261 results match your criteria Canadian journal of kidney health and disease[Journal]


Identifying Mobile Applications Aimed at Self-Management in People With Chronic Kidney Disease.

Can J Kidney Health Dis 2019 13;6:2054358119834283. Epub 2019 Mar 13.

Department of Medicine, Cumming School of Medicine, University of Calgary, AB, Canada.

Background: A growing number of mobile applications (apps) target people with chronic illness as the primary user. There is increasing evidence that digital technology can improve health outcomes for users but the sheer number of apps available is likely to overwhelm many potential users.

Objective: The purpose of this study was to systematically search for apps aimed at people with chronic kidney disease. Read More

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http://dx.doi.org/10.1177/2054358119834283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419251PMC
March 2019
2 Reads

Risk Factors for Unplanned Dialysis Initiation: A Systematic Review of the Literature.

Can J Kidney Health Dis 2019 13;6:2054358119831684. Epub 2019 Mar 13.

McMaster University, Hamilton, ON, Canada.

Background: Unplanned dialysis initiation is common in patients with chronic kidney disease (CKD).

Objective: To determine common definitions and patient risk factors for unplanned dialysis.

Design: Systematic review. Read More

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http://dx.doi.org/10.1177/2054358119831684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419254PMC
March 2019
2 Reads

Burden, Access, and Disparities in Kidney Disease.

Can J Kidney Health Dis 2019 12;6:2054358119836124. Epub 2019 Mar 12.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting more than 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1177/2054358119836124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415472PMC
March 2019
2 Reads

A Review of Cannabis in Chronic Kidney Disease Symptom Management.

Can J Kidney Health Dis 2019 22;6:2054358119828391. Epub 2019 Feb 22.

University of British Columbia, Vancouver, Canada.

Purpose Of Review: Physical and psychological symptom burden in patients with advanced chronic kidney disease (CKD) is significantly debilitating; yet, it is often inadequately treated. Legalization of cannabis in Canada may attract increasing interest from patients for its medical use in refractory symptom management, but its indications and long-term adverse health impacts are poorly established, creating a challenge for clinicians to support its use. In this review, we summarize key clinical studies and the level of evidence for nonsynthetic cannabinoids in the treatment of common symptoms encountered in advanced stages of CKD, including chronic pain, nausea and vomiting, anorexia, pruritus, and insomnia. Read More

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http://dx.doi.org/10.1177/2054358119828391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388458PMC
February 2019
3 Reads

Outcomes Following Macrolide Use in Kidney Transplant Recipients.

Can J Kidney Health Dis 2019 21;6:2054358119830706. Epub 2019 Feb 21.

Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, AB, Canada.

Background: Calcineurin inhibitors (CNI; cyclosporine, tacrolimus) are critical for kidney transplant immunosuppression, but have multiple potential drug interactions, such as with macrolide antibiotics. Macrolide antibiotics (clarithromycin, erythromycin, and azithromycin) are often used to treat atypical infections. Clarithromycin and erythromycin inhibit CNI metabolism and increase the risk of CNI nephrotoxicity, while azithromycin does not. Read More

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http://dx.doi.org/10.1177/2054358119830706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385328PMC
February 2019
1 Read

A Survey Study of Self-Rated Patients' Knowledge About AKI in a Post-Discharge AKI Clinic.

Can J Kidney Health Dis 2019 21;6:2054358119830700. Epub 2019 Feb 21.

Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky Medical Center, Lexington, KY, USA.

Background: Survivors of acute kidney injury (AKI) are at risk of adverse outcomes. Post-discharge nephrology care may improve patients' AKI knowledge and prevent post-AKI complications.

Objective: The purpose of this study was to examine patients' awareness about their AKI diagnosis and self-rated knowledge and severity of AKI before and after their first post-discharge AKI Clinic encounter. Read More

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http://dx.doi.org/10.1177/2054358119830700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385327PMC
February 2019
2 Reads

Variation of High-Sensitivity Troponin T Results in Patients Undergoing Continuous Renal Replacement Therapy.

Can J Kidney Health Dis 2019 15;6:2054358119828386. Epub 2019 Feb 15.

Division of Nephrology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, QC, Canada.

Background: Cardiac troponins are the preferred biomarker to diagnose myocardial injury. Complicating the interpretation of serial troponins in patients with end-stage renal disease, it has been shown that the hemodialysis procedure results in a small but significant decline in high-sensitivity cardiac troponins (hs-cTnT). This raises the possibility that continuous renal replacement therapy (CRRT) might similarly alter cardiac troponin levels and affect their interpretation when cardiac ischemia is being considered. Read More

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http://dx.doi.org/10.1177/2054358119828386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378428PMC
February 2019
2 Reads

Health Professional-Identified Barriers to Living Donor Kidney Transplantation: A Qualitative Study.

Can J Kidney Health Dis 2019 13;6:2054358119828389. Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

Background: Living donor kidney transplantation (LDKT) has several advantages over deceased donor kidney transplantation. Yet rates of living donation are declining in Canada and there exists significant interprovincial variability. Efforts to improve living donation tend to focus on the patient and barriers identified at their level, such as not knowing how to ask for a kidney or lack of education. Read More

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http://dx.doi.org/10.1177/2054358119828389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376531PMC
February 2019

Central Blood Pressure and Pulse Wave Velocity Changes Post Renal Denervation in Patients With Stages 3 and 4 Chronic Kidney Disease: The Regina RDN Study.

Can J Kidney Health Dis 2019 13;6:2054358119828388. Epub 2019 Feb 13.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Background: Central aortic blood pressures and arterial stiffness are better indicators of cardiovascular outcomes than brachial blood pressures. However, their response to renal denervation (RDN) in patients with Stage 3 and Stage 4 chronic kidney disease (CKD) has not yet been examined.

Objective: To evaluate the impact of RDN on central blood pressures (CBP), brachial (office and ambulatory) blood pressures, arterial stiffness, glomerular filtration rate (GFR), 24-hour urine protein, and selective cardiac parameters observed on echocardiograms. Read More

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http://dx.doi.org/10.1177/2054358119828388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376516PMC
February 2019

A Validation Study of Administrative Health Care Data to Detect Acute Kidney Injury in the Pediatric Intensive Care Unit.

Can J Kidney Health Dis 2019 10;6:2054358119827525. Epub 2019 Feb 10.

Department of Pediatrics, Division of Nephrology, Toronto Hospital for Sick Children, University of Toronto, ON, Canada.

Background: Large studies evaluating pediatric acute kidney injury (AKI) epidemiology and outcomes are lacking, partially due to underuse of large administrative health care data.

Objective: To assess the diagnostic accuracy of administrative health care data-defined AKI in children admitted to the pediatric intensive care unit (PICU).

Design: Retrospective cohort study utilizing chart and administrative data. Read More

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http://dx.doi.org/10.1177/2054358119827525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376545PMC
February 2019
1 Read

Single Questions for the Screening of Anxiety and Depression in Hemodialysis.

Can J Kidney Health Dis 2019 24;6:2054358118825441. Epub 2019 Jan 24.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Depression and anxiety are common and underrecognized in end-stage renal disease (ESRD), are associated with poor outcomes and reduced health-related quality of life, and are potentially treatable. Simple, accurate screening tools are needed.

Objective: We examined the operating characteristics of single questions for anxiety and depression from the Edmonton Symptom Assessment System (ESAS) in hemodialysis. Read More

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http://dx.doi.org/10.1177/2054358118825441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348566PMC
January 2019

Canadian Nephrologist Views Regarding Stroke and Systemic Embolism Prevention in Dialysis Patients With Nonvalvular Atrial Fibrillation: A Survey.

Can J Kidney Health Dis 2019 8;6:2054358118821945. Epub 2019 Jan 8.

Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Nonvalvular atrial fibrillation (NVAF) is an independent risk factor for ischemic stroke and is common in chronic kidney disease (CKD) and dialysis patients. The use of oral anticoagulation to prevent stroke and systemic embolism in the setting of kidney disease is controversial. Novel alternatives to vitamin K antagonists include left atrial appendage occlusion devices (LAAOD) and apixaban. Read More

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http://dx.doi.org/10.1177/2054358118821945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327328PMC
January 2019

Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease-1: Study Protocol for a Multicenter Clinical Trial.

Can J Kidney Health Dis 2018 5;5:2054358118813088. Epub 2018 Dec 5.

Division of Nephrology, Department of Medicine, Western University, London, ON, Canada.

Background: The progression to end-stage renal disease (ESRD) is the most important complication of chronic kidney disease (CKD). Patients with ESRD require dialysis or transplantation to survive, incur numerous complications, and have high mortality rates. Slowing the progression of CKD is an important goal. Read More

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http://dx.doi.org/10.1177/2054358118813088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299333PMC
December 2018
17 Reads

Determinants of Left Ventricular Characteristics Assessed by Cardiac Magnetic Resonance Imaging and Cardiovascular Biomarkers Related to Kidney Transplantation.

Can J Kidney Health Dis 2018 9;5:2054358118809974. Epub 2018 Nov 9.

Division of Endocrinology and Metabolism, St. Michael's Hospital, University of Toronto, ON, Canada.

Background: Cardiac magnetic resonance (CMR) imaging accurately and precisely measures left ventricular (LV) mass and function. Identifying mechanisms by which LV mass change and functional improvement occur in some end-stage kidney disease (ESKD) patients may help to appropriately target kidney transplant (KT) recipients for further investigation and intervention. The concentration of serum adiponectin, a cardiovascular biomarker, increases in cardiac failure, its production being enhanced by B-type natriuretic peptide (BNP), and both serum adiponectin and BNP concentrations decline posttransplantation. Read More

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http://dx.doi.org/10.1177/2054358118809974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236646PMC
November 2018
10 Reads

An Adjustable Dalteparin Sodium Dose Regimen for the Prevention of Clotting in the Extracorporeal Circuit in Hemodialysis: A Clinical Trial of Safety and Efficacy (the PARROT Study).

Can J Kidney Health Dis 2018 4;5:2054358118809104. Epub 2018 Nov 4.

Pfizer Essential Health, Pfizer Canada Inc, Kirkland, QC, Canada.

Background: Dalteparin sodium, a low-molecular-weight heparin, is indicated for prevention of clotting in the extracorporeal circuit during hemodialysis (HD). Product labeling recommends a fixed single-bolus dose of 5000 international units (IU) for HD sessions lasting up to 4 hours, but adjustable dosing may be beneficial in clinical practice.

Objective: The aim of the PARROT study was to investigate the safety and efficacy of an adjustable dose of dalteparin in patients with end-stage renal disease requiring 3 to 4 HD sessions per week. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118809104
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http://dx.doi.org/10.1177/2054358118809104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236648PMC
November 2018
2 Reads

Barriers to Education and Shared Decision Making in the Chronic Kidney Disease Population: A Narrative Review.

Can J Kidney Health Dis 2018 2;5:2054358118803322. Epub 2018 Nov 2.

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Purpose Of Review: Provision of education to inform decision making for renal replacement therapy (RRT) is a key component in the management of chronic kidney disease (CKD), yet patients report suboptimal satisfaction with the process of selecting a dialysis modality. Our purpose is to review the influencers of RRT decision making in the CKD population, which will better inform the process of shared decision making between clinicians and patients.

Sources Of Information: PubMed and Google Scholar. Read More

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http://dx.doi.org/10.1177/2054358118803322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236635PMC
November 2018

Perceived Significance of Engagement in Research Prioritization Among Chronic Kidney Disease Patients, Caregivers, and Health Care Professionals: A Qualitative Study.

Can J Kidney Health Dis 2018 19;5:2054358118807480. Epub 2018 Oct 19.

Institute of Health Policy, Management, and Evaluation, University of Toronto, ON, Canada.

Background: Patients and other stakeholders are increasingly engaging as partners in research, although how they perceive such experiences, particularly over the long term, is not well understood.

Objective: To characterize how participants from a nondialysis chronic kidney disease (CKD) research priority-setting project conducted 2 years previously perceived the significance of their involvement.

Design: Qualitative descriptive study with semi-structured, individual interviews. Read More

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http://dx.doi.org/10.1177/2054358118807480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196622PMC
October 2018
12 Reads

Comparing Five Comorbidity Indices to Predict Mortality in Chronic Kidney Disease: A Retrospective Cohort Study.

Can J Kidney Health Dis 2018 15;5:2054358118805418. Epub 2018 Oct 15.

Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Background: Several different indices summarize patient comorbidity using health care data. An accurate index can be used to describe the risk profile of patients, and as an adjustment factor in analyses. How well these indices perform in persons with chronic kidney disease (CKD) is not well known. Read More

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http://dx.doi.org/10.1177/2054358118805418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195002PMC
October 2018

Kidney Function, ACE-Inhibitor/Angiotensin Receptor Blocker Use, and Survival Following Hospitalization for Heart Failure: A Cohort Study.

Can J Kidney Health Dis 2018 15;5:2054358118804838. Epub 2018 Oct 15.

Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, AB, Canada.

Background: Angiotensin-converting enzyme inhibitors/angiotensin receptor blocker (ACE-I/ARB) improve outcomes in patients with heart failure and reduced left-ventricular (LV) systolic function. However, these medications can cause a rise in serum creatinine and their benefits in patients with HF accompanied by kidney disease are less certain.

Objective: To characterize associations between estimated glomerular filtration rate (eGFR), patterns of ACE-Is and ARBs use, and 1-year survival following hospitalization for heart failure (HF). Read More

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http://dx.doi.org/10.1177/2054358118804838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194922PMC
October 2018
25 Reads

Updated Canadian Expert Consensus on Assessing Risk of Disease Progression and Pharmacological Management of Autosomal Dominant Polycystic Kidney Disease.

Can J Kidney Health Dis 2018 12;5:2054358118801589. Epub 2018 Oct 12.

Division of Nephrology, Département de Médecine, Pharmacologie et Physiologie, Hôpital du Sacré-Cœur de Montréal, Université de Montréal, QC, Canada.

Purpose: The purpose of this article is to update the previously published consensus recommendations from March 2017 discussing the optimal management of adult patients with autosomal dominant polycystic kidney disease (ADPKD). This document focuses on recent developments in genetic testing, renal imaging, assessment of risk regarding disease progression, and pharmacological treatment options for ADPKD.

Sources Of Information: Published literature was searched in PubMed, the Cochrane Library, and Google Scholar to identify the latest evidence related to the treatment and management of ADPKD. Read More

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http://dx.doi.org/10.1177/2054358118801589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187423PMC
October 2018
1 Read

Educational Support Around Dialysis Modality Decision Making in Patients With Chronic Kidney Disease: Qualitative Study.

Can J Kidney Health Dis 2018 8;5:2054358118803323. Epub 2018 Oct 8.

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Background: Patients with chronic kidney disease (CKD) are asked to choose a renal replacement therapy or conservative management. Education and knowledge transfer play key roles in this decision-making process, yet they remain a partially met need.

Objective: We sought to understand the dialysis modality decision-making process through exploration of the predialysis patient experience to better inform the educational process. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118803323
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http://dx.doi.org/10.1177/2054358118803323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178119PMC
October 2018
16 Reads

Severe Acute Kidney Injury and Multiple Organ Failure in a 17-Day-Old Newborn: When Pathology Makes the Difference.

Can J Kidney Health Dis 2018 6;5:2054358118804834. Epub 2018 Oct 6.

Division of Nephrology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, QC, Canada.

Rationale: Acute tubulointerstitial nephritis (ATIN) in children is most commonly due to allergic drug reactions. In neonates, diagnosis of ATIN is clinically suspected and a kidney biopsy is not routinely performed.

Presenting Concern: A 17-day-old newborn presented with vomiting and dehydration, along with anuric acute kidney injury, severe electrolyte disturbances, hypocomplementemia, and thrombocytopenia. Read More

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http://dx.doi.org/10.1177/2054358118804834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174648PMC
October 2018
4 Reads

Acute Kidney Injury Due to Inferior Vena Cava Stenosis After Liver Transplantation: A Case Report About the Importance of Hepatic Vein Doppler Ultrasound and Clinical Assessment.

Can J Kidney Health Dis 2018 3;5:2054358118801012. Epub 2018 Oct 3.

Department of Anesthesiology and Intensive care, Centre Hospitalier de l'Université de Montréal, QC, Canada.

Rationale: Acute kidney injury (AKI) is a frequent complication after liver transplantation. In some patients, prompt intervention targeted at a specific etiology is of paramount importance.

Presenting Concerns Of The Patients: A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. Read More

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http://dx.doi.org/10.1177/2054358118801012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172939PMC
October 2018
21 Reads

Predicting 3-Year Survival in Patients Receiving Maintenance Dialysis: An External Validation of iChoose Kidney in Ontario, Canada.

Can J Kidney Health Dis 2018 4;5:2054358118799693. Epub 2018 Oct 4.

Institute for Clinical Evaluative Sciences, London, ON, Canada.

Background: Many patients with end-stage kidney disease (ESKD) do not appreciate how their survival may differ if treated with a kidney transplant compared with dialysis. A risk calculator (iChoose Kidney) developed and validated in the United States provides individualized mortality estimates for different treatment options (dialysis vs living or deceased donor kidney transplantation). The calculator can be used with patients and families to help patients make more educated treatment decisions. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118799693
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http://dx.doi.org/10.1177/2054358118799693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172940PMC
October 2018
1 Read

The Effect of N-Acetylcysteine on Creatinine Measurement: Protocol for a Systematic Review.

Can J Kidney Health Dis 2018 24;5:2054358118801017. Epub 2018 Sep 24.

The Ottawa Hospital, University of Ottawa, ON, Canada.

Background: N-acetylcysteine (NAC) is an antioxidant which can regenerate glutathione and is primarily used for acetaminophen overdose. It is also a potential therapy to prevent iatrogenic acute kidney injury or slow the progression of chronic kidney disease. It has been considered in this context by many studies with mixed results. Read More

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http://dx.doi.org/10.1177/2054358118801017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156188PMC
September 2018
16 Reads

Trends in Biopsy-Based Diagnosis of Kidney Disease: A Population Study.

Can J Kidney Health Dis 2018 20;5:2054358118799690. Epub 2018 Sep 20.

Department of Medicine, University of Calgary, AB, Canada.

Background: Kidney biopsy is considered the gold standard for diagnosis of renal disease. It is increasingly performed in cases of diagnostic uncertainty, including in patients with coexistent diabetes and hypertension, for which a presumptive clinical diagnosis can be made. Little is known about the incidence and distribution of biopsy-proven kidney diseases. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118799690
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http://dx.doi.org/10.1177/2054358118799690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149029PMC
September 2018
24 Reads

A Retrospective Study of Chronic Kidney Disease Burden in Saskatchewan's First Nations People.

Can J Kidney Health Dis 2018 17;5:2054358118799689. Epub 2018 Sep 17.

Section of Nephrology, Department of Medicine, Saskatchewan Health Authority, Regina, Canada.

Background: Chronic kidney disease is more prevalent among First Nations people than in non-First Nations people. Emerging research suggests that First Nations people are subject to greater disease burden than non-First Nations people.

Objective: We aimed to identify the severity of chronic kidney disease and quantify the geographical challenges of obtaining kidney care by Saskatchewan's First Nations people. Read More

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http://dx.doi.org/10.1177/2054358118799689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144512PMC
September 2018
5 Reads

Incidence Rate of Post-Kidney Transplant Infection: A Retrospective Cohort Study Examining Infection Rates at a Large Canadian Multicenter Tertiary-Care Facility.

Can J Kidney Health Dis 2018 12;5:2054358118799692. Epub 2018 Sep 12.

Clinical Epidemiology Program, The Ottawa Hospital Research Institute, ON, Canada.

Background: Reducing post-operative infections among kidney transplant patients is critical to improve long-term outcomes. With shifting disease demographics and implementation of new transplantation protocols, frequent evaluation of infection rate and type is necessary.

Objective: Our objectives were to assess the incidence and types of post-operative infections in kidney transplant recipients at a large tertiary-care facility and determine sample sizes needed for future intervention trials. Read More

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http://dx.doi.org/10.1177/2054358118799692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136109PMC
September 2018
16 Reads

Effectiveness of a Web-Based eHealth Portal for Delivery of Care to Home Dialysis Patients: A Single-Arm Pilot Study.

Can J Kidney Health Dis 2018 7;5:2054358118794415. Epub 2018 Sep 7.

Dalhousie University, Halifax, NS, Canada.

Background: Improving a patient's experience with their care through an online interface for communication (an eHealth patient portal) has been shown to be beneficial in some studies of chronic disease populations. However, little is known about the effectiveness of an eHealth portal for delivery of care to home dialysis patients.

Objectives: To determine whether an eHealth portal is effective at improving a patient's experience with their home dialysis care. Read More

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http://dx.doi.org/10.1177/2054358118794415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130084PMC
September 2018
5 Reads

The Risk of Adverse Events in Patients With Polycystic Kidney Disease With Advanced Chronic Kidney Disease.

Can J Kidney Health Dis 2018 8;5:2054358118774537. Epub 2018 Jun 8.

Department of Medicine, University of Ottawa, Ontario, Canada.

Background: Polycystic kidney disease (PKD) leads to progressive chronic kidney disease (CKD) with a subsequent risk of adverse events such as cardiac disease, infections, end-stage kidney disease (ESKD), and mortality.

Objectives: To determine the risks of CKD-related adverse outcomes in patients with PKD compared with patients without PKD.

Setting: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) was a prospective pan-Canadian cohort study from 2008-2013 involving 28 facilities with adjudicated outcomes. Read More

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http://dx.doi.org/10.1177/2054358118774537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117870PMC
June 2018
6 Reads

Cannabinoid Hyperemesis Syndrome Masquerading as Uremia: An Educational Case Report.

Can J Kidney Health Dis 2018 24;5:2054358118791146. Epub 2018 Aug 24.

Kidney Health, Saskatchewan Health Authority, Saskatoon, Canada.

Rationale: With marijuana legalization, clinicians need to be aware of Cannabinoid Hyperemesis Syndrome (CHS), which may masquerade as other disease states such as uremia.

Presenting Concerns Of The Patient: A 37-year-old man with bipolar affective disease treated with lithium had progressive renal insufficiency presumably on the basis of interstitial fibrosis. He developed persistent and severe nausea and vomiting which was assumed to be on the basis of uremia. Read More

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http://dx.doi.org/10.1177/2054358118791146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109838PMC
August 2018
18 Reads

Antibiotic Dosing in Sustained Low-Efficiency Dialysis in Critically Ill Patients.

Can J Kidney Health Dis 2018 10;5:2054358118792229. Epub 2018 Aug 10.

Cleveland Clinic Akron General/Akron Nephrology Associates, OH, USA.

Purpose Of Review: Sustained low-efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. There is, therefore, a greater need for the understanding of the antibiotic dosage and pharmacokinetics in these patients, to provide them with optimal therapy.

Sources Of Information: PubMed/Medline, Embase, and Google Scholar. Read More

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http://dx.doi.org/10.1177/2054358118792229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088477PMC
August 2018
1 Read

Association Between Low-Molecular-Weight Heparin and Risk of Bleeding Among Hemodialysis Patients: A Retrospective Cohort Study.

Can J Kidney Health Dis 2018 2;5:2054358118792010. Epub 2018 Aug 2.

Centre de recherche Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.

Background: Low-molecular-weight heparins (LMWH) replaced unfractionated heparin (UFH) in multiple indications. Although LMWH efficacy in hemodialysis was demonstrated through multiple studies, their safety remains controversial. The potential bioaccumulation in patients undergoing chronic hemodialysis raised the question of bleeding risk among this population. Read More

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http://dx.doi.org/10.1177/2054358118792010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088481PMC
August 2018
20 Reads

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.

Can J Kidney Health Dis 2018 2;5:2054358118789158. Epub 2018 Aug 2.

Division of Nephrology, University of California, San Francisco, USA.

Background: Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS).

Objective: To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS.

Design: Secondary analysis of data from Statins for Acutely Injured Lungs in Sepsis (SAILS), a randomized controlled trial that tested the impact of rosuvastatin therapy on mortality in patients with sepsis-associated ARDS. Read More

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http://dx.doi.org/10.1177/2054358118789158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088470PMC
August 2018
9 Reads

Late-Onset Systemic Lupus Erythematosus With Lupus Nephritis in a 74-Year-Old Male: A Brief Case and Review.

Can J Kidney Health Dis 2018 6;5:2054358118793397. Epub 2018 Aug 6.

Department of Nephrology, Kingston General Hospital, Queen's University, ON, Canada.

Rationale: Late-onset systemic lupus erythematosus (SLE) represents a specific subgroup of SLE, and although there is no strict age cut-off, 50 years is commonly used as the minimum age for disease onset. In this report, we present a case of a 74-year-old male with late-onset SLE and biopsy-proven lupus nephritis (LN).

Presenting Concerns Of The Patient: A 74-year-old male was referred to the nephrology clinic with a rapidly rising creatinine from a baseline of 60 µmol/L to 176 µmol/L. Read More

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http://dx.doi.org/10.1177/2054358118793397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081753PMC
August 2018
4 Reads

Prediction of Acute Kidney Injury With a Machine Learning Algorithm Using Electronic Health Record Data.

Can J Kidney Health Dis 2018 8;5:2054358118776326. Epub 2018 Jun 8.

Dascena, Inc, Hayward, CA, USA.

Background: A major problem in treating acute kidney injury (AKI) is that clinical criteria for recognition are markers of established kidney damage or impaired function; treatment before such damage manifests is desirable. Clinicians could intervene during what may be a crucial stage for preventing permanent kidney injury if patients with incipient AKI and those at high risk of developing AKI could be identified.

Objective: In this study, we evaluate a machine learning algorithm for early detection and prediction of AKI. Read More

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http://dx.doi.org/10.1177/2054358118776326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080076PMC
June 2018
5 Reads

Is the Kidney Donor Risk Index a Useful Tool in Non-US Patients?

Can J Kidney Health Dis 2018 27;5:2054358118791148. Epub 2018 Jul 27.

Department of Medicine, University of Toronto, ON, Canada.

Background: Deceased donor kidney allocation in the United States is guided by the Kidney Donor Risk Index (KDRI). The generalizability of the KDRI beyond the United States has not been widely studied.

Objective: To assess the generalizability of the KDRI in a cohort of non-US (Canadian) deceased donor kidney transplant recipients. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118791148
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http://dx.doi.org/10.1177/2054358118791148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073818PMC
July 2018
4 Reads

Follow-up Care of Living Kidney Donors in Alberta, Canada.

Can J Kidney Health Dis 2018 26;5:2054358118789366. Epub 2018 Jul 26.

Department of Medicine, Division of Nephrology, Western University, London, ON, Canada.

Background: Previous guidelines recommend that living kidney donors receive lifelong annual follow-up care to assess renal health.

Objective: To determine whether these best practice recommendations are currently being followed.

Design: Retrospective cohort study using linked health care databases. Read More

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http://dx.doi.org/10.1177/2054358118789366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073841PMC
July 2018
9 Reads

Home Palliative Service Utilization and Care Trajectory Among Ontario Residents Dying on Chronic Dialysis.

Can J Kidney Health Dis 2018 24;5:2054358118783761. Epub 2018 Jul 24.

Division of Nephrology and Immunology, Faculty of Medicine, University of Alberta, Edmonton, Canada.

Background: Many patients who receive chronic hemodialysis have a limited life expectancy comparable to that of patients with metastatic cancer. However, patterns of home palliative care use among patients receiving hemodialysis are unknown.

Objectives: We aimed to undertake a current-state analysis to inform measurement and quality improvement in palliative service use in Ontario. Read More

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http://dx.doi.org/10.1177/2054358118783761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073817PMC
July 2018
4 Reads

Explore Transplant Ontario: Adapting the Explore Transplant Education Program to Facilitate Informed Decision Making About Kidney Transplantation.

Can J Kidney Health Dis 2018 24;5:2054358118789369. Epub 2018 Jul 24.

Division of Nephrology, University of California, Los Angeles, CA, USA.

Purpose: In this article, we describe a province-wide collaborative project in which we adapted the Explore Transplant (ET) education program for use in Ontario, Canada, to develop Explore Transplant Ontario (ETO). Kidney transplantation (KT), especially living donor kidney transplantation (LDKT), is the best treatment for many patients with end-stage kidney disease (ESKD), with the best patient survival and quality of life and also reduced health care costs. Yet KT and LDKT are underutilized both internationally and in Canada. Read More

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http://dx.doi.org/10.1177/2054358118789369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058418PMC
July 2018
1 Read

Opportunities and Challenges for Genetic Studies of End-Stage Renal Disease in Canada.

Can J Kidney Health Dis 2018 22;5:2054358118789368. Epub 2018 Jul 22.

Division of Nephrology, University Health Network, Toronto, ON, Canada.

Purpose Of Review: Genetic testing can improve diagnostic precision in some patients with end-stage renal disease (ESRD) providing the potential for targeted therapy and improved patient outcomes. We sought to describe the genetic architecture of ESRD and Canadian data sources available for further genetic investigation into ESRD.

Sources Of Information: We performed PubMed searches of English, peer-reviewed articles using keywords "chronic kidney disease," "ESRD," "genetics," "sequencing," and "administrative databases," and searched for nephrology-related Mendelian diseases on the Online Mendelian Inheritance in Man database. Read More

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http://dx.doi.org/10.1177/2054358118789368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056781PMC
July 2018
1 Read

Thiazide Diuretic Dose and Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study.

Can J Kidney Health Dis 2018 15;5:2054358118787480. Epub 2018 Jul 15.

Departments of Medicine and Community Health Sciences, University of Calgary, AB, Canada.

Background: Thiazide diuretics are commonly prescribed to prevent kidney stones. However, it is unclear whether higher doses confer greater benefit.

Objective: To determine whether lower doses of thiazide diuretics confer a similar protective effect against kidney stone events as higher doses. Read More

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http://dx.doi.org/10.1177/2054358118787480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048667PMC
July 2018
3 Reads

Introduction of Competence by Design to Canadian Nephrology Postgraduate Training.

Can J Kidney Health Dis 2018 17;5:2054358118786972. Epub 2018 Jul 17.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Purpose Of The Review: The Royal College of Physicians and Surgeons of Canada, with its Competence by Design initiative, is adopting the principles of competency-based medical education for residency training and continuing professional development. This initiative is being undertaken to meet the new standards of medical education in Canada, which include social accountability to meet performance-based outcomes of training. Nephrology is poised to implement Competence by Design into residency training in July 2018 and initiate a continuous quality improvement cycle to periodically renew and update the training requirements to be socially accountable and relevant in the modern age of medicine. Read More

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http://dx.doi.org/10.1177/2054358118786972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050612PMC

Case Mix, Patterns of Care, and Inpatient Outcomes Among Ontario Kidney Transplant Centers: A Population-Based Study.

Can J Kidney Health Dis 2018 17;5:2054358117730053. Epub 2018 Jul 17.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ontario, Canada.

Background: Significant variation in both patient case mix and the structure of care in kidney transplantation has been previously described in the United States.

Objective: The objective of our study was to characterize patient case mix, patterns of care, and inpatient outcomes across 5 kidney transplant centers in the province of Ontario, Canada.

Design: This was a retrospective population-based cohort study using health care administrative databases. Read More

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http://dx.doi.org/10.1177/2054358117730053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050611PMC
July 2018
1 Read

Physical Activity in Patients Treated With Peritoneal Dialysis: A Systematic Review and Meta-analysis.

Can J Kidney Health Dis 2018 18;5:2054358118779821. Epub 2018 Jun 18.

University of Ottawa, ON, Canada.

Background: Exercise has been shown to be of benefit in the general population and in patients with chronic diseases. Despite a lack of compelling evidence, patients with end-stage kidney disease (ESKD) treated with peritoneal dialysis (PD) are often discouraged from participating in exercise programs that include weight lifting due to concerns about the development of hernias and leaks. The actual effects of physical activity with or without structured exercise programs for patients on PD remain unclear. Read More

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http://dx.doi.org/10.1177/2054358118779821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024495PMC
June 2018
17 Reads

Gadolinium-Based Contrast Agents in Kidney Disease: A Comprehensive Review and Clinical Practice Guideline Issued by the Canadian Association of Radiologists.

Can J Kidney Health Dis 2018 12;5:2054358118778573. Epub 2018 Jun 12.

Division of Nephrology, Department of Medicine and Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

Purpose Of Review: Use of gadolinium-based contrast agents (GBCA) in renal impairment is controversial, with physician and patient apprehension in acute kidney injury (AKI), chronic kidney disease (CKD), and dialysis because of concerns regarding nephrogenic systemic fibrosis (NSF). The position that GBCA are absolutely contraindicated in AKI, category G4 and G5 CKD (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m), and dialysis-dependent patients is outdated and may limit access to clinically necessary contrast-enhanced magnetic resonance imaging (MRI) examinations. Read More

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http://dx.doi.org/10.1177/2054358118778573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024496PMC
June 2018
3 Reads

End-Stage Kidney Disease in Patients With Autosomal Dominant Polycystic Kidney Disease: A 12-Year Study Based on the Canadian Organ Replacement Registry.

Can J Kidney Health Dis 2018 11;5:2054358118778568. Epub 2018 Jun 11.

University of Ottawa, ON, Canada.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with afflicted patients often progressing to end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT). As the timelines to ESKD are predictable over decades, it follows that ADPKD patients should be optimized regarding kidney transplantation, home dialysis therapies, and vascular access.

Objectives: To examine the association of kidney transplantation, dialysis modalities, and vascular access in ADPKD patients compared with a matched, non-ADPKD cohort. Read More

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http://journals.sagepub.com/doi/10.1177/2054358118778568
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http://dx.doi.org/10.1177/2054358118778568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024346PMC
June 2018
13 Reads

Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety?

Can J Kidney Health Dis 2018 17;5:2054358118777133. Epub 2018 Jun 17.

Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Purpose Of Review: One of the principal mechanisms by which illness can affect driving safety is by impairing cognition. Nevertheless, despite the substantial evidence demonstrating cognitive impairment in chronic kidney disease (CKD), little is known about the effects of CKD on driving safety.

Objective: Investigate the current national medical guidelines and research literature with respect to CKD and driving safety. Read More

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http://dx.doi.org/10.1177/2054358118777133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024330PMC
June 2018
2 Reads

Hospitalizations in Dialysis Patients in Canada: A National Cohort Study.

Can J Kidney Health Dis 2018 1;5:2054358118780372. Epub 2018 Jun 1.

Division of Nephrology, Department of Medicine, University of Ottawa, Ontario, Canada.

Background: Hospitalizations of chronic dialysis patients have not been previously studied at a national level in Canada. Understanding the scope and variables associated with hospitalizations will inform measures for improvement.

Objective: To describe the risk of all-cause and infection-related hospitalizations in patients on dialysis. Read More

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http://dx.doi.org/10.1177/2054358118780372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985541PMC
June 2018
5 Reads

Transfusion Management of Incident Dialysis Patients in Canada: A Prospective Observational Study.

Can J Kidney Health Dis 2018 5;5:2054358118778564. Epub 2018 Jun 5.

University Western Ontario, London, Canada.

Background: Several studies have demonstrated harm associated with using erythropoiesis-stimulating agents (ESA) to achieve higher hemoglobin (Hb) levels. Subsequently, more conservative use of ESAs has changed anemia therapy in patients with chronic renal failure.

Objective: The objectives were to identify transfusion rates in hemodialysis (HD) patients during the first year of therapy, to identify factors associated with the probability of transfusion, describe reasons for the transfusions, and identify the Hb values associated with each transfusion. Read More

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http://dx.doi.org/10.1177/2054358118778564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992794PMC
June 2018
5 Reads