9,744 results match your criteria Canadian journal of physiology and pharmacology[Journal]


Corrigendum: Endurance training alters basal erythrocyte MCT-1 contents and affects the lactate distribution between plasma and red blood cells in T2DM men following maximal exercise.

Can J Physiol Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

a Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.

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http://dx.doi.org/10.1139/cjpp-2019-0111DOI Listing

Promotion of whole blood rheology after vitamin C supplementation: Focus on red blood cells.

Can J Physiol Pharmacol 2019 Apr 13. Epub 2019 Apr 13.

Center of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia ;

Hemorheological properties represent significant contributors in the pathogenesis of cardiovascular diseases. As plasma vitamin C is inversely associated with blood viscosity in humans, we aimed to characterize the effect of vitamin C supplementation on hemorheology with an emphasis on erythrocyte functions. Twenty young healthy volunteers were ask to take vitamin C (1000 mg/day) for three weeks. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0735
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http://dx.doi.org/10.1139/cjpp-2018-0735DOI Listing
April 2019
1 Read

Angiotensin blockade attenuates diabetic nephropathy in hypogonadal adult male rats.

Can J Physiol Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Faculty of Medicine- Suez Canal University, Pharmacology , Pharmacology department- Faculty of Medicine- Suez Canal University , Ismailia, Egypt , +2-064 ;

This study examined the effect of the aromatase inhibitor letrozole (0.5 mg/kg) alone or in combination with the angiotensin-receptor blocker valsartan (30 mg/kg) against streptozocin-induced diabetic nephropathy (DN) in hypogonadal (HG) rats for 12 weeks. First, we tested the HG effect on hormone levels, inflammatory cytokines, and oxidative stress in non-diabetic (ND) and diabetic (D) rats. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0572DOI Listing
April 2019
1 Read

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.

Can J Physiol Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia, , Dubravska 9 , Bratislava, Slovakia , 841 0 ;

H2 has been clinically demonstrated to provide anti-oxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0067DOI Listing
April 2019
1 Read

SERUM IRISIN LEVEL IN MYOCARDIAL INFARCTION PATIENTS WITH OR WITHOUT HEART FAILURE.

Can J Physiol Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Assiut University Faculty of Medicine, 68797, Medical Physiology , Gamaa Street , Assiut, Egypt , 71516 ;

This study aimed to assess serum irisin level in myocardial infarction (MI) with or without heart failure (HF) and the possible relation between irisin and cardiac markers, TNF-α and lipid profile. 86 subjects were included (33 patients had MI, 33 patients had MI with HF and 20 controls). Body Mass Index (BMI), waist/hip ratio (WHR), systolic and diastolic blood pressure (SBP and DBP), heart rate, left ventricular ejection fraction (LVEF) were measured. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0736DOI Listing

Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H2O2)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells.

Can J Physiol Pharmacol 2019 Apr 2. Epub 2019 Apr 2.

Universite de Montreal Faculte de medecine, 12368, Montreal, Quebec, Canada ;

Increased generation of reactive oxygen species (ROS) is believed to play a key role in the pathophysiology of cardiovascular diseases. Excessive growth and proliferation of vascular smooth muscle cells (VSMC) have been suggested to be a major contributor to vascular dysfunction. A potential involvement of early growth response protein-1 (Egr-1), a zinc-finger transcription factor, in the development of vascular diseases has been suggested. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0061
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http://dx.doi.org/10.1139/cjpp-2019-0061DOI Listing
April 2019
4 Reads

Oxidative stress and metabolic parameters are differently affected by fructose when rats were kept sedentary or underwent swimming exercise.

Can J Physiol Pharmacol 2019 Apr 1. Epub 2019 Apr 1.

Federal University of Santa Maria, Santa Maria, Brazil ;

The current study evaluated whether fructose supplementation affects oxidative stress and metabolic parameters in the liver and gastrocnemius muscle of rats subjected to swimming exercise. Male adult Wistar rats received a fructose solution (10%) or water during 1 h before exercise and during the rest interval by the intragastric route. The swimming protocol consisted of 6 days, rats underwent 3 sessions of 17 min each, with a load of 5% of body weight, and 3 min of rest interval. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0620DOI Listing

Made in Canada.

Authors:

Can J Physiol Pharmacol 2019 Apr;97(4):iii

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http://dx.doi.org/10.1139/cjpp-2019-0095DOI Listing

Resveratrol prevents the development of high blood pressure in spontaneously hypertensive rats through the inhibition of enhanced expression of Giα proteins.

Can J Physiol Pharmacol 2019 Mar 29. Epub 2019 Mar 29.

University of Montreal , Department of Physiology , MONTREAL, Quebec, Canada , H3C 3J7 ;

Resveratrol (RV), a polyphenolic component of red wine, has been shown to attenuate high blood pressure (BP) in spontaneously hypertensive rats (SHR). We earlier showed a role of enhanced expression of Giα proteins in the pathogenesis of hypertension in SHR. In the present study, we investigated whether RV-induced decreased BP in SHR is attributed to its ability to inhibit the enhanced expression of Giα proteins and the upstream signaling molecules implicated in the overexpression of Giα proteins. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0040DOI Listing
March 2019
1.546 Impact Factor

Cardiovascular regulation - associations between exercise and head up tilt.

Can J Physiol Pharmacol 2019 Mar 27. Epub 2019 Mar 27.

German Sport University, Institute of Physiology and Anatomy, Cologne, Germany ;

It was hypothesized that faster cardiorespiratory kinetics during exercise are associated with higher orthostatic tolerance. Cardiorespiratory kinetics of fourteen healthy male subjects (30±4 y, 179±8 cm, 79±8 kg) were tested on a cycle ergometer during exercise with changing work rates (WR) of 30 W and 80 W. Pulmonary oxygen uptake (V'O2pulm) was measured breath-by-breath and heart rate (HR), mean arterial blood pressure (MAP) and total peripheral resistance (TPR) beat-to-beat. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0742DOI Listing
March 2019
1 Read

Apoptosis perturbations and expression of regulatory inflammatory factors in cisplatin-depleted rat livers under l-arginine protection.

Can J Physiol Pharmacol 2019 Mar 27:1-11. Epub 2019 Mar 27.

b Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Hepatic injury is one of the most common complications associated with cisplatin (CIS) use. Recently, liver protection lines are being discovered to stop the hepatic cell death due to inflammatory and apoptotic perturbations. l-arginine has protective effects in several models of liver injury. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0706DOI Listing

Role of catecholamines in the pathogenesis of diabetic cardiomyopathy.

Can J Physiol Pharmacol 2019 Mar 26. Epub 2019 Mar 26.

Asper Clinical Research Institute, St. Boniface Hospital, Office of Clinical Research , Cr3129-369 Tache Avenue , Winnipeg, Manitoba, Canada , R2H2A6 ;

Although the sympathetic nervous system (SNS) plays an important role in the regulation of cardiac function, the over-activation of the SNS under stressful conditions including diabetes has been shown to result in the excessive production of circulating catecholamines as well as increase in the myocardial concentration of catecholamines. In this brief review, we provide of some evidence to suggest that the oxidation products of catecholamines such as aminochrome and oxyradicals, lead to metabolic derangements, Ca2+- handling abnormalities, increase in the availability of intracellular free Ca2+ as well as activation of proteases and changes in myocardial gene expression. These alterations due to elevated levels of circulatory catecholamines are associated with oxidative stress, subcellular remodeling and the development of cardiac dysfunction in chronic diabetes. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0044DOI Listing

Alterations in myocardial connexin-43 and MMP-2 signaling in response to pregnancy and oxygen deprivation of Wistar rats: A pilot study.

Can J Physiol Pharmacol 2019 Mar 25. Epub 2019 Mar 25.

CEM SAS, Institute for Heart Research, Bratislava, Slovakia, Bratislava, Slovakia, Slovakia ;

Two important aspects of cardiac adaptive response to pregnancy have been studied in normal as well as hypoxic conditions: 1/ intercellular signaling mediated by myocardial connexin-43 (Cx43) that is crucial to synchronize heart function; 2/ extracellular signaling mediated by matrix metalloproteinase-2 (MMP-2) that is an early marker of extracellular matrix remodeling. Myocardial Cx43 distribution and functional capillary density were determined as well. Hypoxia was induced by exposure of rats to 10. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0740DOI Listing

Increase of NOX3 in heart failure of hereditary cardiomyopathy.

Can J Physiol Pharmacol 2019 Mar 21. Epub 2019 Mar 21.

University of Sherbrooke, 7321, Anatomy and Cell Biology, Faculty of Medicine, Sherbrooke, Quebec, Canada ;

During the development of heart failure in humans and animal models, an increase in reactive oxygen species (ROS) levels were observed. However, there is no information whether this increase of ROS is associated with an increase in the density of a specific isoform of NADPH oxidases (NOX1-5). The objective of this study was to verify whether the densities of NOXs 1-5 change during the development of heart failure. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0055DOI Listing

Extracelluar and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells.

Can J Physiol Pharmacol 2019 Mar 21. Epub 2019 Mar 21.

University of Sherbrooke, 7321, Anatomy and Cell Biology, Faculty of Medicine, Sherbrooke, Quebec, Canada ;

TNFα and its type 1 receptor (TNFR1) are implicated in several autoimmune diseases, including rheumatoid arthritis, and are associated with complications at the cardiovascular level. Using human cardiomyocytes, vascular smooth muscle, vascular endothelial and endocardial endothelial cells coupled to indirect immunofluorescence, our results showed the presence of TNFR1 at the levels of the plasma membrane (including the cytosol) and mostly at the level of the nuclear membranes (including the nucleoplasm). The distribution of the receptor is different between cell types; however, the density is significantly higher at the nuclear level in all four cell types. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0070DOI Listing

Developmental and sex differences in cardiac tolerance to ischemia/reperfusion injury: the role of mitochondria.

Can J Physiol Pharmacol 2019 Mar 20. Epub 2019 Mar 20.

Institute of Physiology , Academy of Sciences of the Czech Republic , Videnska 1083 , Prague 4, Czech Republic , 142 20 ;

Age and sex play essential role in the cardiac tolerance to ischemia/reperfusion (I/R) injury: cardiac resistance significantly decreases during postnatal maturation and female heart is more tolerant as compared with the male myocardium. It is widely accepted that mitochondrial dysfunction and particularly mitochondrial permeability transition pore (MPTP) opening plays a major role in determining the extent of cardiac I/R injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium as well as from adult male and female hearts. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0060DOI Listing
March 2019
4 Reads

Lack of influence of estrogen on myosin phosphorylation and posttetanic potentiation in muscles from young adult C57-Bl mice.

Can J Physiol Pharmacol 2019 Mar 19. Epub 2019 Mar 19.

Brock University , 500 Glenridge Ave , St. Catherines, Ontario, Canada , L2S 3A1 ;

Estrogen influences myosin phosphorylation and posttetanic potentiation (PTP) in murine fast muscle. We tested the hypothesis that this influence is mediated by estrogen effects on myosin light chain kinase (skMLCK) activity. To this end, EDL muscles from female wildtype and skMLCK deficient (skMLCK-/-) mice were grouped as: ovariectomized (OVX) with estrogen (E+), ovariectomized without estrogen (E-), sham surgery (Sham) and intact baseline (BL). Read More

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http://dx.doi.org/10.1139/cjpp-2018-0575DOI Listing

Evolocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, promotes angiogenesis in vitro.

Can J Physiol Pharmacol 2019 Mar 15:1-7. Epub 2019 Mar 15.

c Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

The proprotein convertases family is involved in several physiological processes such as cell growth, migration, and angiogenesis, and also in different pathological conditions. Evolocumab, an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9), has recently been approved for treatment of hypercholesterolemia. This study aimed to investigate the effect of evolocumab on angiogenesis in human umbilical vein endothelial cells (HUVECs). Read More

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http://dx.doi.org/10.1139/cjpp-2018-0542DOI Listing
March 2019
1 Read

Telomere length and age-dependent telomere attrition: the blood-and-muscle model .

Can J Physiol Pharmacol 2019 Apr 15;97(4):328-334. Epub 2019 Mar 15.

c Université de Lorraine, Inserm, DCAC, F-54000 Nancy, France.

Short telomere length (TL) is associated with atherosclerotic cardiovascular disease (ACVD) and other age-related diseases. It is unclear whether these associations originate from having inherently short TL or a faster TL attrition before or during disease development. We proposed the blood-and-muscle model to assess TL dynamics throughout life course. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0582DOI Listing
April 2019
5 Reads
1.546 Impact Factor

Treatment with hydrogen sulfide donor attenuates bone loss induced by modeled microgravity.

Can J Physiol Pharmacol 2019 Mar 14. Epub 2019 Mar 14.

Xi'an Jiaotong University, 12480, Department of Spine Surgery, Hong Hui Hospital, Xi'an, Shaanxi, China ;

The present study was undertaken to explore the therapeutic potential of hydrogen sulfide (H2S) against bone loss induced by modeled microgravity. Hind-limb suspension (HLS) and rotary wall vessel bioreactor (RWVB) were applied to model microgravity in vivo and in vitro, respectively. Treatment of rats with GYY4137 (a water soluble donor of H2S, 25mg/kg/day, i. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0521DOI Listing

SLMAP-3 is downregulated in human dilated ventricles and its overexpression promotes cardiomyocyte response to adrenergic stimuli by increasing intracellular calcium.

Can J Physiol Pharmacol 2019 Mar 11. Epub 2019 Mar 11.

King Faisal Specialist Hospital and Research Center, 37852, Department of Genetics, , P.O. Box 3354 , 11211 , Riyadh, Saudi Arabia , 11211.

Structural dilation of cardiomyocytes (CMs) imposes a decline in cardiac performance that precipitates cardiac failure and sudden death. Since membrane proteins are implicated in dilated cardiomyopathy and heart failure, we evaluated the expression of the sarcolemmal membrane-associated protein (SLMAP) in dilated cardiomyopathy and its effect on CM contraction. We found that all three SLMAP isoforms (SLMAP-1, -2, and -3) are expressed in CMs and are downregulated in human dilated ventricles. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0660DOI Listing
March 2019
1 Read

Vitamin D3 Supplementation Ameliorates Ovariectomy-Induced Cardiac Apoptotic and Structural Changes in Adult Albino Rats.

Can J Physiol Pharmacol 2019 Mar 11. Epub 2019 Mar 11.

Zagazig University Faculty of Human Medicine, 68865, pharmacology, Zagazig, Egypt ;

The effect of vitamin D on cardiac dysfunction after menopause is still under investigation. Therefore, we investigated the effect of vitamin D3 on cardiac apoptotic and structural changes in ovariectomized rats. Forty adult female albino rats were divided into 4 equal groups: sham rats, sham rats treated with vitamin D3, ovariectomized rats and ovariectomized rats treated with vitamin D3 (500 IU/kg/day/6 weeks, orally). Read More

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http://dx.doi.org/10.1139/cjpp-2018-0674DOI Listing

Thymosinβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?

Can J Physiol Pharmacol 2019 Mar 9. Epub 2019 Mar 9.

Henry Ford Hospital, 24016, Hypertension & Vascular Research , Suite E&R 7081 , 2799 West Grand Boulevardm , Detroit, Michigan, United States , 48202-2689.

The last 20 years witnessed the emergence of the thymosin 4 (T4)-N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) pathway as a new source of future therapeutic tools to treat cardiovascular and renal diseases. In this review article, we attempted to shed light on the numerous experimental findings pertaining to the many promising cardiovascular therapeutic avenues for the T4 and/or its N-terminal derivative, Ac-SDKP. Specifically, Ac-SDKP is endogenously produced from the 43-amino acid Tβ4 by two successive enzymes meprin α and prolyl oligopeptidase (POP). Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0570
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http://dx.doi.org/10.1139/cjpp-2018-0570DOI Listing
March 2019
2 Reads
1.546 Impact Factor

Could cardioprotective effect of ACE2 activator "diminazene aceturate" is more potent than ACE inhibitor "Enalapril" on acute myocardial infarction in rats?

Can J Physiol Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

Alexandria University Faculty of Medicine, Alexandria, Egypt ;

Myocardial infarction (MI) is a major cause of cardiac dysfunction. All components of the cardiac renin angiotensin system (RAS) are upregulated in MI. Angiotensin converting enzyme (ACE) and ACE2 are key enzymes involved in synthesis of components of RAS and provide a counter-regulatory mechanism within RAS. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0078DOI Listing

Effect of febuxostat on biochemical parameters of high fat diet-induced hyperlipidemia in rabbits.

Can J Physiol Pharmacol 2019 Mar 1. Epub 2019 Mar 1.

Mansoura University, 68779, Mansoura, Egypt ;

Objective-To test the potential anti-oxidant and anti-inflammatory effects of febuxostat and/or stopping high-fat diet on the biochemical parameters of high fat diet-induced hyperlipidemic rabbits. Background-Febuxostat, a highly potent xanthine oxidase inhibitor with antioxidant effect, inhibits elevated xanthine oxidase, leading to reduction of reactive oxygen species (ROS) and oxidative stress, the main causes of vascular inflammation in hyperlipidemia. Methods- Male New Zealand rabbits were distributed in three groups: normal control (NC) fed standard chow for 12 weeks; the other two groups fed high-fat diet (HFD) with 1% cholesterol for 8 weeks, and then shifted to standard chow for 4 weeks. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0731DOI Listing
March 2019
2 Reads

Introduction.

Can J Physiol Pharmacol 2019 Mar;97(3)

c University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1139/cjpp-2019-0012DOI Listing

Connecting Maternal, Fetal, and Newborn Physiology.

Authors:

Can J Physiol Pharmacol 2019 Mar;97(3):iii

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http://dx.doi.org/10.1139/cjpp-2019-0048DOI Listing

Contributions of Rho-kinase and AMP-related kinase (AMPK) Signaling Pathways to Endothelium-Derived Contracting Factors (EDCF)-mediated Responses in Diabetic Rat Aorta.

Can J Physiol Pharmacol 2019 Feb 20. Epub 2019 Feb 20.

Bezmialem Vakif Universitesi, 221265, Faculty of Pharmacy Department of Pharmacology , Bezmialem Vakif University Faculty of Pharmacy , Department of Pharmacology , Maltepe , Istanbul, Turkey , 34093 ;

Diabetes-induced endothelium damage leads to vascular dysfunction. The current study was designed to determine the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on endothelium-derived contracting factors (EDCF)-mediated responses with possible contributions of Rho-kinase and AMP-activated kinase (AMPK) signaling pathways. The effects of STZ-diabetes on vascular functions were examined in isolated thoracic aorta preparations of 30-week-old rats. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0698DOI Listing
February 2019

Short telomere subtelomeric hypomethylation is associated with telomere attrition in elderly diabetic patients .

Can J Physiol Pharmacol 2019 Apr 20;97(4):335-339. Epub 2019 Feb 20.

b Abe Medical Clinic, Oita, Japan.

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes (T2D) patients and diabetes-free controls (C). The methylation status was analyzed between MspI-TRF lengths and HpaII-TRF lengths by using methylation-sensitive and -insensitive restriction enzyme isoschizomers, MspI and HpaII, respectively. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0568DOI Listing

Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic stress-induced depression.

Can J Physiol Pharmacol 2019 Feb 16. Epub 2019 Feb 16.

VINCA Institute of Nuclear Sciences, 89101, Molecular biology and endocrinology, Beograd, Serbia ;

This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA and protein levels of tyrosine hydroxylase (TH), dopamine-b-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. CUMS caused a significant depletion of norepinephrine stores and protein levels of TH, DBH and NET, whereas the gene expression of PNMT was increased. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0612DOI Listing
February 2019

The impact of high intensity interval training and moderate intensity continious training regimes on cardiodynamic parameters in isolated heart of normotensive and hypertensive rats.

Can J Physiol Pharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia, Kragujevac, Serbia ;

This study was aimed to assess the impact of high intensity interval training (HIIT) vs. moderate intensity continious training (MIT) on cardiodynamic parameters in isolated rat heart. Wistar albino rats were randomly assigned to groups according to running protocol: sedentary control (CTRL), MIT, HIIT; spontaneous hypertensive sedentary control (SHR), spontaneous hypertensive rats (SHR) + MIT and SHR + HIIT. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0610DOI Listing
February 2019
3 Reads

Involvement of leukotriene pathway in the development of sevoflurane-induced pica in rats.

Can J Physiol Pharmacol 2019 Feb 7:1-4. Epub 2019 Feb 7.

b Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

We previously reported that sevoflurane-induced pica, kaolin ingestion behavior, in rats has the potential to reflect postoperative nausea and vomiting (PONV) in humans. It is well-known that corticosteroids, which inhibit both prostaglandin and leukotriene syntheses due to phospholipase A inhibition, are effective for reducing PONV; however, the precise mechanisms remain unclear. We investigated the involvement of the prostaglandin or leukotriene pathway in the development of sevoflurane-induced pica. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0494DOI Listing
February 2019

Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor.

Can J Physiol Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

University of Sherbrooke, 7321, Anatomy and Cell Biology, Faculty of Medicine, Sherbrooke, Quebec, Canada ;

Endocardial endothelial cells (EECs) form a monolayer lining the ventricular cavities. Studies from our laboratory and the literature have shown differences between EECs isolated from the right and left ventricles (EECRs and EECLs respectively). Angiotensin II (Ang II) was shown to induce apoptosis of different cell types mainly via AT1 receptor activation. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0592DOI Listing
February 2019

Relaxant Effect of Atorvastatin on Isolated Rat Gastric Fundus Strips: Implications for Ca2+ signalling mechanisms.

Can J Physiol Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Istanbul University, Faculty of Pharmacy, Pharmacology, Istanbul, Turkey ;

Statins are determined to have various pleiotropic effects apart from their lipid lowering properties. Herein, we investigated the direct effects of atorvastatin on gastric smooth muscle tone. Atorvastatin effectively relaxed isolated rat gastric fundus strips precontracted with acetylcholine, potassium chloride and serotonin. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0723DOI Listing
February 2019
2 Reads

Two different melatonin treatment regimens prevent an increase in kidney injury marker-1 induced by carbon tetrachloride in rat kidneys.

Can J Physiol Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Universitet u Nisu Medicinski Fakultet, 186001, Department of Biochemistry , ZoranaĐinđića 81 , Nis, Serbia , 18000 ;

Acute kidney injury (AKI) is a frequent disorder that can be mimicked by the application of different nephrotoxic agents, including carbon tetrachloride (CCl4), where kidney injury marker-1 (KIM-1) has been recognized as a highly specific marker. Melatonin represents one of the most powerful natural antioxidants which has numerous beneficial properties. We evaluated the nephroprotective potential of two melatonin-treatment (pre- and post-intoxication) regimens in a CCl4-induced AKI model based on the standard serum parameters, kidney tissue antioxidative capacity, KIM-1 levels, and kidney tissue morphological changes. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0641DOI Listing
February 2019
6 Reads

Protective effect of ghrelin against tilmicosin-induced left ventricular dysfunction in rats.

Authors:
Ebru Çetin

Can J Physiol Pharmacol 2019 Feb 6:1-6. Epub 2019 Feb 6.

Department of Physiology, Faculty of Veterinary Medicine, Erciyes University, 38039, Kayseri, Turkey.

This study was conducted to investigate the possible protective effects of ghrelin against tilmicosin-induced acute ventricular dysfunction in rats. Forty adult male Sprague Dawley rats were randomly divided into 4 equal groups: control, ghrelin, tilmicosin, and ghrelin + tilmicosin. The left ventricular structural and functional parameters together with cardiac biomarker levels were evaluated. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0511DOI Listing
February 2019

Src kinase controls signaling pathways in sensory neuron triggered by low-power infrared radiation.

Can J Physiol Pharmacol 2019 Feb 2:1-7. Epub 2019 Feb 2.

Laboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Nab. Makarova, 199034, Saint Petersburg, Russia.

Low-power (non-thermal) infrared (IR) radiation with the wavelength of 10.6 μm activates the Na,K-ATPase transducer function in sensory neurons, which is manifested in decrease of Na1.8 channel voltage sensitivity at the cellular membrane level and in inhibition of growth of chick embryo dorsal root ganglia neurites at the tissue level. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0602DOI Listing
February 2019
2 Reads

Liver mitochondrial respiratory plasticity and oxygen uptake evoked by cobalt chloride in rats with low and high resistance to extreme hypobaric hypoxia.

Can J Physiol Pharmacol 2019 Jan 25:1-8. Epub 2019 Jan 25.

d Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

High-altitude intolerance and consequently high-altitude sickness, is difficult to predict. Liver is an essential organ in glucose and lipid metabolism, and may play key role in the adaptation to high altitude. In response to extreme high altitude, mitochondrial respiration exhibits changes in substrate metabolism, mitochondrial electron transport chain activity, and respiratory coupling. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0642DOI Listing
January 2019
1 Read

Assessment and clinical relevance of the dynamic parameters of ventricular repolarization in patients with grade I left ventricular diastolic dysfunction.

Can J Physiol Pharmacol 2019 Jan 24. Epub 2019 Jan 24.

Instituto Cardiovascular Sâo Francisco de Assis, Belo Horizonte, Brazil ;

Imbalance in ventricular repolarization parameters are related to increased risk of severe arrhythmia and sudden cardiac death. There is limited research regarding markers to detect patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular diastolic dysfunction on repolarization parameters in asymptomatic patients. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0507DOI Listing
January 2019

Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.

Can J Physiol Pharmacol 2019 Jan 23:1-6. Epub 2019 Jan 23.

d Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

The apoptosis of bronchial and alveolar epithelial cells plays a key role in chronic obstructive pulmonary disease (COPD). The endoplasmic reticulum (ER) stress induced by cigarette smoke contributes to apoptosis. Previous studies demonstrated that melatonin prevented the development of COPD. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0529
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http://dx.doi.org/10.1139/cjpp-2018-0529DOI Listing
January 2019
10 Reads

The effect of cannabinoid receptor 1 blockade on adipokine and proinflammatory cytokine concentration in adipose and hepatic tissue in mice with nonalcoholic fatty liver disease.

Can J Physiol Pharmacol 2019 Feb 23;97(2):120-129. Epub 2019 Jan 23.

a Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.

In high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD), there is an increase in the endocannabinoid system activity, which significantly contributes to steatosis development. The aim of our study was to investigate the effects of cannabinoid receptor type 1 blockade on adipokine and proinflammatory cytokine content in adipose and hepatic tissue in mice with NAFLD. Male mice C57BL/6 were divided into a control group fed with a control diet for 20 weeks (C, n = 6) a group fed with a HFD for 20 weeks (HF, n = 6), a group fed with a control diet and treated with rimonabant after 18 weeks (R, n = 9), and a group fed with HFD and treated with rimonabant after 18 weeks (HFR, n = 10). Read More

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http://dx.doi.org/10.1139/cjpp-2018-0607DOI Listing
February 2019
9 Reads

Cyclooxygenase inhibitors for treating preterm labour: What is the molecular evidence? .

Can J Physiol Pharmacol 2019 Mar;97(3):222-231

a Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW Calgary, AB T2N 4N1, Canada.

Preterm birth (<37 weeks of gestation) significantly increases the risk of neonatal mortality and morbidity. As many as half of all preterm births occur following spontaneous preterm labour. Since in such cases there are no known reasons for the initiation of labour, treatment of preterm labour (tocolysis) has sought to stop labour contractions and delay delivery. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0380DOI Listing
March 2019
1 Read

Caffeine attenuates contraction-induced diminutions of the intracellular calcium transient in mouse lumbrical muscle ex vivo.

Can J Physiol Pharmacol 2019 Jan 19:1-7. Epub 2019 Jan 19.

b Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

The amount of calcium released from the sarcoplasmic reticulum in skeletal muscle rapidly declines during repeated twitch contractions. In this study, we test the hypothesis that caffeine can mitigate these contraction-induced declines in calcium release. Lumbrical muscles were isolated from male C57BL/6 mice and loaded with the calcium-sensitive indicator, AM-furaptra. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0658DOI Listing
January 2019

Prenatal determinants of childhood obesity: a review of risk factors .

Can J Physiol Pharmacol 2019 Mar 19;97(3):147-154. Epub 2019 Jan 19.

b Centre de recherche de Centre Hospitalier Universitaire de Sherbrooke (CRCHUS) and Department of Obstetrics and Gynecology, Université de Sherbrooke, Quebec, QC J1H 5N4, Canada.

Childhood obesity is a predictor of adult obesity and has its roots in the pre-pregnancy or pregnancy period. This review presents an overview of the prenatal risk factors for childhood obesity, which were categorized into 2 groups: biological risk factors (maternal pre-pregnancy body mass index, gestational weight gain, diabetes in pregnancy, and caesarean section), and environmental and behavioural risk factors (maternal smoking and exposure to obesogens, maternal dietary patterns, maternal intestinal microbiome and antibiotics exposure, and maternal psychosocial stress). Identifying modifiable predisposing prenatal factors for obesity will inform further development of inventions to prevent obesity over the life course, and future directions for research and intervention are discussed. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0403
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http://dx.doi.org/10.1139/cjpp-2018-0403DOI Listing
March 2019
6 Reads

Malnutrition and depression in pregnancy and associations with child behaviour and cognitive function: a review of recent evidence on unique and joint effects .

Can J Physiol Pharmacol 2019 Mar 9;97(3):158-173. Epub 2019 Jan 9.

a Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

Accumulating studies suggest that prenatal experiences can shape a child's neurodevelopment. Malnutrition and depression occur in pregnancy relatively often and may affect child neurodevelopment independently as well as synergistically. We aimed to provide an overview of recent studies that have examined malnutrition and (or) depression in pregnancy and associations with child behavioural problems and cognitive function. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0381
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http://dx.doi.org/10.1139/cjpp-2018-0381DOI Listing
March 2019
9 Reads

Comparative effects of nitric oxide dependent and independent vasodilation on impaired hindlimb revascularization in eNOS mice.

Can J Physiol Pharmacol 2019 Jan 9:1-9. Epub 2019 Jan 9.

a Unidad Monterrey, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apodaca, Nuevo León, México.

Ischemia due to vascular occlusion induces vasodilation as an initial response, followed by arteriogenesis or angiogenesis. Vasodilation through nitric oxide (NO) independent and dependent mechanisms may be sufficient to restore the altered neovascularization in pathological situations where the NO is altered. Using a posterior limb claudication model to evaluate ischemia-induced revascularization in eNOS mice, we compared the effects of sodium nitrite, a NO-dependent vasodilator, and prazocin, an alpha-adrenergic blocker and NO-independent vasodilator, on hindlimb revascularization. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0716
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http://dx.doi.org/10.1139/cjpp-2018-0716DOI Listing
January 2019
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Are the cardioprotective effects of the phytoestrogen resveratrol sex dependent?

Can J Physiol Pharmacol 2018 Dec 21. Epub 2018 Dec 21.

St. Boniface Hospital Research Centre , Insitute of Cardiovascular Sciences , R4011 - 351 Tache Avenue , Winnipeg, Manitoba, Canada , R2H 2A6 ;

Cardiovascular disease (CVD) is the number one cause of death in both men and women. Younger women have a lower risk for CVD, but their risk increases considerably after menopause when estrogen levels decrease. The cardiovascular protective properties of estrogen are mediated through decreasing vascular inflammation and progression of atherosclerosis, decreasing endothelial cell damage by preventing apoptosis and anti-hypertrophic mechanisms. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0544
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http://dx.doi.org/10.1139/cjpp-2018-0544DOI Listing
December 2018
5 Reads

Klotho protein inhibits HO-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways.

Can J Physiol Pharmacol 2018 Dec 21:1-7. Epub 2018 Dec 21.

a Department of Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou 121001, China.

Klotho protein secreted in the blood could act as a hormone to regulate various target organs and have a protective effect on the cardiovascular system. Numerous studies had shown that Klotho protein had antioxidative stress, anti-inflammatory, and antiapoptotic effects on vascular endothelial cells. The purpose of this study was to investigate the protective mechanism of Klotho protein on oxidative damage of vascular endothelial cells induced by HO. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0277DOI Listing
December 2018

Dietary flaxseed: what we know and don't know about its effects on cardiovascular disease.

Can J Physiol Pharmacol 2019 Feb 18;97(2):75-81. Epub 2018 Dec 18.

a Canadian Centre for Agri-food Research in Health and Medicine, Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada.

Flaxseed (Linum usitatissimum) is composed of a unique combination of bioactive components that appear to generate, through either an isolated or a synergistic action, a significant beneficial effect on the cardiovascular system. With a significant increase in the generation of data on the dietary impact of flaxseed on the cardiovascular system, a review of where we stand - what we know and what we still need to understand about these effects on the heart and the vasculature - was thought to be of value and the rationale for this paper. For example, although we now know how to deliver the bioactives most efficiently (oil versus ground seed versus whole seed), we do not know how different foods can influence that delivery. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0547DOI Listing
February 2019

Nandrolone administration abolishes hippocampal fEPSP-PS potentiation and passive avoidance learning of adolescent male rats.

Can J Physiol Pharmacol 2019 Feb 18;97(2):130-139. Epub 2018 Dec 18.

c Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Despite the chronic effects of nandrolone decanoate (ND), the acute effects of ND on passive avoidance learning (PAL) and memory and its mechanism have not been investigated. This research examines the acute effect of ND on PAL, CA1 synaptic plasticity, testosterone and corticosterone serum levels, and the role of androgenic receptors (ARs). Adolescent male rats were treated with ND, 30 min before training and retention and after training test. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0293DOI Listing
February 2019