4,084 results match your criteria Cancer Biol. Ther.[Journal]


Silencing the intestinal GUCY2C tumor suppressor axis requires loss of heterozygosity.

Cancer Biol Ther 2020 Jun 28:1-7. Epub 2020 Jun 28.

Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia, PA, USA.

Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli () tumor suppressor gene, while germline heterozygosity for mutant produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of heterozygosity (LOH) silences the remaining normal allele of , through an unknown mechanism, as the initiating step in transformation. Guanylyl cyclase C receptor (GUCY2C) and its hormones, uroguanylin and guanylin, have emerged as a key signaling axis opposing mutations driving intestinal tumorigenesis. Read More

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http://dx.doi.org/10.1080/15384047.2020.1779005DOI Listing

MiR-185-3p mimic promotes the chemosensitivity of CRC cells via AQP5.

Cancer Biol Ther 2020 Jun 26:1-9. Epub 2020 Jun 26.

Department of Gastrointestinal Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang Province, China.

Background: Studies showed that microRNAs (miRNAs) are important regulators in drug resistance. The current study investigated the role of miR-185-3p and its predicted target gene AQP5 in 5-FU-insensitive colorectal cancer (CRC) cells.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and Spearman's correlation analysis were conducted to determine the correlation of expression levels of miR-185-3p and AQP5 from CRC tissues. Read More

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http://dx.doi.org/10.1080/15384047.2020.1761238DOI Listing

Dysregulated circRNA_100876 contributes to proliferation and metastasis of colorectal cancer by targeting microRNA-516b (miR-516b).

Cancer Biol Ther 2020 Jun 21:1-8. Epub 2020 Jun 21.

Department of Medical Laboratory, Wuwei People's Hospital , Wuwei, Gansu Province, China.

Colorectal cancer (CRC) is globally one of the most common malignant tumors. Increasing number of studies indicate that circular RNAs (circRNAs) play a significant role in the initiation and progression of CRC. However, the role of circRNA_100876 in CRC progression remains unclear. Read More

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http://dx.doi.org/10.1080/15384047.2020.1776075DOI Listing

Third-line sunitinib treatment in a -mutated metastatic intrahepatic cholangiocarcinoma: a case report and literature review.

Cancer Biol Ther 2020 Jun 18:1-5. Epub 2020 Jun 18.

Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, P.R. China.

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy with a poor prognosis. There is no standard treatment beyond first-line chemotherapy and no molecular-targeted drug approved for advanced iCCA. We herein present a case of a 46-y-old Asian iCCA patient with multiple metastases in lung, bone, and liver. Read More

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http://dx.doi.org/10.1080/15384047.2020.1769418DOI Listing

LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma.

Cancer Biol Ther 2020 Jun 16:1-9. Epub 2020 Jun 16.

Department of Neurology, China-Japan Union Hospital of Jilin University , Changchun, Jilin, China.

Glioma is the most prevalent brain malignancy with high mortality. In recent decades, the regulatory role of long noncoding RNAs (lncRNAs) has been unmasked in glioma. In this study, we focused on the function and mechanism of LINC00641 in glioma. Read More

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http://dx.doi.org/10.1080/15384047.2020.1776581DOI Listing

Clinical implication and usefulness of de novo EGFR T790M mutation in lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutation.

Cancer Biol Ther 2020 Jun 16:1-8. Epub 2020 Jun 16.

Department of Internal Medicine, Yonsei University College of Medicine , Seoul, Republic of Korea.

In total, 102 cases diagnosed as lung adenocarcinoma with EGFR-tyrosine kinase inhibitor (TKI) sensitizing mutations (mEGFR) and had been treated with 1 ~ 2 generation EGFR-TKI alone were enrolled for this study. De novo T790 M status was tested using the tissues at the initial diagnosis and positivity was defined as the ratio of T790 M/wild-type copies over 0.00294 by ddPCR. Read More

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http://dx.doi.org/10.1080/15384047.2020.1776579DOI Listing

Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells.

Cancer Biol Ther 2020 Jun 3:1-11. Epub 2020 Jun 3.

Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College , Bengbu, Anhui Province, China.

Non-small cell lung cancer (NSCLC) remains recalcitrant to effective treatment due to tumor relapse and acquired resistance. Cancer stem cells (CSCs) are believed to be one mechanism for relapse and resistance and are consequently considered promising drug targets. We report that chetomin, an active component of , blocks heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway activity. Read More

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http://dx.doi.org/10.1080/15384047.2020.1763147DOI Listing
June 2020
3.072 Impact Factor

Transcriptional information underlying the generation of CSCs and the construction of a nine-mRNA signature to improve prognosis prediction in colorectal cancer.

Cancer Biol Ther 2020 May 26:1-10. Epub 2020 May 26.

Department of General Surgery, Nanfang Hospital, Southern Medical University , Guangzhou, Guangdong, China.

Background: Despite recent progress in screening survival-related genes, there have been few attempts to apply methods based on cancer stem cells (CSCs) for prognosis. We aimed to identify a CSC-based model to predict survival in colorectal cancer (CRC) patients.

Material/methods: Differentially expressed genes between CRC and normal tissues and between CD133- and CD133+ cells were obtained from The Cancer Genome Atlas and Gene Expression Omnibus, and intersections were evaluated. Read More

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http://dx.doi.org/10.1080/15384047.2020.1762419DOI Listing

Identification of potential therapeutic targets in urothelial bladder carcinoma of Chinese population by targeted next-generation sequencing.

Cancer Biol Ther 2020 May 23:1-8. Epub 2020 May 23.

The Key Laboratory of Urinary Tract Tumors and Calculi, Department of Urology Surgery, The First Affiliated Hospital, School of Medicine, Xiamen University , Xiamen, China.

Patients with urothelial carcinoma (UC) of the bladder have a high risk of death in China. However, a lack of comprehensive molecular profiling in Chinese Han population hinders the development of targeted therapies for bladder cancer. In our present study, we collected fresh bladder tumors from low-grade (T1, N0, M0, G1) non-muscle invasive bladder cancer (NMIBC) patients (n = 16) and high-grade (T2-4, N0, M0, Gx) muscle-invasive bladder cancer (MIBC) patients (n = 16) with their paired normal bladder tissues, and subjected the total genomic DNAs to targeted next-generation sequencing (NGS) for 94 cancer-associated genes. Read More

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http://dx.doi.org/10.1080/15384047.2020.1763148DOI Listing
May 2020
3.072 Impact Factor

Exosomal taurine up-regulated 1 promotes angiogenesis and endothelial cell proliferation in cervical cancer.

Authors:
Lei Lei Qinwei Mou

Cancer Biol Ther 2020 May 20:1-9. Epub 2020 May 20.

Department of Gynecology, Baoji Maternal and Children Health Care Hospital, Baoji, Shaanxi, China.

Emerging evidence had highlighted that exosomes could mediate cell-cell communication in human cancerous development via transferring the various molecular cargos, including long non-coding RNA (lncRNA). Taurine up-regulated 1 (TUG1) was previously reported as an oncogenic lncRNA in cervical cancer (CC) via facilitating cell proliferation and other vital biological behaviors. Nevertheless, the presence of TUG1 in exosomes and the functional regulation of exosomal TUG1 in CC are still elusive. Read More

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http://dx.doi.org/10.1080/15384047.2020.1764318DOI Listing

The treatment option of progressive disease in breast cancer during neoadjuvant chemotherapy: a single-center experience.

Cancer Biol Ther 2020 May 18:1-13. Epub 2020 May 18.

Department of Breast Surgery, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.

Patients' responses to breast cancer neoadjuvant chemotherapy (NACT) differ because of heterogeneous tumor characteristics. Reports about NACT progression are sporadic. Here we enrolled 1187 patients who received NACT in our cancer center between January 1, 2007, and December 31, 2016. Read More

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http://dx.doi.org/10.1080/15384047.2020.1756707DOI Listing

ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6.

Authors:
Yang Li An Jiang

Cancer Biol Ther 2020 Jul 18;21(7):647-655. Epub 2020 May 18.

Department of General Surgery in Cadre Ward, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.

Background: Deemed as a member of malignant tumors, hepatocellular carcinoma (HCC) has been characterized as a lethal disease with high morbidity and mortality. It has been widely accepted that long noncoding RNAs (lncRNAs) play a big part in the complicated biologic processes of cancer.

Aim Of The Study: The purpose of the study is to figure out the role and molecular regulation mechanism of ST8SIA6-AS1 in HCC. Read More

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http://dx.doi.org/10.1080/15384047.2020.1743150DOI Listing
July 2020
3.072 Impact Factor

STAT4-mediated down-regulation of miR-3619-5p facilitates stomach adenocarcinoma by modulating TBC1D10B.

Cancer Biol Ther 2020 Jul 13;21(7):656-664. Epub 2020 May 13.

Department of Neurosurgical Intensive Care Unit, Wannan Medical College First Affiliated Hospital, Yijishan Hospital , Wuhu, Anhui Province, China.

Background: MicroRNAs (miRNAs) as the subtype of non-coding RNAs are revealed to be crucial players in cellular activities. It has been reported that miR-3619-5p functions as a tumor inhibitor in several cancers. However, the connection between miR-3619-5p and stomach adenocarcinoma (STAD) remains to be discovered. Read More

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http://dx.doi.org/10.1080/15384047.2020.1754690DOI Listing

Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers.

Cancer Biol Ther 2020 Jul 7;21(7):629-636. Epub 2020 May 7.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA, USA.

Within the microenvironment of solid tumors, stress associated with deficit of nutrients and oxygen as well as tumor-derived factors triggers the phosphorylation-dependent degradation of the IFNAR1 chain of type I interferon (IFN1) receptor and ensuing suppression of the IFN1 pathway. Here we sought to examine the importance of these events in malignant mammary cells. Expression of non-degradable IFNAR1 mutant in mouse mammary adenocarcinoma cells stimulated the IFN1 pathway yet did not affect growth of these cells in vitro or ability to form subcutaneous tumors in the syngeneic mice. Read More

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http://dx.doi.org/10.1080/15384047.2020.1750297DOI Listing

Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer.

Cancer Biol Ther 2020 Jul 4;21(7):637-646. Epub 2020 May 4.

Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University , Harbin, P.R. China.

Ubiquitin-specific proteases (USPs) play important roles in the regulation of many cancer-related biological processes. USPs copy number variation (CNVs) may affect the risk and prognosis of colorectal cancer (CRC). We detected CNVs of USPs genes in 468 matched CRC patients and controls, estimated the associations between the USPs genes CNVs and CRC risk and prognosis and their interactions with environmental factors on CRC risk. Read More

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http://dx.doi.org/10.1080/15384047.2020.1750860DOI Listing

LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2.

Cancer Biol Ther 2020 Jul 26;21(7):615-622. Epub 2020 Apr 26.

Department of Hematology, The First Hospital of Hunan University of Traditional Chinese Medicine , Changsha, Hunan, China.

Acute myeloid leukemia (AML) is a prevalent class of blood disease with a high occurrence rate and relapse rate. The role of dysregulated microRNAs (miRNAs) in AML is emerging. MiR-4260 was identified to be a carcinogenic miRNA in colorectal cancer, but never has it been reported in AML. Read More

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http://dx.doi.org/10.1080/15384047.2020.1740054DOI Listing

LncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma.

Cancer Biol Ther 2020 Jul 24;21(7):604-614. Epub 2020 Apr 24.

Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang, China.

Long noncoding RNAs (lncRNAs) have been reported to play a significant role in the occurrence and progression of tumors. In different tumors, they can either act as an oncogene or tumor suppressor via modulating various target mRNAs. OIP5-AS1 belongs to lncRNA family. Read More

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http://dx.doi.org/10.1080/15384047.2020.1738908DOI Listing

Analysis of long-term outcome of image-guided volumetric modulated arc therapy (VMAT) for primary malignant tumor of the cervical spine.

Cancer Biol Ther 2020 Jul 16;21(7):623-628. Epub 2020 Apr 16.

Department of Radiation Oncology, Peking University Third Hospital , Beijing, China.

Objective: Retrospective analysis of the long-term clinical outcome and acute toxicity of the primary malignant tumor of cervical spine receiving CBCT image-guided VMAT.

Methods: Thirty patients with primary malignant tumor of the cervical spine included in our center, from December 2013 to January 2016, 28 patients were retrospectively studied. The prescription dosage 95% PTV volume dose was 44 Gy, 2. Read More

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http://dx.doi.org/10.1080/15384047.2020.1743149DOI Listing

Expression of Concern: .

Authors:

Cancer Biol Ther 2020 04 7. Epub 2020 Apr 7.

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http://dx.doi.org/10.1080/15384047.2020.1752966DOI Listing

A novel targeted GPC3/CD3 bispecific antibody for the treatment hepatocellular carcinoma.

Cancer Biol Ther 2020 Jul 2;21(7):597-603. Epub 2020 Apr 2.

Department of Bioengineering, Chongqing Academy of Animal Sciences , Chongqing, China.

Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer but has shown limited success to date in the treatment of advanced stage. Recruitment of T cells for cancer treatment is a rapidly growing strategy in immunotherapy such as chimeric antigen receptor T cells and bispecific antibodies. However, unwanted aggregations, structural instability or short serum half-life are major challenges of bispecific antibodies. Read More

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http://dx.doi.org/10.1080/15384047.2020.1743158DOI Listing

Significant response to apatinib monotherapy in heavily pretreated advanced HER2-positive breast cancer: a case report and literature review.

Cancer Biol Ther 2020 Jul 1;21(7):590-596. Epub 2020 Apr 1.

Department of Medical Oncology, The First Hospital of China Medical University , Shenyang, China.

Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug resistance. Novel treatment options are urgently needed to overcome resistance to HER2-targeted therapy. The VEGF/VEGFR (Vascular endothelial growth factor and its receptors) pathway is essential in tumor angiogenesis, which may be a promising target in HER2-positive breast cancer providing a rationale for the use of tyrosine kinase inhibitors (TKIs) targeting VEGFR. Read More

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http://dx.doi.org/10.1080/15384047.2020.1743159DOI Listing

Heat shock proteins as biomarkers of lung cancer.

Cancer Biol Ther 2020 Jun 31;21(6):477-485. Epub 2020 Mar 31.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance. In recent years, heat shock proteins are gaining much importance in the field of cancer research owing to their potential to be key determinants of cell survival and apoptosis. Read More

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http://dx.doi.org/10.1080/15384047.2020.1736482DOI Listing

Rules for scientific progress while living with the COVID-19 Pandemic: from 'benchside' to 'fireside.'

Authors:

Cancer Biol Ther 2020 07 30;21(7):581-582. Epub 2020 Mar 30.

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http://dx.doi.org/10.1080/15384047.2020.1747775DOI Listing

Cytokines secreted by stromal cells in TNBC microenvironment as potential targets for cancer therapy.

Cancer Biol Ther 2020 Jun 26;21(6):560-569. Epub 2020 Mar 26.

Department of Pharmaceutical Science, Albany College of Pharmacy and Health Science, Albany, NY, USA.

In triple-negative breast cancer (TNBC), the lack of therapeutic markers and effective targeted therapies result in an incurable metastatic disease associated with a poor prognosis. Crosstalks within the tumor microenvironment (TME), including those between cancer and stromal cells, affect the tumor heterogeneity, growth, and metastasis. Previously, we have demonstrated that IL-6, IL-8, and CCL5 play a significant role in TNBC growth and metastasis. Read More

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http://dx.doi.org/10.1080/15384047.2020.1739484DOI Listing
June 2020
3.072 Impact Factor

Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review.

Cancer Biol Ther 2020 Jul 25;21(7):583-589. Epub 2020 Mar 25.

Department of Neurosurgery, Shandong Cancer Hospital Affiliated to Shandong University; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan, China.

Up to now, no proven effective medical therapy for surgery and radiation-refractory anaplastic meningioma (AM) exists. Patients with vascular endothelial growth factor receptor 2 (VEGFR-2) positive meningiomas showed significantly shorter progression-free survival. Apatinib is a small-molecule antiangiogenic agent that selectively inhibits VEGFR-2. Read More

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http://dx.doi.org/10.1080/15384047.2020.1740053DOI Listing

Patient-derived cancer modeling for precision medicine in colorectal cancer: beyond the cancer cell line.

Cancer Biol Ther 2020 Jun 25;21(6):495-502. Epub 2020 Mar 25.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Since effective immunotherapeutic agents such as immune checkpoint blockade to treat cancer have emerged, the need for reliable preclinical cancer models that can evaluate and discover such drugs became stronger than ever before. The traditional preclinical cancer model using a cancer cell line has several limitations to recapitulate intra-tumor heterogeneity and tumor activity including interactions between tumor-microenvironment. In this review, we will go over various preclinical cancer models recently discovered including patient-derived xenografts, humanized mice, organoids, organotypic-tumor spheroids, and organ-on-a-chip models. Read More

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http://dx.doi.org/10.1080/15384047.2020.1738907DOI Listing

Isolated pineal gland metastasis of acute lymphocytic leukemia: case report.

Cancer Biol Ther 2020 Jun 25;21(6):503-505. Epub 2020 Mar 25.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Metastasis in the pineal region is a rare condition. To best of our knowledge, there is no case report of isolated pineal metastasis secondary to acute lymphocytic leukemia (ALL). The aim of this study is to show the pineal gland involvement of ALL in a case for the first time in the literature. Read More

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http://dx.doi.org/10.1080/15384047.2020.1735605DOI Listing

Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression.

Cancer Biol Ther 2020 Jun 25;21(6):570-580. Epub 2020 Mar 25.

Department of Urology, The First Affiliated Hospital of Xinjiang Medical University, China.

: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated an unprecedented therapeutic efficacy in hematological malignancies; however, its effectiveness in solid tumors remains elusive. In order to enable CAR-T cells more effective to solid tumors, a inverted chimeric cytokine receptor (ICR) was designed, which is consists of the TGF-β extracellular domain, IL-7 receptor intracellular domain, and co-expression on CAR-T cells.: We selected prostate specific membrane antigen (PSMA) as a target for CAR-T cells, constructed corresponding effector cells, and verified the anti-tumor activity of this enhanced PSMA-CAR-T cell by a series of repeated target cell stimulation experiments in vitro and the anti-tumor capabilities by using mice xenograft model in vivo. Read More

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http://dx.doi.org/10.1080/15384047.2020.1739952DOI Listing

A novel non-agonist c-Met antibody drug conjugate with superior potency over a c-Met tyrosine kinase inhibitor in c-Met amplified and non-amplified cancers.

Cancer Biol Ther 2020 Jun 19;21(6):549-559. Epub 2020 Mar 19.

Research Department, Tanabe Research Laboratories U.S.A., Inc, San Diego, CA, USA.

c-Met is a well-characterized oncogene that is associated with poor prognosis in many solid tumor types. While responses to c-Met inhibitors have been observed in clinical trials, activity appears to be limited to those with MET gene amplifications or mutations. We developed a c-Met targeted antibody-drug conjugate (ADC) with preclinical activity in the absence of MET gene amplification or mutation, and activity even in the context of moderate protein expression. Read More

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http://dx.doi.org/10.1080/15384047.2020.1737490DOI Listing

The antilymphatic metastatic effect of hyaluronic acid in a mouse model of oral squamous cell carcinoma.

Cancer Biol Ther 2020 Jun 18;21(6):541-548. Epub 2020 Mar 18.

Division of Oral Pathology, Beijing Institute of Dental Research, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing, China.

: Lymphatic metastasis is the main cause of low patient survival in cases of oral squamous cell carcinoma (OSCC). Several animal models have been established to uncover the mechanism that regulates lymph node metastasis of OSCC cells. Unfortunately, these models often take a long time to establish. Read More

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http://dx.doi.org/10.1080/15384047.2020.1736737DOI Listing
June 2020
3.072 Impact Factor

The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility.

Cancer Biol Ther 2020 Jun 16;21(6):533-540. Epub 2020 Mar 16.

Department of Biochemistry, University of Crete Medical School, Voutes, Greece.

Recent studies revealed that the histone demethylase KDM2B regulates the epithelial markers E-Cadherin and ZO-1, the RhoA/B/C-small-GTPases and actin cytoskeleton organization, in DU-145 prostate- and HCT-116 colon-tumor cells. Here we addressed the role of KDM2B in the activation of Focal Adhesion Kinase (FAK)-signaling and its involvement in regulating tumor cell motility. We used RT-PCR for gene transcriptional analysis, Western blotting for the assessment of protein expression and activity and wound-healing assay for the study of cell migration. Read More

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http://dx.doi.org/10.1080/15384047.2020.1736481DOI Listing

Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome.

Cancer Biol Ther 2020 Jun 15;21(6):486-494. Epub 2020 Mar 15.

Department of Microbial Genetics, Institute of Microbiology, Biotechnology, and Immunology, Faculty of Biology, University of Łódź, Łódź, Poland.

Many types of cancers, including endometrial cancer, were found to have cyclooxygenase-2 (COX-2) overexpression. Because this enzyme belongs to the group of pro-inflammatory enzymes, so-called NSAIDs (non-steroidal anti-inflammatory drugs) directly inhibit its activity. An increasing number of reports on COX-2 involvement in cancer, as well as on the role of microbiota in abnormal metabolism and signaling of cells, forces the development of new NSAID types. Read More

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http://dx.doi.org/10.1080/15384047.2020.1736483DOI Listing

Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer.

Cancer Biol Ther 2020 Jun 13;21(6):506-521. Epub 2020 Mar 13.

Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA.

Triple-negative breast cancer (TNBC) displays an aggressive clinical course, heightened metastatic potential, and is linked to poor survival rates. Through its lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), this subtype remains unresponsive to traditional targeted therapies. Undesirable and sometimes life-threatening side effects associated with current chemotherapeutic agents warrant the development of more targeted treatment options. Read More

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http://dx.doi.org/10.1080/15384047.2020.1726718DOI Listing
June 2020
3.072 Impact Factor

MiR-324-5p/PTPRD/CEBPD axis promotes papillary thyroid carcinoma progression via microenvironment alteration.

Cancer Biol Ther 2020 Jun 10;21(6):522-532. Epub 2020 Mar 10.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

MiR-324-5p is overexpressed in papillary thyroid carcinoma (PTC) with lymph node metastasis and promotes malignant phenotypes of KTC-1 cell line. However, the detailed regulatory mechanism remains unknown. Tumor microenvironment plays a key role in tumor progression. Read More

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http://dx.doi.org/10.1080/15384047.2020.1736465DOI Listing

Overall tumor genomic instability: an important predictor of recurrence-free survival in patients with localized clear cell renal cell carcinoma.

Cancer Biol Ther 2020 May 1;21(5):424-431. Epub 2020 Mar 1.

Genomics Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.

Measurement of a tumor's overall genomic instability has gathered recent interest over the identification of specific genomic imbalances, as it may provide a more robust measure of tumor aggressiveness. Here we demonstrate the association of tumor genomic instability in the prediction of disease recurrence in patients with clinically localized clear cell renal cell carcinoma (ccRCC). Genomic copy number analysis was performed using SNP-based microarrays on tumors from 103 ccRCC patients. Read More

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http://dx.doi.org/10.1080/15384047.2020.1721251DOI Listing

Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases.

Cancer Biol Ther 2020 May 26;21(5):432-440. Epub 2020 Feb 26.

Department of Tumor Biology, Oslo University Hospital, Oslo, Norway.

Patients with colorectal liver metastases (CLM) commonly receive neoadjuvant chemotherapy (NACT) prior to surgical resection. NACT may induce immunogenic cell death with subsequent recruitment of T-cells to the tumor microenvironment, which could be exploited by immune checkpoint inhibition (ICI). In theory, this could expand the use of ICI to obtain responses also in microsatellite stable colorectal cancer, but evidence to suggest optimal treatment schedules are lacking. Read More

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http://dx.doi.org/10.1080/15384047.2020.1721252DOI Listing
May 2020
3.072 Impact Factor

Correction.

Authors:

Cancer Biol Ther 2020 May 24;21(5):476. Epub 2020 Feb 24.

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http://dx.doi.org/10.1080/15384047.2020.1733804DOI Listing

Combined targeting of EGFR and HER2 against prostate cancer stem cells.

Cancer Biol Ther 2020 May 23;21(5):463-475. Epub 2020 Feb 23.

Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.

Progression of prostate cancer has been associated with EGFR and HER2 activation and to tumor-initiating cells contribution toward chemotherapy resistance. We investigated the efficacy of a dual intervention against EGFR and HER2 to deplete the tumor-initiating cells, optimize the chemotherapy management and prevent the progression of castration-resistant prostate cancer (CRPC) cells. Using DU145, PC3, and 22Rv1 CRPC cell lines, biochemical analysis revealed activation of EGFR, HER2, MAPK, and STAT3 in DU145 and 22Rv1, and AKT and SRC in DU145 and PC-3. Read More

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http://dx.doi.org/10.1080/15384047.2020.1727702DOI Listing

Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1.

Cancer Biol Ther 2020 May 23;21(5):452-462. Epub 2020 Feb 23.

Department of Urology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China.

Drug resistance limits the efficacy of chemotherapy in human cancers. Previous studies reported that long noncoding RNA colon cancer-associated transcript 1 (CCAT1) regulated progression of prostate cancer (PCa). However, the potential role of CCAT1 in the sensitivity of paclitaxel (PTX) in PCa and its mechanism remain largely unknown. Read More

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http://dx.doi.org/10.1080/15384047.2020.1727700DOI Listing

Harnessing the vulnerabilities of p53 mutants in lung cancer - Focusing on the proteasome: a new trick for an old foe?

Cancer Biol Ther 2020 Apr 10;21(4):293-302. Epub 2020 Feb 10.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Gain-of-function (GOF) p53 mutations occur commonly in human cancer and lead to both loss of p53 tumor suppressor function and acquisition of aggressive cancer phenotypes. The oncogenicity of GOF mutant p53 is highly related to its abnormal protein stability relative to wild type p53, and overall stoichiometric excess. We provide an overview of the mechanisms of dysfunction and abnormal stability of GOF p53 specifically in lung cancer, the leading cause of cancer-related mortality, where, depending on histologic subtype, 33-90% of tumors exhibit GOF p53 mutations. Read More

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http://dx.doi.org/10.1080/15384047.2019.1702403DOI Listing

Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma.

Cancer Biol Ther 2020 May 9;21(5):400-411. Epub 2020 Feb 9.

Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.

B Cell-Specific Moloney Murine Leukemia Virus Integration Site 1 (Bmi-1, Bmi1), an epigenetic protein, is necessary for normal stem cell self-renewal in adult animals and for cancer stem cell (CSC) functions in adult animals. To elucidate the functions of Bmi-1 in the oral cavity we created a transgenic mouse line (KrTBmi-1) that expresses ectopic, Flag-tagged Bmi-1 in tongue basal epithelial stem cells only upon doxycycline (DOX) treatment. Genome wide transcriptomics and Ingenuity Pathway Analysis identified several pathways altered by exogenous Bmi-1 expression in the normal tongue epithelium, including EIF2 signaling ( value = 1. Read More

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http://dx.doi.org/10.1080/15384047.2020.1720485DOI Listing

APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis.

Cancer Biol Ther 2020 May 9;21(5):441-451. Epub 2020 Feb 9.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.

Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the crypt-surface axis opposing tumorigenesis. Here, we reveal that expression of the guanylin hormone, but not the GUCY2C receptor, is lost at the earliest stages of transformation in APC-dependent tumors in humans and mice. Read More

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http://dx.doi.org/10.1080/15384047.2020.1721262DOI Listing

The stress-activated protein kinase pathway and the expression of stanniocalcin-1 are regulated by miR-146b-5p in papillary thyroid carcinogenesis.

Cancer Biol Ther 2020 May 9;21(5):412-423. Epub 2020 Feb 9.

Pathology Department, Kuwait University, Kuwait City, Kuwait.

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. Deciphering the pathophysiological mechanisms that contribute to PTC development is essential to the discovery of optimal diagnostic and therapeutic approaches. MiR-146b-5p has been identified as a cancer-associated microRNA highly up-regulated in PTC. Read More

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http://dx.doi.org/10.1080/15384047.2020.1721250DOI Listing

John Mendelsohn's journey in cancer biology and therapy.

Authors:
Rakesh Kumar

Cancer Biol Ther 2020 May 23;21(5):389-390. Epub 2020 Jan 23.

Cancer Biology Program, Rajiv Gandhi Centre for Biotechnology, Trivandrum, India.

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http://dx.doi.org/10.1080/15384047.2020.1712829DOI Listing
May 2020
3.072 Impact Factor

Identification of a new cryptic PML-RARα fusion gene without t(15;17) and biallelic CEBPA mutation in a case of acute promyelocytic leukemia: a case detected only by RT-PCR but not cytogenetics and FISH.

Cancer Biol Ther 2020 Apr 20;21(4):309-314. Epub 2020 Jan 20.

Department of Hematology, the First Affiliated Hospital of Nanchang University, Nanchang, China.

Acute promyelocytic leukemia (APL) is characterized by the presence of promyelocytic leukemia-retinoic acid receptor α (PML-RARα) fusion gene, which is formed following the specific chromosomal translocation t(15;17)(q22;q21). However, cases with PML-RARα generated by occult t(15;17) which are negative by both cytogenetics and fluorescence in situ hybridization (FISH), are difficult to diagnose, leading to impaired treatment effectiveness. In the present study, we reported a case of a 66-year-old male patient, and bone marrow morphology, flow cytometry and cytogenetics did not support the diagnosis of APL. Read More

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http://dx.doi.org/10.1080/15384047.2019.1702398DOI Listing

Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients.

Cancer Biol Ther 2020 May 20;21(5):391-399. Epub 2020 Jan 20.

Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Istituto Gaslini, Genova, Italy.

Patients with high-risk neuroblastoma (HR-NB) often initially respond to therapy, but afterward they become resistant and disease recurred. Unfortunately, it does not exist one or more specific chromosome defects associated with relapse or refractory NB. Recently, genomic evidence from primary tumors indicated that the distal region of chromosome 6q is loss in HR-NB patients with fatal outcome. Read More

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http://dx.doi.org/10.1080/15384047.2019.1704122DOI Listing

PRKCZ-AS1 promotes the tumorigenesis of lung adenocarcinoma via sponging miR-766-5p to modulate MAPK1.

Cancer Biol Ther 2020 Apr 15;21(4):364-371. Epub 2020 Jan 15.

Department of Infectious Diseases, Shulan (Hangzhou) Hospital, Hangzhou, Zhejiang Province, China.

Lung adenocarcinoma (LUAD) is the most prevalent histological subclass of non-small cell lung cancer. Long non-coding RNAs (lncRNAs) have been recognized as the crucial regulatory factors in tumor development and progression. Nevertheless, limited research has been carried on the function of PRKCZ-AS1 in LUAD. Read More

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http://dx.doi.org/10.1080/15384047.2019.1702402DOI Listing

Doxorubicin modulated clock genes and cytokines in macrophages extracted from tumor-bearing mice.

Cancer Biol Ther 2020 Apr 13;21(4):344-353. Epub 2020 Jan 13.

Institute of BiomedicalSciences, University of São Paulo, São Paulo, Brazil.

Circadian rhythm is essential for cellular regulation of physiological, metabolic, and immune functions. Perturbations of circadian rhythms have been correlated with increased susceptibility to cancer and poor prognosis in the cancer treatment. Our aim is to investigate the role of doxorubicin (DOX) treatment on clock genes expression and inflammation in intraperitoneal macrophages and the antitumoral response. Read More

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http://dx.doi.org/10.1080/15384047.2019.1702400DOI Listing

Ibrutinib resistance in a patient with transformed diffuse large B-cell lymphoma from primary pulmonary mucosa-associated lymphoid tissue lymphoma.

Cancer Biol Ther 2020 Apr 13;21(4):303-308. Epub 2020 Jan 13.

Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma is rare among lung neoplasia cases, representing only 0.5%-1% of newly diagnosed primary lung lymphoma. MALT lymphoma with relapsed refractory and malignant transformation is highly heterogeneous and consensus therapy remains undetermined. Read More

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http://dx.doi.org/10.1080/15384047.2019.1700743DOI Listing
April 2020
3.072 Impact Factor