120,522 results match your criteria Canadian Modern Language Review-revue Canadienne Des Langues Vivantes[Journal]


Re-imagining miyo-wicehtowin: Human-nature relations, land-making, and wellness among Indigenous youth in a Canadian urban context.

Soc Sci Med 2019 Apr 13;230:122-130. Epub 2019 Apr 13.

Wiyasiwewin Mikiwahp Native Law Centre, College of Law, University of Saskatchewan, Canada.

Relationships to land and nature have long been recognized globally as a central Indigenous determinant of health. As more Indigenous peoples migrate to larger urban centers, it is crucial to better understand how these relationships are maintained or function within urban spaces. This article outlines the results of a year-long collaborative study that qualitatively explored Indigenous young peoples' connections between "land," nature, and wellness in an urban Canadian context. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.04.012DOI Listing

Knowledge and Opinions Among Canadian Academic Physicians Regarding Genetic Screening to Prevent Severe Cutaneous Adverse Drug Reactions.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; The Ruth and Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Israel; Department of Dermatology, Emek Medical Centre, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.04.040DOI Listing

Development and Pilot Testing of an Assessment Tool for Performance of Invasive Mediastinal Staging.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

Thoracic Surgery, University of Alberta.

Background: To develop and evaluate a surgical trainee competency assessment instrument for invasive mediastinal staging, including cervical mediastinoscopy and endobronchial ultrasound (EBUS), a comprehensive instrument was developed utilizing expert review and simulated and clinical pilot-testing: Thoracic Competency Assessment Tool-Invasive Staging (TCAT-IS).

Methods: Validity and reliability evidence was collected and item analysis was performed. Initially, a 27-item instrument was developed, which underwent expert review with members of the Canadian Association of Thoracic Surgeons (n=86) in 2014-2015 (response rate 57%). Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.050DOI Listing

Law and Disorder: Special Stacking Units-Building the Intergrowth CeCoGe.

Inorg Chem 2019 Apr 22. Epub 2019 Apr 22.

Center for Nanophysics and Advanced Materials, Department of Physics , University of Maryland , College Park , Maryland 20742 , United States.

A new structure type of composition CeCoGe was grown out of a molten Sn flux. CeCoGe crystallizes in the orthorhombic space group Cmcm, with highly anisotropic lattice parameters of a = 4.3293(5) Å, b = 55. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00350DOI Listing

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR).

Histopathology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN, USA.

Aims: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, the European Society of Pathology, the American Society of Clinical Pathology and the Faculty of Pathology, Royal College of Physicians of Ireland. Its goal is to produce standardized, internationally agreed upon, evidence-based datasets for cancer pathology reporting throughout the world.

Methods And Results: This paper describes the development of a cancer dataset by the multidisciplinary ICCR expert panel for the reporting of carcinoma of the urethra in urethrectomy specimens. Read More

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http://dx.doi.org/10.1111/his.13877DOI Listing

Counteracting Health Misinformation: A Role for Medical Journals?

JAMA 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.5168DOI Listing
April 2019
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PrEP-RN: Clinical Considerations and Protocols for Nurse-Led PrEP.

J Assoc Nurses AIDS Care 2019 Apr 9. Epub 2019 Apr 9.

HIV pre-exposure prophylaxis (PrEP) is an increasingly important part of the HIV prevention armamentarium. Issues with PrEP, however, include access. We propose that one way to surmount this issue would be to have nurses provide PrEP. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000075DOI Listing

Professionals' Knowledge, Attitudes, and Practices Related to Pressure Injuries in Canada.

Adv Skin Wound Care 2019 May;32(5):228-233

In Ontario, Canada, Kimberly LeBlanc PhD, RN, WOCC (C), IIWCC, is Chair, Wound Ostomy Continence Institute, Ottawa; Kevin Woo, PhD, RN, NSWOC, FAPWCA, is Associate Professor, Faculty of Health Sciences, Queen's University, Kingston; Katie Bassett, BA, is Communications Specialist, Wounds Canada, North York; Mariam Botros, DPM, is Executive Director, Wounds Canada, and Director, Diabetic Foot Canada, North York.

Background: Pressure injuries (PIs) represent a significant burden on the healthcare system and have a negative impact on the quality of life of those affected by these wounds. Despite best practice guidelines and other protocols to help healthcare facilities prevent PIs, the prevalence of PIs in Canada across all healthcare settings is concerning.

Objective: To describe the pattern of PI prevention and identify national priorities and opportunities to address PIs. Read More

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http://dx.doi.org/10.1097/01.ASW.0000554444.52120.f6DOI Listing

Fatal West Nile Virus Infection in a Virginia Opossum () with Pulmonary Lepidic-Predominant Adenocarcinoma.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

1 Centre québécois sur la santé des animaux sauvages/Canadian Wildlife Health Cooperative, Faculté de médecine vétérinaire, Université de Montréal, 3200 rue Sicotte, St. Hyacinthe, Quebec J2S 2M2, Canada.

A fatal case of West Nile virus (WNV) infection was diagnosed based on histopathologic findings and the presence of WNV RNA by reverse transcription PCR in the affected organs in a Virginia opossum () in Quebec, Canada in 2017. Disease caused by WNV has not been described in a marsupial species. Read More

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Everyday associations between older adults' physical activity, negative affect, and cortisol.

Health Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, The University of British Columbia.

Objective: Experimental research has demonstrated that individuals with higher physical activity levels show reduced cortisol responses to psychosocial stress. The present study takes this research out of the lab and it extends these findings by investigating whether older adults' physical activity also moderates everyday-life within-person associations between momentary negative affect and concurrent salivary cortisol.

Methods: A sample of 162 older adults aged 60 to 87 years (M age = 71 years; 50% women; 57% Caucasian) completed affect assessments and provided concurrent salivary cortisol samples 4 times per day over 7 consecutive days. Read More

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http://dx.doi.org/10.1037/hea0000743DOI Listing

Prediabetes: An emerging public health concern in adolescents.

Endocrinol Diabetes Metab 2019 Apr 1;2(2):e00060. Epub 2019 Mar 1.

Faculty of Medicine, College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada.

Objectives: To identify the presence of risk factors for type 2 diabetes (ethnicity, body mass index, blood glucose tolerance and blood pressure) and to determine the prevalence of prediabetes and type 2 diabetes in Canadian adolescents attending two multicultural urban high schools.

Methods: A total of 266 multicultural urban high school students who live in a mid-sized Western Canadian city, aged 14-21, were screened for risk factors of prediabetes and type 2 diabetes in March-April 2018. Data with respect to demographics, family history of diabetes, anthropometrics, blood pressure and haemoglobin A1c (HbA1c) were collected. Read More

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http://dx.doi.org/10.1002/edm2.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458462PMC

Evaluation of Different Stabilizers and Inactivating Compounds for the Enhancement of Vero Cell Rabies Vaccine Stability and Immunogenicity: Study.

Biomed Res Int 2019 17;2019:4518163. Epub 2019 Mar 17.

Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia.

Inactivation of rabies virus is essential for rabies vaccine preparation where the inactivating compound that is currently recommended for rabies vaccine preparation is -propiolactone (-PL). This compound is considered better than phenol and formalin but it is expensive and potentially carcinogenic. Data revealed that Ascorbic acid (AA) with cupric ions could yield complete and irreversible inactivation of rabies virus without adversely affecting its antigenicity. Read More

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http://dx.doi.org/10.1155/2019/4518163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441502PMC

Youth consumption of alcohol mixed with energy drinks in Canada: Assessing the role of energy drinks.

Prev Med Rep 2019 Jun 5;14:100865. Epub 2019 Apr 5.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada.

Consuming alcohol mixed with energy drinks (AmED) is a risk behaviour among youth, and previous research has reported a positive association between binge drinking and AmED consumption. However, limited research has examined how regular consumption of energy drinks is associated with AmED consumption among youth. The purpose of this report is to examine the role of energy drink use on AmED consumption in a Canadian youth population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193005
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http://dx.doi.org/10.1016/j.pmedr.2019.100865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458478PMC

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

Raccoon rabies outbreak in Hamilton, Ontario: A progress report.

Can Commun Dis Rep 2018 May 3;44(5):116-121. Epub 2018 May 3.

Region of Peel, Mississauga, ON.

Background: Raccoon rabies is caused by a variant of the rabies virus found in raccoons but transmissible to other mammalian species, including humans. The disease of rabies caused by raccoon variant rabies virus is indistinguishable from rabies caused by other rabies virus variants.

Objective: This paper describes the raccoon rabies outbreak in Ontario (identified in December 2015) and the control measures undertaken to curb the spread of the epizootic using the One Health approach. Read More

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Canadian Pandemic Influenza Preparedness: Communications strategy.

Authors:
B Henry

Can Commun Dis Rep 2018 May 3;44(5):106-109. Epub 2018 May 3.

CPIP Task Group Chair.

When faced with uncertainty and unpredictability, early and transparent communication during a pandemic is critical to build trust and to ensure the credibility of public health advice. The responsibility for communicating with Canadians during a pandemic is shared by federal, provincial, territorial and local governments. A common plan is needed to ensure consistent, coordinated and appropriate communication. Read More

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An overview of the National Microbiology Laboratory emergency management program.

Authors:
D Marcino K Gordon

Can Commun Dis Rep 2018 May 3;44(5):102-105. Epub 2018 May 3.

National Microbiology Laboratory, Public Health Agency of Canada, WinnipegMB.

The National Microbiology Laboratory (NML) emergency management program was developed after the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak to provide a framework for the responses to public health events. The program comprises three components (Site response, Continuity and Site support) that have adopted the Incident Command System (ICS) as their management structure and follows the four phases of emergency management. All program components have extensive competency-based training for staff and exercise plans. Read More

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Fifteen years post-SARS: Key milestones in Canada's public health emergency response.

Authors:
T Tam

Can Commun Dis Rep 2018 May 3;44(5):98-101. Epub 2018 May 3.

Public Health Agency of Canada, Ottawa, ON.

This year marks the 15th anniversary of Severe Acute Respiratory Syndrome (SARS) in Canada and the 100th anniversary of the 1918 Spanish influenza pandemic. These, and other recent public health events, provide an opportunity for us to review and reflect on the evolution of Canada's public health emergency response over the past 15 years-from SARS, to the 2009 H1N1 pandemic influenza, to Ebola virus and Zika virus disease. Key lessons have been learned and milestones achieved that have shaped and sharpened our response approach and structures. Read More

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Addressing tuberculosis among Inuit in Canada.

Can Commun Dis Rep 2018 Mar 1;44(3-4):82-85. Epub 2018 Mar 1.

Ministry of Health, Government of Nunavut, Iqaluit, NU.

The average annual rate of tuberculosis (TB) among Inuit in Canada is now more than 290 times higher than Canadian born non-Indigenous people. How did this happen? Using the Territory of Nunavut as a case example, the roots of this situation can largely be traced back to social determinants of health and challenges in access to health care. Half (52%) of all Nunavut residents live in social housing, often under overcrowded conditions. Read More

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Tuberculosis in Canada, 2016.

Can Commun Dis Rep 2018 Mar 1;44(3-4):75-81. Epub 2018 Mar 1.

Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Background: Tuberculosis (TB) is a major global health problem that affected an estimated 10.4 million people worldwide in 2016. The Public Health Agency of Canada (PHAC) monitors active TB disease through a national surveillance system, which is a collaborative effort withthe provinces and territories. Read More

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Outcomes During Early Implementation of Mifepristone-Buccal Misoprostol Abortions up to 63 Days of Gestation in a Canadian Clinical Setting.

J Obstet Gynaecol Can 2019 May 26;41(5):647-652. Epub 2018 Oct 26.

Department of Family and Community Medicine, University of Toronto, Toronto, ON; Women's College Hospital Family Practice Health Centre, Toronto, ON.

Objective: In January 2017, mifepristone became available in Canada. The goal of this study was to determine the effectiveness and safety of mifepristone-misoprostol abortion during its early implementation in a Canadian setting.

Methods: This retrospective chart review included the first 477 patients who had a mifepristone-misoprostol abortion from March 13 to October 31, 2017, in an urban sexual health clinic. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.05.030DOI Listing

FIGO Stage Is the Strongest Prognostic Factor in Adenocarcinoma of the Uterine Cervix.

J Obstet Gynaecol Can 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, AB; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB; Calgary Laboratory Services, Calgary, AB.

Objective: This study aimed to identify clinical and pathological determinants of invasive adenocarcinoma of the uterine cervix (AC) in a large, single-centre series serving a population of 1.5 million.

Methods: Data on clinical (n = 27) and pathological (n = 23) variables for 166 women with a diagnosis of AC treated between 2000 and 2013 were extracted from their charts and pathology reports. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.01.026DOI Listing

Use of personal mobile devices to record patient data by Canadian emergency physicians and residents.

CJEM 2019 Apr 22:1-5. Epub 2019 Apr 22.

†Emergency Department,Vancouver General Hospital,Vancouver Coastal Health,Vancouver,BC.

Objective: Use of personal mobile devices to record patient data appears to be increasing, but remains poorly studied. We sought to determine the extent and reasons that Canadian emergency physicians (EPs) and emergency medicine residents use personal mobile devices to record patient data in the emergency department (ED).

Methods: A national survey was distributed to Canadian EPs and residents between 27/02/17 and 23/03/17. Read More

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http://dx.doi.org/10.1017/cem.2019.29DOI Listing

Buprenorphine/naloxone induction in a Canadian emergency department with rapid access to community-based addictions providers.

CJEM 2019 Apr 22:1-7. Epub 2019 Apr 22.

*Department of Family and Community Medicine,University of Toronto,Toronto,ON.

Objectives: Opioid-related emergency department (ED) visits have increased significantly in recent years. Our objective was to evaluate an ED-initiated buprenorphine/naloxone program, which provided rapid access to an outpatient community-based addictions clinic, for patients in opioid withdrawal.

Methods: A retrospective chart review was completed within a health system encompassing four community EDs in Ontario, Canada. Read More

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http://dx.doi.org/10.1017/cem.2019.24DOI Listing

Tracheobronchopathia osteochondroplastica: a rare tracheal lesion in a free-ranging grizzly bear.

J Vet Diagn Invest 2019 Apr 22:1040638719844553. Epub 2019 Apr 22.

Department of Ecosystem and Public Health, Canadian Wildlife Health Cooperative (Alberta), Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.

A mature male grizzly bear ( Ursus arctos) that died of blunt-force trauma had numerous hard 1-3-mm nodules protruding from tracheal rings into the lumen of the distal trachea. Histologically, these were round aggregates of mature cartilage within the submucosa. Such lesions are consistent with tracheobronchopathia osteochondroplastica, a rare tracheal disease in humans and animals. Read More

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http://dx.doi.org/10.1177/1040638719844553DOI Listing

Does the site of coronary endarterectomy have an impact on the clinical outcomes and graft patency?

Interact Cardiovasc Thorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: To explore whether coronary endarterectomy (CE) sites have obvious impacts on the clinical outcomes and graft patency in off-pump coronary artery bypass (OPCAB).

Methods: The patients who underwent OPCAB with CE in our unit between January 2009 and December 2016 were included. The patients and the grafts were grouped according to the CE sites. Read More

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http://dx.doi.org/10.1093/icvts/ivz099DOI Listing

The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants†.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objectives: Neurodevelopmental disability is the most common complication among congenital heart surgery survivors. The Bayley scales are standardized instruments to assess neurodevelopment. The most recent edition (Bayley Scales of Infant and Toddler Development 3rd Edition, Bayley-III) yields better-than-expected scores in typically developing and high-risk infants than the second edition (Bayley Scales of Infant Development 2nd Edition, BSID-II). Read More

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http://dx.doi.org/10.1093/ejcts/ezz123DOI Listing

The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Nutrition Research Division.

Background: Maternal nutrition and genetics are determinants of breast-milk nutrient composition and, as such, are determinants of the nutritional exposure of breastfed infants.

Objectives: The aim of this study was to determine whether common maternal single nucleotide polymorphisms (SNPs) in folate-dependent enzymes are associated with breast-milk folate content in a cohort of mothers enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Methods: The MIREC study is a Canadian prospective pregnancy cohort study that recruited 2001 participants between 2008 and 2011. Read More

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http://dx.doi.org/10.1093/ajcn/nqz056DOI Listing

A theory-based, task-oriented, outdoor walking programme for older adults with difficulty walking outdoors: protocol for the Getting Older Adults Outdoors (GO-OUT) randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e029393. Epub 2019 Apr 20.

College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Introduction: A theory-based, task-oriented, community walking programme can increase outdoor walking activity among older adults to optimise functional independence, social participation and well-being. The study objective is to determine if there is a difference in the change in outdoor walking activity from baseline to 10 weeks, 5.5 months and 12 months after receiving a 1-day interactive workshop and outdoor walking programme (Getting Older Adults Outdoors (GO-OUT)) compared with the workshop and weekly reminders (WR) in older adults with difficulty walking outdoors. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2019-02939
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http://dx.doi.org/10.1136/bmjopen-2019-029393DOI Listing
April 2019
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Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ Open 2019 Apr 20;9(4):e028444. Epub 2019 Apr 20.

The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. HIV persists in long-lived CD4+ T cells, which form the major viral reservoir. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028444DOI Listing

Identifying systems delays in assessment, diagnosis, and operative management for testicular torsion in a single-payer health-care system.

J Pediatr Urol 2019 Mar 29. Epub 2019 Mar 29.

Department of Surgery, Division of Urology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada; Department of Surgery, Division of Paediatric Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada; Department of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. Electronic address:

Introduction: Testicular torsion (TT) is a common pediatric urologic emergency. Management of TT is time sensitive and often confirmed on scrotal Doppler ultrasound (DUS). Acquiring DUS, however, can result in delays in the management of TT, affecting testicular salvage rates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131193007
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http://dx.doi.org/10.1016/j.jpurol.2019.03.017DOI Listing
March 2019
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A comparative study of viscoelastic hemostatic assays and conventional coagulation tests in trauma patients receiving fibrinogen concentrate.

Clin Chim Acta 2019 Apr 17. Epub 2019 Apr 17.

Royal Canadian Medical Services, Ottawa, ON, Canada; McGill University, Montreal, QC, Canada.

Background: Both thrombelastography (TEG) and rotational thromboelastometry (ROTEM) have been investigated for diagnosis of coagulopathy and guidance of resuscitation in trauma and surgery. Given similarities between the two systems, it is important to determine whether one is superior to the other and how comparable they are to conventional coagulation tests (CCTs). Therefore, we conducted a comparative study of functional fibrinogen and coagulation assays using TEG and ROTEM and CCTs to determine their capability to monitor coagulation profiles, diagnose coagulopathy and predict blood transfusion requirements in trauma patients. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.066DOI Listing

Factors Affecting Performance on an Army Urban Operation Casualty Evacuation for Male and Female Soldiers.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Human Performance Research and Development, Canadian Forces Morale and Welfare Services, Department of National Defence, 4210 Labelle Street, On.K1J 1J8, Canada.

Introduction: This study was conducted to determine what physical and physiological characteristics contribute to the performance of an urban operation casualty evacuation (UO) and its predictive test, FORCE combat (FC) and describe the metabolic demand of the UO in female soldiers.

Methods: Seventeen military members (9 M and 8 F) completed a loaded walking maximal aerobic test, the UO and FC. Heart rate reserve (HRR) and completion time were used as efficiency/performance measures. Read More

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http://dx.doi.org/10.1093/milmed/usz075DOI Listing

Lifestyle Behavior and Mental Health in Early Adolescence.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

Population Health Intervention Research Unit, School of Public Health, Edmonton, University of Alberta, Edmonton, Canada;

Background And Objectives: Mental illnesses affect >15% of Canadian adolescents. New preventive strategies are critically needed. We examined the associations of meeting established recommendations for diet, physical activity, sleep, and sedentary behavior in childhood with mental illness in adolescence. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-3307DOI Listing
April 2019
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The Quality of Information on Combined Oral Contraceptives Available on the Internet.

J Obstet Gynaecol Can 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB. Electronic address:

Objective: Combined oral contraceptives (COC) are a popular choice among women. The Internet is an accessible and popular source of information on contraception. The objective of this study was to evaluate the quality of online information on COC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163193008
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http://dx.doi.org/10.1016/j.jogc.2019.01.024DOI Listing
April 2019
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Impact of Episiotomy During Operative Vaginal Delivery on Obstetrical Anal Sphincter Injuries.

J Obstet Gynaecol Can 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, University of Alberta, Lois Hole Hospital for Women, Edmonton, AB. Electronic address:

Objective: The purpose of this study was to describe associations between episiotomy at the time of forceps or vacuum-assisted delivery and obstetrical anal sphincter injuries (OASIS).

Methods: This population-based retrospective cohort study used delivery information from a provincial perinatal clinical database. Full-term, singleton, in-hospital, operative vaginal deliveries of vertex-presenting infants from April 1, 2006 to March 31, 2016 were identified. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.02.016DOI Listing

Perceived Barriers to the Development of Technical Skill Proficiency in Surgical Clerkship.

J Surg Educ 2019 Apr 16. Epub 2019 Apr 16.

Division of General Surgery, London Health Sciences Center, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Objective: Medical students are expected to achieve proficiency in a prescribed set of technical skills during surgical clerkship. However, available literature indicates students routinely report a lack of confidence and proficiency in these skills. Our study aims to identify barriers to technical skill development encountered by medical students during surgical clerkship with the goal of developing interventions to address these barriers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19317204183076
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http://dx.doi.org/10.1016/j.jsurg.2019.03.020DOI Listing
April 2019
1 Read

Sexual health-related training of Canadian midwives and its association with practice outcome.

Women Birth 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychology, Queen's University, Kingston, ON, Canada.

Background: Although promoting sexual health should be an integral part of midwifery practice, little is known about midwives' preparation to address their clients' sexual health concerns.

Aims: To assess the formal and self-directed training on sexual health topics relevant to midwifery practice of Canadian midwives as well as the association between training and various practice outcomes.

Methods: Forty midwives registered in the Province of Ontario, Canada completed an online survey assessing their formal and self-directed sexual health training, knowledge, comfort, and practice related to 10 sexual health issues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18715192193001
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http://dx.doi.org/10.1016/j.wombi.2019.03.017DOI Listing
April 2019
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Bone mineral density in patients with longstanding type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.

J Diabetes Complications 2018 Dec 22. Epub 2018 Dec 22.

Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

Aim: It is currently unclear if longstanding type 1 diabetes (T1D) affects bone mineral density (BMD).

Methods: BMD measured by dual-energy X-ray absorptiometry and history of fragility fracture was determined in 75 T1D participants with ≥50 years of diabetes duration and 75 age- and sex-matched non-diabetic controls. BMD T-scores were determined for the lumbar spine (LS), total hip (TH) and femoral neck (FN). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183108
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.009DOI Listing
December 2018
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Change in young people's spine pain following chiropractic care at a publicly funded healthcare facility in Canada.

Complement Ther Clin Pract 2019 May 16;35:301-307. Epub 2019 Mar 16.

Manitoba Chiropractors Association, Canadian Chiropractic Association, Canada.

Background: The presence of spinal pain in young people has been established as a risk factor for spinal pain later in life. Recent clinical practice guidelines recommend spinal manipulation (SM), soft tissue therapy, acupuncture, and other modalities that are common treatments provided by chiropractors, as interventions for spine pain. Less is known specifically on the response to chiropractic management in young people with spinal pain. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.03.013DOI Listing
May 2019
1 Read

Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt/β-catenin signaling pathway.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology & Toxicology, Cairo University, Cairo, Egypt. Electronic address:

Exposure to repetitive brain trauma has gained attention for its similarity to sport-related trauma. The traumatic brain injury (TBI) is strongly associated with neurodegenerative pathology that affects cognition, memory and behavior. The current study developed a novel mild repetitive traumatic brain injury (mRTBI) model to highlight some of the possible molecular pathological mechanisms compared to those of single trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193018
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http://dx.doi.org/10.1016/j.brainres.2019.04.003DOI Listing
April 2019
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Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/JP277775
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http://dx.doi.org/10.1113/JP277775DOI Listing
April 2019
2 Reads

Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
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Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e22-e38. Epub 2019 Jan 22.

College of Pharmacy, University of Manitoba.

Purpose:  1) To evaluate trends for benzodiazepines (BZD) and Z-Drugs over 15-years in a general Canadian adult population measured by: a) consumption b) pharmacologic exposure c) dose intensity and d) prevalence of use. 2) To demonstrate the utility of Diazepam Milligram Equivalence (DME) based measurements when used in conjunction with traditional standard measurements of drug utilization such as the Defined Daily Dose (DDD) system.

Methods: Administrative data covering all prescriptions from April 2001-March 2016 for BZD and Z-Drugs for patients ≥18 years was used. Read More

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http://www.jptcp.com/index.php/jptcp/article/view/52
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http://dx.doi.org/10.22374/1710-6222.26.1.3DOI Listing
January 2019
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Response to Letter to the Editor.

Authors:
Nigel S B Rawson

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e20-e21. Epub 2019 Jan 22.

Eastlake Research Group, Oakville, Ontario; Canadian Health Policy Institute, Toronto; Ontario; Fraser Institute, Vancouver, British Columbi.

Author's response to comments from Dr Lexchin's Letter to the Editor regarding our article. Read More

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http://jptcp.com/index.php/jptcp/article/view/394
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http://dx.doi.org/10.22374/1710-6222.26.1.2DOI Listing
January 2019
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What is your diagnosis? A shoulder mass in a great horned owl.

Vet Clin Pathol 2019 Apr 19. Epub 2019 Apr 19.

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vcp.12738
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http://dx.doi.org/10.1111/vcp.12738DOI Listing
April 2019
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Reducing ethnic disparity in access to high-quality HLA-matched cord blood units for transplantation: analysis of the Canadian Blood Services' Cord Blood Bank inventory.

Transfusion 2019 Apr 19. Epub 2019 Apr 19.

Canadian Blood Services' Cord Blood Bank, Ottawa, Ontario.

Background: Launched in 2013, Canadian Blood Services' Cord Blood Bank (CBS' CBB) has built a high-quality, ethnically diverse cord blood repository that aims to reduce ethnic disparity in accessing suitable units for transplantation.

Methods And Results: As of December 2016, 2000 units have been banked. The self-reported maternal ethnicity was 58% non-Caucasian. Read More

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http://dx.doi.org/10.1111/trf.15313DOI Listing

Training Pediatric Residents in Literacy Promotion: Residency Directors' Perspectives.

Teach Learn Med 2019 Apr 19:1-8. Epub 2019 Apr 19.

a The Department of Pediatrics , Rutgers Robert Wood Johnson Medical School , New Brunswick , New Jersey , USA.

Phenomenon: The American Academy of Pediatrics and Canadian Pediatric Society recommend that pediatricians incorporate literacy promotion during well child care, but literacy promotion education during pediatric training remains understudied. We sought to understand how literacy promotion training is currently implemented in pediatric residency programs from the perspective of program directors. Approach: We conducted semistructured interviews with all 9 residency program directors in 1 state. Read More

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http://dx.doi.org/10.1080/10401334.2019.1598866DOI Listing
April 2019
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Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Cancer Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.1996
Publisher Site
http://dx.doi.org/10.1002/cam4.1996DOI Listing
April 2019
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Gene expression analysis of follicular cells revealed inflammation as a potential IVF failure cause.

J Assist Reprod Genet 2019 Apr 18. Epub 2019 Apr 18.

Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), Université Laval, 2440 Boulevard Hochelaga, Québec, QC, G1V 0A6, Canada.

Purpose: Hormonal stimulation prior to IVF influences the ovarian environment and therefore impacts oocytes and subsequent embryo quality. Not every patient has the same response to the same treatment and many fail for unknown reasons. Knowing why a cycle has failed and how the follicles were affected would allow clinicians to adapt the treatment accordingly and improve success rate. Read More

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http://dx.doi.org/10.1007/s10815-019-01447-4DOI Listing