52,655 results match your criteria Cancer[Journal]


Microbiota and immune cell interplay.

Authors:
Anna Dart

Nat Rev Cancer 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cancer, .

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http://dx.doi.org/10.1038/s41568-019-0122-zDOI Listing
February 2019

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer.

BMC Cancer 2019 Feb 19;19(1):160. Epub 2019 Feb 19.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, Rm 3A46, Amsterdam, 1081, HV, the Netherlands.

Background: The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, but has not yet been validated in hospitalized patients with advanced cancer, although the DOS is commonly used in this setting in daily practice. The aim of this study was to evaluate the accuracy of the DOS in hospitalized patients with advanced cancer using the revised version of the Delirium Rating Scale (DRS-R) as the gold standard. Read More

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http://dx.doi.org/10.1186/s12885-019-5351-8DOI Listing
February 2019

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.

BMC Cancer 2019 Feb 18;19(1):157. Epub 2019 Feb 18.

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

Background: Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical importance.

Results: In this study we tested expression and performed pharmacological characterization of the calcitonin receptor (CTR) as well as other members of the calcitonin family of receptors in high-grade glioma (HGG) cell lines derived from individual patient tumours, cultured in defined conditions. Read More

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http://dx.doi.org/10.1186/s12885-019-5369-yDOI Listing
February 2019

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro.

BMC Cancer 2019 Feb 18;19(1):158. Epub 2019 Feb 18.

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, 97331, USA.

Background: Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utilizing autocrine and/or paracrine hormones as growth factors and/or promoters of angiogenesis to facilitate progression and metastasis. While many of these factors and their actions on tumor growth are characterized, some tumor-derived neuropeptides remain unexplored. Read More

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http://dx.doi.org/10.1186/s12885-019-5363-4DOI Listing
February 2019

Stromal cell ratio based on automated image analysis as a predictor for platinum-resistant recurrent ovarian cancer.

BMC Cancer 2019 Feb 18;19(1):159. Epub 2019 Feb 18.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

Background: Identifying high-risk patients for platinum resistance is critical for improving clinical management of ovarian cancer. We aimed to use automated image analysis of hematoxylin & eosin (H&E) stained sections to identify the association between microenvironmental composition and platinum-resistant recurrent ovarian cancer.

Methods: Ninety-one patients with ovarian cancer containing the data of automated image analysis for H&E histological sections were initially reviewed. Read More

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http://dx.doi.org/10.1186/s12885-019-5343-8DOI Listing
February 2019

Erratum.

Authors:

Cancer 2019 Mar 26;125(5):821. Epub 2018 Dec 26.

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http://dx.doi.org/10.1002/cncr.31929DOI Listing

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients.

BMC Cancer 2019 Feb 15;19(1):156. Epub 2019 Feb 15.

Department of Urology, Yamagata University, 2-2-2, Iida-nishi, Yamagata, 990-9585, Japan.

Background: We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC).

Methods: We retrospectively evaluated 118 patients who received CBZ for docetaxel-resistant CRPC in 10 university hospitals in Japan between 2014 and 2016. The rate of decrease of prostate-specific antigen (PSA), adverse events, progression-free survival (PFS), and overall survival (OS) were compared between patients receiving initially high (≥22. Read More

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http://dx.doi.org/10.1186/s12885-019-5342-9DOI Listing
February 2019
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Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells.

BMC Cancer 2019 Feb 15;19(1):153. Epub 2019 Feb 15.

Australian Institute for Bioengineering and Nanotechnology (Building 75), The University of Queensland, Cooper Rd., St Lucia, Brisbane, QLD, 4072, Australia.

Background: Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). Previously, we reported that colon and breast cancer stem cells (CSCs) expressed much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant to immune attack.

Methods: We investigated the underlining mechanism of PD-L1 increase in colon CSCs, with a special focus on the effect of insulin and epithelial growth factor (EGF), the two fundamental components to sustain the metabolism and stemness in the culture of CSCs. Read More

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http://dx.doi.org/10.1186/s12885-019-5364-3DOI Listing
February 2019
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Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center.

BMC Cancer 2019 Feb 15;19(1):154. Epub 2019 Feb 15.

Department of preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

Background: The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, what are the levels of the women's awareness /behavior toward available screening tools?

Methods: An individual cancer risk assessment questionnaire has been developed in the Department of Preventive Oncology, which questions the medical history, health behaviors and cancer awareness, as well as their behavior toward available cancer screening tools.

Results: The mean age of the study population was 45. Read More

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http://dx.doi.org/10.1186/s12885-019-5350-9DOI Listing
February 2019
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Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients.

BMC Cancer 2019 Feb 15;19(1):155. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str, 40 06097, Halle/Saale, Germany.

Background: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12885-019-5327-8DOI Listing
February 2019
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Hyperprogression with immunotherapy: Is it real?

Authors:
Sanjay Popat

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1002/cncr.31997DOI Listing
February 2019

Hyperprogressive disease in early-phase immunotherapy trials: Clinical predictors and association with immune-related toxicities.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Background: A subset of patients treated with immune checkpoint inhibitors experience an accelerated tumor growth rate (TGR) in comparison with pretreatment kinetics; this is known as hyperprogression. This study assessed the relation between hyperprogressive disease (HPD) and treatment-related toxicity and clinical factors.

Methods: This study reviewed patients with solid tumors who were enrolled in early-phase immunotherapy trials at Princess Margaret Cancer Centre between August 2012 and September 2016 and had computed tomography scans in the pre-immunotherapy (reference) and on-immunotherapy (experimental) periods. Read More

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http://dx.doi.org/10.1002/cncr.31999DOI Listing
February 2019

Reply to The relationship between obesity in adolescence and pancreatic cancer in adulthood.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1002/cncr.32019DOI Listing
February 2019
1 Read

Association between primary language, a lack of mammographic screening, and later stage breast cancer presentation.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.

Background: Health determinants are known to influence the stage of breast cancer presentation, but it is unclear to what extent language affects stage. This study investigates whether non-English-speaking (NES) patients present at a later stage than their English-speaking (ES) counterparts and whether language is associated with mammographic screening.

Methods: This study was a retrospective, single-institution cohort analysis of women undergoing breast radiotherapy from 2012 to 2017 (n = 1057). Read More

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http://dx.doi.org/10.1002/cncr.32027DOI Listing
February 2019

The relationship between obesity in adolescence and pancreatic cancer in adulthood.

Authors:
Shih-Wei Lai

Cancer 2019 Feb 15. Epub 2019 Feb 15.

College of Medicine, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1002/cncr.32018DOI Listing
February 2019
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"You probably can't feel as safe as normal women": Hispanic women's reactions to breast density notification.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.

Background: Patient advocacy has led to state-level legislative mandates for the release of personal mammographic breast density information to women undergoing screening mammography. More research is needed to understand the impact of this information on women's perceptions and mammography screening behavior.

Methods: Semistructured interviews were conducted in English and Spanish with 24 self-identified Hispanic women who had undergone at least 1 mammogram since breast density notification was enacted in New York State. Read More

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http://dx.doi.org/10.1002/cncr.32002DOI Listing
February 2019
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The impact of psychosocial stress and stress management on immune responses in patients with cancer.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry and Behavioral Sciences and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida.

The range of psychosocial stress factors/processes (eg, chronic stress, distress states, coping, social adversity) were reviewed as they relate to immune variables in cancer along with studies of psychosocial interventions on these stress processes and immune measures in cancer populations. The review includes molecular, cellular, and clinical research specifically examining the effects of stress processes and stress-management interventions on immune variables (eg, cellular immune function, inflammation), which may or may not be changing directly in response to the cancer or its treatment. Basic psychoneuroimmunologic research on stress processes (using animal or cellular/tumor models) provides leads for investigating biobehavioral processes that may underlie the associations reported to date. Read More

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http://doi.wiley.com/10.1002/cncr.31943
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http://dx.doi.org/10.1002/cncr.31943DOI Listing
February 2019
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Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years. Read More

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http://dx.doi.org/10.1002/cncr.31995DOI Listing
February 2019
1 Read

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study.

BMC Cancer 2019 02 15;19(1):152. Epub 2019 Feb 15.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3. Read More

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http://dx.doi.org/10.1186/s12885-019-5357-2DOI Listing
February 2019

Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study.

BMC Cancer 2019 Feb 14;19(1):150. Epub 2019 Feb 14.

Department of Oncology, Cumming School of Medicine, University of Calgary, Tom Baker Cancer Centre, 1331 29 St NW, Calgary, Alberta, T2N 4N2, Canada.

Background: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy.

Methods: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Read More

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http://dx.doi.org/10.1186/s12885-019-5349-2DOI Listing
February 2019
1 Read

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice.

BMC Cancer 2019 Feb 14;19(1):151. Epub 2019 Feb 14.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding events. The objectives of this study were to characterize the incidence, clinical consequences, and economic costs of CIT in current US clinical practice.

Methods: A retrospective cohort design and data from two US private healthcare claims repositories (01/2010-12/2016) were employed. Read More

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http://dx.doi.org/10.1186/s12885-019-5354-5DOI Listing
February 2019
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Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus.

BMC Cancer 2019 Feb 13;19(1):144. Epub 2019 Feb 13.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Panjiayuan Nanli 17#, Chaoyang District, 100021, People's Republic of China.

Background: Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few studies have focused on postoperative long-term survival of RCC patients exclusively with RVTT. Our aim was to investigate the independent prognostic factors for locally advanced RCC with RVTT in China. Read More

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http://dx.doi.org/10.1186/s12885-019-5359-0DOI Listing
February 2019
1 Read

Sleep disorders associated with risk of prostate cancer: a population-based cohort study.

BMC Cancer 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.

Background: Disrupted sleep rhythms may lead to cancer development. We conducted a population-based cohort study to evaluate the incidence and risk of prostate cancer in patients with sleep disorders (SDs).

Methods: Patients newly diagnosed with SDs between 2000 and 2010 were enrolled from the Taiwan Longitudinal Health Insurance Database. Read More

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http://dx.doi.org/10.1186/s12885-019-5361-6DOI Listing
February 2019
1 Read

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation.

BMC Cancer 2019 Feb 13;19(1):148. Epub 2019 Feb 13.

Division of Pulmonology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. However, hypoxia-induced changes in the expression and function of candidate stem cell markers and their possible molecular mechanism is still not understood.

Methods: Lung cell lines were analyzed in normoxic or hypoxic conditions. Read More

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http://dx.doi.org/10.1186/s12885-019-5360-7DOI Listing
February 2019

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up.

BMC Cancer 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Ultrasound, Beijing Tian Tan Hospital, Capital Medical University, No. 119 West Road of South 4th Ring Road, Fengtai District, Beijing, 100160, China.

Background: The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a 2-year follow up study was investigated.

Methods: This retrospective study evaluated 194 non-functioning solid benign TNs of 103 patients. The TNs were categorized as small (≤5 ml), medium (5. Read More

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http://dx.doi.org/10.1186/s12885-019-5338-5DOI Listing
February 2019
1 Read

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis.

BMC Cancer 2019 Feb 13;19(1):145. Epub 2019 Feb 13.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.

Background: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases.

Methods: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5331-zDOI Listing
February 2019
2 Reads

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.

BMC Cancer 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Background: Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5323-zDOI Listing
February 2019
2 Reads

Haploinsufficiency of UNC13D increases the risk of lymphoma.

Cancer 2019 Feb 13. Epub 2019 Feb 13.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.

Background: Experimental models have demonstrated that immune surveillance by cytotoxic lymphocytes can protect from spontaneous neoplasms and cancer. In humans, defective lymphocyte cytotoxicity is associated with the development of hemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome. However, to the best of the authors' knowledge, the degree to which human lymphocyte cytotoxicity protects from cancer remains unclear. Read More

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http://dx.doi.org/10.1002/cncr.32011DOI Listing
February 2019

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.

Nat Rev Cancer 2019 Feb 12. Epub 2019 Feb 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success in the treatment of different cancer types. Yet, only a subset of patients derive clinical benefit. It is thus critical to understand the determinants driving response, resistance and adverse effects. Read More

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http://dx.doi.org/10.1038/s41568-019-0116-xDOI Listing
February 2019

Hematologic markers of distant metastases and poor prognosis in gynecological cancers.

BMC Cancer 2019 Feb 12;19(1):141. Epub 2019 Feb 12.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, 11941, Jordan.

Background: Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the carcinogenesis process including metastasis. The high neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) were found to be associated with poor survival rates in the majority of solid tumors. Read More

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http://dx.doi.org/10.1186/s12885-019-5326-9DOI Listing
February 2019

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases.

BMC Cancer 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Oncology, Huashan Hospital Fudan University, Shanghai, China.

Background: The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples from lung adenocarcinoma (LAC) patients with leptomeningeal metastases (LM).

Methods: Paired CSF cell free DNA (cfDNA), CSF cells, plasma and formalin-fixed and paraffin-embedded (FFPE) samples of primary tumors were collected from 29 LAC patients with LM to detect the mutations by different NGS pipelines. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5348-3DOI Listing
February 2019
2 Reads

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort.

BMC Cancer 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Danish Colorectal Cancer Center South, Vejle Hospital, Vejle, Denmark.

Background: Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-based cohort of patients with stage II CC.

Methods: PD-L1 expression on tumour cells was evaluated by immunohistochemistry in 572 colon cancers. Read More

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http://dx.doi.org/10.1186/s12885-019-5345-6DOI Listing
February 2019

Impact of healthy lifestyles on cancer risk in the Chinese population.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Although cancer has become one of the leading health burdens, to the authors' knowledge, evidence regarding its relationship with a healthy lifestyle in the Chinese population remains limited.

Methods: The authors evaluated the association between clustering of healthy lifestyle factors and cancer risk using 3 prospective cohort studies with 101,208 Chinese adults from the general population. Hazard ratios (HRs) and corresponding 95% confidential intervals (95% CIs) related to healthy lifestyle factors were calculated using Cox proportional hazard models, and population-attributable risk percentages were estimated further. Read More

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http://dx.doi.org/10.1002/cncr.31971DOI Listing
February 2019

Reply to Tumor-associated macrophages: "Good cop-bad cop".

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1002/cncr.32015DOI Listing
February 2019

The distribution and prevalence of human papillomavirus in women in mainland China.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. Read More

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http://doi.wiley.com/10.1002/cncr.32003
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http://dx.doi.org/10.1002/cncr.32003DOI Listing
February 2019
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Usefulness of surveillance imaging in patients with head and neck cancer who are treated with definitive radiotherapy.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The current study was performed to assess the efficacy of surveillance imaging in patients with head and neck cancer (HNC) who are treated definitively with radiotherapy.

Methods: Eligible patients included those with a demonstrable disease-free interval (≥1 follow-up imaging procedure without evidence of disease and a subsequent visit/imaging procedure) who underwent treatment of HNC from 2000 through 2010.

Results: A total of 1508 patients were included. Read More

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http://dx.doi.org/10.1002/cncr.31983DOI Listing
February 2019

The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.32008DOI Listing
February 2019

Targeting autophagy using natural compounds for cancer prevention and therapy.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Lake Erie College of Osteopathic Medicine, Bradenton, Florida.

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation of damaged proteins and organelles in eukaryotic cells. Autophagy also plays a key role in various tissue processes and immune responses and in the regulation of inflammation. Read More

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http://dx.doi.org/10.1002/cncr.31978DOI Listing
February 2019

Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut.

Background: Treatment at high-volume surgical facilities (HVSFs) provides a survival benefit for patients with head and neck squamous cell carcinomas (HNSCCs); however, it is unknown what role postoperative radiation therapy (PORT) plays in achieving the improved outcomes.

Methods: From the National Cancer Database, 6844 patients with locally advanced invasive HNSCCs of the oral cavity, oropharynx, larynx, and hypopharynx who underwent definitive surgery with PORT between 2004 and 2013 were identified. HVSFs were those in the top percentile for annual case volume during this period. Read More

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http://dx.doi.org/10.1002/cncr.32001DOI Listing
February 2019

Tumor-associated macrophages: "Good cop-bad cop".

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1002/cncr.32016DOI Listing
February 2019

Cyclooxygenase-2 in gastrointestinal malignancies.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal transduction pathways, which contribute to the metastatic properties of gastrointestinal (GI) malignancies. Although COX-1 is constitutively active, COX-2 is upregulated by cytokines, growth factors, and mitogen. Read More

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http://dx.doi.org/10.1002/cncr.32010DOI Listing
February 2019

Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy: A psychological perspective.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.31980DOI Listing
February 2019
1 Read

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis.

BMC Cancer 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

Departments of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Background: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Read More

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http://dx.doi.org/10.1186/s12885-019-5347-4DOI Listing
February 2019
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Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study.

BMC Cancer 2019 Feb 11;19(1):139. Epub 2019 Feb 11.

Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK.

Background: Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours of all behaviours, while others only cover malignant neoplasms. Read More

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http://dx.doi.org/10.1186/s12885-019-5344-7DOI Listing
February 2019
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Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling.

BMC Cancer 2019 Feb 11;19(1):137. Epub 2019 Feb 11.

Centre de recherche en organogénèse expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, QC, Québec, Canada.

Background: Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer progression. Epithelial-mesenchymal transition (EMT) is a key feature of metastatic cells. However, the mechanism by which CAFs induce EMT program in bladder cancer cells remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-019-5353-6DOI Listing
February 2019

Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy.

BMC Cancer 2019 Feb 11;19(1):135. Epub 2019 Feb 11.

Department of Surgery, Tawam Hospital, AlAin, United Arab Emirates.

Background: Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5' promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen and progesterone receptor-DNA binding domains as direct response elements to estrogen and progesterone that are linked to breast functions or steroid regulation. The study was designed to determine the role of TFF3 in breast cancer chemoresistance with the aim of establishing TFF3 expression as a biomarker for drug resistance. Read More

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http://dx.doi.org/10.1186/s12885-019-5316-yDOI Listing
February 2019