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    Course and predictors of post-traumatic stress disorder in a cohort of psychologically distressed patients with cancer: A 4-year follow-up study.
    Cancer 2017 Nov 20. Epub 2017 Nov 20.
    Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts.
    Background: Scant evidence exists on the long-term course of cancer-related post-traumatic stress disorder (PTSD). This is among the few studies worldwide, and the first in the South-East Asian region, to prospectively evaluate PTSD in patients with cancer using gold-standard clinical interviews. The objective of the study was to assess the course and predictors of PTSD in adult patients with cancer in a South-East Asian population. Read More

    Cost-effectiveness analysis of the introduction of S-1 therapy for first-line metastatic breast cancer treatment in Japan: results from the randomized phase III SELECT BC trial.
    BMC Cancer 2017 Nov 17;17(1):773. Epub 2017 Nov 17.
    Division of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
    Background: This study evaluated the cost-effectiveness of replacing standard intravenous therapy (taxane) with oral S-1 therapy for first-line metastatic breast cancer treatment.

    Methods: This cost-effectiveness analysis was based on data from a randomized phase III trial (SELECT BC). As cost-effectiveness was a secondary endpoint of the SELECT BC trial, some of the randomized patients participated in an EQ-5D survey (N = 391) and health economic survey (N = 146). Read More

    Process quality of decision-making in multidisciplinary cancer team meetings: a structured observational study.
    BMC Cancer 2017 Nov 17;17(1):772. Epub 2017 Nov 17.
    Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
    Background: The quality of decision-making in multidisciplinary team meetings (MDTMs) depends on the quality of information presented and the quality of team processes. Few studies have examined these factors using a standardized approach. The aim of this study was to objectively document the processes involved in decision-making in MDTMs, document the outcomes in terms of whether a treatment recommendation was given (none vs. Read More

    Cytoreductive surgery and Hyperthermic intra-operative peritoneal chemotherapy with Cisplatin for gastric peritoneal Carcinomatosis Monocentric phase-2 nonrandomized prospective clinical trial.
    BMC Cancer 2017 Nov 17;17(1):771. Epub 2017 Nov 17.
    Department of Digestive Oncology, University Hospitals KU Leuven, Leuven, Belgium.
    Background: Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking.

    Methods: Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%). Read More

    Sexual functioning among young adult cancer patients: A 2-year longitudinal study.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California Los Angeles, Los Angeles, California.
    Background: Cancer-related sexual dysfunction has been reported among adolescents and young adults (AYAs); however, its prevalence over time has not been examined. This longitudinal study investigated sexual dysfunction in AYAs over the course of 2 years after the initial diagnosis.

    Methods: Young adult patients (18-39 years old) completed the Medical Outcomes Study Sexual Functioning Scale within the first 4 months of their diagnosis (n = 123) and again 6 (n = 107) and 24 months later (n = 95). Read More

    Impact of chronic hepatitis C virus infection on the survival of patients with oropharyngeal cancer.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Although an association between hepatitis C virus (HCV) infection and oropharyngeal cancers (OPCs) has been reported, to the authors' knowledge the clinical significance of this epidemiological finding remains unknown. Therefore, the authors analyzed the oncologic outcomes of HCV-infected patients with OPCs.

    Methods: In this retrospective cohort study, all patients with OPCs who were seen at The University of Texas MD Anderson Cancer Center between January 2004 and December 2015 were reviewed. Read More

    Hospital quality, patient risk, and Medicare expenditures for cancer surgery.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Department of Surgery, University of Michigan, Ann Arbor, Michigan.
    Background: Surgical resection is a cornerstone of curative-intent therapy for patients with solid organ malignancies. With increasing attention paid to the costs of surgical care, there is a new focus on variations in the costs of cancer surgery. This study evaluated the potential interactive effect of hospital quality and patient risk on expenditures for cancer resections. Read More

    Pathfinders in oncology from the beginning of the 19th century to the inauguration of the first cancer hospital in the United States.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Pathology Consultants, Westlake Village, California.
    The fields of medicine and oncology made substantial progress between 1800 and 1885. The first half of this period was dominated by the spectacular progress in physiology, cytology, histology, histopathology, and diagnostic microscopy. In the second half of the period, advancements in surgical techniques, anesthesia, asepsis, and laboratory medicine, including bacteriology, chemistry, and biochemistry, led to the development of medical specialties, including surgical pathology and surgical oncology. Read More

    Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    Background: Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be sporadic or inherited because of germline mutations associated with von Hippel-Lindau disease (VHL) or multiple endocrine neoplasia type 1 (MEN1). The clinical behavior of NFPanNETs is difficult to predict, even in tumors of the same stage and grade. The authors analyzed genotype-specific patterns of transcriptional messenger RNA (mRNA) levels of NFPanNETs to understand the molecular features that determine PanNET phenotype. Read More

    A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children.
    Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, California.
    Background: Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) (ages 15-21 years).

    Methods: This prospective, observational cohort study was conducted at a single academic children's hospital. Read More

    Sphingolipid metabolism in cancer signalling and therapy.
    Nat Rev Cancer 2017 Nov 17. Epub 2017 Nov 17.
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA.
    Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-phosphate (S1P), have opposing roles in regulating cancer cell death and survival, respectively, and there have been exciting developments in understanding how sphingolipid metabolism and signalling regulate these processes in response to anticancer therapy. Recent studies have provided mechanistic details of the roles of sphingolipids and their downstream targets in the regulation of tumour growth and response to chemotherapy, radiotherapy and/or immunotherapy using innovative molecular, genetic and pharmacological tools to target sphingolipid signalling nodes in cancer cells. For example, structure-function-based studies have provided innovative opportunities to develop mechanism-based anticancer therapeutic strategies to restore anti-proliferative ceramide signalling and/or inhibit pro-survival S1P-S1P receptor (S1PR) signalling. Read More

    Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study.
    BMC Cancer 2017 Nov 16;17(1):769. Epub 2017 Nov 16.
    Department of Pathology, Kanagawa Cancer Center, 2-3-2, Nakao, Asahi-Ku, Yokohama, Kanagawa, 241-8515, Japan.
    Background: The worldwide incidence of neuroendocrine tumors (NETs) has increased remarkably, with the hindgut being the second most common site for such tumors. However, the mechanisms underlying progression and metastasis of hindgut NETs are unclear. A retrospective study was conducted to elucidate these mechanisms. Read More

    Renal failure during chemotherapy: renal biopsy for assessing subacute nephrotoxicity of pemetrexed.
    BMC Cancer 2017 Nov 16;17(1):770. Epub 2017 Nov 16.
    Pitié Salpêtrière Hospital, 75013, Paris, France.
    Background: Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Acute renal toxicity of pemetrexed has been recently described with polychemotherapy, in which the individual responsibility of each drug is difficult to establish. Only one recent report documents renal involvement in long-term exposed patients. Read More

    DETECT I & DETECT II: a study protocol for a prospective multicentre observational study to validate the UroMark assay for the detection of bladder cancer from urinary cells.
    BMC Cancer 2017 Nov 15;17(1):767. Epub 2017 Nov 15.
    Division of Surgery and Interventional Science, University College London, 74 Huntley Street, London, WC1E 6AU, UK.
    Background: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. Read More

    In response to Fogarty et al. and why adjuvant whole brain radiotherapy is not recommended routinely.
    BMC Cancer 2017 Nov 15;17(1):768. Epub 2017 Nov 15.
    Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia.
    The routine use of adjuvant whole brain radiotherapy (AWBRT) after surgery or stereotactic radiosurgery is now discouraged by a number of international expert panels. Three decades of randomised studies have shown that, although AWBRT improves radiological measures of intracranial disease control, the clinical benefit is unclear and it is also associated with inferior quality of life and neurocognitive function. The number of patients with melanoma in these trials was low, but data suggesting that treatment-related side effects should vary according to histology of the primary malignancy are lacking. Read More

    Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.
    BMC Cancer 2017 Nov 15;17(1):766. Epub 2017 Nov 15.
    School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
    Background: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression.

    Methods: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized. Read More

    Adherence to treatment guidelines and survival for older patients with stage II or III colon cancer in Texas from 2001 through 2011.
    Cancer 2017 Nov 15. Epub 2017 Nov 15.
    Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Treatment guidelines for colon cancer recommend colectomy with lymphadenectomy of at least 12 lymph nodes for patients with stage I to stage III disease as surgery adherence (SA) and adjuvant chemotherapy for individuals with stage III disease. Herein, the authors evaluated adherence to these guidelines among older patients in Texas with colon cancer and the associated survival outcomes.

    Methods: Using Texas Cancer Registry data linked with Medicare data, the authors included patients with AJCC stage II and III colon cancer who were aged ≥66 years and diagnosed between 2001 and 2011. Read More

    Analysis of factors influencing molecular testing at diagnostic of colorectal cancer.
    BMC Cancer 2017 Nov 14;17(1):765. Epub 2017 Nov 14.
    Department of Gastroenterology, Poitiers University Hospital, 2 rue de la Milétrie, 86000, Poitiers Cedex, France.
    Background: The aim of the study was to evaluate the current rate of molecular testing prescription (KRAS codons 12/13, BRAF and microsatellite instability (MSI)) in newly diagnosed colorectal cancer (CRC) patients and to determine which factors influence testing.

    Methods: All incident CRC cases in 2010 were identified in the Poitou-Charentes General Cancer Registry. The exhaustive molecular testing performed was accessed in the French molecular genetics platform. Read More

    Preoperative T staging using CT colonography with multiplanar reconstruction for very low rectal cancer.
    BMC Cancer 2017 Nov 14;17(1):764. Epub 2017 Nov 14.
    Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 1040045, Japan.
    Background: Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy. The aim of this study was to evaluate the accuracy of preoperative T staging using CT colonography (CTC) with multiplanar reconstruction (MPR), in which with the newest workstation the images can be analyzed with a slice thickness of 0.5 mm. Read More

    Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials.
    BMC Cancer 2017 Nov 14;17(1):763. Epub 2017 Nov 14.
    School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor, Malaysia.
    Background: Beneficial effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) against recurrent colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Uncertainty remains about the appropriate dose of aspirin for adenoma prevention. The persistence of the protective effect of NSAIDs against recurrent adenomas after treatment cessation is yet to be established. Read More

    Perioperative blood transfusion does not affect recurrence-free and overall survivals after curative resection for intrahepatic cholangiocarcinoma: a propensity score matching analysis.
    BMC Cancer 2017 Nov 14;17(1):762. Epub 2017 Nov 14.
    Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, China.
    Background: Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined.

    Methods: Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We conducted Cox regression and variable selection logistic regression analyses to identify confounding factors of PBT. Read More

    Meta-analysis comparing laparoscopic versus open resection for gastric gastrointestinal stromal tumors larger than 5 cm.
    BMC Cancer 2017 Nov 13;17(1):760. Epub 2017 Nov 13.
    Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, 710032, Xi'an, Shaanxi, China.
    Background: Data on the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm are limited. Therefore, the aim of this meta-analysis was to compared laparoscopic and open resection for gastric GISTs larger than 5 cm.

    Methods: We perform a literature search on PubMed, the Cochrane Library, and Embase. Read More

    Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk.
    BMC Cancer 2017 Nov 13;17(1):757. Epub 2017 Nov 13.
    Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Via Santena 7, Turin, Italy.
    Background: Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. Read More

    Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma.
    BMC Cancer 2017 Nov 13;17(1):759. Epub 2017 Nov 13.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Neuroendocrine prostate cancer (NEPC) may be rising in prevalence as patients with advanced prostate cancer potentially develop resistance to contemporary anti-androgen treatment through a neuroendocrine phenotype. While prior studies comparing NEPC and prostatic adenocarcinoma have identified important candidates for targeted therapy, most have relied on few NEPC patients due to disease rarity, resulting in thousands of differentially expressed genes collectively and offering an opportunity for meta-analysis. Moreover, past studies have focused on prototypical NEPC samples with classic immunohistochemistry profiles, whereas there is increasing recognition of atypical phenotypes. Read More

    Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer.
    BMC Cancer 2017 Nov 13;17(1):754. Epub 2017 Nov 13.
    Colorectal Tumor Nucleus of the Pelvic Surgery Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
    Background: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described.

    Methods: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas. Read More

    The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females.
    BMC Cancer 2017 Nov 13;17(1):758. Epub 2017 Nov 13.
    , Institute of Molecular Biology and Medicine, 3 Togolok Moldo Str, 720040, Bishkek, Kyrgyzstan.
    Background: The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgyz women.

    Methods: This was a case-control study of 219 women of Kyrgyz origin with morphologically verified BC (N = 117) and 102 controls, age-matched with BC cases. Read More

    Association between gene expression profile of the primary tumor and chemotherapy response of metastatic breast cancer.
    BMC Cancer 2017 Nov 13;17(1):755. Epub 2017 Nov 13.
    Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, Netherlands.
    Background: To better predict the likelihood of response to chemotherapy, we have conducted a study comparing the gene expression patterns of primary tumours with their corresponding response to systemic chemotherapy in the metastatic setting.

    Methods: mRNA expression profiles of breast carcinomas of patients that later developed distant metastases were analyzed using supervised and non-supervised classification techniques to identify predictors of response to chemotherapy. The top differentially expressed genes between the responders and non-responders were identified and further explored. Read More

    CAISMOV24, a new human low-grade serous ovarian carcinoma cell line.
    BMC Cancer 2017 Nov 13;17(1):756. Epub 2017 Nov 13.
    Faculdade de Ciências Médicas, University of Campinas, Campinas, SP, Brazil.
    Background: The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma.

    Methods: The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. Read More

    Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.
    BMC Cancer 2017 Nov 13;17(1):761. Epub 2017 Nov 13.
    Department of Bioinformatics & Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
    Background: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. Read More

    Diagnostic challenges and problem cases in salivary gland cytology: A 20-year experience.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    Division of Cytopathology, Pathology Department, The Johns Hopkins Hospital, Baltimore, Maryland.
    Background: Fine-needle aspiration (FNA) is routinely performed to evaluate salivary gland lesions, and provides valuable information regarding the cytomorphologic features of the lesions. Occasionally, there are overlaps between benign and malignant conditions due to heterogeneity of the cell types, metaplastic changes, and sampling issues. Herein, the authors present a retrospective study of diagnostic pitfalls in salivary gland cytology and the simulating conditions. Read More

    Biomarkers for immune checkpoint inhibitors: The importance of tumor topography and the challenges to cytopathology.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
    The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. Unfortunately, these responses are difficult to predict, so the goal of the right drug for the right patient at the right time remains elusive. Read More

    Validity and usefulness of a single-item measure of patient-reported bother from side effects of cancer therapy.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Background: The improving efficacy of cancer treatment has resulted in an increasing array of treatment-related symptoms and associated burdens imposed on individuals undergoing aggressive treatment of their disease. Often, clinical trials compare therapies that have different types, and severities, of adverse effects. Whether rated by clinicians or patients themselves, it can be difficult to know which side effect profile is more disruptive or bothersome to patients. Read More

    Optimizing active surveillance strategies to balance the competing goals of early detection of grade progression and minimizing harm from biopsies.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    University of Michigan, Ann Arbor, Michigan.
    Background: Active surveillance (AS) for prostate cancer includes follow-up with serial prostate biopsies. The optimal biopsy frequency during follow-up has not been determined. The goal of this investigation was to use longitudinal AS biopsy data to assess whether the frequency of biopsy could be reduced without substantially prolonging the time to the detection of disease with a Gleason score ≥ 7. Read More

    Efficacy of a community-based participatory and multilevel intervention to enhance hepatitis B virus screening and vaccination in underserved Korean Americans.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    Department of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: The primary objective of the current study was to evaluate the efficacy of a community-based participatory intervention program in improving hepatitis B virus (HBV) screening and vaccination among Korean Americans who were not previously screened.

    Methods: A cluster randomized trial involving 32 Korean church-based community organizations (1834 participants) was conducted. Sixteen churches were randomly assigned to an HBV screening and vaccination multicomponent intervention condition (972 participants) and 16 were assigned to a general cancer education control condition (862 participants). Read More

    Gross total resection and adjuvant radiotherapy most significant predictors of improved survival in patients with atypical meningioma.
    Cancer 2017 Nov 13. Epub 2017 Nov 13.
    Department of Radiation Oncology, Northwestern Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.
    Background: Atypical and malignant meningiomas are far less common than benign meningiomas. As aggressive lesions, they are prone to local recurrence and may lead to decreased survival. Although malignant meningiomas typically are treated with maximal surgical resection and adjuvant radiotherapy (RT), to the authors' knowledge the optimal treatment for atypical lesions remains to be defined. Read More

    Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors.
    BMC Cancer 2017 Nov 10;17(1):751. Epub 2017 Nov 10.
    Research Centre, Sainte-Justine University Health Center, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada.
    Background: While cure rates for childhood acute lymphoblastic leukemia (cALL) now exceed 80%, over 60% of survivors will face treatment-related long-term sequelae, including cardiometabolic complications such as obesity, insulin resistance, dyslipidemia and hypertension. Although genetic susceptibility contributes to the development of these problems, there are very few studies that have so far addressed this issue in a cALL survivorship context.

    Methods: In this study, we aimed at evaluating the associations between common and rare genetic variants and long-term cardiometabolic complications in survivors of cALL. Read More

    TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP.
    BMC Cancer 2017 Nov 10;17(1):743. Epub 2017 Nov 10.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
    Background: TP53 Arg72Pro (SNP rs1042522) is associated with risk of non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL. However, the relationship between this SNP and prognosis of DLBCL in Asians is unknown. Read More

    The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer.
    BMC Cancer 2017 Nov 10;17(1):744. Epub 2017 Nov 10.
    Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, People's Republic of China.
    Background: Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there is controversy concerning what is the best predictor of prognosis in CRC.

    Methods: A cohort of 1744 CRC patients in our institution was analyzed retrospectively. Read More

    Feasibility of structured endurance training and Mediterranean diet in BRCA1 and BRCA2 mutation carriers - an interventional randomized controlled multicenter trial (LIBRE-1).
    BMC Cancer 2017 Nov 10;17(1):752. Epub 2017 Nov 10.
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
    Background: Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors. Though, randomized trials investigating the impact of lifestyle interventions on cancer prevention and prognosis in BRCA carriers are still missing.

    Methods: We implemented a multicenter, prospective randomized controlled trial in BRCA1/2 patients, comparing a lifestyle intervention group (IG) with a control group (CG) with the primary aim to prove feasibility. Read More

    Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature.
    BMC Cancer 2017 Nov 10;17(1):746. Epub 2017 Nov 10.
    Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
    Background: Small cell carcinoma of the urinary bladder (SCCB) is a relatively rare malignant bladder tumor, and few reports have investigated the microvasculature of SCCB imaged using contrast-enhanced ultrasound (CEUS).

    Case Presentation: A 63-year-old female was admitted to our hospital after experiencing painless gross hematuria for one week. The gray-scale ultrasound (US) demonstrated a 4. Read More

    miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer.
    BMC Cancer 2017 Nov 10;17(1):745. Epub 2017 Nov 10.
    Laboratory of Department of Surgery, First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou, Guangdong, 510080, People's Republic of China.
    Background: Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigating the critical regulatory microRNAs (miRNAs) of ETV1 may be beneficial for TNBC targeted therapy. Read More

    MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1.
    BMC Cancer 2017 Nov 10;17(1):750. Epub 2017 Nov 10.
    The University of Texas Health Science Center at San Antonio, Children's Cancer Research Institute, 7703 Floyd Curl Drive, San Antonio, TX, 78229-390, USA.
    Background: Melanoma is the most lethal type of skin cancer. Since chemoresistance is a significant barrier, identification of regulators affecting chemosensitivity is necessary in order to create new forms of intervention. Prohibitin 1 (PHB1) can act as anti-apoptotic or tumor suppressor molecule, depending on its subcellular localization. Read More

    Safety and efficacy of abiraterone acetate in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: an Italian multicenter "real life" study.
    BMC Cancer 2017 Nov 10;17(1):753. Epub 2017 Nov 10.
    Department of Urology, ASL Abruzzo2, Via dei Vestini, Chieti, Italy.
    Background: To evaluate the safety and efficacy of abiraterone acetate (AA) in the "real life" clinical practice for men with chemotherapy-naïve metastatic castration-resistant prostate.

    Methods: A consecutive series of patients with mCRPC in 9 Italian tertiary centres treated with AA was collected. Demographics, clinical parameters, treatment outcomes and toxicity were recorded. Read More

    YRNA expression predicts survival in bladder cancer patients.
    BMC Cancer 2017 Nov 10;17(1):749. Epub 2017 Nov 10.
    Department of Urology, University Hospital Bonn, Bonn, Germany.
    Background: Non-coding RNAs play an important role in human carcinogenesis. YRNAs (Ro-associated Y), a novel class of non-coding RNAs, have been identified as biomarker in various malignancies, but remain to be studied in urinary bladder cancer (BCA) patients.

    Methods: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival BCA (urothelial carcinoma, n = 88) and normal urothelial bladder (n = 30) tissues using quantitative real-time PCR. Read More

    Thoracoscopic and hand assisted laparoscopic esophagectomy with radical lymph node dissection for esophageal squamous cell carcinoma in the left lateral decubitus position: a single center retrospective analysis of 654 patients.
    BMC Cancer 2017 Nov 10;17(1):748. Epub 2017 Nov 10.
    Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa University, 142-8666, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
    Background: The rates of thoracoscopic esophagectomy performed in the prone and left lateral decubitus positions are similar in Japan. We retrospectively reviewed short- and long-term outcomes of thoracoscopic esophagectomy for esophageal cancer performed in the left lateral decubitus position.

    Methods: Between 1996 and 2015, 654 patients with esophageal cancer underwent thoracoscopic esophagectomy in the left lateral decubitus position. Read More

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