1,348 results match your criteria Canadian Respiratory Journal[Journal]


Distance to Specialist Medical Care and Diagnosis of Obstructive Sleep Apnea in Rural Saskatchewan.

Can Respir J 2019 14;2019:1683124. Epub 2019 Jan 14.

Department of Public Health Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.

Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing condition. Patients with OSA symptoms are often not diagnosed clinically, which is a concern, given the health and safety risks associated with unmanaged OSA. The availability of fewer practicing medical specialists combined with longer travel distances to access health care services results in barriers to diagnosis and treatment in rural communities. Read More

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http://dx.doi.org/10.1155/2019/1683124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348862PMC
January 2019
1 Read

Current Practice in the Management of Pulmonary Nodules Detected on Computed Tomography Chest Scans.

Can Respir J 2019 6;2019:9719067. Epub 2019 Jan 6.

Division of Respiratory Medicine, University of British Columbia, Vancouver, Canada.

Lung cancer is associated with high mortality. It can present as one or more pulmonary nodules identified on computed tomography (CT) chest scans. The National Lung Screening Trial has shown that the use of low-dose CT chest screening can reduce deaths due to lung cancer. Read More

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http://dx.doi.org/10.1155/2019/9719067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339749PMC
January 2019

Errors in Aerosol Inhaler Use and Their Effects on Maternal and Fetal Outcomes among Pregnant Asthmatic Women (Subanalysis from QAKCOP Study).

Can Respir J 2018 18;2018:7649629. Epub 2018 Dec 18.

Gynecologist and Obstetrician, St. Josefs Hospital, Wiesbaden, Germany.

Data on inhaler technique and its effects on maternal and fetal outcomes during pregnancy are seldom reported. The primary objective of this study was to evaluate inhaler technique and identify errors in inhaler use among pregnant women with asthma. Secondary objectives were to identify factors associated with poor inhaler technique and study the association between inhaler technique and maternal and fetal outcomes. Read More

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https://www.hindawi.com/journals/crj/2018/7649629/
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http://dx.doi.org/10.1155/2018/7649629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312601PMC
December 2018
10 Reads

Cardiorespiratory Responses to Glittre ADL Test in Bronchiectasis: A Cross-Sectional Study.

Can Respir J 2018 17;2018:7470387. Epub 2018 Dec 17.

Associate Professor, Department of Pulmonary Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Mangaluru 575004, India.

Background: Bronchiectasis is a chronic respiratory condition characterised by chronic sputum production, fatigue, and dyspnoea. These symptoms will lead to reduced exercise capacity and a reduced ability to carry out activities of daily living. Glittre ADL test is a valid and reliable test which evaluates the activities of daily living. Read More

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http://dx.doi.org/10.1155/2018/7470387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311838PMC
December 2018
2 Reads

Cardiac Magnetic Resonance Imaging for Diagnosis of Cardiac Sarcoidosis: A Meta-Analysis.

Can Respir J 2018 17;2018:7457369. Epub 2018 Dec 17.

Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Cardiac magnetic resonance imaging (CMR) is an effective technique for the diagnosis of cardiac sarcoidosis (CS). The efficacy of CMR versus the Japanese Ministry of Health and Welfare (JMHW) guidelines considered as standard criterion for the diagnosis of CS remains to be elucidated.

Methods: In this systematic review and meta-analysis, we aimed at assessing the diagnostic accuracy of CMR in cardiac sarcoidosis. Read More

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https://www.hindawi.com/journals/crj/2018/7457369/
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http://dx.doi.org/10.1155/2018/7457369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311842PMC
December 2018
9 Reads

Daily Objective Physical Activity and Sedentary Time in Adults with COPD Using Spirometry Data from Canadian Measures Health Survey.

Can Respir J 2018 2;2018:9107435. Epub 2018 Dec 2.

Department of Social and Preventive Medicine, School of Public Health, University of Montréal, Montréal, QC, Canada.

Chronic obstructive pulmonary disease (COPD) is expected to be the third leading cause of premature death and disability in Canada and around the world by the year 2020. The study aims to compare objective physical activity (PA) and sedentary time in a population-based sample of adults with chronic obstructive pulmonary disease (COPD) and compare a group, and to investigate whether these behaviors differ according to COPD severity. From the 2007-2013 Canadian Health Measures Survey dataset, accelerometer and prebronchodilator spirometry data were available for 6441 participants, aged 35 to 79. Read More

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http://dx.doi.org/10.1155/2018/9107435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304807PMC
December 2018
2 Reads

Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia.

Can Respir J 2018 22;2018:7260178. Epub 2018 Nov 22.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP).

Materials And Methods: Serum HO-1 levels of newly diagnosed or untreated patients with IP were measured at hospitalization. Read More

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http://dx.doi.org/10.1155/2018/7260178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282126PMC
November 2018
1 Read

Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.

Can Respir J 2018 18;2018:1206217. Epub 2018 Nov 18.

University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.

Obstructive sleep apnea (OSA) causes recurrent apneas due to upper respiratory tract collapse, leading to sympathetic nervous system hyperactivation and increased cardiovascular risk. Moderate and severe forms of obstructive sleep apnea are associated with increased atrial volumes and affect left ventricular diastolic and then systolic function. Right ventricular ejection fraction can be accurately assessed via three-dimensional echocardiography, while bidimensional imaging can only provide a set of surrogate parameters to characterize systolic function (tricuspid annulus plane systolic excursion, right ventricular fractional area change, and lateral S'). Read More

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http://dx.doi.org/10.1155/2018/1206217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276396PMC
November 2018
3 Reads

Cost Effectiveness of Bosentan for Pulmonary Arterial Hypertension: A Systematic Review.

Can Respir J 2018 18;2018:1015239. Epub 2018 Nov 18.

Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objectives: Although many studies have reported on the cost-effectiveness of bosentan for treating pulmonary arterial hypertension (PAH), a systematic review of economic evaluations of bosentan is currently lacking. Objective evaluation of current pharmacoeconomic evidence can assist decision makers in determining the appropriate place in therapy of a new medication.

Methods: Systematic literature searches were conducted in English-language databases (MEDLINE, EMBASE, EconLit databases, and the Cochrane Library) and Chinese-language databases (China National Knowledge Infrastructure, WanFang Data, and Chongqing VIP) to identify studies assessing the cost-effectiveness of bosentan for PAH treatments. Read More

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http://dx.doi.org/10.1155/2018/1015239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276424PMC
November 2018
8 Reads

Tongue Function: An Underrecognized Component in the Treatment of Obstructive Sleep Apnea with Mandibular Repositioning Appliance.

Can Respir J 2018 6;2018:2157974. Epub 2018 Nov 6.

Department of Orthodontics, Case Western Reserve University, Cleveland, USA.

Obstructive sleep apnea (OSA) is a common but still underrecognized disorder. A mandibular repositioning appliance (MRA) is used to treat OSA by advancing the mandible and thereby reducing the collapsibility of the upper airway. It has been found that an MRA increases the volume of the upper airway, especially the velopharyngeal area, in OSA patients. Read More

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http://dx.doi.org/10.1155/2018/2157974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247694PMC
November 2018
2 Reads
1.663 Impact Factor

Sonographic Indicators for Treatment Choice and Follow-Up in Patients with Pleural Effusion.

Can Respir J 2018 30;2018:9761583. Epub 2018 Oct 30.

Faculty of Medicine, University of Belgrade, Serbia.

Aim: The aim of this study was to evaluate the role of thoracic sonography in treatment of pleural effusions and to identify sonographic indicators for surgical intervention.

Materials And Methods: This study included 378 patients with pleural effusions. US characteristics of effusions as the echo structure and pleural thickening were analyzed. Read More

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http://dx.doi.org/10.1155/2018/9761583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232814PMC
October 2018
2 Reads

Variation of Risk Factors for Cause-Specific Reintubation: A Preliminary Study.

Can Respir J 2018 28;2018:3654251. Epub 2018 Oct 28.

Department of Critical and Intensive Medicine, Shiga University of Medical Science, Seta-tsukinowa-cho, Otsu-shi, Shiga 527-8505, Japan.

Unexpected reintubation may occur, even if the risk factors are considered and a spontaneous breathing trial is successful. Reintubation is thought to be caused by various factors. Several studies have investigated the risk factors of reintubation, but most did not classify reintubation by cause. Read More

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https://www.hindawi.com/journals/crj/2018/3654251/
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http://dx.doi.org/10.1155/2018/3654251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230426PMC
October 2018
9 Reads

Intrabullous Adhesion Pexia (IBAP) by Percutaneous Pulmonary Bulla Centesis: An Alternative for the Surgical Treatment of Giant Pulmonary Bulla (GPB).

Can Respir J 2018 23;2018:5806834. Epub 2018 Oct 23.

Department of Respiratory and Critical Care Medicine, Donghai Hospital, Ningbo University, No. 377 Zhongshan East Road, Ningbo 315040, China.

Background And Objective: Most patients with giant pulmonary bulla (GPB) are treated by surgery; however, there is a subset for whom surgery is not a viable option, such as those with contraindications, or those unwilling to undergo operation. Therefore, an alternative minimally invasive method is desired for this subpopulation. The aim of this study was to explore an alternative procedure for treating GPB. Read More

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https://www.hindawi.com/journals/crj/2018/5806834/
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http://dx.doi.org/10.1155/2018/5806834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218743PMC
October 2018
10 Reads

Effects of Comorbidities on Asthma Hospitalization and Mortality Rates: A Systematic Review.

Can Respir J 2018 1;2018:6460379. Epub 2018 Oct 1.

Librarian II, Eastern Health, Department of Research, St. John's, Canada.

Background: Recent studies have shown that patients diagnosed with asthma who have other chronic comorbidities have severely worse medical outcomes. However, the number of available published studies in this field is lacking. The aim of this study was to determine the effects of comorbidities in asthmatic patients based on hospitalization and mortality rates. Read More

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https://www.hindawi.com/journals/crj/2018/6460379/
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http://dx.doi.org/10.1155/2018/6460379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191953PMC
October 2018
16 Reads

Lung Ultrasound Is Accurate for the Diagnosis of High-Altitude Pulmonary Edema: A Prospective Study.

Can Respir J 2018 1;2018:5804942. Epub 2018 Oct 1.

Department of High Altitude Disease, Xizang Military General Hospital, Lhasa, China.

Objective: The aim of this study was to assess the diagnostic accuracy of lung ultrasonography (LUS) for high-altitude pulmonary edema (HAPE).

Background: LUS has proven to be a reliable tool for the diagnosis of pulmonary diseases, including pneumonia, acute respiratory distress syndrome (ARDS), and pneumothorax. LUS also has potential for the diagnosis of HAPE. Read More

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https://www.hindawi.com/journals/crj/2018/5804942/
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http://dx.doi.org/10.1155/2018/5804942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188731PMC
October 2018
14 Reads

The Serum Level of IL-1B Correlates with the Activity of Chronic Pulmonary Aspergillosis.

Can Respir J 2018 27;2018:8740491. Epub 2018 Sep 27.

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Background: Until now, there have been no objective criteria to determine the activity of chronic pulmonary aspergillosis (CPA). This study aims to analyze the correlation between serum level of IL-1B and the activity of CPA and to determine whether serum IL-1B could be used to assess the activity of CPA.

Methods: A total of 469 newly diagnosed CPA patients were enrolled. Read More

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https://www.hindawi.com/journals/crj/2018/8740491/
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http://dx.doi.org/10.1155/2018/8740491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180967PMC
September 2018
11 Reads

Prevalence and Prognosis of Portopulmonary Hypertension in 223 Liver Transplant Recipients.

Can Respir J 2018 18;2018:9629570. Epub 2018 Sep 18.

Department of Cardiology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, China.

Objective: To investigate the prevalence and prognosis of portopulmonary hypertension (PoPH) in liver transplant recipients.

Methods: Patients with advanced liver disease who underwent orthotopic liver transplantation (OLT) were included in this retrospective study from January 2012 to June 2015. According to the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines for the diagnosis of pulmonary hypertension (PH), patients with tricuspid regurgitation velocity (TRV) >3. Read More

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http://dx.doi.org/10.1155/2018/9629570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167565PMC
September 2018
4 Reads

A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice.

Can Respir J 2018 18;2018:8491487. Epub 2018 Sep 18.

Department of Emergency Medicine, Hangzhou Red Cross Hospital, Hangzhou 310003, China.

Pulmonary fibrosis is a chronic and fatal disease of lung tissue with high incidence and mortality in the world. The exploration of effective treatment for pulmonary fibrosis remains an urgent challenge. In our study, Qingfei Xieding was investigated as a novel Chinese traditional patent medicine against pulmonary fibrosis. Read More

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https://www.hindawi.com/journals/crj/2018/8491487/
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http://dx.doi.org/10.1155/2018/8491487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167599PMC
September 2018
13 Reads

Inhalation Devices.

Can Respir J 2018 18;2018:5642074. Epub 2018 Sep 18.

Consultant Physician & Honorary Associate Professor, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK.

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http://dx.doi.org/10.1155/2018/5642074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167575PMC
September 2018
1 Read

Serum Tumor Necrosis Factor- and Interferon- Levels in Pediatric Pneumonia: A Systematic Review and Meta-Analysis.

Can Respir J 2018 10;2018:8354892. Epub 2018 Sep 10.

Institute of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Background: pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children. The objective of this study was to explore potential changes in levels of serum tumor necrosis factor- (TNF-) and interferon- (IFN-) associated with pediatric MPP.

Methods: This protocol has been registered (PROSPERO 2017: CRD42017077979). Read More

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https://www.hindawi.com/journals/crj/2018/8354892/
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http://dx.doi.org/10.1155/2018/8354892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151362PMC
September 2018
11 Reads

Association between Pulmonary Function and Stair-Climbing Test Results after Lung Resection: A Pilot Study.

Can Respir J 2018 9;2018:1925028. Epub 2018 Sep 9.

Department of Physical Therapy, School of Rehabilitation, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuou-ku, Kobe-shi, Hyogo 650-8530, Japan.

Background: The stair-climbing test was used to assess the exercise capacity before lung resection in subjects with lung cancer. However, few studies have systematically evaluated the role of this exercise methodology as a postoperative test. The aim of the present study was to assess whether the stair-climbing test findings reflect the postoperative decrease in pulmonary function. Read More

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http://dx.doi.org/10.1155/2018/1925028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151193PMC
September 2018
3 Reads

Usefulness of Nonvalved Spacers for Administration of Inhaled Steroids in Young Children with Recurrent Wheezing and Risk Factors for Asthma.

Can Respir J 2018 3;2018:3095647. Epub 2018 Sep 3.

Respiratory Center, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

Background: In vitro and scintigraphic studies have suggested that effectiveness of metered-dose inhalers (MDI) with nonvalved spacers (NVS) is similar to that of MDI with valved holding chambers (VHC). Nevertheless, there are no clinical studies that compare these techniques in long-term treatment with inhaled steroids in young children with recurrent wheezing and risk factors for asthma.

Objective: To compare the efficacy of a long-term treatment with Fluticasone Propionate administered by an MDI through both type of spacers, with and without valves, in young children with recurrent wheezing and risk factors for asthma. Read More

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http://dx.doi.org/10.1155/2018/3095647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140101PMC
September 2018
4 Reads

Predictors of Sleep Apnea in the Canadian Population.

Can Respir J 2018 28;2018:6349790. Epub 2018 Aug 28.

Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, 104 Clinic Place, Saskatoon, Saskatchewan, Canada S7N 2Z4.

Older age, obesity, hypertension, snoring, and excessive daytime sleepiness have been associated with sleep apnea. The objective of this study was to determine the prevalence (crude and adjusted), as well as the risk factors, of sleep apnea in the adult Canadian population. Data from the 2009 Sleep Apnea Rapid Response (SARR) questionnaire were used to identify the risk factors, and all sleep-related questions in the SARR questionnaire were used. Read More

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http://dx.doi.org/10.1155/2018/6349790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136476PMC
August 2018
2 Reads

Study of Clinical Characteristics and Cytokine Profiles of Asthmatic Children with Rhinovirus Infection during Acute Asthma Exacerbation at National Hospital of Pediatrics.

Can Respir J 2018 23;2018:9375967. Epub 2018 Aug 23.

Department of Respiratory Diseases, Medical-Biological Research Center, Lam Dong Medical College, Dalat, Vietnam.

Background: In children with asthma, the viral infection of airways is usually a main cause of acute asthma exacerbation and hospitalization. However, few studies on clinical and biomolecular characteristics of asthmatic children in this field have been done, especially in emergent countries.

Objective: This study described the clinical and biological characteristics of asthmatic children who had acute asthma exacerbation and rhinovirus (RV) infection. Read More

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http://dx.doi.org/10.1155/2018/9375967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126093PMC
August 2018
4 Reads

Role of a Community Pharmacy Service in Care of Bronchial Asthma Patients in Lithuania.

Can Respir J 2018 19;2018:6060581. Epub 2018 Aug 19.

Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuania University of Health Sciences, LT-44307 Kaunas, Lithuania.

Bronchial asthma is one of the most common chronic respiratory diseases, and its care is often complex. In this research, we tested the proposal that participation of pharmacists in the management of bronchial asthma can improve patient outcomes. A two-stage study was constructed consisting of a training element and a service element, using the Asthma Control Test and a structured questionnaire about the patients' disease condition (based on the results of a qualitative study). Read More

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http://dx.doi.org/10.1155/2018/6060581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120289PMC
August 2018
1 Read

Respiratory Care for the Ventilated Neonate.

Can Respir J 2018 13;2018:7472964. Epub 2018 Aug 13.

Department of Neonatology, Centro Hospitalar São João, Porto, Portugal.

Invasive ventilation is often necessary for the treatment of newborn infants with respiratory insufficiency. The neonatal patient has unique physiological characteristics such as small airway caliber, few collateral airways, compliant chest wall, poor airway stability, and low functional residual capacity. Pathologies affecting the newborn's lung are also different from many others observed later in life. Read More

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http://dx.doi.org/10.1155/2018/7472964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110042PMC
August 2018
17 Reads

Poorer Prognosis of Idiopathic Pleuroparenchymal Fibroelastosis Compared with Idiopathic Pulmonary Fibrosis in Advanced Stage.

Can Respir J 2018 13;2018:6043053. Epub 2018 Aug 13.

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1, West-16, Sapporo 060-8543, Japan.

Objective: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare disease characterized by predominant upper lobe pulmonary fibrosis of unknown etiology. However, the prognosis of IPPFE has not been discussed. We investigated the clinical characteristics and prognostic factors of IPPFE and idiopathic pulmonary fibrosis (IPF). Read More

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https://www.hindawi.com/journals/crj/2018/6043053/
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http://dx.doi.org/10.1155/2018/6043053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110001PMC
August 2018
6 Reads

Comparing REM- and NREM-Related Obstructive Sleep Apnea in Jordan: A Cross-Sectional Study.

Can Respir J 2018 12;2018:9270329. Epub 2018 Aug 12.

Respiratory and Sleep Medicine, The University of Jordan, Amman, Jordan.

Obstructive sleep apnea (OSA) is a common disorder that includes an intermittent mechanical obstruction of the upper airway during sleep, which can occur either during rapid eye movement (REM) phase or non-REM (NREM) phase. In this study, we aim to evaluate the differences in demographic and polysomnographic features between REM- and NREM-related OSA in a Jordanian sample, using both the broad and the restricted definitions of REM-related OSA. All patients who were referred due to clinical suspicion of OSA and underwent sleep study were screened. Read More

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http://dx.doi.org/10.1155/2018/9270329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109479PMC
August 2018
2 Reads

The Nurse Practitioners' Perspective on Inhaler Education in Asthma and Chronic Obstructive Pulmonary Disease.

Authors:
Jane Scullion

Can Respir J 2018 5;2018:2525319. Epub 2018 Aug 5.

University Hospitals of Leicester NHS Trust, Leicester, UK.

Asthma and chronic obstructive pulmonary disease (COPD) can be debilitating conditions adversely affecting a person's quality of life. Effective treatments are available, but common errors in the use of inhalers compound the issue of disease control. The beliefs and concerns of a patient can also have an impact on treatment adherence, the consequences of which are diminished disease control and the occurrence of exacerbations. Read More

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http://dx.doi.org/10.1155/2018/2525319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098863PMC
August 2018
2 Reads

Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection.

Can Respir J 2018 31;2018:1038593. Epub 2018 Jul 31.

Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada Tlalpan No. 4502, Sección XVI, 14080 Mexico City, Mexico.

Background: Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. Human neutrophil peptides (HNPs) have been found to exhibit antiadenoviral activity. Thus, we have investigated HNPs in nasal aspirates (NAs) of children suffering from adenoviral common cold. Read More

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http://dx.doi.org/10.1155/2018/1038593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091448PMC
July 2018
11 Reads

The Usefulness of the Forced Oscillation Technique in the Diagnosis of Bronchial Asthma in Children.

Can Respir J 2018 24;2018:7519592. Epub 2018 Jul 24.

Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.

The forced oscillation technique (FOT) requires minimal patient cooperation and is useful for children. However, comprehensive values of respiratory impedance at baseline and after the reversibility test have not been definitively confirmed. The aim of this study was to evaluate the basic parameters of FOT reactance (Xrs) and resistance (Rrs) in groups of healthy children and children with controlled and uncontrolled asthma. Read More

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http://dx.doi.org/10.1155/2018/7519592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081498PMC
July 2018
1 Read

Risk of Cardiovascular Events Associated with Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

Can Respir J 2018 15;2018:7097540. Epub 2018 Jul 15.

Department of Respiratory Diseases, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.

Background: The cardiovascular (CV) safety of inhaled corticosteroids (ICSs) in chronic obstructive pulmonary disease (COPD) is controversial because different studies have suggested that ICSs either increase or reduce the risk of CV events in COPD patients. In this meta-analysis, we assess the CV safety of ICS therapy in COPD.

Methods: A meta-analysis of randomized, double-blind, parallel-group, placebo-controlled trials of ICS treatment for COPD that include at least 4 weeks of follow-up was performed. Read More

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http://dx.doi.org/10.1155/2018/7097540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079461PMC
July 2018
3 Reads

Daytime Sleepiness in Patients Diagnosed with Sarcoidosis Compared with the General Population.

Can Respir J 2018 10;2018:6853948. Epub 2018 Jul 10.

Department of Respiratory Medicine, University of Leipzig, Leipzig, Germany.

Background: The aim of this study was to analyze daytime sleepiness in a sample of patients diagnosed with sarcoidosis.

Methods: A sample of 1197 German sarcoidosis patients was examined with the Epworth Sleepiness Scale (ESS), the Fatigue Assessment Scale, the Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Quality Index, and the Short-Form Health Survey (SF-8). The patients' ESS mean scores were compared with those obtained from a large general population sample. Read More

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http://dx.doi.org/10.1155/2018/6853948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079447PMC
July 2018
2 Reads

Teaching Pharmacy Undergraduate Students Inhaler Device Technique and Exploring Factors Affecting Maintenance of Technique.

Can Respir J 2018 3;2018:1597217. Epub 2018 Jul 3.

Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, NSW 2037, Australia.

Aim: To determine the effect of inhaler device technique education on the maintenance of the inhaler device technique of undergraduate pharmacy students over time and to determine the factors, if any, related to inhaler device technique maintenance in the academic setting.

Methods: This study took the form of a prospective, unpaired samples repeated measures design. Participants had their inhaler technique assessed at baseline. Read More

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http://dx.doi.org/10.1155/2018/1597217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051252PMC
July 2018
1 Read

Asthma and Asthma Medication Are Common among Recreational Athletes Participating in Endurance Sport Competitions.

Can Respir J 2018 21;2018:3238546. Epub 2018 Jun 21.

Department of Public Health and Clinical Medicine, Unit of Medicine-Östersund, Umeå University, 90187 Umeå, Sweden.

Background: Asthma prevalence is high among elite endurance athletes, but little is known about its prevalence among competitive recreational athletes. The aim of this study was to determine the prevalence of self-reported asthma and asthma medication use among competitive recreational endurance athletes and their association with training.

Methods: A web survey on asthma and medication was conducted among 38,603 adult participants of three Swedish endurance competitions (cross-country running, cross-country skiing, and swimming). Read More

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http://dx.doi.org/10.1155/2018/3238546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032657PMC
June 2018
2 Reads

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes.

Can Respir J 2018 19;2018:2732017. Epub 2018 Jun 19.

Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA.

The inhalation route is frequently used to administer drugs for the management of respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared with other routes of administration, inhalation offers a number of advantages in the treatment of these diseases. For example, via inhalation, a drug is directly delivered to the target organ, conferring high pulmonary drug concentrations and low systemic drug concentrations. Read More

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http://dx.doi.org/10.1155/2018/2732017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029458PMC
June 2018
12 Reads

Impact of Nasopharyngeal FilmArray Respiratory Panel Results on Antimicrobial Decisions in Hospitalized Patients.

Can Respir J 2018 13;2018:9821426. Epub 2018 Jun 13.

Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA.

Objective: To determine whether results of the nasopharyngeal FilmArray respiratory panel (NP-FARP) influenced antibiotic decisions.

Methods: We reviewed the medical records of nonintensive care unit (ICU) inpatients that had an NP-FARP performed at our institution between June 2013 and June 2014. The inpatient records were reviewed 48 hours after the NP-FARP for the following data: demographic information; NP-FARP, serum procalcitonin, and methicillin-resistant nasal swab (MRSA NS) results; antibiotics prior and post-48 hours of the NP-FARP result; and the current immunosuppression status. Read More

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http://dx.doi.org/10.1155/2018/9821426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020531PMC
June 2018
12 Reads

Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation.

Can Respir J 2018 3;2018:8959370. Epub 2018 Jun 3.

Department of Pneumonology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

The administration of aerosolized medication is a basic therapy for patients with numerous respiratory tract diseases, including obstructive airway diseases (OADs), cystic fibrosis (CF), and infectious airway diseases. The management and care for patients requiring mechanical ventilation remains one of the greatest challenges for medical practitioners, both in intensive care units (ICUs) and pulmonology wards. Aerosol therapy is often necessary for patients receiving noninvasive ventilation (NIV), which may be stopped for the time of drug delivery and administered through a metered-dose inhaler or nebulizer in the traditional way. Read More

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http://dx.doi.org/10.1155/2018/8959370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008820PMC
June 2018
17 Reads

The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome.

Can Respir J 2018 3;2018:3297810. Epub 2018 Jun 3.

Pulmonology Department, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS).

Materials And Method: 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded. Read More

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http://dx.doi.org/10.1155/2018/3297810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008913PMC
June 2018
6 Reads

Erratum to "ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis".

Can Respir J 2018 5;2018:2648196. Epub 2018 Jun 5.

Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

[This corrects the article DOI: 10.1155/2018/5712805.]. Read More

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http://dx.doi.org/10.1155/2018/2648196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008819PMC
June 2018
14 Reads
1.660 Impact Factor

Matching Inhaler Devices with Patients: The Role of the Primary Care Physician.

Can Respir J 2018 23;2018:9473051. Epub 2018 May 23.

University of Aberdeen, Aberdeen, UK.

Poor inhaler technique and nonadherence impair the efficacy of medications for asthma and chronic obstructive pulmonary disease (COPD). A range of factors, including age, dexterity, inspiratory capacity, cognitive ability, health literacy, and ethnicity, can impact a patient's ability and intention to use their device. Treatment success can also be influenced by patient preferences and perceptions. Read More

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http://dx.doi.org/10.1155/2018/9473051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989279PMC
May 2018
7 Reads

Corrigendum to "Fully Covered Metallic Stents for the Treatment of Benign Airway Stenosis".

Can Respir J 2018 22;2018:6202750. Epub 2018 May 22.

Division of Pulmonology, CHU UCL Namur (Godinne Site), Université catholique de Louvain (UcL), Yvoir, Namur, Belgium.

[This corrects the article DOI: 10.1155/2016/8085216.]. Read More

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http://dx.doi.org/10.1155/2018/6202750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987266PMC
May 2018
3 Reads

Pretreatment Hemoglobin Level Is an Independent Prognostic Factor in Patients with Lung Adenocarcinoma.

Can Respir J 2018 15;2018:6328127. Epub 2018 May 15.

Department of Oncology, Huaihe Hospital of Henan University, Kaifeng 475001, China.

Background/aim: Few studies have reported the prognostic value of pretreatment hemoglobin levels in patients with lung adenocarcinoma (LA). In the present study, we retrospectively reviewed 306 LA patients for their prognosis associated with the pretreatment hemoglobin levels.

Methods: Person-years and case fatality rate (CFR) were calculated from May 2010 to June 2017. Read More

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http://dx.doi.org/10.1155/2018/6328127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977049PMC
May 2018
2 Reads

EZH2 Inhibition Ameliorates Transverse Aortic Constriction-Induced Pulmonary Arterial Hypertension in Mice.

Can Respir J 2018 28;2018:9174926. Epub 2018 Feb 28.

Department of Intensive Care Unit, Hangzhou Red Cross Hospital/Zhejiang Chinese Medicine, Western Medicine Integrated Hospital, Hangzhou 310003, China.

Background: EPZ005687 is a selective inhibiter of methyltransferase EZH2. In this article, we investigated the protective role and mechanism of EPZ005687 in transverse aortic constriction-induced pulmonary arterial hypertension in mice.

Methods: We assigned 15 (6-8 weeks old) male balb/c mice to 3 groups randomly: Sham control + DMSO group, TAC + DMSO group, and TAC + EPZ005687 group (10 mg kg, once a week for 4 weeks). Read More

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http://dx.doi.org/10.1155/2018/9174926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960552PMC
February 2018
17 Reads

Model for Developing a Health-Related Quality of Life Questionnaire for Chronic Obstructive Pulmonary Disease.

Can Respir J 2018 2;2018:6450962. Epub 2018 May 2.

Faculty of Philosophy, University of Montenegro, 81000 Podgorica, Montenegro.

Introduction: The St. George's Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) Dyspnea Scale, Hospital Anxiety and Depression Scale (HADS), and general health questionnaire (SF-36) are widely used for chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD).

Aim: We examined the reliability and validity of a modified questionnaire (MQ) to create a model for assessing the health-related quality of life (HRQOL) in COPD. Read More

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http://dx.doi.org/10.1155/2018/6450962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954916PMC
May 2018
4 Reads

Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice.

Can Respir J 2018 2;2018:5259240. Epub 2018 May 2.

Department of Pediatrics, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.

Background And Objective: While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction with budesonide.

Methods: A mouse model of asthma was established by allergic sensitization and challenge with ovalbumin. Read More

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http://dx.doi.org/10.1155/2018/5259240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954913PMC
May 2018
3 Reads

Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control.

Can Respir J 2018 8;2018:4835823. Epub 2018 May 8.

Medical Informatics Research Laboratory of the Higher School of Information Technologies and Information Systems, Kazan Federal University, 18 Kremlyovskaya St., Kazan, Republic of Tatarstan 420008, Russia.

Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8. Read More

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http://dx.doi.org/10.1155/2018/4835823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964596PMC
May 2018
2 Reads

Transition from Ambrisentan to Bosentan in Pulmonary Arterial Hypertension: A Single-Center Prospective Study.

Can Respir J 2018 11;2018:9836820. Epub 2018 Apr 11.

Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

: Two endothelin receptor antagonists (ETRAs), bosentan and ambrisentan, are approved for patients with pulmonary arterial hypertension (PAH). However, there is little information about the transition strategy between these two ETRAs. We aimed to evaluate the safety and efficacy from ambrisentan to bosentan. Read More

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http://dx.doi.org/10.1155/2018/9836820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924990PMC
April 2018
8 Reads

ELISA Development for Serum Hemeoxygenase-1 and Its Application to Patients with Acute Respiratory Distress Syndrome.

Can Respir J 2018 18;2018:9627420. Epub 2018 Apr 18.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: Hemeoxygenase-1 (HO-1) is an essential enzyme in heme catabolism and has been proposed as a biomarker of lung disease prognosis. We modified a commercial HO-1 enzyme-linked immunosorbent assay (ELISA) kit to achieve higher sensitivity and evaluated if serum HO-1 could be a biomarker to predict the prognosis of acute respiratory distress syndrome (ARDS) patients.

Methods: Serum samples were collected from 15 healthy volunteers to validate the modified ELISA. Read More

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http://dx.doi.org/10.1155/2018/9627420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932439PMC
April 2018
4 Reads

Verification of a Motion Sensor for Evaluating Physical Activity in COPD Patients.

Can Respir J 2018 23;2018:8343705. Epub 2018 Apr 23.

Department of Clinical Laboratory, National Hospital Organization Wakayama Hospital, 1138 Wada Mihama-cho, Hidaka-gun, Wakayama 644-0044, Japan.

Background: Objective evaluation of the physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) is important. We validated a triaxial accelerometer, Active Style Pro HJA-750C® (HJA), and evaluated the necessary conditions for obtaining reproducible data.

Methods: The PA measured by HJA was compared with that measured by two already validated accelerometers in 11 patients with COPD (age: 76. Read More

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http://dx.doi.org/10.1155/2018/8343705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937578PMC
April 2018
6 Reads