51,388 results match your criteria Cancer[Journal]


A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors.

Cancer 2018 Jun 22. Epub 2018 Jun 22.

Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama.

Background: The current study assessed the feasibility of a mentored home-based vegetable gardening intervention and examined changes in health-related outcomes among breast cancer survivors (BCS).

Methods: BCS were randomized to either a year-long vegetable gardening intervention to begin immediately or a wait-list control. Master Gardeners mentored participants in planning, planting, and maintaining 3 seasonal gardens over the course of 1 year. Read More

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June 2018
2 Reads

Evaluation of 2 breast cancer risk models in a benign breast disease cohort.

Cancer 2018 Jun 22. Epub 2018 Jun 22.

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Background: More than 1.5 million women per year have a benign breast biopsy resulting in concern about their future breast cancer (BC) risk. This study examined the performance of 2 BC risk models that integrate clinical and histologic findings in this population. Read More

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Racial and ethnic disparities in travel for head and neck cancer treatment and the impact of travel distance on survival.

Cancer 2018 Jun 22. Epub 2018 Jun 22.

Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.

Background: Patients who travel a long distance (≥50 miles) for cancer care have improved outcomes. However, to the authors' knowledge, the prevalence of long travel distances for treatment by patients with head and neck squamous cell carcinoma (HNSCC), and the effect of travel distance on overall survival (OS), remains unknown.

Methods: The authors used the National Cancer Data base from 2004 through 2013 to identify patients with HNSCC undergoing definitive treatment. Read More

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June 2018
1 Read

CSF3R mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia.

Cancer 2018 Jun 22. Epub 2018 Jun 22.

Division of Pathology and Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China.

Background: Mutations in the colony-stimulating factor 3 receptor (CSF3R) gene occur frequently in chronic neutrophilic leukemia and are rare in de novo acute leukemia. The objective of this study was to assess the incidence of CSF3R mutations in acute leukemia and their association with other genetic abnormalities.

Methods: Amplicon-targeted, next-generation sequencing of 58 genes was performed retrospectively on 1152 patients (acute myeloid leukemia [AML], n = 587; acute lymphoid leukemia [ALL], n = 565). Read More

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Tumours trigger systemic disruption.

Nat Rev Cancer 2018 Jun 21. Epub 2018 Jun 21.

Nature Reviews Cancer, .

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Efficacy of a hypnosis-based intervention to improve well-being during cancer: a comparison between prostate and breast cancer patients.

BMC Cancer 2018 Jun 22;18(1):677. Epub 2018 Jun 22.

Algology-Palliative Care Department, University Hospital of Liège, Sensation and Perception Research Group, GIGA Consciousness, University of Liège, Liège, Belgium.

Background: Prostate and breast cancer can have a lot of negative consequences such as fatigue, sleep difficulties and emotional distress, which decrease quality of life. Group interventions showed benefits to emotional distress and fatigue, but most of these studies focus on breast cancer patients. However, it is important to test if an effective intervention for breast cancer patients could also have benefits for prostate cancer patients. Read More

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Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps.

BMC Cancer 2018 Jun 22;18(1):678. Epub 2018 Jun 22.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Background: The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular traps (NETs), whereby activated neutrophils release their intracellular contents containing DNA, histones, tissue factor, high mobility group box 1 (HMGB1) and other components have been implicated in PDA and in cancer-associated thrombosis.

Methods: Utilizing an orthotopic murine PDA model in C57/Bl6 mice and patient correlative samples, we studied the role of NETs in PDA hypercoagulability and targeted this pathway through treatment with the NET inhibitor chloroquine. Read More

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Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines.

BMC Cancer 2018 Jun 22;18(1):675. Epub 2018 Jun 22.

The Hiram C. Polk, Jr MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY, 40292, USA.

Background: More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specific mutation V600E in the BRAF protein. Read More

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Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer.

BMC Cancer 2018 Jun 22;18(1):679. Epub 2018 Jun 22.

Department of Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 105, Haartmaninkatu 4, Terkon tutkijatilat, 3. krs, FIN-00029 HUS, Helsinki, Finland.

Background: Almost all of the extracellular matrix (ECM) components can be degraded by the endoproteinases matrix metalloproteinases (MMPs). Important regulators of MMPs, and thereby of the extracellular environment, are tissue inhibitors of metalloproteinases (TIMPs), and especially TIMP-1. Early tumor development, as well as distant metastasis, may be results of an MMP/TIMP ratio imbalance altering the ECM. Read More

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Droplet digital PCR-based circulating microRNA detection serve as a promising diagnostic method for gastric cancer.

BMC Cancer 2018 Jun 22;18(1):676. Epub 2018 Jun 22.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.

Background: Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) in plasma suggested a promising role as GC biomarkers.

Methods: Based on the quantitative droplet digital PCR (ddPCR), four miRNAs (miR-21, miR-93, miR-106a and miR-106b) related to the presence of GC were identified in plasma from a training cohort of 147 participants and a validation cohort of 28 participants. Read More

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Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer.

BMC Cancer 2018 Jun 20;18(1):672. Epub 2018 Jun 20.

Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity of the disease, the clinical outcomes, prognostic factors and clinical decision on the optimal treatments have not been fully understood.

Methods: In this study, we retrospectively analyzed the clinical data of 124 patients with high-grade salivary gland cancers and performed multivariate survival analyses to evaluate the clinico-pathological factors affecting the treatment outcomes. Read More

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WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.

BMC Cancer 2018 Jun 20;18(1):673. Epub 2018 Jun 20.

Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Background: KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein complex that requires WDR5. WDR5 has been implicated in cancer for its role in the COMPASS complex and its interaction with Myc; however, the role of WDR5 in colon cancer has not yet been elucidated. Read More

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Induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin in Japanese patients with HER2-negative metastatic breast cancer: a multicenter, collaborative, open-label, phase II clinical study for the SBCCSG 35 investigators.

BMC Cancer 2018 Jun 20;18(1):671. Epub 2018 Jun 20.

Department of Pathology, Saitama Cancer Center, 780 Komuro, Ina-machi, Kita-adachi-gun, Saitama, 362-0806, Japan.

Background: To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast cancer (MBC).

Methods: Patients, who had previously undergone a maximum of 2 regimens of chemotherapy, received 3 cycles of induction therapy with paclitaxel (90 mg/m intravenously on days 1, 8, and 15 followed by 1-week drug holiday) and bevacizumab (10 mg/kg intravenously after the completion of paclitaxel administration on days 1 and 15). Patients who had complete response, partial response, or stable disease underwent switch maintenance therapy with eribulin (1. Read More

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HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells.

BMC Cancer 2018 Jun 20;18(1):674. Epub 2018 Jun 20.

Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

Background: Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is known to contribute to metastatic progression, little is known about the mechanism by which heterogeneic hypoxia contributes to cancer progression. Read More

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The intersection of financial toxicity and family building in young adult cancer survivors.

Cancer 2018 Jun 20. Epub 2018 Jun 20.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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Falling short to compete.

Authors:
Paulina Strzyz

Nat Rev Cancer 2018 Jun 19. Epub 2018 Jun 19.

Associate Editor, Nature Reviews Molecular Cell Biology, .

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Which approach is preferred in left hepatocellular carcinoma? Laparoscopic versus open hepatectomy using propensity score matching.

BMC Cancer 2018 Jun 19;18(1):668. Epub 2018 Jun 19.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, Republic of Korea.

Background: Laparoscopic liver resection has been reported as a safe and effective approach for the management of hepatocellular carcinoma (HCC). However, its perioperative and oncological outcomes have not been evaluated in left hepatectomy patients. The aim of the present study is to compare the outcomes of left hepatectomy through laparoscopic and open approaches in left HCC. Read More

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June 2018
1 Read

PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.

BMC Cancer 2018 Jun 19;18(1):669. Epub 2018 Jun 19.

Key laboratory of Molecular Imaging of CAS, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, No. 95 ZhongGuanCun East Road, Beijing, 100190, China.

Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model. Read More

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June 2018
1 Read

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association.

BMC Cancer 2018 Jun 19;18(1):670. Epub 2018 Jun 19.

Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA.

Background: The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signaling by TGF-β cytokines, while the role of TGF-β signaling in the regulation of tumor blood vessels is not fully understood. The current study presents evidence that TAFs enhance the organization of tumor blood capillaries, and TGF-β signaling plays an important role in this response. Read More

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Metabolizing microbes in control.

Authors:
Anna Dart

Nat Rev Cancer 2018 Jun 18. Epub 2018 Jun 18.

Nature Reviews Cancer, .

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Long non-coding RNA RUNXOR accelerates MDSC-mediated immunosuppression in lung cancer.

BMC Cancer 2018 Jun 18;18(1):660. Epub 2018 Jun 18.

Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, 212012, China.

Background: RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA that has been indicated as a key regulator in the development of myeloid cells by targeting runt-related transcription factor 1 (RUNX1). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells consisting of immature granulocytes and monocytes with immunosuppression. However, the impact of lncRNA RUNXOR on the development of MDSCs remains unknown. Read More

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Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway.

BMC Cancer 2018 Jun 18;18(1):661. Epub 2018 Jun 18.

Department of Pathology, The Second Clinical College of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine, 111 Dade Road, Guangzhou, 510120, Guangdong, China.

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related deaths worldwide. Despite new technologies in diagnosis and treatment, the incidence and mortality of HCC continue rising. And its pathogenesis is still unclear. Read More

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Treatment in the STAMPEDE era for castrate resistant prostate cancer in the UK: ongoing challenges and underappreciated clinical problems.

BMC Cancer 2018 Jun 19;18(1):667. Epub 2018 Jun 19.

The Department of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, UK.

Background: This study aimed to explore the opinions of healthcare professionals regarding the management of men with advanced prostate cancer with particular emphasis on treatment timing and sequencing; treatment adverse-effects and exercise a supportive therapy.

Methods: Semi-structured interviews with a purposively selected group of healthcare professionals involved in prostate cancer care within the NHS, conducted over the phone or face to face. A total of 37 healthcare professionals participated in the interviews including urologists, clinical oncologists, medical oncologists, clinical nurse specialists, general practitioners, physiotherapists, exercise specialists, service managers, clinical commissioners and primary care physicians. Read More

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June 2018
2 Reads

Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients.

BMC Cancer 2018 Jun 8;18(1):644. Epub 2018 Jun 8.

Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.

Background: This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment by CalliSpheres® in Chinese patients with hepatocellular carcinoma (HCC) as well as the predicting factors for response.

Methods: 99 patients with HCC were consecutively enrolled in this study. All participants were treated by CalliSpheres® DEB-TACE. Read More

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Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.

BMC Cancer 2018 Jun 18;18(1):664. Epub 2018 Jun 18.

Institute of Biomedicine, University of Eastern Finland, 70211, Kuopio, Finland.

Background: Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface receptor, CD44 and the expression of hyaluronan metabolizing enzymes, in these aggressive tumors. Hyaluronan is the main component of extracellular matrix in the brain. Read More

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Effects of local anesthetics on breast cancer cell viability and migration.

BMC Cancer 2018 Jun 19;18(1):666. Epub 2018 Jun 19.

Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA.

Background: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Read More

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Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients.

BMC Cancer 2018 Jun 18;18(1):662. Epub 2018 Jun 18.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing, 100142, People's Republic of China.

Background: RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explored the association between RECQL expression level and survival in patients with breast cancer. Read More

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Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico.

BMC Cancer 2018 Jun 18;18(1):665. Epub 2018 Jun 18.

Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.

Gallbladder cancer is a rare malignancy of the biliary tract with a poor prognosis, frequently presenting at an advanced stage. While rare in the United States overall, gallbladder cancer has an elevated incidence in geographically distinct locations of the globe including Chile, North India, Korea, Japan and the state of New Mexico in the United States. People with Native American ancestry have a much elevated incidence of gallbladder cancer compared to Hispanic and non-Hispanic white populations of New Mexico. Read More

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MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

BMC Cancer 2018 Jun 18;18(1):663. Epub 2018 Jun 18.

Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Children's Hospital, Heidelberg, Germany.

Background: Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Read More

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June 2018
3 Reads

A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.

BMC Cancer 2018 Jun 15;18(1):658. Epub 2018 Jun 15.

Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.

Background: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC).

Methods: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. Read More

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June 2018
2 Reads

MALBAC-based chromosomal imbalance analysis: a novel technique enabling effective non-invasive diagnosis and monitoring of bladder cancer.

BMC Cancer 2018 Jun 15;18(1):659. Epub 2018 Jun 15.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Road, Guangzhou, China.

Background: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. Read More

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June 2018
1 Read

Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer.

BMC Cancer 2018 Jun 15;18(1):657. Epub 2018 Jun 15.

Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo, 173 0003, Japan.

Background: A previous report showed that a glucagon-like peptide-1 receptor (GLP-1R) agonist (exenatide) induced apoptosis in endometrial cancer cells. However, the pathophysiological role of GLP-1R in endometrial cancer has not been fully elucidated. Here, we investigated the effects of the GLP-1R agonist liraglutide in endometrial cancer cells and examined the association between GLP-1R expression and clinicopathological characteristics in endometrial cancer patients. Read More

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June 2018
1 Read

Is immune checkpoint inhibition part of standard therapy for stage III non-small cell lung cancer?

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Radiation Oncology, The University of Chicago, Illinois.

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Variation in prostate cancer treatment and spending among Medicare shared savings program accountable care organizations.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Division of Oncology, Department of Urology, University of Michigan, Ann Arbor, Michigan.

Background: Accountable care organizations (ACOs) have been shown to reduce prostate cancer treatment among men unlikely to benefit because of competing risks (ie, potential overtreatment). This study assessed whether the level of engagement in ACOs by urologists affected rates of treatment, overtreatment, and spending.

Methods: A 20% sample of national Medicare data was used to identify men diagnosed with prostate cancer between 2012 and 2014. Read More

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June 2018
1 Read

Quality of life in patients with proton-treated pediatric medulloblastoma: Results of a prospective assessment with 5-year follow-up.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

Background: To the authors' knowledge, health-related quality of life (HRQOL) outcomes are not well described in patients with medulloblastoma. The use of proton radiotherapy (RT) may translate into an improved HRQOL. In the current study, the authors report long-term HRQOL in patients with proton-treated pediatric medulloblastoma. Read More

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June 2018
3 Reads

Life stress as a risk factor for sustained anxiety and cortisol dysregulation during the first year of survivorship in ovarian cancer.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.

Background: Patients with ovarian cancer often report elevated anxiety at diagnosis that decreases posttreatment. However, a minority of patients experience sustained anxiety. Few studies have examined risk factors for persistent anxiety or its physiologic sequelae in ovarian cancer. Read More

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June 2018
2 Reads

Iron overload in patients with myelodysplastic syndromes: An updated overview.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Internal Medicine, American University of Beirut, Naef K. Basile Cancer Institute, Beirut, Lebanon.

Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by a broad clinical spectrum related to ineffective hematopoiesis leading to unilineage or multilineage cytopenias, with a high propensity for transformation to acute myeloid leukemia. Iron overload has been recently identified as one of the important conditions complicating the management of these diverse disorders. The accumulation of iron is mainly related to chronic transfusions; however, evidence suggests a possible role for ineffective erythropoiesis and increased intestinal absorption of iron, related to altered hepcidin and growth differentiation factor-15 levels in the development of hemosiderosis in patients with MDS. Read More

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Quality of life as a prognostic indicator of survival: A pooled analysis of individual patient data from Canadian Cancer Trials Group clinical trials.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Quality of Life Department, European Organization for Research and Treatment of Cancer, Brussels, Belgium.

Background: The aims of this study were to externally validate an established association between baseline health-related quality of life (HRQOL) scores and survival and to assess the added prognostic value of HRQOL with respect to demographic and clinical indicators.

Methods: Pooled data were analyzed from 17 randomized controlled trials opened by the Canadian Cancer Trials Group between 1991 and 2004; they included survival and baseline HRQOL data from 3606 patients with 8 different cancer sites. The models included sex, age (≤60 vs >60 years), World Health Organization performance status (0 or 1 vs 2-4), distant metastases (no vs yes), and 15 European Organization for Research and Treatment of Cancer (EORTC) Core Quality-of-Life Questionnaire (QLQ-C30) scales. Read More

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June 2018
3 Reads

Symptoms of posttraumatic stress disorder among hospitalized patients with cancer.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Background: Patients with cancer experience many stressors placing them at risk for posttraumatic stress disorder (PTSD) symptoms, yet little is known about factors associated with PTSD symptoms in this population. This study explored relationships among patients' PTSD symptoms, physical and psychological symptom burden, and risk for hospital readmissions.

Methods: We prospectively enrolled patients with cancer admitted for an unplanned hospitalization from August 2015-April 2017. Read More

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The classification of pediatric and young adult renal cell carcinomas registered on the Children's Oncology Group (COG) protocol AREN03B2 after focused genetic testing.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Pathology and Laboratory Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago,`, Chicago, Illinois.

Background: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). Read More

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Beyond classic risk adjustment: Socioeconomic status and hospital performance in urologic oncology surgery.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Department of Urology, University of Washington, Seattle, Washington.

Background: Safety-net hospitals (SNHs) care for more patients of low socioeconomic status (SES) than non-SNHs and are disproportionately punished under SES-naive Medicare readmission risk-adjustment models. This study was designed to develop a risk-adjustment framework that incorporates SES and to assess the impact on readmission rates.

Methods: California Office of Statewide Health Planning and Development data from 2007 to 2011 were used to identify patients undergoing radical cystectomy (RC) for bladder cancer (n = 3771) or partial nephrectomy (PN; n = 5556) or radical nephrectomy (RN; n = 13,136) for kidney cancer. Read More

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Multicenter, randomized, double-blind phase 2 trial of FOLFIRI with regorafenib or placebo as second-line therapy for metastatic colorectal cancer.

Cancer 2018 Jun 15. Epub 2018 Jun 15.

Indiana University, Indianapolis, Indiana.

Background: Regorafenib, a multikinase inhibitor that inhibits angiogenesis, growth, and proliferation, prolongs survival as monotherapy in patients with refractory colorectal cancer. This international, double-blind, placebo-controlled, multicenter trial assessed the efficacy of regorafenib with folinic acid, fluorouracil, and irinotecan (FOLFIRI) as a second-line treatment for metastatic colorectal cancer.

Methods: Patients with metastatic colorectal cancer who progressed on first-line oxaliplatin and fluoropyrimidine enrolled at 45 sites in the United States and Ireland. Read More

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June 2018
1 Read

Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes.

BMC Cancer 2018 Jun 15;18(1):654. Epub 2018 Jun 15.

Department of Oncology, Oslo University Hospital, Ullevål, N-0424, Oslo, Norway.

Background: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.

Methods: A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Read More

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TOPical Imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia (TOPIC-2 trial): a study protocol for a randomized controlled trial.

BMC Cancer 2018 Jun 15;18(1):655. Epub 2018 Jun 15.

Department of Obstetrics and Gynecology, Erasmus Medical Center Cancer Institute, Post box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. This procedure has potential complications, such as haemorrhage, infection and preterm birth in subsequent pregnancies. Read More

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June 2018
2 Reads

ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.

BMC Cancer 2018 Jun 15;18(1):656. Epub 2018 Jun 15.

Laboratory of Molecular Oncology, Cancer Research Institute, Biomedical Research Center of SAS, Dubravska cesta 9, 845 05, Bratislava, Slovakia.

Background: Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations of cells, one of them, known as cancer stem cells, being attributed many important properties such as enhanced tumorigenicity, proliferation potential and profound multidrug resistance to chemotherapy. Several key stem cells markers were identified in colon cancer. In our study we focused on the aldehyde dehydrogenase type 1 (ALDH1) expression in colon cancer-derived cell lines HT-29/eGFP, HCT-116/eGFP and LS-180/eGFP, and its role in the chemoresistance and tumorigenic potential. Read More

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June 2018
1 Read

Targeting ATR in cancer.

Nat Rev Cancer 2018 Jun 13. Epub 2018 Jun 13.

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic. However, the efficacy of such therapies is often limited by the side effects of these drugs on healthy cells. Read More

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Increasing incidence of central nervous system (CNS) tumors (2000-2012): findings from a population based registry in Gironde (France).

BMC Cancer 2018 Jun 14;18(1):653. Epub 2018 Jun 14.

Equipe EPICENE, Centre INSERM U1219-Bordeaux Population Health Center, Université de Bordeaux, Bordeaux, France.

Background: Although some countries have observed a stabilization in the incidence of CNS, an increasing incidence has been reported from multiple studies. Recent observations point out to the heterogeneity of incidence trends according to histological subtypes, gender and age-groups. Using a high-quality regional CNS tumor registry, this article describes the trends of CNS tumor incidence for main histological subtypes, including benign and malignant tumors, in the French department of Gironde from 2000 to 2012. Read More

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June 2018
7 Reads