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    1306 results match your criteria Canadian Respiratory Journal[Journal]

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    Pretreatment Hemoglobin Level Is an Independent Prognostic Factor in Patients with Lung Adenocarcinoma.
    Can Respir J 2018 15;2018:6328127. Epub 2018 May 15.
    Department of Oncology, Huaihe Hospital of Henan University, Kaifeng 475001, China.
    Background/aim: Few studies have reported the prognostic value of pretreatment hemoglobin levels in patients with lung adenocarcinoma (LA). In the present study, we retrospectively reviewed 306 LA patients for their prognosis associated with the pretreatment hemoglobin levels.

    Methods: Person-years and case fatality rate (CFR) were calculated from May 2010 to June 2017. Read More

    EZH2 Inhibition Ameliorates Transverse Aortic Constriction-Induced Pulmonary Arterial Hypertension in Mice.
    Can Respir J 2018 28;2018:9174926. Epub 2018 Feb 28.
    Department of Intensive Care Unit, Hangzhou Red Cross Hospital/Zhejiang Chinese Medicine, Western Medicine Integrated Hospital, Hangzhou 310003, China.
    Background: EPZ005687 is a selective inhibiter of methyltransferase EZH2. In this article, we investigated the protective role and mechanism of EPZ005687 in transverse aortic constriction-induced pulmonary arterial hypertension in mice.

    Methods: We assigned 15 (6-8 weeks old) male balb/c mice to 3 groups randomly: Sham control + DMSO group, TAC + DMSO group, and TAC + EPZ005687 group (10 mg kg, once a week for 4 weeks). Read More

    Model for Developing a Health-Related Quality of Life Questionnaire for Chronic Obstructive Pulmonary Disease.
    Can Respir J 2018 2;2018:6450962. Epub 2018 May 2.
    Faculty of Philosophy, University of Montenegro, 81000 Podgorica, Montenegro.
    Introduction: The St. George's Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) Dyspnea Scale, Hospital Anxiety and Depression Scale (HADS), and general health questionnaire (SF-36) are widely used for chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD).

    Aim: We examined the reliability and validity of a modified questionnaire (MQ) to create a model for assessing the health-related quality of life (HRQOL) in COPD. Read More

    Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice.
    Can Respir J 2018 2;2018:5259240. Epub 2018 May 2.
    Department of Pediatrics, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.
    Background And Objective: While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction with budesonide.

    Methods: A mouse model of asthma was established by allergic sensitization and challenge with ovalbumin. Read More

    Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control.
    Can Respir J 2018 8;2018:4835823. Epub 2018 May 8.
    Medical Informatics Research Laboratory of the Higher School of Information Technologies and Information Systems, Kazan Federal University, 18 Kremlyovskaya St., Kazan, Republic of Tatarstan 420008, Russia.
    Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8. Read More

    Transition from Ambrisentan to Bosentan in Pulmonary Arterial Hypertension: A Single-Center Prospective Study.
    Can Respir J 2018 11;2018:9836820. Epub 2018 Apr 11.
    Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
    : Two endothelin receptor antagonists (ETRAs), bosentan and ambrisentan, are approved for patients with pulmonary arterial hypertension (PAH). However, there is little information about the transition strategy between these two ETRAs. We aimed to evaluate the safety and efficacy from ambrisentan to bosentan. Read More

    ELISA Development for Serum Hemeoxygenase-1 and Its Application to Patients with Acute Respiratory Distress Syndrome.
    Can Respir J 2018 18;2018:9627420. Epub 2018 Apr 18.
    Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Background: Hemeoxygenase-1 (HO-1) is an essential enzyme in heme catabolism and has been proposed as a biomarker of lung disease prognosis. We modified a commercial HO-1 enzyme-linked immunosorbent assay (ELISA) kit to achieve higher sensitivity and evaluated if serum HO-1 could be a biomarker to predict the prognosis of acute respiratory distress syndrome (ARDS) patients.

    Methods: Serum samples were collected from 15 healthy volunteers to validate the modified ELISA. Read More

    Verification of a Motion Sensor for Evaluating Physical Activity in COPD Patients.
    Can Respir J 2018 23;2018:8343705. Epub 2018 Apr 23.
    Department of Clinical Laboratory, National Hospital Organization Wakayama Hospital, 1138 Wada Mihama-cho, Hidaka-gun, Wakayama 644-0044, Japan.
    Background: Objective evaluation of the physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) is important. We validated a triaxial accelerometer, Active Style Pro HJA-750C® (HJA), and evaluated the necessary conditions for obtaining reproducible data.

    Methods: The PA measured by HJA was compared with that measured by two already validated accelerometers in 11 patients with COPD (age: 76. Read More

    Positive Sputum PCR Results with Negative Bronchoscopic PCR Results in Suspected Pneumocystis Pneumonia.
    Can Respir J 2018 3;2018:6283935. Epub 2018 Apr 3.
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
    Introduction: The diagnostic standard for pneumonia (PCP) is direct microscopic identification; however, in recent years, polymerase chain reaction (PCR) from bronchoalveolar lavage (BAL) samples to detect nucleic acids has proven to be more sensitive and specific. Sputum samples have been presumed inferior to bronchoscopic samples secondary to variability and adequacy of sample collection. We observed several cases of positive sputum PCP-PCR results with negative PCP-PCR BAL results. Read More

    Chronic Intermittent Hypoxia Induces the Long-Term Facilitation of Genioglossus Corticomotor Activity.
    Can Respir J 2018 23;2018:5941429. Epub 2018 Apr 23.
    Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, China.
    Obstructive sleep apnea (OSA) is characterized by the repetitive collapse of the upper airway and chronic intermittent hypoxia (CIH) during sleep. It has been reported that CIH can increase the EMG activity of genioglossus in rats, which may be related to the neuromuscular compensation of OSA patients. This study aimed to explore whether CIH could induce the long-term facilitation (LTF) of genioglossus corticomotor activity. Read More

    Optimizing the Delivery of Inhaled Medication for Respiratory Patients: The Role of Valved Holding Chambers.
    Can Respir J 2018 4;2018:5076259. Epub 2018 Apr 4.
    Family Physician Airways Group of Canada, Richmond Hill, ON, Canada.
    Valved holding chambers (VHCs) have been used with pressurized metered-dose inhalers since the early 1980s. They have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce side effects such as throat irritation, dysphonia, and oral candidiasis that are common with use of pressurized metered-dose inhalers (pMDIs) alone. VHCs act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a two-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation. Read More

    Comparison of Respiratory Pathogen Detection in Upper versus Lower Respiratory Tract Samples Using the BioFire FilmArray Respiratory Panel in the Immunocompromised Host.
    Can Respir J 2018 5;2018:2685723. Epub 2018 Apr 5.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Background: The FilmArray Respiratory Panel (FARP) (BioFire Diagnostics, Inc.) is a multiplex, polymerase chain reaction (PCR) technique that can detect 17 respiratory viruses and 3 bacterial targets in a single reaction. Immunocompromised hosts (ICH) with respiratory illnesses often undergo bronchoscopy with bronchoalveolar lavage (BAL). Read More

    Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography.
    Can Respir J 2018 1;2018:9649716. Epub 2018 Apr 1.
    Department of Internal Medicine V, Ludwig-Maximilians-University of Munich, Munich, Germany.
    Chronic hypoxia causes pulmonary vascular remodeling resulting in persistently increased pulmonary arterial pressures (PAP) even after return to normoxia. Recently, interest in chronic intermittent hypobaric hypoxia (CIHH) was raised because it occurs in subjects working at high altitude (HA) but living in lowland. However, effects of daily CIHH on PAP are unknown. Read More

    The Function of in Airway Epithelial Cell Senescence in a Rat COPD Model.
    Can Respir J 2018 1;2018:6080348. Epub 2018 Apr 1.
    Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
    () seems to be able to alleviate airway epithelial cell senescence in chronic obstructive pulmonary disease (COPD). The objective of the study is to evaluate the effect of on airway epithelial senescence in the COPD model both in vitro and in vivo. We observed the expression of P16 and P21 in the airway epithelia of 30 patients with COPD. Read More

    Clinical and Functional Characteristics of Subjects with Asthma, COPD, and Asthma-COPD Overlap: A Multicentre Study in Vietnam.
    Can Respir J 2018 1;2018:1732946. Epub 2018 Apr 1.
    Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA, USA.
    Introduction: Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients.

    Subjects And Methods: Study subjects who met the inclusion criteria were classified into three different groups: asthma, COPD, and ACO groups. Read More

    Effects of Habenular Stimulation Frequencies on Obstructive Sleep Apnea Induced by Stimulation of Insular Cortex.
    Can Respir J 2018 26;2018:9060678. Epub 2018 Mar 26.
    The First Affiliated Hospital of Jilin University, Changchun 130021, China.
    Objective: To investigate the effects of high-frequency stimulation of the habenula (Hb) on obstructive sleep apnea (OSA) induced by stimulation of the insular cortex . After OSA was induced by stimulating the insular cortex (Ic) with concentric stimulating electrodes at 100 Hz in rats, the Hb was stimulated at different frequencies (50 Hz, 120 Hz, 130 Hz, and 280 Hz). The changes of apnea events and electromyography (EMG) of the genioglossus were compared before and after stimulation of the Hb. Read More

    Effects of Fasudil on Patients with Pulmonary Hypertension Associated with Left Ventricular Heart Failure with Preserved Ejection Fraction: A Prospective Intervention Study.
    Can Respir J 2018 26;2018:3148259. Epub 2018 Mar 26.
    Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Background: Pulmonary hypertension due to left ventricular heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly medical problem. The aim of the study was to evaluate the clinical efficacy of fasudil on PH-HFpEF elderly patients and to figure out the subtype of PH-HFpEF which may be the therapeutic object of fasudil.

    Method: 58 PH-HFpEF elderly patients were enrolled. Read More

    Asthma Control and Asthma Medication Use among Swedish Elite Endurance Athletes.
    Can Respir J 2018 18;2018:4646852. Epub 2018 Mar 18.
    Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Östersund, Umeå, Sweden.
    Background: Asthma is common in elite athletes. In this study, we examined the use of asthma medication and asthma control in endurance athletes in Sweden and compared the findings with those in a reference group of patients with asthma.

    Methods: The Asthma Control Test (ACT) and a questionnaire on asthma, respiratory symptoms, and medication use were posted to endurance athletes (=711) and the reference group of patients with asthma (=1026). Read More

    Chest Ultrasonography in Modern Day Extreme Settings: From Military Setting and Natural Disasters to Space Flights and Extreme Sports.
    Can Respir J 2018 15;2018:8739704. Epub 2018 Mar 15.
    Dipartmento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy.
    Chest ultrasonography (CU) is a noninvasive imaging technique able to provide an immediate diagnosis of the underlying aetiology of acute respiratory failure and traumatic chest injuries. Given the great technologies, it is now possible to perform accurate CU in remote and adverse environments including the combat field, extreme sport settings, and environmental disasters, as well as during space missions. Today, the usage of CU in the extreme emergency setting is more likely to occur, as this technique proved to be a fast diagnostic tool to assist resuscitation manoeuvres and interventional procedures in many cases. Read More

    Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
    Can Respir J 2018 13;2018:3629031. Epub 2018 Mar 13.
    Clinique de fibrose kystique, Centre hospitalier de l'Université de Montréal (CHUM), 1051 rue Sanguinet, Montréal, QC, Canada H2X 0C1.
    Background: The prevalence of adrenal insufficiency (AI) in cystic fibrosis (CF) is unknown. The frequent use of glucocorticoids (inhaled or systemic) may induce the long-term suppression of the hypothalamic-pituitary-adrenal axis.

    Methods: We reviewed the results of adrenocorticotropic hormone (ACTH) stimulation tests done over a 10-year period to evaluate adrenal function in 69 CF patients of the CHUM CF clinic. Read More

    Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease.
    Can Respir J 2018 4;2018:9493504. Epub 2018 Mar 4.
    Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
    Objectives: Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. Read More

    Endobronchial Ultrasound Transbronchial Needle Aspiration in Thoracic Diseases: Much More than Mediastinal Staging.
    Can Respir J 2018 4;2018:4269798. Epub 2018 Mar 4.
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy.
    Background And Objective: EBUS-TBNA has revolutionized the diagnostic approach to thoracic diseases from a surgical to minimally invasive procedure. In non small-cell lung cancer (NCSLC) patients, EBUS-TBNA is able to dictate the consecutive therapy both for early and advanced stages, providing pathological diagnosis, mediastinal staging, and even adequate specimens for molecular analysis. This study reports on the ability of EBUS-TBNA to make different diagnoses and dictates the consecutive therapy in a large cohort of patients presenting different thoracic diseases. Read More

    Cost Analysis of Noninvasive Helmet Ventilation Compared with Use of Noninvasive Face Mask in ARDS.
    Can Respir J 2018 8;2018:6518572. Epub 2018 Feb 8.
    University of Chicago Medicine, Chicago, IL, USA.
    Intensive care unit (ICU) costs have doubled since 2000, totalling 108 billion dollars per year. Acute respiratory distress syndrome (ARDS) has a prevalence of 10.4% and a 28-day mortality of 34. Read More

    ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis.
    Can Respir J 2018 21;2018:5712805. Epub 2018 Jan 21.
    The Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
    Background: The beta-2 adrenergic receptor (ADRB2) Arg16Gly polymorphism may alter the bronchodilation response to long-acting beta2-agonists, thereby influencing the clinical effectiveness of LABAs plus corticosteroids (ICS) treatment. But the results of individual studies are inconclusive.

    Methods: A systematic search was conducted in PubMed, Embase, the Cochrane Database, WHO International Clinical Trials Registry Platform, Chinese National Knowledge Infrastructure, Wanfang, Chinese BioMedical Literature Database, and VIP databases. Read More

    Tiotropium for the Treatment of Asthma: Patient Selection and Perspectives.
    Can Respir J 2018 21;2018:3464960. Epub 2018 Jan 21.
    McMaster University, Firestone Institute for Respiratory Health, Hamilton, ON, Canada.
    Asthma is a chronic disease of airway inflammation with a large global burden. Despite established, guideline-based stepwise therapy, a significant proportion of patients remain symptomatic and poorly controlled. As such, there is a need for additional safe, effective, convenient, and cost-effective therapies that can be broadly applied across a range of asthma phenotypes. Read More

    PM2.5 Induced the Expression of Fibrogenic Mediators via HMGB1-RAGE Signaling in Human Airway Epithelial Cells.
    Can Respir J 2018 28;2018:1817398. Epub 2018 Jan 28.
    The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
    Background: The aim of the present study was to test whether fine particulate matter (PM2.5) induces the expression of platelet-derived growth factor-AB (PDGF-AB), PDGF-BB, and transforming growth factor-1 (TGF-1) in human bronchial epithelial cells (HBECs) in vitro via high-mobility group box 1 (HMGB1) receptor for advanced glycation end products (RAGE) signaling.

    Methods: Sprague-Dawley rats were exposed to motor vehicle exhaust (MVE) or clean air. Read More

    The Effects of Continuous Positive Airway Pressure on Premature Ventricular Contractions and Ventricular Wall Stress in Patients with Heart Failure and Sleep Apnea.
    Can Respir J 2018 7;2018:2027061. Epub 2018 Feb 7.
    Department of Chest Disease, Live Istinye University Hospital, Istanbul, Turkey.
    Background: We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure.

    Methods: Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment. To compare the impact of CPAP on ECG parameters, both baseline and 6-month ECG, 24-hour Holter ECG, ambulatory blood pressure monitoring, echocardiography, polysomnography, and laboratory parameters were collected. Read More

    Comparison of Mask Oxygen Therapy and High-Flow Oxygen Therapy after Cardiopulmonary Bypass in Obese Patients.
    Can Respir J 2018 28;2018:1039635. Epub 2018 Jan 28.
    Department of Anesthesia and Reanimation, Haseki Teaching and Research Hospital, Istanbul, Turkey.
    Background: To clarify the efficiency of mask O and high-flow O (HFO) treatments following cardiopulmonary bypass (CPB) in obese patients.

    Methods: During follow-up, oxygenization parameters including arterial pressure of oxygen (PaO), peripheral oxygen saturation (SpO), and arterial partial pressure of carbon dioxide (PaCO) and physical examination parameters including respiratory rate, heart rate, and arterial pressure were recorded respectively. Presence of atelectasia and dyspnea was noted. Read More

    Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study.
    Can Respir J 2018 22;2018:6746470. Epub 2018 Jan 22.
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
    Background: The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope.

    Methods: In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using flexible forceps and flexible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB). Read More

    Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease.
    Can Respir J 2018 23;2018:3640967. Epub 2018 Jan 23.
    Department of Pulmonary Medicine, St. Luke's International University, St. Luke's International Hospital, Tokyo, Japan.
    Background: Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data.

    Methods: We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Read More

    Approach to Hemoptysis in the Modern Era.
    Can Respir J 2017 21;2017:1565030. Epub 2017 Dec 21.
    Institut Universitaire de Pneumologie et de Cardiologie de Québec, 2725 Ch Ste-Foy, Quebec City, QC, Canada G1V 4G5.
    Hemoptysis is a frequent manifestation of a wide variety of diseases, with mild to life-threatening presentations. The diagnostic workup and the management of severe hemoptysis are often challenging. Advances in endoscopic techniques have led to different new therapeutic approaches. Read More

    Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation.
    Can Respir J 2017 17;2017:9480346. Epub 2017 Dec 17.
    Critical Care and Acute Care Surgery Division, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
    We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation. We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia. Read More

    Investigation on Risk Factors of Ventilator-Associated Pneumonia in Acute Cerebral Hemorrhage Patients in Intensive Care Unit.
    Can Respir J 2017 17;2017:7272080. Epub 2017 Dec 17.
    Department of Emergency Intensive Care Unit, Sichuan Province People's Hospital, Chengdu, Sichuan, China.
    Ventilator-associated pneumonia (VAP) is a predominant factor of pulmonary infection. We analyzed the risk factors of VAP with acute cerebral hemorrhage in intensive care unit (ICU) by univariate and multivariate logistic regression analyses. After comparison of 197 cases of the VAP and non-VAP patients, we found that age > 65 years ( = 0. Read More

    Burden of Respiratory Syncytial Virus Hospitalizations in Canada.
    Can Respir J 2017 7;2017:4521302. Epub 2017 Nov 7.
    AbbVie, Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA.
    Objective: To examine the socioeconomic burden of respiratory syncytial virus (RSV) disease for Canadian infants hospitalized for the condition.

    Data And Methods: The descriptive study used data collected in Alberta, Canada, during 2 consecutive RSV seasons. Infants (<1 year of age) were included if they had not received palivizumab and were hospitalized with a confirmed diagnosis of RSV. Read More


    Is There a Correlation between New Scoring Systems and Systemic Inflammation in Stable Bronchiectasis?
    Can Respir J 2017 15;2017:9874068. Epub 2017 Nov 15.
    Department of Chest Disease, Istinye University Istanbul, Istanbul, Turkey.
    Aim: The present study aimed to investigate the relation between FACED and BSI scores, which were developed to measure the severity of bronchiectasis, and systemic inflammation in patients with stable bronchiectasis.

    Methods: FACED and BSI scores of 117 patients with stable bronchiectasis were calculated. The correlations between mean scores and CRP levels, leukocyte count, and neutrophil/lymphocyte ratio were investigated. Read More

    Feasibility of Radial Endobronchial Ultrasound-Guided Bronchoscopic Cryobiopsy without Fluoroscopy for Lung Parenchymal Lesions.
    Can Respir J 2017 15;2017:7170687. Epub 2017 Nov 15.
    Department of Pulmonary and Critical Care Medicine, Linkou Chang Gung Memorial Hospital, and Chang Gung University, Taoyuan, Taiwan.
    Background: Cryobiopsy is used to biopsy peripheral lung lesions through flexible bronchoscopy with fluoroscopic guidance. However, fluoroscopy is not available at some institutions. This study evaluated the feasibility of radial endobronchial ultrasound-guided bronchoscopic cryobiopsy without fluoroscopy. Read More

    Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients.
    Can Respir J 2017 13;2017:3685261. Epub 2017 Nov 13.
    Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China.
    Background: We evaluated the utility of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for the diagnosis of invasive pulmonary aspergillosis (IPA) in nonneutropenic patients.

    Methods: A total of 183 patients were included in the final analysis. Bronchoscopies and the detection of GM in BALF were all performed on them. Read More

    Hypercapnic Ventilatory Response in the Weaning of Patients with Prolonged Mechanical Ventilation.
    Can Respir J 2017 30;2017:7381424. Epub 2017 Oct 30.
    Department of Pulmonary and Critical Care Medicine, Xiamen Chang Gung Hospital, Xiamen City, China.
    Objective: To investigate whether hypercapnic ventilatory response (defined as the ratio of the change in minute ventilation [[Formula: see text]] to the change in end-tidal partial pressure of carbon dioxide [Δ ]) is a predictor of successful weaning in patients with prolonged mechanical ventilation (PMV) and to determine a reference value for clinical use.

    Methods: A hypercapnic challenge test was performed on 32 PMV subjects (average age: 74.3 years ± 14. Read More

    Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy.
    Can Respir J 2017 23;2017:1602039. Epub 2017 Oct 23.
    Department of Pulmonology, Semmelweis University, Budapest, Hungary.
    Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Read More

    Future Directions and Molecular Basis of Ventilator Associated Pneumonia.
    Can Respir J 2017 15;2017:2614602. Epub 2017 Oct 15.
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. Read More

    The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model.
    Can Respir J 2017 28;2017:8530352. Epub 2017 Sep 28.
    Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, Beijing 100035, China.
    Background And Objective: TWIK-related acid-sensitive potassium channel 1 (TASK-1) is closely related to respiratory central control and neuronal injury. We investigated the effect of MV on TASK-1's functions and explored the mechanism using a rat model.

    Methods: Male Sprague-Dawley rats were randomized to three groups: (1) high tidal volume (HVt): MV for four hours with Vt at 10 mL/kg; (2) low Vt (LVt): MV for four hours with Vt at 5 mL/kg; (3) basal (BAS): anesthetized and unventilated animals. Read More

    Rainfall-Associated Bronchospasm Epidemics: The Epidemiological Effects of Air Pollutants and Weather Variables.
    Can Respir J 2017 27;2017:9252069. Epub 2017 Sep 27.
    Nursing and Emergency Department, Dezful University of Medical Sciences, Dezful, Iran.
    Background: This study compares different risk factors in patients visiting a hospital during five rainfall-associated bronchospasm epidemics in Ahvaz and those visiting on other occasions.

    Methods: This case-control study was conducted on 5307 patients with bronchospasm admitted to the Emergency Department of Imam Khomeini Hospital in Ahvaz (Iran) from late October to December (as the epidemic) and 916 patients admitted from late January to March (as the nonepidemic) in 2011 to 2015.

    Results: A total of the 41. Read More

    Impaired Hemorheology in Exacerbations of COPD.
    Can Respir J 2017 27;2017:1286263. Epub 2017 Sep 27.
    Faculty of Medicine, Department of Physiology, Pamukkale University, Denizli, Turkey.
    Background: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. Read More

    Occupational Exposure to Talc Increases the Risk of Lung Cancer: A Meta-Analysis of Occupational Cohort Studies.
    Can Respir J 2017 31;2017:1270608. Epub 2017 Aug 31.
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
    Objective: Talc is widely used in industrial applications. Previous meta-analyses of carcinogenic effects associated with inhaled talc included publications before 2004, with a lack of data in China, the largest talc-producing country. The safety of workers exposed to talc was unclear due to limited evidence. Read More

    Safety and Performance Characteristics of Outpatient Medical Thoracoscopy and Indwelling Pleural Catheter Insertion for Evaluation and Diagnosis of Pleural Disease at a Tertiary Center in Canada.
    Can Respir J 2017 30;2017:9345324. Epub 2017 Aug 30.
    Department of Medicine, Division of Respirology, University of Ottawa, Ottawa, ON, Canada.
    Background: Many centers performing medical thoracoscopy (MT) to diagnose pleural disease will insert a chest tube and admit patients to hospital after the procedure, which is inconvenient for patients and contributes to healthcare costs. We report the data on the safety, outcomes, and performance characteristics of outpatient MT with indwelling pleural catheter (IPC) insertion in a large Canadian cohort.

    Methods: This retrospective cohort study reviewed patients who underwent outpatient MT and IPC insertion under conscious sedation. Read More

    Mechanical Circulatory Support as a Bridge to Lung Transplantation: A Single Canadian Institution Review.
    Can Respir J 2017 29;2017:5947978. Epub 2017 Aug 29.
    Department of Surgery, Division of Cardiac Surgery, Edmonton, AB, Canada.
    Background: Lung transplant (LTx) waitlists continue to grow internationally. Consequently, more patients are progressing to require mechanical circulatory support (MCS) as a bridge to transplantation (BTT). MCS strategies include interventional lung assist (iLA) and venovenous (VV) and venoarterial (VA) extracorporeal membrane oxygenation (ECMO). Read More

    Readability and Suitability of COPD Consumer Information.
    Can Respir J 2017 29;2017:2945282. Epub 2017 Aug 29.
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
    Background: Information leaflets have been shown to positively or negatively impact adherence, depending on their content. The objective of this study was to perform an appraisal of the consumer information provided in COPD inhaler monographs.

    Methods: COPD inhalers were identified from the Health Canada Drug Product Database. Read More

    Preliminary Results of the Adoption and Application of the Integrated Comprehensive Care Bundle Care Program When Treating Patients with Chronic Obstructive Pulmonary Disease.
    Can Respir J 2017 7;2017:7049483. Epub 2017 Aug 7.
    Programs for Assessment of Technology in Health, The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
    Background: St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary obstructive disease (COPD). Read More

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