352 results match your criteria Canadian journal of kidney health and disease[Journal]


Evaluation of Urinary NGAL as a Diagnostic Tool for Acute Kidney Injury in Critically Ill Patients With Infection: An Original Study.

Can J Kidney Health Dis 2020 19;7:2054358120934215. Epub 2020 Jun 19.

Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Background: Acute kidney injury (AKI) is a common complication in critical care patients. The presence of AKI is a marker for poor outcomes such as longer hospitalization durations, more hospital readmissions, and especially, higher mortality rates. Sepsis is one of the major causes of AKI within the intensive care unit (ICU) population. Read More

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http://dx.doi.org/10.1177/2054358120934215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307396PMC

Effect of Maintenance Intravenous Iron Treatment on Erythropoietin Dose in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial.

Can J Kidney Health Dis 2020 19;7:2054358120933397. Epub 2020 Jun 19.

Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: There is no consensus on intravenous (IV) iron supplement dose, schedule, and serum ferritin target in functional iron deficiency anemia to maintain optimum target levels of iron stores by several guidelines.

Objective: To examine the effect of IV iron supplementation to different targets of serum ferritin on erythropoietin dose and inflammatory markers in chronic hemodialysis (HD) patients with functional iron deficiency anemia.

Design: A multicenter, randomized, open-label study. Read More

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http://dx.doi.org/10.1177/2054358120933397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307402PMC

Canadian Society of Transplantation and Canadian Society of Nephrology Commentary on the 2017 KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.

Can J Kidney Health Dis 2020 9;7:2054358120918457. Epub 2020 Jun 9.

Division of Nephrology, University of British Columbia, Vancouver, Canada.

Purpose Of Review: To review an international guideline on the evaluation and care of living kidney donors and provide a commentary on the applicability of the recommendations to the Canadian donor population.

Sources Of Information: We reviewed the 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors and compared this guideline to the Canadian 2014 Kidney Paired Donation (KPD) Protocol for Participating Donors.

Methods: A working group was formed consisting of members from the Canadian Society of Transplantation and the Canadian Society of Nephrology. Read More

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http://dx.doi.org/10.1177/2054358120918457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288834PMC

Pediatric Kidney Transplant Experience in Ontario: A Review of Division of the Surgical and Medical Management Across Local Tertiary Care Institutions.

Can J Kidney Health Dis 2020 8;7:2054358120925712. Epub 2020 Jun 8.

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Our institution is the largest pediatric kidney transplantation (KT) center in Canada and the referral center for pediatric KT in Ontario. Pediatric KT recipients are referred to our center for KT and transferred back to their local tertiary care institutions for post-transplant care. This investigation assesses whether the current system of transferring patients back to their local tertiary care institutions following KT allows decreased burden and distribution of resources from a single centralized surgical center. Read More

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http://dx.doi.org/10.1177/2054358120925712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285935PMC

PRISMA guideline compliance is imperative for systematic review appraisal.

Authors:
Sandra McKeown

Can J Kidney Health Dis 2020 8;7:2054358120927594. Epub 2020 Jun 8.

Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1177/2054358120927594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281638PMC

Validation of the Kidney Failure Risk Equation in Kidney Transplant Recipients.

Can J Kidney Health Dis 2020 25;7:2054358120922627. Epub 2020 May 25.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, ON, Canada.

Background: Predicting allograft failure in kidney transplant recipients can help plan renal replacement therapy and guide patient-provider communication. The kidney failure risk equation (KFRE) accurately predicts the need for dialysis in patients with chronic kidney disease (CKD), but has not been validated in kidney transplant recipients.

Objective: We sought to validate the 4-variable KFRE (age, sex, estimated glomerular filtration rate [eGFR], and urine albumin-to-creatinine ratio [ACR]) for prediction of 2- and 5-year death-censored allograft failure. Read More

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http://dx.doi.org/10.1177/2054358120922627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249550PMC

Economic Benefits of Switching From Intravenous to Subcutaneous Epoetin Alfa for the Management of Anemia in Hemodialysis Patients.

Can J Kidney Health Dis 2020 4;7:2054358120927532. Epub 2020 Jun 4.

Cumming School of Medicine, University of Calgary, AB, Canada.

Background: Erythropoiesis-stimulating agents including epoetin alfa have been a mainstay of anemia management in patients with chronic kidney disease. Although the standard practice has been to administer epoetin alfa to patients on hemodialysis (HD) intravenously (IV), subcutaneous (SQ) epoetin alfa is longer acting and achieve the same target hemoglobin level to be maintained at a reduced dose and cost.

Objective: The primary objective of this study was to determine the economic benefits of change in route of epoetin alfa administration from IV to SQ in HD patients. Read More

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http://dx.doi.org/10.1177/2054358120927532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273547PMC

The Impact of a New Triage and Booking System on Renal Clinic Wait Times.

Can J Kidney Health Dis 2020 2;7:2054358120924140. Epub 2020 Jun 2.

Nova Scotia Health Authority, Halifax, Canada.

Background: Prolonged wait times are known barriers to accessing nephrology care for patients needing more urgent specialist services. Improved process and standardized triage systems are known to minimize wait times of urgent or semi-urgent care in health care disciplines. In Central Zone (CZ) renal clinic, mean wait times for urgent (P1) and semi-urgent (P2) referrals were prolonged before 2014. Read More

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http://dx.doi.org/10.1177/2054358120924140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271271PMC

Frequency, Timing, and Prediction of Major Bleeding Complications From Percutaneous Renal Biopsy.

Can J Kidney Health Dis 2020 25;7:2054358120923527. Epub 2020 May 25.

Division of Nephrology, Department of Medicine, Schulich School of Medicine & Dentistry, Western Ontario, London, Canada.

Background And Objectives: The risk and timing of bleeding events following ultrasound-guided percutaneous renal biopsy are not clearly defined.

Design Setting Participants And Measurements: We performed a retrospective study of 617 consecutive adult patients who underwent kidney biopsy between 2012 and 2017 at a tertiary academic hospital in London, Canada. We assessed frequency and timing of minor (not requiring intervention) and major (requiring blood transfusion, surgery, or embolization) bleeds and developed a personalized risk calculator for these. Read More

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http://dx.doi.org/10.1177/2054358120923527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251654PMC

Canadian Society of Nephrology COVID-19 Rapid Response Team Home Dialysis Recommendations.

Can J Kidney Health Dis 2020 29;7:2054358120928153. Epub 2020 May 29.

University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.

Purpose Of Program: This paper will provide guidance on how to best manage patients with end-stage kidney disease who will be or are being treated with home dialysis during the COVID-19 pandemic.

Sources Of Information: Program-specific documents, pre-existing, and related to COVID-19; documents from national and international kidney agencies; national and international webinars, including webinars that we hosted for input and feedback; with additional information from formal and informal review of published academic literature.

Methods: Members of the Canadian Society of Nephrology (CSN) Board of Directors solicited a team of clinicians and administrators with expertise in home dialysis. Read More

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http://dx.doi.org/10.1177/2054358120928153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262737PMC

Crystalglobulinemia in Multiple Myeloma: A Rare Case Report of Survival and Renal Recovery.

Can J Kidney Health Dis 2020 18;7:2054358120922629. Epub 2020 May 18.

Renal Department, St George Hospital, Kogarah, NSW, Australia.

Rationale: Crystalglobulinemia is a rare complication of monoclonal gammopathy wherein crystallized immunoglobulins deposit in various organs causing occlusive vasculopathy, endothelial damage, and thrombosis. It should be differentiated from light chain cast nephropathy without crystalline nephropathy through timely diagnosis with a kidney biopsy.

Presenting Concerns Of The Patient: We report a case of a 74-year-old female with polyarthralgia, chest pain, petechial rash, and acute kidney injury. Read More

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http://dx.doi.org/10.1177/2054358120922629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235647PMC

Community Pharmacy-Based eGFR Screening for Early Detection of CKD in High Risk Patients.

Can J Kidney Health Dis 2020 18;7:2054358120922617. Epub 2020 May 18.

Department of Pharmacy, Sint Maartenskliniek. Nijmegen, The Netherlands.

Background: Chronic kidney disease (CKD) is a condition presenting with long-term slow progression of structural and/or functional damage to the kidneys. Early detection is key to preventing complications and improving outcomes. Point-of-care estimated glomerular filtration rate (eGFR) screening technology allows for detection of abnormal kidney function in the community pharmacy setting. Read More

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http://dx.doi.org/10.1177/2054358120922617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235648PMC

Community-Based Dialysis in Saskatchewan First Nations: A Grassroots Approach to Gaining Insight and Perspective From First Nations Patients With Chronic Kidney Disease.

Can J Kidney Health Dis 2020 20;7:2054358120914689. Epub 2020 May 20.

Saskatchewan Health Authority, Regina, SK, Canada.

Background: Renal replacement options or dialysis can be delivered in the home setting or hospital setting. Home dialysis offers a number of benefits over hospital-delivered dialysis. These advantages include improved quality of life, less travel, and fewer dietary restrictions. Read More

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http://dx.doi.org/10.1177/2054358120914689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241204PMC

Determinants of Poor Glycemic Control in Patients with Kidney Transplants: A Single-Center Retrospective Cohort Study in Canada.

Can J Kidney Health Dis 2020 18;7:2054358120922628. Epub 2020 May 18.

Faculty of Medicine, University of Ottawa, ON, Canada.

Background: Kidney transplant immunosuppressive medications are known to impair glucose metabolism, causing worsened glycemic control in patients with pre-transplant diabetes mellitus (PrTDM) and new onset of diabetes after transplant (NODAT).

Objectives: To determine the incidence, risk factors, and outcomes of both PrTDM and NODAT patients.

Design: This is a single-center retrospective observational cohort study. Read More

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http://dx.doi.org/10.1177/2054358120922628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235535PMC

The Burden of Frailty on Mood, Cognition, Quality of Life, and Level of Independence in Patients on Hemodialysis: Regina Hemodialysis Frailty Study.

Can J Kidney Health Dis 2020 2;7:2054358120917780. Epub 2020 May 2.

Section of Nephrology, Department of Medicine, Regina General Hospital, SK, Canada.

Background: The prevalence of frailty is disproportionately increased in patients with chronic kidney disease (CKD) in comparison with non-CKD counterparts and is the highest in patients on hemodialysis (HD). While the cross-sectional measurement of frailty on HD has been associated with adverse clinical events, there is a paucity of data on longitudinal assessment of frailty and its relationship to outcomes.

Objective: The objectives were to (1) evaluate changes in frailty status, level of independence, mood, cognition, and quality of life (QoL) over a 12-month period and (2) explore the relationship between frailty status and level of independence, mood, cognition, and QoL at 2 different time points (at baseline and at 1 year). Read More

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http://dx.doi.org/10.1177/2054358120917780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218321PMC

Co-Developed Indigenous Educational Materials for Chronic Kidney Disease: A Scoping Review.

Can J Kidney Health Dis 2020 4;7:2054358120916394. Epub 2020 May 4.

College of Nursing, University of Saskatchewan, Saskatoon, Canada.

Background: Canadian Indigenous populations experience significantly more chronic kidney disease (CKD) than the general population. Indigenous people who live in rural and remote areas may also have difficulty accessing both information and care for their CKD. Informed decision making about treatment options for advancing kidney disease may be delayed, which can result in poor health outcomes and decreased quality of life. Read More

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http://dx.doi.org/10.1177/2054358120916394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218329PMC

Preference for Alternate-Day Versus Conventional In-Center Dialysis: A Health Utility Elicitation.

Can J Kidney Health Dis 2020 26;7:2054358120914426. Epub 2020 Apr 26.

Department of Medicine, University of Toronto, ON, Canada.

Background: Mortality rates for patients on hemodialysis (HD) continue to be high, in particular, following the long interdialytic period, yet thrice-weekly conventional HD (CHD) is still an almost universal regimen. Alternate-day dialysis (ADD) may have advantages over the current schedule because it would eliminate the long interdialytic break. A preliminary, as yet unpublished, patient simulation and cost-utility analysis compared CHD versus ADD and demonstrated that the economic attractiveness of ADD was sensitive, in particular, to patients' preference for ADD versus CHD. Read More

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http://dx.doi.org/10.1177/2054358120914426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218335PMC

Prescription Patterns in Dialysis Patients: Differences Between Hemodialysis and Peritoneal Dialysis Patients and Opportunities for Deprescription.

Can J Kidney Health Dis 2020 1;7:2054358120912652. Epub 2020 May 1.

St. Paul's Hospital, Providence Health Care, Vancouver, BC, Canada.

Background: Patients treated with maintenance dialysis are at high risk of polypharmacy given their many comorbidities as well as complications from their disease state and treatment. The prescribing patterns and burden of polypharmacy in patients treated with maintenance dialysis, and specifically the difference between hemodialysis (HD) and peritoneal dialysis (PD) prescribing, are not well characterized.

Objectives: The objectives of this study were to review the prescribing patterns for patients treated with maintenance dialysis, to compare prescribing pattern between HD and PD, and to identify opportunities for deprescription. Read More

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http://dx.doi.org/10.1177/2054358120912652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218341PMC

A Proof-of-Concept Investigation of an Energy Management Education Program to Improve Fatigue and Life Participation in Adults on Chronic Dialysis.

Can J Kidney Health Dis 2020 16;7:2054358120916297. Epub 2020 Apr 16.

Division of Nephrology, University Health Network, Toronto, ON, Canada.

Background: Fatigue and its negative impact on life participation are top research priorities of people on chronic dialysis therapy. Energy management education (EME) is a fatigue management approach that teaches people to use practical strategies (eg, prioritizing, using efficient body postures, organizing home environments) to manage their energy expenditure during everyday life.

Objective: The aim of this study is to explore whether EME is associated with improvements in fatigue and life participation in adults on chronic dialysis. Read More

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http://dx.doi.org/10.1177/2054358120916297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163233PMC

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

Can J Kidney Health Dis 2020 14;7:2054358120908677. Epub 2020 Apr 14.

Cumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.

Background: Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.

Objective: To compare mortality and morbidity in kidney transplant recipients with a failing graft to matched nontransplant controls. Read More

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http://dx.doi.org/10.1177/2054358120908677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158256PMC

Policy Challenges for Organ Allocation in an Era of "Precision Medicine".

Can J Kidney Health Dis 2020 20;7:2054358120912655. Epub 2020 Mar 20.

Faculty of Medicine, The University of British Columbia, Vancouver, Canada.

There is increasing interest in the use of precision medicine tools and evidence-based outcome measures for donor-recipient matching to optimize transplant outcomes. Although the shift toward greater precision can provide health and resource benefits, it may be perceived as conflicting with both established equity-focused organ allocation norms and the legal and ethical obligations of health care providers and related institutions. With increasing evidence that various forms of human leukocyte antigen (HLA) mismatch and/or prognostic biomarkers can affect outcomes, the tension between maximizing utility and ensuring equity seems likely to intensify. Read More

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http://dx.doi.org/10.1177/2054358120912655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088188PMC

Prediction of Progression in Polycystic Kidney Disease Using the Kidney Failure Risk Equation and Ultrasound Parameters.

Can J Kidney Health Dis 2020 18;7:2054358120911274. Epub 2020 Mar 18.

Department of Medicine, Division of Nephrology, Kidney Research Centre, University of Ottawa, ON, Canada.

Background: The kidney failure risk equation (KFRE) is a validated risk algorithm for predicting the risk of kidney failure in chronic kidney disease (CKD) patients regardless of etiology. Patients with autosomal dominant polycystic kidney disease (AD-PCKD) experience long disease trajectories and as such identifying individuals at risk of kidney failure would aid in intervention.

Objective: To examine the utility of the KFRE in predicting adverse kidney outcomes compared with existing risk factors in a cohort of patients with AD-PCKD. Read More

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http://dx.doi.org/10.1177/2054358120911274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081470PMC

Kidney Health for Everyone Everywhere: From Prevention to Detection and Equitable Access to Care.

Can J Kidney Health Dis 2020 10;7:2054358120910569. Epub 2020 Mar 10.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the fifth most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual health care budget in high-income countries. Read More

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http://dx.doi.org/10.1177/2054358120910569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066467PMC

Utility of Rapid Influenza Molecular Testing in an Outpatient Hemodialysis Unit: A Prospective Cohort Study.

Can J Kidney Health Dis 2020 26;7:2054358120907816. Epub 2020 Feb 26.

Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada.

Background: Early initiation of antiviral therapy for individuals at risk for severe influenza infection is important for improving patient outcomes. Current guidelines recommend empiric antiviral therapy for patients with end-stage kidney disease presenting with suspected influenza infection. Rapid molecular influenza assays may reduce diagnostic uncertainty and improve patient outcomes by providing faster diagnostics compared to traditional batched polymerase chain reaction (PCR) testing. Read More

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http://dx.doi.org/10.1177/2054358120907816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045293PMC
February 2020

Use of the Living Kidney Donor Profile Index in the Canadian Kidney Transplant Recipient Population: A Validation Study.

Can J Kidney Health Dis 2020 20;7:2054358120906976. Epub 2020 Feb 20.

The Kidney Transplant Program and the Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.

Background: The Living Kidney Donor Profile Index (LKDPI) was derived in a cohort of kidney transplant recipients (KTR) from the United States to predict the risk of total graft failure. There are important differences in patient demographics, listing practices, access to transplantation, delivery of care, and posttransplant mortality in Canada as compared with the United States, and the generalizability of the LKDPI in the Canadian context is unknown.

Objective: The purpose of this study was to externally validate the LKDPI in a large contemporary cohort of Canadian KTR. Read More

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http://dx.doi.org/10.1177/2054358120906976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036490PMC
February 2020

Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.

Can J Kidney Health Dis 2020 22;7:2054358120906974. Epub 2020 Feb 22.

Department of Medicine, The Ottawa Hospital, University of Ottawa, ON, Canada.

Background: Increased carotid-femoral pulse wave velocity (cf-PWV), a surrogate of increased aortic stiffness, is a risk factor for cardiovascular events and all-cause mortality in end-stage renal disease (ESRD). To minimize the deleterious effects of an increased aortic stiffness in ESRD patients, several interventions have been developed and cf-PWV has been used to monitor responses.

Objective: The aim of this study was to determine the effects of pharmacologic interventions that target aortic stiffness on cf-PWV and systolic blood pressure (SBP) in adults with ESRD. Read More

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http://dx.doi.org/10.1177/2054358120906974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036505PMC
February 2020

Perceived and Objective Kidney Disease Knowledge in Patients With Advanced CKD Followed in a Multidisciplinary CKD Clinic.

Can J Kidney Health Dis 2020 11;7:2054358120903156. Epub 2020 Feb 11.

Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: One of the key components of multidisciplinary CKD clinics is education; however, kidney disease knowledge among patients followed in these clinics is not routinely measured.

Objective: The aim of this study was to determine objective and perceived kidney disease knowledge and patient characteristics associated with knowledge among patients followed in a multi-care kidney clinic.

Design: This is a cross-sectional survey study. Read More

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http://dx.doi.org/10.1177/2054358120903156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016305PMC
February 2020

Major Outcomes With Personalized Dialysate TEMPerature (MyTEMP): Rationale and Design of a Pragmatic, Registry-Based, Cluster Randomized Controlled Trial.

Can J Kidney Health Dis 2020 5;7:2054358119887988. Epub 2020 Feb 5.

London Health Sciences Centre, ON, Canada.

Background: Small randomized trials demonstrated that a lower compared with higher dialysate temperature reduced the average drop in intradialytic blood pressure. Some observational studies demonstrated that a lower compared with higher dialysate temperature was associated with a lower risk of all-cause mortality and cardiovascular mortality. There is now the need for a large randomized trial that compares the effect of a low vs high dialysate temperature on major cardiovascular outcomes. Read More

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http://dx.doi.org/10.1177/2054358119887988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003172PMC
February 2020

Projecting the Number of Posttransplant Clinic Visits With a Rise in the Number of Kidney Transplants: A Case Study From Ontario, Canada.

Can J Kidney Health Dis 2020 25;7:2054358119898552. Epub 2020 Jan 25.

Division of Nephrology, Western University, London, ON, Canada.

Background: In Ontario, kidney transplants have risen by 4% annually in recent years. An understanding of how this will affect the future annual number of posttransplant follow-up visits informs how to organize and deliver care.

Objective: We projected the required number of annual posttransplant follow-up nephrology visits to inform posttransplant care delivery. Read More

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http://dx.doi.org/10.1177/2054358119898552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984421PMC
January 2020

Clinical Characteristics and Outcome of Canadian Patients Diagnosed With Atypical Hemolytic Uremic Syndrome.

Can J Kidney Health Dis 2020 24;7:2054358119897229. Epub 2020 Jan 24.

Hôtel-Dieu de Québec, Quebec, QC, Canada.

Background: Atypical hemolytic uremic syndrome (aHUS) is an extremely rare, heterogeneous disease of uncontrolled activation of the alternative complement pathway that is difficult to diagnose. We have evaluated the Canadian patients enrolled in the Global aHUS Registry to provide a Canadian perspective regarding the diagnosis and management of aHUS and the specific challenges faced.

Objective: To evaluate Canadian patients enrolled in the Global aHUS Registry to provide a Canadian perspective regarding the diagnosis and management of aHUS and the specific challenges faced. Read More

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http://dx.doi.org/10.1177/2054358119897229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984425PMC
January 2020

Estimation of GFR in Patients With Cystic Fibrosis: A Cross-Sectional Study.

Can J Kidney Health Dis 2020 15;7:2054358119899312. Epub 2020 Jan 15.

Division of Paediatric Nephrology, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Background: Patients with cystic fibrosis (CF) have frequent infectious complications requiring nephrotoxic medications, necessitating monitoring of renal function. Although adult studies have suggested that cystatin C (CysC)-based estimated glomerular filtration rate (eGFR) may be preferable due to reduced muscle mass of patients with CF, pediatric patients remain understudied.

Objective: Our objective was to determine which eGFR formula is best for estimating glomerular filtration rate (GFR) in pediatric patients with CF. Read More

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http://dx.doi.org/10.1177/2054358119899312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966245PMC
January 2020

Significant Burden and Psychological Distress Among Caregivers of Children With Nephrotic Syndrome: A Cross-Sectional Study.

Can J Kidney Health Dis 2020 8;7:2054358119898016. Epub 2020 Jan 8.

Department of Psychiatry, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Mushin, Nigeria.

Background: Childhood nephrotic syndrome (NS) follows a chronic course in most children. However, little is known about the psychosocial burden of NS on the caregivers despite evidence that caregiver burden or impairment in their well-being may alter the outcome of chronic childhood illnesses.

Objectives: To determine the frequency and predictors of significant caregiver burden and psychological distress among caregivers of children with NS. Read More

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http://dx.doi.org/10.1177/2054358119898016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950537PMC
January 2020

The Prevalence of Nonadherence in Patients With Resistant Hypertension: A Systematic Review Protocol.

Can J Kidney Health Dis 2019 25;6:2054358119897196. Epub 2019 Dec 25.

University of Ottawa, ON, Canada.

Background: Resistant hypertension, usually defined as blood pressure remaining above goal despite the concurrent use of 3 or more antihypertensive agents of different classes, is common (about 10% prevalence) and known to be a risk factor for cardiovascular events. These patients also undergo more screening intensity for secondary hypertension. However, not all patients with apparent treatment-resistant hypertension have true resistant hypertension, with some of them being nonadherent to prescribed pharmacotherapy. Read More

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http://dx.doi.org/10.1177/2054358119897196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931137PMC
December 2019

DAMPAned Methotrexate: A Case Report and Review of the Management of Acute Methotrexate Toxicity.

Can J Kidney Health Dis 2019 21;6:2054358119895078. Epub 2019 Dec 21.

Nephrology, St. Michael's Hospital, University of Toronto, Ontario, Canada.

Rationale: Consensus guidelines on the management of methotrexate-induced nephrotoxicity using glucarpidase (Voraxaze) may be relatively unfamiliar to the nephrology community.

Presenting Concerns Of The Patient: A 61-year-old man with intravascular large B-cell lymphoma was admitted for cycle #1 of high-dose methotrexate (HDMTX) following 2 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. On admission, he was clinically euvolemic and had a creatinine clearance of 98 mL/min. Read More

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http://dx.doi.org/10.1177/2054358119895078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926974PMC
December 2019

Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018.

Can J Kidney Health Dis 2019 26;6:2054358119894394. Epub 2019 Dec 26.

ICES, ON, Canada.

Hemodialysis is a life-sustaining treatment for persons with kidney failure. However, those on hemodialysis still face a poor quality of life and a short life expectancy. High-quality research evidence from large randomized controlled trials is needed to identify interventions that improve the experiences, outcomes, and health care of persons receiving hemodialysis. Read More

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http://dx.doi.org/10.1177/2054358119894394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933546PMC
December 2019

The Potential Burden of Home Dialysis on Patients and Caregivers: A Narrative Review.

Can J Kidney Health Dis 2019 18;6:2054358119893335. Epub 2019 Dec 18.

Division of Nephrology, McGill University Health Centre, McGill University, Montreal, QC, Canada.

Purpose Of Review: Home dialysis modalities offer several benefits for patients with end-stage kidney disease when compared with facility-based thrice-weekly hemodialysis. To increase uptake of home dialysis, many centers are encouraging a "home-first" approach. However, it is important to appreciate that "one size may not fit all" and that dialysis modality selection is a complex decision that needs to be individualized. Read More

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http://dx.doi.org/10.1177/2054358119893335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920584PMC
December 2019

In Search of a Simple and Reliable Method of Measuring Intra-abdominal Pressure in Peritoneal Dialysis Patients.

Can J Kidney Health Dis 2019 6;6:2054358119892695. Epub 2019 Dec 6.

Division of Nephrology, Department of Medicine, Ottawa Hospital, ON, Canada.

Background: Patients treated with peritoneal dialysis (PD) are at increased risk of developing mechanical complications such as dialysate leaks and hernias thought to be partially related to an increase in intra-abdominal pressure (IAP) secondary to dialysate in the abdomen. However, measurement of IAP requires specialized equipment that is not readily available in the home dialysis unit.

Objectives: To develop a reliable method of measuring IAP in PD patients that could be easily used in the home dialysis unit. Read More

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http://dx.doi.org/10.1177/2054358119892695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900622PMC
December 2019

The Risk of Stroke and Stroke Type in Patients With Atrial Fibrillation and Chronic Kidney Disease.

Can J Kidney Health Dis 2019 4;6:2054358119892372. Epub 2019 Dec 4.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

Background: Atrial fibrillation (AF) and chronic kidney disease (CKD) are known to increase the risk of stroke.

Objectives: We set out to examine the risk of stroke by kidney function and albuminuria in patients with and without AF.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1177/2054358119892372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893926PMC
December 2019

Heterogeneity of Cause, Care, and Prognosis in Severe Acute Kidney Injury in Hospitalized Patients: A Prospective Observational Study.

Can J Kidney Health Dis 2019 4;6:2054358119892174. Epub 2019 Dec 4.

Service Nephrologie-Dialyse-Aphérèse, CHU Carémeau, Université de Montpellier-Nîmes, France.

Background: KDIGO (Kidney Disease: Improving Global Outcomes) defines acute kidney injury (AKI) solely by serum creatinine (SCr) and urine output variation. Severe AKI is a syndrome covering various clinical situations.

Objective: To describe severe AKI heterogeneity by department of hospitalization. Read More

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http://dx.doi.org/10.1177/2054358119892174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896136PMC
December 2019

Interventions to Improve Clinical Outcomes in Indigenous or Remote Patients With Chronic Kidney Disease: A Scoping Review.

Can J Kidney Health Dis 2019 14;6:2054358119887154. Epub 2019 Nov 14.

Division of Internal Medicine, Department of Medicine, Queen's University, Kingston, ON, Canada.

Background: Chronic kidney disease (CKD) associates with a significant health care burden with a disproportionate impact on indigenous persons or people living in remote areas. Although screening programs have expanded in these communities, there remains a paucity of evidence-based interventions to enhance clinical renal outcomes in these populations.

Objective: The objective of this study was to identify evidence-based interventions to enhance renal outcomes in these populations. Read More

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http://dx.doi.org/10.1177/2054358119887154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859680PMC
November 2019

The Influence of Age on the Likelihood of Catheter-Free Fistula Use in Hemodialysis Patients.

Can J Kidney Health Dis 2019 30;6:2054358119861943. Epub 2019 Jul 30.

Cumming School of Medicine, University of Calgary, AB, Canada.

Background: Clinical practice guidelines recommend arteriovenous fistulas as the preferred form of vascular access for hemodialysis. However, some studies have suggested that older age is associated with poorer fistula outcomes.

Objective: We assessed the impact of age on the outcomes of fistula creation and access-related procedures. Read More

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http://dx.doi.org/10.1177/2054358119861943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864041PMC

Don't Interrupt! A Case Report of Continuing Peritoneal Dialysis After Endoscopic Gastric Tumor Resection.

Can J Kidney Health Dis 2019 5;6:2054358119887147. Epub 2019 Nov 5.

Department of Medicine, University of Toronto, ON, Canada.

Rationale: The evidence supporting the safety of restarting peritoneal dialysis (PD) immediately after abdominal surgery and interventions is scant. In particular, there are no reported cases characterizing periprocedural management of PD for patients undergoing endoscopic submucosal dissection for gastric intramucosal tumor removal.

Presenting Concerns Of The Patient: A 66-year-old female with end-stage kidney disease secondary to diabetic nephropathy, currently on nocturnal automatic PD, presented with new iron-deficiency anemia. Read More

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http://dx.doi.org/10.1177/2054358119887147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836299PMC
November 2019

Long-Term Impact of Bariatric Surgery on Renal Outcomes at a Community-Based Publicly Funded Bariatric Program: The Regina Bariatric Study.

Can J Kidney Health Dis 2019 24;6:2054358119884903. Epub 2019 Oct 24.

Regina General Hospital, SK, Canada.

Background: Obesity is recognized as an independent risk factor for chronic kidney disease through multiple direct and indirect biological pathways. Bariatric surgery is a proven, effective method for sustained weight loss. However, there is a relative paucity of data on the impact of bariatric surgery on renal outcomes. Read More

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http://dx.doi.org/10.1177/2054358119884903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820179PMC
October 2019
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Acute Focal Bacterial Nephritis: Two Cases and Review of the Literature.

Can J Kidney Health Dis 2019 25;6:2054358119884310. Epub 2019 Oct 25.

University Hospital Sharjah, United Arab Emirates.

Rationale: Acute focal bacterial nephritis (AFBN) has mainly been reported in pediatrics. It may be an underdiagnosed condition in adults because it resembles acute pyelonephritis (APN) in its clinical presentation.

Presenting Concerns Of The Patients: Two young women (25 and 27 years old, respectively) presented with complaints compatible with a diagnosis of APN. Read More

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http://dx.doi.org/10.1177/2054358119884310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820168PMC
October 2019
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Prevalence and Correlates of Accelerometer-Based Physical Activity and Sedentary Time Among Kidney Transplant Recipients.

Can J Kidney Health Dis 2019 29;6:2054358119882658. Epub 2019 Oct 29.

Faculty of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Canada.

Background: Physical activity is recommended for kidney transplant recipents as it may improve outcomes including mortality, exercise capacity, muscle strength, and health-related quality of life.

Objective: The objective of this study was to examine accelerometer-based physical activity and sedentary time profiles among kidney transplant recipients and examine possible demographic and clinical correlates of physical activity and sedentary time.

Design: Cross-sectional. Read More

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http://dx.doi.org/10.1177/2054358119882658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820169PMC
October 2019

Multidisciplinary Chronic Kidney Disease Clinic Practices: A Scoping Review.

Can J Kidney Health Dis 2019 18;6:2054358119882667. Epub 2019 Oct 18.

St. Joseph's Healthcare Hamilton, ON, Canada.

Background: Multidisciplinary chronic kidney disease (CKD) clinics improve patient outcomes but their optimal design is unclear.

Objective: To perform a scoping review to identify and describe current practices (structure, function) associated with multidisciplinary CKD clinics.

Design: Scoping review. Read More

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http://dx.doi.org/10.1177/2054358119882667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801876PMC
October 2019
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Optimization of Dialysis Modality Transitions for Improved Patient Care.

Can J Kidney Health Dis 2019 16;6:2054358119882664. Epub 2019 Oct 16.

Division of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada.

Purpose Of Review: Initial and subsequent modality decisions are important, impacting both clinical outcomes and quality of life. Transition from chronic kidney disease to dialysis and between dialysis modalities are periods were patients may be especially vulnerable. Reviewing our current knowledge surrounding these critical periods and identifying areas for future research may allow us to develop dialysis strategies beneficial to patients. Read More

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http://dx.doi.org/10.1177/2054358119882664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798163PMC
October 2019

Acute Kidney Injury in Critically Ill Children and Subsequent Chronic Kidney Disease.

Can J Kidney Health Dis 2019 14;6:2054358119880188. Epub 2019 Oct 14.

Division of Nephrology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, QC, Canada.

Background: The progression from acute kidney injury (AKI) to chronic kidney disease (CKD) is not well understood in children.

Objectives: We aimed to develop a pediatric CKD definition using administrative data and use it to evaluate the association between AKI in critically ill children and CKD 5 years after hospital discharge.

Design: Retrospective cohort study using chart collection and administrative data. Read More

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http://dx.doi.org/10.1177/2054358119880188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794652PMC
October 2019

Protocol for the Study of Heart and Renal Protection-Extended Review: Additional 5-Year Follow-up of the Australian, New Zealand, and Malaysian SHARP Cohort.

Can J Kidney Health Dis 2019 14;6:2054358119879896. Epub 2019 Oct 14.

The George Institute for Global Health, Newtown, Australia.

Background: There are limited studies on the effects of statins on outcomes in the moderate chronic kidney disease (CKD) population and their trajectory to end-stage kidney disease.

Objective: To examine the long-term effects of lipid-lowering therapy on all-cause mortality, cardiovascular morbidity, CKD progression, and socioeconomic well-being in Australian, New Zealand, and Malaysian SHARP (Study of Heart and Renal Protection) trial participants-a randomized controlled trial of a combination of simvastatin and ezetimibe, compared with placebo, for the reduction of cardiovascular events in moderate to severe CKD.

Design: Protocol for an extended prospective observational follow-up. Read More

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http://dx.doi.org/10.1177/2054358119879896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794650PMC
October 2019

Roadblocks and Opportunities to the Implementation of Novel Therapies for Acute Kidney Injury: A Narrative Review.

Can J Kidney Health Dis 2019 9;6:2054358119880519. Epub 2019 Oct 9.

Kidney Research Scientist Core Education and National Training Program, Canada.

Background: Acute kidney injury (AKI) is a complex and heterogeneous clinical syndrome with limited effective treatment options. Therefore, a coherent research structure considering AKI pathophysiology, treatment, translation, and implementation is critical to advancing patient care in this area.

Purpose Of Review: In this narrative review, we discuss novel therapies for AKI from their journey from bench to bedside to population and focus on roadblocks and opportunities to their successful implementation. Read More

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http://dx.doi.org/10.1177/2054358119880519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787878PMC
October 2019
1 Read