126,998 results match your criteria Canadian Modern Language Review-revue Canadienne Des Langues Vivantes[Journal]


Occupational Performance Outcome for Survivors of Childhood Cancer: Feasibility of the Canadian Occupational Performance Measure.

Occup Ther Health Care 2020 Jun 3:1-13. Epub 2020 Jun 3.

Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.

The aim of the study was to determine the feasibility of the Persian version of the Canadian Occupational Performance Measure (COPM) to assess self-reported occupational performance in a group of children with cancer at least one-year post-cancer diagnosis and intervention and to describe the self-reported occupational performance problems of children with cancer. Forty-three children with cancer (mean age 11.59 years; SD 4. Read More

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http://dx.doi.org/10.1080/07380577.2020.1773011DOI Listing

Documenting change with the Canadian Occupational Performance Measure for children with cerebral palsy.

Dev Med Child Neurol 2020 Jun 3. Epub 2020 Jun 3.

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Aim: To assess the Canadian Occupational Performance Measure's (COPM) ability to document change over 3 years in children with cerebral palsy (CP).

Method: This was a prospective study with ambulatory children with CP, aged 2 to 6 years. Caregivers set one to three COPM goals which were rescored annually over 3 years. Read More

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http://dx.doi.org/10.1111/dmcn.14569DOI Listing

Using concept mapping to explore the challenges associated with affording and accessing medications among people living with HIV in Ontario, Canada.

AIDS Care 2020 Jun 3:1-6. Epub 2020 Jun 3.

Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Antiretroviral medications are expensive, and people living with HIV often experience challenges accessing and paying for medication due to various obstacles. We used concept mapping to explore the challenges people living with HIV in Ontario, Canada, face when accessing medication. In brainstorming, 68 participants generated 447 statements in response to the focus prompt "Some people living with HIV have trouble getting and paying for prescription drugs because … ". Read More

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http://dx.doi.org/10.1080/09540121.2020.1770182DOI Listing

Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study.

Phys Chem Chem Phys 2020 Jun 3. Epub 2020 Jun 3.

Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.

Adenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods. Read More

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http://dx.doi.org/10.1039/d0cp00797hDOI Listing

Incidence and severity of Visually Induced motion Sickness during 3D laparoscopy In Operators who had No experience with it (VISION).

Wideochir Inne Tech Maloinwazyjne 2020 Jun 20;15(2):283-289. Epub 2020 Apr 20.

Department of Thoracic and Cardiovascular Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (South).

Aim: The aim of the study was to evaluate the incidence and severity of visually induced motion sickness (VIMS) during 3D laparoscopy, in operators without prior experience.

Material And Methods: Design: A retrospective comparative study (Canadian Task Force classification II-2). Setting: A university hospital. Read More

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http://dx.doi.org/10.5114/wiitm.2020.94347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233166PMC

The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity.

Ann Thorac Med 2020 Apr-Jun;15(2):70-75. Epub 2020 Apr 3.

Somnogen Canada Inc., Toronto, ON, Canada.

Objective: Currently accepted guidelines categorize obstructive sleep apnea (OSA) severity according to the Apnea-Hypopnea Index (AHI). However, it is unclear how to best define OSA severity. The present study sought to evaluate the concurrent validity of the widely accepted AHI by correlating it with various oxygen saturation (SpO) and polysomnographic parameters. Read More

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http://dx.doi.org/10.4103/atm.ATM_215_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259396PMC

Updates from the American Society of Hematology 2019 annual meeting: practice-changing studies in treatment-naïve chronic lymphocytic leukemia.

Curr Oncol 2020 Apr 1;27(2):e231-e245. Epub 2020 May 1.

McGill University Health Centre, Montreal, QC.

The 2019 annual meeting of the American Society of Hematology took place 7-10 December in Orlando, Florida. At the meeting, results from key studies in treatment-naïve chronic lymphocytic leukemia (cll) were presented. Of those studies, phase iii oral presentations focused on the efficacy and safety of therapy with inhibitors of Bruton tyrosine kinase (btk) and Bcl-2. Read More

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http://dx.doi.org/10.3747/co.27.6291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253738PMC

The Canadian Cancer Research Conference 2019.

Curr Oncol 2020 Apr 1;27(2):e226-e230. Epub 2020 May 1.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON.

The 5th Canadian Cancer Research Conference (ccrc) took place 3-5 November 2019 in Ottawa, Ontario. Nearly 1000 participants-scientists, oncologists, community members, and patients-gathered to share knowledge, foster collaboration, and fuel the future of cancer research in Canada. The scientific program included 3 plenary sessions, 26 concurrent sessions, and 2 poster sessions presenting research described in more than 600 submitted abstracts, giving participants the opportunity to share health research that collectively encompassed the 4 pillars recognized by the Canadian Institutes of Health Research. Read More

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http://dx.doi.org/10.3747/co.27.6245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253731PMC

A population-based analysis of breast cancer incidence and survival by subtype in Ontario women.

Curr Oncol 2020 Apr 1;27(2):e191-e198. Epub 2020 May 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON.

Background: Breast cancer (bca) is the type of cancer most frequently diagnosed among women in Canada. Breast cancer is categorized into various molecular subtypes by the expression of estrogen receptor (er), progesterone receptor (pgr), and her2 (human epidermal growth factor receptor 2). Currently, Canada has no national cancer registry with epidemiology data by subtype. Read More

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http://dx.doi.org/10.3747/co.27.5769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253754PMC

Germline variants and phenotypic spectrum in a Canadian cohort of individuals with diffuse gastric cancer.

Curr Oncol 2020 Apr 1;27(2):e182-e190. Epub 2020 May 1.

Sinai Health System, Department of Surgery, University of Toronto, Toronto, ON.

Background: pathogenic variants (pvs) cause most cases of inherited diffuse gastric cancer (dgc), but have low detection rates and vary geographically. In the present study, we examined hereditary causes of dgc in patients in Ontario.

Methods: testing through single-site or multi-gene panels was conducted for patients with dgc meeting the 2015 International Gastric Cancer Linkage Consortium (igclc) criteria, or with isolated dgc at less than 50 years of age, or with a strong family history of cancer identified at the Zane Cohen Centre (zcc). Read More

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http://dx.doi.org/10.3747/co.27.5663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253747PMC

Translating guidelines to practice: a training session about cancer-related fatigue.

Curr Oncol 2020 Apr 1;27(2):e163-e170. Epub 2020 May 1.

School of Psychology, University of Ottawa, Ottawa, ON.

Background: Cancer-related fatigue (crf) is the highest unmet need in cancer survivors. The Canadian Association of Psychosocial Oncology (capo) has developed guidelines for screening, assessment, and intervention in crf; however, those guidelines are not consistently applied in practice because of patient, health care provider (hcp), and systemic barriers. Notably, previous studies have identified a lack of knowledge of crf guidelines as an impediment to implementation. Read More

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http://dx.doi.org/10.3747/co.27.5681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253734PMC

Canadian consensus: a new systemic treatment algorithm for advanced mutated non-small-cell lung cancer.

Curr Oncol 2020 Apr 1;27(2):e146-e155. Epub 2020 May 1.

William Osler Health System, University of Toronto, Brampton, ON.

Background: Multiple clinical trials for the treatment of advanced mutated non-small-cell lung cancer (nsclc) have recently been reported. As a result, the treatment algorithm has changed, and many important clinical questions have been raised:■ What is the optimal first-line treatment for patients with mutated nsclc?■ What is preferred first-line treatment for patients with brain metastasis?■ What is the preferred second-line treatment for patients who received first-line first- or second-generation tyrosine kinase inhibitors (tkis)?■ What is the preferred treatment after osimertinib?■ What evidence do we have for treating patients whose tumours harbour uncommon mutations?

Methods: A Canadian expert panel was convened to define the key clinical questions, review recent evidence, and discuss and agree on practice recommendations for the treatment of advanced mutated nsclc.

Results: The published overall survival results for osimertinib, combined with its central nervous system activity, have led to osimertinib becoming the preferred first-line treatment for patients with common mutations, including those with brain metastasis. Read More

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http://dx.doi.org/10.3747/co.27.6007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253730PMC

Nonsurgical management of advanced hepatocellular carcinoma: a clinical practice guideline.

Curr Oncol 2020 Apr 1;27(2):e106-e114. Epub 2020 May 1.

Princess Margaret Cancer Centre, Toronto, ON.

Background: Practice guidelines based on a systematic review of the literature regarding the nonsurgical management of hepatocellular carcinoma (hcc) in North America are lacking. Resection and transplantation are the foundations for cure of hcc; however, most patients are diagnosed at an advanced stage, precluding those curative treatments. A number of local or regional therapies are used and are followed by systemic therapy for advanced or progressive disease. Read More

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http://dx.doi.org/10.3747/co.27.5891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253733PMC

Update on the subcutaneous administration of rituximab in Canadian cancer centres.

Curr Oncol 2020 Apr 1;27(2):113-116. Epub 2020 May 1.

Hoffmann-La Roche, Mississauga, ON.

Results of studies comparing subcutaneous (sc) with intravenous (iv) rituximab indicate that the two formulations are comparable in efficacy, but most patients and health care professionals prefer the sc route, commonly because of shorter chair time and reduced risk of infusion-related reactions. Recent Canadian data, including those from the scuba study reported here, support the results of earlier international studies showing a reduction in preparation and administration time with the sc formulation, lower cost of administration, and reduced drug wastage because of the fixed sc dosing. Given the significant time and cost savings of the sc formulation, that formulation is generally preferred over the iv formulation for the treatment of follicular lymphoma, diffuse large B cell lymphoma, and chronic lymphocytic leukemia. Read More

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http://dx.doi.org/10.3747/co.27.6041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253745PMC

Radiotherapy side effects: integrating a survivorship clinical lens to better serve patients.

Curr Oncol 2020 Apr 1;27(2):107-112. Epub 2020 May 1.

Department of Oncology, Division of Radiation Oncology, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC.

The Canadian Cancer Society estimated that 220,400 new cases of cancer would be diagnosed in 2019. Of the affected patients, more than 60% will survive for 5 years or longer after their cancer diagnosis. Furthermore, nearly 40% will receive at least 1 course of radiotherapy (rt). Read More

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http://dx.doi.org/10.3747/co.27.6233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253739PMC

A catalyst for transforming health systems and person-centred care: Canadian national position statement on patient-reported outcomes.

Curr Oncol 2020 Apr 1;27(2):90-99. Epub 2020 May 1.

Alberta: Department of Oncology, University of Calgary, Calgary (Barbera, Bebb, Cheung); University of Calgary, Calgary (Crump, Temple); Departments of Surgery and Oncology, University of Calgary, Calgary (McKinnon); Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary (Pink, Santana); University of Calgary and Tom Baker Cancer Centre, Calgary (Robinson); Faculty of Nursing, University of Calgary, Calgary (Sinclair).

Background: Patient-reported outcomes (pros) are essential to capture the patient's perspective and to influence care. Although pros and pro measures are known to have many important benefits, they are not consistently being used and there is there no Canadian pros oversight. The Position Statement presented here is the first step toward supporting the implementation of pros in the Canadian health care setting. Read More

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http://dx.doi.org/10.3747/co.27.6399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253746PMC

Impact of COVID-19 on Canadian medical oncologists and cancer care: Canadian Association of Medical Oncologists survey report.

Curr Oncol 2020 04 1;27(2):71-74. Epub 2020 May 1.

Dalhousie University, Halifax, NS.

Background: The covid-19 pandemic has presented unprecedented professional and personal challenges for the oncology community. Under the auspices of the Canadian Association of Medical Oncologists, we conducted an online national survey to better understand the impact of the pandemic on the medical oncology community in Canada.

Methods: An English-language multiple-choice survey, including questions about demographics, covid-19 risk, use of personal protective equipment (ppe), personal challenges, and chemotherapy management was distributed to Canadian medical oncologists. Read More

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http://dx.doi.org/10.3747/co.27.6643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253737PMC

Policymaker and stakeholder perspectives on access to assistive technologies in Canada: challenges and proposed solutions for enhancing equitable access.

Disabil Rehabil Assist Technol 2020 Jun 3:1-13. Epub 2020 Jun 3.

McMaster Health Forum, McMaster University, Hamilton, Canada.

Unmet needs for assistive technologies (ATs) exist and the need for ATs is growing owing to demographic changes worldwide. Little comprehensive research has examined equity of access to ATs in Canada. Our study elucidates perspectives of policymakers and stakeholders on challenges and solutions for enhancing equitable access to ATs to advance policy discussions. Read More

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http://dx.doi.org/10.1080/17483107.2020.1765033DOI Listing

Implementation of an in-patient hip fracture liaison services to improve initiation of osteoporosis medication use within 1-year of hip fracture: a population-based time series analysis using the RE-AIM framework.

Arch Osteoporos 2020 Jun 2;15(1):83. Epub 2020 Jun 2.

University of Alberta (Medicine), Edmonton, AB, Canada.

A hip fracture liaison service that was implemented in 2 hospitals in Alberta, Canada, co-managed by a nurse and physician, was effective for improving initiation of osteoporosis medication following hip fracture.

Purpose: To examine implementation of an in-patient hip fracture liaison service (H-FLS) to improve osteoporosis medication use after hip fracture using the RE-AIM framework (reach, effectiveness, adoption, implementation, maintenance).

Methods: Using population-based administrative data from 7 quarters before and up to 7 quarters after H-FLS implementation, we examined new starts, continued use, and overall use (new starts + continued use) of osteoporosis medication after hip fracture. Read More

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http://dx.doi.org/10.1007/s11657-020-00751-2DOI Listing

Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.

Sci Rep 2020 Jun 2;10(1):8982. Epub 2020 Jun 2.

Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, H1T 2M4, Canada.

The binder of sperm family of proteins has been reported to be indispensable for sperm maturation and capacitation. However, their physiological functions in fertility have only been studied in vitro. CRISPR/Cas9 genome editing was utilized to generate double knockout (DKO) mice by simultaneously targeting the two murine binder of sperm genes, Bsph1 and Bsph2. Read More

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http://dx.doi.org/10.1038/s41598-020-66017-6DOI Listing

Fine-tuning of Genome-Wide Polygenic Risk Scores and Prediction of Gestational Diabetes in South Asian Women.

Sci Rep 2020 Jun 2;10(1):8941. Epub 2020 Jun 2.

Department of Medicine, McMaster University Hamilton, Ontario, Canada.

Gestational diabetes Mellitus (GDM) affects 1 in 7 births and is associated with numerous adverse health outcomes for both mother and child. GDM is suspected to share a large common genetic background with type 2 diabetes (T2D). The aim of our study was to characterize different GDM polygenic risk scores (PRSs) and test their association with GDM using data from the South Asian Birth Cohort (START). Read More

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http://dx.doi.org/10.1038/s41598-020-65360-yDOI Listing

Protocol for a mixed-method analysis of implementation of case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs.

BMJ Open 2020 Jun 1;10(6):e038241. Epub 2020 Jun 1.

Department of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Introduction: Case management (CM) in a primary care setting is a promising approach to integrating and improving healthcare services and outcomes for patients with chronic conditions and complex care needs who frequently use healthcare services. Despite evidence supporting CM and interest in implementing it in Canada, little is known about how to do this. This research aims to identify the barriers and facilitators to the implementation of a CM intervention in different primary care contexts (objective 1) and to explain the influence of the clinical context on the degree of implementation (objective 2) and on the outcomes of the intervention (objective 3). Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038241DOI Listing

Medial temporal lobe cortical changes in response to exercise interventions in people with early psychosis: A randomized controlled trial.

Schizophr Res 2020 May 30. Epub 2020 May 30.

Department of Radiology, University of British Columbia, Canada. Electronic address:

Objective: Individuals with early psychosis may have prefrontal-limbic cortical deficits, which are associated with symptom severity and cognitive impairment. This study investigated the impact of an exercise intervention on fronto-temporal cortical plasticity in female participants with early psychosis.

Methods: In a cohort of 51 female participants with early psychosis from Hong Kong, we investigated the effects of a 12-week, moderate intensity aerobic or Hatha yoga exercise trial (yoga (N = 21), aerobic (N = 18) or waitlist group (N = 12)) on cortical grey matter. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.043DOI Listing

"If you do not find the world tasty and sexy, you are out of touch with the most important things in life": Resident and family member perspectives on sexual expression in continuing care.

J Aging Stud 2020 Jun 7;53:100849. Epub 2020 May 7.

Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada. Electronic address:

Over the past three decades, there has been growing attention to sexual expression in continuing care homes. However, resident perspectives continue to be underrepresented, particularly in the Canadian context. In this article, we share findings from a qualitative, exploratory study looking at the experiences of residents and family members in Alberta, Canada. Read More

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http://dx.doi.org/10.1016/j.jaging.2020.100849DOI Listing

The burden of familial chylomicronemia syndrome in Canadian patients.

Lipids Health Dis 2020 Jun 2;19(1):120. Epub 2020 Jun 2.

Lipids, Nutrition and Cardiovascular Prevention Clinic, Montreal Clinical Research Institute, 110 Avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.

Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder characterized by persistent extreme hypertriglyceridemia as a result of lipoprotein lipase deficiency. Canada is an important region for FCS research due to the high prevalence rates. The burden of illness and quality of life of Canadian patients, however, have been inadequately addressed in the literature. Read More

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http://dx.doi.org/10.1186/s12944-020-01302-xDOI Listing

A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol.

BMC Psychiatry 2020 Jun 2;20(1):268. Epub 2020 Jun 2.

The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada.

Background: Recent evidence underscores the utility of rapid-acting antidepressant interventions, such as ketamine, in alleviating symptoms of major depressive episodes (MDE). However, to date, there have been limited head-to-head comparisons of intravenous (IV) ketamine infusions with other antidepressant treatment strategies in large randomized trials. This study protocol describes an ongoing multi-centre, prospective, randomized, crossover, non-inferiority trial comparing acute treatment of individuals meeting diagnostic criteria for a major depressive episode (MDE) with ketamine and electroconvulsive therapy (ECT) on efficacy, speed of therapeutic effects, side effects, and health care resource utilization. Read More

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http://dx.doi.org/10.1186/s12888-020-02672-3DOI Listing

Effectiveness of psychotherapeutic interventions on psychological distress in women who have experienced perinatal loss: a systematic review protocol.

Syst Rev 2020 Jun 2;9(1):125. Epub 2020 Jun 2.

Faculty of Nursing, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta, T2N 1 N4, Canada.

Background: Perinatal loss is a traumatic and complex experience that contributes to negative maternal psychological states and adverse outcomes impacting fetal development, maternal-fetal/infant bonding, marital/partner relationships, and child cognitive, emotional, and behavioral development. These outcomes present preventable disease burden and financial liability to individuals, families, and the healthcare system. Psychological interventions have the potential to improve outcomes for women and their families after perinatal loss. Read More

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http://dx.doi.org/10.1186/s13643-020-01387-6DOI Listing

A systems approach for institutional CBME adoption at Queen's University.

Med Teach 2020 Jun 2:1-6. Epub 2020 Jun 2.

Faculty of Health Sciences, Queen's University, Kingston, Canada.

The Royal College of Physicians and Surgeons of Canada (RCPSC) has begun the transition to Competency by Design (CBD), a new curricular model for residency education that 'ensure[s] competence, but teaches for excellence'. By 2022, all Canadian specialty programs are anticipated to have completed the CBD cohort process which includes workshops facilitated by a Royal College Clinician Educator. Queen's University in Ontario, Canada, was granted approval by the RCPSC to embark upon an accelerated path to competency-based medical education (CBME) for all our postgraduate specialties. Read More

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http://dx.doi.org/10.1080/0142159X.2020.1767768DOI Listing

Discrimination of four Canadian-French vowels by native Canadian-English listeners.

J Acoust Soc Am 2020 May;147(5):EL391

Department of Psychology, Brain and Mind Institute, The University of Western Ontario, London, Ontario,

Discrimination of Canadian French /y/, /u/, /ɑ/, and /e/ by native Canadian-English listeners was investigated to determine if patterns found in standard varieties of French (as explained by the Perceptual Assimilation Model) could be replicated in Canadian French. Front-rounded /y/ paired with /u/ was the focus of investigation, as well as other (control) pairs. It was found that /y/-/u/ was the most difficult to discriminate as compared to other pairs, but that listeners were sensitive to the contrast, which replicates previous findings in European French. Read More

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http://dx.doi.org/10.1121/10.0001180DOI Listing

Detection of Foot-and-Mouth Disease Virus in Swine Meat Juice.

Pathogens 2020 May 29;9(6). Epub 2020 May 29.

National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.

Foot-and-mouth disease virus (FMDV) is a highly contagious agent that impacts livestock industries worldwide, leading to significant financial loss. Its impact can be avoided or minimized if the virus is detected early. FMDV detection relies on vesicular fluid, epithelial tags, swabs, serum, and other sample types from live animals. Read More

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http://dx.doi.org/10.3390/pathogens9060424DOI Listing

Nutraceuticals and Nutrition Supplements: Challenges and Opportunities.

Nutrients 2020 May 29;12(6). Epub 2020 May 29.

Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

The term "nutraceuticals" is derived from "nutrition" and "pharmaceuticals" and is used fornutrition products that are also used as medicine [1] [... Read More

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http://dx.doi.org/10.3390/nu12061593DOI Listing

Motor Deficits in Youth with Concussion History: Issues with Task Novelty or Task Demand?

Int J Sports Med 2020 Jun 2. Epub 2020 Jun 2.

School of Kinesiology and Health Science, York University, Toronto, Canada.

The present study expands previous work on eye-hand decoupling deficits in youth with concussion history. It examines whether deficits can be linked to difficulties adapting to new task constraints or meeting ongoing task demands. Data from 59 youth with concussion history (M=11 months post-concussion) and 55 no history controls were analyzed. Read More

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http://dx.doi.org/10.1055/a-1144-3217DOI Listing

Beauty perks: Physical appearance, earnings, and fringe benefits.

Econ Hum Biol 2020 May 17;38:100889. Epub 2020 May 17.

Department of Economics, Sobey School of Business, Saint Mary's University, 923 Robie Street, Halifax, NS, B3H 3C3, Canada. Electronic address:

While the existence of a beauty premium is documented for many labour markets, there has been no study on the association of attractiveness with fringe benefits. This is a significant limitation of the extant literature, since fringe benefits are increasingly acknowledged as an integral part of the employees' compensation, and a main indicator of job quality. Using the Canadian General Social Survey of 2016, the present paper examines how a self-rated measure of attractiveness associates with both labour earnings and fringe benefits. Read More

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http://dx.doi.org/10.1016/j.ehb.2020.100889DOI Listing

Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides.

Forensic Sci Int Genet 2020 May 22;47:102309. Epub 2020 May 22.

Forensic Science Graduate Program, University of California, Davis, CA, USA; Department of Environmental Toxicology, University of California, Davis, CA, USA. Electronic address:

Recent reports highlight possible improvements in individual identification using proteomic information from human hair evidence. These reports have stimulated investigation of parameters that affect the utility of proteomic information. In addition to variables already studied relating to processing technique and anatomic origin of hair shafts, an important variable is hair ageing. Read More

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http://dx.doi.org/10.1016/j.fsigen.2020.102309DOI Listing

The role of education and other transition milestones in the progression of social inequalities in cigarette smoking between the ages of 18 and 25: Evidence from the Canadian National Population Health Survey.

Addict Behav 2020 May 19;109:106476. Epub 2020 May 19.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada; Department of Sociology, McGill University, Canada.

Young adulthood is now considered a sensitive period in the progression of health inequalities over the life-course. This age group experiences highly dynamic and socially patterned life-course events that require nuanced modelling choices compared to those commonly used in public health sciences. To illustrate this, we estimate changes in the risk of smoking according to student status, employment status, living arrangements, and relationship status at different ages across education categories. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106476DOI Listing

Combinatorial Pharmacogenomic Algorithm is Predictive of Citalopram and Escitalopram Metabolism in Patients with Major Depressive Disorder.

Psychiatry Res 2020 May 17;290:113017. Epub 2020 May 17.

University of Michigan Comprehensive Depression Center and Department of Psychiatry, and National Network of Depression Centers, Ann Arbor, MI.

Pharmacogenomic tests used to guide clinical treatment for major depressive disorder (MDD) must be thoroughly validated. One important assessment of validity is the ability to predict medication blood levels, which reflect altered metabolism. Historically, the metabolic impact of individual genes has been evaluated; however, we now know that multiple genes are often involved in medication metabolism. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113017DOI Listing

Hypomorphic CAMKK2 in EA.hy926 endothelial cells causes abnormal transferrin trafficking, iron homeostasis and glucose metabolism.

Biochim Biophys Acta Mol Cell Res 2020 May 30:118763. Epub 2020 May 30.

Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, MB, R2H 2A6, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada.

We recently reported that loss of calcium/calmodulin-dependent protein kinase kinase-2 (CAMKK2), a serine/threonine kinase activated by intracellular calcium, in mice leads to tissue-specific aberrant turnover of transferrin (TF), a receptor-mediated iron-transporter that supplies iron to tissues. Iron dyshomeostasis is associated with the pathogenesis of several diseases, making TF transport relevant to health. In this study, we used hemizygous CAMKK2 hypomorphic human endothelial cell (EA. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118763DOI Listing

Impact of migration from an illicit drug scene on hospital outcomes among people who use illicit drugs in Vancouver, Canada.

Drug Alcohol Rev 2020 Jun 2. Epub 2020 Jun 2.

British Columbia Centre on Substance Use, Vancouver, Canada.

Introduction And Aims: People who use illicit drugs (PWUD) are vulnerable to an array of negative health outcomes, and increased hospital services utilisation. PWUD are also a transient population which poses challenges to the provision of optimal health care. The objective of this study was to identify out-migration patterns from Vancouver's Downtown Eastside (DTES), a neighbourhood where services for PWUD are concentrated, and to estimate the impact of these patterns on hospitalisation events among PWUD. Read More

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http://dx.doi.org/10.1111/dar.13095DOI Listing

Honey Bee Queen Production: Canadian Costing Case Study and Profitability Analysis.

J Econ Entomol 2020 Jun 2. Epub 2020 Jun 2.

Agriculture & Agri-Food Canada, Beaverlodge Research Farm, Beaverlodge, Alberta, Canada.

The decline in managed honey bee (Hymenoptera: Apidae) colony health worldwide has had a significant impact on the beekeeping industry. To mitigate colony losses, beekeepers in Canada and around the world introduce queens into replacement colonies; however, Canada's short queen rearing season has historically limited the production of early season queens. As a result, Canadian beekeepers rely on the importation of foreign bees, particularly queens from warmer climates. Read More

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http://dx.doi.org/10.1093/jee/toaa102DOI Listing

Role of Policy in Best-Practice Dissemination: Informal Professional Advice Networks in Canadian Long-Term Care.

Can J Aging 2020 Jun 2:1-11. Epub 2020 Jun 2.

Faculty of Nursing, University of Alberta.

This article examines provincial policy influence on long-term care (LTC) professionals' advice-seeking networks in Canada's Maritime provinces. The effects of facility ownership, geography, and region-specific political landscapes on LTC best-practice dissemination are examined. We used sociometric statistics and network sociograms, calculated from surveys with 169 senior leaders in LTC facilities, to identify advice-seeking network structures and to select 11 follow-up interview participants. Read More

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http://dx.doi.org/10.1017/S0714980820000057DOI Listing

Confinement of Dyes inside Boron Nitride Nanotubes: Photostable and Shifted Fluorescence down to the Near Infrared.

Adv Mater 2020 Jun 2:e2001429. Epub 2020 Jun 2.

Laboratoire d'Etude des Microstructures, ONERA-CNRS, UMR104, Université Paris-Saclay, BP 72, Châtillon, 92322, France.

Fluorescence is ubiquitous in life science and used in many fields of research ranging from ecology to medicine. Among the most common fluorogenic compounds, dyes are being exploited in bioimaging for their outstanding optical properties from UV down to the near IR (NIR). However, dye molecules are often toxic to living organisms and photodegradable, which limits the time window for in vivo experiments. Read More

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http://dx.doi.org/10.1002/adma.202001429DOI Listing

Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.

Theranostics 2020 15;10(14):6337-6360. Epub 2020 May 15.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.

Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is a potential target for neurodegenerative diseases, such as Alzheimer's disease (AD). Increasing evidence shows that impairment of adult neurogenesis by perturbed lipid metabolism predisposes patients to AD. However, it remains unknown what causes aberrant expression of Mgll in AD and how Mgll-regulated lipid metabolism impacts adult neurogenesis, thus predisposing to AD during aging. Read More

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http://dx.doi.org/10.7150/thno.44962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255032PMC

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor.

Nat Commun 2020 Jun 1;11(1):2707. Epub 2020 Jun 1.

Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000, Strasbourg, France.

Chronic HBV infection is a major cause of liver disease and cancer worldwide. Approaches for cure are lacking, and the knowledge of virus-host interactions is still limited. Here, we perform a genome-wide gain-of-function screen using a poorly permissive hepatoma cell line to uncover host factors enhancing HBV infection. Read More

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http://dx.doi.org/10.1038/s41467-020-16517-wDOI Listing

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs.

Nat Commun 2020 Jun 1;11(1):2697. Epub 2020 Jun 1.

Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.

CRISPR-Cas9 nucleases are powerful genome engineering tools, but unwanted cleavage at off-target and previously edited sites remains a major concern. Numerous strategies to reduce unwanted cleavage have been devised, but all are imperfect. Here, we report that off-target sites can be shielded from the active Cas9•single guide RNA (sgRNA) complex through the co-administration of dead-RNAs (dRNAs), truncated guide RNAs that direct Cas9 binding but not cleavage. Read More

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http://dx.doi.org/10.1038/s41467-020-16542-9DOI Listing

Awake Craniotomy Under 3-Tesla Intraoperative Magnetic Resonance Imaging: A Retrospective Descriptive Report and Canadian Institutional Experience.

J Neurosurg Anesthesiol 2020 May 29. Epub 2020 May 29.

Department of Surgery, Section-Neurosurgery, Clincian Investigator Program, Max Rady College of Medicine, Rady Faculty of Health Sciences.

Background: The role of high-field 3-Tesla intraoperative magnetic resonance imaging (I-MRI) during awake craniotomy (AC) has not been extensively studied. We report the feasibility and safety of AC during 3-Tesla I-MRI.

Methods: This retrospective descriptive report compared 3 groups: AC with minimal sedation and I-MRI; I-MRI-guided craniotomy under general anesthesia (GA), and; AC without I-MRI. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000699DOI Listing

Population-based Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients: A Real-world Evidence Study.

Am J Clin Oncol 2020 May 29. Epub 2020 May 29.

Alberta Health Services (AHS), Edmonton, AB.

Background: Most patients with stage III non-small cell lung cancer (NSCLC) develop metastases and succumb to their cancer. Approaches to the treatment of stage III disease can be highly variable. Understanding current treatment patterns can inform the optimal integration of emerging therapies. Read More

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http://dx.doi.org/10.1097/COC.0000000000000716DOI Listing

Granularity of alleles by DNA sequencing in CanCOLD.

Eur Respir J 2020 Jun 1. Epub 2020 Jun 1.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Québec, Canada

DNA sequencing of the gene to detect alpha-1 antitrypsin deficiency (AATD) may provide a better appreciation of the individual and cumulative impact of genetic variants on alpha-1 antitrypsin (AAT) serum levels and COPD phenotypes.AAT serum level and DNA sequencing of the coding regions of were performed in 1359 participants of the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Clinical assessment for COPD included questionnaires, pulmonary function testing and computed tomography (CT) imaging. Read More

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http://dx.doi.org/10.1183/13993003.00958-2020DOI Listing

Colon and rectal cancer survival in seven high-income countries 2010-2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project).

Gut 2020 Jun 1. Epub 2020 Jun 1.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

Objectives: As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income countries by age and stage at diagnosis.

Methods: Data from 386 870 patients diagnosed during 2010-2014 from 19 cancer registries in seven countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK) were analysed. 1-year and 5-year net survival from colon and rectal cancer were estimated by stage at diagnosis, age and country, RESULTS: (One1-year) and 5-year net survival varied between (77. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320625DOI Listing

Canadian Rheumatology Association Meeting, Fairmont Empress, Victoria, British Columbia, Canada, February 26-29, 2020.

Authors:

J Rheumatol 2020 Jun 1. Epub 2020 Jun 1.

The 74th Annual Meeting of The Canadian Rheumatology Association was held at the Fairmont Empress, Victoria, British Columbia, Canada, February 26-29, 2020. The program consisted of presentations covering original research, symposia, awards, and lectures. Read More

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http://dx.doi.org/10.3899/jrheum.200419DOI Listing