253,894 results match your criteria Cancer Biology & Therapy [Journal]


Biosynthesized of reduced graphene oxide nanosheets and its loading with paclitaxel for their anti cancer effect for treatment of lung cancer.

J Photochem Photobiol B 2018 Nov 22;191:13-17. Epub 2018 Nov 22.

Department of pharmacy, Fujian Provincial Hospital& Fujian Medical University, People's Republic of China; Molecular Biology Laboratory of Chinese Traditional Medicine, Fujian Provincial Hospital, People's Republic of China. Electronic address:

Multifunctional nanocarriers are in immediate need to develop anticancer activity for the treatment of cancers. In the present research, the graphene oxide was reduced via an efficient method which reduced to RGO by using Euphorbia milii leaves extract. Thus obtained RGO nanocomposites were subsequently characterized by means UV-Vis absorption technique. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.11.015DOI Listing
November 2018

Mechanistic modelling of Radium-223 treatment of bone metastases.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.

Introduction: Despite the effectiveness of RaCl for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions. In silico tumour models bring a new perspective to this as they can quantitatively simulate the interaction of α-particles with the target(s). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.015DOI Listing
December 2018
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Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, 3060-197, Cantanhede, Portugal. Electronic address:

Dose-dependent and cumulative cardiotoxicity associated with doxorubicin (DOX) is the main limitation of anticancer therapy. Pediatric cancer survivors are particularly vulnerable, and no effective prevention measures are available. The aim of the present study was to investigate the persistent effects of nanomolar DOX concentrations and determine whether a pretreatment would induce mitochondrial adaptations in H9c2 cardiomyoblasts. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.017DOI Listing
December 2018

Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Proteomics Research and Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School and Cancer Institute of New Jersey, Newark, NJ 07103, USA. Electronic address:

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for accurate identification of SS. Even though several mass spectrometry methods have emerged for this task, their practical use rests on the broad effectiveness of both sample preparation methods and bioinformatics tools. Read More

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http://dx.doi.org/10.1016/j.jprot.2018.12.010DOI Listing
December 2018

Induced Pluripotent Stem Cells: A New Strategy to Model Human Cancer.

Int J Biochem Cell Biol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory for Cancer Biology, Department of Medical Oncology and Clinical Research, Cancer Institute (WIA), Chennai, India. Electronic address:

Induced pluripotent stem cells are derived from adult somatic cells by ectopic expression of stem cell factors OCT4, SOX2, MYC and KLF4. These cells have characteristic features similar to embryonic stem cells. Although there exists in vitro and in vivo models of cancer, recapitulating the earliest events in the pathogenesis remain challenging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13572725183026
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http://dx.doi.org/10.1016/j.biocel.2018.12.008DOI Listing
December 2018
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TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells.

Cell Signal 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Genes Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:

High level expression of lipocalin 2 (LCN2) usually indicates poor prognosis in esophageal squamous cell carcinoma (ESCC) and many other cancers. Our previous study showed LCN2 promotes migration and invasion of ESCC cells through a novel positive feedback loop. However, the key transcription activation protein (KTAP) in the loop had not yet been identified. Read More

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http://dx.doi.org/10.1016/j.cellsig.2018.12.007DOI Listing
December 2018

Analysing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Proteomics 2018 Dec 17:e1800176. Epub 2018 Dec 17.

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host-microorganism relationship or they may even serve as useful biomarkers for CRC. Read More

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http://doi.wiley.com/10.1002/pmic.201800176
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http://dx.doi.org/10.1002/pmic.201800176DOI Listing
December 2018
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Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells.

PLoS One 2018 17;13(12):e0208756. Epub 2018 Dec 17.

Department of Biochemical, Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia, United States of America.

Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is differentially expressed in metabolism associated diseases, such as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS, we discovered that RARRES1 depletion in epithelial cells caused a global increase in lipid synthesis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208756PLOS
December 2018

Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1.

PLoS One 2018 17;13(12):e0209096. Epub 2018 Dec 17.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Genome-wide association studies (GWAS) have identified greater than 30 variants associated with ovarian cancer, but most of these variants were investigated in European populations. Here, we integrated GWAS and subsequent functional analyses to identify the genetic variants with potential regulatory effects. We conducted GWAS for ovarian cancer using 681 Japanese cases and 17,492 controls and found that rs137672 on 22q13. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209096PLOS
December 2018
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Cell-intrinsic regulation of peripheral memory-phenotype T cell frequencies.

PLoS One 2018 17;13(12):e0200227. Epub 2018 Dec 17.

National Institute of Immunology, New Delhi, India.

Memory T and B lymphocyte numbers are thought to be regulated by recent and cumulative microbial exposures. We report here that memory-phenotype lymphocyte frequencies in B, CD4 and CD8 T-cells in 3-monthly serial bleeds from healthy young adult humans were relatively stable over a 1-year period, while Plasmablast frequencies were not, suggesting that recent environmental exposures affected steady state levels of recently activated but not of memory lymphocyte subsets. Frequencies of memory B and CD4 T cells were not correlated, suggesting that variation in them was unlikely to be determined by cumulative antigenic exposures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200227PLOS
December 2018

Identification of long intergenic non-coding RNAs (lincRNAs) deregulated in gastrointestinal stromal tumors (GISTs).

PLoS One 2018 17;13(12):e0209342. Epub 2018 Dec 17.

Institute for Digestive Research, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Long intergenic non-coding RNAs (lincRNAs) are >200 nucleotides long non-coding RNAs, which have been shown to be implicated in carcinogenic processes by interacting with cancer associated genes or other non-coding RNAs. However, their role in development of rare gastrointestinal stromal tumors (GISTs) is barely investigated. Therefore, the aim of this study was to define lincRNAs deregulated in GIST and find new GIST-lincRNA associations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209342PLOS
December 2018
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Correlation Between Pathologic Complete Response in the Breast and Absence of Axillary Lymph Node Metastases After Neoadjuvant Systemic Therapy.

Ann Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands.

Objective: The aim was to investigate whether pathologic complete response (pCR) in the breast is correlated with absence of axillary lymph node metastases at final pathology (ypN0) in patients treated with neoadjuvant systemic therapy (NST) for different breast cancer subtypes.

Background: Pathologic complete response rates have improved on account of more effective systemic treatment regimens. Promising results in feasibility trials with percutaneous image-guided tissue sampling for the identification of breast pCR after NST raise the question whether breast surgery is a redundant procedure. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003126DOI Listing
December 2018
8.327 Impact Factor

Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation.

Int J Radiat Biol 2018 Dec 17:1-44. Epub 2018 Dec 17.

a Disease control and homeostasis , Kanazawa University , 13-1 Takara-machi , Kanazawa , 920-8641 , Japan .

Background: Radiation therapy is an important alternative treatment for advanced cancer. The aim of the current study was to disclose distinct alterations of the biological characteristics of gene expression features in pancreatic cancer cells, MIAPaCa-2, following proton and X-ray irradiation.

Materials And Methods: Using cDNA microarray, we examined the gene expression alterations of MIAPaCa-2 cells following proton or X-ray irradiation. Read More

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http://dx.doi.org/10.1080/09553002.2019.1558297DOI Listing
December 2018

Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption.

FASEB J 2018 Dec 17:fj201801573R. Epub 2018 Dec 17.

Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga, Japan.

Osteoclasts derived from hematopoietic cells are activated on bone surface. To resorb bone, osteoclasts release acid and lysosome acid hydrolase via membrane transport. Prostate transmembrane protein androgen-induced (Pmepa)1 is a type I transmembrane protein that regulates proliferation, migration, and metastasis of cancer cells. Read More

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http://dx.doi.org/10.1096/fj.201801573RDOI Listing
December 2018

Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity.

Future Med Chem 2018 Dec 17;10(24):2855-2875. Epub 2018 Dec 17.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan 250012, PR China.

Hedgehog (HH) signaling pathway plays vital roles in controlling embryonic cell fate and homeostatic, and becomes dormant in mature individuals, aberrant activation of HH signaling pathway is involved in a number of human cancers. Smoothened (SMO), a vital transducer of HH signaling pathway, attracts significant attentions in HH signaling pathway-related cancer therapy. The approval of SMO antagonists vismodegib proves that SMO is a promising therapeutic target, and a number of SMO antagonists are reported since then. Read More

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http://dx.doi.org/10.4155/fmc-2018-0200DOI Listing
December 2018

Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs.

Elife 2018 Dec 17;7. Epub 2018 Dec 17.

Department of Biochemistry, Stanford University School of Medicine, Stanford, United States.

Extracellular vesicles mediate transfer of biologically active molecules between neighboring or distant cells, and these vesicles may play important roles in normal physiology and the pathogenesis of multiple disease states including cancer. However, the underlying molecular mechanisms of their biogenesis and release remain unknown. We designed artificially barcoded, exosomal microRNAs (bEXOmiRs) to monitor extracellular vesicle release quantitatively using deep sequencing. Read More

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http://dx.doi.org/10.7554/eLife.41460DOI Listing
December 2018

Integrating tumor genomics into studies of the microbiome in colorectal cancer.

Gut Microbes 2018 Dec 17:1-6. Epub 2018 Dec 17.

b Department of Genetics, Cell Biology, and Development , University of Minnesota , Minneapolis , MN , USA.

Although the gut microbiome has been linked to colorectal cancer (CRC) development, associations of microbial taxa with CRC status are often inconsistent across studies. We have recently shown that tumor genomics, a factor that is rarely incorporated in analyses of the CRC microbiome, has a strong effect on the composition of the microbiota. Here, we discuss these results in the wider context of studies characterizing interaction between host genetics and the microbiome, and describe the implications of our findings for understanding the role of the microbiome in CRC. Read More

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http://dx.doi.org/10.1080/19490976.2018.1549421DOI Listing
December 2018

UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways.

Proteomics 2018 Dec 17:e1800353. Epub 2018 Dec 17.

Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center, Shreveport, LA, 71130.

Uncoupling protein 2 (UCP2) is often upregulated in cancer cells. The UCP2 upregulation is positively correlated with enhanced proliferation, tumorigenesis, and metabolic alterations, thus suggesting that UCP2 upregulation could play a key role in sensing metabolic changes to promote tumorigenesis. To determine the global metabolic impact of UCP2 upregulation, we used C glucose as a source molecule to 'trace' the metabolic fate of carbon atoms derived from glucose. Read More

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http://dx.doi.org/10.1002/pmic.201800353DOI Listing
December 2018
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A six-gene assay as a new biomarker in the blood of patients with colorectal cancer: Establishment and clinical validation.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.

Colorectal cancer (CRC) is the second most common cancer in men and the third most common in women. Although long-term survival has improved over the past 30 years, at least 50% of patients with CRC will develop metastases after diagnosis. In this study, we examined whether quantifying the mRNAs of six CRC-related genes in the blood could improve disease assessment through detection of circulating tumor cells (CTCs), and thereby improve progression prediction in relapsed CRC patients. Read More

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http://doi.wiley.com/10.1002/1878-0261.12427
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http://dx.doi.org/10.1002/1878-0261.12427DOI Listing
December 2018
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ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Medicine, University of Freiburg, Germany.

A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of > 100 clinically-annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (p = 0. Read More

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http://dx.doi.org/10.1002/1878-0261.12426DOI Listing
December 2018

Vitamin E: Regulatory Role on Signal Transduction.

Authors:
Jean-Marc Zingg

IUBMB Life 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a hydrophobic molecule located mainly in membranes it contributes together with other lipids to the physical and structural characteristics such as membrane stability, curvature, fluidity, and the organization into microdomains (lipid rafts). By acting as the main lipid-soluble antioxidant, it protects other lipids such as mono- and poly-unsaturated fatty acids (MUFA and PUFA, respectively) against chemical reactions with reactive oxygen and nitrogen species (ROS and RNS, respectively) and prevents membrane destabilization and cellular dysfunction. Read More

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http://dx.doi.org/10.1002/iub.1986DOI Listing
December 2018

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Biology of Cancer, Medical University of Lodz, Poland.

We have extensively studied the phenotypic heterogeneity of patient-derived melanoma cells. Here, whole-exome sequencing revealed novel variants of genes associated with the MAPK, NOTCH, Hippo, cell-cycle, senescence and ubiquitin-dependent pathways, which could contribute to the observed phenotypic diversity between cell lines. Focusing on mutations in MAPK pathway-associated genes, we found BRAF (BRAF ) and RAS subtypes, including NRAS and the rare HRAS variant, and additional alterations potentially leading to different ERK1/2 activity. Read More

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http://dx.doi.org/10.1002/mc.22953DOI Listing
December 2018

Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-κB and p53.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Henan Key Laboratory of Plant Stress Biology, School of Life Science, Henan University, Kaifeng, China.

Long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been implicated as a tumor suppressor gene in several human cancer types. However, little is known regarding its involvement and potential mechanism in human breast cancer. In this study, we explored the effect of MEG3 on the growth of human breast cancer cell line MDA-MB-231 in vitro and in vivo, and sought to elucidate the potential signaling mechanisms. Read More

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http://dx.doi.org/10.1002/jcb.27982DOI Listing
December 2018

Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness.

J Physiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

Key Points: Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is expressed in skeletal muscle. Read More

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http://dx.doi.org/10.1113/JP276863DOI Listing
November 2018

The Extracellular Matrix of Ovarian Cortical Inclusion Cysts Modulates Invasion of Fallopian Tube Epithelial Cells.

APL Bioeng 2018 11;2(3). Epub 2018 Apr 11.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

A growing body of research supports the idea that the fallopian tube epithelium (FTE) is the precursor for most high-grade serous ovarian canacers (HGSOC) but that the ovary plays a critical role in tumor metastasis. Cortical inclusion cysts (CICs) in the ovarian cortex have been hypothesized to create a niche environment that plays a role in HGSOC progression. Through histological analysis of pathology samples from human ovaries, we determined that collagen I and III were elevated near CICs and that the collagen fibers in this dense region were oriented parallel to the cyst boundary. Read More

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http://dx.doi.org/10.1063/1.5022595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294138PMC

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells.

Hepatol Commun 2018 Dec 27;2(12):1583-1600. Epub 2018 Sep 27.

Division of Digestive and Liver Diseases, Department of Medicine Cedars Sinai Medical Center Los Angeles CA.

Prohibitin1 () is a mitochondrial chaperone with diverse functions that include cell proliferation, apoptosis, and mitochondrial homoeostasis. Liver-specific knockout (KO) mice develop spontaneous injury and hepatocellular carcinoma (HCC). Our previous work demonstrated that PHB1 negatively regulates the H19-insulin-like growth factor 2 (IGF2)-H19-IGF2 axis signaling pathway and E-box activity in hepatocytes and HCC cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep4.1257
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http://dx.doi.org/10.1002/hep4.1257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287485PMC
December 2018
1 Read

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatol Commun 2018 Dec 1;2(12):1567-1582. Epub 2018 Oct 1.

Laboratory of Metabolism National Cancer Institute, National Institutes of Health Bethesda MD.

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down-regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarcinogenesis has been documented. While global FXR deficiency in mice results in spontaneous HCC with aging, the contribution of tissue-specific FXR deficiency to hepatocarcinogenesis remains unclear. In this study, the prevalence of hepatic tumors, expression of genes related to tumorigenesis, and serum/liver BA levels were compared among male whole-body -null, hepatocyte-specific -null (), and enterocyte-specific -null () mice at the age of 3, 14, and 20 months. Read More

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http://dx.doi.org/10.1002/hep4.1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287584PMC
December 2018

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na-Taurocholate Cotransporting Polypeptide.

Hepatol Commun 2018 Dec 23;2(12):1550-1566. Epub 2018 Oct 23.

Amsterdam UMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.

Cholestasis-induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)-mediated transcriptional down-regulation of the bile acid importer Na-taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum (ER) stress. However, whether ER stress affects bile acid uptake is largely unknown. Here, we investigated the role of ER stress on the regulation and function of the bile acid transporter NTCP. Read More

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http://dx.doi.org/10.1002/hep4.1262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287483PMC
December 2018

Synthesis of Triazole-Substituted Quinazoline Hybrids for Anticancer Activity and a Lead Compound as the EGFR Blocker and ROS Inducer Agent.

ACS Omega 2018 Nov 28;3(11):16134-16142. Epub 2018 Nov 28.

Organic & Medicinal Chemistry Division, Academy of Scientific and Innovative Research (AcSIR), and Cancer Biology & Inflammatory Disorder, Indian Institute of Chemical Biology (CSIR-IICB), 4 Raja S. C. Mullick Road, Kolkata 700032, India.

A series of triazole-substituted quinazoline hybrid compounds were designed and synthesized for anticancer activity targeting epidermal growth factor receptor (EGFR) tyrosine kinase. Most of the compounds showed moderate to good antiproliferative activity against four cancer cell lines (HepG2, HCT116, MCF-7, and PC-3). Compound showed good antiproliferative activity (IC = 20. Read More

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http://dx.doi.org/10.1021/acsomega.8b01960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288807PMC
November 2018

Na-Montmorillonite-Dispersed Sustainable Polymer Nanocomposite Hydrogel Films for Anticancer Drug Delivery.

ACS Omega 2018 Nov 20;3(11):15809-15820. Epub 2018 Nov 20.

Material Research Laboratory, Department of Chemistry and Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.

Nanocomposite hydrogels have found a wide scope in regenerative medicine, tissue engineering, and smart drug delivery applications. The present study reports the formulations of biocompatible nanocomposite hydrogel films using carboxymethyl cellulose-hydroxyethyl cellulose-acrylonitrile-linseed oil polyol (CHAP) plain hydrogel and Na-montmorillonite (NaMMT) dispersed CHAP nanocomposite hydrogel films (NaCHAP) using solution blending technique. The structural, morphological, and mechanical properties of resultant nanocomposite hydrogel films were further investigated to analyze the effects of polyol and NaMMT on the characteristic properties. Read More

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http://dx.doi.org/10.1021/acsomega.8b01691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288778PMC
November 2018

Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation.

Sci Adv 2018 Dec 13;4(12):eaav8550. Epub 2018 Dec 13.

Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

As part of PsychENCODE, we developed a three-dimensional (3D) epigenomic map of primary cultured neuronal cells derived from olfactory neuroepithelium (CNON). We mapped topologically associating domains and high-resolution chromatin interactions using Hi-C and identified regulatory elements using chromatin immunoprecipitation and nucleosome positioning assays. Using epigenomic datasets from biopsies of 63 living individuals, we found that epigenetic marks at distal regulatory elements are more variable than marks at proximal regulatory elements. Read More

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http://dx.doi.org/10.1126/sciadv.aav8550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292713PMC
December 2018

The Oncogenic Functions of MASTL Kinase.

Front Cell Dev Biol 2018 23;6:162. Epub 2018 Nov 23.

ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia.

MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. In recent years MASTL has also emerged as a novel oncogenic kinase that is upregulated in a number of cancer types, correlating with chromosome instability and poor patient survival. Read More

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http://dx.doi.org/10.3389/fcell.2018.00162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282046PMC
November 2018

In vivo tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography.

Photoacoustics 2019 Mar 17;13:46-52. Epub 2018 Nov 17.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, 27101, United States.

While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal biodistribution. The goal of this study was to track orally administered particle uptake and trafficking through the murine gastrointestinal (GI) tract using multispectral optoacoustic tomography (MSOT). Polylactic acid (PLA) particles encapsulating AlexaFluor 680 (AF680) dye conjugated to bovine serum albumin (BSA) were orally gavaged into mice. Read More

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http://dx.doi.org/10.1016/j.pacs.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280634PMC

Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning.

Nat Biomed Eng 2018 Sep 23;2(9):666-674. Epub 2018 Jul 23.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

The identification of patients with aggressive cancer who require immediate therapy is a health challenge in low-income and middle-income countries. Limited pathology resources, high healthcare costs and large-case loads call for the development of advanced standalone diagnostics. Here, we report and validate an automated, low-cost point-of-care device for the molecular diagnosis of aggressive lymphomas. Read More

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http://dx.doi.org/10.1038/s41551-018-0265-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291220PMC
September 2018

Exosome mediated multidrug resistance in cancer.

Am J Cancer Res 2018 1;8(11):2210-2226. Epub 2018 Nov 1.

Department of Medical Oncology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China.

Extracellular vesicles (EVs), named as exosomes, were recently found to play important roles in cell-cell communication by transducing various biochemical and genetic information. Exosomes, secreted from either tumor cells or stromal cells including immune cells, can eventually remodel tumor environment to promote tumor progression such as metastasis and multidrug resistance (MDR). Therefore, the detection or targeting of biochemical and genetic cargos like proteins, lipids, metabolites and various types of RNAs or DNAs are believed to be valuable for the diagnosis and treatment of human cancer. Read More

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November 2018

Prolactin-induced protein (PIP)-characterization and role in breast cancer progression.

Am J Cancer Res 2018 1;8(11):2150-2164. Epub 2018 Nov 1.

Department of Human Morphology, Division of Histology and Embryology, Wroclaw Medical University Wroclaw, Poland.

Prolactin-induced protein (PIP) is a small secreted glycoprotein carrying several N-linked carbohydrate chains. The expression of PIP is generally restricted to cells with apocrine properties. It was found in apocrine glands of the axilla, vulva, eyelid, ear canal, and seminal vesicle. Read More

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November 2018

EZH2 as a therapeutic target for multiple myeloma and other haematological malignancies.

Biomark Res 2018 7;6:34. Epub 2018 Dec 7.

1Laboratory medicine program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, 11th floor, Toronto, ON M5G 2C4 Canada.

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is of great interest in human cancer. It has been shown to have a dual nature, as it can act as a gene repressor or activator. Studies have highlighted the various roles of EZH2 in the pathophysiology of multiple myeloma (MM). Read More

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http://dx.doi.org/10.1186/s40364-018-0148-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286605PMC
December 2018

HER-3 Knocking Down Induces G2/M Arrest in Gastric Cancer Cells.

Avicenna J Med Biotechnol 2018 Oct-Dec;10(4):227-232

Department of Biology, Faculty of Biological Sciences, Islamic Azad University, East Tehran Branch, Tehran, Iran.

Background: The Human Epidermal growth factor Receptor-3 (HER-3) is a member of ErbB receptor family and has deficient kinase activity. HER-3 should heterodimerize with other members of ErbB receptor family, especially with HER-2, to transduce downstream signaling pathways. HER-3 co-expresses with other ErbB receptors in different cancers and overexpresses while the oncogenic signaling pathways such as Jak/Stat, MAPK, and PI3K/Akt are activated and promoted. Read More

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December 2018

Water transport proteins-aquaporins (AQPs) in cancer biology.

Oncotarget 2018 Nov 20;9(91):36392-36405. Epub 2018 Nov 20.

H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.

As highly conserved ubiquitous proteins, aquaporins (AQPs) play an imperative role in the development and progression of cancer. By trafficking water and other small molecules, AQPs play a vital role in preserving the cellular environment. Due to their critical role in cell stability and integrity, it would make sense that AQPs are involved in cancer progression. Read More

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http://dx.doi.org/10.18632/oncotarget.26351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284741PMC
November 2018

The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast.

Oncotarget 2018 Nov 20;9(91):36358-36370. Epub 2018 Nov 20.

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.

Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific formation of phosphatidylinositol-4,5-bisphosphate (PI4,5P). By comparing normal breast tissue to carcinoma and invasive ductal carcinoma subtypes, we here show that the phosphorylation status of PIP5K1C at serine residue 448 (S448) can be predictive for breast cancer progression to an aggressive phenotype, while PIP5K1C expression levels are not indicative for this event. PIP5K1C phosphorylation at S448 is downregulated in invasive ductal carcinoma, and similarly, the expression levels of PKD1, the kinase that phosphorylates PIP5K1C at this site, are decreased. Read More

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http://dx.doi.org/10.18632/oncotarget.26357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284740PMC
November 2018

Prostaglandin E2 produced by myeloid-derived suppressive cells induces cancer stem cells in uterine cervical cancer.

Oncotarget 2018 Nov 20;9(91):36317-36330. Epub 2018 Nov 20.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Myeloid-derived suppressor cells (MDSCs) enhance tumor progression by suppressing tumor-specific T cell responses, stimulating tumor angiogenesis, or promoting tumor cell metastasis. However, the biology of MDSCs have not been fully investigated. In the current study, we investigated the role of MDSCs in inducing cancer stem-like cells and explored a clinically feasible approach for targeting MDSCs-mediated cancer stem-like cells induction. Read More

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http://dx.doi.org/10.18632/oncotarget.26347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284736PMC
November 2018

The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling.

Oncotarget 2018 Nov 20;9(91):36273-36288. Epub 2018 Nov 20.

University of Houston, Department of Biology and Biochemistry, Center for Nuclear, Receptors and Cell Signaling, Science and Engineering Research Center, Houston, Texas, USA.

Chemotherapy resistant prostate cancer is a major clinical problem. When the prostate cancer has become androgen deprivation resistant, one of the few treatment regimens left is chemotherapy. There is a strong connection between a cancer's stem cell like characteristics and drug resistance. Read More

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http://dx.doi.org/10.18632/oncotarget.26345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284737PMC
November 2018

Erratum: In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum.

Theranostics 2018 10;8(20):5660-5661. Epub 2018 Nov 10.

School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

[This corrects the article DOI: 10.7150/thno.19840. Read More

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http://dx.doi.org/10.7150/thno.31152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276290PMC
November 2018

Awakening p53 by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery.

Theranostics 2018 22;8(19):5320-5335. Epub 2018 Oct 22.

Center for Translational Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

Peptides are a rapidly growing class of therapeutics with many advantages over conventional small molecule drugs. Dextrorotary (D)-peptides, with increased enzymatic stability and prolonged plasma half-life in comparison with natural L-peptides, are considered to have great potential as recognition molecules and therapeutic agents. However, the efficacy of current therapeutic D-peptides is hindered by their inefficient cellular uptake in diseased tissues. Read More

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http://dx.doi.org/10.7150/thno.27165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276095PMC
October 2018

EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers.

Theranostics 2018 22;8(19):5307-5319. Epub 2018 Oct 22.

Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.

Epstein-Barr virus (EBV) infects more than 90% of humans worldwide and establishes lifelong latent infection in the hosts. It is closely associated with endemic forms of a wide range of human cancers and directly contributes to the formation of some. Despite its critical role in cancer development, no EBV- or EBV latent protein-targeted therapy is available. Read More

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http://dx.doi.org/10.7150/thno.26823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276081PMC
October 2018

miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer.

Cancer Manag Res 2018 29;10:6537-6547. Epub 2018 Nov 29.

Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China,

Background: Recent advances in cancer biology have uncovered critical roles for microRNAs in regulating tumor responses. This study is to elucidate the role of miR-424 in colorectal cancer development.

Materials And Methods: miR-424 expression was analyzed by qRT-PCR. Read More

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http://dx.doi.org/10.2147/CMAR.S185789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278700PMC
November 2018

Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α.

Onco Targets Ther 2018 29;11:8507-8515. Epub 2018 Nov 29.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China,

Purpose: Pancreatic cancer is characterized by a hypoxic microenvironment and resistance to most currently available treatment modalities. Prolyl hydroxylase domain 3 (PHD3) is a rate-limiting enzyme that regulates the degradation of hypoxia-inducible factors (HIFs) and is deregulated in pancreatic cancer cells. Whether such alteration of PHD3 expression contributes to the sustained growth and radioresistance of pancreatic cancer cells remains largely unknown. Read More

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http://dx.doi.org/10.2147/OTT.S187615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278705PMC
November 2018

Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis.

Int J Nanomedicine 2018 29;13:8137-8151. Epub 2018 Nov 29.

Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt,

Purpose: The objective of this study is to develop a facile tool for the absolute detection and quantification of nucleic acid transcripts, using a gold nanoparticle-based optical biosensor. Topoisomerase 1 (TOP1) and tyrosyl DNA phosphodiesterase 2 (TDP2) were among the nucleic acid transcripts of choice due to their role as genomic instability biomarkers and their implication in various cancers and neurologic disorders. This opens the door to develop a simple tool that can be used for diagnosing and monitoring treatment response for such diseases, overcoming the requirements for high cost, time, and complexity of the existing technologies for the absolute quantification of transcripts of interest. Read More

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http://dx.doi.org/10.2147/IJN.S181732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278840PMC
November 2018

A Self-degradable Curcumin Polymer with Anti-cancer Activity.

J Appl Polym Sci 2018 Dec 27;135(47). Epub 2018 Aug 27.

Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468.

Curcumin is a widely researched and utilized natural product used for a variety of ailments including as a gastrointestinal aide and an anticancer agent. Curcumin however suffers from poor bioavailability. A strategy to circumvent poor bioavailability is to administer with an adjuvant or by synthetic modification. Read More

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http://dx.doi.org/10.1002/app.46867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289511PMC
December 2018

HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia.

Leukemia 2018 Dec 16. Epub 2018 Dec 16.

Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

Achieving a deep molecular response (DMR) to tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukemia (CML) remains challenging and at present, there is no biomarker to predict DMR in this setting. Herein, we report that an HMGCLL1 genetic variant located in 6p12.1 can be used as a predictive genetic biomarker for intrinsic sensitivity to imatinib (IM) therapy. Read More

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http://www.nature.com/articles/s41375-018-0321-8
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http://dx.doi.org/10.1038/s41375-018-0321-8DOI Listing
December 2018
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