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    932 results match your criteria Cancer Biomarkers [Journal]

    1 OF 19

    The targeted regulation of Gli1 by miR-361 to inhibit epithelia-mesenchymal transition and invasion of esophageal carcinoma cells.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Ocology Department, Chengde Medical College Affiliated Hospital, Chengde, Hebei, China.
    Epithelia-mesenchymal transition (EMT) is critical for invasion and metastasis of esophageal carcinoma. Gli1, a transcriptional factor in Hedgehog pathway, is correlated with EMT, invasion and metastasis of tumors. However, its role in esophageal cancer is still unknown. Read More

    MiRNA373 induces cervical squamous cell carcinoma SiHa cell apoptosis.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun 130041, Jilin, China.
    Objective: Cervical squamous cell carcinoma seriously threats to patient's life and health. MiRNAs have role of regulating cell growth, proliferation, and death. MiRNAs can promote or inhibit cell growth and proliferation. Read More

    Identification of serum miR-124 as a biomarker for diagnosis and prognosis in osteosarcoma.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
    Background: It has been demonstrated that microRNAs (miRNAs) play an important role in the carcinogenesis of osteosarcoma.

    Objective: The aim of the present study was to determine the diagnostic and prognostic value of serum miR-124 in osteosarcoma.

    Methods: The serum miR-124 expression levels in 114 osteosarcoma patients, 40 periostitis patients and 50 normal controls were detected using real-time quantitative polymerase chain reaction (RT-qPCR). Read More

    Methods and significance of the combined detection of HER2 gene amplification and chemosensitivity in gastric cancer.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Shenzhen Baoan Hospital of Traditional Chinese Medicine (Group), Shenzhen 518133, Guangdong, China.
    Objective: This study aims to investigate the significance of combined detection of HER2 gene amplification and chemosensitivity in gastric cancer.

    Methods: Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and fluorescence reverse-transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of HER2 protein, HER2 gene amplification and the mRNA expression of ERCC1, TUBB3 and TYMS genes in 135 cases of gastric carcinoma.

    Results: The expression rate of HER2 protein was 39. Read More

    Plasma 3,3',5-Triiodo-L-thyronine [T3] level mirrors changes in tumor markers in two cases of metastatic cancer of the breast and pancreas treated with exogenous L-T3.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Clinical Research Unit, ConsorciSanitari del Garraf, Vilanova i la Geltrú, Spain.
    Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine). Read More

    Utility of paraneoplastic antigens as biomarkers for surveillance and prediction of recurrence in ovarian cancer.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
    Background: Ovarian cancer is frequently diagnosed at an advanced stage and 70% of patients experience recurrence months to years from initial diagnosis. The expression of paraneoplastic antigens can result in the occurrence of onconeural autoantibodies in ovarian cancer that may be associated with neurological disorders that are clinically manifested in patients before diagnosis of ovarian cancer. These paraneoplastic antigens can serve as excellent biomarkers not only for early detection but also for monitoring ovarian cancer recurrence. Read More

    MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Yunnan, China.
    MicroRNAs are a class of small non-coding RNA molecules that play crucial roles in the initiation and progression of lung cancer. This study was undertaken to investigate the expression and roles of miR-186 in lung cancer. Ectopic expression experiments demonstrated that miR-186 functions as a tumor suppressor. Read More

    Adrenalectomy was recommended for patients with subclinical Cushing's syndrome due to adrenal incidentaloma.
    Cancer Biomark 2017 Oct 31. Epub 2017 Oct 31.
    Objective: To assess whether adrenalectomy may improve biochemical and metabolic impairment for patients with subclinical Cushing syndrome (SCS) due to adrenal incidentaloma (AI) compared with conservative management.

    Methods: A total of 87 patients with SCS due to AI in Peking Union Medical College Hospital between September 2011 and January 2016 have been treated. Forty-eight patients underwent laparoscopic adrenalectomy (operative group), whereas 39 were managed conservatively (control group). Read More

    miR-30a-5p together with miR-210-3p as a promising biomarker for non-small cell lung cancer: A preliminary study.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Medical Biochemistry, Faculty of Health Sciences with the Division of Nursing and Midwifery, Medical University of Lodz, Lodz, Poland.
    Background: Although an immense effort has been made to develop novel diagnostic methods and treatment strategies for non-small cell lung cancer (NSCLC), the survival rate of this disease has remained virtually unchanged. Small non-coding RNAs called microRNAs (miRNAs) have appeared to be very promising biomarkers of cancer including NSCLC.

    Objective: We investigated the expression level of six miRNAs, and subsequently we evaluated their diagnostic ability and their clinical significance. Read More

    Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
    Objective: To evaluate the correlation of katanin P60 expression with clinicopathological grade and overall survival (OS) in patients with breast cancer (BC).

    Methods: Three hundred and four operative BC patients were retrospectively reviewed in this cohort study. Tumor tissue sample was acquired from each patient during surgery. Read More

    PD98059 impairs the cisplatin-resistance of ovarian cancer cells by suppressing ERK pathway and epithelial mesenchymal transition process.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, China.
    Background: The study was aimed at investigating the role of PD98059 on impairing the cisplatin-resistance of ovarian cancer cells and figuring out the potential mechanism.

    Material And Methods: Treated with low dose of cisplatin (DDP), DDP-resistant ovarian cancer cells were built and named as SKOV-3/DDP. The cell viabilities of ovarian cancer cell line SKOV-3 and SKOV-3/DDP were detected using MTT assay. Read More

    Inhibition of miR-155, a therapeutic target for breast cancer, prevented in cancer stem cell formation.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Background: Breast cancer is a common cancer in women of worldwide. Cancer cells with stem-like properties played important roles in breast cancer, such as relapse, metastasis and treatment resistance. Micro-RNA-155 (miR-155) is a well-known oncogenic miRNA overexpressed in many human cancers. Read More

    Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
    Cancer Biomark 2017 Oct 19. Epub 2017 Oct 19.
    Cervical cancer is the fourth most common malignancy among women worldwide, and continued research to discover biomarkers or therapeutic targets will aid early diagnosis and treatment of this cancer. Here, we investigated novel cervical cancer biomarkers using integrated analysis of high-throughput sequencing data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. We have identified nine genes of interest that appear to be involved in cervical cancer development: SPARCL1, SYCP2, KIF4A, PRC1, TOP2A, LAMP3, KIF20A, MCM2, and APOBEC3B. Read More

    Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy.
    Background: Pancreatic adenocarcinoma (PDAC) is one of the deadliest human malignancies. Although surgery is currently the only effective treatment for PDAC, most patients survive less than 20 months after tumor resection.

    Objective: The primary goal was to investigate alterations in KRAS, TP53, SMAD4 and CDKN2A/p16 in tumors from patients with exceptionally long survival after surgery. Read More

    Squamous cell carcinoma antigen, platelet distribution width, and prealbumin collectively as a marker of squamous cell cervical carcinoma.
    Cancer Biomark 2017 Oct 19. Epub 2017 Oct 19.
    Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China.
    Background: Squamous cell cervical carcinoma is the most common gynecological malignant disorder worldwide. Early detection of squamous cell cervical carcinoma is needed for proper clinical management. Squamous cell carcinoma antigen (SCCA) is commonly used as a tumor marker for squamous cell cervical carcinoma. Read More

    Increase in CIP2A expression is associated with cisplatin chemoresistance in gastric cancer.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Laboratory of Molecular Target Therapy of Cancer, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, China.
    Background: The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein which involves in the progression of several human malignancies. Development of cisplatin (DDP) resistance is the obstacle to an effective control of gastric cancer (GC) clinically.

    Objective: We thus assessed whether CIP2A expression is associated with sensitivity of GC to DDP. Read More

    Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma.
    Cancer Biomark 2017 Oct 18. Epub 2017 Oct 18.
    Department of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
    Background: Circular RNAs (circRNAs) have been found playing important roles in regulating cancer progression. Human circRNA microarray was performed to screen for abnormally expressed circRNA in gastric cancer tissues. In this study, we are aimed to investigate the relationship between a new circular RNA named hsa_circ_0000520 and gastric cancer development. Read More

    Serum miR-542-3p as a prognostic biomarker in osteosarcoma.
    Cancer Biomark 2017 Oct 18. Epub 2017 Oct 18.
    Department of Traumatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong China.
    Objective: Emerging evidence has suggested that circulating microRNAs (miRNAs) in body fluids have novel diagnostic and prognostic significance for patients with malignant diseases. The lack of useful biomarkers is a crucial problem of osteosarcoma (OS); Previous study has reported that miR-542-3p was significantly upregulated in osteosarcoma tissues and miR-542-3p may be as an oncogene in osteosarcoma pathogenesis. In our study, we investigated the circulating miR-542-3p and its clinical relevance in osteosarcoma. Read More

    Propofol induces apoptosis of breast cancer cells by downregulation of miR-24 signal pathway.
    Cancer Biomark 2017 Oct 18. Epub 2017 Oct 18.
    Department of Clinical Laboratory, The Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China.
    Background And Objective: Propofol, an intravenous anesthetic agent, has been found to inhibit growth of breast cancer cells. However, the mechanisms underlying the antitumor are not known. A recent report has found that propofol could significantly downregulate miR-24 expression in the human malignant cancers. Read More

    Single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among Epstein-Barr virus-associated tumors.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Medical Microbiology, Qingdao University Medical College, Qingdao 266021, Shandong, China.
    Background: Gap junction protein beta 2 gene (GJB2) encodes one of connexins- Connexin 26 (Cx26), which mainly expressed in epithelial cells. Cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation.

    Objective: We investigated GJB2 rs2274084 polymorphism in three types of tumors, including nasophoryngeal carcinoma (NPC), gastric cancer (GC) and lymphoma. Read More

    Arylsulfatase B is reduced in prostate cancer recurrences.
    Cancer Biomark 2017 Oct 16. Epub 2017 Oct 16.
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
    Background: Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation. Prior work showed that ARSB immunohistochemical scores were lower in malignant prostate tissue, and were associated with higher Gleason scores and recurrence.

    Objective: This study aims to confirm that ARSB immunostaining of prostate tissue obtained at the time of radical prostatectomy is prognostic for prostate cancer recurrence. Read More

    Targeting of miR-150 on Gli1 gene to inhibit proliferation and cell cycle of esophageal carcinoma EC9706.
    Cancer Biomark 2017 Oct 16. Epub 2017 Oct 16.
    Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, Henan, China.
    Objective: Glioma-associated oncogene homolog 1 (Gli1) in Hedgehog signal pathway regulates Cyclin D1 expression, cell cycle or proliferation modulation. Esophageal cancer patients had significantly elevated Gli1 expression, which is related with survival and prognosis. It has been demonstrated that the level of miR-150 was decreased in esophageal cancer patients compared to normal control. Read More

    MiR-101 reduces cell proliferation and invasion and enhances apoptosis in endometrial cancer via regulating PI3K/Akt/mTOR.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    PI3K/Akt/mTOR signaling pathway plays an important role in tumor development. mTOR overexpression and PI3K/ Akt/mTOR signaling pathway enhancement were found in endometrial cancer (EC). MiR-101 was found downregulated in EC. Read More

    Identification of breast cancer hub genes and analysis of prognostic values using integrated bioinformatics analysis.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    BGI-Shenzhen, Shenzhen 518083, Guangdong, China.
    Background: Breast cancer (BC) is the second most common cause of death from cancer in women in the United States. As the molecular mechanism of BC has not yet been completely discovered, identification of hub genes and pathways of this disease is of importance for revealing molecular mechanism of breast cancer initiation and progression.

    Objective: This study aimed to identify potential biomarkers and survival analysis of hub genes for BC treatment. Read More

    Whole-exome sequencing to identify novel mutations of nevoid basal cell carcinoma syndrome in a Chinese population.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    Background: Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease with a complex genetic etiology. Although three causative genes (PTCH1, PTCH2, SUFU) have been identified through linkage analysis and Sanger sequencing, the genetic background of NBCCS hasn't been fully understood.

    Methods: We performed a whole-exome sequencing (WES) in a Han Chinese NBCCS family and two unaffected volunteers to search for its causative gene. Read More

    Enhanced expression of the long non-coding RNA SNHG16 contributes to gastric cancer progression and metastasis.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    This paper aimed to probe into the expression of long non-coding RNA (lncRNA) SNHG16 in human gastric cancer (GC) and its potential tumor biological functions. The expression of lncRNA SNHG16 was detected in GC and adjacent tissues and GC cell lines using qRT-PCR. GC MGC-803 cells were transfected with siRNA of lncRNA SNHG16, as well as blank and negative control. Read More

    The expression of ER, PR in endometrial cancer and analysis of their correlation analysis of with ERK signaling pathway.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Department of Oncology, The First People's Hospital of Jining City, Jining, Shandong, China.
    Endometrial carcinoma (EC) is a common malignant tumor in gynecology. Its incidence and development are closely associated with the levels of estrogenic and progesterone hormone. Extracellular signal-regulated kinase (ERK) signaling pathway abnormity is associated with a variety of tumors. Read More

    Downregulation of SNHG1 suppresses cell proliferation and invasion by regulating Notch signaling pathway in esophageal squamous cell cancer.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    Department of Thoracic, Jilin Cancer Hospital, Changchun, Jilin, China.
    Background: Long non-coding RNAs (lncRNAs) exert important functions involved in tumorigenesis and cancer progression including esophageal squamous cell cancer (ESCC), however, the clinical role and underlying biological function of Small Nucleolar RNA Host Gene 1 (SNHG1) in ESCC is not well known.

    Methods: Quantitative Real-time polymerase chain reaction (QRT-PCR) was used to detect the SNHG1 expression levels in ESCC tissues and adjacent non-cancerous tissues. Chi-square test was used to evaluate the association between clinicopathological features and SNHG1 expression in ESCC patients, Kaplan-Meier curve and log rank test was performed to analyze the association between overall survival and SNHG1 expression. Read More

    Upregulation of long noncoding RNA PVT1 predicts unfavorable prognosis in patients with clear cell renal cell carcinoma.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, PLA Medical School, Beijing 100853, China.
    Background: Renal cell carcinoma (RCC) is one of the most malignant genitourinary diseases worldwide. Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs in the human genome that are involved in RCC initiation and progression.

    Objective: To investigate the expression of PVT1 in ccRCC and evaluate its correlation with clinicopathologic characteristics and patients' survival. Read More

    MiR-186 inhibits proliferation, migration, and invasion of non-small cell lung cancer cells by downregulating Yin Yang 1.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Background: Non-small cell lung cancer (NSCLC) is the main type of lung cancer. While miR-186 is significantly reduced in lung cancer tissues and cells, its role in NSCLC has not been completely elucidated.

    Material And Methods: We used qRT-PCR and western blot methods to investigate the levels of miR-186 and YY1 in 21 pairs of NSCLC tissues. Read More

    SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
    Cancer Biomark 2017 Oct 9. Epub 2017 Oct 9.
    Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    N-myc downstream regulated gene 2 (NDRG2) is frequently down-regulated in various cancers and functions as a candidate tumor suppressor gene. NDRG2 has been shown to be SUMOylated on the lysine 333 residue, which promoted its ubiquitination and sequentially degradation by the SUMO-targeted ubiquitin E3 ligase RNF4. However, how to regulated NDRG2 deSUMOylation process remains largely unknown. Read More

    miR-34a increases cisplatin sensitivity of osteosarcoma cells in vitro through up-regulation of c-Myc and Bim signal.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Department of Hemopurification Center, Yantaiyuhuangding Hospital, Yantai, Shandong, China.
    Background And Objective: Osteosarcoma is the most common primary malignancy in bone. Patients who respond poorly to induction chemotherapy are at higher risk of adverse prognosis. The molecular basis for such poor prognosis remains unclear. Read More

    Primary cardiac sarcoma complicated with cerebral infarction and brain metastasis: A case report and literature review.
    Cancer Biomark 2017 Oct 9. Epub 2017 Oct 9.
    The Cardiac Surgery Department, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
    In large autopsy series, the estimated frequency of primary tumors of the heart ranges from 0.0017% to 0.33%. Read More

    Downregulation of tissue miR-338-3p predicts unfavorable prognosis of gastric cancer.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
    Numerous studies have proved that microRNAs (miRNAs) play crucial roles in the tumorigenesis and progression of gastric cancer (GC). Our study was to investigate the correlation between miR-338-3p expression and clinical features as well as prognosis of GC. A total of 138 GC tissue specimens and adjacent non-cancerous tissues were collected for further analysis, then quantitative PCR method was used to detect the relative miR-338-3p expression. Read More

    MicroRNA-937 inhibits cell proliferation and metastasis in gastric cancer cells by downregulating FOXL2.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Background: Despite advancement in the treatment, the mortality of gastric cancer remains high. MicroRNAs (miRNAs) are involved in tumor development and progression by regulating signaling pathways. In this study, we investigated the role of miR-937 in gastric cancer cells. Read More

    Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Background And Aim: Relaxin is a short circulating peptide hormone. The aim of this study was to understand the role of relaxin in progression of epithelial ovarian cancer (EOC) and to assess its diagnostic and prognostic significance.

    Methods: A total of 124 patients with EOC, 46 patients with benign ovarian diseases, and 50 healthy controls were recruited. Read More

    Long intergenic non-protein coding RNA 1006 used as a potential novel biomarker of gastric cancer.
    Cancer Biomark 2017 Oct 9. Epub 2017 Oct 9.
    Background: Accumulating evidences have shown that long non-coding RNAs (lncRNAs), longer than 200 nucleotides in length, play a crucial role in cancer occurrence and development. However, the relationships between most lncRNAs and gastric carcinogenesis remain poorly understood.

    Objective: To explore the diagnostic value of one typical lncRNA, long intergenic non-protein coding RNA 1006 (LINC01006), in gastric cancer. Read More

    Programmed death-1 lignd-1 gene rs2890658 polymorphism associated with the risk of esophageal squamous cell carcinoma in smokers.
    Cancer Biomark 2017 Oct 9. Epub 2017 Oct 9.
    Background: The most important anti-tumor immune response is mediated by T lymphocytes. The interaction of programmed death-1 lignd-1 (PD-L1) with its receptor provides an inhibitory signal in T lymphocytes activation and proliferation.

    Objective: This study aimed to investigate whether polymorphisms of PD-L1 were associated with the risk and prognosis of esophageal squamous cell carcinoma (ESCC) in a high-incidence population from Northern China. Read More

    Breath based volatile organic compounds in the detection of breast, lung, and colorectal cancers: A systematic review.
    Cancer Biomark 2017 Oct 8. Epub 2017 Oct 8.
    Background: Detecting volatile organic compounds (VOCs) could provide a rapid, noninvasive, and inexpensive screening tool for detecting cancer.

    Objective: In this systematic review, we identified specific exhaled breath VOCs correlated with lung, colorectal, and breast cancer.

    Methods: We identified relevant studies published in 2015 and 2016 by searching Pubmed and Web of Science. Read More

    Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.
    Cancer Biomark 2017 Oct 13. Epub 2017 Oct 13.
    Department of Obstetrics and Gynecology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
    Background: Understanding the molecular mechanisms is important in development and therapy of endometrioid endometrial adenocarcinoma.

    Objective: To identify key genes in endometrioid endometrial adenocarcinoma.

    Methods: The data of mRNA, miRNA and DNA methylation were downloaded from The Cancer Genome Atlas (TCGA) database and differential analysis was performed. Read More

    Infiltration of γ⁢δ T cells, IL-17+ T cells and FoxP3+ T cells in human breast cancer.
    Cancer Biomark 2017 Oct 9. Epub 2017 Oct 9.
    Cancer Immunology, Department of Translational Medicine, Lund University, Malmö, Sweden.
    Background: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. Read More

    Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Gastrointestinal Cancer Research Center, Ardabil University of Medical Sciences, Ardabil 56189-53141, Iran.
    Background: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial.

    Objective: We aimed to examine the linkage of H. Read More

    Globo H expression is associated with driver mutations and PD-L1 expressions in stage I non-small cell lung cancer.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan.
    Background: Globo H is a tumor-associated carbohydrate antigen exclusively expressed in cancer cells rather than normal tissue. Globo H has been found on many cancers of epithelial origins, and become an attractive target for cancer vaccine.

    Objectives: We aimed to study the expression of Globo H in non-small cell lung cancer (NSCLC) patients, and correlated its expression with common driver mutations, clinical outcomes, and status of immune checkpoint, programmed death-ligand 1 (PD-L1). Read More

    Predictors for the efficacy of Endostar combined with neoadjuvant chemotherapy for stage IIIA (N2) NSCLC.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
    Background: Endostar (rh-endostatin) is a new recombinant human endostatin, which could inhibit cell proliferation, angiogenesis, and tumor growth.

    Objective: To explore anti-angiogenesis short-term efficacy combined with neoadjuvant chemotherapy for stage IIIA (N2) non-small cell lung cancer (NSCLC), and identify the potential predictive factors.

    Methods: We pathologically examined 26 patients diagnosed with stage IIIA (N2) NSCLC who received NP chemotherapy alone or combined with Endostar, respectively. Read More

    Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
    Besides the crucial role of hyperinsulinemia in the development of breast cancer with Type 2 diabetes mellitus (T2DM), it has been shown that hyperglycemia could contribute to promote cancer progression. A remarkable association within hyperglycemia, PKCδ and Ubiquitin-proteasome system (UPS) has been reported, suggesting that PKCδ may mediate high glucose-induced UPS activation in breast cancer cells. Although the independent effects of PKCδ or UPS on breast cancer and T2DM are increasingly supported by experimental evidence, the complex interactional link between PKCδ and UPS is still unclear. Read More

    Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
    Objective: Colon cancer-associated transcript 2 (CCAT2), a novel lncRNA has been reported as an oncogene in several cancers. This study was aimed to explore whether CCAT2 also exerted oncogenic roles in endometrial cancer cells.

    Materials And Methods: The expression of CCAT2 in 30 pairs of endometrial cancer and matched non-cancerous tissues were detected by qRT-PCR. Read More

    Evaluation of serum CCL18 as a potential biomarker for ovarian cancer.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
    Background: Early detection and differentiation diagnosis of a pelvic mass (PM) is crucial in improving the prognosis of patients with epithelial ovarian cancer (EOC). C-C motif chemokine ligand 18 (CCL18) was reported as a chemokine-mediated tumor-related inflammation that can be detected in serum and may correlate with cancer patients' prognosis.

    Objective: We performed this study to investigate the relationship between CCL18 levels and clinical characteristics of EOC patients, and to explore their diagnostic and prognostic values. Read More

    Pancreatic cancer and associated exosomes.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Department of Clinical Laboratory, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, China.
    Pancreatic cancers with poor prognosis are highly malignant, readily metastatic and of immune tolerance, mainly due to delayed detection. The metastatic progression and immune tolerance of pancreatic cancer is greatly attributed to the intercellular communication. However, exosomes are deemed to be the most important tool of intercellular communicators. Read More

    Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment.
    Cancer Biomark 2017 Sep 29. Epub 2017 Sep 29.
    Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
    Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined.

    Objective: We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin- cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions. Read More

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