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    862 results match your criteria Cancer Biomarkers [Journal]

    1 OF 18

    Bortezomib could down-regulate the expression of RANKL, inhibit cell proliferation and induce cell apoptosis in the human myeloma cell line RPMI 8226 by activating casepase-3.
    Cancer Biomark 2017 Aug;20(2):217-224
    Department of Hematology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, Zhejiang, China.
    Objective: In spite of bortezomib being developed and demonstrated as a safe drug therapy for multiple myeloma (MM), the role of bortezomib-induced receptor activator of nuclear factor (NF)-κB ligand (RANKL) in the MM cell lines remains to be understood. Thus the present study aims to explore the impact of bortezomib on RANKL expression, cell growth and apoptosis in human myeloma cell line RPMI 8226.

    Methods: Four experiment groups were set according to different concentrations of bortezomib, namely blank group (treated with DMEM solution free of other drugs), low-dose group (treated with 10 nmol/L bortezomib), middle-dose group (treated with 20 nmol/L bortezomib) and high-dose group (treated with 40 nmol/L bortezomib). Read More

    MiR-135a-5p modulates biological functions of thyroid carcinoma cells via targeting VCAN 3'-UTR.
    Cancer Biomark 2017 Aug;20(2):207-216
    Department of Emergency Surgery, Qingdao Hiser Medical Center, Qingdao 266001, Shandong, China.
    Thyroid carcinoma is one of the most frequent malignant tumors of the endocrine system, which accounts for nearly 1% population in newly diagnosed carcinoma worldwide and the incidence has an increasing tendency in recent years. To explore whether miR-135a-5p could affect the proliferation, invasion and migration of thyroid carcinoma cells by targeting VCAN. The expression levels of miR-135a-5p and VCAN were detected in human thyroid carcinoma tissues and cells, para-carcinoma tissues, as well as human normal thyroid cells using RT-qPCR and Western blot. Read More

    Spalt-like transcription factor 4 as a potential diagnostic and prognostic marker of colorectal cancer.
    Cancer Biomark 2017 Aug;20(2):191-198
    Objective: The study aimed to investigate the role of spalt-like transcription factor 4 (SALL4) in the diagnosis and prognosis of colorectal cancer (CRC).

    Methods: Between May 2008 and January 2010, 135 patients with CRC were recruited and subsequently assigned into the case group of the study. Additionally, 140 healthy individuals under identical conditions were selected as the control group. Read More

    IDH1 status is significantly different between high-grade thalamic and superficial gliomas.
    Cancer Biomark 2017 Aug;20(2):183-189
    Department of Neurosurgery, Sichuan University, West China Hospital, Chengdu, Sichuan, China.
    Background: While major progress has been made in diagnosis and treatment of gliomas based on molecules, molecular features of thalamic glioma have rarely been reported till now.

    Objective: IDH1 mutation is important for prognosis of gliomas and represents a distinctive category of glioma. We intended to survey specific molecular abnormalities in high-grade thalamic gliomas (WHO III-IV). Read More

    Propofol-induced neurotoxicity in hESCs involved in activation of miR-206/PUMA signal pathway.
    Cancer Biomark 2017 Aug;20(2):175-181
    Department of Clinical Laboratory, People's Hospital of Weifang, Weifang, Shandong, China.
    Background And Objective: Studies in developing animals have demonstrated that when anesthetic agents, such as propofol, are early administered in life, it can lead to neuronal cell death and learning disabilities. However, the mechanisms causing these effects remains unknown. A recent report found that propofol could significantly upregulat miR-206 expression in the human ASCs. Read More

    Large intergenic non-coding RNA-ROR as a potential biomarker for the diagnosis and dynamic monitoring of breast cancer.
    Cancer Biomark 2017 Aug;20(2):165-173
    Department of Environmental Health and Occupational Medicine, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
    Background: Recent study has revealed that large intergenic non-coding RNA-ROR (linc-ROR) is aberrantly expressed in a number of cancers including breast cancer. However, whether circulating linc-ROR in plasma could be used for breast cancer diagnosis and dynamic monitoring is not clear.

    Objective: The objective of this study is to determine if plasma linc-ROR could be applied as a biomarker for the diagnosis and dynamic monitoring of breast cancer. Read More

    High concentration of miR-133 is a useful marker for the diagnosis of lymphoma- associated hemophagocytic syndrome.
    Cancer Biomark 2017 Aug;20(2):159-164
    Hermatology Department, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330029, China.
    Background: Lymphoma associated hemophagocytic syndrome (LAHS) is one of the major adult secondary hemophagocytic lymphohistiocytosis (HLH). Early diagnosis and treatment contribute to improved outcome. No enlarge lymph nodes can often delay the diagnosis of underlying lymphoma. Read More

    bFGF in tumor tissue independently prognosticates disease outcome of a natural course of invasive breast cancer.
    Cancer Biomark 2017 Aug;20(2):151-158
    Background: Basic fibroblast growth factor (bFGF) is a potent angiogenic and mitogenic factor that has been functionally predisposed to promote tumorigenesis, while literature data also associate bFGF with a favorable outcome of breast cancer.

    Objective: In order to help resolve such controversy, this study set out to investigate the role of bFGF in breast cancer for the first time by use of the node-negative patient group with smaller tumors and without any systemic adjuvant therapy. This has allowed an increased homogeneity of the group and a far more reliable interpretation of results. Read More

    Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
    Cancer Biomark 2017 Aug;20(2):143-150
    Department of Clinical Laboratory, Yantaiyuhuangding Hospital, Yantai, Shandong, China.
    Objective: The 14-3-3 family of conserved regulatory proteins comprises the isoforms beta (β), gamma (γ), zeta (ζ), sigma (ε), tau (η), and delta (σ), which are overexpressed and associated with a high risk of metastasis and poor survival in hepatocellular carcinoma (HCC). In the present study, we investigated whether serum 14-3-3 isoforms are related to HCC progression and patient survival.

    Methods: Serum samples from 63 HCC patients who underwent surgical reSection 104 HCC patients who received non-surgical anti-HCC treatments, 50 patients with liver cirrhosis alone, 45 patients with chronic hepatitis alone, and 50 healthy subjects were collected between January 2006 and December 2010. Read More

    Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
    Cancer Biomark 2017 Aug;20(2):123-133
    Medical Applied Chemistry, MRI, Alexandria University, Alexandria, Egypt.
    Background: The key regulator of tumor metabolome is the glycolytic isoenzyme M2-PK which favors the generation of nucleic acid via glutaminolysis as hypoxic adaptive mechanism in the tumor cells.

    Aim: The study aimed to evaluate the prognostic role of M2-PK, CRP, and CA 15-3 in preoperative and metastatic breast carcinomas.

    Patients And Methods: The study included 70 females; 15 controls, 33 preoperative primary breast carcinomas clinically metastasis free, and 22 clinically diagnosed metastatic breast carcinomas. Read More

    Pregnancy-associated gigantomastia recurrence and ectopic breast after reduction mammaplasty: A case report.
    Cancer Biomark 2017 Aug;20(2):225-229
    It has been reported that majority of cases of gigantomastia, also known as breast hypertrophy and macromastia, occur during either pregnancy or puberty. Gigantomastia is a rare disorder that does not have a clear etiology or well-established risk factors. We present a 26-year-old female patient who appeared to have pregnancy-associated gigantomastia recurrence, large accessory breast and, ectopic breast tissue at external genital three years after bilateral breast reduction surgery. Read More

    Alpha-2-HS-glycoprotein plasma level decrease correlates with age in patients with myelodysplastic syndromes.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Backgound: It has been indicated in plasma proteomic studies on different myelodysplastic syndrome (MDS) cohorts that alpha-2-HS-glycoprotein could be a promising MDS biomarker candidate.

    Objective: The goal of this work was to estimate alpha-2-HS-glycoprotein (AHSG) plasma levels and its biomarker value in the low- and high-risk subgroups of MDS patients.

    Methods: The level of AHSG was estimated for 115 plasma samples using ELISA. Read More

    Improvement of cytotoxicity of autologous CIKs from patients with breast cancer to MCF-7 cells by suppressed PD-1 expression.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Department of Oncology, Anhui Provincial Hospital, Hefei 230033, Anhui, China.
    Objective: To investigate the improvement of cytotoxicity of autologous CIKs from patients with breast cancer to MCF-7 cells by suppressed PD-1 expression.

    Methods: The Lentiviral Vector/PD-1 carrying the gene that can suppressed PD-1 was transferred to CIK cells from patients with breast cancer to inhibit PD-1 expression. The PD-1 protein were detected by RT-PCR and Western blot. Read More

    Downregulation of Piwil3 suppresses cell proliferation, migration and invasion in gastric cancer.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Background: Gastric cancer is one of the most common malignancies worldwide. Recent studies reported that Piwil3 was overexpressed in various cancers, including gastric cancer (GC). This study was intended to investigate its function and mechanism in GC progress. Read More

    Epithelial-mesenchymal transition phenotypes of circulating tumor cells correlate with the clinical stages and cancer metastasis in hepatocellular carcinoma patients.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Background: Epithelial-mesenchymal transition (EMT) plays a crucial role in circulating tumor cells (CTCs) dissemination and cancer metastasis.

    Objective: To investigate the EMT phenotypes of CTCs in hepatocellular carcinoma (HCC) patients and the clinical utility in the early diagnosis of HCC metastasis and progression.

    Methods: We retrospectively analyzed the count and EMT classification of CTCs detected by the CanPatrol® platform in 195 HCC patients. Read More

    Decreased expression of MUC1 induces apoptosis and inhibits migration in pancreatic cancer PANC-1 cells via regulation of Slug pathway.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Department of Hepatobiliary Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    MUC1, a membrane tethered mucin glycoprotein, is overexpressed in > 60% of human pancreatic cancers (PCs), and is associated with poor prognosis and enhanced metastasis. Here, we report the effect of silencing MUC1 expression on the growth, migration and invasive ability of pancreatic cancer cells, and explored its mechanisms. We observed that siRNA mediated suppression of the MUC1 expression significantly reduced invasive and migrative capability and induced apoptosis of the pancreatic cancer PANC-1 cells. Read More

    A 4-miRNAs signature predicts survival in glioblastoma multiforme patients.
    Cancer Biomark 2017 Aug 25. Epub 2017 Aug 25.
    Institute of Neurology, The Second Hospital, Lanzhou University, Lanzhou, Gansu 730030, China.
    Background: Although O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation status is an important marker for glioblastoma multiforme (GBM), there is considerable variability in the clinical outcome of patients with similar methylation profles.

    Objective: We examined whether a MicroRNA (miRNA) signature can be identified for predicting clinical outcomes and helping in treatment decisions.

    Methods: The differentially expressed miRNAs were evaluated in 6 pairs of short- (⩽ 450 days) and long-term survivors (> 450 days) by using microarray. Read More

    Prognostic role of BiP/GRP78 expression as ER stress in patients with Gastric Adenocarcinoma.
    Cancer Biomark 2017 Aug 11. Epub 2017 Aug 11.
    Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
    Purpose: The glucose-regulated protein 78 (GRP78), also referred to as immunoglobulin heavy chain binding protein (BiP) (BiP/GRP78), is a major molecular chaperone in the endoplasmic reticulum (ER) and is extensively expressed in human neoplasms. Although the enhanced expression of BiP/GRP78 has been described to be associated with poor prognosis in gastric cancer (GC), details regarding its prognostic significance remain unclear. The aim of this study was to elucidate the prognostic role of BiP/GRP78 in patients with GC. Read More

    Case analysis of temporal bone lesions with facial paralysis as main manifestation and literature review.
    Cancer Biomark 2017 Aug;20(2):199-205
    Objective: This study aims to discuss clinical characteristics, image manifestation and treatment methods of temporal bone lesions with facial paralysis as the main manifestation for deepening the understanding of such type of lesions and reducing erroneous and missed diagnosis.

    Methods: The clinical data of 16 patients with temporal bone lesions and facial paralysis as main manifestation, who were diagnosed and treated from 2009 to 2016, were retrospectively analyzed. Among these patients, six patients had congenital petrous bone cholesteatoma (PBC), nine patients had facial nerve schwannoma, and one patient had facial nerve hemangioma. Read More

    Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis.
    Cancer Biomark 2017 Aug 11. Epub 2017 Aug 11.
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
    Oral submucous fibrosis (OSF) is a chronic insidious disease which predisposes to oral cancer. Understanding the molecular markers for OSF is critical for diagnosis and treatment of oral cancer. In this study, the proteins expression profile of OSF tissues was compared to normal mucous tissues by 2 dimensional electrophoresis (2-DE). Read More

    MiR-338 suppresses cell proliferation and invasion by targeting CTBP2 in glioma.
    Cancer Biomark 2017 Aug 11. Epub 2017 Aug 11.
    Department of Nuclear Medicine, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin, China.
    Background: Previous studies indicated that microRNA-338-5p (miR-338-5p) functions as tumor suppressor in some cancer types including glioma. However, the clinical significance and biological function of miR-338-5p in glioma still need to be explored.

    Methods: We used quantitative real time PCR (qRT-PCR) to detect the miR-338-5p expression in the 44 cases of glioma tissues and adjacent normal tissues. Read More

    Evaluation of pretreatment red cell distribution width in patients with multiple myeloma.
    Cancer Biomark 2017 Aug 11. Epub 2017 Aug 11.
    Department of Hematology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
    Background: Red blood cell distribution width (RDW) has been reported as an inflammatory biomarker and a predictor of prognosis in different types of cancer. However, the role of RDW at diagnosis in patients with multiple myeloma (MM) has been less explored.

    Objective: We aimed to investigate the association between RDW and the response to treatment and overall survival (OS) in patients with MM. Read More

    The impact of chemotherapy-associated hemoglobin on prognosis of colorectal cancer patients receiving adjuvant chemotherapy.
    Cancer Biomark 2017 Aug 1. Epub 2017 Aug 1.
    Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
    Background And Objective: The association of chemotherapy-associated hemoglobin and survival of colorectal cancer (CRC) receiving adjuvant chemotherapy is uncertain. We sought to explore the prognostic value of chemotherapy-associated hemoglobin in CRC receiving adjuvant chemotherapy and the best cut point affecting prognosis.

    Methods: Three hundred and twenty stage II and III CRC patients receiving adjuvant FOLFOX chemotherapy from March 2003 to March 2012 were enrolled. Read More

    Ensemble methods integrated with miRNA expression data for predicting miRNA targets in stomach adenocarcinoma.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    Department of Medicine, Shandong Medical College, Jinan, Shandong, China.
    Objective: It is crucially important to discover the relationships between genes and microRNAs (miRNAs) in cancer. Thus, we proposed a combined bioinformatics method integrating Pearson's correlation coefficient (PCC), Lasso, and causal inference method (IDA) to identify the potential miRNA targets for stomach adenocarcinoma (STAD) using Borda count election.

    Materials And Methods: Firstly, the ensemble method integrating PCC, IDA, and Lasso was used to predict miRNA targets. Read More

    miR-503-3p induces apoptosis of lung cancer cells by regulating p21 and CDK4 expression.
    Cancer Biomark 2017 Jul 28. Epub 2017 Jul 28.
    Department of Clinical Laboratory, Yantaishan Hospital, Yantai, Shandong, China.
    Studies have shown that microRNAs (miRNAs) can promote or suppress tumor growth and therefore act as targets for cancer therapy. Hsa-miR-503-5p, a mature miRNA derived from 5' ends of pre-miR-503, has been proved to regulate cell proliferation, transformation, migration and invasion. However, the biological function of miR-503-3p derived from 3' ends of pre-miR-503 has never been reported. Read More

    MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS).
    Cancer Biomark 2017 Jul 2. Epub 2017 Jul 2.
    Department of Surgery, Children's Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215000, China.
    Neuroblastoma is a brain malignancy of childhood and accounts for 7-10% of childhood cancers, leading to approximately 15% of pediatric cancer deaths. MicroRNAs (miRNAs) are a family of short (about 18-25 nucleotides), noncoding and single stranded endogenous RNAs, which complementarily bind to the 3' untranslated regions of their target genes. Recently, glutamine metabolism has been recognized as an important nutrition source for tumor cells, and hence targeting glutamine metabolism could benefit to development of anti-cancer agents. Read More

    Identification of prostate cancer hub genes and therapeutic agents using bioinformatics approach.
    Cancer Biomark 2017 Jul 30. Epub 2017 Jul 30.
    Background: Prostate cancer (PCa) is the most common and the second leading cause of cancer-related death among men in America. As the molecular mechanism of PCa has not yet been completely discovered, identification of hub genes and potential drug of this disease is an important area of research that could provide new insights into exploring the mechanisms underlying PCa.

    Objective: The aim of this study was to identify potential biomarkers and novel drug for prostate cancer treatment. Read More

    Prognostic significance of low miR-144 expression in gastric cancer.
    Cancer Biomark 2017 Jul 2. Epub 2017 Jul 2.
    Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
    Background: An overwhelming amount of evidence has emerged suggesting that dysregulated microRNAs (miRNAs) play crucial roles in tumorigenesis.

    Objective: The study was to analyze tissue/serum miR-144 expression in gastric cancer and then evaluate their potential to predict the prognosis of gastric cancer.

    Methods: We examined miR-144 levels in tissues and peripheral blood samples from 96 gastric cancer patients using real-time PCR. Read More

    MiR-99a suppresses proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inhibiting the IGF1R signaling pathway.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    miR-99a is down-regulated in esophageal squamous cell carcinoma (ESCC), however the role and underlying mechanism are still unknown. We aim to explore the role and mechanism of miR-99a down-regulation in ESCC. The expression of miR-99a in ESCC tissues and cell lines was detected by Human miRNA Microarrays and Real-time PCR. Read More

    Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    Key Laboratory of Chronobiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
    Background: Long noncoding RNAs (lncRNA) have been verified to be involved in hepatocellular carcinoma (HCC) progression. However, the potential biologic function of PVT1 in HCC is not still fully known.

    Methods: PVT1 and miR-214 were detected by qRT-PCR assays in HCC tissues and adjacent normal tissues. Read More

    Clinical validation of the CE-IVD marked Therascreen MGMT kit in a cohort of glioblastoma patients.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    CHU Timone, Marseille, France.
    Background: Pyrosequencing is recognized as a strong technique to analyze the MGMT status of glioblastoma patients. The most commonly used assay, quantifies the methylation levels of CpGs 74 to 78. A more recent CE-marked In Vitro Diagnostic Medical Device (CE-IVD) assay, Therascreen, analyzes CpGs 76-79. Read More

    Circulating endothelial cells and microparticles for prediction of tumor progression and outcomes in advanced non-small cell lung cancer.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    Radiobiology Laboratory, Biotechnology Department, Atomic Energy Commission of Syria, Damascus, Syria.
    Background: Circulating endothelial cells (CECs) and microparticles (MPs) are proposed as useful biosensors for angiogenesis and membrane damage in cancer.

    Objective: We investigated their predictive value for progression disease (PD) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with cytotoxic chemotherapy.

    Methods: Peripheral blood samples were obtained from 60 patients. Read More

    Prognostic value of combined and individual expression of microRNA-1290 and its target gene nuclear factor I/X in human esophageal squamous cell carcinoma.
    Cancer Biomark 2017 Aug 4. Epub 2017 Aug 4.
    Background: microRNA (miR)-1290 was previously indicated to promote esophageal squamous cell carcinoma (ESCC) progression via regulating its target gene nuclear factor I/X (NFIX).

    Objective: To investigate clinical significance of miR-1290 and NFIX in ESCC.

    Methods: Quantitative real-time PCR was performed to detect miR-1290 and NFIX mRNA expression in ESCC tissues. Read More

    Nephroblastoma overexpressed gene expression and its prognostic implications of clinical outcomes in renal cell carcinoma patients.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    Department of Nephropathy, Xi'an Central Hospital, Xi'an 710003, Shaanxi, China.
    Background: The nephroblastoma overexpressed gene (NOV) expressions in tissues and organs has become abnormal during tumorigenesis and progression. This study intended to investigate the correlation between clinical outcomes and NOV expression in renal cell carcinoma (RCC) patients.

    Methods: Fifty RCC patients who attended the hospital from January 2013 to January 2015 were enrolled in this study. Read More

    The prognostic role of preoperative serum CA125 levels in patients with advanced endometrial carcinoma.
    Cancer Biomark 2017 Aug;20(2):135-141
    Reproductive Health, Nursing & Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Lifetime risk of developing endometrial cancer is 2.17%. There is controversy regarding the predictive value of Cancer Antigen 125 (CA125) in endometrial cancer as well as the significance of its relationship with prognostic factors and appropriate cut-off value. Read More

    Cancer stem cells as functional biomarkers.
    Cancer Biomark 2017 Jul 31. Epub 2017 Jul 31.
    Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
    According to the American Association of Cancer Research (AACR), a Cancer Stem Cell is a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that constitutes the tumor [1]. Cancer Stem Cells (CSCs) are involved in the metastatic process, in the resistance to therapeutic treatments of many types of human cancers and consequently in the onset of recurrences. Numerous translational studies have been conducted to understand CSC characteristics and evaluate association between CSC-related biomarkers and clinical outcomes. Read More

    Low expression of NEK2 is associated with hepatocellular carcinoma progression and poor prognosis.
    Cancer Biomark 2017 Jul;20(1):101-106
    Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China.
    Background: NIMA-related kinase 2 (NEK2), a serine/threonine kinase, is located in the centrosome and is a member of cell cycle regulation related protein kinase (CCRK) family. Aberrant expression of NEK2 is linked with carcinogenesis and progression of various tumors.

    Objective: To investigate the expression level of NEK2 and its relationship with clinicopathological factors in hepatocellular carcinoma (HCC). Read More

    Low serum miR-373 predicts poor prognosis in patients with pancreatic cancer.
    Cancer Biomark 2017 Jul;20(1):95-100
    Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
    Background: Circulating microRNAs (miRNAs) are emerging as novel biomarkers for various types of cancer including pancreatic cancer (PC).

    Objective: We aimed to explore the diagnostic and prognostic significance of serum miR-373 in PC.

    Methods: In the current study, we recruited a total of 103 PC patients, 30 patients with benign pancreatic tumor, 20 patients with chronic pancreatitis and 50 healthy volunteers. Read More

    Observation of significant biomarkers in osteosarcoma via integrating module- identification method with attract.
    Cancer Biomark 2017 Jul;20(1):87-93
    Department of Orthopaedics, Jingzhou Central Hospital, Jingzhou 434020, Hubei, China.
    Objective: Osteosarcoma (OS) is the most frequent type of bone malignancy, and this disease has a poor prognosis. We aimed to identify the significant genes related with OS by integrating module-identification method and attract approach.

    Methods: OS-related microarray data E-GEOD-36001 were obtained from ArrayExpress database, and then protein-protein interaction (PPI) networks of normal and OS were re-weighted by means of spearman correlation coefficient (SCC). Read More

    Down-regulated long non-coding RNA SNHG1 inhibits tumor genesis of colorectal carcinoma.
    Cancer Biomark 2017 Jul;20(1):67-73
    Department of Colorectal Surgery, The First Affiliated Hospital and Institute of Clinical Medicine, Zhengzhou University, Zhengzhou 450052, Henan, China.
    Background: Colorectal carcinoma (CRC) is the vital cancer mortality worldwide and the long noncoding RNAs (lncRNAs) is considered as an important biomarker. The aim of this study was to examine the influence of lncRNA-SNHG1in CRC, and explore the relationship of lncRNA-SNHG1 and CRC, and consequently find a new therapeutic target for CRC patients.

    Methods: This study used 80 CRC patients and several cancer cell lines, with RNA interference technology to find the function of SNHG1. Read More

    Long non-coding RNA Fer-1-like protein 4 acts as a tumor suppressor via miR-106a-5p and predicts good prognosis in hepatocellular carcinoma.
    Cancer Biomark 2017 Jul;20(1):55-65
    Long non-coding RNAs (lncRNAs) are aberrantly expressed in various cancers. Fer-1-like protein 4 (FER1L4), one of lncRNAs, plays a role as tumor suppressor in various human cancers and can be regulated by microRNA. However, the role and function of FER1L4 in human hepatocellular carcinoma (HCC) remains unknown. Read More

    Downregulation of miR-138 predicts poor prognosis in patients with esophageal squamous cell carcinoma.
    Cancer Biomark 2017 Jul;20(1):49-54
    Background: MicroRNAs (miRNAs) have been proven to be critical players in many different types of tumors including esophageal squamous cell carcinoma (ESCC).

    Objective: This study aimed at investigating the correlation of miR-138 expression and clinical outcome of patients with ESCC.

    Methods: A total of 168 serum samples and 128 fresh cancer tissues as well as their corresponding adjacent non-cancerous tissues were collected. Read More

    Prognostic significance of the genetic and the immunohistochemical expression of epithelial-mesenchymal-related markers in colon cancer.
    Cancer Biomark 2017 Jul;20(1):107-122
    Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: Epithelial-mesenchymal transition (EMT) is one of the main events in colorectal cancer (CRC) spread. Snail-1 is a zinc transcription factor that mediates EMT in tumor cells probably by down-regulation of E-cadherin and claudin-1.

    Objectives: To detect the expression of epithelial markers (claudin-1 and E-cadherin) and mesenchymal markers (snail-1 and vimentin) in primary cancer colon. Read More

    Nicotine cut-off value in human hair as a tool to distinguish active from passive smokers: A cross-sectional study in Japanese men.
    Cancer Biomark 2017 Jul;20(1):41-48
    Department of Hygiene & Preventive Medicine, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
    Background: Nicotine concentration in hair is a useful marker of tobacco exposure. Detection of nicotine in the hair of non-smokers indicates passive smoking. Accurate measurement of nicotine among active and passive smokers can help in smoking cessation programs or programs designed to prevent secondhand smoke exposure. Read More

    Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients.
    Cancer Biomark 2017 Jul;20(1):23-29
    Organ Transplant Institute, Beijing, China.
    Objectives: The goal of our study was to assess the prognostic impact of the necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy in hepatocellular carcinoma (HCC) patients.

    Methods: In this study, expression of RIPK1 and its genetic polymorphism(rs2272990) were examined in plasma of 44 HCC patients. All these patients were undergoing partial hepatectomy. Read More

    Promoter hypermethylation of RAR-β tumor suppressor gene in gastric carcinoma: Association with histological type and clinical outcomes.
    Cancer Biomark 2017 Jul;20(1):7-15
    Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: While gastric cancer is a common cancer in the world and Iran, its molecular mechanisms are not fully understood as yet. Epigenetic modifications can lead to alteration of gene expression and development of tumorigenesis mechanisms.

    Methods: To clarify the difference in DNA methylation pattern of histological types in gastric carcinoma, CpG islands in the promoters of retinoic acid receptor β gene (RAR-β) was studied using methylation-specific PCR. Read More

    Chemokine receptor CXCR7 is an independent prognostic biomarker in glioblastoma.
    Cancer Biomark 2017 Jul;20(1):1-6
    Department of Neurology, Daqing Oilfield General Hospital, Daqing, Heilongjiang, China.
    Background: Glioblastoma (GBM) is the most common and most fatal primary brain cancer in adults. Due to the complex nature of GBM, its pathogenesis still remain unclear. Accumulating evidence suggest that chemokine receptor CXCR7 contribute to the development of various types of tumors. Read More

    FSTL1 contributes to tumor progression via attenuating apoptosis in a AKT/GSK-3β - dependent manner in hepatocellular carcinoma.
    Cancer Biomark 2017 Jul;20(1):75-85
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
    Background: Several investigations have demonstrated that follistatin-like 1 (FSTL1) is implicated in the initiation and progression of diverse cancers. It remains unclear whether FSTL1 acted as a cancer-promoting gene through its overexpression in HCC.

    Patients And Methods: We detected FSTL1 protein expression in 210 consecutive HCC cases curatively resected in our hospital between 2004 and 2007. Read More

    Thrombospondin-I concentrations behavior in plasma of patients with ovarian cancer.
    Cancer Biomark 2017 Jul;20(1):31-39
    Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
    Purpose: To determine whether thrombospondin-1 might be used as a prognostic factor in ovarian cancer patients.

    Method: Ninety-six female subjects hospitalized in years 2011-2014 was included in the study. Transvaginal ultrasound examination was performed in all patients. Read More

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