Search Our Scientific Publications & Authors

J Adolesc 2018 Dec 3;70:43-52. Epub 2018 Dec 3.

York University, 5022 TEL, 4700 Keele St., Toronto ON, M3J 1P3, Canada. Electronic address:

Introduction: This study examined romantic relationships among street-involved youth through the overlapping perspectives of resilience, attachment and social bonding. The main goal was to assess how youth understand their romantic attachment bonds as supporting or undermining resilience. While there are qualitative reports on how the social relationships of street-involved youth are linked to resilience, romantic relationships have yet to be differentiated with regard to resilience. Read More

Nurse Educ Today 2018 Nov 29;73:65-70. Epub 2018 Nov 29.

Department of Child Health, School of Medicine, University of Missouri, 430 Sinclair School of Nursing, University of Missouri, Columbia, MO 65211, United States of America. Electronic address:

Introduction: Academic institutions are under pressure to maintain a nearly flawless retention rate, while graduating successful students. The use of standardized admission tests to provide data driven decisions regarding applicant selection is common. The varying reliability and validity of current standardized tests inspired a large Canadian academic institution to use a faculty developed admission test for admission to its practical nursing (PN) program. Read More

Clin Neurophysiol 2018 Nov 26;130(1):111-121. Epub 2018 Nov 26.

Department of Linguistics and Languages, McMaster University, Togo Salmon Hall 513, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; ARiEAL Research Centre, McMaster University, L.R. Wilson Hall, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; School of Biomedical Engineering, McMaster University, ETB-406, 1280 Main St., West Hamilton, ON L8S 4K1, Canada; MaRS Centre, Vector Institute, Canada; McMaster University, Department of Psychology, Neuroscience and Behaviour, Canada. Electronic address:

Objective: Recent studies demonstrate that sports-related concussions can have negative consequences on long-term brain health. The goal of the present study was to determine whether retired Canadian Football League (CFL) athletes with a history of concussions exhibit alterations in neurocognitive functioning, along with changes in physical, social, and psychological health.

Methods: Our study compared nineteen retired CFL athletes' concussion histories to eighteen healthy age-matched controls with no history of concussion. Read More

Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. Electronic address:

For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, fermented soy milk, Tempeh and soy sauce. Read More

Aging Ment Health 2018 Dec 6:1-9. Epub 2018 Dec 6.

b Faculty of Health Sciences , Western University , London , Canada.

Objectives: The study used data from the Canadian Longitudinal Study on Aging to investigate the relationships among social support (measured as affectionate support, emotional/informational support, positive social interaction, tangible support), social participation and depression in caregivers and non-caregivers.

Method: Hierarchical multiple regression was used to investigate relationships among social support, social participation, and depression. Analyses of variance were used to examine differences in the means of social support, social participation, and depression between the two participant groups. Read More

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Manitoba, Food and Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown to alleviate these effects by upregulating antioxidant mechanisms in the brain. The liver is the first organ to receive enriched blood after placental transport; therefore, it could be negatively affected by EtOH, but no studies have assessed the effects of DHA on fetal liver. Read More

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

Department of Geography and Planning , Queen's University , Kingston , Ontario K7L 3N6 , Canada.

Legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and emerging perfluoroalkyl substances (PFASs) were measured in vegetation and soil samples collected at remote lakes in the Canadian High Arctic. Field studies were carried out in 2015 and 2016 to assess concentrations of POPs, study the relevant sorbing phases, and determine whether Arctic soils were sinks or sources of legacy POPs to the atmosphere and to neighboring lakes. The patterns of legacy POPs in vegetation and soils were dominated by low molecular weight PCB congeners along with OCPs, confirming the importance of long-range atmospheric transport. Read More

Personal Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology.

Extant research has supported a connection between socialization in childhood and difficulties regulating emotions. The biosocial theory of borderline personality disorder (BPD; Crowell, Beauchaine, & Linehan, 2009; Linehan, 1993) suggests that emotion dysregulation is a core mechanism underlying the extreme behaviors, mood instability, identity disturbance, and relationship instability observed in BPD. The present study investigated the impact of socialization factors related to emotions, parental autonomy support, parental psychological control, and childhood trauma on BPD features in a nonclinical young adult sample (N = 357). Read More

Haemophilia 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: The Patient Reported Outcomes, Burdens and Experiences (PROBE) study aims to develop and validate questionnaire for assessing health status in patients with haemophilia and participants without bleeding disorders.

Objective: To investigate the test-retest properties of the PROBE questionnaire.

Methods: The PROBE questionnaire covers four domains and is comprised of 29 questions. Read More

Stem Cells 2018 Dec 5. Epub 2018 Dec 5.

Canadian Blood Services, Centre for Innovation, Ottawa, Ontario, Canada.

Ex vivo expansion of hematopoietic stem cells (HSC) and progenitors may one day overcome the slow platelet engraftment kinetics associated with umbilical cord blood (UCB) transplantation. Serum-free medium conditioned with osteoblasts (i.e. Read More

Health Expect 2018 Dec 5. Epub 2018 Dec 5.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The published literature demands examples of health-care systems designed with the active engagement of patients to explore the application of this complex phenomenon in practice.

Methods: This case study explored how the voice of patients was incorporated into the process of redesigning an element of the health-care system, a centralized system for intake of referrals from primary care to rheumatologists for patients with suspected rheumatoid arthritis (RA)-centralized intake. The phenomenon of patient engagement using "patient and community engagement researchers" (PaCERs) in research and the process of redesigning centralized intake were selected as the case. Read More

J Neurovirol 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychiatry, 1E.1 WC Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB, T6G 2R7, Canada.

The measurement and determinants of HIV-associated neurocognitive disorders (HAND) are under intense debate. We used latent profile analysis (LPA) and machine learning to define neurocognitive performance profiles and identify their associated risk factors in HIV patients receiving antiretroviral therapy (ART). Neurocognitive performance was assessed by a multidomain neuropsychological test battery. Read More

Support Care Cancer 2018 Dec 5. Epub 2018 Dec 5.

Faculty of Medicine and Health Sciences, Université de Sherbrooke, Longueuil, QC, Canada.

Purpose: Although family caregivers (FCs) of older adults with cancer (OACs) provide invaluable assistance by fulfilling multiple tasks along the cancer trajectory, evidence suggests that their needs are poorly assessed, and there is a scarcity of supportive interventions that influence their well-being. Viewing these issues as opportunities for improvement, we conducted this qualitative study to understand FCs' needs and identify promising needs-focused interventions.

Methods: This descriptive interpretive qualitative study was conducted in Quebec, Canada, in a French Canadian Oncology Clinic. Read More

Heliyon 2018 Nov 27;4(11):e00970. Epub 2018 Nov 27.

Health Law Institute, University of Alberta Faculty of Law, Edmonton, Alberta, Canada.

Influenza vaccine uptake is less-than-ideal in many jurisdictions, including Canada. In this study we sought to assess news articles relating to influenza vaccination by major Canadian newspapers during a six-month period relatively congruent to the seasonal influenza outbreak for 2017-2018. We identified 116 unique articles published between August 16, 2017 and February 15, 2018, then developed and applied a coding frame to them. Read More

Ecol Evol 2018 Nov 9;8(22):11363-11367. Epub 2018 Oct 9.

Department of Paleobiology Smithsonian Institution, National Museum of Natural History District of Columbia Washington.

In response to DeSantis et al., we describe that the presence of phylogenetic signal in tooth wear dietary niche proxies is likely a result of the evolutionary process. We also address their concerns regarding enforcement of the use of phylogenetic comparative methods by editors of ecology and evolution journals. Read More

Eur Rev Aging Phys Act 2018 30;15:15. Epub 2018 Nov 30.

1School of Kinesiology and Health Science, York University, 116 Norman Bethune College, 4700 Keele St., Toronto, ON M3J 1P3 Canada.

Background: Identifying the optimal type and amount of activity for the maintenance of function in older adults has proved challenging. On the one hand, Masters Athletes have been proposed as the ideal model of successful aging but most of this research has focused on physical functioning. On the other hand, the importance of cognitive engagement has been emphasized, which may be more strongly related to activities such as playing chess. Read More

Clin Epidemiol 2018 8;10:1613-1626. Epub 2018 Nov 8.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background And Aims: Canada's large geographic area and low population density pose challenges in access to specialized health care for remote and rural residents. We compared health services use, surgical rate, and specialist gastroenterologist care in rural and urban inflammatory bowel disease (IBD) patients in Canada.

Methods: We used validated algorithms that were applied to population-based health administrative data to identify all people living with the following three Canadian provinces: Alberta, Manitoba, and Ontario (ON). Read More

Infect Drug Resist 2018 8;11:2211-2217. Epub 2018 Nov 8.

Department of Microbiology, Faculty of Dentistry and Oral Medicine, Future University, Cairo, Egypt.

Introduction: is a significant hospital-acquired pathogen, and many outbreaks of infection have been reported in neonates. We report a sudden breakout of harboring the and metallo-β-lactamase (MBL) genes that occurred from March to August 2015 in the neonatal intensive care unit of Cairo University Hospital, Cairo, Egypt.

Methods: During the study period, 40 nonduplicate clinical isolates of were collected from blood culture samples. Read More

Pediatrics 2018 Dec 5. Epub 2018 Dec 5.

Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants.

Methods: Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Read More

BMJ 2018 Dec 5;363:k4880. Epub 2018 Dec 5.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Cote Sainte-Catherine Road, H425.1, Montreal, QC, H3T 1E2, Canada

Objective: To determine whether use of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists are associated with an increased risk of cholangiocarcinoma in adults with type 2 diabetes.

Design: Population based cohort study.

Setting: General practices contributing data to the UK Clinical Practice Research Datalink. Read More

BMJ Open 2018 Dec 4;8(12):e025059. Epub 2018 Dec 4.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Introduction: Illicit opioid use has become a national crisis in Canada, with over 65 000 people seeking treatment for opioid use disorder (OUD) in Ontario and British Columbia alone. Medication-assisted treatment (MAT) is a common treatment for OUD. There is substantial variability in treatment outcomes used to evaluate effectiveness of MAT, making it difficult to establish clinically and scientifically relevant treatment effect. Read More

Syst Rev 2018 Dec 5;7(1):225. Epub 2018 Dec 5.

Division of Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada.

Background: Acute myocardial infarction (MI) remains one of the leading causes of death worldwide with no curative therapy available. Stem cell therapies have been gaining interest as a means to repair the cardiac tissue after MI and prevent the onset of heart failure. Many in vivo reports suggest that the use of stem cells is promising, yet clinical trials suggest that the cells fail to integrate into the native tissue, resulting in limited improvements in cardiac function and repair. Read More

BMC Public Health 2018 Dec 5;18(1):1344. Epub 2018 Dec 5.

Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, M5G 1V2, Canada.

Background: Emergencies and disasters impact population health. Despite the importance of upstream readiness, a persistent challenge for public health practitioners is defining what it means to be prepared. There is a knowledge gap in that existing frameworks lack consideration for complexity relevant to health systems and the emergency context. Read More

Can J Nurs Res 2018 Dec 5:844562118817079. Epub 2018 Dec 5.

1 Faculty of Health and Human Services, Vancouver Island University, Nanaimo, British Columbia, Canada.

Purpose: This study explores the impact of interplaying and often compounding factors and the resulting ability to thrive as a novice nurse. Novice nurse attrition rates continue to be high, compounding concerns of an impending nursing shortage. There is currently a lack of research that seeks to understand how the interplay of contextual factors impacts novice nurses' ability to manage the stressors endemic in the field. Read More

Int J Environ Res Public Health 2018 Dec 4;15(12). Epub 2018 Dec 4.

Institute for Work & Health, Toronto, ON M5G 2E9, Canada.

Employers are increasingly interested in offering workplace wellness programs in addition to occupational health and safety (OHS) activities to promote worker health, wellbeing, and productivity. Yet, there is a dearth of research on workplace factors that enable the implementation of OHS and wellness to inform the future integration of these activities in Canadian workplaces. This study explored workplace demographic factors associated with the co-implementation of OHS and wellness activities in a heterogenous sample of Canadian workplaces. Read More

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.

The objective of this study was to determine the effect of six chlorogenic acid (CGA) isomers known to be present in coffee and other plant foods on modulating the inflammatory response induced by pro-inflammatory cytokines in the Caco-2 human intestinal epithelial cell line. Compared to caffeoylquinic acids (CQA), dicaffeoylquinic acids (DiCQA) had significantly stronger ( < 0.05) capacities to reduce phosphorylation of one of mitogen-activated protein kinases (MAPK) cascades, namely p38. Read More

Neurobiol Aging 2018 Nov 5;75:25-37. Epub 2018 Nov 5.

Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address:

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in available transgenic mouse models. However, this new mouse model for AD is not fully characterized age-dependently with respect to behavioral and biochemical changes. Therefore, in the present study, we performed an age-dependent behavioral and biochemical characterization of this newly developed mouse model. Read More

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China; Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China; Key Laboratory of Reproductive and Stem Cell Engineering, Ministry of Health, Changsha, China. Electronic address:

Study Objective: To investigate the effectiveness of Tornado and Hilal (Cook Medical, Bloomington, Indiana, USA) hysteroscopic proximal tubal occlusion (HPTO) for hydrosalpinx (HX) treatment prior to in vitro fertilization (IVF) and embryo transfer (ET) in patients with dense pelvic adhesions or low ovarian reserve.

Design: Retrospective study of patients treated between May 2014 and May 2016 (Canadian Task Force classification III).

Setting: University-affiliated center. Read More

Clin Infect Dis 2018 Dec 3. Epub 2018 Dec 3.

Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, CA.

Background: Recent studies have demonstrated the possibility of negative associations between prior influenza vaccines and subsequent influenza vaccine effectiveness (VE), depending on season and strain. We investigated this association over 4 consecutive influenza seasons (2011/2012-2014/2015) in Canada.

Methods: Using a matched test-negative design, laboratory-confirmed influenza cases and matched test-negative controls admitted to hospitals were enrolled. Read More

J Trauma Acute Care Surg 2018 Nov 30. Epub 2018 Nov 30.

Royal Canadian Medical Service, Ottawa, ON, Canada.

Background: Junctional tourniquets have been incorporated into tactical combat casualty care for junctional vascular trauma. They apply external compression to stop blood flow in the groin and axilla.

Objectives: The primary outcome was effectiveness in achieving arterial occlusion. Read More

Blood Coagul Fibrinolysis 2018 Nov 29. Epub 2018 Nov 29.

Real Fundación Victoria Eugenia.

Prophylaxis entails long-term continuous intravenous administration of concentrates of the deficient factor with a view to preventing spontaneous bleeds and the development of hemophilic arthropathy. Initiation of prophylaxis at an early age and continuous uninterrupted factor administration in patients with hemophilia have been hailed as essential by such organizations.The most widely used prophylaxis regimens include the Swedish (Malmö), the Dutch and the Canadian protocols. Read More

Stem Cells Transl Med 2018 Dec 1. Epub 2018 Dec 1.

Axe Neurosciences, Research Center of the CHU de Quebec-CHUL, Quebec, Canada.

J Community Psychol 2019 Jan 12;47(1):7-20. Epub 2018 Jun 12.

University of Winnipeg.

In this study, we examine changes in the homeless-serving system in the context of a training and technical assistance initiative to scale up Housing First (HF) in 6 Canadian communities. Based on qualitative data from focus groups and individual interviews with key stakeholders (k = 7, n = 35) and field notes gathered over a 3-year period (n = 146), we found 2 main system changes: (a) changes in the capacity of the service delivery system at multiple levels of analysis (from individual to policy) to implement HF, and (b) changes in the coordination of parts of the service delivery system and collaboration among local stakeholders to enhance HF implementation. These changes were facilitated or constrained by the larger context of evidence, climate, policy, and funding. Read More

Mol Ecol 2018 Dec 2. Epub 2018 Dec 2.

Institut de Biologie Intégrative et des Systèmes, Université Laval, Québec, QC, G1V 0A6.

Chromosomal inversions have been implicated in facilitating adaptation in the face of high levels of gene flow, but whether chromosomal fusions also have similar potential remains poorly understood. Atlantic salmon are usually characterized by population structure at multiple spatial scales; however, this is not the case for tributaries of the Miramichi River in North America. To resolve genetic relationships between populations in this system and the potential for known chromosomal fusions to contribute to adaptation we genotyped 728 juvenile salmon using a 50K SNP array. Read More

Am J Transplant 2018 Dec 1. Epub 2018 Dec 1.

University of California at San Francisco, San Francisco, CA, USA.

A consensus conference on frailty in kidney, liver, heart and lung transplantation, sponsored by the American Society of Transplantation (AST) and endorsed by the American Society of Nephrology (ASN), the American Society of Transplant Surgeons (ASTS) and the Canadian Society of Transplantation (CST), took place on February 11, 2018 in Phoenix, Arizona. Input from the transplant community through scheduled conference calls enabled wide discussion of current concepts in frailty, exploration of best practices for frailty risk assessment of transplant candidates and for management after transplant, and development of ideas for future research. A current understanding of frailty was compiled by each of the solid organ groups and is presented in this paper. Read More

Brain Struct Funct 2018 Dec 1. Epub 2018 Dec 1.

Centre for Vision Research, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.

The dorsal anterior cingulate cortex (dACC) and lateral prefrontal cortex (lPFC) of the non-human primate show neural firing correlations and synchronize at theta and beta frequencies during the monitoring and shifting of attention. These functional interactions might be based on synaptic connectivity that is equally efficacious in both directions, but it might be that there are systematic asymmetries in connectivity consistent with reports of more effective inhibition within the dACC than lPFC, or with a preponderance of dACC projections synapsing onto inhibitory neurons in the lPFC. Here, we tested effective dACC-lPFC connectivity in awake monkeys and report systematic asymmetries in the temporal patterning and latencies of effective connectivity as measured using electrical microstimulation. Read More

Eur J Nucl Med Mol Imaging 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology and Nuclear Medicine, Université Laval, Quebec City, Canada.

Purpose: Peptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and undertreatment of the majority of patients. We conceived a personalized PRRT protocol in which the IA is adjusted to deliver a prescribed absorbed dose to the kidney, with the aim to safely increase tumour irradiation. Read More

Psychopharmacology (Berl) 2018 Nov 30. Epub 2018 Nov 30.

Cognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.

An understanding of how memory is acquired and how it can be modified in fear-related anxiety disorders, with the enhancement of failing memories on one side and a reduction or elimination of traumatic memories on the other, is a key unmet challenge in the fields of neuroscience and neuropsychiatry. The latter process depends on an important form of learning called fear extinction, where a previously acquired fear-related memory is decoupled from its ability to control behaviour through repeated non-reinforced exposure to the original fear-inducing cue. Although simple in description, fear extinction relies on a complex pattern of brain region and cell-type specific processes, some of which are unique to this form of learning and, for better or worse, contribute to the inherent instability of fear extinction memory. Read More

J Behav Health Serv Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada.

Visits to emergency departments (EDs) for pediatric mental health care have increased over the years. The likelihood of ED re-visit is greatest for older children; however, little is known about age-varying effects on ED visits/re-visits. This study used population-based administrative databases from Alberta, Canada, to investigate the association of predictors on mental health ED visit frequency by age for 27,947 children who presented at least once for mental health care from April 2002 to March 2011. Read More

J Occup Rehabil 2018 Nov 30. Epub 2018 Nov 30.

Partnership for Work, Health and Safety, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Purpose Research has shown that there are important sex and gender-based differences in the work disability duration of men and women. This research is often limited to single jurisdictions, using different outcome measures, and therefore has limited generalisability of findings. This study examined if differences between work disability of men and women differed by province and by duration of work disability. Read More

World J Nucl Med 2018 Oct-Dec;17(4):223-227

The Johns Hopkins Hospital, Baltimore, MD 21287, USA.

Our goal for this study was to evaluate the comprehensiveness of nuclear medicine (NM) residency websites from the USA and Canada. The authors searched all the existing NM residency programs as listed in the Fellowship and Residency Electronic Interactive Database and the Canadian Residency Matching Service. We analyzed each website for the presence or absence of 44 elements previously identified as important considerations for medical students applying to residency. Read More

PhytoKeys 2018 14(111):69-102. Epub 2018 Nov 14.

Research and Collections Division, Canadian Museum of Nature, P.O. Box 3443, Station D, Ottawa, Ontario K1P 6P4, Canada Canadian Museum of Nature Ottawa Canada.

is a small genus of annual grasses distributed from Egypt to western China. Phylogenetic analyses of plastid and nuclear ribosomal DNA show that species, together with the monotypic genus and a single species of (), are nested within the genus , in a clade that we accept as Poasubg.Pseudopoa. Read More

J Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

From the Sunnybrook Research Institute, Holland Bone and Joint Research Program, Toronto, Ontario; McGill University, Department of Epidemiology, Biostatistics and Occupational Health; Research Institute of the McGill University Health Centre, Department of Clinical Epidemiology, and Centre for Outcomes Research and Evaluation, Montreal, Quebec; ICES; University of Toronto, Institute of Health Policy, Management and Evaluation, Toronto; McMaster University, Department of Family Medicine, Hamilton; Southlake Regional Health Centre, Department of Medicine, Newmarket; Western University, Department of Epidemiology and Biostatistics; St. Joseph's Health Care, Department of Medicine, London; Mount Sinai Hospital, Department of Medicine, Toronto, Ontario, Canada. This analysis was supported by the Canadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research, which is funded by the Canadian Institutes of Health Research Drug Safety and Effectiveness Network (funding reference no. TD3-137716). JW was supported by fellowship awards from The Arthritis Society and the Canadian Institutes of Health Research (Banting) during the course of this work; SB holds a career award from the Fonds de la recherche en santé du Québec; MA is a James McGill Professor of Biostatistics at McGill University. This study was supported by the ICES, a nonprofit research corporation funded by the Ontario Ministry of Health and Long-Term Care. Parts of this material are based on data and/or information compiled and provided by the Canadian Institutes of Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed in the material are those of the authors and not necessarily those of CIHI. J. Widdifield, PhD, Sunnybrook Research Institute, Holland Bone and Joint Research Program, and McGill University, Department of Epidemiology, Biostatistics and Occupational Health, and Research Institute of the McGill University Health Centre, Department of Clinical Epidemiology, ICES, and University of Toronto, Institute of Health Policy, Management and Evaluation; M. Abrahamowicz, PhD, McGill University, Department of Epidemiology, Biostatistics and Occupational Health, and Research Institute of the McGill University Health Centre, Centre for Outcomes Research and Evaluation; J.M. Paterson, MSc, ICES, and University of Toronto, Institute of Health Policy, Management and Evaluation, and McMaster University, Department of Family Medicine; A. Huang, MSc, ICES; J.C. Thorne, MD, FRCPC, Southlake Regional Health Centre, Department of Medicine; J.E. Pope, MD, FRCPC, MPH, Western University, Department of Epidemiology and Biostatistics, and St. Joseph's Health Care, Department of Medicine; B. Kuriya, MD, FRCPC, SM, Mount Sinai Hospital, Department of Medicine; M.E. Beauchamp, PhD, Research Institute of the McGill University Health Centre, Centre for Outcomes Research and Evaluation; S. Bernatsky, MD, FRCPC, PhD, McGill University, Department of Epidemiology, Biostatistics and Occupational Health, and Research Institute of the McGill University Health Centre, Centre for Outcomes Research and Evaluation. Address correspondence J. Widdifield, Holland Bone and Joint Research Program, Sunnybrook Research Institute MG 352, 2075 Bayview Ave., Toronto, Ontario M4N 3M5, Canada. E-mail: Accepted for publication August 22, 2018.

Objective: We evaluated the associations between time-varying methotrexate (MTX) use and risk of cardiovascular events (CVE) in patients with rheumatoid arthritis (RA).

Methods: We studied an inception cohort of 23,994 patients with RA diagnosed after their 65th birthday. Multivariable Cox regression models were fit to evaluate the associations between time-varying MTX use, controlling for other risk factors, and time to CVE. Read More

Crit Care Nurse 2018 Dec;38(6):47-57

Vanessa M. Lobo develops workshops for clinicians and teaches in Health Organization Management at the Canadian University Dubai, Dubai, United Arab Emirates. Jenny Ploeg is a professor in the School of Nursing and associate member, Department of Health, Aging and Society, McMaster University, Hamilton, Ontario. She is scientific director of the Aging, Community and Health Research Unit, School of Nursing, McMaster University. Anita Fisher is an associate professor in the School of Nursing, Faculty of Health Science at McMaster University. Gladys Peachey is retired from the faculty of Nursing at McMaster University. Noori Akhtar-Danesh is an associate professor of biostatistics, School of Nursing, McMaster University.

Background: Around the world, registered nurses are working increasing amounts of overtime. This is particularly true in critical care environments, which experience unpredictable fluctuations in patient volume and acuity, combined with a need for more specialized nurses.

Objective: To explore critical care nurses' reasons for working or not working overtime. Read More

J Dent Educ 2018 Dec;82(12):1296-1304

Caroline Nguyen Ngoc, DMS, MS, is Assistant Professor, Department of Restorative Dentistry, Faculté de Médecine Dentaire, Université de Montréal; and Terry E. Donovan, DDS, is Professor and Section Head for Biomaterial, Department of Operative Dentistry, University of North Carolina at Chapel Hill School of Dentistry.

Dental erosion (DE) is a well-accepted multifactorial form of tooth wear involving acids. Due to its irreversible nature, recognizing the early signs is important to develop appropriate preventive strategies. However, its place in dental curricula remains unclear. Read More

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):561-567

Michael G. DeGroote School of Medicine, Department of Medicine and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

In this report, we will review the various clinical and laboratory approaches to diagnosing immune thrombocytopenia (ITP), with a focus on its laboratory diagnosis. We will also summarize the results from a number of laboratories that have applied techniques to detect anti-platelet autoantibodies as diagnostic tests for ITP. Although there is considerable variability in methods among laboratories, there is general agreement that platelet autoantibody testing has a high specificity but low sensitivity. Read More

J Pain 2018 Nov 29. Epub 2018 Nov 29.

International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Centre for Clinical Epidemiology and Evaluations, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. Electronic address:

Recent temporal trends in the population prevalence of chronic pain in Canada on a national and provincial level are unknown. Five cycles of the Canadian Community Health Survey (CCHS) (2000/01, 2007/08, 2009/10, 2011/12 and 2013/14) were used to derive population-based estimates of self-reported prevalence of chronic pain. Sensitivity analyses examined chronic pain prevalence among those reporting no other chronic health conditions. Read More

Health Place 2018 Nov 29. Epub 2018 Nov 29.

Ray-Cam Cooperative Centre, 920 East Hastings, Vancouver, British Columbia, Canada V6A 3T1. Electronic address: