4,118,273 results match your criteria Cancer & metabolism[Journal]


Jak2 mutation expands the thrombophilic panel in children.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department of Medical Science, Pediatric Section, University of Ferrara, Italy.

Cerebral sinus venous thrombosis (CSVT) is an important cause of vascular accidents in children. The diagnosis of the underlying disease allows appropriate and timely management of the risk factors and guide therapy, but the aetiology remains unknown in 20-25% of the cases. We present the first case of a child presenting CSVT caused by the JAK2 V617F mutation, occurring without the haematological abnormalities diagnostic for myeloproliferative neoplasms. Read More

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http://dx.doi.org/10.1111/jth.14999DOI Listing

Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy.

Cancer Commun (Lond) 2020 Jul 12. Epub 2020 Jul 12.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.

Single-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq sensitivity, accuracy, and efficiency have improved due to innovations including more sensitive, automated, and cost-effective single-cell isolation methods with higher throughput as well as ongoing technological development of scRNA-seq protocols. Among the variety of current approaches with distinct features, researchers can choose the most suitable method to carry out their research. Read More

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http://dx.doi.org/10.1002/cac2.12078DOI Listing

Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID-19 pandemic.

Colorectal Dis 2020 Jul 12. Epub 2020 Jul 12.

St Mark's Hospital, Harrow, London, United Kingdom.

Introduction: This report summarises the early experience of implementing elective colorectal cancer surgery during the COVID-19 pandemic METHODS: A pathway to minimize the risk of including COVID-19 positive patients for elective surgery was established. Prioritization and additional safety measures were introduced into clinical practice. Minimal-invasive surgery (MIS) was used where appropriate. Read More

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http://dx.doi.org/10.1111/codi.15247DOI Listing

Breast density, MR imaging biomarkers, and breast cancer risk.

Breast J 2020 Jul 11. Epub 2020 Jul 11.

Diagnostic Imaging Division, Department of Breast Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mammographic breast density and various breast MRI features are imaging biomarkers that can predict a woman's future risk of breast cancer. While mammographic density (MD) has been established as an independent risk factor for the development of breast cancer, MD assessment methods need to be accurate and reproducible for widespread clinical use in stratifying patients based on their risk. In addition, a number of breast MRI biomarkers using contrast-enhanced and noncontrast-enhanced techniques are also being investigated as risk predictors. Read More

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http://dx.doi.org/10.1111/tbj.13965DOI Listing

Quantification of citrullinated histones: development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

EpiCypher Inc, Durham, North Carolina, USA.

Background: Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered by lack of standardized assays.

Objectives: We aimed to develop an assay to reliably quantify nucleosomal H3Cit in human plasma. Read More

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http://dx.doi.org/10.1111/jth.15003DOI Listing

Cancer-associated mutations in normal human endometrium: Surprise or expected?

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Department of Obstetrics and Gynecology, Shimane University, Faculty of Medicine, 89-1, Enya-Cho, Izumo, Shimane, 693-8501, Japan.

The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor cells, for which molecular markers have not been fully identified. Although clonality analysis using X chromosome inactivation patterns has shown that normal human endometrial glands are composed of a monoclonal cell population, whether clonal expansion is derived from stem/progenitor cells remains unclear. Read More

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http://dx.doi.org/10.1111/cas.14571DOI Listing

Impact of Covid19 on a tertiary care pediatric oncology and stem cell transplant unit in Riyadh, Saudi Arabia.

Pediatr Blood Cancer 2020 Jul 12:e28560. Epub 2020 Jul 12.

Department of Pediatric Hematology & Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1002/pbc.28560DOI Listing

Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

FEBS Open Bio 2020 Jul 12. Epub 2020 Jul 12.

Center of Clinical Laboratory, First medical center of Chinese, PLA General Hospital, Beijin, 100853, China.

The identification of non-invasive biomarkers for detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long noncoding RNAs (lncRNAs) have been reported to be possible biomarkers for diagnosis and prognosis of cancer. Here, we examined the suitability of the lncRNA LINC00887 as a potential biomarker for RCC, as its expression has been shown to be elevated in RCC tissue versus normal tissue in the Gene Expression Profiling Interactive Analysis (GEPIA) database. Read More

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http://dx.doi.org/10.1002/2211-5463.12930DOI Listing

Use of Bisphosphonates and Other Bone Supportive Agents in the Management of Prostate Cancer - A UK Perspective.

Int J Clin Pract 2020 Jul 12:e13611. Epub 2020 Jul 12.

Queen's University Belfast, The Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK.

Aim: To explore the practice and views of uro-oncologists in the UK regarding their use of bone supportive agents in patients with prostate cancer.

Methods: An expert-devised online questionnaire was completed by members of the British Uro-oncology Group (BUG).

Results: Of 160 uro-oncologists invited, 81 completed the questionnaire. Read More

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http://dx.doi.org/10.1111/ijcp.13611DOI Listing

Complications After Open and Robotic-Assisted Radical Prostatectomy and Association with Post-Operative Opioid Use: An Analysis of Data from the PREVENTER Trial.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Objective: To evaluate perioperative complications for open and robotic-assisted RP for patients enrolled in the PREVENTER trial to determine predictors and impact on opioid consumption.

Patients And Methods: A prospective cohort of 500 patients undergoing open and robotic-assisted RP were followed to determine rates of complications and opioid use. Complications were classified 30 days post-RP using the Clavien-Dindo system. Read More

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http://dx.doi.org/10.1111/bju.15172DOI Listing

Risk scores for occult cancer in patients with unprovoked venous thromboembolism: results from an individual patient data meta-analysis.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

Background: The RIETE and SOME risk scores aim to identify patients with acute unprovoked venous thromboembolism (VTE) at high risk of occult cancer, but their predictive performance is unclear.

Methods: The scores were evaluated in an individual-patient data meta-analysis. Studies were eligible if enrolling consecutive adults with unprovoked VTE who underwent protocol-mandated screening for cancer. Read More

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http://dx.doi.org/10.1111/jth.15001DOI Listing

Association between weight change during initial chemotherapy and clinical outcome in dogs with multicentric lymphoma.

Vet Comp Oncol 2020 Jul 12. Epub 2020 Jul 12.

Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC.

The majority of the known prognostic factors in dogs with lymphoma have been evaluated before treatment commences or at the time of diagnosis. Prognostic factors evaluated during the initial phase of treatment are less described but may provide important clinical information. In this retrospective study, eighty-two canine lymphoma patients were categorized according to the weight change between diagnosis and after 5 weeks of chemotherapy. Read More

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http://dx.doi.org/10.1111/vco.12637DOI Listing

Primary melanotic tumors of the nervous system: a consecutive case series.

Eur J Neurol 2020 Jul 12. Epub 2020 Jul 12.

Department of Neurology, Yale School of Medicine, New Haven, CT, United States.

Background: Primary melanotic tumors of the nervous system (PMTNS) are thought to be an exceedingly rare group of tumors not captured by tumor registries. We aimed to determine relative incidence, clinical presentation, diagnostic findings, patient management, and outcome.

Methods: We retrospectively searched the database of the Section of Neuro-Oncology, Yale Cancer Center for patients with primary or metastatic melanotic lesions of the nervous system. Read More

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http://dx.doi.org/10.1111/ene.14437DOI Listing

Photodynamic therapy in Dermatology: beyond current indications.

Dermatol Ther 2020 Jul 11. Epub 2020 Jul 11.

Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisboa, Portugal.

Photodynamic therapy (PDT) has long been used in Dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. Read More

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http://dx.doi.org/10.1111/dth.13997DOI Listing

PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence.

Objectives: To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer. Read More

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http://dx.doi.org/10.1111/1471-0528.16411DOI Listing

Effect of Low Energy Shock Wave Therapy on Intravesical Epirubicin Delivery in a Rat Model of Bladder Cancer.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Department of Urology, Urology and Nephrology Center, Mansoura University, Egypt.

Objectives: To study the efficacy of low energy shock wave (LESW) on enhancing intravesical epirubicin (EPI) delivery in a rat model of bladder cancer (BC).

Materials And Methods: 100 female Fischer rats were randomly allocated into five groups; Control, BC, LESW, EPI and EPI plus LESW groups. After BC induction by N-butyl-N-(4-hydroxybutyl)nitrosamine, EPI (0. Read More

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http://dx.doi.org/10.1111/bju.15173DOI Listing

Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Infectious Diseases Clinic, Linyi People's Hospital, Linyi, P.R. China.

Long non-coding RNAs (lncRNAs) have been highlighted as prominent genetic modulators involved in multiple important biological processes of cancer cells, especially in esophageal cancer (EC). We tried to elucidate the potential role of LINC00337 in the progression of EC. Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR-145 exhibited a low expression in EC. Read More

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http://dx.doi.org/10.1096/fj.202000470DOI Listing

Lessening COVID-19 healthcare burden in dental practice via rapid serological tests.

Oral Dis 2020 Jul 12. Epub 2020 Jul 12.

University College London (UCL), Eastman Dental Institute, NIHR University College London Hospitals, Biomedical Research Centre, London, United Kingdom.

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http://dx.doi.org/10.1111/odi.13543DOI Listing

Relapse-Related Molecular Signature in early stage Lung Adenocarcinomas based on BER, STING pathway and TILs.

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University(Army Medical University), Chongqing, 400042, China.

Approximately 30% of patients with early stage NSCLC relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I-LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor-infiltrating lymphocytes (TILs) to explore the relationship between protein expression and prognosis. Read More

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http://dx.doi.org/10.1111/cas.14570DOI Listing

LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on γ-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC cell monolayers in vitro and mice in vivo. Mice were subjected to either total body irradiation (TBI) or partial body irradiation (PBI-BM5). Read More

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http://dx.doi.org/10.1096/fj.202000544RDOI Listing

The effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation.

Perspect Psychiatr Care 2020 Jul 11. Epub 2020 Jul 11.

Department of Family Medicine, Medical Faculty, Istanbul Medipol University, Istanbul, Turkey.

Purpose: Music therapy has been used for relaxation in traditional medicine. This study explored the effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation (HSCT).

Design And Methods: Thirty patients who were hospitalized for bone marrow transplantation were included. Read More

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http://dx.doi.org/10.1111/ppc.12578DOI Listing

Erlotinib for Non-Small Cell Lung Cancer with Leptomeningeal Metastases: A Phase II Study (LOGIK1101).

Oncologist 2020 Jul 12. Epub 2020 Jul 12.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Lessons Learned: This phase II trial evaluated the efficacy of erlotinib for patients with non-small cell lung cancer with leptomeningeal metastasis. The 17 cerebrospinal fluid specimens that were available for epidermal growth factor receptor mutation analysis were all negative for the resistance-conferring T790M mutation. The cytological objective clearance rate was 30. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0640DOI Listing

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.

Protein Sci 2020 Jul 12. Epub 2020 Jul 12.

Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA.

The COVID-2019 pandemic is the most severe acute public health threat of the twenty-first century. To properly address this crisis with both robust testing and novel treatments, we require a deep understanding of the life cycle of the causative agent, the SARS-CoV-2 coronavirus. Here, we examine the architecture and self-assembly properties of the SARS-CoV-2 nucleocapsid protein, which packages viral RNA into new virions. Read More

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http://dx.doi.org/10.1002/pro.3909DOI Listing

Dermatoscopic features of thin (≤ 2mm Breslow thickness) versus thick (> 2mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumors: a multicentric collaborative study by the International Dermoscopy Society.

J Eur Acad Dermatol Venereol 2020 Jul 12. Epub 2020 Jul 12.

1st Department of Dermatology-Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

Background: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria, and escapes clinical detection until it progresses to a thicker and more advanced tumor.

Objective: To investigate the dermatoscopic morphology of thin (≤2mm Breslow thickness) versus thick (>2mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumors.

Methods: Retrospective, morphological case-control study, conducted on behalf of the International Dermoscopy Society. Read More

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http://dx.doi.org/10.1111/jdv.16815DOI Listing

Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. Read More

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http://dx.doi.org/10.1002/jcp.29926DOI Listing

Intraepithelial Tumor Infiltrating Lymphocytes are Associated with Absence of Tumor Budding and Immature/Myxoid Desmoplastic Reaction, and with Better Recurrence-Free Survival in Stage I-III Colorectal Cancer.

Histopathology 2020 Jul 12. Epub 2020 Jul 12.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States.

Aims: Tumor budding (TB), desmoplastic reaction (DR), and intraepithelial tumor infiltrating lymphocytes (iTILs) are recently recognized prognostic factors in colorectal cancer (CRC). In this study, we evaluated their significance and relationship to each other, and their cumulative effect on survival.

Methods And Results: 372 stage I-III CRC cases from 2013-16 were included. Read More

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http://dx.doi.org/10.1111/his.14211DOI Listing

Reduced demand for oral diagnosis during COVID-19: a Brazilian center experience.

Oral Dis 2020 Jul 12. Epub 2020 Jul 12.

Department of Semiology and Clinics, Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.

Brazil represents the new epicenter of novel coronavirus disease 2019 (COVID-19), surpassing the mark of more than one million cases and 50,000 deaths. Despite these terrible numbers, experts estimate that the real size of the epidemic may be up to seven times higher (Hallal et al., 2020). Read More

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http://dx.doi.org/10.1111/odi.13547DOI Listing

Activation of PLAG1 and HMGA2 by gene fusions involving the transcriptional regulator gene NFIB.

Genes Chromosomes Cancer 2020 Jul 12. Epub 2020 Jul 12.

Sahlgrenska Center for Cancer Research, Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

The pleomorphic adenoma (PA), which is the most common salivary gland neoplasm, is a benign tumor characterized by recurrent chromosome rearrangements involving 8q12 and 12q14-15. We have previously shown that the PLAG1 and HMGA2 oncogenes are the targets of these rearrangements. Here, we have identified previously unrecognized subsets of PAs with ins(9;8)/t(8;9) (n=5) and ins(9;12)/t(9;12) (n=8) and breakpoints located in the vicinity of the PLAG1 and HMGA2 loci. Read More

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http://dx.doi.org/10.1002/gcc.22885DOI Listing

Evaluating the Impact of Lymph Node Resampling on Colorectal Cancer Nodal Stage.

Histopathology 2020 Jul 11. Epub 2020 Jul 11.

Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.

Aims: Nodal staging in colorectal cancer (CRC) informs prognosis and guides adjuvant treatment decisions. A standard minimum of 12 lymph nodes is widely used, with additional sampling performed as required. However, there is little data on how lymph node resampling in this context has an impact on nodal stage. Read More

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http://dx.doi.org/10.1111/his.14209DOI Listing

Diffusion tensor imaging reveals changes in non-fat infiltrated muscles in Late Onset Pompe Disease.

Muscle Nerve 2020 Jul 12. Epub 2020 Jul 12.

Department of Neurology, Heimer Institute for muscle Research BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1002/mus.27021DOI Listing

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902.

Transfusion 2020 Jul 12. Epub 2020 Jul 12.

Genentech Inc, San Francisco, California.

Background: Extracorporeal photopheresis (ECP) is an immunomodulatory cellular therapy which has been shown to induce a tolerogenic state in patients with acute and chronic graft-vs-host disease. ECOG-ACRIN explored the activity of ECP as a part of a reduced intensity conditioning regimen in two multicenter trials in patients with MDS (E1902) and lymphomas (E1402). While both studies closed before completing accrual, we report results in 23 patients (17 MDS and 6 lymphoma). Read More

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http://dx.doi.org/10.1111/trf.15798DOI Listing

A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity.

Transfusion 2020 Jul 12. Epub 2020 Jul 12.

American Red Cross, Biomedical Services Headquarters, Washington, DC, USA.

Background: Growth in size and complexity of clinical hematopoietic progenitor cell (HPC) transplant programs necessitates parallel increases in cellular therapy laboratory (CTL) workload. Typically individually developed, HPC product processing is labor and time intensive. Variation in procedure type and numbers across CTLs complicates direct comparisons, and benchmark data are not readily available. Read More

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http://dx.doi.org/10.1111/trf.15899DOI Listing

Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.

Histopathology 2020 Jul 11. Epub 2020 Jul 11.

Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.

Aims: This study was performed to elucidate the clinicopathological characteristics, genetic alterations, and therapeutic targets of primary malignant melanoma of the oesophagus (PMME).

Methods: The clinicopathology and molecular pathology of 13 PMME and 10 skin malignant melanoma (SKMM) cases were analysed via next-generation sequencing (NGS) and immunohistochemistry.

Results: Three-year overall survival rate and the median survival time for PMME patients were 23. Read More

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http://dx.doi.org/10.1111/his.14210DOI Listing

Donor-recipient age interaction and the impact on clinical results after heart transplantation.

Clin Transplant 2020 Jul 12:e14043. Epub 2020 Jul 12.

Cadiothoracic Department, University Hospital of Udine, Udine, Italy.

To evaluate the impact of donor-recipient age matching on clinical outcomes after heart transplantation, a total of 509 patients (January 1990-December 2018, mean follow-up 111±80 months), were stratified into 4 groups (young-R/young-D, young-R/old-D, old-R/young-D, old-R/old-D) according to the recipient (young-R<60, old-R≥60 years) and the donor (young-D<50, old-D≥50 years) age. No difference was found among 30-day mortality (p=0.11) and postoperative complications between groups. Read More

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http://dx.doi.org/10.1111/ctr.14043DOI Listing

Effect of understaging on local recurrence of rectal cancer.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background And Objectives: Magnetic resonance imaging of the pelvis has a limited accuracy to detect positive lymph nodes but does dictate neoadjuvant treatment in rectal cancer. This study aimed to investigate preoperative lymph node understaging and its effects on postoperative local recurrence rate.

Methods: Patients were selected from a retrospective cross-sectional snapshot study. Read More

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http://dx.doi.org/10.1002/jso.26111DOI Listing

Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgical Oncology, Mayo Clinic, Jacksonville, Florida.

Background: Relatively few cutaneous head and neck melanoma (CHNM) patients with were included in the multicenter selective lymphadenectomy trial II (MSLT-II). Our objective was to investigate whether immediate completion lymph node dissection completion of lymph node dissection (CLND) was associated with survival benefit for sentinel lymph node (SLN) positive CHNM using the National Cancer Database.

Methods: SLN positive patients with CHNM from 2012 to 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jso.26119DOI Listing

External validation of a hidden Markov model for gamma-based classification of anatomical changes in lung cancer patients using EPID dosimetry.

Med Phys 2020 Jul 12. Epub 2020 Jul 12.

Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Purpose: To externally validate a hidden Markov model (HMM) for classifying gamma analysis results of in vivo electronic portal imaging device (EPID) measurements into different categories of anatomical change for lung cancer patients. Additionally, the relationship between HMM classification and deviations in dose-volume histogram (DVH) metrics was evaluated.

Methods: The HMM was developed at CHU de Québec (CHUQ), and trained on features extracted from gamma analysis maps of in vivo EPID measurements from 483 fractions (24 patients, treated with 3D-CRT or IMRT), using the EPID measurement of the first treatment fraction as reference. Read More

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http://dx.doi.org/10.1002/mp.14385DOI Listing

Comparison of CBCT-based dose calculation methods in head and neck cancer radiotherapy: from Hounsfield unit to density calibration curve to deep learning.

Med Phys 2020 Jul 12. Epub 2020 Jul 12.

Univ. Rennes, CLCC Eugène Marquis, INSERM, LTSI - UMR 1099, F-35000, Rennes, France.

Purpose: Anatomical variations occur during head and neck (H&N) radiotherapy treatment. kV cone-beam computed tomography (CBCT) images can be used for daily dose monitoring to assess dose variations owing to anatomic changes. Deep learning methods (DLMs) have recently been proposed to generate pseudo-CT (pCT) from CBCT to perform dose calculation. Read More

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http://dx.doi.org/10.1002/mp.14387DOI Listing

CT-based Multi-organ Segmentation using a 3D Self-attention U-Net Network for Pancreatic Radiotherapy.

Med Phys 2020 Jul 12. Epub 2020 Jul 12.

Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.

Purpose: Segmentation of organs-at-risk (OARs) is a weak link in radiotherapeutic treatment planning process because the manual contouring action is labor-intensive and time-consuming. This work aimed to develop a deep learning-based method for rapid and accurate pancreatic multi-organ segmentation that can expedite the treatment planning process.

Methods: We retrospectively investigated one hundred patients with CT simulation scanned and contours delineated. Read More

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http://dx.doi.org/10.1002/mp.14386DOI Listing

Glioma cells survival depends both on fatty acid oxidation and on functional carnitine transport by SLC22A5.

J Neurochem 2020 Jul 12. Epub 2020 Jul 12.

Laboratory of Transport through Biomembranes, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.

Gliomas are the most common primary malignant brain tumor in adults, but current treatment for glioblastoma multiforme (GBM) is insufficient. Even though glucose is the primary energetic substrate of glioma cells, they are capable of using fatty acids to generate energy. Fatty acid oxidation (FAO) in mitochondria requires L-carnitine for the formation of acylcarnitines by carnitine palmitoylotransferase 1 (CPT1) and further transport of acyl carnitine esters to mitochondrial matrix. Read More

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http://dx.doi.org/10.1111/jnc.15124DOI Listing

Accumulation of amyloid beta in human glioblastomas.

Clin Exp Immunol 2020 Jul 12. Epub 2020 Jul 12.

Physiology department, Medical School, Universidad Central del Caribe, Ave Laurel, Santa Juanita, Bayamon, PR 00956, Puerto Rico.

Many cancer types are intrinsically associated with specific types of amyloidosis, in which amyloidis accumulated locally inside tumors or systemically. Usually, this condition relates to the hyper-production of specific amylogenic proteins. Recently, we found that the accumulation of amyloid beta (Aβ) peptide immunofluorescence is linked to glioma cells in mouse tumors. Read More

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http://dx.doi.org/10.1111/cei.13493DOI Listing

Appendiceal conduit: A novel technique to be applied after radical cystectomy: A case study report.

Urol J 2020 Jun 18. Epub 2020 Jun 18.

Student Research Committee, Babol University of Medical Sciences, Babol, I.R. Iran.

This paper introduces a novel technique, known as appendiceal conduit. It could be used as an alternative for ileal conduit and cutaneous ureterostomy, ultimately applied after radical cystectomy. The six-month follow-up indicated that the patient had appendix-stoma as nipple without any stenosis, nor did he have any hydronephrosis, as confirmed by abdominal sonography. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5513DOI Listing

MiR-92 overexpression suppresses immune cell function in ovarian cancer via LATS2/YAP1/PD-L1 pathway.

Authors:
S Feng H Sun W Zhu

Clin Transl Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu Province, People's Republic of China.

Purpose: Increasing evidence suggested that microRNA plays an important role in ovarian cancer. In this study, the role of miR-92 in ovarian cancer was investigated.

Methods: In this study, miR-92 expression in clinical sample was evaluated, role of miR-92 was investigated in vitro, and underlying mechanism was investigated using Chip, co-IP, and western blot. Read More

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http://dx.doi.org/10.1007/s12094-020-02439-yDOI Listing

A Comprehensive Approach to the Management of Benign and Malignant Ampullary Lesions: Management in Hereditary and Sporadic Settings.

Curr Gastroenterol Rep 2020 Jul 11;22(9):46. Epub 2020 Jul 11.

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

Purpose Of Review: The purpose of this review was to examine the historical roots of endoscopic management of ampullary lesions and explore emerging data on improved techniques, technologies, and outcomes. Of specific interest was answering whether there exists a reasonable body of data to support one resection technique or strategy above others.

Recent Findings: Review of recent literature suggests the continued use of endoscopic ampullectomy is a safe and effective means of curative treatment of ampullary adenomas. Read More

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http://dx.doi.org/10.1007/s11894-020-00784-0DOI Listing

Successful endoscopic mucosal resection for non-ampullary duodenal signet-ring cell carcinoma.

Clin J Gastroenterol 2020 Jul 11. Epub 2020 Jul 11.

Department of Gastroenterology, St. Luke's International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo, 104-8560, Japan.

We present a case of non-ampullary duodenal signet-ring cell carcinoma treated by endoscopic mucosal resection. The patient is a 61-year-old male with a history of coronary artery bypass grafting, hypertension, dyslipidemia, and diabetes mellitus complicated by end-stage renal disease requiring peritoneal dialysis who presented for routine endoscopic screening. A 9 mm protruding mass was found in the second part of the duodenum, proximal to the ampulla of Vater. Read More

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http://dx.doi.org/10.1007/s12328-020-01173-wDOI Listing

In vitro anti-breast cancer studies of LED red light therapy through autophagy.

Breast Cancer 2020 Jul 11. Epub 2020 Jul 11.

School of Biological Sciences, Universiti Sains Malaysia, Minden Heights, 11800 USM, Pulau Pinang, Malaysia.

LED red light has been reported to have many health benefits. The present study was conducted to characterise anti-proliferation properties of four LED red light wavelengths (615, 630, 660 and 730 nm) against non-triple negative (MCF-7) and triple negative (MDA-MB-231) breast cancer-origin cell lines. It has been shown by MTT assay that at 24 h post-exposure time point, only LED red light with wavelength 660 nm possessed anti-proliferative effects against both cell lines with 40% reduction of cell viability. Read More

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http://dx.doi.org/10.1007/s12282-020-01128-6DOI Listing

Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer.

Cancer Chemother Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.

Gemcitabine (GEM), as an anti-metabolic nucleoside analog, has been shown to have anticancer effects in various tumors, but its chemotherapy resistance is still an important factor leading to poor prognosis of cancer patient. A large number of studies in recent years have shown that autophagy plays an important role in the chemotherapy sensitivity of many tumors, including pancreatic, non-small cell lung, and bladder cancer. However, whether GEM causes autophagy in gallbladder cancer (GBC) and whether it is related to chemotherapy resistance is unknown. Read More

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http://dx.doi.org/10.1007/s00280-020-04100-5DOI Listing

Cylindroma, an uncommon presentation on F-DCFPyL PET/CT.

Eur J Nucl Med Mol Imaging 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology & Nuclear Medicine, Amsterdam University Medical Centers (VU University), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00259-020-04943-3DOI Listing

Evaluation of COVID 19 infection in 279 cancer patients treated during a 90-day period in 2020 pandemic.

Authors:
Mozaffar Aznab

Int J Clin Oncol 2020 Jul 11. Epub 2020 Jul 11.

Medical oncologist-Hematologist, Internal Medicine Department, Talaghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The aim of this study was investigation of COVID-19 disease and its outcome in cancer patients who needed treatment, in a 90-day period.

Methods: Cancer patient who required treatment, were evaluated for potential COVID-19 infection in a 90-day period, starting from beginning of this epidemic in Iran, January, to April 19, 2020. For treatment of solid tumor patients, if they did not have symptoms related to COVID-19, just chest X-ray was requested. Read More

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http://dx.doi.org/10.1007/s10147-020-01734-6DOI Listing

Clinical characteristics and predictors of permanent stoma in rectal cancer patients underwent anterior resections: the value of preoperative prognostic nutritional index.

Int J Clin Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Essential Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

Objectives: This study was aimed to investigate the correlation between preoperative prognostic nutritional index (PNI) and permanent stoma (PS) in patients with defunctioning stoma (DS) after anterior resections and, based on it, to reveal the clinical value of PNI on clinical strategies about the selection of stoma location.

Methods: A total of 281 consecutive rectal cancer patients who accepted anterior resection and DS in the National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University from June 2008 to June 2018 were enrolled in this study. Receiver operating characteristic (ROC) curve for PNI was performed to discriminate PS. Read More

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http://dx.doi.org/10.1007/s10147-020-01743-5DOI Listing
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