1,428 results match your criteria Canadian Respiratory Journal[Journal]


Clinical Characteristics of Six Cases of Tracheobronchopathia Osteochondroplastica.

Can Respir J 2020 16;2020:8685126. Epub 2020 Jun 16.

People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

Objective: To investigate the clinical characteristics of tracheobronchopathia osteochondroplastica (TO).

Methods: The clinical data of six patients with TO from November 2016 to November 2018 were retrospectively analyzed. The etiology, clinical manifestations, diagnosis, and treatment of TO were summarized. Read More

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http://dx.doi.org/10.1155/2020/8685126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315312PMC

Usefulness of Positron Emission Tomography in the Examination of Hilar and Mediastinal Lymphadenopathies in Patients with Suspicion of Lung Cancer.

Can Respir J 2020 5;2020:7909543. Epub 2020 Jun 5.

Escuela de Medicina, Universidad de Santiago de Compostela, Área de Medicina Preventiva y Salud Pública, Santiago de Compostela, Spain.

Introduction: Lung cancer is a major health problem. Mediastinal staging performed with the aid of imaging techniques is essential for appropriate disease treatment and prognosis. Accordingly, this study aimed to ascertain the usefulness of positron emission tomography (PET) in mediastinal staging, establish the best maximum standardized uptake value (SUV) cutoff point, compare its usefulness to that of computed tomography (CT), and determine the influence of histological tumour subtype. Read More

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http://dx.doi.org/10.1155/2020/7909543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294363PMC

Massive Hemoptysis in Children.

Can Respir J 2020 6;2020:6414719. Epub 2020 Jun 6.

Department of Pediatric, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.

. Hemoptysis is a rare but often life-threatening condition in pediatric patients. Massive hemoptysis can easily lead to asphyxia, respiratory failure, shock, and even death. Read More

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http://dx.doi.org/10.1155/2020/6414719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305531PMC

Thoracic Complications in Behçet's Disease: Imaging Findings.

Can Respir J 2020 28;2020:4649081. Epub 2020 May 28.

Department of Chest Clinic, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey.

Behçet's disease (BD) causes vascular inflammation and necrosis in a wide range of organs and tissues. In the thorax, it may cause vascular complications, affecting the aorta, brachiocephalic arteries, bronchial arteries, pulmonary arteries, pulmonary veins, capillaries, and mediastinal and thoracic inlet veins. In BD, chest radiograph is commonly used for the initial assessment of pulmonary symptoms and complications and for follow-up and establishment of the response to treatment. Read More

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http://dx.doi.org/10.1155/2020/4649081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275231PMC

Alpha-1 Antitrypsin Deficiency and Pulmonary Morbidity in Patients with Primary Immunodeficiency Disease: A Single-Center Experience.

Can Respir J 2020 27;2020:4019608. Epub 2020 May 27.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.

Background: Alpha-1 antitrypsin deficiency (AATD) is of importance in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary diseases (COPD), and bronchiectasis. Various pulmonary disorders are a typical feature of primary immunodeficiency disease (PID). This includes recurrent pulmonary infections, immunodysregulation, and autoinflammatory diseases. Read More

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http://dx.doi.org/10.1155/2020/4019608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273390PMC

Identification of a Mutation in the Novel Compound Heterozygous CFTR in a Chinese Family with Cystic Fibrosis.

Can Respir J 2020 7;2020:6507583. Epub 2020 May 7.

Tianjin Institute of Respiratory Diseases, Tianjin 300350, China.

Cystic fibrosis (CF) is one of the most common autosomal recessive disorders among Caucasians of Northern European descent but is uncommon in the Chinese population. . To elucidate the mutation in the novel compound heterozygous CFTR causing CF in Chinese family. Read More

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http://dx.doi.org/10.1155/2020/6507583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229557PMC
May 2020
1.663 Impact Factor

Impacts of Coil Treatment on Anxiety and Depression in Emphysema.

Can Respir J 2020 11;2020:4270826. Epub 2020 May 11.

Department of Pulmonology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Chronic obstructive pulmonary disease (COPD) is a widespread, preventable, and treatable disease. Emphysema is one of the primary components of COPD and manifests itself via decrease in elastic recoil, hyperinflation, and increase in air trapping. Various lung-volume-reduction treatments have come up in recent years for late-stage emphysema patients. Read More

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http://dx.doi.org/10.1155/2020/4270826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240628PMC

The Impact of Hyperoxia on Outcome of Patients Treated with Noninvasive Respiratory Support.

Can Respir J 2020 6;2020:3953280. Epub 2020 May 6.

Department of Internal Medicine and Medical Intensive Care, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Objective: Oxygen therapy is one of the most common treatment modalities for hypoxemic patients, but target goals for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxia is a very common situation. The results from the recent clinical researches about hyperoxia indicate that hyperoxia can be related to worse outcomes than expected in some critically ill patients. Read More

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http://dx.doi.org/10.1155/2020/3953280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225844PMC
May 2020
1.663 Impact Factor

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS.

Can Respir J 2020 4;2020:2571283. Epub 2020 May 4.

Okmeydanı Training and Research Hospital, Chest Diseases Clinic, Kaptan Pasa Mahallesi, Darulaceze Cad. No. 25, 34384 Istanbul, Turkey.

Objective: The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display significant metabolic and cardiovascular functions and the levels of proinflammatory cytokine levels.

Method: A total of 166 overweight and obese male patients with a body mass index (BMI) >27 kg/m were included in the study. Among study participants, 84 were recently diagnosed with OSAS by polysomnography with an apnea-hypopnea index (AHI) ≥5, and 82 were nonapneic with normal polysomnography (AHI<5) findings. Read More

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http://dx.doi.org/10.1155/2020/2571283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225856PMC

Combination of Fractional Exhaled Nitric Oxide (FeNO) Level and Asthma Control Test (ATC) in Detecting GINA-Defined Asthma Control in Treated Asthmatic Patients in Vietnam.

Can Respir J 2020 25;2020:5735128. Epub 2020 Apr 25.

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands.

Background: FeNO has been used as a marker for Th2-mediated airway inflammation in asthma. There is evidence which recommends the use of this biomarker in asthma management. Little is known about whether the FeNO test alone or in combination with the ACT score can reflect asthma control in Vietnamese patients. Read More

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http://dx.doi.org/10.1155/2020/5735128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196968PMC
April 2020
1.663 Impact Factor

The Value of Combined Radial Endobronchial Ultrasound-Guided Transbronchial Lung Biopsy and Metagenomic Next-Generation Sequencing for Peripheral Pulmonary Infectious Lesions.

Can Respir J 2020 6;2020:2367505. Epub 2020 Apr 6.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.

Background: Metagenomic next-generation sequencing (mNGS) is a new technology that allows for unbiased detection of pathogens. However, there are few reports on mNGS of lung biopsy tissues for pulmonary infection diagnosis. In addition, radial endobronchial ultrasound (R-EBUS) is widely used to detect peripheral pulmonary lesions (PPLs), but it is rarely used in the diagnosis of peripheral lung infection. Read More

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http://dx.doi.org/10.1155/2020/2367505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165338PMC

Special Staining of the Liquid-Based Cytopathology Test in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients.

Can Respir J 2020 31;2020:8243473. Epub 2020 Mar 31.

Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China.

In recent years, various biomarkers have been gradually applied on bronchoalveolar lavage (BAL) fluid for the diagnosis of invasive pulmonary aspergillosis (IPA). The objective of this study is to assess the value of the liquid-based cytopathology test (LCT) for improving the identification of IPA in BAL fluid from possible IPA patients, following special staining with periodic acid-Schiff staining (PAS) or Grocott's methenamine silver (GMS). A total of 47 consecutive possible IPA patients who underwent bronchoscopy with BAL fluid from January 2017 to December 2018 were included. Read More

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http://dx.doi.org/10.1155/2020/8243473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150679PMC

Erratum to "Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress".

Can Respir J 2020 21;2020:6958283. Epub 2020 Feb 21.

Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.

[This corrects the article DOI: 10.1155/2019/7930396.]. Read More

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http://dx.doi.org/10.1155/2020/6958283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150693PMC
February 2020

Genetic Evolution of Conferring Clarithromycin Resistance during Long-Term Antibiotic Therapy.

Can Respir J 2020 28;2020:7623828. Epub 2020 Mar 28.

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Objectives: Clarithromycin is recommended as the core agent for treating infections, which usually calls for at least one year of treatment course, facilitating the development of resistance. This study aimed to identify the underlying mechanism of development of clarithromycin resistance in clinical isolates.

Methods: isolates from patients with lung infections during long-term antibiotic therapy were longitudinally collected and sequenced. Read More

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http://dx.doi.org/10.1155/2020/7623828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142343PMC

Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria.

Can Respir J 2020 26;2020:7142568. Epub 2020 Mar 26.

Division of Interventional Pulmonology and Thoracic Surgery, Swedish Cancer Institute, Seattle, WA, USA.

The National Comprehensive Cancer Network expanded their lung cancer screening (LCS) criteria to comprise one additional clinical risk factor, including chronic obstructive pulmonary disease (COPD). The electronic medical record (EMR) is a source of clinical information that could identify high-risk populations for LCS, including a diagnosis of COPD; however, an unsubstantiated COPD diagnosis in the EMR may lead to inappropriate LCS referrals. We aimed to detect the prevalence of unsubstantiated COPD diagnosis in the EMR for LCS referrals, to determine the efficacy of utilizing the EMR as an accurate population-based eligibility screening "trigger" using modified clinical criteria. Read More

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http://dx.doi.org/10.1155/2020/7142568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136785PMC

Relationship between Particulate Matter (PM) and Airway Inflammation Measured with Exhaled Nitric Oxide Test in Seoul, Korea.

Can Respir J 2020 17;2020:1823405. Epub 2020 Mar 17.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Republic of Korea.

Purpose: Particulate matter (PM) is increasing every year in Asia. It is not fully understood how the airway is affected when inhaling PM. We investigated the correlation between particulate matter with a diameter of less than 10 m (PM) and fractional exhaled nitric oxide (FeNO) to determine whether PM causes airway inflammation. Read More

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http://dx.doi.org/10.1155/2020/1823405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103060PMC

Analysis of Optimal Health-Related Quality of Life Measures in Patients Waitlisted for Lung Transplantation.

Can Respir J 2020 5;2020:4912920. Epub 2020 Mar 5.

Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Improving health-related quality of life (HRQL) is an important goal of lung transplantation, and St. George's Respiratory Questionnaire (SGRQ) is frequently used for assessing HRQL in patients waitlisted for lung transplantation. We hypothesized that chronic respiratory failure (CRF)-specific HRQL measures would be more suitable than the SGRQ, considering the underlying disease and its severity in these patients. Read More

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http://dx.doi.org/10.1155/2020/4912920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077042PMC

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure.

Can Respir J 2020 20;2020:2301712. Epub 2020 Feb 20.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100000, China.

Severe bronchial asthma complicated with respiratory failure, a common critical illness in respiratory medicine, may be life-threatening. High-flow nasal cannula (HFNC) is a novel oxygen therapy technique developed in recent years. HFNC was applied in this study for treating adult patients with severe bronchial asthma complicated with respiratory failure. Read More

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http://dx.doi.org/10.1155/2020/2301712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054795PMC
February 2020

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety.

Can Respir J 2020 22;2020:9046842. Epub 2020 Feb 22.

Department of Respiration and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.

Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely related to the adverse perinatal outcomes of mother and fetus. This article provides an update on the available literature regarding the alleviating or aggravating mechanism of asthma in pregnancy, diagnosis, disease assessment, and systematic management, to provide a new guidance for physician, obstetric joint doctor, and health care practitioner. Read More

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http://dx.doi.org/10.1155/2020/9046842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060439PMC
February 2020

Upregulation of Potassium Voltage-Gated Channel Subfamily J Member 2 Levels in the Lungs of Patients with Idiopathic Pulmonary Fibrosis.

Can Respir J 2020 25;2020:3406530. Epub 2020 Feb 25.

Genome Research Center and Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Background: Fibroblast dysfunction is the main pathogenic mechanism underpinning idiopathic pulmonary fibrosis (IPF). Potassium voltage-gated channel subfamily J member 2 (KCNJ2) plays critical roles in the proliferation of myofibroblasts and in the development of cardiac fibrosis.

Objectives: This study aimed to evaluate the role of KCNJ2 in IPF. Read More

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http://dx.doi.org/10.1155/2020/3406530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061125PMC
February 2020

Normative Values for Londrina ADL Protocol in Healthy Individuals in Age Group of 40-60 Years among Indian Population: A Cross-Sectional Study.

Can Respir J 2020 18;2020:8612928. Epub 2020 Feb 18.

Department of Pulmonary Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore-575004, India.

Background: Due to increase in the life expectancy and changes related to aging, it is important to assess ADL (activities of daily living) in older adults. However, there is no standardized protocol available to assess ADLs. Considering the limitations of the available tools, a new protocol named Londrina ADL protocol was developed for which normative values are unavailable in different ethnic groups. Read More

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http://dx.doi.org/10.1155/2020/8612928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049403PMC
February 2020

MIP-T3 Expression Associated with Defects of Ciliogenesis in Airway of COPD Patients.

Can Respir J 2020 10;2020:1350872. Epub 2020 Feb 10.

Department of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.

. Some studies have found that cilia were shorter in COPD smokers than in nonsmokers or healthy smokers. However, the structural abnormalities of cilia and the cause of such abnormalities in COPD patients still remain unknown. Read More

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http://dx.doi.org/10.1155/2020/1350872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035511PMC
February 2020

Postinfectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report.

Can Respir J 2020 30;2020:5852827. Epub 2020 Jan 30.

Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.

Bronchiolitis obliterans (BO) is a rare, chronic form of obstructive lung disease, often initiated with injury of the bronchiolar epithelium followed by an inflammatory response and progressive fibrosis of small airways resulting in nonuniform luminal obliteration or narrowing. The term BO comprises a group of diseases with different underlying etiologies, courses, and characteristics. Among the better recognized inciting stimuli leading to BO are airway pathogens such as adenovirus and mycoplasma, which, in a small percentage of infected children, will result in progressive fixed airflow obstruction, an entity referred to as postinfectious bronchiolitis obliterans (PIBO). Read More

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http://dx.doi.org/10.1155/2020/5852827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013295PMC
January 2020

Comparisons of Metabolic Load between Adaptive Support Ventilation and Pressure Support Ventilation in Mechanically Ventilated ICU Patients.

Can Respir J 2020 28;2020:2092879. Epub 2020 Jan 28.

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Purpose: The aim of this study was to compare the metabolic load between adaptive support ventilation (ASV) and pressure support ventilation (PSV) modes in critically ill patients.

Methods: Sequential 20 min ventilation by PSV followed by 20 min ASV in critically ill patients was assessed. ASV was set for full support, i. Read More

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http://dx.doi.org/10.1155/2020/2092879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008273PMC
January 2020

Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis.

Can Respir J 2020 17;2020:4213807. Epub 2020 Jan 17.

Department of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.

Objective: This study aims to explore the role of erythromycin-regulated histone deacetylase-2 in benign tracheal stenosis.

Methods: The rabbit model of tracheal stenosis was established. The rabbits were randomly divided into 8 groups. Read More

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http://dx.doi.org/10.1155/2020/4213807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995498PMC
January 2020

Lifestyle and Sociodemographic and Economic Characteristics of Patients with Lung Cancer in Morocco.

Can Respir J 2020 6;2020:8031541. Epub 2020 Jan 6.

Laboratory of Human Ecology, Semlalia Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco.

Background: Lifestyle maintenance is a crucial condition before and after lung cancer disease. According to the previous research in the scientific databases, the effect of the interaction between socioeconomic and demographic factors on the lifestyle of lung cancer patients in Southern Morocco regions remains unexamined. Accordingly, this study was designed to examine the relationship between socioeconomic factors, demographic factors, and the lifestyle of lung cancer patients. Read More

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http://dx.doi.org/10.1155/2020/8031541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975217PMC
January 2020

Association of Tobacco Smoking with Physical Fitness of Military Males in Taiwan: The CHIEF Study.

Can Respir J 2020 7;2020:5968189. Epub 2020 Jan 7.

Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien County, Taiwan.

Tobacco smoking has been found associated with lower cardiorespiratory fitness in white and black males; however, few studies have not been conducted to clarify such relationship in Asian males. We performed a cross-sectional study to investigate the association between tobacco smoking status and physical fitness in 3,669 military males, averaged 29.4 years of age, from the cardiorespiratory fitness and hospitalization events in armed forces (CHIEF) study in Taiwan during 2014. Read More

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http://dx.doi.org/10.1155/2020/5968189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969999PMC
January 2020
1.663 Impact Factor

Nonadherence in Home-Based Pulmonary Rehabilitation Program for COPD Patients.

Can Respir J 2020 7;2020:5146765. Epub 2020 Jan 7.

Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.

Background: The pulmonary rehabilitation (PR) is beneficial for COPD patients. Due to the poor rate of adherence, we evaluate the factors which will predict the nonadherence of PR.

Method: We analyzed the data from a retrospective study of COPD patients who were enrolled to attend the PR program. Read More

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http://dx.doi.org/10.1155/2020/5146765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969984PMC
January 2020

Validation of the NoSAS Score for the Screening of Sleep-Disordered Breathing in a Sleep Clinic.

Can Respir J 2020 8;2020:4936423. Epub 2020 Jan 8.

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China.

Background: There is a growing number of patients with sleep-disordered breathing (SDB) referred to sleep clinics. Therefore, a simple but useful screening tool is urgent. The NoSAS score, containing only five items, has been developed and validated in population-based studies. Read More

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http://dx.doi.org/10.1155/2020/4936423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977329PMC
January 2020

Accuracy of Ultrasound in Diagnosis of Pneumothorax: A Comparison between Neonates and Adults-A Systematic Review and Meta-Analysis.

Can Respir J 2019 3;2019:5271982. Epub 2019 Dec 3.

Students Research Committee, Zabol University of Medical Sciences, Zabol, Iran.

Objective: The present systematic review and meta-analysis were conducted to investigate the accuracy of ultrasound in the diagnosis of pneumothorax in neonates and adults.

Method: The searches were conducted by two independent researchers (MS and HD) to find the relevant studies published from 01/01/2009 until the end of 01/01/2019. We searched for published literature in the English language in MEDLINE via PubMed, Embase™ via ovid, the Cochrane Library, and Trip database. Read More

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http://dx.doi.org/10.1155/2019/5271982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942780PMC
December 2019

Comparison of Diagnostic Yield and Safety between Semirigid Pleuroscopic Cryobiopsy and Forceps Biopsy for Undiagnosed Pleural Effusion.

Can Respir J 2019 17;2019:5490896. Epub 2019 Dec 17.

Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan.

For undiagnosed pleural effusion, diagnostic yields and safety were similar between pleuroscopic cryobiopsy and forceps biopsy, but cryobiopsy obtained a larger pleural tissue sample than forceps biopsy. Read More

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http://dx.doi.org/10.1155/2019/5490896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939421PMC
December 2019

Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer.

Can Respir J 2019 27;2019:9107806. Epub 2019 Nov 27.

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province 130033, China.

Background: The small molecule inhibitor XAV939 could inhibit the proliferation and promote the apoptosis of non-small cell lung cancer () cells. This study was conducted to identify the key circular RNAs (circRNAs) and microRNAs (miRNAs) in XAV939-treated NSCLC cells.

Methods: After grouping, the NCL-H1299 cells in the treatment group were treated by 10 M XAV939 for 12 h. Read More

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http://dx.doi.org/10.1155/2019/9107806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900950PMC
November 2019

Serum Levels of Epithelial-Derived Cytokines as Interleukin-25 and Thymic Stromal Lymphopoietin after a Single Dose of Mepolizumab in Patients with Severe Non-Allergic Eosinophilic Asthma: A Short Report.

Can Respir J 2019 1;2019:8607657. Epub 2019 Dec 1.

Department of Pulmonology, Lithuanian University of Health Sciences, Kaunas, LT-50161, Lithuania.

The bronchial epithelium has continuous contact with environmental agents initiating and maintaining airway type 2 inflammation in asthma. However, there is a lack of data on whether reduced airway eosinophilic inflammation can affect the production of epithelial-derived mediators, such as interleukin-25 (IL-25) and thymic stromal lymphopoietin (TSLP). The aim of this study was to investigate the changes in serum levels of IL-25 and TSLP after a single dose of mepolizumab, a humanized monoclonal antibody to interleukin-5 (IL-5), in patients with severe non-allergic eosinophilic asthma (SNEA). Read More

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http://dx.doi.org/10.1155/2019/8607657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914925PMC
December 2019
1.663 Impact Factor

Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis.

Can Respir J 2019 1;2019:7262065. Epub 2019 Dec 1.

Department of Rheumatology, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, Shanxi 030001, China.

Objective: The absolute and relative changes of peripheral NK and T subsets are unclear in rheumatoid arthritis (RA) associated with pulmonary interstitial fibrosis (RA-ILD). To investigate the clinical risk factors, especially the changes of lymphocyte subsets, in RA-ILD in order to make early diagnosis and achieve prevention of the pulmonary interstitial lesions.

Methods: A total of 100 RA and 100 RA-ILD patients were enrolled. Read More

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http://dx.doi.org/10.1155/2019/7262065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914899PMC
December 2019

Palivizumab Prophylaxis among Infants at Increased Risk of Hospitalization due to Respiratory Syncytial Virus Infection in UAE: A Hospital-Based Study.

Can Respir J 2019 1;2019:2986286. Epub 2019 Dec 1.

Neonatal Intensive Care Unit, Latifa Women & Children Hospital, Dubai Health Authority, Dubai, UAE.

Background: Respiratory syncytial virus (RSV) represents a significant public health burden and the leading cause of lower respiratory tract infections globally, and it is the major cause of hospitalization during the winter. We aimed to evaluate the effectiveness of palivizumab prophylaxis to reduce the hospitalization in children at high risk of RSV infection.

Methods: We performed a retrospective observational single-arm hospital-based study including five RSV seasons (September to March) from 2012 to 2017. Read More

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http://dx.doi.org/10.1155/2019/2986286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913160PMC
December 2019

Overexpression of MALAT1 Relates to Lung Injury through Sponging miR-425 and Promoting Cell Apoptosis during ARDS.

Can Respir J 2019 1;2019:1871394. Epub 2019 Dec 1.

Department of Oncology, Renmin Hospital of Wuhan Unversity, Wuhan, China.

Background: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury during which severe inflammatory responses induce cell apoptosis, necrosis, and fibrosis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a multiple function long noncoding RNA that was found overexpressed during acute lung injury. However, the roles of MALAT1 in ARDS patients are still unknown. Read More

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http://dx.doi.org/10.1155/2019/1871394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913333PMC
December 2019

Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress.

Can Respir J 2019 3;2019:7930396. Epub 2019 Nov 3.

Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Background: Imbalanced oxidative stress and antioxidant defense are involved in airway remodeling in asthma. It has been demonstrated that Tetrandrine has a potent role in antioxidant defense in rheumatoid arthritis and hypertension. However, the correlation between Tetrandrine and oxidative stress in asthma is utterly blurry. Read More

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http://dx.doi.org/10.1155/2019/7930396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875008PMC

Practical Aspects of Interface Application in CPAP Treatment.

Can Respir J 2019 3;2019:7215258. Epub 2019 Nov 3.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

While continuous positive airway pressure (CPAP) is an effective first-line therapy for sleep apnea, CPAP fails in one third of patients mainly due to poor adherence to the CPAP device and masks. The role of the medical team is to guide the patient in choosing the best mask, thus insuring good CPAP therapy adherence. Once a suitable mask is found, the brand of the mask does not affect patient satisfaction or CPAP adherence. Read More

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http://dx.doi.org/10.1155/2019/7215258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874967PMC

The Role of Immunotherapy in Extensive Stage Small-Cell Lung Cancer: A Review of the Literature.

Can Respir J 2019 3;2019:6860432. Epub 2019 Nov 3.

Pulmonary Department, Aristotle University of Thessalloniki, G. Papanikolaou Hospital, Exohi, Thessaloniki 57010, Greece.

Lung cancer is the second most common cancer in both sexes worldwide. Small-cell lung cancer (SCLC) is a form of neuroendocrine tumor, which is classified into limited and extensive-stage disease and shows excellent initial response to chemotherapy; however, almost all patients relapse later. During the past few years, several clinical trials have evaluated the effect of addition of immunotherapy to conventional chemotherapy in patients with extensive SCLC. Read More

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http://dx.doi.org/10.1155/2019/6860432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875088PMC

Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea.

Can Respir J 2019 3;2019:2047674. Epub 2019 Nov 3.

Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Obstructive sleep apnea (OSA) can lead to serious complications such as coronary heart disease and hypertension due to oxidative stress. Sestrin2 expression is upregulated under conditions of oxidative stress. This study aimed to explore whether Sestrin2 was involved in OSA. Read More

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http://dx.doi.org/10.1155/2019/2047674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874949PMC

Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma.

Can Respir J 2019 1;2019:6462171. Epub 2019 Oct 1.

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Rationale: We previously demonstrated increased expression of programmed cell death 5 (PDCD5) in asthmatic patients and ovalbumin-induced allergic asthma. International guidelines (GINA 2019) have included the use of tiotropium bromide for chronic treatment of the most severe and frequently exacerbated asthma in patients ≥6 years old, who do not have good response to inhaled corticosteroids.

Objective: To explore the role of tiotropium and its effect on PDCD5 level in a mouse model of chronic asthma. Read More

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http://dx.doi.org/10.1155/2019/6462171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791200PMC

Comment on "Noninvasive Ventilation Weaning in Acute Hypercapnic Respiratory Failure due to COPD Exacerbation: A Real-Life Observational Study".

Can Respir J 2019 1;2019:5490510. Epub 2019 Oct 1.

Intensive Care Unit, Hospital Morales Meseguer, Murcia 30500, Spain.

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http://dx.doi.org/10.1155/2019/5490510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791258PMC
November 2019
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1.663 Impact Factor

Impact of Group Asthma Education on Asthma Control and Emergency Room Visits in an Underserved New York Community.

Can Respir J 2019 1;2019:5165189. Epub 2019 Oct 1.

Division of Pulmonary and Critical Care Medicine, BronxCare Health System, 1650 Grand Concourse, Bronx, NY 10457, USA.

Objective: Asthma education programs have been shown to be effective in decreasing health care utilization and improving disease control and management. However, there are few studies evaluating the outcomes of group asthma education. The aim of this study was to assess the impact of an outpatient adult group asthma education program in an inner-city-based hospital caring for an underserved population. Read More

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http://dx.doi.org/10.1155/2019/5165189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791196PMC

P27 Promotes TGF--Mediated Pulmonary Fibrosis via Interacting with MTORC2.

Can Respir J 2019 19;2019:7157861. Epub 2019 Sep 19.

The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu 322000, China.

Pulmonary fibrosis (PF), a progressive and life-threatening pulmonary disease, is the main pathological basis of interstitial lung disease (ILD) which includes the idiopathic pulmonary fibrosis (IPF). No effective therapeutic strategy for pulmonary fibrosis has been established. TGF- signaling has emerged as the vital regulator of PF; however, the detailed molecular mechanisms of TGF- in PF were uncertain. Read More

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http://dx.doi.org/10.1155/2019/7157861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770332PMC

Psychometric Testing of the CHAMPS Questionnaire in French Canadians with COPD.

Can Respir J 2019 17;2019:2185207. Epub 2019 Sep 17.

McGill University, School of Physical & Occupational Therapy, Montréal H3G 1Y5, Québec, Canada.

Physical activity is an important health behaviour in reducing morbidity and mortality in individuals with chronic obstructive pulmonary disease (COPD). Accurate measurement of the characteristics of physical activity is essential to understanding the impact of COPD on physical activity. In a previous article, we reported on the cross-cultural adaptation of the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire to produce a Canadian French version. Read More

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http://dx.doi.org/10.1155/2019/2185207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766162PMC
April 2020
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The Prevalence of Asthma and Respiratory Symptoms among Cross-Country Skiers in Early Adolescence.

Can Respir J 2019 15;2019:1514353. Epub 2019 Sep 15.

Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Östersund, Sweden.

Objective: To determine the prevalence of asthma and respiratory symptoms among Swedish cross-country skiers in early adolescence in comparison to a population-based reference group of similar ages.

Methods: A postal questionnaire on asthma, asthma medication, allergy, respiratory symptoms, and physical activity was distributed to Swedish competitive cross-country skiers aged 12-15 years ( = 331) and a population-based reference group ( = 1000). The level of asthma control was measured by the Asthma Control Test. Read More

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http://dx.doi.org/10.1155/2019/1514353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766134PMC

The Airways' Mechanical Stress in Lung Disease: Implications for COPD Pathophysiology and Treatment Evaluation.

Can Respir J 2019 5;2019:3546056. Epub 2019 Sep 5.

Department of Biomedical and Clinical Science (DIBIC), Università Degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco-Polo Universitario, ASST Fatebenefratelli-Sacco, Milan, Italy.

The airway epithelium stretches and relaxes during the normal respiratory cycle, and hyperventilation exaggerates this effect, resulting in changes in lung physiology. In fact, stretching of the airways influences lung function and the secretion of airway mediators, which in turn may cause a potentially injurious inflammatory response. This aim of the present narrative review was to illustrate the current evidence on the importance of mechanical stress in the pathophysiology of lung diseases with a particular focus on chronic obstructive pulmonary disease (COPD) and to discuss how this may influence pharmacological treatment strategies. Read More

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http://dx.doi.org/10.1155/2019/3546056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748188PMC

Concomitant Interstitial Lung Disease with Psoriasis.

Can Respir J 2019 25;2019:5919304. Epub 2019 Aug 25.

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: We encounter interstitial lung disease (ILD) patients with psoriasis. The aim of this case series was to examine clinical and radiographic characteristics of patients with concomitant psoriasis and ILD.

Methods: This is a retrospective review of our institutional experience of ILD concomitant with psoriasis, from the database in the Advanced Lung/Interstitial Lung Disease Program at the Mount Sinai Hospital. Read More

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https://www.hindawi.com/journals/crj/2019/5919304/
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http://dx.doi.org/10.1155/2019/5919304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732645PMC
May 2020
2 Reads
1.663 Impact Factor