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    1034 results match your criteria Cancer Biomarkers [Journal]

    1 OF 21

    The potential predictive value of circulating immune cell ratio and tumor marker in atezolizumab treated advanced non-small cell lung cancer patients.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing, China.
    Background: The PD-L1 antibody atezolizumab has shown promising efficacy in patients with advanced non-small cell lung cancer. But the predictive marker of clinical benefit has not been identified.

    Objective: This study aimed to search for potential predictive factors in circulating blood of patients receiving atezolizumab. Read More

    miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells.
    Cancer Biomark 2018 May 5. Epub 2018 May 5.
    Department of Gynaecological Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China.
    Background: Interferon-α (IFN-α) is an adjuvant to chemotherapy and radiotherapy for hepatocellular carcinoma (HCC), but some HCC patients do not respond to treatment with IFN-α.

    Methods: We performed loss-of-function and gain-of-function experiments to examine the role of ISG15 in the IFN-α sensitivity of LH86, HLCZ01, SMMC7721, and Huh7 cell lines and tumor samples.

    Results: The overexpression of ISG15 reduced apoptosis in Huh7 and LH86 cells in the presence of IFN-α, whereas the shRNA-mediated knock down of ISG15 expression increased apoptosis in both Huh7 and LH86 cells. Read More

    MicroRNA-493 suppresses cell proliferation and invasion by targeting ZFX in human hepatocellular carcinoma.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital, Chinese People's Liberation Army, Kunming 650032, Yunnan, China.
    Backgrounds: MicroRNAs (miRNAs) are some RNA molecules that negatively regulate gene expression by binding to the 3'-untranslated region (3'-UTR) of target mRNA molecules. The aim of the study is to investigate the clinical role and functional effects of microRNA-493 (miR-493) in human hepatocellular carcinoma (HCC).

    Methods: Expression of miR-493 in 58 cases of HCC tissues and adjacent normal tissues was determined by using quantitative real-time PCR (qRT-PCR) analyses. Read More

    Epithelial-mesenchymal transition and GALC expression of circulating tumor cells indicate metastasis and poor prognosis in non-small cell lung cancer.
    Cancer Biomark 2018 May 5. Epub 2018 May 5.
    Background: Circulating tumor cells (CTCs) is a promising biomarker for cancer prognosis and monitoring. Molecular characterizing of CTCs could provide beneficial information on the basis of CTCs counting.

    Objective: To investigate the epithelial-mesenchymal transition (EMT) phenotypes and GALC mRNA expression of CTCs in non-small cell lung cancer (NSCLC) patients. Read More

    Plasma CCL5 promotes EMT-medicated epirubicin-resistance in locally advanced breast cancer.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 210029 Nanjing, Jiangsu, China.
    Neoadjuvant chemotherapy (NCT) is the standard treatment for locally advanced breast cancer (LABC). Pathological complete response (pCR) is commonly used as a valid predictor of NCT long-term outcomes. Blood-based tumor biomarkers have the potential to predict response to NCT at early stage non-invasively. Read More

    The emerging roles of long non-coding RNA in gallbladder cancer tumorigenesis.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
    Accumulating evidence suggests that long non-coding RNAs (lncRNAs) have important regulatory functions in gallbladder cancer (GBC) tumorigenesis and can serve as potential novel markers and/or targets for GBC. In this review, we critically discuss the emerging alteration of lncRNAs in GBC, the lncRNAs induced epigenetic regulation, the interaction of lncRNAs with microRNAs and lncRNAs effects on tumor-related signaling pathways. Additionally, contributions of lncRNAs in epithelial-mesenchymal transition process and energy metabolism reprogramming in GBC are also addressed. Read More

    The roles of CD133 expression in the patients with non-small cell lung cancer.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Department of Cell Biology, College of Basic Medical Science, and Biological Anthropology Institute, Liaoning Medical University, Jinzhou, Liaoning, China.
    Background: This study was carried out to investigate the correlation between CD133 and non-small cell lung cancer (NSCLC) clinicopathological features and its impact on survival of the patients with NSCLC.

    Methods: In the first, we detected the level and localization of CD133 protein in NSCLC specimens and confirmed that CD133 expression was closely linked to poor prognosis of NSCLC. Secondly, TCGA genomic data for LUNG (Provisional) was retrieved and analyzed for genetic alterations of CD133 in different lung cancer subtypes. Read More

    Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients.
    Cancer Biomark 2018 May 5. Epub 2018 May 5.
    Department of Emergency Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    Background: Rap1GAP, a member of the family of GTPase-activating proteins, is reported to be involved in cancer development and progression.

    Objective: The study aimed to investigate the expression and prognostic value of Rap1GAP in gastric cancer patients.

    Methods: Real-time quantitative polymerase chain reaction and western blotting were performed to examine Rap1GAP expression in tumorous and matched adjacent non-tumorous gastric tissues. Read More

    Upregulation of SNHG3 expression associated with poor prognosis and enhances malignant progression of ovarian cancer.
    Cancer Biomark 2018 May 4. Epub 2018 May 4.
    Department of Gynecology and Obstetrics, Zhujiang Hospital,Southern Medical University, Guangzhou, Guangdong, China.
    Background: Aberrant expression of long non-coding RNAs is involved in the progression of ovarian cancer. However, the clinical significance and biological functions of SNHG3 expression was little known in ovarian cancer (OC).

    Methods: The SNHG3 expression in ovarian cancer tissues and paired adjacent normal tissues was detected using quantitative real time polymerase chain reaction (qRT-PCR). Read More

    ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study.
    Cancer Biomark 2018 Apr 7. Epub 2018 Apr 7.
    Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
    Purpose: Plasma and serum cell-free DNA (cfDNA) are useful sources of tumor DNA, but comparative investigations of the tumor mutational status between them are rare.

    Methods: we performed droplet digital PCR assay for representative hotspot mutations in metastatic breast cancer (MBC) (ESR1 and PIK3CA) in serum and plasma cfDNA concurrently extracted from the blood of 33 estrogen receptor-positive MBC patients.

    Results: ESR1 mutations in plasma cfDNA were found in 7 of the 33 patients; ESR1 mutations in serum cfDNA were detected in only one out of 7 patients with ESR1 mutations in plasma cfDNA. Read More

    A blood biomarker for monitoring response to anti-EGFR therapy.
    Cancer Biomark 2018 Apr 13. Epub 2018 Apr 13.
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
    Background And Objective: To monitor therapies targeted to epidermal growth factor receptors (EGFR) in non-small cell lung cancer (NSCLC), we investigated Peroxiredoxin 6 (PRDX6) as a biomarker of response to anti-EGFR agents.

    Methods: We studied cells that are sensitive (H3255, HCC827) or resistant (H1975, H460) to gefitinib. PRDX6 was examined with either gefitinib or vehicle treatment using enzyme-linked immunosorbent assays. Read More

    Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion.
    Cancer Biomark 2018 Apr 10. Epub 2018 Apr 10.
    Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
    Background: The role of adopokines in adrenal tumors' hormonal activity remains unclear. Obesity may induce arterial hypertension, disorders of carbohydrate metabolism, and is a risk factor of cardiovascular disease. In patients with subclinical hormone secretion by the adrenal cortex or medulla the risk of metabolic disease is increased. Read More

    MDR1 not CYP3A4 gene expression is the predominant mechanism of innate drug resistance in pediatric soft tissue sarcoma patients.
    Cancer Biomark 2018 Apr 13. Epub 2018 Apr 13.
    Laboratory of Genetic Toxicology, National Institute of Pediatrics, Mexico City, Mexico.
    Background: Intratumoral up-regulation of genes coding for drug transporters and metabolizing enzymes, such as MDR1 and CYP3A4, after chemotherapy are linked to cancer drug resistance. However their expression in primary soft tissue sarcomas (STS) prior to drug treatment and their role in innate resistance remain unclear.

    Objective: The aim of this study was characterize MDR1 and CYP3A4 expression pattern before to chemotherapy and its clinical implication in pediatric STS. Read More

    Serological TK1 predict pre-cancer in a routine health screenings of 56,178 people.
    Cancer Biomark 2018 Apr 6. Epub 2018 Apr 6.
    Sino-Swed Molecular Bio-Medicine Research Institute, Shenzhen, Guangdong, China.
    Background: People with biomarkers above cut-off values normally have higher risk to develop pre-malignancies and malignancies.

    Objective: Here we investigate if serological TK1 protein (STK1p), AFP, CEA and PSA below cut-off values predict development of pre-cancer.

    Methods: The mean values and the concentration distribution of STK1p, AFP, CEA and PSA were determined in a cohort of 56,178 persons participating a health screening group, consist of people with non-tumor diseases, pre-malignancy and diseases associated with the risk process of malignancy. Read More

    Low miR-192 expression predicts poor prognosis in pediatric acute myeloid leukemia.
    Cancer Biomark 2018 Apr 9. Epub 2018 Apr 9.
    Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China.
    Background: Abnormal expression of miR-192 has been observed in a variety of human cancers, but the expression pattern of miR-192 and its prognostic value in pediatric acute myeloid leukemia (AML) is poorly known.

    Objective: This study was to explore the expression status of miR-192 and its clinical significance in pediatric patients with AML.

    Methods: Quantitative RT-PCR was carried out to detect miR-192 expression level in the serum from 97 AML cases and 50 healthy controls. Read More

    Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma.
    Cancer Biomark 2018 Apr 9. Epub 2018 Apr 9.
    Clinic for Plastic and Hand Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Background: Liposarcoma constitute about 13% of all soft tissue sarcoma and are associated with a high risk of metastases. As the preoperative differentiation between benign and malign lipomatous tumors is restricted to magnetic resonance imaging, computed tomography and biopsy, we performed a miRNA array to distinguish dedifferentiated liposarcoma patients from healthy controls and lipoma patients.

    Methods: Blood samples of patients with dedifferentiated liposarcoma, healthy controls and lipoma patients were collected. Read More

    Clinical biomarkers for cancer recognition and prevention: A novel approach with optical measurements.
    Cancer Biomark 2018 Apr 6. Epub 2018 Apr 6.
    Department of Medical Biotechnologies, University of Siena, Siena, Italy.
    Cancer is the most important cause of death worldwide, and early cancer detection is the most fundamental factor for efficacy of treatment, prognosis, and increasing survival rate. Over the years great effort has been devoted to discovering and testing new biomarkers that can improve its diagnosis, especially at an early stage. Here we report the potential usefulness of new, easily applicable, non-invasive and relatively low-cost clinical biomarkers, based on abnormalities of oral mucosa spectral reflectance and fractal geometry of the vascular networks in several different tissues, for identification of hereditary non-polyposis colorectal cancer carriers as well for detection of other tumors, even at an early stage. Read More

    No evidence of pancreatic ductal adenocarcinoma specific autoantibodies to Ezrin in a liquid phase LIPS immunoassay.
    Cancer Biomark 2018 Apr 3. Epub 2018 Apr 3.
    Division of Genetics and Cell Biology, Genomic Unit for the Diagnosis of Human Pathologies, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
    Background: Sensitive and specific biomarkers of Pancreatic Ductal Adenocarcinoma (PDAC) are desperately needed to allow early diagnosis and improve patient's survival. Ezrin autoantibodies were recently described as present in 93% of PDAC patients and 40% of healthy subjects who later developed PDAC. However, another prospective study failed to replicate these findings. Read More

    Decreased BRMS1L expression is correlated with glioma grade and predicts poor survival in glioblastoma via an invasive phenotype.
    Cancer Biomark 2018 Apr 2. Epub 2018 Apr 2.
    Aims: To evaluate the prognostic and clinicopathological features of glioma with BRMS1L expression.

    Methods: Total 120 glioma samples were obtained as discovery cohort. CGGA, GSE and TCGA datasets were obtained as validation sets. Read More

    Plasma exosome levels in non-small-cell lung cancer: Correlation with clinicopathological features and prognostic implications.
    Cancer Biomark 2018 Apr 3. Epub 2018 Apr 3.
    Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, China.
    Background: Biomarker studies revealed important clinical significance of exosome for cancer patients. However, there is currently no consensus on exosome quantification methods.

    Methods: Bicinchoninic acid (BCA) method, acetylcholinesterase (AChE) method and nanoparticle tracking analysis (NTA) were utilized to quantify 20 plasma exosome samples, and interrelations between these three methods were explored. Read More

    Down-regulation of long non-coding RNA GAS5-AS1 and its prognostic and diagnostic significance in hepatocellular carcinoma.
    Cancer Biomark 2018 Apr 2. Epub 2018 Apr 2.
    Department of Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.
    Background: Hepatocellular carcinoma (HCC) is the most common solid tumor in global range, with high degree of malignancy and poor prognosis. But the relationship between the expression of GAS5-AS1 and HCC is not documented. This study aimed to profile GAS5-AS1 expression signature and then to explore its clinical significance in HCC. Read More

    MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma.
    Cancer Biomark 2018 ;22(1):151-159
    Department of Intensive Care Unit, First Hospital of Jilin University, Changchun, Jilin, China.
    Objectives: MicroRNAs (miRNAs) were identified to be involved in various biological functions by regulating the degradation or suppressing the translation of their downstream target genes. Recent studies have identified miR-29a acts as tumor suppressor in hepatocellular carcinoma (HCC) progression. However, the underlying functions for miR-29a in HCC still to be investigated. Read More

    Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis.
    Cancer Biomark 2018 ;22(1):135-142
    Department and Program of Clinical Laboratory Medicine, Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.
    Background: Circular RNAs (circRNA)are involved in the progression of cancers, and previous study showed that hsa_circ_0001649 expression is down-regulated in hepatocellular carcinoma (HCC).

    Objective: To explore whether hsa_circ_0001649 is a prognostic biomarker for HCC and to investigate the biological functions of hsa_circ_0001649 in HCC.

    Methods: Hsa_circ_0001649 expression was measured in 77 pairs of HCC and adjacent no-tumor tissues by quantitative Real-Time polymerase chain reaction. Read More

    Diagnostic and prognostic implications of serum miR-101 in osteosarcoma.
    Cancer Biomark 2018 ;22(1):127-133
    Departments of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
    Blood-circulating microRNAs (miRNAs) have been reported to be used as potential biomarkers in various cancers. MiR-101 has been found to act as a tumor suppressor in many tumor types, but little is known for osteosarcoma. The purpose of this study was to investigate miR-101 expression in osteosarcoma patients and assess its correlation with clinical features and prognosis. Read More

    Serum miR-658 induces metastasis of gastric cancer by activating PAX3-MET pathway: A population-based study.
    Cancer Biomark 2018 ;22(1):111-118
    Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
    Background And Objective: MiR-658, paired box gene 3 (PAX3) and met proto-oncogene (MET) are overexpressed in gastric cancer while PAX3 and MET can be regulated by miRNA. Serum miR-658 may be associated with metastasis of gastric cancer (MGC) by affecting PAX3-MET pathway.

    Methods: Ninety-eight gastric carcinoma patients with distant MGC (DM group) and ninety-six gastric carcinoma patients with no MGC (NM group) were recruited. Read More

    MicroRNA profiles as predictive markers of response to azacitidine therapy in myelodysplastic syndromes and acute myeloid leukemia.
    Cancer Biomark 2018 ;22(1):101-110
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
    Background: Azacitidine (AZA) is a nucleoside analog used for treatment of myelodysplasia and the prediction of AZA responsiveness is important for the therapy management.

    Methods: Using microarrays and reverse-transcription quantitative-PCR, we analyzed microRNA (miRNA) expression in bone marrow CD34+ cells of 27 patients with higher-risk myelodysplastic syndromes or acute myeloid leukemia with myelodysplasia-related changes before and during AZA treatment.

    Results: At baseline, we found that future overall response rate was significantly higher in patients with upregulated miR-17-3p and downregulated miR-100-5p and miR-133b. Read More

    Elevated MACC1 expression predicts poor prognosis in small invasive lung adenocarcinoma.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
    Background: Patients with small (⩽ 2 cm) invasive lung adenocarcinoma are at high risk of poor prognosis and disease recurrence after complete surgical resection. Therefore, identification of high-risk individuals from these patients emerges as an urgent problem. Elevated MACC1 expression predicts a poor prognosis in multiple types of cancer that are independent of TNM staging. Read More

    Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Background: LncRNA and microRNA play an important role in the development of human cancers; they can act as a tumor suppressor gene or an oncogene. LncRNA GAS5, originating from the separation from tumor suppressor gene cDNA subtractive library, is considered as an oncogene in several kinds of cancers. The expression of miR-221 affects tumorigenesis, invasion and metastasis in multiple types of human cancers. Read More

    Phytochemical and anti-inflammatory activities of aqueous leaf extract of Indian borage (oregano) on rats induced with inflammation.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Department of Chemical Pathology, University of Benin Teaching Hospital, Benin, Edo State, Nigeria.
    Background: The Indian borage (Plectranthus amboinicus) also called Oregano contains many effective antioxidants, which includes caffeic acid, rosmarinic acid and flavonoids. It has been employed in traditional medicine for its several health benefits including the prevention and cure of many debilitating diseases. Anti-inflammatory properties of Plectranthus amboinicus grown within this environment have not been adequately explored. Read More

    Prognostic value of baseline carcinoembryonic antigen and cytokeratin 19 fragment levels in advanced non-small cell lung cancer.
    Cancer Biomark 2018 ;22(1):55-62
    Division of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, College of Medicine, Soonchunhyang University, Wonmi-gu, Bucheon-si, Gyeonggi-do, Korea.
    Background: Serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) levels are prognostic predictors in non-small cell lung cancer (NSCLC). However, even in patients with the same stage of cancer, the serum levels of those markers often vary.

    Objective: We investigated the association between the initial biomarker levels and prognosis. Read More

    Circulating HOTAIR expression predicts the clinical response to neoadjuvant chemotherapy in patients with breast cancer.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Tianhe District, Guangzhou, Guangdong, China.
    Background: Long noncoding RNA HOTAIR has been detected in the serum of patients with various malignances and may be served as novel biomarker for diagnosis and prognosis prediction of breast cancer. However, the value of circulating HOTAIR to predict the response to neoadjuvant chemotherapy (NAC) remains unclear.

    Objective: In the present study, we analyzed whether pretreatment circulating HOTAIR levels predict the response to NAC and investigated prognostic impact of circulating HOTAIR on disease-free survival (DFS) in breast cancer patients treated with NAC. Read More

    LncRNA SNHG12 promotes the proliferation and metastasis of papillary thyroid carcinoma cells through regulating wnt/β-catenin signaling pathway.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
    Objective: To investigate the expression and role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 12 (SNHG12) in papillary thyroid carcinoma (PTC).

    Methods: The relative expression levels of lncRNA SNHG12 (hereinafter referred to as SNHG12) in 42 pairs of PTC tissues and para-carcinoma tissues were detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR). SNHG12 specific interference sequences were designed and synthesized. Read More

    Inhibition of E-cadherin expression by lnc-RNA H19 to facilitate bladder cancer metastasis.
    Cancer Biomark 2018 Mar 19. Epub 2018 Mar 19.
    Department of Urological Surgery, The People's Hospital of Jiangxi, Nanchang 330006, Jiangxi, China.
    Bladder cancer is derived from bladder mucosa and is the most common malignant tumor in urinary system. Long non-coding RNA (lnc-RNA) has high tissue specificity and can participate in cell proliferation and differentiation at various levels, and plays critical roles in occurrence of malignant tumors. This study aims to investigate the suppression of E-cadherin expression by lnc-RNA H19 to enhance bladder cancer metastasis. Read More

    Baicalein suppresses non small cell lung cancer cell proliferation, invasion and Notch signaling pathway.
    Cancer Biomark 2018 ;22(1):13-18
    Department of Surgery, Boshan District Hospital of Traditional Chinese Medicine, Zibo 255200, Shandong, China.
    Background: Baicalein is an important Chinese herbal medicine and has multiple pharmacological activities. However, the biological mechanisms of the anti-tumor effects of Baicalein on non small cell lung cancer (NSCLC) still need to be understood.

    Methods: Human NSCLC A549 and H1299 cells were pretreated with Baicalein or DMSO. Read More

    Lower serum CA125 level, negative vascular invasion, and wild BRAF were strongly associated with better 2-year disease-free survival in patients with stage III colorectal cancer who received adjuvant chemotherapy.
    Cancer Biomark 2018 ;22(1):161-168
    Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China.
    Background: Adjuvant chemotherapy plays important role in the comprehensive treatment of patients with stage III colorectal cancer. However, there is few molecular markers for predicting the therapeutic effect.

    Objective: To identify factors that could predict adjuvant chemotherapy benefits in patients with stage III colorectal cancer. Read More

    Is serum survivin expression a predictive biomarker in locally advanced gastric cancer patients treated with neoadjuvant chemotherapy?
    Cancer Biomark 2018 ;22(1):143-149
    Department of Medical Oncology, SBÜ Ankara Numune Education and Research Hospital, Ankara, Turkey.
    Background: The potential prognostic value of survivin is variably reported depending on the gastric cancer.

    Objective: Evaluation of the prognostic and predictive significance of serum survivin and its relation with survival and treatment response rates in patients with locally advanced gastric cancer (LAGC).

    Methods: Serum samples were prospectively collected from 50 patients with newly diagnosed LAGC. Read More

    Down-regulated serum miR-126 is associated with aggressive progression and poor prognosis of gastric cancer.
    Cancer Biomark 2018 ;22(1):119-126
    Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
    Background: miR-126 functions as a tumor suppressor in gastric cancer (GC), however, the clinical significance of serum miR-126 in GC remains unclear.

    Objective: To investigate the associations of serum miR-126 level with the clinicopathological characteristics and prognosis of GC patients.

    Methods: Quantitative real-time polymerase chain reaction was performed to examine the expression levels of miR-126 in 338 GC patients' tissues and sera, and 50 healthy controls' sera. Read More

    Potential biomarkers for the early diagnosis of colorectal adenocarcinoma - transcriptomic analysis of four clinical stages.
    Cancer Biomark 2018 ;22(1):89-99
    Chair and Clinical Department of General, Colorectal and Trauma Surgery, Medical University of Silesia, Sosnowiec, Poland.
    Backgrounds: Colorectal cancer is the third most common cancer in economically developed countries. Molecular studies and, in particular, gene expression have contributed to advances in the diagnosis and treatment of many cancers. Genes can be molecular and therapeutic markers, but because of the large molecular diversity in colorectal cancer the knowledge is not yet fully established. Read More

    MicroRNA-136 functions as a tumor suppressor in osteosarcoma via regulating metadherin.
    Cancer Biomark 2018 ;22(1):79-87
    Department of Orthopedic Oncology, Hangzhou Cancer Hospital, Hangzhou 310002, Zhejiang, China.
    Background: Accumulating studies have reported the abnormal expression of microRNA-136 (miR-136) in numerous types of human cancer, and its involvement in cancer initiation and progression. However, there are no investigations of miR-136 in osteosarcoma (OS).

    Objective: To explore the expression pattern, clinical significance and potential roles of miR-136 in OS. Read More

    Evaluation of neutrophil-to-lymphocyte ratio in newly diagnosed patients receiving borte- zomib-based therapy for multiple myeloma.
    Cancer Biomark 2018 ;22(1):43-48
    Background: The neutrophil-to-lymphocyte ratio (NLR) at diagnosis has been identified as an independent prognostic marker in several malignancies. Recently, a few studies have reported that an elevated pretreatment NLR is associated with poor survival among multiple myeloma (MM) patients. However, the role of NLR at diagnosis in patients with MM treated with regimens containing bortezomib has been less explored. Read More

    Predictive gene signatures of nodal metastasis in papillary thyroid carcinoma.
    Cancer Biomark 2018 ;22(1):35-42
    Background: Cervical lymph node metastases (LNM) in papillary thyroid carcinomas (PTCs) are common and develop in approximately 30-80% of PTCs. The presence of cervical LNM significantly increases the rate of locoregional recurrence in PTCs.

    Objective: To search for predictive gene signatures for nodal metastasis in PTCs. Read More

    The study of sclareol in inhibiting proliferation of osteosarcoma cells by apoptotic induction and loss of mitochondrial membrane potential.
    Cancer Biomark 2018 ;22(1):29-34
    Department of Bone Surgery, Zoucheng People's Hospital, Zoucheng, Shandong, China.
    Sclareol (sclarcol) is an organic compound extracted from sage clary plants. Recent study has showed its anti-tumor effects against breast cancer, gastric carcinoma, osteosarcoma and colorectal cancer. However, its exact mechanisms in inhibiting tumor growth remain unknown. Read More

    Aberrant expression of miR-141 and nuclear receptor small heterodimer partner in clinical samples of prostate cancer.
    Cancer Biomark 2018 ;22(1):19-28
    Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran.
    Background: Prostate cancer (PCa) is the second most common cancer in men worldwide. Currently, prostate-specific antigen (PSA) test and digital rectal exam are the main screening tests used for PCa diagnosis. However, due to the low specificity of these tests, new alternative biomarkers such as deregulated RNAs and microRNAs have been implemented. Read More

    Combining ctnnb1 genetic variability with epidemiologic factors to predict lung cancer susceptibility.
    Cancer Biomark 2018 ;22(1):7-12
    Cancer and Stem Cell Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, China.
    Objective: Early detection and diagnosis of lung cancer remain challenging but would improve patient prognosis. The goal of this study is to develop a model to estimate the risk of lung cancer for a given individual.

    Methods: We conducted a case-control study to develop a predictive model to identify individuals at high risk for lung cancer. Read More

    Smac combined with DDP can inhibit drug resistance of ovarian cancer through regulation of Survivin expression.
    Cancer Biomark 2018 ;22(1):1-6
    Ovarian cancer has the highest mortality rate among gynecological malignancies, presenting a major threat to women's life and health. It is essential to study the mechanisms of drug resistance to chemotherapy to identify ways to enhance drug-sensitivity. In recent years, many studies have shown that Smac/DIABLO is closely related to tumor drug resistance. Read More

    LncRNA AB209630 inhibits gemcitabine resistance cell proliferation by regulating PI3K/AKT signaling in pancreatic ductal adenocarcinoma.
    Cancer Biomark 2018 ;22(1):169-174
    Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
    Background: Recent study revealed that abnormal long noncoding RNAs (lncRNAs) expression are association with chemotherapy resistance of pancreatic ductal adenocarcinoma (PDAC).

    Objective: The present study was aimed to investigate the effects of lncRNA AB209630 expression for gemcitabine resistance in PDAC cells.

    Methods: In the study, increased expression of lncRNA AB209630 could suppress cell proliferation and cell colony formation ability in gemcitabine resistance cells of PDAC. Read More

    The expression of CCL18 in diffuse large B cell lymphoma and its mechanism research.
    Cancer Biomark 2018 ;21(4):925-934
    Background: Molecular target therapy has become a hot spot in cancer treatment, finding effective targets for diffuse large B cell lymphoma (DLBCL) is an urgent problem.

    Objective: To detect the expression level of C-C motif chemokine ligand 18 (CCL18) in DLBCL and clarify its potential role in the progression of DLBCL.

    Methods: Gene expression datas of DLBCL were obtained from TCGA and GEO databases. Read More

    Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.
    Cancer Biomark 2018 ;21(4):883-891
    Endocrinology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Background: Epidemiological data have revealed that colorectal cancer (CRC) risk is increased in patients with Metabolic syndrome.

    Objective: To explore the expressions of IGF-1, ERK, GLUT4, IRS-1 in MS patients with CRC and their associations with the clinical characteristics of CRC.

    Methods: We investigated the expressions of IGF-1, ERK, GLUT4 and IRS-1 in greater omental adipose tissues of 168 MS patients with/without CRC, 85 CRC patients without MS and 98 healthy controls by RT-PCR, and analyzed the relationships between their expressions and clinical characteristics of CRC. Read More

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