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    970 results match your criteria Cancer Biomarkers [Journal]

    1 OF 20

    Expression of CD105 cancer stem cell marker in three subtypes of renal cell carcinoma.
    Cancer Biomark 2017 Dec 20. Epub 2017 Dec 20.
    Oncopathology Research Centre.
    Background: CD105 is recently described as a cancer stem cell (CSC) marker.

    Objective: The present study was aimed to investigate the expression and prognostic significance of the CSC marker CD105 in different histological subtypes of renal cell carcinoma (RCC).

    Methods: Expression of CD105 was evaluated using immunohistochemistry in RCC samples on tissue microarrays including clear cell RCCs (ccRCCs), papillary, and chromophobe RCCs. Read More

    Platelet indices in laryngeal cancer.
    Cancer Biomark 2017 Dec 22. Epub 2017 Dec 22.
    Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China.
    Background: Laryngeal cancer is one of the most common malignancies in the head and neck. Activated platelets play a critical role in cancer development and progression. Altered mean platelet volume (MPV) and platelet distribution width (PDW) have been found in various types of cancer. Read More

    lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma.
    Cancer Biomark 2017 Dec 22. Epub 2017 Dec 22.
    Department of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
    Background: Chronic hepatitis C (CHC) is a contagious liver disease that results from infection with the hepatitis C virus (HCV). The most serious consequence of CHC is HCV-related hepatocellular carcinoma (HCC).

    Objective: To illustrate the clinical significance of lncRNA HEIH expression in serum and exosomes in the development of HCV-related HCC. Read More

    Tumor-infiltrating lymphocytes are associated with β-catenin overexpression in breast cancer.
    Cancer Biomark 2017 Dec 22. Epub 2017 Dec 22.
    Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
    Background: Inhibition of lymphocytes infiltration and activity may impair antitumor immune response and limit treatment responsiveness. Wnt/β-catenin pathway has been suggested to contribute to immune evasion in tumor by suppressing the function of immune cells and excluding T cell infiltration. However, the effects of Wnt/β-catenin on TILs recruitment remain controversial. Read More

    Resveratrol enhances the effects of ALA-PDT on skin squamous cells A431 through p38/ MAPK signaling pathway.
    Cancer Biomark 2017 Dec 23. Epub 2017 Dec 23.
    Department of Dermatology, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, Inner Mongolia, China.
    Aims And Background: Squamous cell carcinoma (SCC) is one of the most common skin cancers. Photodynamic therapy (PDT) is a non-invasive treatment for SCC, but it is usually effective only on tumors just under the skin. Resveratrol (Res) is a polyphenolic compound, which is capable of promoting apoptosis of a variety of cancer cells. Read More

    Knockdown of lncRNA GHET1 suppresses cell proliferation, invasion and LATS1/YAP pathway in non small cell lung cancer.
    Cancer Biomark 2017 Dec 22. Epub 2017 Dec 22.
    Background: The aim in this study was to explore the role of long non-coding RNA GHET1 in development of non small cell lung cancer (NSCLC).

    Methods: LncRNA GHET1 expression levels were analyzed by qRT-PCR in tumor tissues and adjacent normal tissues in NSCLC. Measuring the cell proliferation and invasion abilities by CCK8, cell colony formation and transwell invasion assays. Read More

    CD9 expression indicates a poor outcome in acute lymphoblastic leukemia.
    Cancer Biomark 2017 Dec 20. Epub 2017 Dec 20.
    Objective: We undertook a single-center retrospective study to determine the relationship between CD9 and acute lymphoblastic leukemia (ALL).

    Materials And Methods: In total, 112 newly diagnosed patients in our center were enrolled in the study. Their clinical information was collected and the patients werefollowed over the course of the study. Read More

    Protein and DNA evidences of HCMV infection in primary breast cancer tissues and metastatic sentinel lymph nodes.
    Cancer Biomark 2017 Dec 19. Epub 2017 Dec 19.
    Department of Microbiology, Qingdao University Medical College, Qingdao, Shandong 266071, China.
    Background And Objective: Breast cancer is the leading cause of death in women worldwide. There are evidences that human cytomegalovirus (HCMV) infection is associated with several malignant tumors. This study aims to investigate the infection of human cytomegalovirus (HCMV) in a large sample of breast cancer patients, and conduct a correlation analysis of clinical and pathological factors, to provide evidence for whether HCMV infection is associated with breast cancer development, progression and metastasis. Read More

    Upregulation of serum miR-494 predicts poor prognosis in non-small cell lung cancer patients.
    Cancer Biomark 2017 Dec 18. Epub 2017 Dec 18.
    Objective: Emerging studies show that microRNAs (miRNAs) play a essential role in tumorigenesis. Deregulation of miR-494 is frequently observed in various human cancers including non-small cell lung cancer (NSCLC). However, little is known about the clinical significance of serum miR-494. Read More

    Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, Guangdong, China.
    Background: The long non-coding RNA FOXD2-AS1 is highly expressed in non-small cell lung cancer and promotes malignant progression. However, the role of FOXD2-AS1 in esophageal squamous cell carcinoma (ESCC) is still unclear.

    Objective: In this study, we examined the relationships between the expression level of FOXD2-AS1 and the outcome of ESCC patients. Read More

    TP53 p.R72P genotype is a marker of poor prognosis in lung cancer.
    Cancer Biomark 2017 Dec 18. Epub 2017 Dec 18.
    Laboratorio de Oncología Molecular, IUOPA and Laboratorio de Medicina, HUCA, Oviedo, Spain.
    Background: Lung cancer is a leading cause of death worldwide, with poor survival rates despite diagnostic and therapeutic advances. Markers are needed in order to improve clinical patient management and survival. TP53 is frequently involved in lung cancer development with polymorphic sites potentially having a role in it. Read More

    Rule of changes in serum GGT levels and GGT/ALT and AST/ALT ratios in primary hepatic carcinoma patients with different AFP levels.
    Cancer Biomark 2017 Dec 22. Epub 2017 Dec 22.
    Objective: This study aims to explore the rule of changes in serum GGT activity, as well as GGT/ALT and AST/ALT ratios, in primary hepatic carcinoma (PHC) patients with different alpha-fetal protein (AFP) levels.

    Methods: GGT, AST and ALT were detected in 370 PHC patients with positive HBs-Ag using a automatic biochemical analyzer, and AFP was detected using a Roche E170 modular analytics immunoassay analyzer. GGT level, as well as AST/ALT and GGT/ALT, ratios were compared among PHC patients with different AFP levels. Read More

    Combination of preoperative D-dimer and mean platelet volume predicts postoperative deep venous thrombosis in breast cancer patients.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, Heilongjiang, China.
    Background: Deep venous thrombosis (DVT) is associated with severe morbidity and mortality in cancer. Mean platelet volume (MPV) is an indicator of activated platelets.

    Objective: We aimed to investigate whether the combination of D-dimer and MPV could have a better performance in predicting deep venous thrombosis (DVT) in patients with breast cancer. Read More

    EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Medical Oncology, University Hospital of Pisa, 56126 Pisa, Italy.
    Purpose: The evaluation of molecular targets in gastric cancer has demonstrated the predictive role of HER2 amplification for trastuzumab treatment in metastatic gastric cancer. Besides HER2, other molecular targets are under evaluation in metastatic gastric tumors. However, very little is known about their role in resected tumors. Read More

    Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
    Background And Aim: Hypercalcemia is a potentially fatal and not rare complication of hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear. Parathyroid hormone (PTH) is the most important regulator of the concentrations of calcium and phosphate in blood; parathyroid hormone-related protein (PTHrP) was the most frequent cause of humoral hypercalcemia of malignancy; parathyroid hormone 1 receptor (PTH1R) is the common receptor for PTH and PTHrP. The aim of this study is to investigate the expression of PTH, PTHrP, and PTH1R in HCC tissues, and their relationship with clinical pathological characters in HCC. Read More

    MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China.
    Objective: MicroRNAs are widely thought to play a regulatory role in gene expression. Although the more unique microRNA expression profiles have been reported in several tumors, there remains a scarcity of knowledge in relation to microRNA expression profiles in GISTs. During this study, through the alteration in the expression of microRNA-152 (miR-152) in gastrointestinal stromal tumor (GIST) cells, we subsequently evaluated its ability to influence the processes associated with cancer, including proliferation, migration, invasion, and apoptosis, as well as the associated mechanisms. Read More

    Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Department of General Surgery, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong, China.
    Background: This research was aimed to study the expression of Serine/arginine rich splicing factor 2 (SRSF2) in tissues of hepatocellular carcinoma, and explore the relationship between the expression and the clinic pathological and prognosis of human hepatocellular carcinoma (HCC).

    Methods: One hundred and fifty-three pairs HCC tissues and adjacent normal tissue were collected from January 2010 to March 2013. The expression of SRSF2 gene was detected by immunohistochemistry, western blotting and real-time quantitative polymerase chain reaction (PCR), and the relationship between the expression and the clinic pathological and prognosis of HCC being analyzed. Read More

    Effects of exogenous IL-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T cells.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Department of Pathology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China.
    Background: This study aims to investigate the effects of exogenous interleukin (IL)-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T (Treg) cells.

    Methods: After isolating the CD4+ CD25+ Treg cells from the peripheral blood, flow cytometry was used to detect the purity of the Treg cells. A549 cells were divided into blank (no transfection), empty plasmid (transfection with pIRES2-EGFP empty plasmid) or IL-37 group (transfection with pIRES2-EGFP-IL-37 plasmid). Read More

    Hypermethylation pattern of ESR and PgR genes and lacking estrogen and progesterone receptors in human breast cancer tumors: ER/PR subtypes.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Cancer Institute, Tehran University of Medical Sciences/Day General Hospital, Tehran, Iran.
    Background: The option of endocrine therapy in breast cancer remains conventionally promising.

    Objective: We aimed to investigate how accurately the pattern of hypermethylation at estrogen receptor (ESR) and progesterone receptor (PgR) genes may associate with relative expression and protein status of ER, PR and the combinative phenotype of ER/PR.

    Methods: In this consecutive case-series, we enrolled 139 primary diagnosed breast cancer. Read More

    Overexpression of lncRNA ANRIL promoted the proliferation and migration of prostate cancer cells via regulating let-7a/TGF-β1/ Smad signaling pathway.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Faculty of Nursing, Kunming Medical University, Kunming, Yunnan, China.
    Long non-coding RNAs (lncRNAs) were playing critical roles in tumorigenesis. However, in prostate cancer, the roles and mechanisms of lncRNAs especially ANRIL were largely unknown. We investigated the effects of ANRIL on the proliferation and migration of prostate cancer cells using CCK-8 assay and Transwell migration assay. Read More

    Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Centre of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, 56124 Pisa, Italy.
    Background: The role of serum biomarkers in the surveillance of hepatocellular carcinoma (HCC) is controversial.

    Objective: We assessed the diagnostic performances of alpha-fetoprotein (AFP) and protein-induced by vitamin-K-absence/antagonist-II (PIVKA-II) in 388 cirrhotic patients with chronic liver disease (CLD).

    Methods: Biomarkers were quantified by automated chemiluminescent-enzyme-immunoassays (Fujirebio, Tokyo, Japan) at HCC diagnosis in 258 patients (204 males; median age 66. Read More

    Deregulation of sialidases in human normal and tumor tissues.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Institute of Pathology, Locarno, Switzerland.
    Background: Aberrant sialylation is a characteristic feature associated with cancer. The four types of mammalian sialidases identified to date have been shown to behave in different manners during carcinogenesis. While NEU1, NEU2 and NEU4 have been observed to oppose malignant phenotypes, the membrane-bound sialidase NEU3 was revealed to promote cancer progression. Read More

    Elevated levels of serum nidogen-2 in esophageal squamous cell carcinoma.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
    Background: Nidogen-2 (NID2), a secretory basement membrane protein, has been implicated as a potential biomarker in ovarian cancer and hepatocellular carcinoma.

    Objective: In this study, we aimed to investigate the utility of detecting serum NID2 levels for identification of esophageal squamous cell carcinoma (ESCC) patients and prediction of poor survival outcome.

    Methods: Using an in-house NID2 enzyme-linked immunosorbent assay (ELISA), serum samples from 101 ESCC patients and 50 healthy controls were screened for their NID2 levels. Read More

    LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma.
    Cancer Biomark 2017 Dec 8. Epub 2017 Dec 8.
    Background: Recent findings have identified thousands of long non-coding RNAs (lncRNAs) and reveal that lncRNAs play crucial roles in the regulation of tumor development and progression. However, the clinical significance and potentially functional value of LINC00261 in hepatocellular carcinoma (HCC) remain unknown.

    Methods: Expression of LINC00261 was detected by qRT-PCR in HCC tissues and adjacent normal tissues. Read More

    Silencing the autophagy-specific gene Beclin-1 contributes to attenuated hypoxia-induced vasculogenic mimicry formation in glioma.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Objective: To explore the influence of Beclin-1 on vasculogenic mimicry (VM) induced by hypoxia in glioma.

    Methods: CD34-PAS staining was carried out to observe VM formation, and immunohistochemistry was used to determine the expression levels of Beclin-1, HIF-1α, VEGF and MMP2 in 105 patients with primary glioma. Human glioma U87MG cells were divided into Normoxia, Hypoxia, Hypoxia + NC siRNA and Hypoxia + Beclin-1 siRNA groups. Read More

    Increased high-mobility group A2 correlates with lymph node metastasis and prognosis of non-small cell lung cancer.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Background: High-mobility group A2 (HMGA2) has been investigated to be associated with tumorigenesis; however, the expression pattern and clinical significance of HMGA2 in non-small cell lung cancer (NSCLC) remains poorly understood. The purpose of this study is to examine the expression of HMGA2 and to analyze its relationships with respect to clinico-pathological features and patient survival in NSCLC.

    Methods: The expression level of HMGA2 was examined by Western blot and immunohistochemistry in NSCLC cells and tissues. Read More

    Identification of mannose receptor and CD163 as novel biomarkers for colorectal cancer.
    Cancer Biomark 2017 Nov 30. Epub 2017 Nov 30.
    Department of Gastrointestinal Surgery, Jingmen First People's Hospital, Jingmen 448000, Hubei, China.
    The aim of present study was to investigate the clinical significances of mannose receptor (MR) and CD163 in colorectal cancer (CRC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) were utilized for this analysis. Preoperative serum MR and CD163 levels ranged from 0. Read More

    The clinical significance of the combined detection of serum Smac, HE4 and CA125 in endometriosis-associated ovarian cancer.
    Cancer Biomark 2017 Nov 30. Epub 2017 Nov 30.
    Department of Gynaecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China.
    Objective: This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC).

    Methods: The level of serum Smac, HE4 and CA125 in 40 healthy controls, 40 cases of benign endometriosis ovarian tumor, and 60 cases of EAOC were detected by ELISA and electrochemical immune method.

    Results: Serum Smac expression level was significantly lower in the EAOC group than in the control group and benign ovarian tumor group (P< 0. Read More

    Prostate cancer detection using machine learning techniques by employing combination of features extracting strategies.
    Cancer Biomark 2017 Nov 28. Epub 2017 Nov 28.
    Department of CS and IT, The University of Azad Jammu and Kashmir, Muzaffarabad, Azad Kashmir, Pakistan.
    Prostate is a second leading causes of cancer deaths among men. Early detection of cancer can effectively reduce the rate of mortality caused by Prostate cancer. Due to high and multiresolution of MRIs from prostate cancer require a proper diagnostic systems and tools. Read More

    Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor PROKR2 are associated to human colorectal cancer progression and peritoneal carcinomatosis.
    Cancer Biomark 2017 Nov 28. Epub 2017 Nov 28.
    Institut National de la Santé et de la Recherche Médicale, Grenoble, France.
    Background: The highest risk factor for mortality among malignant tumors is metastasis. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic factor which biological activity is mediated via two G protein-coupled receptors, prokineticin receptor1 (PROKR1) and PROKR2. Recent studies suggested that EG-VEGF expression is deregulated in multiple cancers including colorectal cancer (CRC). Read More

    Knockdown of long noncoding RNA FGFR3- AS1 induces cell proliferation inhibition, apoptosis and motility reduction in bladder cancer.
    Cancer Biomark 2017 Nov 27. Epub 2017 Nov 27.
    Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
    Objectives: To study the expression pattern of long non-coding RNA FGFR3 antisense transcript 1(FGFR3-AS1) and the cell proliferation inhibition, apoptosis, and motility changes induced by silencing FGFR3-AS1 in bladder cancer.

    Methods: The differential expression levels of FGFR3-AS1 and FGFR3 in tumor tissues and paired normal tissues were determined using Real-Time qPCR in a total of 36 patients diagnosed with bladder cancer (urothelial carcinoma). Pearson's coefficient correlation was used for expression correlation assay. Read More

    Diagnostic and prognostic relevance of serum miR-195 in pediatric acute myeloid leukemia.
    Cancer Biomark 2017 Nov 27. Epub 2017 Nov 27.
    Background: MicroRNA-195 acts as a tumor suppressor in a variety of cancers. However, its clinical significance in pediatric acute myeloid leukemia (AML) remains largely undefined.

    Objective: To investigate the diagnostic and prognostic relevance of miR-195 in this malignancy. Read More

    Clinical and RNA expression integrated signature for urothelial bladder cancer prognosis.
    Cancer Biomark 2017 Nov 25. Epub 2017 Nov 25.
    Department of Computational Physics, Institute of Modern Physics of Chinese Academy of Sciences, Lanzhou, Gansu, China.
    Background: Accumulating evidence shows that clinical factors alone are not adequate for predicting the survival of patients with urothelial bladder cancer (UBC), and many genes have been found to be associated with UBC prognosis.

    Purpose: The objective of this study is to develop a signature which integrates clinical and molecular information to predict the overall survival of UBC patients more accurate.

    Materials And Methods: We integrated messenger RNA (mRNA) and microRNA (miRNA) expression profiles and the corresponding clinical data of 402 UBC patients and 19 normal controls from The Cancer Genome Atlas. Read More

    Comparative analysis of immune function, hemorheological alterations and prognosis in colorectal cancer patients with different traditional Chinese medicine syndromes.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China.
    Objective: The present study investigates the differences in immune function, hemorheological alterations and prognostic evaluation in colorectal cancer (CRC) patients with different traditional Chinese medicine (TCM) syndromes.

    Methods: A total of 128 patients, diagnosed as stage II and III of CRC, were recruited. They were assigned into three TCM syndromes: deficiency syndrome, excess syndrome, and syndrome of intermingled deficiency and excess, and another 53 healthy individuals were selected as the control. Read More

    High expression of NDRG3 associates with unfavorable overall survival in non-small cell lung cancer.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Geriatric Lung Cancer Research Laboratory, Department of Hematology and Oncology, Jiangsu Province Geriatric Hospital, Nanjing, Jiangsu, China.
    Background And Objective: N-myc downstream-regulated gene 3 (NDRG3) is one of the important members of the NDRG family which crucially take part in cell proliferation, differentiation and other biological processes.

    Methods: In this present study, western-blotting analysis was performed to evaluate NDRG3 expression in NSCLC cell lines. One-step quantitative reverse transcription-polymerase chain reaction (qPCR) with 16 fresh-frozen NSCLC samples and immunohistochemistry (IHC) analysis in 100 NSCLC cases were conducted to explore the relationship between NDRG3 expression and the clinicopathological characteristics of NSCLC. Read More

    Dysregulation of miR-126/Crk protein axis predicts poor prognosis in gastric cancer patients.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 20025, China.
    Background: miR-126 functions as a tumor suppressor in gastric cancer (GC) by negatively regulating Crk protein expression post-transcriptionally.

    Objective: The aim of this study was to investigate the associations of miR-126 and Crk protein expression levels, alone or in combination, with the clinicopathological characteristics and prognosis of GC patients.

    Methods: The expression levels of miR-126 and Crk protein in 338 GC patients were analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. Read More

    Correlation of PD-1/PD-L1 polymorphisms and expressions with clinicopathologic features and prognosis of ovarian cancer.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Department of Obstetrics and Gynecology, The First People's Hospital of Jingzhou City, Jingzhou 434000, Hubei, China.
    Objective: To explore the correlation of PD-1/PD-L1 polymorphisms and their expressions with clinicopathologic features and prognosis of ovarian cancer.

    Methods: A total of 164 patients with ovarian cancer were enrolled as case group and 170 healthy women as control group. We conducted quantitative reverse transcription-PCR (qRT-PCR) to determine PD-1/PD-L1 expressions in peripheral blood mononuclear cells (PBMCs). Read More

    Low-level serum miR-24-2 is associated with the progression of colorectal cancer.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Department of Urology, Jinling Hospital, Nanjing 210002, Jiangsu, China.
    Background: colorectal cancer (CRC) is the second leading cause of cancer and cancer-related death in the world. Noninvasive biomarkers for early diagnosis of CRC are highly demanded.

    Objective: The up-regulation of specific microRNAs (miRNAs) in serum has been considered a promising biomarker of CRC and miR-24-2 may be a potential biomarker in the diagnosis the progression of CRC. Read More

    MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Background: Recent studies have indicated that microRNAs (miRNAs) are closely related to lung cancer. However, the effects of miR-1246 on lung cancer are still elusive. In this study, we aimed to explore the molecular mechanisms of miR-1246 in lung cancer. Read More

    Growth differentiation factor (GDF-15) concentration combined with Ca125 levels in serum is superior to commonly used cancer biomarkers in differentiation of pancreatic mass.
    Cancer Biomark 2017 Nov 17. Epub 2017 Nov 17.
    Department of General and Transplant Surgery, Medical University of Lodz, Lodz, Poland.
    Background: Pancreatic cancer (PDAC) will have been the second leading cancer-related death in the United States by 2020, according to current estimation. Its late manifestation and the lack of good early detection methods are the cause of extremely low survival rates. Therefore, there is an urgent need to develop highly sensitive and specific marker. Read More

    The targeted regulation of Gli1 by miR-361 to inhibit epithelia-mesenchymal transition and invasion of esophageal carcinoma cells.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Ocology Department, Chengde Medical College Affiliated Hospital, Chengde, Hebei, China.
    Epithelia-mesenchymal transition (EMT) is critical for invasion and metastasis of esophageal carcinoma. Gli1, a transcriptional factor in Hedgehog pathway, is correlated with EMT, invasion and metastasis of tumors. However, its role in esophageal cancer is still unknown. Read More

    MiRNA373 induces cervical squamous cell carcinoma SiHa cell apoptosis.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun 130041, Jilin, China.
    Objective: Cervical squamous cell carcinoma seriously threats to patient's life and health. MiRNAs have role of regulating cell growth, proliferation, and death. MiRNAs can promote or inhibit cell growth and proliferation. Read More

    Identification of serum miR-124 as a biomarker for diagnosis and prognosis in osteosarcoma.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
    Background: It has been demonstrated that microRNAs (miRNAs) play an important role in the carcinogenesis of osteosarcoma.

    Objective: The aim of the present study was to determine the diagnostic and prognostic value of serum miR-124 in osteosarcoma.

    Methods: The serum miR-124 expression levels in 114 osteosarcoma patients, 40 periostitis patients and 50 normal controls were detected using real-time quantitative polymerase chain reaction (RT-qPCR). Read More

    Methods and significance of the combined detection of HER2 gene amplification and chemosensitivity in gastric cancer.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Shenzhen Baoan Hospital of Traditional Chinese Medicine (Group), Shenzhen 518133, Guangdong, China.
    Objective: This study aims to investigate the significance of combined detection of HER2 gene amplification and chemosensitivity in gastric cancer.

    Methods: Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and fluorescence reverse-transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of HER2 protein, HER2 gene amplification and the mRNA expression of ERCC1, TUBB3 and TYMS genes in 135 cases of gastric carcinoma.

    Results: The expression rate of HER2 protein was 39. Read More

    Plasma 3,3',5-Triiodo-L-thyronine [T3] level mirrors changes in tumor markers in two cases of metastatic cancer of the breast and pancreas treated with exogenous L-T3.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Clinical Research Unit, ConsorciSanitari del Garraf, Vilanova i la Geltrú, Spain.
    Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine). Read More

    Utility of paraneoplastic antigens as biomarkers for surveillance and prediction of recurrence in ovarian cancer.
    Cancer Biomark 2017 Dec;20(4):369-387
    Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
    Background: Ovarian cancer is frequently diagnosed at an advanced stage and 70% of patients experience recurrence months to years from initial diagnosis. The expression of paraneoplastic antigens can result in the occurrence of onconeural autoantibodies in ovarian cancer that may be associated with neurological disorders that are clinically manifested in patients before diagnosis of ovarian cancer. These paraneoplastic antigens can serve as excellent biomarkers not only for early detection but also for monitoring ovarian cancer recurrence. Read More

    MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
    Cancer Biomark 2017 Nov 3. Epub 2017 Nov 3.
    Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Yunnan, China.
    MicroRNAs are a class of small non-coding RNA molecules that play crucial roles in the initiation and progression of lung cancer. This study was undertaken to investigate the expression and roles of miR-186 in lung cancer. Ectopic expression experiments demonstrated that miR-186 functions as a tumor suppressor. Read More

    Adrenalectomy was recommended for patients with subclinical Cushing's syndrome due to adrenal incidentaloma.
    Cancer Biomark 2017 Oct 31. Epub 2017 Oct 31.
    Objective: To assess whether adrenalectomy may improve biochemical and metabolic impairment for patients with subclinical Cushing syndrome (SCS) due to adrenal incidentaloma (AI) compared with conservative management.

    Methods: A total of 87 patients with SCS due to AI in Peking Union Medical College Hospital between September 2011 and January 2016 have been treated. Forty-eight patients underwent laparoscopic adrenalectomy (operative group), whereas 39 were managed conservatively (control group). Read More

    miR-30a-5p together with miR-210-3p as a promising biomarker for non-small cell lung cancer: A preliminary study.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Medical Biochemistry, Faculty of Health Sciences with the Division of Nursing and Midwifery, Medical University of Lodz, Lodz, Poland.
    Background: Although an immense effort has been made to develop novel diagnostic methods and treatment strategies for non-small cell lung cancer (NSCLC), the survival rate of this disease has remained virtually unchanged. Small non-coding RNAs called microRNAs (miRNAs) have appeared to be very promising biomarkers of cancer including NSCLC.

    Objective: We investigated the expression level of six miRNAs, and subsequently we evaluated their diagnostic ability and their clinical significance. Read More

    Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
    Cancer Biomark 2017 Oct 27. Epub 2017 Oct 27.
    Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
    Objective: To evaluate the correlation of katanin P60 expression with clinicopathological grade and overall survival (OS) in patients with breast cancer (BC).

    Methods: Three hundred and four operative BC patients were retrospectively reviewed in this cohort study. Tumor tissue sample was acquired from each patient during surgery. Read More

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