52,995 results match your criteria Cancer[Journal]


National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer.

Cancer 2019 Apr 24. Epub 2019 Apr 24.

Clinical Radiation Oncology Branch, Radiation Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Colorectal cancer (CRC) represents a major public health problem as the second leading cause of cancer-related mortality in the United States. Of an estimated 140,000 newly diagnosed CRC cases in 2018, roughly one-third of these patients will have a primary tumor located in the distal large bowel or rectum. The current standard-of-care approach includes curative-intent surgery, often after preoperative (neoadjuvant) radiotherapy (RT), to increase rates of tumor down-staging, clinical and pathologic response, as well as improving surgical resection quality. Read More

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http://dx.doi.org/10.1002/cncr.32150DOI Listing

Factors associated with low adherence to cervical cancer follow-up retest among HPV+/ cytology negative women: a study in programmatic context in a low-income population in Argentina.

BMC Cancer 2019 Apr 23;19(1):367. Epub 2019 Apr 23.

Centro de Estudios de Estado y Sociedad/Consejo Nacional de Investigaciones Científicas y Técnicas, Sánchez de Bustamante 27, Buenos Aires, Argentina.

Background: Cervical Cancer is still a major public health challenge in low and middle-income countries. HPV testing has been an innovative approach, which was introduced in Argentina for women aged 30+ through the Jujuy Demonstration Project (JDP) carried out between 2012 and 2014. After a positive HPV-test, cytology is used as triage method. Read More

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http://dx.doi.org/10.1186/s12885-019-5583-7DOI Listing

Advanced assessment of migration and invasion of cancer cells in response to mifepristone therapy using double fluorescence cytochemical labeling.

BMC Cancer 2019 Apr 24;19(1):376. Epub 2019 Apr 24.

Experimental Pathology Unit, Department of Pathology, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Qc, H3A 2B4, Canada.

Background: Previous work in our laboratory demonstrated that antiprogestin mifepristone impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in their cellular morphology. In this study, we further assess the anti-metastatic properties of mifepristone, by studying whether cytostatic doses of the drug can inhibit the migration and invasion of various cancer cell lines using a double fluorescence cytochemical labeling approach.

Methods: Cell lines representing cancers of the ovary (SKOV-3), breast (MDA-MB-231), glia (U87MG), or prostate (LNCaP) were treated with cytostatic concentrations of mifepristone. Read More

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http://dx.doi.org/10.1186/s12885-019-5587-3DOI Listing

Follow-up care after treatment for prostate cancer: evaluation of a supported self-management and remote surveillance programme.

BMC Cancer 2019 Apr 23;19(1):368. Epub 2019 Apr 23.

University of Southampton, School of Health Sciences and University Hospital Southampton NHS Foundation Trust, Highfield, Southampton, SO17 1BJ, UK.

Background: Alternative models of cancer follow-up care are needed to ameliorate pressure on services and better meet survivors' long-term needs. This paper reports an evaluation of a service improvement initiative for the follow-up care of prostate cancer patients based on remote monitoring and supported self-management.

Methods: This multi-centred, historically controlled study compared patient reported outcomes of men experiencing the new Programme with men experiencing a traditional clinic appointment model of follow-up care, who were recruited in the period immediately prior to the introduction of the Programme. Read More

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http://dx.doi.org/10.1186/s12885-019-5561-0DOI Listing

HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports.

BMC Cancer 2019 Apr 23;19(1):375. Epub 2019 Apr 23.

Department of Pathology, Institut Curie, 75005, Paris, France.

Background: Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining. Ovarian metastasis from cervical cancer is a rare phenomenon, the mechanism of dissemination remains unclear. The diagnosis of metastasis may be difficult to establish when the ovarian neoplasm presents features consistent with primary tumor. Read More

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http://dx.doi.org/10.1186/s12885-019-5582-8DOI Listing

Intratumoral heterogeneity of EGFR-activating mutations in advanced NSCLC patients at the single-cell level.

BMC Cancer 2019 Apr 23;19(1):369. Epub 2019 Apr 23.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, People's Republic of China.

Background: Intratumoral epidermal growth factor receptor (EGFR) mutational heterogeneity is yet controversial in non-small cell lung cancer (NSCLC) patients. Single-cell analysis provides the genetic profile of single cancer cells and an in-depth understanding of the heterogeneity of a tumor.

Methods: Firstly, single H1975 cells harboring the EGFR L858R mutation were submitted to flow cytometry isolation, nested polymerase chain reaction (nested-PCR) amplification, and direct DNA sequencing to assess the feasibility of single-cell direct DNA sequencing. Read More

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http://dx.doi.org/10.1186/s12885-019-5555-yDOI Listing

A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma.

BMC Cancer 2019 Apr 23;19(1):373. Epub 2019 Apr 23.

Department of Biological Science, Laboratório de Biologia Molecular do Câncer, UNIFESP, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669 - 11° andar, São Paulo, SP, 04039-032, Brazil.

Background: There is a paucity of plasma-based biomarkers that prospectively segregate the outcome of patients with head and neck squamous-cell carcinoma (HNSCC) treated with chemoradiation therapy (CRT). Plasma extracellular vesicles (EVs) might be an alternative source for discovery of new specific markers present in patients with HNSCC, which could help to re-direct patients to appropriate curative therapies without delay.

Methods: In order to identify new markers in plasma compartments, Cholerae toxin B chain (CTB) and Annexin V (AV) were used to isolate EVs from pooled plasma samples from patients with locally advanced HNSCC who responded (CR, n = 6) or presented incomplete response (NR, n = 6) to CRT. Read More

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http://dx.doi.org/10.1186/s12885-019-5565-9DOI Listing

Smoking status and subsequent gastric cancer risk in men compared with women: a meta-analysis of prospective observational studies.

BMC Cancer 2019 Apr 24;19(1):377. Epub 2019 Apr 24.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, Liaoning Province, China.

Background: Smoking is one of the well-established risk factors for gastric cancer incidence, yet whether men are more or equally susceptible to gastric cancer due to smoking compared with women is a matter of controversy. The aim of this study was to investigate and compare the effect of sex on gastric cancer risk associated with smoking.

Methods: We conducted a systemic literature search in MEDLINE, EMBASE, and the Cochrane CENTRAL databases to identify studies published from inception to December 2018. Read More

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http://dx.doi.org/10.1186/s12885-019-5601-9DOI Listing

Prostate cancer solitary metastasis to anal canal: case report and review of literature.

BMC Cancer 2019 Apr 23;19(1):374. Epub 2019 Apr 23.

Department of Urology, National Cancer Institute, 1 Santariskiu Str., LT-08406, Vilnius, Lithuania.

Background: Here we present the first cases of prostate cancer solitary metastasis to anal canal.

Case Presentation: A 67-year-old male patient underwent radical prostatectomy with ilio-obturator lymphonodectomy in 2016 due to poorly differentiated ductal adenocarcinoma (Gleason 4 + 5(40%) = 9) pT3bN0. Two months later increasing PSA rate was noted and the patient started adjuvant intermittent androgen deprivation therapy combined with radiotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5573-9DOI Listing

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis.

BMC Cancer 2019 Apr 23;19(1):372. Epub 2019 Apr 23.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, People's Republic of China.

Background: As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy in PT treatment.

Methods: We performed a comprehensive search of databases, including PubMed, Web of Science and the Cochrane Library. The outcomes of interest included the local recurrence (LR) rate, metastasis rate, disease-free survival rate and overall survival rate. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5585-5DOI Listing
April 2019
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Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial.

BMC Cancer 2019 Apr 23;19(1):371. Epub 2019 Apr 23.

University of Illinois at Urbana-Champaign, Champaign, USA.

Background: Many breast cancer survivors (BCS) report deficits in cognitive function. Physical activity (PA) has been associated with better processing speed and memory in healthy adults and thus may be a useful method for improving cognition in BCS. The purpose of this study was to examine the effects of an acute bout of PA on processing speed and spatial working memory in a sample of BCS. Read More

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http://dx.doi.org/10.1186/s12885-019-5589-1DOI Listing

Protein interaction disruption in cancer.

BMC Cancer 2019 Apr 23;19(1):370. Epub 2019 Apr 23.

Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.

Background: Most methods that integrate network and mutation data to study cancer focus on the effects of genes/proteins, quantifying the effect of mutations or differential expression of a gene and its neighbors, or identifying groups of genes that are significantly up- or down-regulated. However, several mutations are known to disrupt specific protein-protein interactions, and network dynamics are often ignored by such methods. Here we introduce a method that allows for predicting the disruption of specific interactions in cancer patients using somatic mutation data and protein interaction networks. Read More

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http://dx.doi.org/10.1186/s12885-019-5532-5DOI Listing

Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing
April 2019
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A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Maintenance of physical activity and sedentary behavior change, and physical activity and sedentary behavior change after an abridged intervention: Secondary outcomes from the ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: This brief report examines the maintenance of moderate to vigorous physical activity (MVPA) and sedentary behavior changes approximately 12 weeks after the delivery of the ACTIVATE Trial primary intervention (use of the Garmin Vivofit 2 activity tracker coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions). We also examine the efficacy of an abridged intervention (use of the Garmin Vivofit 2 only) in the waitlist control group.

Methods: A pre-post design was employed to examine the secondary aims of the ACTIVATE Trial (n = 80; mean age = 62 years). Read More

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http://dx.doi.org/10.1002/cncr.32142DOI Listing

Incidence and outcome after first molecular versus overt recurrence in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia included in the ALL Ph08 trial from the Spanish PETHEMA Group.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Hematology, ICO Badalona-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Autonomous University of Barcelona, Badalona, Spain.

Background: Disease recurrence occurs in 20% to 40% of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who are treated with chemotherapy and tyrosine kinase inhibitors (TKIs). In the current study, the authors report the incidence, treatment, and outcome after first disease recurrence in young and older adults treated in the ALL Ph08 trial (ClinicalTrials.gov identifier NCT01491763). Read More

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http://dx.doi.org/10.1002/cncr.32156DOI Listing

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Background: Over 96% of high-grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore and/or reactivate the p53 pathway have been challenging. By contrast, p63, which shares many of the downstream targets and functions of p53, is rarely mutated in cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32053
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http://dx.doi.org/10.1002/cncr.32053DOI Listing
April 2019
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Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 ( Lu-J591) for metastatic castration-resistant prostate cancer.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

Background: Prostate cancer is radiosensitive. Prostate-specific membrane antigen (PSMA) is selectively overexpressed on advanced, castration-resistant tumors. Lutetium-177-labeled anti-PSMA monoclonal antibody J591 ( Lu-J591) targets prostate cancer with efficacy and dose-response/toxicity data when delivered as a single dose. Read More

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http://dx.doi.org/10.1002/cncr.32072DOI Listing

A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486 combined with the histone deacetylase inhibitor romidepsin in advanced solid tumors with dose expansion to further evaluate pharmacodynamics and possible clinical benefit of the recommended phase 2 dose (RP2D).

Methods: This was a phase 1 study with a 3 + 3 dose-escalation design and an expansion phase for patients with virally mediated cancers. Read More

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http://dx.doi.org/10.1002/cncr.32138DOI Listing

Fertility-related experiences after breast cancer diagnosis in the Sister and Two Sister Studies.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability.

Methods: A nationwide sample of US women diagnosed with breast cancer before age 45 years completed a survey assessing the prevalence of fertility counseling. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32126
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http://dx.doi.org/10.1002/cncr.32126DOI Listing
April 2019
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Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using a large database approach.

Methods: The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32115
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http://dx.doi.org/10.1002/cncr.32115DOI Listing
April 2019
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Trends in pediatric thyroid cancer incidence in the United States, 1998-2013.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Background: Pediatric differentiated thyroid cancer (DTC) rates have increased over time in the United States and worldwide. Improvements in imaging for the diagnosis of DTC have been hypothesized as a potential driver of these increases. This study stratifies temporal trends in pediatric DTC by stage and tumor size to assess whether rates of large, late-stage cancers, which are likely to be clinically meaningful, are increasing over time. Read More

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http://dx.doi.org/10.1002/cncr.32125DOI Listing

We cannot ignore the real component of the rise in thyroid cancer incidence.

Authors:
David Goldenberg

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.32123DOI Listing

The American Joint Committee on Cancer turns 60.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

American Joint Committee on Cancer, Chicago, Illinois.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32159
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http://dx.doi.org/10.1002/cncr.32159DOI Listing
April 2019
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Children and thyroid cancer: Interpreting troubling trends.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

The VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, Vermont.

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http://dx.doi.org/10.1002/cncr.32124DOI Listing

The role of cancer in marijuana and prescription opioid use in the United States: A population-based analysis from 2005 to 2014.

Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.

Background: For patients with cancer, marijuana may be an alternative to prescription opioid analgesics. This study analyzed self-reported marijuana and prescription opioid use among people with cancer over a 10-year time period.

Methods: Population-based data sets from the US National Health and Nutrition Examination Survey between 2005 and 2014 were compiled for respondents aged 20 to 60 years. Read More

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http://dx.doi.org/10.1002/cncr.32059DOI Listing

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.

BMC Cancer 2019 04 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5568-6DOI Listing
April 2019
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Imaging biomarkers for well and moderate hepatocellular carcinoma: preoperative magnetic resonance image and histopathological correlation.

BMC Cancer 2019 Apr 18;19(1):364. Epub 2019 Apr 18.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.

Background: Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

Methods: This study included one hundred and fifty-six patients with solitary HCC. Preoperative gadoxetic acid-enhanced MRI findings were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12885-019-5574-8DOI Listing

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow.

BMC Cancer 2019 Apr 18;19(1):365. Epub 2019 Apr 18.

Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Background: Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains proteins associated with the tumor microenvironment. Read More

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http://dx.doi.org/10.1186/s12885-019-5547-yDOI Listing

Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma.

BMC Cancer 2019 Apr 16;19(1):360. Epub 2019 Apr 16.

Department of Urology, West China Hospital, Sichuan University, Chengdu, People's Republic of China, 610041.

Background: In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor. Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1186/s12885-019-5578-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469103PMC
April 2019
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Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy.

BMC Cancer 2019 Apr 16;19(1):358. Epub 2019 Apr 16.

Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Background: Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first induction chemotherapy in patients with acute leukemia. We also compared outcomes of prophylactic micafungin with those of prophylactic posaconazole in acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1186/s12885-019-5557-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469030PMC
April 2019
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Health-related quality of life as an endpoint in oncology phase I trials: a systematic review.

BMC Cancer 2019 Apr 16;19(1):361. Epub 2019 Apr 16.

Methodology and Quality of Life in Oncology Unit, INSERM UMR 1098, University Hospital of Besançon, Besançon, France.

Background: Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of this study is to review the phase I in oncology which used HRQoL as endpoint. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5579-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469065PMC
April 2019
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Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.

BMC Cancer 2019 Apr 16;19(1):357. Epub 2019 Apr 16.

Inova Children's Hospital, Falls Church, VA, USA.

Background: Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective therapy. Genetic variation contributes to a wide range of response and toxicity related to chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5474-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466653PMC
April 2019
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Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome.

BMC Cancer 2019 Apr 16;19(1):362. Epub 2019 Apr 16.

Department of Gastroenterology and Endocrinology, University Hospital Marburg, Baldinger Strasse, 35043, Marburg, Germany.

Background: Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.

Methods: We retrospectively analyzed 51 patients with GEP-NEN and bronchopulmonary NEN excluding small cell lung cancer. Read More

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http://dx.doi.org/10.1186/s12885-019-5559-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469052PMC
April 2019
1 Read

Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation.

Authors:
Duan Chu Lai Wei

BMC Cancer 2019 Apr 16;19(1):359. Epub 2019 Apr 16.

College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing, China.

Background: Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily neutral. Read More

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http://dx.doi.org/10.1186/s12885-019-5572-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469204PMC

Feasibility of dynamic risk assessment for patients with repeated trans-arterial chemoembolization for hepatocellular carcinoma.

BMC Cancer 2019 Apr 16;19(1):363. Epub 2019 Apr 16.

Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

Background: Hepatoma arterial-embolization prognostic (HAP) score and its modifications (modified HAP [mHAP] and mHAP-II), consisting of some or all of the following factors of tumor size, number, alpha-fetoprotein, bilirubin, and serum albumin, have been found to predict outcomes after trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We investigated the feasibility of using HAP-related risk scores for dynamic risk assessment during repeated TACE.

Methods: A total of 619 HCC patients treated with TACE from two institutions between 2003 and 2010 were included. Read More

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http://dx.doi.org/10.1186/s12885-019-5495-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469056PMC

Erratum.

Authors:

Cancer 2019 May 5;125(9):1571. Epub 2018 Nov 5.

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http://dx.doi.org/10.1002/cncr.31703DOI Listing

Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells.

BMC Cancer 2019 Apr 15;19(1):356. Epub 2019 Apr 15.

Departamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas (IIBO), Universidad Nacional Autonoma de Mexico (UNAM), 04510 Ciudad de Mexico (CDMX), Mexico, Mexico.

Background: Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been well characterized in MCF7 luminal A breast cancer cells. The GR activates a variety of protective mechanisms, such as inhibitors of apoptosis proteins (IAPs). Read More

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http://dx.doi.org/10.1186/s12885-019-5563-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466787PMC
April 2019
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Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways.

BMC Cancer 2019 Apr 15;19(1):354. Epub 2019 Apr 15.

Department of Pathology, Saint Louis University, 1100 South Grand Boulevard, St. Louis, MO, 63104, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metastasis and aggressive phenotype. Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT-1) showed potential oncogenic roles in different cancers, however its role in HNSCC is not known. Read More

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http://dx.doi.org/10.1186/s12885-019-5562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466688PMC
April 2019
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Bilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report.

BMC Cancer 2019 Apr 15;19(1):355. Epub 2019 Apr 15.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rarer, which usually affects the choroid and iris. To the best of our knowledge, ciliary body metastasis of systemic MCL has not been reported. Read More

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http://dx.doi.org/10.1186/s12885-019-5530-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466781PMC
April 2019
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Relative efficacy of interventions in the treatment of second-line non-small cell lung cancer: a systematic review and network meta-analysis.

BMC Cancer 2019 Apr 15;19(1):353. Epub 2019 Apr 15.

Ohio State University Medical Center, Columbus, OH, USA.

Background: Locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed after first-line treatment has a poor prognosis. Recent randomized clinical trials (RCTs) have demonstrated survival benefits of alternative treatments to docetaxel. However, information is lacking on which patients benefit the most and what drug or regimen is optimal. Read More

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http://dx.doi.org/10.1186/s12885-019-5569-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466705PMC
April 2019
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Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The outcome of older patients with newly diagnosed, Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) is poor. The combination of targeted therapy with low-intensity chemotherapy is safe and effective. The objective of the current analysis was to compare the outcome of patients who received a combination of inotuzumab ozogamicin plus low-intensity chemotherapy (mini-hyperfractionated cyclophosphamide, vincristine, and dexamethasone [mini-HCVD]) with or without blinatumomab versus the outcome of those who received the standard, intensive, hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HCVAD) regimen. Read More

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http://dx.doi.org/10.1002/cncr.32139DOI Listing
April 2019
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Work-related medical rehabilitation in patients with cancer-Postrehabilitation results from a cluster-randomized multicenter trial.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Institute for Social Medicine and Epidemiology, University of Lubeck, Lubeck, Germany.

Background: Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psychosocial groups, and intensified social counseling. The authors tested the effectiveness of a work-related medical rehabilitation program compared with conventional medical rehabilitation using a cluster-randomized multicenter trial (German Clinical Trial Register: DRKS00007770). Read More

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http://dx.doi.org/10.1002/cncr.32131DOI Listing

Is there still a role for stem cell transplantation in multiple myeloma?

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

High-dose chemotherapy and autologous stem cell transplantation (ASCT) are a standard of care for transplant-eligible patients with newly diagnosed multiple myeloma (MM). The introduction of novel agents, which range from immunomodulatory drugs and proteasome inhibitors to monoclonal antibodies and have now been integrated into both induction and salvage regimens, has dramatically revolutionized the treatment landscape of MM and challenged the role of high-dose chemotherapy and ASCT in treating MM. These advances have led to a number of provocative questions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32060
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http://dx.doi.org/10.1002/cncr.32060DOI Listing
April 2019
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Pathfinders in oncology from the end of the 19th century to the first description of Ewing sarcoma.

Authors:
Steven I Hajdu

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Pathology Consultants, Westlake Village, California.

During the period 1884 to 1922, the only option in cases of operable cancers was radical surgery, and only a minority of patients were cured. Sporadic attempts were made to treat inoperable cancer patients with bacterial toxins; however, with the discovery of x-ray and radium, the era of radiation treatment as an alternative to surgery began. The discovery of transmissible cancers and experimental growth of cancer cells offered new information and not only led to a better understanding of the cellular composition of cancers but also yielded important information that ultimately paved the way to chemotherapy. Read More

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http://dx.doi.org/10.1002/cncr.32086DOI Listing

Ambulatory status after surgical and nonsurgical treatment for spinal metastasis.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Decisions for operative or nonoperative management remain challenging for patients with spinal metastases, especially when life expectancy and quality of life are not easily predicted. This study evaluated the effects of operative and nonoperative management on maintenance of ambulatory function and survival for patients treated for spinal metastases.

Methods: Propensity matching was used to yield an analytic sample in which operatively and nonoperatively treated patients were similar with respect to key baseline covariates. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32140
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http://dx.doi.org/10.1002/cncr.32140DOI Listing
April 2019
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Family communication and patient distress after germline genetic testing in individuals with pancreatic ductal adenocarcinoma.

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Germline genetic testing currently is recommended for patients with pancreatic ductal adenocarcinoma (PDAC). In the current study, the authors assessed how often results are communicated to first-degree relatives within 3 months and the emotional impact of testing on patients.

Methods: A total of 148 patients who were newly diagnosed with PDAC and who had undergone testing of 32 cancer susceptibility genes at 3 academic centers were selected; 71% participated. Read More

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http://dx.doi.org/10.1002/cncr.32077DOI Listing
April 2019
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