1,170 results match your criteria Cancer Biomarkers [Journal]


Upregulation of miR-183-5p predicts worse survival in patients with renal cell cancer after surgery.

Cancer Biomark 2019 Jan 15. Epub 2019 Jan 15.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China.

Objective: Renal cell carcinoma (RCC) is one of the most common genitourinary cancers, and advanced RCC usually leads to poor prognosis. Therefore, identifying novel biomarkers for predicting the progression and prognosis of RCC is essential. The present study aims to evaluate the clinical value of miR-183-5p in RCC development and prognosis after surgery. Read More

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http://dx.doi.org/10.3233/CBM-182047DOI Listing
January 2019
1 Read

Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer.

Cancer Biomark 2019 Jan 15. Epub 2019 Jan 15.

Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Circular RNAs (circRNA) play key regulatory roles in cancer progression. Human circRNA microarray was performed to screen for abnormally expressed circRNA in gastric cancer tissues. In this study, we found circRNA102958 was up-regulated in gastric cancer tissues and cell lines. Read More

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http://dx.doi.org/10.3233/CBM-182029DOI Listing
January 2019

Identification of biomarkers associated with progression and prognosis in bladder cancer via co-expression analysis.

Cancer Biomark 2019 Jan 18. Epub 2019 Jan 18.

Background: Bladder cancer is one of the most common genitourinary malignancies, with a high rate of recurrence and progression. The prognosis for patients with bladder cancer, especially muscle-invasive bladder cancer, remains poor despite systemic therapy.

Objective: To explore the underlying disease mechanisms and identify more effective biomarkers for bladder cancer. Read More

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http://dx.doi.org/10.3233/CBM-181940DOI Listing
January 2019

Esculetin enhances the inhibitory effect of 5-Fluorouracil on the proliferation, migration and epithelial-mesenchymal transition of colorectal cancer.

Cancer Biomark 2019 Jan 18. Epub 2019 Jan 18.

Department of Oncology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China.

Background: Colorectal cancer (CRC) is the most common malignant disease worldwide and thus new therapeutic approaches are needed. 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Read More

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http://dx.doi.org/10.3233/CBM-181764DOI Listing
January 2019
1 Read

RASSF1A and SOCS1 genes methylation status as a noninvasive marker for hepatocellular carcinoma.

Cancer Biomark 2019 Jan 14. Epub 2019 Jan 14.

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: DNA methylation status is one of the most prevalent molecular alterations in human cancers. Identification of powerful diagnostic and prognostic biomarkers for hepatocellular carcinoma (HCC) without a biopsy is urgently required.

Objective: The purpose of this study was to determine the methylation status of RASSIF1A and SOCS-1genes as a non-invasive biomarker for HCC identification and prognosis. Read More

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http://dx.doi.org/10.3233/CBM-181638DOI Listing
January 2019

Potential diagnostic and prognostic value of plasma long noncoding RNA LINC00086 and miR-214 expression in gastric cancer.

Cancer Biomark 2019 Jan 14. Epub 2019 Jan 14.

People's Hospital of Hengshui City, Hengshui, Hebei, China.

Background: Plasma carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4) are common markers which are useful in the diagnosis and prognosis of GC. However, their sensitivity and specificity in GC remain unsatisfactory. Identification of cancer diagnosed-biomarkers would be of great value. Read More

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http://dx.doi.org/10.3233/CBM-181486DOI Listing
January 2019

The association of Bcl-xL and p53 expression with survival outcomes in oropharyngeal cancer.

Cancer Biomark 2018 Dec 27. Epub 2018 Dec 27.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Background: The role of molecular biomarkers in oropharyngeal squamous cell carcinoma (OPSCC) has recently been increasingly recognized. There is conflicting evidence in the literature with regards to the prognostic value of p53 and Bcl-xL.

Objective: The purpose of this study was to investigate the association between p53 and Bcl-xL expression profiles and survival outcomes in OPSCC. Read More

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http://dx.doi.org/10.3233/CBM-182106DOI Listing
December 2018
5 Reads

MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer.

Cancer Biomark 2018 Dec 27. Epub 2018 Dec 27.

Background: A growing body of studies has demonstrated the aberrant expression of microRNAs (miRNAs) contributes to human tumor metastasis. MicroRNA-124-3p (miR-124-3p), which is down-regulated in various cancers, has been found to be involved in several signaling pathways relevant to tumor cell migration and invasion. However, the roles of miR-124-3p in human bladder cancer remain unclear. Read More

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http://dx.doi.org/10.3233/CBM-182000DOI Listing
December 2018
6 Reads

The therapeutic role of inhibition of miR-328 on pulmonary carcinoma induced by chlamydia pneumoniae through targeting histone H2AX.

Cancer Biomark 2018 Dec 27. Epub 2018 Dec 27.

Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.

Lung cancer represents a major healthy concern due to high incidence and morality. Increasing evidences showed critical regulatory role of microRNA (miR) in cell growth, differentiation and apoptosis. It has been indicated that the level of miR-328 is abnormally up regulated in lung cancer cell line, which is correlated with cell apoptosis. Read More

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http://dx.doi.org/10.3233/CBM-181999DOI Listing
December 2018
6 Reads

MicroRNA-18a promotes proliferation and metastasis in oral squamous cell carcinoma via targeting KLF4.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Oral squamous cell carcinoma (OSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to explore the regulatory mechanism of microRNA-18a in OSCC cells proliferation and metastasis. Quantitative real-time PCR (qRT-PCR) was used to detect the expression level of miR-18a and KLF4 mRNA in OSCC tissues and cell lines (SCC-25, CAL-27, Tca-8113). Read More

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http://dx.doi.org/10.3233/CBM-181943DOI Listing
December 2018
7 Reads

Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Hematology, Gansu Provincial Hospital, Lanzhou, Gansu, China.

Objective: Human multiple myeloma (MM) is a kind of common tumor in middle-aged and elderly people, in which the osteolytic lesion is formed mainly through inhibiting osteoblast (OB) differentiation and promoting osteoclast (OC) differentiation. Dickkopf-1 (DKK1) is a soluble Wnt inhibitor, which has an important correlation with the pathogenesis of human MM. Therefore, the correlations of DKK1 with pathogenesis and prognosis of human MM were investigated in this study. Read More

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http://dx.doi.org/10.3233/CBM-181909DOI Listing
December 2018
6 Reads

Modulation on gallbladder carcinoma by TGF-β1 via IGFBP-2.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China.

Gallbladder carcinoma (GC) occupies more than 90% of all cancers in biliary tract with an increasing incidence. Most patients with GC are already at terminal stage at the time of primary diagnosis, causing unfavorable prognosis and high mortality. Transformation growth factor-beta (TGF-β) is up-regulated in GC. Read More

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http://dx.doi.org/10.3233/CBM-181895DOI Listing
December 2018
7 Reads
1.186 Impact Factor

Downregulation of the expression of the lncRNA MIAT inhibits melanoma migration and invasion through the PI3K/AKT signaling pathway.

Cancer Biomark 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.

Background: Long noncoding RNA MIAT expression is related to the development of some diseases. However, the role of MIAT in melanoma was has seldom been studied.

Objective: To investigate the effect of the lncRNA MIAT on melanoma cells. Read More

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http://dx.doi.org/10.3233/CBM-181869DOI Listing
December 2018
2 Reads
1.186 Impact Factor

Expression and clinical significance of Transcription factor 4 (TCF4) in epithelial ovarian cancer.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.

Objectives: To investigate TCF4 expression in epithelial ovarian cancer, and to explore its correlation with clinicopathological parameters and clinical prognosis of epithelial ovarian cancer.

Methods: From 2009 to 2017, 188 cases of paraffin-embedded epithelial ovarian cancer tissues and 41 paratumor ovarian tissues which had been confirmed at the memorial hospital of Sun Yat-sen University were collected in this study, and the expression of TCF4 was performed by immunohistochemistry using a polyclonal antibody specific for TCF4.

Results: The expression of TCF4 protein was associated with disease progression free survival and overall survival in epithelial ovarian cancer patients; and TCF4 overexpression was associated with age, FIGO stage, lymph node metastasis, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence, and serum CA153. Read More

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http://dx.doi.org/10.3233/CBM-181849DOI Listing
December 2018
10 Reads

Gene expression profiling identifies potential molecular markers of papillary thyroid carcinoma.

Cancer Biomark 2018 Dec 22. Epub 2018 Dec 22.

Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA.

Background: Thyroid cancer is the most common endocrine malignancy worldwide, with the predominant form papillary thyroid carcinoma (PTC) representing approximately 80% of cases.

Objective: This study was addressed to identify potential genes and pathways involved in the pathogenesis of PTC and potential novel biomarkers for this disease.

Methods: Gene expression profiling was carried out by DNA microarray technology. Read More

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http://dx.doi.org/10.3233/CBM-181758DOI Listing
December 2018
7 Reads

The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer.

Cancer Biomark 2018 Dec 25. Epub 2018 Dec 25.

High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, China.

Background: Cisplatin-based chemotherapy and radiotherapy are the most commonly used treatments for small cell lung cancer (SCLC). However, despise initially dramatic response, the response duration of SCLC patients is variable and resistance to chemo- and radio-therapy inevitably develops.

Objective: The aim of the study is to investigate the role of Bcl-2 family proteins in predicting SCLC sensitivity to cisplatin treatment, and to identify the potential sensitizer of cisplatin or ratiation treatment in SCLC. Read More

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http://dx.doi.org/10.3233/CBM-181692DOI Listing
December 2018
1 Read

MiR-27a promotes EMT in ovarian cancer through active Wnt/𝜷-catenin signalling by targeting FOXO1.

Cancer Biomark 2018 Nov 26. Epub 2018 Nov 26.

Department of Gynecology, Huizhou No. 2 Women's and Children's Healthcare Hospital, Huizhou, Guangdong 516001, China.

Background: Ovarian cancer (OC) is the fifth most common type of cancer in women worldwide. MiR-27a plays an important role in the development of ovarian cancer. However, the exact function and molecular mechanism of miR-27a in epithelial-mesenchymal transition (EMT) has not been thoroughly elucidated to date. Read More

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http://dx.doi.org/10.3233/CBM-181229DOI Listing
November 2018
3 Reads

Frameshift mutation of candidate tumor suppressor genes QK1 and TMEFF2 in gastric and colorectal cancers.

Cancer Biomark 2018 Dec 25. Epub 2018 Dec 25.

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Both QKI and TMEFF2 genes are considered putative tumor suppressor genes (TSGs). In gastric (GC) and colorectal (CRC) cancers, downregulation of their expressions is known to be frequent. However, QKI and TMEFF2 mutations that could potentially inactivate their functions are not reported in cancers. Read More

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http://dx.doi.org/10.3233/CBM-160559DOI Listing
December 2018
1 Read

miR-378 serves as a prognostic biomarker in cholangiocarcinoma and promotes tumor proliferation, migration, and invasion.

Cancer Biomark 2018 Dec 19. Epub 2018 Dec 19.

MicroRNAs (miRNAs) have been demonstrated that play a critical role in tumorigenesis. The aim of this study is to identify the functional role of miR-378 in cholangiocarcinoma (CCA). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression levels of miR-378 in human CCA tissue samples and CCA cell lines. Read More

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http://dx.doi.org/10.3233/CBM-181980DOI Listing
December 2018
1 Read

ADP-ribosylation factor-like 4C predicts worse prognosis in endometriosis-associated ovarian cancers.

Cancer Biomark 2018 Dec 19. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520 2192, Japan.

Background: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancer (EAOC). Despite the high rates of recurrence and mortality of EAOC, no prognostic biomarkers have been determined. ADP-ribosylation factor-like protein 4C (ARL4C) has been reported to be involved in various tumor progression processes, but its clinical significance for predicting prognosis in EAOC cases has never been studied. Read More

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http://dx.doi.org/10.3233/CBM-181836DOI Listing
December 2018
2 Reads

The altered expression levels of miR-186, miR-494 and miR-3651 in OSCC tissue vary from those of the whole blood of OSCC patients.

Cancer Biomark 2018 Dec 18. Epub 2018 Dec 18.

Department of Oral and Maxillofacial Surgery, Medical University of Vienna, Vienna 1090, Austria.

Background: Altered expressions of miR-186, miR-494 and miR-3651 in whole blood of OSCC patients have already been demonstrated. However, nothing is known about their expression in tumor tissues. This study aimed at evaluating differences in miRNA expression in OSCC tissues compared to healthy oral mucosa and at checking if the altered expression is reflected in corresponding blood. Read More

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http://dx.doi.org/10.3233/CBM-180032DOI Listing
December 2018
1 Read

Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma.

Cancer Biomark 2018 Dec 14. Epub 2018 Dec 14.

Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Background: The significance of serum dipeptidyl peptidase-IV (DPP-IV) in papillary thyroid carcinoma (PTC) has not been elucidated.

Objective: This study aimed to assess the role of serum DPP-IV in the carcinogenesis and prognosis of PTC.

Methods: The serum DPP-IV concentration was measured in 171 male patients with PTC, 81 male patients with a benign thyroid nodule (BTN), and 52 male healthy controls (HCs). Read More

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http://dx.doi.org/10.3233/CBM-170908DOI Listing
December 2018
3 Reads

Metabolo-volumetric parameters of 18F-FDG-PET can predict expression of EGFR and HIF 1alpha in uterine cervical cancer.

Cancer Biomark 2018 Nov 26. Epub 2018 Nov 26.

Department of Nuclear Medicine, University Hospital of Leipzig, Leipzig 04103, Germany.

Background: The aim of our study was to investigate possible relationships between 18F-FDG-PET parameters and clinically relevant histopathological findings in patients with cervical cancer (CC).

Methods: Eighteen female patients (mean age 55.4 years) with histologically confirmed squamous cell CC were involved into the study. Read More

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http://dx.doi.org/10.3233/CBM-182019DOI Listing
November 2018
2 Reads

MicroRNA-539 inhibits the progression of Wilms' Tumor through downregulation of JAG1 and Notch1/3.

Cancer Biomark 2018 Nov 26. Epub 2018 Nov 26.

Department of Blood Transfusion, Yankuang Group General Hospital, Zoucheng, Shandong, China.

Background: Previous studies demonstrated that miR-539 play an important role in the carcinogenesis of some cancers. The aim of the present study was to determine the role of miR-539 in the pathogenesis of Wilms' Tumor (WT).

Methods: The expression level of miR-539 was measured by qRT-PCR in 42 WT tissues and SK-NEP-1 cell line. Read More

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http://dx.doi.org/10.3233/CBM-181972DOI Listing
November 2018
8 Reads

Serum miR-100 is a potential biomarker for detection and outcome prediction of glioblastoma patients.

Cancer Biomark 2018 Nov 26. Epub 2018 Nov 26.

College of Physical Education, Yan'an University, Yan'an, Shaanxi 716000, China.

Background: It is well known that some circulating microRNAs (miRNAs) are highly stable and might serve as promising biomarkers for many types of human cancer including glioblastoma (GBM). However, the potential clinical significance of serum miR-100 in GBM remained unknown.

Objective: We aimed to detect the expression level of serum miR-100 in patients with GBM and assess its potential diagnostic and prognostic value. Read More

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http://dx.doi.org/10.3233/CBM-181416DOI Listing
November 2018
2 Reads

Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk.

Cancer Biomark 2018 Nov 12. Epub 2018 Nov 12.

Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Long non-coding RNAs (lncRNAs) are emerging as candidate biomarkers of cancer, having regulatory functions in both oncogenic and tumor-suppressive pathways. Concerning pancreatic cancer (PC), deregulation of lncRNAs involved in tumor initiation, invasion, and metastasis seem to play a key role. However, data is scarce about regulatory mechanism of lncRNA expression. Read More

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http://dx.doi.org/10.3233/CBM-181959DOI Listing
November 2018
18 Reads

Targeted regulation by ROCK2 on bladder carcinoma via Wnt signaling under hypoxia.

Cancer Biomark 2018 Nov 11. Epub 2018 Nov 11.

Bladder cancer is frequently occurred in urinary system and has complicated pathogenesis factors including both genetics and environmental factors that have not been fully illustrated. Hypoxia can further induce tumor progression. ROCK2 has abnormal expression in various tumors but its expression or functional role in bladder cancer have not been illustrated. Read More

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http://dx.doi.org/10.3233/CBM-181949DOI Listing
November 2018
9 Reads

α2δ1 may be a potential marker for tumor stem cell in laryngeal squamous cell carcinoma.

Cancer Biomark 2018 Nov 10. Epub 2018 Nov 10.

Department of Otolaryngology and Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Cancer stem cells (CSCs) have the ability to dictate tumor initiation, recurrence, and metastasis. Here, we examined the expression of aα2δ1+ in laryngeal cancer tissues and further determined the effect of α2δ1 on the migratory ability and tumorigenicity of laryngeal cancer cells. Immunofluorescence staining revealed that α2δ1 was positive in 13 (13/16, 81. Read More

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http://dx.doi.org/10.3233/CBM-181947DOI Listing
November 2018
6 Reads
1.186 Impact Factor

TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.

Cancer Biomark 2018 Nov 10. Epub 2018 Nov 10.

Department of Urology, School of Medicine, Kitasato University, Sagamihara 2520374, Japan.

Background: New biomarkers may help us provide individualized prognosis and allow risk-stratified clinical decision making about radical treatment.

Objectives: This study aimed to determine the tumor necrosis factor of receptor superfamily 19 (TROY) expression in urothelial carcinoma and its relationship to clinicopathological findings.

Methods: Immunohistochemical staining for TROY was carried out in 136 archival radical cystectomy specimens with immunoreactivity being stratified on a 0-9 scale. Read More

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http://dx.doi.org/10.3233/CBM-181911DOI Listing
November 2018
2 Reads

Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.

Cancer Biomark 2018 ;23(4):589-601

Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.

Objective: Osteosarcoma is the most common primary malignant skeleton tumor that derives from mesenchymal cells. Emerging evidences have identified the vital role of long non-coding RNAs (lncRNAs) in the development of osteosarcoma. In this study, we aimed to investigate the role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in osteosarcoma progression. Read More

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http://dx.doi.org/10.3233/CBM-181863DOI Listing
January 2018
10 Reads

Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection.

Cancer Biomark 2018 ;23(4):579-587

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, Chongqing 400030, China.

Background: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.

Materials And Methods: Relative public microarray data were obtained and analyzed for screening of the plasma differentially expressed miRNAs (DEMs) between NPC patients and controls. Read More

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http://dx.doi.org/10.3233/CBM-181852DOI Listing
January 2018
4 Reads

Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway.

Cancer Biomark 2018 ;23(4):603-613

Background: Small nucleolar RNA host gene 12 (SNHG12) has been shown to be a long noncoding RNA (lncRNA) that facilitates the progression of a number of malignancies. However, the expression pattern and biological function of SNHG12 in nasopharyngeal carcinoma (NPC) have not been investigated.

Objective: The aim of our study is to investigate the expression, clinical significance and function of SNHG12 in NPC. Read More

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http://dx.doi.org/10.3233/CBM-181873DOI Listing
January 2018
15 Reads

Correlation of long non-coding RNA taurine-upregulated gene 1 with disease conditions and prognosis, as well as its effect on cell activities in acute myeloid leukemia.

Cancer Biomark 2018 ;23(4):569-577

Objective: This study aimed to investigate the correlation of long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) with clinicopathological characteristics and prognosis in acute myeloid leukemia (AML) patients, as well as its function in cell proliferation and apoptosis.

Methods: Two hundred and thirty six de novo AML patients were consecutively enrolled and then underwent conventional induction chemotherapy. Bone marrow samples were obtained from all AML patients and controls. Read More

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http://dx.doi.org/10.3233/CBM-181834DOI Listing
January 2018
10 Reads

Long noncoding RNA HOTTIP is a significant indicator of ovarian cancer prognosis and enhances cell proliferation and invasion.

Cancer Biomark 2018 Nov 7. Epub 2018 Nov 7.

Long noncoding RNAs (LncRNAs) are involved in the occurrence and progression of human tumors including ovarian cancer (OC). Long noncoding RNA HOTTIP has been found to be involved in several human tumors development. However, the role of HOTTIP in OC remains large unknown. Read More

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http://dx.doi.org/10.3233/CBM-181727DOI Listing
November 2018
12 Reads

Comprehensive analysis of aberrantly expressed profiles of lncRNAs, miRNAs and mRNAs with associated ceRNA network in cholangiocarcinoma.

Cancer Biomark 2018 ;23(4):549-559

Department of General Surgery, Anhui Provincial Hospital, Hefei, Anhui, China.

Cholangiocarcinoma (CCA) is a highly malignant and poorly differentiated bile duct cancer with an extremely poor prognosis, but the pathogenesis of CCA remains not well-known. Attention has been increasingly focused on long noncoding RNAs, which plays an important role in tumorigenesis. However, the roles of cancer specific lncRNA and its related competitive endogenous RNAs (ceRNA) network in CCA remain elusive. Read More

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http://dx.doi.org/10.3233/CBM-181684DOI Listing
January 2018
3 Reads

High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort.

Cancer Biomark 2018 ;23(4):539-547

3rd Department of Internal Medicine, Semmelweis University, Budapest 1125, Hungary.

Background: Hsp70 plays important role in the development and progression of cancer. Previously we described the association between serum Hsp70 levels and mortality of colorectal cancer.

Objective: In this new prospective study we aimed to confirm and extend our previous findings in a larger cohort of patients, based on a longer follow-up period. Read More

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http://dx.doi.org/10.3233/CBM-181683DOI Listing
January 2018
7 Reads

MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.

Cancer Biomark 2018 ;23(4):515-525

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Objective: Renal cancer accounts for about 3% of human cancer, and clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Recently, microRNAs (miRNAs) are found to be the biomarkers for cancer diagnosis, prognosis and the targets for tumor management. This study aimed to examine the expression of miR-337-3p in ccRCC and to elucidate the molecular mechanisms underlying miR-337-3p-mediated ccRCC progression. Read More

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http://dx.doi.org/10.3233/CBM-181645DOI Listing
January 2018
11 Reads

Correlation of circulating pro-angiogenic miRNAs with cardiotoxicity induced by epirubicin/cyclophosphamide followed by docetaxel in patients with breast cancer.

Cancer Biomark 2018 ;23(4):473-484

Department of General Surgery, The Second People's Hospital of Liaocheng, Linqing, Shandong, China.

Objective: This study aimed to evaluate predictive value of 14 pro-angiogenic miRNAs for cardiotoxicity induced by epirubicin/cyclophosphamide follow by docetaxel (EC-D) in breast cancer (BC) patients.

Methods: Three hundred and sixty-three BC patients receiving EC-D neoadjuvant chemotherapy were consecutively enrolled in this prospective cohort study. Peripheral blood sample was obtained from each patient, and plasma was separated. Read More

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http://dx.doi.org/10.3233/CBM-181301DOI Listing
January 2018
8 Reads

Analysis of clinical characteristics of bone marrow proliferative tumor progression to acute myeloid leukemia.

Cancer Biomark 2018 ;23(4):469-472

Objective: This study aims to analyze Chinese patients who developed acute leukemia after being diagnosed and treated for Philadelphia chromosome (Ph)-negative chronic myeloproliferative neoplasms (MPNs), and compare the findings of this series with similar studies from literature.

Methods: Nine patients who progressed to leukemia after being diagnosed with MPN were included into the present study. Clinical data including age, treatment modalities and duration of use in the myeloproliferative phase, latency to leukemic transformation (LT), characteristics of leukemia, chemotherapy administration, and survival after LT were examined. Read More

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http://dx.doi.org/10.3233/CBM-171145DOI Listing
January 2018
3 Reads

Erratum.

Authors:

Cancer Biomark 2018 ;23(2):311

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http://dx.doi.org/10.3233/CBM-179577DOI Listing
January 2018
1 Read

Notice of Retraction.

Authors:

Cancer Biomark 2018 ;23(2):313

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http://dx.doi.org/10.3233/CBM-179249DOI Listing
January 2018
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The effect of high intensity focused ultrasound on the treatment of liver cancer and patients' immunity.

Cancer Biomark 2018 Oct 9. Epub 2018 Oct 9.

Department of Functional Examination, The Sixth People's Hospital of Qingdao, Qingdao 266033, Shandong, China.

Objective: To investigate the effects of high intensity focused ultrasound on liver function, tumor markers and survival rate of hepatocellular carcinoma patients.

Methods: Ninety six cases with primary liver cancer patients, consisting of 66 males and 30 females, were enrolled in this study and treated with high intensity focused ultrasound combined with stereotactic segmentation dose radiation, low frequency for 10 times, followed by analysis of KPS score of liver cancer, Child-Pugh, grading and staging of liver cancer, 3 months, 6 months, 1 year of clinical symptom remission rate, tumor markers, liver function, survival rate, as well as the change of immune related cytokines.

Results: Three months after high intensity focused ultrasound treatment, abdominal distension abdominal pain, jaundice symptoms, anorexia and ascites were significantly relieved compared with before treatment (P< 0. Read More

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http://dx.doi.org/10.3233/CBM-181822DOI Listing
October 2018
9 Reads

The diagnostic effect of serum miR-139-5p as an indicator in osteosarcoma.

Cancer Biomark 2018 ;23(4):561-567

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Background: The microRNA, miR-139-5p, plays an important role in the initiation and progression of various tumor types including osteosarcoma (OS).

Objective: This study aimed to detect the serum miR-139-5p expression in OS and analyze its association with clinical variables.

Methods: Blood samples were taken from 98 OS patients and 50 healthy individuals, and serum miR-139-5p levels were measured by quantitative reverse transcription-polymerase chain reaction. Read More

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http://dx.doi.org/10.3233/CBM-181744DOI Listing
January 2018
8 Reads

NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/β-catenin signaling pathway and predicts good prognosis.

Cancer Biomark 2018 Oct 9. Epub 2018 Oct 9.

Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China.

Background: Nucleoporin NUP153 (NUP153) is well known to be involved in the regulating of nuclear transport. Although NUP153 is associated with several cancers, its role in colorectal cancer (CRC) and the underlying mechanism are still unknown.

Objective: The aim of this study was to access the effect of NUP153 on the prognosis of patients with CRC, and cancer cell proliferation. Read More

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http://dx.doi.org/10.3233/CBM-181703DOI Listing
October 2018
13 Reads

AnnexinA7 down-regulation might suppress the proliferation and metastasis of human hepatocellular carcinoma cells via MAPK/ ERK pathway.

Cancer Biomark 2018 ;23(4):527-537

Histology and Embryology Department, Chengde Medical University, Chengde 067000, Hebei, China.

Background: Hepatocellular carcinoma is one of the most fatal malignancies worldwide with high lethality. However, the exact mechanism of liver tumorigenesis is still unclear. AnnexinA7 (ANXA7) is a Ca2+-binding protein which is involved in membrane organization and dynamics and indicated a role of ANXA7 in cancer. Read More

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http://dx.doi.org/10.3233/CBM-181651DOI Listing
January 2018
9 Reads

Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged overall survival, and it inhibits cells proliferation while promotes cells apoptosis in epithelial ovarian cancer.

Cancer Biomark 2018 ;23(4):505-513

Department of Histology and Embryology, Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.

Objective: The aim of this study was to evaluate the correlation of circular RNA itchy E3 ubiquitin protein ligase (Circ-ITCH) expression with clinicopathological features and survival in patients with epithelial ovarian cancer (EOC), and to explore its effect on cells proliferation as well as apoptosis in EOC cells.

Methods: Seventy-seven EOC patients underwent surgery were retrospectively reviewed. Tumor tissues and paired adjacent tissues samples were collected, and Circ-ITCH expression was evaluated by quantitative polymerase chain reaction (qPCR). Read More

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http://dx.doi.org/10.3233/CBM-181609DOI Listing
January 2018
5 Reads

CD45 correlates with adverse risk stratification, decreased treatment response and unfavorable survival profiles in elderly acute myeloid leukemia patients.

Cancer Biomark 2018 ;23(3):455-463

Objective: This study aimed to explore the correlation of CD45 expression with clinicopathological features and treatment outcomes in elderly acute myeloid leukemia (AML) patients.

Methods: One hundred and twenty one elderly patients with de novo AML were consecutively recruited in this prospective cohort study, bone marrow samples from all patients were collected and CD45 expression were measured with flow cytometry. Complete remission (CR), event-free survival (EFS) and overall survival (OS) were evaluated. Read More

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http://dx.doi.org/10.3233/CBM-181602DOI Listing
January 2018
11 Reads

Downregulation of long noncoding RNA PVT1 attenuates paclitaxel resistance in glioma cells.

Cancer Biomark 2018 ;23(3):447-453

Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.

Background: Drug resistance in clinical cancer treatment has become an issue.

Objective: We focus on abnormally expressed lncRNAs in glioma and investigating the function of PVT1.

Methods: The paclitaxel-resistant glioma cells SHG-44 RE was obtained through screening the SHG 44 cells that were cultured in medium containing a certain concentration of paclitaxel. Read More

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http://dx.doi.org/10.3233/CBM-181573DOI Listing
January 2018
8 Reads

Identification of crucial genes and prediction of small molecules for multidrug resistance of Hodgkin's lymphomas.

Cancer Biomark 2018 ;23(4):495-503

Department of Internal Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Background: Multidrug resistance of Hodgkin's lymphoma (HL) often results in recurrence. Thus, we aimed to explore the underlying molecular mechanisms of multidrug resistance using bioinformatics strategies.

Methods: The gene expression profile was obtained from GEO database. Read More

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http://dx.doi.org/10.3233/CBM-181496DOI Listing
January 2018
3 Reads

Long non-coding RNA taurine-upregulated gene 1 correlates with unfavorable prognosis in patients with refractory or relapsed acute myeloid leukemia treated by purine analogue based chemotherapy regimens.

Cancer Biomark 2018 ;23(4):485-494

Objective: This study aimed to explore the correlation of long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) expression with clinicopathological features and its predictive value for treatment response and survival profiles in refractory or relapsed acute myeloid leukemia (R/R AML) patients.

Methods: Seventy three R/R AML patients who received cladribine combined with cytarabine and granulocyte colony-stimulating factor (G-CSF) (CLAG) or fludarabine combined with cytarabine and G-CSF (FLAG) based chemotherapy and 37 non-malignant controls were recruited. LncRNA TUG1 expression was detected in bone marrow sample obtained before treatment. Read More

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http://dx.doi.org/10.3233/CBM-181405DOI Listing
January 2018
10 Reads