating the permeability of epithelial and endothelial cells and in the maintenance of cell polarity. In order to verify the function of claudin-6 in the development of gastric cancer, we investigated claudin-6 expression in different gastric disease tissues. Moreover, we further explored whether overexpression of claudin-6 altered proliferation, apoptosis, migration, invasiveness, differentiation in BGC-823 cells and the potential mechanism. Read More

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http://dx.doi.org/10.3233/CBM-201554DOI Listing
April 2020
1.186 Impact Factor

Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatment are currently lacking.

Objective: The purpose of this study was to evaluate the prognostic significance of pretreatment serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen-125 (CA-125) in primary epithelial ovarian cancer. Read More

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http://dx.doi.org/10.3233/CBM-201455DOI Listing

High expression of IGF2-derived intronic miR-483 predicts outcome in hepatoblastoma.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

Background: The role of microRNAs (miRs) as biomarkers to predict outcome in hepatoblastoma (HB), the most common malignant liver tumor in childhood, has still to be determined. Recently, the so-called four-miR signature has been described to efficiently stratify HB patients according to their prognosis.

Objective: We examined the recently described four-miR signature for its clinical relevance in an independent validation cohort of HB patients and tried to optimize its predictive value by analyzing four additional miRs involved in HB biology. Read More

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http://dx.doi.org/10.3233/CBM-191390DOI Listing

Prognostic value of miR-892a in gastric cancer and its regulatory effect on tumor progression.

Cancer Biomark 2020 ;28(2):247-254

Department of Pathology, Caoxian People's Hospital of Shandong, Heze, Shandong, China.

Background: Gastric cancer is a prevalent malignant around the world. Aberrantly expression of microRNAs (miRNAs) contributes to the progression of tumors. The aim of this study was to investigate the expression and role of miR-892a in gastric cancer. Read More

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http://dx.doi.org/10.3233/CBM-191323DOI Listing
January 2020

LINC00174 is a favorable prognostic biomarker in glioblastoma via promoting proliferative phenotype.

Cancer Biomark 2020 Apr 27. Epub 2020 Apr 27.

Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aims: To investigate the expression pattern, prognostic value and biological functional of LINC00174 in glioma.

Methods: In total, 140 glioma samples were collected as discovery cohort. TCGA RNA sequence dataset was obtained as validation set. Read More

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http://dx.doi.org/10.3233/CBM-191026DOI Listing

Immunosuppressive receptor LILRB1 acts as a potential regulator in hepatocellular carcinoma by integrating with SHP1.

Cancer Biomark 2020 Apr 26. Epub 2020 Apr 26.

Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, Shaanxi, China.

Background: Immunosuppressive receptor LILRB1 regulates tumors progression by transducing immune inhibitory signals via intracellular immunoreceptor tyrosine-based inhibitory motifs. However, its role in Hepatocellular Carcinoma (HCC) remains vague.

Objective: This study is aimed to disclose the association between LILRB1 and HCC. Read More

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http://dx.doi.org/10.3233/CBM-190940DOI Listing
April 2020
1.186 Impact Factor

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.

Cancer Biomark 2020 ;28(2):255-268

"CI Parhon" National Institute of Endocrinology, Bucharest, Romania.

Purpose: DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local DNA methylation status and to establish the levels of important DNA methylation regulators (TET family and DNMT1) in thyroid tumours: follicular adenoma-FA, papillary thyroid carcinoma-PTC (classic papillary thyroid carcinoma-cPTC and papillary thyroid carcinoma follicular variant fvPTC).

Methods: Global DNA methylation profile in thyroid tumours tissue (41 paired samples) was assessed by 5-methylcytosine and 5-hydroxymethylcytosine levels evaluation (ELISA), along with TETs and DNMT1 genes expression quantification. Read More

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http://dx.doi.org/10.3233/CBM-190871DOI Listing
January 2020

5-aminolevulinic-acid-mediated sonodynamic therapy improves the prognosis of melanoma by inhibiting survivin expression.

Cancer Biomark 2020 Apr 26. Epub 2020 Apr 26.

Department of Oral Medicine, Jining Medical College, Shandong, China.

Background: This study aimed to evaluate the relationship between survivin expression and tumor after 5-aminolevulinic acid (5-ALA)-mediated sonodynamic therapy.

Methods: Immunohistochemistry was used to detect survivin protein expression in human melanoma clinical samples. Subsequently, the effects of 5-ALA-mediated sonodynamic therapy were determined by measuring the volume of melanoma xenografts and the bodyweights of melanoma-bearing nude mice. Read More

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http://dx.doi.org/10.3233/CBM-190681DOI Listing

Circular RNA circ_0000337 contributes to osteosarcoma via the iR-4458/BACH1 pathway.

Authors:
Yuan Fang Fang Long

Cancer Biomark 2020 Apr 24. Epub 2020 Apr 24.

Department of Research and Teaching Department, Hanzhong Central Hospital, Hanzhong, Shaanxi, China.

Background: As the most prevalent primary bone malignancy in children and adolescents, osteosarcoma (OS) has attracted increasing attention. The role of circRNAs in OS has been elucidated in some reports, but many circRNAs remain unexplored. Circ_0000337 has only been revealed as an oncogenic circRNA in esophageal squamous cell carcinoma. Read More

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http://dx.doi.org/10.3233/CBM-190647DOI Listing

Identifying the mRNAs associated with Bladder cancer recurrence.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Department of Urology, First Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, China.

Object: To identify the mRNAs associated with bladder cancer (BC) recurrence.

Methods: The transcription profile of GSE31684 including 39 recurrent BC tumor samples and 54 non-recurrent BC tumor samples as well as transcription profile of GSE13507 including 36 recurrent BC tumor samples and 67 non-recurrent BC tumor samples were downlaoded from the Gene Expression Omnibus. Then, the differentially expressed genes (DEGs) were identified using linear models for microarray data (limma) and the intersections of DEGs from the two datasets were further screened. Read More

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http://dx.doi.org/10.3233/CBM-190617DOI Listing

Expression of FOXM1 and Aurora-A predicts prognosis and sorafenib efficacy in patients with hepatocellular carcinoma.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Effective prognostic biomarkers and powerful target-therapeutic drugs are needed for improving the treatment of Hepatocellular carcinoma (HCC).

Objective: This study aimed to evaluate the expression of FOXM1 and Aurora-A and their prognostic value in HCC.

Methods: We determined the differentially expressed genes signature in HCC using the Gene Set Enrichment Analysis (GSEA), and then evaluated the expression of FOXM1 and Aurora-A in TCGA and KMUH cohort. Read More

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http://dx.doi.org/10.3233/CBM-190507DOI Listing

CD133 expressionand clinicopathologic significance in benign and malignant breast lesions.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Department of Pathology, Kunming General Hospital, Kunming, Yunnan, China.

Background/objective: CD133 is the molecular marker of normal stem cells and progenitor cells and also confirmed as a marker for cancer stem cells in various tumors. The aim of this study is to examine the expression of CD133 and assess its clinicopathologic significance in benign and malignant breast lesions.

Methods: We analyzed the distribution of CD133 positive cells in breast usual ductal hyperplasia, atypical ductal hyperplasia (ADH), breast ductal carcinoma in situ (DCIS), and invasive breast carcinomas. Read More

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http://dx.doi.org/10.3233/CBM-190196DOI Listing
April 2020
1.186 Impact Factor

Circulating cell-free DNA (cfDNA) levels in BRCA1 and BRCA2 mutation carriers: A preliminary study.

Cancer Biomark 2020 Apr 10. Epub 2020 Apr 10.

Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Israel.

Background: Female carriers of BRCA1 or BRCA2 germline mutations are at a substantially increased risk for developing breast and ovarian cancer. The lack of effective early detection schemes for ovarian cancer, mandate surgical removal of adnexa at age 35-40 years in these high-risk women. The role of circulating cell-free DNA (cfDNA) levels as a marker for early detection in high-risk women has rarely been reported. Read More

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http://dx.doi.org/10.3233/CBM-190718DOI Listing