55,459 results match your criteria Cancer[Journal]


Access and socioeconomic status play an important role in outcomes for African American patients with prostate cancer.

Cancer 2020 Jul 9. Epub 2020 Jul 9.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/cncr.33063DOI Listing

US Food and Drug Administration approvals for Bruton tyrosine kinase inhibitors in patients with chronic lymphocytic leukemia: Potential inefficiencies in trial design and evidence generation.

Cancer 2020 Jul 9. Epub 2020 Jul 9.

Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California.

The US Food and Drug Administration granted acalabrutinib approval as the second Bruton tyrosine kinase (BTK) inhibitor to treat patients with chronic lymphocytic leukemia and small lymphocytic lymphoma as monotherapy or in combination with obinutuzumab. This approval was based on 2 phase 3 trials: ELEVATE-TN and ASCEND. There are several concerns with the design of these trials, including suboptimal treatment of patients in the control arm, expansion of the trial population, and lack of data regarding efficacy or tolerability compared with ibrutinib, a first-in-class drug. Read More

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http://dx.doi.org/10.1002/cncr.33058DOI Listing

Equal access to health care reduces racial disparities in prostate cancer outcomes.

Cancer 2020 Jul 9. Epub 2020 Jul 9.

Department of Urology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/cncr.33065DOI Listing

Meta-analysis examining overall survival in patients with pancreatic cancer treated with second-line 5-fluorouracil and oxaliplatin-based therapy after failing first-line gemcitabine-containing therapy: effect of performance status and comparison with other regimens.

BMC Cancer 2020 Jul 8;20(1):633. Epub 2020 Jul 8.

Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Background: Pancreatic cancer has a poor prognosis and few choices of therapy. For patients with adequate performance status, FOLFIRINOX or gemcitabine plus nab-paclitaxel are preferred first-line treatment. 5-Fluorouracil (5-FU)-based therapy (e. Read More

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http://dx.doi.org/10.1186/s12885-020-07110-xDOI Listing

CCL18-NIR1 promotes oral cancer cell growth and metastasis by activating the JAK2/STAT3 signaling pathway.

BMC Cancer 2020 Jul 8;20(1):632. Epub 2020 Jul 8.

Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Background: Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of oral cancer cells; however, the cognate receptors of CCL18 involved in the pathogenesis of oral squamous cell carcinoma (OSCC) have not yet been identified. This study aimed to investigate the molecular mechanisms which underlie promotive effects of CCL18 on OSCC progression by binding to functional receptors. Read More

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http://dx.doi.org/10.1186/s12885-020-07073-zDOI Listing

Design of the PROstate cancer follow-up care in Secondary and Primary hEalth Care study (PROSPEC): a randomized controlled trial to evaluate the effectiveness of primary care-based follow-up of localized prostate cancer survivors.

BMC Cancer 2020 Jul 8;20(1):635. Epub 2020 Jul 8.

Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066, Amsterdam, CX, The Netherlands.

Background: In its 2006 report, From cancer patient to cancer survivor: lost in transition, the U.S. Institute of Medicine raised the need for a more coordinated and comprehensive care model for cancer survivors. Read More

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http://dx.doi.org/10.1186/s12885-020-07112-9DOI Listing

Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells.

BMC Cancer 2020 Jul 8;20(1):634. Epub 2020 Jul 8.

Oncology Department, The First Affiliated Hospital, Chengdu Medical College, 278 Baoguang St, Xindu Distr, Chengdu, 610500, Sichuan, China.

Background: Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and autophagy in A549 cells treated with cisplatin.

Methods: SILAC proteomics was applied to obtain a panoramic view of cisplatin treatment in KRAS-mutant A549 cells. Read More

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http://dx.doi.org/10.1186/s12885-020-07111-wDOI Listing

Head & neck acinar cell carcinoma: a population-based study using the seer registry.

BMC Cancer 2020 Jul 8;20(1):631. Epub 2020 Jul 8.

Department of Oral & Maxillofacial Surgery and Oral Biomedical Engineering Laboratory Shanghai Stomatological Hospital, Fudan University, 356 Beijing East Road, Shanghai, 200001, People's Republic of China.

Background: To explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively.

Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975-2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Read More

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http://dx.doi.org/10.1186/s12885-020-07066-yDOI Listing

A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report.

BMC Cancer 2020 Jul 8;20(1):630. Epub 2020 Jul 8.

Oncology Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16th Airport Road, Guangzhou, 510405, Guangdong, China.

Background: Spinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There is currently a lack of consensus regarding post-operative treatment. Clinical data on the activity of systemic treatment like chemoradiotherapy and anti-angiogenic agents also remained scant. Read More

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http://dx.doi.org/10.1186/s12885-020-07061-3DOI Listing

The 3 B's of cancer care amid the COVID-19 pandemic crisis: "Be safe, be smart, be kind"-A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer.

Cancer 2020 Jul 8. Epub 2020 Jul 8.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Because of the national emergency triggered by the coronavirus disease 2019 (COVID-19) pandemic, government-mandated public health directives have drastically changed not only social norms but also the practice of oncologic medicine. Timely head and neck cancer (HNC) treatment must be prioritized, even during emergencies. Because severe acute respiratory syndrome coronavirus 2 predominantly resides in the sinonasal/oral/oropharyngeal tracts, nonessential mucosal procedures are restricted, and HNCs are being triaged toward nonsurgical treatments when cures are comparable. Read More

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http://dx.doi.org/10.1002/cncr.33031DOI Listing

A combination of enhanced recovery after surgery and prehabilitation pathways improves perioperative outcomes and costs for robotic radical prostatectomy.

Cancer 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, La Croix du Sud Hospital, Quint-Fonsegrives, France.

Background: An enhanced recovery after surgery (ERAS) pathway has shown benefit in oncologic surgery. However, literature is scarce regarding the impact of this pathway, alone or combined with prehabilitation (PreHab) programs, on outcomes after robot-assisted radical prostatectomy (RARP).

Methods: Included in this study were 507 consecutive patients undergoing RARP from 2014 to 2019. Read More

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http://dx.doi.org/10.1002/cncr.33061DOI Listing

Early posttherapy clearance of human papillomavirus and treatment response in cervical carcinoma.

Cancer 2020 Jul 8. Epub 2020 Jul 8.

Washington University Medical Center, St. Louis, Missouri.

Background: Among patients with cervical cancer, little is known about the significance of persistent human papillomavirus (HPV) expression after chemoradiation (CRT). This study evaluated associations between early posttreatment HPV clearance and patient outcomes with an added focus on the value of posttherapy positron emission tomography (PET) imaging.

Methods: Included patients underwent pretreatment testing indicating a high-risk HPV infection and posttreatment testing with a messenger RNA (mRNA)-based genital swab after CRT. Read More

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http://dx.doi.org/10.1002/cncr.33040DOI Listing

Effects of a mindfulness-based intervention on cancer-related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study.

Cancer 2020 Jul 8. Epub 2020 Jul 8.

Department of Imaging and Pathology, Catholic University of Leuven, Leuven, Belgium.

Background: Many breast cancer survivors suffer from cognitive complaints after cancer treatment, affecting their quality of life. The objective of this pilot study was to investigate the effect of a blended-care mindfulness-based intervention (MBI) on chemotherapy-related cognitive impairment and functional brain changes. Furthermore, correlations between changes in cognitive functioning and self-reported behavioral factors were investigated. Read More

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http://dx.doi.org/10.1002/cncr.33074DOI Listing

Metabolites going up in smoke.

Authors:
Ulrike Harjes

Nat Rev Cancer 2020 Jul 7. Epub 2020 Jul 7.

Nature Reviews Cancer, .

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http://dx.doi.org/10.1038/s41568-020-0289-3DOI Listing

In vivo functional screening for systems-level integrative cancer genomics.

Nat Rev Cancer 2020 Jul 7. Epub 2020 Jul 7.

Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München, Munich, Germany.

With the genetic portraits of all major human malignancies now available, we next face the challenge of characterizing the function of mutated genes, their downstream targets, interactions and molecular networks. Moreover, poorly understood at the functional level are also non-mutated but dysregulated genomes, epigenomes or transcriptomes. Breakthroughs in manipulative mouse genetics offer new opportunities to probe the interplay of molecules, cells and systemic signals underlying disease pathogenesis in higher organisms. Read More

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http://dx.doi.org/10.1038/s41568-020-0275-9DOI Listing

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun.

BMC Cancer 2020 Jul 7;20(1):629. Epub 2020 Jul 7.

Blood Cancer and Stem Cells, Division of Cancer and Stem Cells, School of Medicine, Nottingham Biodiscovery Institute, University of Nottingham, Room B209, University Park, Nottingham, NG7 2RD, UK.

Background: Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of the cytotoxic indole alkaloid Jerantinine B (JB), was examined in AML cells. Read More

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http://dx.doi.org/10.1186/s12885-020-07119-2DOI Listing

Impact of optimizing diagnostic workup and reducing the time to treatment in head and neck cancer.

Cancer 2020 Jul 7. Epub 2020 Jul 7.

Department of Otorhinolaryngology-Head and Neck Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Timely and efficient diagnostic workup of patients with head and neck cancer (HNC) is challenging. This observational study describes the implementation of an optimized multidisciplinary oncological diagnostic workup for patients with HNC and its impact on diagnostic and treatment intervals, survival, costs, and patient satisfaction.

Methods: All patients with newly diagnosed HNC who underwent staging and treatment at the Radboud University Medical Center were included. Read More

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http://dx.doi.org/10.1002/cncr.33037DOI Listing

Metabolism of immune cells in cancer.

Nat Rev Cancer 2020 Jul 6. Epub 2020 Jul 6.

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. In order to sustain prodigious anabolic needs, tumours employ a specialized metabolism that differs from untransformed somatic cells. Read More

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http://dx.doi.org/10.1038/s41568-020-0273-yDOI Listing

NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells.

BMC Cancer 2020 Jul 6;20(1):626. Epub 2020 Jul 6.

Department of Pathophysiology, Weifang Medical University, Weifang, 261053, China.

Background: The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F, member 2 (NR2F2) has been implicated in the development of breast cancer, however its contribution to insulin-induced EMT in breast cancer remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-020-07107-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336611PMC

Sarcoma epidemiology and cancer-related hospitalisation in Western Australia from 1982 to 2016: a descriptive study using linked administrative data.

BMC Cancer 2020 Jul 6;20(1):625. Epub 2020 Jul 6.

Health Economics and Data Analytics, School of Public Health, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia.

Background: Sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Epidemiological studies on sarcoma from Australia are lacking, as previous studies have focused on a sarcoma type (e.g. Read More

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http://dx.doi.org/10.1186/s12885-020-07103-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336405PMC

Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation.

BMC Cancer 2020 Jul 6;20(1):627. Epub 2020 Jul 6.

Research Center for Translational Medicine, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.

Background: Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through interaction with target gene p27. Read More

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http://dx.doi.org/10.1186/s12885-020-07118-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339532PMC
July 2020
3.362 Impact Factor

Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms.

BMC Cancer 2020 Jul 6;20(1):628. Epub 2020 Jul 6.

Department of Internal Medicine VIII, Department of Medical Oncology and Pneumology, University Hospital Tuebingen, University of Tuebingen, Otfried-Mueller-Strasse 10, 72076, Tuebingen, Baden-Wuerttemberg, Germany.

Background: Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic sites. Read More

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http://dx.doi.org/10.1186/s12885-020-07121-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339398PMC

Determining the impact of Medicaid expansion on cancer burden.

Cancer 2020 Jul 6. Epub 2020 Jul 6.

Collective Health Inc, San Francisco, California.

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http://dx.doi.org/10.1002/cncr.33039DOI Listing

The effect of Medicaid expansion among adults from low-income communities on stage at diagnosis in those with screening-amenable cancers.

Cancer 2020 Jul 6. Epub 2020 Jul 6.

Center for Community Health Integration, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Background: Several states have opted to expand Medicaid under the Patient Protection and Affordable Care Act (ACA), which offers insurance coverage to low-income individuals up to 138% of the federal poverty level. This expansion of Medicaid to a medically vulnerable population potentially can reduce cancer outcome disparities, especially among patients with screening-amenable cancers. The objective of the current study was to estimate the effect of Medicaid expansion on the percentage of adults from low-income communities with screening-amenable cancers who present with metastatic disease. Read More

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http://dx.doi.org/10.1002/cncr.32895DOI Listing

Tumours disrupt the immune scenery.

Authors:
Linda Gummlich

Nat Rev Cancer 2020 Jul 3. Epub 2020 Jul 3.

Editor, BMC Cancer, .

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http://dx.doi.org/10.1038/s41568-020-0286-6DOI Listing

The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma.

BMC Cancer 2020 Jul 3;20(1):624. Epub 2020 Jul 3.

CEA, DRF-Francois Jacob Institute, Research Division in Hematology and Immunology (SRHI), Saint-Louis Hospital, 1, avenue Claude Vellefaux, 75010, Paris, France.

Background: Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as first-line treatment, on the administration of the vascular endothelial growth factor (VEGF) neutralizing antibody termed Bevacizumab. Despite proven benefits, the expected results were not obtained for the majority of patients. Read More

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http://dx.doi.org/10.1186/s12885-020-07113-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333411PMC

Design and methods of a national, multicenter, randomized and controlled trial to assess the efficacy of a physical activity program to improve health-related quality of life and reduce fatigue in women with metastatic breast cancer: ABLE02 trial.

BMC Cancer 2020 Jul 3;20(1):622. Epub 2020 Jul 3.

Department of Cancer and Environment, Léon Bérard Cancer Center, 28 rue Laennec, 69008, Lyon, France.

Background: Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibility of a physical activity program has been demonstrated in this population, ABLE02 aims to assess the efficacy of a 6 month-physical activity program using connected devices to improve health-related quality of life and to reduce fatigue in women with metastatic breast cancer.

Methods: ABLE02 is a prospective, national, multicenter, randomized, controlled and open-label study. Read More

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http://dx.doi.org/10.1186/s12885-020-07093-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333295PMC

Incidence, prevalence, mortality, and causes of death in Waldenström macroglobulinemia: a nationwide, population-based cohort study.

BMC Cancer 2020 Jul 3;20(1):623. Epub 2020 Jul 3.

Division of Hematology-Oncology, Department of Internal Medicine, Kosin University College of Medicine, 262, Gamcheon-ro, Seo-gu, Busan, 49267, South Korea.

Background: The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes of death of patients with WM.

Methods: We used a national population-based database, operated by the Health Insurance Review and Assessment Service of the Korean government. Read More

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http://dx.doi.org/10.1186/s12885-020-07120-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333304PMC

Reply to Incidence of extrameningeal solitary fibrous tumors and Novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Adult Mesenchymal and Rare Tumor Unit, Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.33056DOI Listing

Novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Third Department of Surgery, First Faculty of Medicine, Charles University/Motol University Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.1002/cncr.33055DOI Listing

Incidence of extrameningeal solitary fibrous tumors.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiation Oncology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.33057DOI Listing

Fluctuating expression of miR-584 in primary and high-grade gastric cancer.

BMC Cancer 2020 Jul 2;20(1):621. Epub 2020 Jul 2.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Background: Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. Read More

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http://dx.doi.org/10.1186/s12885-020-07116-5DOI Listing

The impact on quality of life from informing diagnosis in patients with cancer: a systematic review and meta-analysis.

BMC Cancer 2020 Jul 2;20(1):618. Epub 2020 Jul 2.

Dermatology Department of Xiangya Hospital, Central SouthUniversity, No.87, Xiangya Road, Kaifu District, Changsha, 410000, Hunan Province, China.

Background: The aim of this study was to assess the impact on quality of life from informing patients with cancer of their diagnosis and disease status.

Method: We searched the follow databases, PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), PsycINFO, WEB OF SCIENCE, Embase, CBM (Chinese Biomedical Literature database), WANFANG database (Chinese Medicine Premier), and CNKI (China National Knowledge Infrastructure), using the following terms: neoplasm, cancer, tumor, tumor, carcinoma, disclosure, truth telling, breaking bad news, knowledge, knowing, awareness, quality of life, QOL. Pairs of reviewers independently screened documents and extracted the data, and the meta-analysis was performed using Revman 5. Read More

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http://dx.doi.org/10.1186/s12885-020-07096-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331248PMC

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization.

BMC Cancer 2020 Jul 2;20(1):619. Epub 2020 Jul 2.

Division of Hematology-Oncology, Department of Internal Medicine, Korea University School of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, South Korea.

Background: We assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclophosphamide with G-CSF or G-CSF alone.

Methods: We compared the clinical features of 173 non-Hodgkin's lymphoma patients who underwent autologous peripheral blood stem cell transplantation (auto-PBSCT). Additionally, we performed in vitro experiments to assess the changes in human bone marrow stromal cells (hBMSCs), which support the HSCs in the bone marrow (BM) niche, following cyclophosphamide or etoposide exposure. Read More

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http://dx.doi.org/10.1186/s12885-020-07102-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330970PMC

Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.

BMC Cancer 2020 Jul 2;20(1):617. Epub 2020 Jul 2.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Charitéplatz 1, 10117, Berlin, Germany.

Background: Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence. To target the driving forces of the tumor microevolution, we focused on synergistic drug combinations of selected compounds. Read More

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http://dx.doi.org/10.1186/s12885-020-07062-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331156PMC

PODXL might be a new prognostic biomarker in various cancers: a meta-analysis and sequential verification with TCGA datasets.

BMC Cancer 2020 Jul 2;20(1):620. Epub 2020 Jul 2.

Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Absract: BACKGROUND: Several studies have investigated the associations between the podocalyxin-like protein (PODXL) expression quantity or locations and cancers survival, but the results were far from conclusive. Therefore, we proceeded a meta-analysis on PODXL in various human cancers to find its prognostic value and followed confirmation using the TCGA datasets.

Methods: We performed a systematic search, and 18 citations, including 5705 patients were pooled in meta-analysis. Read More

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http://dx.doi.org/10.1186/s12885-020-07108-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331259PMC

Physical activity, health-related quality of life, and adjuvant endocrine therapy-related symptoms in women with hormone receptor-positive breast cancer.

Cancer 2020 Jul 2. Epub 2020 Jul 2.

Department of Oncology, Georgetown University, Washington, DC.

Background: Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET).

Methods: Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related QOL, AET-related symptoms, and levels of PA using validated measures. A Wald chi-square test and an analysis of variance were used to assess associations with PA and independent variables. Read More

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http://dx.doi.org/10.1002/cncr.33054DOI Listing

Integrating serine with tumour initiation.

Nat Rev Cancer 2020 Jul 1. Epub 2020 Jul 1.

Nature Reviews Cancer, .

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http://dx.doi.org/10.1038/s41568-020-0287-5DOI Listing

Impact of breath-hold level on positional error aligned by stent/Lipiodol in Hepatobiliary radiotherapy with breath-hold respiratory control.

BMC Cancer 2020 Jul 1;20(1):613. Epub 2020 Jul 1.

Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan South Rd, Taipei, 10002, Taiwan.

Background: Respiratory motion management with breath hold for patients with hepatobiliary cancers remain a challenge in the precise positioning for radiotherapy. We compared different image-guided alignment markers for estimating positional errors, and investigated the factors associated with positional errors under breath-hold control.

Methods: Spirometric motion management system (SDX) for breath holds was used in 44 patients with hepatobiliary tumor. Read More

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http://dx.doi.org/10.1186/s12885-020-07082-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328270PMC

Impact of the faecal immunochemical test on colorectal cancer survival.

BMC Cancer 2020 Jul 1;20(1):616. Epub 2020 Jul 1.

BIOEF: the Basque Foundation for Health Innovation and Research, Department of Gastroenterology, Biodonostia Institute, Avda Paseo Beguiristain s/n 20014, San Sebastián, Spain.

Background: There is already evidence that the faecal immunochemical test (FIT) is a useful tool for the diagnosis of colorectal cancer (CRC) that helps to identify symptomatic patients requiring early colonoscopy. Although the recommendation to use FIT is widely accepted, there are no data concerning whether this strategy improves patient survival.The objective was to assess whether the survival is higher if CRC patients have been first diagnosed by FIT (as compared with the rest of patients with CRC). Read More

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http://dx.doi.org/10.1186/s12885-020-07074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328266PMC

Postoperative adjuvant treatment strategy for hepatocellular carcinoma with microvascular invasion: a non-randomized interventional clinical study.

BMC Cancer 2020 Jul 1;20(1):614. Epub 2020 Jul 1.

Department of Hepatobiliary Surgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli Area, Chaoyang District, Beijing, 100021, China.

Background: Microvascular invasion (MVI) is considered to be one of the important prognostic factors that affect postoperative recurrence in patients with hepatocellular carcinoma (HCC) with variable results across their treatment options. This study was carried out to investigate efficacy of postoperative adjuvant RT in HCC patients with MVI.

Methods: This was single center, prospective study carried out in HCC patients with MVI, aged 35-72 years. Read More

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http://dx.doi.org/10.1186/s12885-020-07087-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329435PMC

Sterile, abscess-like cerebral lesion during trastuzumab therapy after HER2 status switch in a triple negative breast cancer patient: a case report and literature review.

BMC Cancer 2020 Jul 1;20(1):615. Epub 2020 Jul 1.

3rd Department of Internal Medicine, Semmelweis University, 4 Kútvölgyi street, Budapest, Pest, 1125, Hungary.

Background: Breast cancer is a global health problem - it is the most common malignancy among women. Triple negative breast cancers (TNBC) account for 10-20% of female breast cancer. Most TNBC cases confer poor prognosis. Read More

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http://dx.doi.org/10.1186/s12885-020-07114-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329406PMC

Sparing the hippocampus and the hypothalamic- pituitary region during whole brain radiotherapy: a volumetric modulated arc therapy planning study.

BMC Cancer 2020 Jun 30;20(1):610. Epub 2020 Jun 30.

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Background: Feasibility testing of a simultaneous sparing approach of hippocampus, hypothalamus and pituitary gland in patients undergoing whole-brain radiotherapy (WBRT) with and without a concomitant boost to metastatic sites.

Introduction: Cognitive impairment and hormonal dysfunction are common side effects of cranial radiotherapy. A reduced dose application to the patho-physiologically involved functional brain areas, i. Read More

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http://dx.doi.org/10.1186/s12885-020-07091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325372PMC

Analytical evaluation of the clonoSEQ Assay for establishing measurable (minimal) residual disease in acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma.

BMC Cancer 2020 Jun 30;20(1):612. Epub 2020 Jun 30.

Research and Development, Adaptive Biotechnologies Corporation, 1551 Eastlake Ave. E, Suite 200, Seattle, WA, 98102, USA.

Background: The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearrangements and IgH-BCL1/2 translocations in malignant B cells. Here, we describe studies to validate the analytical performance of the assay using patient samples and cell lines.

Methods: Sensitivity and specificity were established by defining the limit of detection (LoD), limit of quantitation (LoQ) and limit of blank (LoB) in genomic DNA (gDNA) from 66 patients with multiple myeloma (MM), acute lymphoblastic leukemia (ALL), or chronic lymphocytic leukemia (CLL), and three cell lines. Read More

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http://dx.doi.org/10.1186/s12885-020-07077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325652PMC

Cardio-toxicity among patients with sarcoma: a cardio-oncology registry.

BMC Cancer 2020 Jun 30;20(1):609. Epub 2020 Jun 30.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the impact on patients with sarcoma is limited, even though they are exposed to higher ANT doses. The commonly used term for cardio-toxicity is cancer therapeutics related cardiac dysfunction (CTRCD), defined as a left ventricular ejection fraction (LVEF) reduction of > 10%, to a value below 53%. Read More

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http://dx.doi.org/10.1186/s12885-020-07104-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325299PMC

Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study.

BMC Cancer 2020 Jun 30;20(1):611. Epub 2020 Jun 30.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.

Background: To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).

Method: One hundred four participants were enrolled in this retrospective study. Each participant performed preoperative Gd-EOB-DTPA-enhanced MR scanning. Read More

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http://dx.doi.org/10.1186/s12885-020-07094-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325565PMC