1,201 results match your criteria Cancer Biomarkers [Journal]


DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.

Cancer Biomark 2019 Apr 4. Epub 2019 Apr 4.

Institute of Hematology and Blood Transfusion, Prague, Czech Republic.

Background: Aberrant epigenetic patterns are a hallmark of acute myeloid leukemia (AML). Mutations in profound epigenetic regulators DNMT3A and IDH1/2 often occur concurrently in AML.

Objectives: The aim was to analyze DNA methylation, hydroxymethylation and mRNA expression profiles in AML with mutations in DNMT3A and IDH1/2 (individually and in combinations). Read More

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http://dx.doi.org/10.3233/CBM-182176DOI Listing

Platelet indices in non-small cell lung cancer patients with brain metastases.

Cancer Biomark 2019 Mar 14. Epub 2019 Mar 14.

Institute of Intensive Care Unit, Heilongjiang Academy of Medical Science, Harbin, Heilongjiang 150081, China.

Background: Platelets play a crucial role in cancer progression and metastasis. The aim of the present study was to assess the relationship between platelet indices and non-small cell lung cancer (NSCLC) with brain metastases.

Methods: Between January 2015 and December 2017, 232 NSCLC patients with brain metastases and 244 NSCLC patients without metastases were retrospectively analyzed. Read More

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http://dx.doi.org/10.3233/CBM-192393DOI Listing
March 2019
1 Read

Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer.

Cancer Biomark 2019 Mar 22. Epub 2019 Mar 22.

Department of Surgery, College of Medicine, Soonchunhyang University, Chungcheongnam-do, 330-723, Korea.

Defensin alpha 6 (DEFA6) is a member of the alpha defensin family of microbicidal and cytotoxic peptides that defend against bacteria and viruses. Here, we provide a novel function of DEFA6 in tumorigenesis of colorectal cancer (CRC) in vitro and in vivo. Specifically, DEFA6 is highly expressed in both CRC cancer cell lines as well as patient-derived samples at the level of RNA and protein. Read More

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http://dx.doi.org/10.3233/CBM-182221DOI Listing

Relationship between p-cofilin and cisplatin resistance in patients with ovarian cancer and the role of p-cofilin in prognosis.

Cancer Biomark 2019 Mar 22. Epub 2019 Mar 22.

Objective: This study aims to determine the correlation between p-cofilin expression and cisplatin resistance in patients with ovarian cancer, and also to investigate the role of p-cofilin in prognosis.

Patients And Methods: The ovarian cancer cell line A2780/DDP resistant to cisplatin was prepared. The cell resistance to cisplatin was measured via MTT assay. Read More

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http://dx.doi.org/10.3233/CBM-182209DOI Listing
March 2019
1 Read

Expression and clinical significance of serum NT5E protein in patients with colorectal cancer.

Cancer Biomark 2019 Mar 22. Epub 2019 Mar 22.

Department of Colorectal Surgery, Zhejiang Cancer Hospital, Zhejiang, China.

Objective: This study aimed to investigate the expression level and clinical significance of serum NT5E protein (ecto-5'-nucleotidase) in patients with colorectal cancer.

Methods: The expression level of serum NT5E protein in 232 patients with colorectal cancer and 158 normal controls was detected using enzyme-linked immunosorbent assay. Moreover, the relationship between the expression level of serum NT5E and the clinicopathological features of colorectal cancer was analyzed. Read More

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http://dx.doi.org/10.3233/CBM-182207DOI Listing

Low absolute NK cell counts in peripheral blood are associated with inferior survival in patients with mantle cell lymphoma.

Cancer Biomark 2019 Mar 22. Epub 2019 Mar 22.

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, China.

Background: Although risk stratification of mantle cell lymphoma (MCL) is most frequently performed using the simplified MCL International Prognostic Index (sMIPI), the identification of host-related factors and tumor microenvironment, including absolute monocyte counts (AMC) and peripheral blood T lymphocyte subsets, especially absolute natural killer cell counts (ANKC) has been suggested to be critical in the prediction of prognosis and the guidance of treatment.

Objective: This study was aimed at investigating whether peripheral blood ANKC and AMC at diagnosis had an impact on MCL prognosis.

Methods: A total of 92 newly diagnosed MCL patients was enrolled in this retrospective study. Read More

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http://dx.doi.org/10.3233/CBM-182193DOI Listing
March 2019
1 Read
1.186 Impact Factor

Sub-terahertz vibrational spectroscopy of ovarian cancer and normal control tissue for molecular diagnostic technology.

Cancer Biomark 2019 Mar 8. Epub 2019 Mar 8.

Vibratess LLC, Charlottesville, VA, 22902, USA.

We introduce here recently developed highly resolved Sub-Terahertz resonance spectroscopy of biological molecules and cells combined with molecular dynamics (MD) computational analysis as a new approach for optical visualization and quantification of the presence of microRNAs, particularly the mir-200 family, as potential biomarkers in samples from tissue of epithelial ovarian cancers for disease early detection, analysis, prognosis and treatment.METHOD: A set of samples for this study was prepared from anonymized archival formalin-fixed, paraffin-embedded ovarian epithelial tissue containing regions of invasive neoplastic cells from cases of high-histologic grade serous papillary ovarian carcinoma. Control samples were normal mucosa from fallopian tubes of patients with no known malignancy. Read More

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http://dx.doi.org/10.3233/CBM-182120DOI Listing
March 2019
2 Reads

Erratum.

Authors:

Cancer Biomark 2019 Mar 13. Epub 2019 Mar 13.

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http://dx.doi.org/10.3233/CBM-189863DOI Listing

Circ0001429 regulates progression of bladder cancer through binding miR-205-5p and promoting VEGFA expression.

Cancer Biomark 2019 Mar 12. Epub 2019 Mar 12.

Objective: This study investigates expressions of circ0001429, miR-205-5p and Vascular endothelial growth factor (VEGFA) in bladder cancer tissues and their effects on the proliferation, migration and apoptosis.

Methods: Arraystar Human CircRNA chip was applied to analyzing the differential expression of circRNA in four bladder cancer tissues and paired adjacent normal bladder tissues. Real time quantitative PCR was utilized to detect the expression of circ0001429 in tissue specimens. Read More

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http://dx.doi.org/10.3233/CBM-182380DOI Listing

Clinical significance of the expression of long non-coding RNA PVT1 in glioma.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

Background: Glioma is the most common primary malignant tumor in the nervous system.

Objective: To investigate the expression of long non-coding RNA Pvt1 oncogene (PVT1) in glioma and its clinical significance.

Methods: The expression levels of PVT1 were determined in 59 glioma and 10 normal tissue samples using qRT-PCR. Read More

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http://dx.doi.org/10.3233/CBM-182253DOI Listing
March 2019
2 Reads

Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429.

Cancer Biomark 2019 Mar 12. Epub 2019 Mar 12.

Objective: Schizandrin A (SchA) exerts anticancer potential. However, the effects of SchA on thyroid cancer (TC) have not been clear illuminated. Therefore, we investigated the effects of SchA on TC cell line TPC-1 and the underlying mechanisms. Read More

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http://dx.doi.org/10.3233/CBM-182222DOI Listing
March 2019
11 Reads

Clinical significance of serum miR-25 as a diagnostic and prognostic biomarker in human gastric cancer.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Background And Objective: MicroRNAs (miRNAs) are under investigation as novel diagnostic and prognostic biomarkers in several malignancies, including gastric cancer (GC). miR-25 was overexpressed in GC tissues, and higher miR-25 expression was statistically correlated with aggressive clinicopathological characteristics. In our study, we investigate the associations of serum miR-25 level with the clinicopathological characteristics, diagnosis and prognosis of GC patients. Read More

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http://dx.doi.org/10.3233/CBM-182213DOI Listing
March 2019
3 Reads

SIRT5 downregulation is associated with poor prognosis in glioblastoma.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Objective: Sirtuins (SIRT) are NAD+-dependent protein deacetylases that are involved in the regulation of cancer-associated pathways. However, the biological role of these deacetylases remains elusive in glioblastoma (GBM). Here, we evaluated the effects of 7 sirtuins regarding their occurrence and prognostic value for GBM. Read More

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http://dx.doi.org/10.3233/CBM-182197DOI Listing
March 2019
5 Reads

Downregulation of long noncoding RNA LINC00460 expression suppresses tumor growth in vitro and in vivo in gastric cancer.

Cancer Biomark 2019 Mar 8. Epub 2019 Mar 8.

Department of Respiratory Medicine, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei 430060, China.

Background: Long noncoding RNA have been indicated to be involved in tumor development. However, the role of LINC00460 in gastric cancer (GC) still remains large unknown. The current study is designed aiming at determining the effects of LINC00460 on GC progression. Read More

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http://dx.doi.org/10.3233/CBM-182177DOI Listing
March 2019
1 Read

Upregulation of lncRNA AB073614 functions as a predictor of epithelial ovarian cancer prognosis and promotes tumor growth in vitro and in vivo.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, China.

Backgrounds: Upregulation of lncRNA AB073614 is found in some cancer types and involved in tumor development and progression including ovarian cancer. However, the clinical value and functional role of lncRNA AB073614 in epithelial ovarian cancer (EOC) still needed to be investigated.

Methods: We examined lncRNA AB073614 expression using quantitative real time polymerase chain reaction (qRT-PCR) in 75 paired of EOC tissue samples and adjacent normal tissues. Read More

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http://dx.doi.org/10.3233/CBM-182160DOI Listing
March 2019
1 Read

Ginsenoside impedes proliferation and induces apoptosis of human osteosarcoma cells by down-regulating β-catenin.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

Background: Osteosarcoma (OS) is the most commonly occurred primary bone malignancy with high incident rates among children and adolescents. In pharmacologic treatment, the drug ginsenoside has been shown to exert anticancer effects on several malignant diseases. The purpose of this research was to investigate the effect of ginsenoside on the apoptosis and proliferation of human OS MG-63 and Saos-2 cells by regulating the expression of β-catenin. Read More

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http://dx.doi.org/10.3233/CBM-182046DOI Listing

CCDC6, a gene product in fusion with different protoncogenes, as a potential chemotherapeutic target.

Cancer Biomark 2019 Mar 15. Epub 2019 Mar 15.

School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India.

Cancer, a deadly disease is characterized by abnormal cell growth with the potential to invade to other parts of the body. Most cancers start due to changes at gene level that happen over a person's lifetime when DNA repair system becomes faulty. CCDC6, one of the players in DNA repair system acts as a tumor suppressor gene. Read More

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http://dx.doi.org/10.3233/CBM-181601DOI Listing
March 2019
1 Read
1.186 Impact Factor

Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a.

Cancer Biomark 2019 ;24(3):269-277

Zibo City Key Laboratory of Individualized Diagnosis and Transformation of Breast Cancer, Zibo Central Hospital, Zibo, Shandong 255036, China.

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. Read More

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http://dx.doi.org/10.3233/CBM-182216DOI Listing
January 2019

MiR-19b and miR-20a suppress apoptosis, promote proliferation and induce tumorigenicity of multiple myeloma cells by targeting PTEN.

Cancer Biomark 2019 ;24(3):279-289

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Multiple myeloma (MM) is a common hematological malignancy that is often associated with osteolytic lesions, anemia and renal impairment. Deregulation of miRNA has been implicated in the pathogenesis of MM. It was found in our study that miR-19b and miR-20a as members of crucial oncogene miR-17-92 cluster were differentially expressed between patients with MM and normal controls by genechip microarray, and this result was further confirmed in sera of patients with MM by qRT-PCR. Read More

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http://dx.doi.org/10.3233/CBM-182182DOI Listing
January 2019

Expression levels of miR-143-3p and -424-5p in colorectal cancer and their clinical significance.

Cancer Biomark 2019 ;24(3):291-297

Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Colorectal cancer (CRC) is one of the most prevalent cancers and microRNAs are involved in colorectal carcinogenesis and progression. The role of our candidate microRNAs (miR-143-3p, -424-5p, -212-3p and -34a-3p) have been investigated in various cancers.

Objective: The aim of the current study was to evaluate expression levels of microRNAs (miR-143-3p, -424-5p, -212-3p and -34a-3p) in the sera of patients with CRC in order to identify potential non-invasive biomarker for CRC and investigate the relationship between their expression and clinicopathological features of CRC. Read More

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http://dx.doi.org/10.3233/CBM-182171DOI Listing
January 2019

MiR-223 promotes oral squamous cell carcinoma proliferation and migration by regulating FBXW7.

Cancer Biomark 2019 ;24(3):325-334

Department of Stomatology, Yantai Yuhuangding Hospital, Shandong, China.

Abnormally expressed microRNAs (miRNAs) contribute widely to human cancer, including oral squamous cell carcinoma (OSCC), by regulating their downstream targets. MiR-223 has been proved to be up-regulated in both gastric cancer and ovarian cancer. However, the effect of miR-223 on OSCC is still unclear. Read More

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http://dx.doi.org/10.3233/CBM-181877DOI Listing
January 2019

Immunohistochemical assessment of cyclin D1 and p53 is associated with survival in childhood malignant peripheral nerve sheath tumor.

Cancer Biomark 2019 ;24(3):351-361

Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.

Background: Malignant peripheral nerve sheath tumor (MPNST) is rare, aggressive soft tissue sarcoma which may affect children.

Objective: We aimed to assess prognostic significance of immunohistochemical (IHC) markers, osteopontin, fibronectin, survivin, cyclin D1 and p53, in pediatric MPNST.

Methods: A total of 26 pediatric MPNST patients were enrolled in the current study with a median follow-up of 51 months. Read More

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http://dx.doi.org/10.3233/CBM-181572DOI Listing
January 2019
1 Read

Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma.

Cancer Biomark 2019 ;24(3):371-382

Lung cancer is a malignant tumor with high morbidity and mortality, of which 80% is non-small cell lung cancer (NSCLC). And lung adenocarcinoma (LUAD) is the most important and common subtype in the NSCLC. In current study, the microarray data GSE31210 containing LUAD (n= 226) and normal lung tissue (n= 20) was analyzed to identify 965 differentially expressed genes, on which weighted gene co-expression network analysis was performed. Read More

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http://dx.doi.org/10.3233/CBM-181512DOI Listing
January 2019
7 Reads

Role of miR-337-3p and its target Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells.

Authors:
Xiao-Ming Cao

Cancer Biomark 2019 ;24(3):257-267

Objective: To investigate the role of miR-337-3p targeting Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells.

Methods: The expression levels of miR-337-3p and Rap1A in cervical cancer tissues and normal tissues were evaluated through quantitative Real-time PCR (qRT-PCR) and Western blotting; and correlations of miR-337-3p with clinicopathological characteristics and prognosis of patients were also analyzed. Besides, human cervical cancer cell line HeLa cells were randomly divided into five groups (Mock, NC, miR-337-3p mimic, Rap1A, and miR-337-3p mimic + Rap1A groups). Read More

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http://dx.doi.org/10.3233/CBM-181225DOI Listing
January 2019

Erratum.

Authors:

Cancer Biomark 2019 Mar 13. Epub 2019 Mar 13.

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http://dx.doi.org/10.3233/CBM-179556DOI Listing

Identification of serum miR-30a-5p as a diagnostic and prognostic biomarker in colorectal cancer.

Cancer Biomark 2019 ;24(3):299-305

Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Circulating microRNAs (miRNAs) have become increasingly appreciated in the diagnosis and prognosis of colorectal cancer (CRC).

Objective: The aim of this study was to assess the potential diagnostic and prognostic significance of serum miR-30a-5p as a potential biomarker.

Methods: The expression levels of serum miR-30a-5p were measured in 138 cases with CRC, 50 cases with benign lesions (colorectal adenoma and polyps) and 60 healthy volunteers by quantitative real time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.3233/CBM-182129DOI Listing
January 2019
7 Reads

Elevated platelet distribution width predicts poor prognosis in hepatocellular carcinoma.

Cancer Biomark 2019 ;24(3):307-313

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Background: Previous studies have demonstrated that platelets play an important role in growth, invasion, and angiogenesis of a variety of tumors. Nevertheless, the prognostic role of platelet indices in hepatocellular carcinoma (HCC) has not been explored. The aim of this study was to explore the association between platelet indices and prognosis in HCC. Read More

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http://dx.doi.org/10.3233/CBM-182076DOI Listing
January 2019
4 Reads

The role of lipocalin-2 serum levels in the diagnostics of endometrial cancer.

Cancer Biomark 2019 ;24(3):315-324

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.

Background: Endometrial cancer is one of the most common tumor of the woman genital organs.

Objective: The goal of this study was to determine the lipocalin-2 levels in patients with endometrial cancer compared to those with normal endometrium or mild endometrial pathologies.

Methods: Study included 123 patients with BMI > 21 kg/m2 who were admitted due to abnormal bleeding, in which 52 patients with endometrial cancer. Read More

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http://dx.doi.org/10.3233/CBM-181942DOI Listing
January 2019
2 Reads

Prognostic potential of the preoperative plasma complement factor B in resected pancreatic cancer: A pilot study.

Cancer Biomark 2019 ;24(3):335-342

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, College of Medicine, Yonsei University, Seoul, Korea.

Background: For patients with pancreatic cancer, a preoperative assessment of prognosis is crucial to predict cancer recurrence and to prepare a postoperative adjuvant strategy and appropriate patient-counsel.

Objective: We evaluated the prognostic predictive power of complement factor B (CFB) by comparing it to that of other known tumor markers in resected pancreatic cancer patients.

Methods: From 2012 to 2013 period, we retrospectively reviewed the plasma CFB levels of 35 pancreatic cancer patients. Read More

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http://dx.doi.org/10.3233/CBM-181847DOI Listing
January 2019

EGFLAM correlates with cell proliferation, migration, invasion and poor prognosis in glioblastoma.

Cancer Biomark 2019 ;24(3):343-350

Department of Abdominal Radiotherapy, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China.

EGFLAM as a novel gene biomarker has been reported in some cancers but not glioblastoma (GBM) yet. To clarify the functional role of EGFLAM in GBM, we performed this study. Firstly, based on TCGA and Oncomine database, EGFLAM expression and clinical significance in GBM patients was analyzed. Read More

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http://dx.doi.org/10.3233/CBM-181740DOI Listing
January 2019
1 Read

DNA polymerase iota (Pol ι) promotes the migration and invasion of breast cancer cell via EGFR-ERK-mediated epithelial to mesenchymal transition.

Cancer Biomark 2019 ;24(3):363-370

Department of Radio-Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.

Background And Objective: Dysregulation of DNA polymerase iota (Pol ι) in breast cancer might contribute to the accumulation of genomic mutations and promotes breast cancer progression. In this study we explored the clinical relevance and biological function of Pol ι in breast cancer.

Methods: qRT-PCR was used to determine the expression levels of Pol ι in 31 breast cancer tissues. Read More

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http://dx.doi.org/10.3233/CBM-181516DOI Listing
January 2019
1.186 Impact Factor

Upregulation of miR-183-5p predicts worse survival in patients with renal cell cancer after surgery.

Cancer Biomark 2019 ;24(2):153-158

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China.

Objective: Renal cell carcinoma (RCC) is one of the most common genitourinary cancers, and advanced RCC usually leads to poor prognosis. Therefore, identifying novel biomarkers for predicting the progression and prognosis of RCC is essential. The present study aims to evaluate the clinical value of miR-183-5p in RCC development and prognosis after surgery. Read More

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http://dx.doi.org/10.3233/CBM-182047DOI Listing
January 2019
1 Read

Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer.

Cancer Biomark 2019 Jan 15. Epub 2019 Jan 15.

Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Circular RNAs (circRNA) play key regulatory roles in cancer progression. Human circRNA microarray was performed to screen for abnormally expressed circRNA in gastric cancer tissues. In this study, we found circRNA102958 was up-regulated in gastric cancer tissues and cell lines. Read More

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http://dx.doi.org/10.3233/CBM-182029DOI Listing
January 2019
2 Reads

Identification of biomarkers associated with progression and prognosis in bladder cancer via co-expression analysis.

Cancer Biomark 2019 ;24(2):183-193

Background: Bladder cancer is one of the most common genitourinary malignancies, with a high rate of recurrence and progression. The prognosis for patients with bladder cancer, especially muscle-invasive bladder cancer, remains poor despite systemic therapy.

Objective: To explore the underlying disease mechanisms and identify more effective biomarkers for bladder cancer. Read More

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http://dx.doi.org/10.3233/CBM-181940DOI Listing
January 2019

Esculetin enhances the inhibitory effect of 5-Fluorouracil on the proliferation, migration and epithelial-mesenchymal transition of colorectal cancer.

Cancer Biomark 2019 ;24(2):231-240

Department of Oncology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China.

Background: Colorectal cancer (CRC) is the most common malignant disease worldwide and thus new therapeutic approaches are needed. 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Read More

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http://dx.doi.org/10.3233/CBM-181764DOI Listing
January 2019
5 Reads

RASSF1A and SOCS1 genes methylation status as a noninvasive marker for hepatocellular carcinoma.

Cancer Biomark 2019 ;24(2):241-247

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: DNA methylation status is one of the most prevalent molecular alterations in human cancers. Identification of powerful diagnostic and prognostic biomarkers for hepatocellular carcinoma (HCC) without a biopsy is urgently required.

Objective: The purpose of this study was to determine the methylation status of RASSF1A and SOCS-1genes as a non-invasive biomarker for HCC identification and prognosis. Read More

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http://dx.doi.org/10.3233/CBM-181638DOI Listing
January 2019
1 Read

Potential diagnostic and prognostic value of plasma long noncoding RNA LINC00086 and miR-214 expression in gastric cancer.

Cancer Biomark 2019 ;24(2):249-255

People's Hospital of Hengshui City, Hengshui, Hebei, China.

Background: Plasma carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4) are common markers which are useful in the diagnosis and prognosis of GC. However, their sensitivity and specificity in GC remain unsatisfactory. Identification of cancer diagnosed-biomarkers would be of great value. Read More

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http://dx.doi.org/10.3233/CBM-181486DOI Listing
January 2019

The association of Bcl-xL and p53 expression with survival outcomes in oropharyngeal cancer.

Cancer Biomark 2019 ;24(2):141-151

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Background: The role of molecular biomarkers in oropharyngeal squamous cell carcinoma (OPSCC) has recently been increasingly recognized. There is conflicting evidence in the literature with regards to the prognostic value of p53 and Bcl-xL.

Objective: The purpose of this study was to investigate the association between p53 and Bcl-xL expression profiles and survival outcomes in OPSCC. Read More

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http://dx.doi.org/10.3233/CBM-182106DOI Listing
January 2019
12 Reads

MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer.

Cancer Biomark 2019 ;24(2):159-172

Background: A growing body of studies have demonstrated the aberrant expression of microRNAs (miRNAs) contributes to human tumor metastasis. MicroRNA-124-3p (miR-124-3p), which is down-regulated in various cancers, has been found to be involved in several signaling pathways relevant to tumor cell migration and invasion. However, the roles of miR-124-3p in human bladder cancer remain unclear. Read More

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http://dx.doi.org/10.3233/CBM-182000DOI Listing
January 2019
10 Reads

The therapeutic role of inhibition of miR-328 on pulmonary carcinoma induced by chlamydia pneumoniae through targeting histone H2AX.

Cancer Biomark 2018 Dec 27. Epub 2018 Dec 27.

Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.

Lung cancer represents a major healthy concern due to high incidence and morality. Increasing evidences showed critical regulatory role of microRNA (miR) in cell growth, differentiation and apoptosis. It has been indicated that the level of miR-328 is abnormally up regulated in lung cancer cell line, which is correlated with cell apoptosis. Read More

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http://dx.doi.org/10.3233/CBM-181999DOI Listing
December 2018
8 Reads

MicroRNA-18a promotes proliferation and metastasis in oral squamous cell carcinoma via targeting KLF4.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Oral squamous cell carcinoma (OSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to explore the regulatory mechanism of microRNA-18a in OSCC cells proliferation and metastasis. Quantitative real-time PCR (qRT-PCR) was used to detect the expression level of miR-18a and KLF4 mRNA in OSCC tissues and cell lines (SCC-25, CAL-27, Tca-8113). Read More

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http://dx.doi.org/10.3233/CBM-181943DOI Listing
December 2018
11 Reads

Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma.

Cancer Biomark 2019 ;24(2):195-201

Department of Hematology, Gansu Provincial Hospital, Lanzhou, Gansu, China.

Objective: Human multiple myeloma (MM) is a kind of common tumor in middle-aged and elderly people, in which the osteolytic lesion is formed mainly through inhibiting osteoblast (OB) differentiation and promoting osteoclast (OC) differentiation. Dickkopf-1 (DKK1) is a soluble Wnt inhibitor, which has an important correlation with the pathogenesis of human MM. Therefore, the correlations of DKK1 with pathogenesis and prognosis of human MM were investigated in this study. Read More

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http://dx.doi.org/10.3233/CBM-181909DOI Listing
January 2019
8 Reads

Modulation on gallbladder carcinoma by TGF-β1 via IGFBP-2.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China.

Gallbladder carcinoma (GC) occupies more than 90% of all cancers in biliary tract with an increasing incidence. Most patients with GC are already at terminal stage at the time of primary diagnosis, causing unfavorable prognosis and high mortality. Transformation growth factor-beta (TGF-β) is up-regulated in GC. Read More

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http://dx.doi.org/10.3233/CBM-181895DOI Listing
December 2018
9 Reads
1.186 Impact Factor

Downregulation of the expression of the lncRNA MIAT inhibits melanoma migration and invasion through the PI3K/AKT signaling pathway.

Cancer Biomark 2019 ;24(2):203-211

Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.

Background: Long noncoding RNA MIAT expression is related to the development of some diseases. However, the role of MIAT in melanoma was has seldom been studied.

Objective: To investigate the effect of the lncRNA MIAT on melanoma cells. Read More

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http://dx.doi.org/10.3233/CBM-181869DOI Listing
January 2019
2 Reads
1.186 Impact Factor

Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer.

Cancer Biomark 2019 ;24(2):213-221

Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.

Objectives: To investigate TCF4 expression in epithelial ovarian cancer, and to explore its correlation with clinicopathological parameters and clinical prognosis of epithelial ovarian cancer.

Methods: From 2009 to 2017, 188 cases of paraffin-embedded epithelial ovarian cancer tissues and 41 paratumor ovarian tissues which had been confirmed at the memorial hospital of Sun Yat-sen University were collected in this study, and the expression of TCF4 was performed by immunohistochemistry using a polyclonal antibody specific for TCF4.

Results: The expression of TCF4 protein was associated with disease progression free survival and overall survival in epithelial ovarian cancer patients; and TCF4 overexpression was associated with age, FIGO stage, lymph node metastasis, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence, and serum CA153. Read More

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http://dx.doi.org/10.3233/CBM-181849DOI Listing
January 2019
21 Reads

Gene expression profiling identifies potential molecular markers of papillary thyroid carcinoma.

Cancer Biomark 2019 ;24(1):71-83

Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA.

Background: Thyroid cancer is the most common endocrine malignancy worldwide, with the predominant form papillary thyroid carcinoma (PTC) representing approximately 80% of cases.

Objective: This study was addressed to identify potential genes and pathways involved in the pathogenesis of PTC and potential novel biomarkers for this disease.

Methods: Gene expression profiling was carried out by DNA microarray technology. Read More

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http://dx.doi.org/10.3233/CBM-181758DOI Listing
January 2019
13 Reads

The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer.

Cancer Biomark 2019 ;24(1):51-59

High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, China.

Background: Cisplatin-based chemotherapy and radiotherapy are the most commonly used treatments for small cell lung cancer (SCLC). However, despise initially dramatic response, the response duration of SCLC patients is variable and resistance to chemo- and radio-therapy inevitably develops.

Objective: The aim of the study is to investigate the role of Bcl-2 family proteins in predicting SCLC sensitivity to cisplatin treatment, and to identify the potential sensitizer of cisplatin or ratiation treatment in SCLC. Read More

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http://dx.doi.org/10.3233/CBM-181692DOI Listing
January 2019
2 Reads

MiR-27a promotes EMT in ovarian cancer through active Wnt/𝜷-catenin signalling by targeting FOXO1.

Cancer Biomark 2019 ;24(1):31-42

Department of Gynecology, Huizhou No. 2 Women's and Children's Healthcare Hospital, Huizhou, Guangdong 516001, China.

Background: Ovarian cancer (OC) is the fifth most common type of cancer in women worldwide. MiR-27a plays an important role in the development of ovarian cancer. However, the exact function and molecular mechanism of miR-27a in epithelial-mesenchymal transition (EMT) has not been thoroughly elucidated to date. Read More

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http://dx.doi.org/10.3233/CBM-181229DOI Listing
January 2019
4 Reads

Frameshift mutation of candidate tumor suppressor genes QK1 and TMEFF2 in gastric and colorectal cancers.

Cancer Biomark 2019 ;24(1):1-6

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Both QKI and TMEFF2 genes are considered putative tumor suppressor genes (TSGs). In gastric (GC) and colorectal (CRC) cancers, downregulation of their expressions is known to be frequent. However, QKI and TMEFF2 mutations that could potentially inactivate their functions are not reported in cancers. Read More

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http://dx.doi.org/10.3233/CBM-160559DOI Listing
January 2019
4 Reads

miR-378 serves as a prognostic biomarker in cholangiocarcinoma and promotes tumor proliferation, migration, and invasion.

Cancer Biomark 2019 ;24(2):173-181

MicroRNAs (miRNAs) have been demonstrated that play a critical role in tumorigenesis. The aim of this study is to identify the functional role of miR-378 in cholangiocarcinoma (CCA). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression levels of miR-378 in human CCA tissue samples and CCA cell lines. Read More

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http://dx.doi.org/10.3233/CBM-181980DOI Listing
January 2019
2 Reads