793 results match your criteria Canadian journal of diabetes[Journal]


Beginning a Diabetes Quality Improvement Project.

Can J Diabetes 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology, St. Michael's Hospital, Toronto, Ontario, Canada.

There is a large evidence-to-clinical practice gap in diabetes care. Application of quality improvement (QI) strategies can be used to improve gaps in care delivery. In this first of 3 articles in the diabetes QI primer series, we introduce the steps required to plan a QI project by using a case example for improving foot screening of people with diabetes. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.02.003DOI Listing
February 2019
1 Read

Implementing Change Ideas, Interpreting Data and Sustaining Change in a Quality Improvement Project.

Can J Diabetes 2019 Feb 27. Epub 2019 Feb 27.

Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

This article is the third and final installment in our diabetes quality improvement primer series. It summarizes how to interpret real-time data with run charts and highlights 4 key rules that can be applied to understand whether improvement is statistically significant. We also review the importance of outlining a family of measures, including outcome, process and balancing measures. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.02.007DOI Listing
February 2019

Enhancing Health Surveillance: Validation of a Novel Electronic Medical Records-Based Definition of Cases of Pediatric Type 1 and Type 2 Diabetes Mellitus.

Can J Diabetes 2019 Feb 18. Epub 2019 Feb 18.

Department of Family Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Objectives: To compose and validate an electronic medical records-based case definition for pediatric diabetes in primary care.

Methods: Data from the electronic medical records of 221 primary care providers participating in the Manitoba Primary Care Research Network were extracted from April 1, 1998, to March 31, 2015. We assessed agreement among the 3 case definitions of pediatric diabetes and compared the performance of each with the clinical database of the Manitoba Diabetes Education Resource for Children and Adolescents. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.02.005DOI Listing
February 2019

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.

Can J Diabetes 2019 Jan 23. Epub 2019 Jan 23.

Inflammation Research Network, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; Department of Physiology & Pharmacology, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada; Libin Cardiovascular Institute of Alberta, Alberta Health Service and University of Calgary, Calgary, Alberta, Canada; Department of Medicine, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada. Electronic address:

This overview deals with mechanisms whereby hyperglycemia-induced oxidative stress compromises vascular endothelial function and provides a background for a recently published study illustrating the beneficial impact of endothelial sodium-glucose cotransporter 2 (SGLT2) inhibitors in attenuating hyperglycemia-induced vascular dysfunction in vitro. The data provide new insight that can possibly lead to improved drug therapy for people with type 2 diabetes. The working hypotheses that underpinned the experiments performed are provided, along with the findings of the study. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.01.005DOI Listing
January 2019
1 Read

Self-Monitoring of Blood Glucose: A Complementary Method Beyond the Oral Glucose Tolerance Test to Identify Hyperglycemia During Pregnancy.

Can J Diabetes 2019 Feb 18. Epub 2019 Feb 18.

Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Endocrine Division, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

Objectives: To compare: 1) 75 g oral glucose tolerance test (OGTT) and self-monitoring of blood glucose (SMBG) in identifying gestational diabetes mellitus (GDM) and other hyperglycemic statuses in pregnant women; 2) pregnancy outcomes according to glycemic status; and 3) participants' opinions regarding both methods.

Methods: A prospective study in women with a 50 g glucose load test ≥7.2 mmol/L at 24 to 28 weeks' gestation and singleton pregnancy. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.02.004DOI Listing
February 2019
4 Reads

Pharmacologic and Nonpharmacologic Therapies for the Gut Microbiota in Type 2 Diabetes.

Authors:
Robert Caesar

Can J Diabetes 2019 Apr 31;43(3):224-231. Epub 2019 Jan 31.

The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address:

The gut microbiota is an important regulator of host metabolism. Metagenome analyses have demonstrated that the gut microbiota differs between patients with type 2 diabetes and healthy subjects, and several studies have shown that impaired glucose metabolism is associated with decreased levels of butyrate-producing bacteria. Gut microbiota-produced metabolites, such as short-chain fatty acids, amino acid derivatives and secondary bile acids, participate in metabolic and immunologic processes and, hence, pose putative links between the gut microbiota and glucose homeostasis. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.01.007DOI Listing
April 2019
3 Reads

Response to the Letter to the Editor From Dr. Boudreau et al, "Validation of a Stepwise Approach Using Glycated Hemoglobin Levels to Reduce the Number of Required Oral Glucose Tolerance Tests to Screen for Cystic Fibrosis-Related Diabetes in Adults".

Authors:
Julie A Gilmour

Can J Diabetes 2019 Apr 20;43(3):163. Epub 2019 Feb 20.

Division of Endocrinology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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April 2019
2 Reads

Canada's New Healthy Eating Strategy: Implications for Healthcare Professionals and a Call to Action.

Can J Diabetes 2019 Apr 15;43(3):155-160. Epub 2019 Mar 15.

Department of Family and Emergency Medicine, University of Montreal, Montreal, Quebec; Centre de Recherche CHUM, Montreal, Quebec.

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Associations of Serum S100B and S100P with the Presence and Classification of Diabetic Peripheral Neuropathy in Adults With Type 2 Diabetes: A Case-Cohort Study.

Can J Diabetes 2019 Jan 11. Epub 2019 Jan 11.

Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Novel biomarkers of diabetic peripheral neuropathy provide potentially useful information for early identification and treatment of diabetic neuropathy, ultimately serving to reduce the burden of disease. This study was designed to investigate the potential associations of serum S100B and S100P (calcium-modulated proteins) with the presence and classification of diabetic peripheral neuropathy in adults with type 2 diabetes.

Methods: In a case-cohort setting, the data of 44 participants diagnosed with diabetic peripheral neuropathy, 44 control participants with type 2 diabetes but free of peripheral neuropathy and 87 healthy control individuals were collected and analyzed. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.01.003DOI Listing
January 2019
1 Read

Fast-Acting Insulin Aspart and the Need for New Mealtime Insulin Analogues in Adults With Type 1 and Type 2 Diabetes: A Canadian Perspective.

Can J Diabetes 2019 Jan 24. Epub 2019 Jan 24.

Division of Endocrinology and Metabolism, Western University, London, Ontario, Canada.

Limiting postprandial glucose (PPG) excursions is an important aspect of overall glycemic control. Rapid-acting insulin analogues (RAIAs) aim to mimic the physiologic action of endogenous insulin observed in individuals without diabetes and prevent excessive PPG excursions. However, many people with type 1 diabetes and type 2 diabetes treated with RAIAs do not achieve glycated hemoglobin (A1C) targets, and there is an unmet need for further improvements in PPG control. Read More

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January 2019

Risk Factors for Recurrent Diabetic Ketoacidosis in Adults With Type 1 Diabetes.

Can J Diabetes 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Université Laval, Ferdinand Vandry Pavilion, Quebec City, Québec, Canada. Electronic address:

Objectives: Identification of risk factors for recurrent diabetic ketoacidosis (DKA) in patients with type 1 diabetes could help target those at high risk so as to implement preventive measures. The main objective of this study was to identify factors associated with recurrent DKA in adult Canadian patients with type 1 diabetes.

Methods: This is a retrospective cohort study of adult patients who had a diagnosis of type 1 diabetes for at least 1 year and who were hospitalized for an isolated or recurrent DKA episode between January 2007 and January 2017 in 5 Québec City tertiary care hospitals. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.01.008DOI Listing
January 2019
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Heat-Shock Protein 70-Mediated Heat Preconditioning Attenuates Hepatic Carbohydrate and Oxidative Disturbances in Rats with Type 1 Diabetes.

Can J Diabetes 2019 Jan 11. Epub 2019 Jan 11.

Department of Experimental Physiology and Biochemistry, Institute of Biology, Faculty of Natural Sciences and Mathematics, University of Saints Cyril and Methodius, Skopje, Republic of Macedonia. Electronic address:

Objectives: Heat preconditioning and heat-shock protein (HSP) synthesis have significant cytoprotective effects against the development of cellular injury caused by the application of a subsequent stressor, which were found to depend on the time period between the stressors. We aimed to determine the most efficient recovery time (6 h or 24 h) following heat-stress exposure and prior application of diabetic streptozotocin (STZ) on the moderation of carbohydrate and oxidative metabolic disturbances caused by diabetes.

Methods: Experiment animals (Wistar rats) were exposed to acute heat stress at 41±1°C for 45 min, followed by 6-h or 24-h recovery times at room temperature before sacrifice or STZ administration. Read More

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January 2019
1 Read

Risk Factors for Adverse Outcomes in Adult and Pediatric Patients With Hyperglycemia Presenting to the Emergency Department: A Systematic Review.

Can J Diabetes 2018 Dec 6. Epub 2018 Dec 6.

Western University, London, Ontario, Canada; London Health Sciences Centre, London, Ontario, Canada; St. Joseph's Healthcare London, London, Ontario, Canada.

Hyperglycemia is a significant cause of morbidity and mortality, often resulting in adverse outcomes. This review aimed to identify predictors of adverse outcomes, such as repeated hospital visits, hospitalization or death, in patients presenting to the emergency department (ED) with hyperglycemia. Electronic searches of Medline and EMBASE were conducted for studies in English of patients presenting to the ED with hyperglycemia. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.008DOI Listing
December 2018
1 Read

Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertensive Patients With Type 2 Diabetes Mellitus.

Authors:
Tomoyuki Kawada

Can J Diabetes 2019 Jan 11. Epub 2019 Jan 11.

Department of Hygiene and Public Health Nippon Medical School Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jcjd.2019.01.001DOI Listing
January 2019

Diabetes and Frailty: Revisiting the Converging Conditions.

Authors:
Diana Sherifali

Can J Diabetes 2019 Mar;43(2):81

McMaster University, Hamilton, Ontario, Canada. Electronic address:

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Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes.

Can J Diabetes 2018 Dec 13. Epub 2018 Dec 13.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada; Alliance for Canadian Health Outcomes Research in Diabetes, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: Healthy user bias, whereby health-seeking patients are more likely to initiate preventive therapies and engage in healthy lifestyle behaviours, is well known in observational studies, particularly with statins. However, its influence in studies of oral antihyperglycemic therapies is unknown. We sought to explore the healthy user effects in metformin users vs. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.12.001DOI Listing
December 2018

Implementation and Evaluation of a Diabetic Ketoacidosis Order Set in Pediatric Type 1 Diabetes at a Tertiary Care Hospital: A Quality-Improvement Initiative.

Can J Diabetes 2018 Dec 26. Epub 2018 Dec 26.

Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Royal University Hospital, Saskatoon, Saskatchewan, Canada. Electronic address:

Objectives: Despite published clinical practice guidelines in pediatrics for the use of a standardized diabetic ketoacidosis (DKA) protocol, our centre lacked an accepted, evidence-informed protocol for pediatric DKA management. Our primary aim was to attain broad clinical uptake of a DKA order set. Secondary aims included improved standard-of-care DKA management principles regarding fluid, potassium and dextrose administration. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.12.005DOI Listing
December 2018
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Transition to Adult Diabetes Care: A Description of Practice in the Ontario Pediatric Diabetes Network.

Can J Diabetes 2018 Nov 15. Epub 2018 Nov 15.

Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objectives: Individuals living with diabetes often experience gaps in care, poor experiences and acute complications when they transfer from pediatric to adult care. We aimed to describe the structure of diabetes transition care in Ontario and to explore perceptions of barriers to optimal outcomes.

Methods: We conducted a cross-sectional descriptive study of 35 centres in the Pediatric Diabetes Network in Ontario between April and June 2017. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.10.007DOI Listing
November 2018

Evaluation of a Diabetic Ketoacidosis Order Set in Adults With Type 1 and Type 2 Diabetes at a Tertiary Academic Medical Centre: A Retrospective Chart Audit.

Can J Diabetes 2018 Nov 17. Epub 2018 Nov 17.

Department of Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address:

Objective: To assess safety and efficacy compared to a historical cohort. Clinical practice guidelines recommend that patients with diabetic ketoacidosis (DKA) be treated with a standardized protocol. We created a multifaceted order set to promote best-practice management of DKA. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.004DOI Listing
November 2018
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Validation of a Stepwise Approach Using Glycated Hemoglobin Levels to Reduce the Number of Required Oral Glucose Tolerance Tests to Screen for Cystic Fibrosis-Related Diabetes in Adults.

Can J Diabetes 2019 Apr 23;43(3):161-162. Epub 2018 Nov 23.

Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada; Université de Montréal, Départements de nutrition, Faculté de Médecine, Montréal, Québec, Canada; Cystic Fibrosis Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.jcjd.2018.11.005DOI Listing
April 2019
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What is the Real Usefulness of Glycated Hemoglobin Levels for Diabetes Screening in Patients With Cystic Fibrosis?

Can J Diabetes 2019 Feb;43(1):1-2

Cystic Fibrosis Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada; Université de Montréal, Départements de nutrition, Faculté de Médecine, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2018.11.001DOI Listing
February 2019
1 Read

The Concept of Sleep Ability and its Effect on Diabetes Control in Adults With Type 2 Diabetes.

Can J Diabetes 2018 Dec 6. Epub 2018 Dec 6.

Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kodatsuno, Kanazawa, Ishikawa, Japan.

Objectives: Few published studies have examined the effects of various components of sleep on the control of type 2 diabetes. This study aimed to construct a concept of sleep ability and examine its effect on diabetes control in adults with type 2 diabetes.

Methods: Participants were 37 outpatients, 41 to 73 years of age, who had type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.007DOI Listing
December 2018
1 Read

Effects of Pay-for-Performance for Primary Care Physicians on Preventable Diabetes-Related Hospitalization Costs among Adults in New Brunswick, Canada: A Quasiexperimental Evaluation.

Can J Diabetes 2018 Nov 24. Epub 2018 Nov 24.

Government of New Brunswick, Department of Health, Fredericton, New Brunswick, Canada.

Objectives: In New Brunswick, Canada, 13.6% of the population 35 years of age and older is living with type 1 or type 2 diabetes mellitus. To address public health and clinical challenges, pay-for-performance (P4P) for family physicians was introduced in 2010 to enable comprehensive diabetes management. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.006DOI Listing
November 2018
8 Reads

Acute Management of Diabetic Ketoacidosis in Adults at 3 Teaching Hospitals in Canada: A Multicentre, Retrospective Cohort Study.

Can J Diabetes 2018 Nov 17. Epub 2018 Nov 17.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: Diabetic ketoacidosis (DKA) is a common acute complication of diabetes mellitus and is associated with significant morbidity and mortality. There is currently a paucity of data concerning the Canadian experience with DKA. We aimed to characterize the acute management and course of DKA at several Canadian hospitals. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.11.003DOI Listing
November 2018
2 Reads

Association of Depressive Symptoms and Diabetes Distress With Severe Hypoglycemia in Adults With Type 2 Diabetes.

Can J Diabetes 2018 Nov 14. Epub 2018 Nov 14.

Alliance for Canadian Health Outcomes Research in Diabetes, School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To examine the association of depressive symptoms (DS) and diabetes-related distress (DD) with severe hypoglycemia (SH) in adults with type 2 diabetes.

Methods: Baseline data from a cohort study of adults with type 2 diabetes (N=2,040) were used. The Patient Health Questionnaire 8-items and Problem Areas in Diabetes 5-items questionnaires were used to assess DS and DD, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14992671173041
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http://dx.doi.org/10.1016/j.jcjd.2018.11.002DOI Listing
November 2018
11 Reads

The Diabetes Health Coaching Randomized Controlled Trial: Rationale, Design and Baseline Characteristics of Adults Living With Type 2 Diabetes.

Can J Diabetes 2018 Oct 17. Epub 2018 Oct 17.

Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; McMaster Evidence Review and Synthesis Team, McMaster University, Hamilton, Ontario, Canada.

Objectives: The Diabetes Health Coaching Trial was a single-blind, randomized controlled trial designed to evaluate the effect of a 1-year telephone-based diabetes health-coaching intervention for community-dwelling adults living with type 2 diabetes mellitus. It concerned glycated hemoglobin levels, self-care behaviours and cost-effectiveness. The purpose of this article is to describe the rationale, design and participants' characteristics. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.10.004DOI Listing
October 2018
1 Read

Glycated Hemoglobin Level Goal Achievement in Adults With Type 2 Diabetes in Canada: Still Room for Improvement.

Can J Diabetes 2018 Nov 2. Epub 2018 Nov 2.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada.

Objectives: To describe the clinical histories and management of adults with type 2 diabetes who were not reaching their target glycated hemoglobin (A1C) levels and to identify barriers to achieving therapeutic goals.

Methods: Practice assessment surveys and practice audits were completed by 88 primary care physicians (PCPs) in the Diabetes Mellitus Assessment of Clinical managemenT In ONtario (DM-ACTION) program and by 56 diabetes specialists in the Diabetes Mellitus IMproving PAtient Care in our communiTies (DM-IMPACT) program. The DM-ACTION audit analyzed data from 1,173 adults with A1C levels ≥7. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.10.005DOI Listing
November 2018
4 Reads

Elevated Carbohydrate Response Element-Binding Protein Beta (ChREBPβ) and Thioredoxin Interacting Protein (TXNIP) Levels in Human Adipocytes Differentiated in High Glucose Concentrations.

Can J Diabetes 2019 Apr 9;43(3):215-220. Epub 2018 Oct 9.

Chronic Disease Program, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Objectives: Obesity and type 2 diabetes often coexist. The effect of hyperglycemia on adipose tissue is, therefore, of interest. Although studies have shown that high glucose (HG) concentrations do not inhibit adipocyte differentiation, the resulting adipocyte phenotype has not been investigated. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.09.009DOI Listing

Prevalence of Known Risk Factors for Type 2 Diabetes Mellitus in Multiethnic Urban Youth in Edmonton: Findings From the WHY ACT NOW Project.

Can J Diabetes 2019 Apr 9;43(3):207-214. Epub 2018 Oct 9.

Indigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: The Canadian Diabetes Risk Assessment Questionnaire (CANRISK) is a validated, evidence-based, self-administered tool to assess the risk for type 2 diabetes mellitus in multiethnic Canadian adults. Identifying individuals at high risk for type 2 diabetes allows early intervention that improves modifiable risk factors. This study examined the risk factors for type 2 diabetes in multiethnic urban youth in Edmonton, Alberta. Read More

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April 2019
12 Reads

Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Can J Diabetes 2019 Apr 16;43(3):179-185.e1. Epub 2018 Aug 16.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

Objectives: To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending.

Methods: We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January 1, 2010, to December 31, 2015, using data from IQVIA (Durham, North Carolina, United States). Analysis was stratified according to insulin type, payer and province. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.08.190DOI Listing
April 2019
1 Read

Tailoring Diabetes Education to Meet the Needs of Adults With Type 2 Diabetes and Mental Illness: Client and Health-Care Provider Perspectives From an Exploratory Pilot Study.

Can J Diabetes 2018 Sep 24. Epub 2018 Sep 24.

Centre for Research on Employment and Workplace Health, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry and Behavioral Sciences, University of California-Davis, Davis, California, USA.

Objectives: People with mental illness are more likely to experience poorer outcomes with type 2 diabetes than the general population. Diabetes management can be improved when lifestyle-intervention content is tailored to the learning needs of individuals or groups. The purpose of this pilot study was to explore the perspectives of clients and providers involved with mental health care with regard to how diabetes education can effectively address the challenges that may be faced when people with mental illness engage in diabetes self-care behaviours. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.09.008DOI Listing
September 2018

Adjustment for Waist Circumference Reveals a U-Shaped Association Between Glycated Hemoglobin Levels and Body Mass Index in Young Adults.

Can J Diabetes 2019 Apr 21;43(3):201-206. Epub 2018 Sep 21.

School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Kanagawa, Japan; Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan. Electronic address:

Objectives: Body mass index (BMI) is used to assess adiposity worldwide. However, additional adjustment for waist circumference (WC), a surrogate marker of abdominal fat, may be capable of revealing a latent relationship between low body weight and glycated hemoglobin (A1C) concentration. Here, we investigated the relationship between A1C and BMI in young adults, adjusting for WC. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.09.007DOI Listing
April 2019
1 Read

The Relationship Between Increased Ratio of Visceral-to-Subcutaneous Fat Area and Renal Outcome in Chinese Adults With Type 2 Diabetes and Diabetic Kidney Disease.

Can J Diabetes 2018 Aug 25. Epub 2018 Aug 25.

Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Objective: Abdominal obesity is a risk factor of diabetes and hypertension. The aim of this study was to investigate the association between excessive abdominal fat and renal outcomes in patients with type 2 diabetes and diabetic kidney disease.

Methods: Thirty-five patients with type 2 diabetes and diabetic kidney disease who were followed up on for at least 1 year were enrolled. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.08.199DOI Listing
August 2018
1 Read

Endorsement of Diabetes Canada's Alternative Approach to Diagnosis of Gestational Diabetes.

Authors:
Jason M Kong

Can J Diabetes 2018 Dec 27;42(6):580. Epub 2018 Feb 27.

Division of Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jcjd.2018.02.007DOI Listing
December 2018

Diabetes and Dementia in the Elderly.

Can J Diabetes 2018 Dec;42(6):579

Department of Medicine, Vancouver Hospital and the University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2018.10.006DOI Listing
December 2018

A Comparison of Structured Education Programs for Pediatric Patients With Type 1 Diabetes: Multiple Daily Injection Therapy Delivered by Group Workshop vs. Self-Study Course.

Can J Diabetes 2018 Aug 9. Epub 2018 Aug 9.

Stollery Children's Hospital, Pediatric Diabetes Education Centre, Edmonton, Alberta, Canada; Division of Endocrinology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2018.08.060DOI Listing

Patient Assessment of Family Function, Glycemic Control and Quality of Life in Adult Patients With Type 2 Diabetes and Incipient Complications.

Can J Diabetes 2019 Apr 17;43(3):193-200. Epub 2018 Sep 17.

University College Copenhagen, Institute of Nursing, University College, Copenhagen, Denmark.

Objectives: Family affects the perception of diabetes self-management in patients with diabetes. Family-related questionnaires have been used to assess family function, but the Brief Family Assessment Measure (Brief FAM-III) has not been used previously in a diabetes population. We aimed to determine whether the family function is associated with glycated hemoglobin levels and quality of life as potential predictors of diabetes self-management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14992671183053
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http://dx.doi.org/10.1016/j.jcjd.2018.09.002DOI Listing
April 2019
2 Reads

Process Evaluation of the Diabetes Canada Guidelines Dissemination Strategy Using the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) Framework.

Can J Diabetes 2018 Aug 10. Epub 2018 Aug 10.

Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Ontario, Canada; Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objectives: Our purpose was to disseminate and implement the Diabetes Canada (formerly the Canadian Diabetes Association) 2013 Clinical Practice Guidelines and evaluate the impact of the dissemination and implementation strategy on process outcomes (reach, adoption, implementation and maintenance).

Methods: Our patient- and provider-directed strategy consisted of a guidelines website, electronic point-of-care decision-support tools, mobile applications, electronic medical record templates, laboratory prompts, continuing professional development modules, a communications campaign and printed education materials. We used the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework to assess process-level outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14992671183030
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http://dx.doi.org/10.1016/j.jcjd.2018.08.189DOI Listing
August 2018
11 Reads

Combination Therapy With Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Older Patients With Type 2 Diabetes: A Real-World Evidence Study.

Can J Diabetes 2019 Apr 8;43(3):186-192. Epub 2018 Sep 8.

Internal Medicine Department, Marina Baixa Hospital, Avda. Alcalde En Jaume Botella Mayor, s/n, La Vila Joiosa. Alicante, Spain.

Objectives: Scientific literature about the combination of glucagon-like peptide-1 receptor agonists (GLP-1ra) and sodium-glucose cotransporter 2 (SGLT2) inhibitors in older patients is scarce. We sought to assess the real-world efficacy and safety of SGLT2 inhibitors and GLP-1ra combination therapy in older patients (>65 years of age).

Methods: This was an observational, prospective, multicenter study based on clinical practice. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.09.001DOI Listing
April 2019
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Effect of Aerobic and Resistance Exercise on Glycemic Control in Adults With Type 1 Diabetes.

Can J Diabetes 2018 Aug 30. Epub 2018 Aug 30.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA. Electronic address:

Objectives: Physical exercise is recommended for individuals with type 1 diabetes, yet the effects of exercise on glycemic control are not well established. We evaluated the impact of different modes of exercise on glycemic control in people with type 1 diabetes.

Methods: In a 3-week randomized crossover trial, 10 adults with type 1 diabetes (4 men and 6 women, aged 33±6 years; duration of diabetes, 18±10 years; glycated hemoglobin level, 7. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.08.193DOI Listing
August 2018
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Development and Implementation of a Diabetic Ketoacidosis Protocol for Adults With Type 1 and Type 2 Diabetes at a Tertiary Care Multicampus Hospital.

Can J Diabetes 2018 Aug 16. Epub 2018 Aug 16.

The Ottawa Hospital, Ottawa, Ontario, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Objectives: Diabetic ketoacidosis (DKA) is associated with significant morbidity and mortality. Using standardized protocols for DKA management improves outcomes and is recommended in Diabetes Canada's clinical practice guidelines. Audits of DKA care at our institution revealed inconsistent management. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.08.192DOI Listing
August 2018
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In Vivo Type 2 Diabetes and Wound-Healing Effects of Antioxidant Gold Nanoparticles Synthesized Using the Insulin Plant Chamaecostus cuspidatus in Albino Rats.

Can J Diabetes 2019 Mar 6;43(2):82-89.e6. Epub 2018 Jun 6.

Environmental Nanotechnology Division, Sri Paramakalyani Centre for Environmental Sciences Manonmaniam Sundaranar University, Alwarkurichi, Tamilnadu, India.

Background: Gold nanoparticles are known for their many applications in the fields of therapeutics and diagnosis.

Methods: This article focuses mainly on the green method of synthesizing gold nanoparticles by using the leaf powder extract of the insulin plant Chamaecostus cuspidatus and on the characterization of developed plant-mediated synthesis of gold nanoparticles. Furthermore, we investigated the free-radical scavenging activity of green-synthesized gold nanoparticles. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.05.006DOI Listing
March 2019
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Insulin-Treated Diabetes and Driving: Legal Jeopardy and Consequences of Hypoglycemia.

Can J Diabetes 2019 Apr 6;43(3):221-223. Epub 2018 Sep 6.

Department of Medicine and Physiology, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

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Derivation and Validation of a Risk-Prediction Tool for Hypoglycemia in Hospitalized Adults With Diabetes: The Hypoglycemia During Hospitalization (HyDHo) Score.

Can J Diabetes 2018 Aug 10. Epub 2018 Aug 10.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Objectives: We sought to develop the Hypoglycemia During Hospitalization (HyDHo) scoring system, to predict the risk for hypoglycemia during hospitalization in patients with diabetes at the time of admission to a general medical unit.

Methods: We randomly selected 300 patients with diabetes who had been admitted to a medical inpatient unit at a teaching hospital. Hypoglycemia was defined as any point-of-care glucose test result ≤3. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.08.061DOI Listing
August 2018
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Storytelling to Support Disease Self-Management by Adults With Type 2 Diabetes.

Can J Diabetes 2018 Jun 22. Epub 2018 Jun 22.

Daphne Cockwell School of Nursing, Ryerson University, Toronto, Ontario, Canada.

Objectives: This pilot project aimed to examine the acceptability and feasibility of a group storytelling intervention to support self-management among adults living with type 2 diabetes.

Methods: Two waves of a single-arm storytelling intervention, consisting of 8 sessions at a community health centre, were delivered to 8 adults with type 2 diabetes. Diabetes educators facilitated each session, in which patients shared stories about diabetes-self-management topics of their choice. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.06.004DOI Listing
June 2018
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Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women.

Can J Diabetes 2019 Apr 2;43(3):173-178.e1. Epub 2018 Aug 2.

Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.07.003DOI Listing
April 2019
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Evaluation of the rs3088442 G>A SLC22A3 Gene Polymorphism and the Role of microRNA 147 in Groups of Adult Pakistani Populations With Type 2 Diabetes in Response to Metformin.

Can J Diabetes 2019 Mar 17;43(2):128-135.e3. Epub 2018 Jul 17.

Department of Bioinformatics & Biotechnology, International Islamic University, H-10, Islamabad, Pakistan. Electronic address:

Objectives: Type 2 diabetes is a complex genetic disorder, and a large number of genetic polymorphisms may be involved in its pathogenesis. Pharmacologically, type 2 diabetes can be treated with 9 different approved classes of drugs, but metformin is suggested as the first line of therapy, followed by sulfonylureas.

Methods: This was a case-control study consisting of 300 metformin responders and 300 metformin nonresponders in patients with type 2 diabetes and 300 healthy Pakistani subjects. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.07.001DOI Listing
March 2019
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The Health and Health Care of Adults With Type 1 And 2 Diabetes Across the Spectrum of Estimated Glomerular Filtration Rates.

Can J Diabetes 2019 Mar 21;43(2):105-114.e4. Epub 2018 Jun 21.

Institute for Clinical Evaluative Sciences, Ontario, Canada; Arthur Labatt Family School of Nursing, Western University, London, Ontario, Canada.

Objectives: Little is known about the health and health-care patterns of patients with diabetes according to their estimated glomerular filtration rates, especially within a publicly funded health-care system.

Methods: Using linked health-care databases in Ontario, Canada, we performed a population-based study of adults 50 years of age and older (mean age, 68 years) with prevalent diabetes on January 1, 2014. We categorized patients according to their levels of kidney function (estimated glomerular filtration rate ≥90, 60 to 89, 30 to 59, 15 to 29 or <15 mL/min/1. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.06.005DOI Listing
March 2019
2 Reads