127,596 results match your criteria Canadian Metallurgical Quarterly[Journal]


Effects of the COVID-19 pandemic on supply and use of blood for transfusion.

Lancet Haematol 2020 Jul 3. Epub 2020 Jul 3.

Manchester University NHS Foundation Trust, Manchester, UK.

The COVID-19 pandemic has major implications for blood transfusion. There are uncertain patterns of demand, and transfusion institutions need to plan for reductions in donations and loss of crucial staff because of sickness and public health restrictions. We systematically searched for relevant studies addressing the transfusion chain-from donor, through collection and processing, to patients-to provide a synthesis of the published literature and guidance during times of potential or actual shortage. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30186-1DOI Listing

Knock-out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post-myocardial infarction.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Toronto General Research Institute, University Health Network, Toronto, ON, Canada.

Prevention of infarct scar thinning and dilatation and stimulation of scar contracture can prevent progressive heart failure. Since microRNA 145 (miR-145) plays an important role in cardiac fibroblast response to wound healing and cardiac repair after an myocardial infarction (MI), using a miR-145 knock-out (KO) mouse model, we evaluated contribution of down-regulation of miR-145 to cardiac fibroblast and myofibroblast function during adverse cardiac remodelling. Cardiac function decreased more and the infarct size was larger in miR-145 KO than that in WT mice after MI and this phenomenon was accompanied by a decrease in cardiac fibroblast-to-myofibroblast differentiation. Read More

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http://dx.doi.org/10.1111/jcmm.15597DOI Listing

Is mammography screening beneficial: An individual-based stochastic model for breast cancer incidence and mortality.

PLoS Comput Biol 2020 Jul 6;16(7):e1008036. Epub 2020 Jul 6.

Department of Mathematics, University of Utah, Salt Lake City, Utah, United States of America.

The benefits of mammography screening have been controversial, with conflicting findings from various studies. We hypothesize that unmeasured heterogeneity in tumor aggressiveness underlies these conflicting results. Based on published data from the Canadian National Breast Screening Study (CNBSS), we develop and parameterize an individual-based mechanistic model for breast cancer incidence and mortality that tracks five stages of breast cancer progression and incorporates the effects of age on breast cancer incidence and all-cause mortality. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1008036DOI Listing

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.

PLoS Med 2020 Jul 6;17(7):e1003172. Epub 2020 Jul 6.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The "trimorbidity" of substance use disorder and mental and physical illness is associated with living in precarious housing or homelessness. The extent to which substance use increases risk of psychosis and both contribute to mortality needs investigation in longitudinal studies.

Methods And Findings: A community-based sample of 437 adults (330 men, mean [SD] age 40. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003172DOI Listing

Development of Best Practices of Peer Review for Lung Radiation Therapy.

JCO Oncol Pract 2020 Jul 6:OP2000066. Epub 2020 Jul 6.

Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario, Canada.

Purpose: Peer review (PR) is an important component in ensuring high-quality lung radiotherapy (RT) plans. However, there are inconsistencies in the extent, timing, and minimum requirements for PR. We sought to develop guidelines of best practices for PR in curative lung RT through an expert consensus process. Read More

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http://dx.doi.org/10.1200/OP.20.00066DOI Listing

Do Faba Bean Genotypes Carrying Different Zero-Tannin Genes ( and ) Differ in Phenolic Profiles?

J Agric Food Chem 2020 Jul 6. Epub 2020 Jul 6.

Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A8, Canada.

Faba bean is a cool season grain legume that produces seeds with a high protein content. Seed coat tannins limit its use in food and feed. A low-tannin phenotype is controlled by either of two unlinked recessive genes and . Read More

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http://dx.doi.org/10.1021/acs.jafc.9b07866DOI Listing

Anatomical and histological study of the alar fascia.

Clin Anat 2020 Jul 6. Epub 2020 Jul 6.

Department of Anatomical Sciences, St. George's University, Grenada, West Indies.

Introduction: The alar fascia remains one of the most variably described fascial structure in the human body. Much disagreement persists in the literature and mainstream anatomical texts about its anatomy, function, and clinical significance. It is generally described as a coronally-oriented fascial sheet separating the retropharyngeal space anteriorly from the danger space posteriorly. Read More

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http://dx.doi.org/10.1002/ca.23644DOI Listing

Comparing the Efficiency of Software-Based Speech Recognition Versus Traditional Telephone Transcription in an Outpatient Physical Medicine and Rehabilitation Practice.

Mil Med 2020 Jul 6. Epub 2020 Jul 6.

Alan Edwards Pain Management Unit, Canada.

Introduction: Speech recognition (SR) uses computerized word recognition software that automatically transcribes spoken words to written text. Some studies indicate that SR may improve efficiency of electronic charting as well as associated cost and turnaround time1,2, but it remains unclear in the literature whether SR is superior to traditional transcription (TT). This study compared the impact of report generation efficiency of SR to TT at the Canadian Armed Forces Health Services Centre. Read More

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http://dx.doi.org/10.1093/milmed/usz374DOI Listing

Macromolecular crystallography beamlines at the Canadian Light Source: building on success.

Acta Crystallogr D Struct Biol 2020 Jul 19;76(Pt 7):630-635. Epub 2020 Jun 19.

Canadian Macromolecular Crystallography Facility, Canadian Light Source, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada.

The Canadian Macromolecular Crystallography Facility (CMCF) consists of two beamlines dedicated to macromolecular crystallography: CMCF-ID and CMCF-BM. After the first experiments were conducted in 2006, the facility has seen a sharp increase in usage and has produced a significant amount of data for the Canadian crystallographic community. Upgrades aimed at increasing throughput and flux to support the next generation of more demanding experiments are currently under way or have recently been completed. Read More

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http://dx.doi.org/10.1107/S2059798320007603DOI Listing

Addressing embodied inequities in health: how do we enable improvement in women's diet in pregnancy?

Public Health Nutr 2020 Jul 6:1-11. Epub 2020 Jul 6.

Medical Research Council Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom of Great Britain and Northern Ireland.

Objective: To disrupt cycles of health inequity, traceable to dietary inequities in the earliest stages of life, public health interventions should target improving nutritional wellbeing in preconception/pregnancy environments. This requires a deep engagement with pregnant/postpartum people (PPP) and their communities (including their health and social care providers, HSCP). We sought to understand the factors that influence diet during pregnancy from the perspectives of PPP and HSCP, and to outline intervention priorities. Read More

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http://dx.doi.org/10.1017/S1368980020001093DOI Listing

COVID stress syndrome: Concept, structure, and correlates.

Depress Anxiety 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology, University of Regina, Regina, Saskatchewan, Canada.

Background: Research shows that the COVID Stress Scales have a robust multifactorial structure, representing five correlated facets of COVID-19-related distress: (a) Fear of the dangerousness of COVID-19, which includes fear of coming into contact with fomites potentially contaminated with SARSCoV2, (b) worry about socioeconomic costs of COVID-19 (e.g., worry about personal finances and disruption in the supply chain), (c) xenophobic fears that foreigners are spreading SARSCoV2, (d) traumatic stress symptoms associated with direct or vicarious traumatic exposure to COVID-19 (nightmares, intrusive thoughts, or images related to COVID-19), and (e) COVID-19-related compulsive checking and reassurance seeking. Read More

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http://dx.doi.org/10.1002/da.23071DOI Listing

Conducting fit-for-purpose food safety risk assessments.

EFSA J 2019 Jul 8;17(Suppl 1):e170707. Epub 2019 Jul 8.

Communication Engagement and Cooperation (COMCO) Department European Food Safety Authority (EFSA) Italy.

The interplay between science, risk assessment and risk management has always been complex, and even more so in a world increasingly characterised by rapid technical innovation, new modes of communication, suspicion about authorities and experts, and demands for people to have a say in decisions that are made on their behalf. In this challenging era where scientific advice on food safety has never been in greater demand, risk managers should effectively navigate the interplay between facts and values and be able to rely on robust and fit-for-purpose risk assessments to aid them. The fact that societal resistance is often encountered when scientific advice on food safety operates at a distance from social values and fails to actively engage with citizens, has led to increasing emphasis on the need to advance forms of risk assessment that are more contextual, and socially sound and accountable. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.e170707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015513PMC

Is a Long Non-coding RNA Locus That Regulates Expression.

Front Genet 2020 17;11:631. Epub 2020 Jun 17.

Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, ON, Canada.

Genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) most of them located in non-protein coding regions of the genome. One such locus is the CAD Associated Region between and (CARMA), a ∼18 kb haplotype that was recently shown to regulate vicinal protein coding genes. Here, we further investigate the region by examining a long non-coding RNA gene locus (RP11-326A19. Read More

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http://dx.doi.org/10.3389/fgene.2020.00631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311772PMC

An Unusual Enteritidis Strain Carrying a Modified Virulence Plasmid Lacking the Gene Represents a Geographically Widely Distributed Lineage.

Front Microbiol 2020 17;11:1322. Epub 2020 Jun 17.

Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, ON, Canada.

This study identifies a strain of subspecies serovar Enteritidis that harbors a highly unusual virulence plasmid. During the characterisation of a group of Enteritidis isolates, 10 isolates recovered from Canadian duck production facilities, of which seven were phage type 9b and three were closely related atypical phage types, failed detection by a PCR targeting the gene, a marker located on the virulence plasmid often employed for identification of this serovar. Comparison to + isolates by several standard genetic typing tools, further revealed their distinctive genomic makeup. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311658PMC

New data on the aphid (Hemiptera, Aphididae) fauna of New Caledonia: some new biosecurity threats in a biodiversity hotspot.

Zookeys 2020 22;943:53-89. Epub 2020 Jun 22.

Canadian National Collection of Insects, Agriculture and Agri-Food Canada/Agriculture et Agroalimentaire Canada Ottawa Research and Development Centre, K. W. Neatby Building 960 Carling Avenue, Ottawa, Ontario, K1a 0c6, Canada Agriculture and Agri-Food Canada/Agriculture et Agroalimentaire Canada Ottawa Research and Development Centre Ottawa Canada.

Thirty-three species of aphids are now established in New Caledonia. All species appear to have been introduced accidentally by human activity in the last century. Here, 17 aphid species are recorded for the first time: , , , , , , , , , , , , , , , , and . Read More

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http://dx.doi.org/10.3897/zookeys.943.47785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324436PMC

Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope.

Can J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada.

Syncope is a symptom that occurs in multiple settings and has a variety of underlying causes, ranging from benign to life threatening. Determining the underlying diagnosis and prognosis can be challenging and often results in an unstructured approach to evaluation, which is ineffective and costly. In this first ever document, the Canadian Cardiovascular Society (CCS) provides a clinical practice update on the assessment and management of syncope. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.023DOI Listing

A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

Transplant Proc 2020 Jul 2. Epub 2020 Jul 2.

Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada; Alberta Transplant Institute, Edmonton, AB, Canada; Canadian National Transplant Research Program, Edmonton, AB, Canada. Electronic address:

Background: Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate (CHIP) with equivalent functional and inflammatory characteristics to a standard Krebs-Henseleit buffer with 8% serum albumin-derived perfusate (KHB-Alb) to improve access and reduce costs of ex vivo organ perfusion.

Methods: Sixteen porcine lungs were perfused using negative pressure ventilation (NPV) EVLP for 12 hours in a normothermic state and were allocated equally to 2 groups: KHB-Alb vs CHIP. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.007DOI Listing

COVID-19 Pandemic: Perspective from Italian Pediatric Emergency Physicians.

Disaster Med Public Health Prep 2020 Jun 22:1-11. Epub 2020 Jun 22.

CRIMEDIM - Research Center in Emergency and Disaster Medicine, Università del Piemonte Orientale, Novara, Italy.

Objective: To document the lived experience of Italian pediatric emergency physicians during the COVID-19 pandemic.

Methods: We developed a structured interview to collect the lived experience of the staff of the Pediatric emergency department (PED) of a tertiary referral university hospital in Northern Italy. The open-ended questions were draft according to the suggestions of Canadian colleagues and administered by one interviewer, who was part of the PED staff, at the end of March 2020. Read More

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http://dx.doi.org/10.1017/dmp.2020.198DOI Listing

Prospective comparative evaluation of the European Society of Cardiology (ESC) 1-hour and a 2-hour rapid diagnostic algorithm for myocardial infarction using high-sensitivity troponin-T.

CJEM 2020 Jul 6:1-9. Epub 2020 Jul 6.

Department of Emergency Medicine.

Objective: Both 1- and 2-hour rapid diagnostic algorithms using high-sensitivity troponin (hs-cTn) have been validated to diagnose acute myocardial infarction (MI), leaving physicians uncertain which algorithm is preferable. The objective of this study was to prospectively evaluate the diagnostic performance of 1- and 2-hour algorithms in clinical practice in a Canadian emergency department (ED).

Methods: ED patients with chest pain had high-sensitivity cardiac troponin-T (hs-cTnT) collected on presentation and 1- and 2-hours later at a single academic centre over a 2-year period. Read More

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http://dx.doi.org/10.1017/cem.2020.349DOI Listing

Delta opioid receptor activation modulates affective pain and modality-specific pain hypersensitivity associated with chronic neuropathic pain.

J Neurosci Res 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology and Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models, including neuropathic pain, while having minimal effect on sensory thresholds in the absence of injury. The mechanisms underlying nerve injury-induced enhancement of DOR function are unclear. We used a peripheral nerve injury (PNI) model of neuropathic pain to assess changes in the function and localization of DORs in mice and rats. Read More

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http://dx.doi.org/10.1002/jnr.24680DOI Listing

Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.

Cardiovasc Drugs Ther 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose: Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annotation and functional studies.

Methods: Seventy ST cases on clopidogrel identified from the PLATO trial (n = 58) and Mayo Clinic biorepository (n = 12) were matched 1:1 with controls for age, race, sex, diabetes mellitus, presentation, and stent type. Read More

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http://dx.doi.org/10.1007/s10557-020-06988-wDOI Listing

The role of school characteristics in pre-legalization cannabis use change among Canadian youth: implications for policy and harm reduction.

Health Educ Res 2020 Jul 5. Epub 2020 Jul 5.

School of Public Health and Health Systems, University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, Canada.

Reducing youth cannabis use in Canada is a public health priority with schools of interest as a potential modifier of behavior and as a venue for prevention programming. This work aimed to provide a basis for future policy and programming by evaluating pre-legalization cannabis use change patterns in schools and the impact of school characteristics on these patterns. Average rates of cannabis use behavior change (initiation, escalation, reduction, cessation) were collected from 88 high schools located in Ontario and Alberta, Canada participating in the COMPASS prospective cohort study. Read More

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http://dx.doi.org/10.1093/her/cyaa018DOI Listing

Prevalence of abdominal obesity and associated lifestyle factors in bus drivers in a city in Southern Brazil.

Work 2020 Jun 27. Epub 2020 Jun 27.

Universidade Federal de Santa Catarina, Núcleo de Pesquisa em Cineantropometria e Desempenho Humano, Florianópolis, Santa Catarina, Brasil.

Background: Bus drivers are exposed to unique working conditions. However, the behavioral and health trends of these workers should be investigated.

Objective: To estimate the prevalence of abdominal obesity and associated lifestyle factors in bus drivers in a city in southern Brazil. Read More

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http://dx.doi.org/10.3233/WOR-203200DOI Listing

Effects of Probiotic Supplementation on Short Chain Fatty Acids in the AppNL-G-F Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2020 Jun 29. Epub 2020 Jun 29.

Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA.

Background: The intestinal microbiota and its metabolites, particularly short-chain fatty acids (SCFAs), have been implicated in immune function, host metabolism, and even behavior.

Objective: This study was performed to investigate whether probiotic administration influences levels of intestinal microbiota and their metabolites in a fashion that may attenuate brain changes in a mouse model of Alzheimer's disease (AD).

Methods: C57BL/6 wild-type (WT) mice were compared to AppNL-G-Fmice. Read More

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http://dx.doi.org/10.3233/JAD-200436DOI Listing

Recent Trends in Hospitalizations for Cardiovascular Disease, Stroke, and Vascular Cognitive Impairment in Canada.

Can J Cardiol 2020 Jun 18. Epub 2020 Jun 18.

Heart and Stroke Foundation of Canada, Toronto, Ontario, Canada. Electronic address:

Background: We analyzed hospitalization rates for a broad set of cardiovascular diseases, stroke, and vascular cognitive impairment (VCI) between 2007 and 2016 in Canada to characterize population-level trends and demographic and provincial/territorial variation in inpatient health care utilization.

Methods: Record-level administrative hospitalization data from April 1, 2007 to March 31, 2017 for individuals aged 0-105 years were obtained from the Canadian Institute for Health Information Discharge Abstract Database. Data were available for all provinces and territories, except Quebec. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.03.007DOI Listing

From Complexity to Consciousness.

Trends Neurosci 2020 Jun 24. Epub 2020 Jun 24.

Canadian Institute for Advanced Research, Azrieli Program in Brain, Mind, and Consciousness, Toronto, Canada; Department of Biomedical Clinical Sciences, University of Milan, Milan, Italy; IRCCS, Fondazione Don Gnocchi, Milan, Italy.

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http://dx.doi.org/10.1016/j.tins.2020.05.008DOI Listing

The impact of emergency department triage on the treatment outcomes of cancer patients with febrile neutropenia: A retrospective review.

Int Emerg Nurs 2020 Jul 1;51:100888. Epub 2020 Jul 1.

MUN School of Medicine, St. John's, Canada. Electronic address:

Introduction: The emergency department (ED) is an important entry point for patients with cancer requiring acute care due to oncological emergencies. Febrile neutropenia (FN) is one of the most common oncological emergencies and carries a significant risk of morbidity and mortality. There is evidence from previous studies that FN patients wait far longer in the ED than recommended by international guidelines. Read More

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http://dx.doi.org/10.1016/j.ienj.2020.100888DOI Listing

Association Between HbA Levels and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Cardiovascular Disease: A Secondary Analysis of the TECOS Randomized Clinical Trial.

Eur J Heart Fail 2020 Jul 4. Epub 2020 Jul 4.

Diabetes Trials Unit, University of Oxford, Oxford, UK.

Aims: Whether glycemic control is associated with cardiovascular outcomes in patients with type 2 diabetes (T2D) is unclear. Consequently, we assessed the relationship between glycated hemoglobin (HbA ) and cardiovascular outcomes in a placebo-controlled randomized trial which demonstrated no cardiovascular effect of sitagliptin in patients with T2D and atherosclerotic vascular disease.

Methods And Results: Secondary analysis of 14,656 TECOS participants with time to event analyses using multivariable Cox proportional hazard models. Read More

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http://dx.doi.org/10.1002/ejhf.1958DOI Listing

Diagnostic accuracy of cognitive screening tools under different neuropsychological definitions for poststroke cognitive impairment.

Brain Behav 2020 Jul 3:e01671. Epub 2020 Jul 3.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: The accuracy of cognitive screening tools to detect poststroke cognitive impairment (PSCI) was investigated using various neuropsychological definitions.

Methods: Hospital-based stroke patients underwent a comprehensive neuropsychological assessment. The rate of PSCI was estimated using thresholds of 1, 1. Read More

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http://dx.doi.org/10.1002/brb3.1671DOI Listing

Assessing New Zealand's Cannabis Legalization and Control Bill: prospects and challenges.

Addiction 2020 Jul 4. Epub 2020 Jul 4.

SHORE & Whariki Research Centre, Massey University, P.O. Box 6137, Victoria Street West, Auckland, 1142, New Zealand.

Background: Few countries have developed detailed legislative proposals for legalizing cannabis. New Zealand recently released the Cannabis Legalization and Control Bill (CLCB) that will be the subject of a referendum in September 2020.

Aims: To assess the CLCB, drawing on emerging evidence from cannabis legalization overseas, public health research on alcohol and tobacco and the attempt to establish a regulated market for 'legal highs' in New Zealand. Read More

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http://dx.doi.org/10.1111/add.15144DOI Listing

Review article: prognostic significance of body composition abnormalities in patients with cirrhosis.

Aliment Pharmacol Ther 2020 Jul 3. Epub 2020 Jul 3.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, AB, Canada.

Background: Recent advances in evaluation of body composition show body mass index to be inadequate in differentiating between body compartments in cirrhosis. Given the limitations of body mass index, body composition evaluation using computed tomography has been increasingly used as a non-invasive clinical tool with prognostic value. Another factor influencing prognosis includes sex-specific differences in body composition that are seen in cirrhosis. Read More

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http://dx.doi.org/10.1111/apt.15927DOI Listing

Conscious perception and the modulatory role of dopamine: no effect of the dopamine D2 agonist cabergoline on visual masking, the attentional blink, and probabilistic discrimination.

Psychopharmacology (Berl) 2020 Jul 3. Epub 2020 Jul 3.

Department of Experimental and Applied Psychology, Institute for Brain and Behavior Amsterdam (iBBA) Vrije Universiteit, Amsterdam, Netherlands.

Rationale: Conscious perception is thought to depend on global amplification of sensory input. In recent years, striatal dopamine has been proposed to be involved in gating information and conscious access, due to its modulatory influence on thalamocortical connectivity.

Objectives: Since much of the evidence that implicates striatal dopamine is correlational, we conducted a double-blind crossover pharmacological study in which we administered cabergoline-a dopamine D2 agonist-and placebo to 30 healthy participants. Read More

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http://dx.doi.org/10.1007/s00213-020-05579-9DOI Listing

Clinical Learning, Didactic Education, and Research Experiences of Radiation Oncology Resident Physicians in Canada.

J Cancer Educ 2020 Jul 4. Epub 2020 Jul 4.

Division of Radiation Oncology, University of Alberta, Edmonton, AB, Canada.

Changes in the field of radiation oncology (RO) impacts residency training. Assessing trainee experiences is essential to inform curriculum development. We aim to explore gaps and strengths in current Canadian RO training, as we move towards competency-based medical education (CBME). Read More

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http://dx.doi.org/10.1007/s13187-020-01799-xDOI Listing

π covalency in the halogen bond.

Nat Commun 2020 Jul 3;11(1):3310. Epub 2020 Jul 3.

Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.

Halogen bonds are a highly directional class of intermolecular interactions widely employed in chemistry and chemical biology. This linear interaction is commonly viewed to be analogous to the hydrogen bond because hydrogen bonding models also intuitively describe the σ-symmetric component of halogen bonding. The possibility of π-covalency in a halogen bond is not contemplated in any known models. Read More

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http://dx.doi.org/10.1038/s41467-020-17122-7DOI Listing

Comparison of two methods to clear the airways of critically ill children and adults with COVID-19 infection: a structured summary of a study protocol for a pilot randomized controlled trial.

Trials 2020 Jul 3;21(1):610. Epub 2020 Jul 3.

Department of Pediatrics, University of Montreal, CHU Sainte-Justine, 3175 Chemin de Côte Sainte Catherine, Quebec, QB, H3T 1C5, Canada.

Objectives: As there is no treatment for COVID-19 with a proven mortality benefit at this moment in the pandemic, supportive management including mechanical ventilation is the core management in an intensive care unit (ICU). It is a challenge to provide consistent care in this situation, highly demanding and leading to potential staff shortages in ICU. We need to reduce unnecessary exposure of healthcare workers to the virus. Read More

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http://dx.doi.org/10.1186/s13063-020-04533-6DOI Listing

Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.

Expert Rev Clin Immunol 2020 Jul 3. Epub 2020 Jul 3.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School , Boston, MA, USA.

Introduction: Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public. Read More

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http://dx.doi.org/10.1080/1744666X.2020.1792778DOI Listing

Substance use disorders among youth with chronic physical illness.

Addict Behav 2020 Jun 23;110:106517. Epub 2020 Jun 23.

School of Public Health & Health Systems, University of Waterloo, Waterloo, Canada. Electronic address:

This study estimated prevalence of substance use disorder in youth with chronic physical illness; quantified magnitudes of association between different chronic physical illnesses with substance use disorder; and, tested whether mental disorder moderates these associations. Data come from 6,377 individuals aged 15-30 years in the Canadian Community Health Survey-Mental Health. Alcohol, cannabis, or other drug use disorder measured using the WHO Composite International Diagnostic Interview 3. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106517DOI Listing

Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial.

Am J Gastroenterol 2020 Jul;115(7):1055-1065

Department of Microbiology and Immunology, Western University, London, Ontario, Canada.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is an obesity-related disorder that is rapidly increasing in incidence and is considered the hepatic manifestation of the metabolic syndrome. The gut microbiome plays a role in metabolism and maintaining gut barrier integrity. Studies have found differences in the microbiota between NAFLD and healthy patients and increased intestinal permeability in patients with NAFLD. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000661DOI Listing

Exploring the Contributions of Combined Model Regional Medical Education Campuses to the Physician Workforce.

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

J. Bates was professor emerita, Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada, at the time this work was done. ORCID: http://orcid.org/0000-0001-6940-2946. P. Grand'Maison is professor, Departments of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. S.R. Banner was CEO, Canadian Resident Matching Service, from 1986-2016, and is Director of Admissions for Canada, St. George's Medical School, Ottawa, Ontario, Canada. C.Y. Lovato is professor, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. K.W. Eva is professor and director of education research and scholarship, Department of Medicine, and associate director and senior scientist, Centre for Health Education Scholarship, University of British Columbia, Vancouver, British Columbia, Canada. ORCID: http://orcid.org/0000-0002-8672-2500.

Purpose: Physician shortages and maldistribution, particularly within family medicine, have led many medical schools worldwide to create regional medical campuses (RMCs) for clerkship training. However, Canadian medical schools have developed a number of RMCs in which all years of training (i.e. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003560DOI Listing

CAEP Joint Position Statement - Management of devastating brain injuries in the emergency department: Enhancing neuroprognostication and maintaining the opportunity for organ and tissue donation.

CJEM 2020 Jun 19:1-3. Epub 2020 Jun 19.

Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC.

The primary purpose of this statement is to improve neuroprognostication after devastating brain injury (DBI), with a secondary benefit of potential organ and tissue donation. Read More

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http://dx.doi.org/10.1017/cem.2020.357DOI Listing

The Canadian Occupational Performance Measure (COPM): a valuable tool for children with cerebral paresis.

Dev Med Child Neurol 2020 Jul 3. Epub 2020 Jul 3.

Occupational Therapy Department, Institute of Therapist and Midwifery, The Faculty of Health Sciences, Copenhagen University College, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dmcn.14617DOI Listing

Computer-guided implant surgery: analysis of dynamic navigation systems and digital accuracy.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):9-17

Dept. of social dentistry and gnathological rehabilitation, National Institute for Health, Migration and Poverty (NIHMP), Roma, Italy.

After the static computer-guided implant surgery, borns the concept of "navigated implantology" (NI) that offers significant advantages in the treatment planning and help clinicians to perform successful implant rehabilitation. NI allows an optimal final location, to avoid the risk of damaging the noble anatomical structures near the site and allows the achievement of satisfactory aesthetics. The aim of this study is analyze three different systems: the RoboDent® system (Berlin, Germany, 2001), today not for sale, was the first implant navigation system introduced on the market and made the history of dynamic surgery; X-Guide (Nobel Biocare, 2017), a dynamic computer assisted system that uses the principles of stereoscopic triangulation by optical video cameras. Read More

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Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice.

J Cell Physiol 2020 Jul 2. Epub 2020 Jul 2.

Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.

This study investigated whether regulation of the renin-angiotensin system (RAS) by enalapril and/or aerobic exercise training (AET) causes browning of the subcutaneous white adipose tissue (sWAT). C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At Week 8, HF-fed animals were divided into sedentary (HF), enalapril (HF-E), AET (HF-T), and enalapril plus AET (HF-ET) groups. Read More

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http://dx.doi.org/10.1002/jcp.29900DOI Listing

Impacts of low salinity exposure and antibiotic application on gut transport activity in the Pacific spiny dogfish, Squalus acanthias suckleyi.

J Comp Physiol B 2020 Jul 2. Epub 2020 Jul 2.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.

The role of the marine elasmobranch gastrointestinal tract in nitrogen-recycling and osmotic homeostasis has become increasingly apparent, with the gut microbial community likely playing a significant role converting urea, an important osmolyte in elasmobranchs, into ammonia. The Pacific spiny dogfish can experience and tolerate reduced environmental salinities, yet how this environmental challenge may affect the microbiome, and consequently nitrogen transport across the gut, is as of yet unknown. In the present study, excised gut sac preparations were made from dogfish acclimated to the following: full-strength seawater (C), low salinity for 7 days (LS), and after acute transfer of LS-acclimated fish to full-strength SW for 6 h (AT). Read More

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http://dx.doi.org/10.1007/s00360-020-01291-4DOI Listing

Black PRAISE: engaging Black congregations to strengthen critical awareness of HIV affecting Black Canadian communities.

Health Promot Int 2020 Jul 2. Epub 2020 Jul 2.

Meritus Medical Centre, Inc., 11116 Medical Campus Road, Suite 2904, Hagerstown, MD 21742, USA.

In Canada, HIV disproportionately affects Black communities. Though Black faith leaders play an influential role engaging Black communities around social care and social justice, their response to HIV has been somewhat muted. Black PRAISE is a novel intervention for Black churches to strengthen congregants' critical awareness of HIV affecting Black communities. Read More

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http://dx.doi.org/10.1093/heapro/daaa057DOI Listing

Influences for Gender Disparity in Academic Family Medicine in North American Medical Schools.

Cureus 2020 May 30;12(5):e8368. Epub 2020 May 30.

Radiology, Vancouver General Hospital, Vancouver, CAN.

Background Women physicians continue to comprise the minority of leadership roles in Academic Family Medicine (AFM) faculty across North American medical schools. Our study quantified the current state of gender disparity by analyzing academic position, leadership ranking, and research productivity. Methods We generated a database for 6,746 AFM faculty members. Read More

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http://dx.doi.org/10.7759/cureus.8368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326302PMC

Recognition of Advanced Practice Pharmacists in Australia and Beyond: Considerations for Canadian Practitioners.

Can J Hosp Pharm 2020 May-Jun;73(3):225-231. Epub 2020 Jun 1.

, BPharm, MClinPharm, AdvPracPharm, is with the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308161PMC

Practical Guidance in Perioperative Management of Immunosuppressive Therapy for Rheumatology Patients Undergoing Elective Surgery.

Can J Hosp Pharm 2020 May-Jun;73(3):218-224. Epub 2020 Jun 1.

, BPharm, MSc, RPh, is with The Ottawa Hospital, Ottawa, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308162PMC

Vasopressin for Septic Shock in a Medical-Surgical Intensive Care Unit.

Can J Hosp Pharm 2020 May-Jun;73(3):209-215. Epub 2020 Jun 1.

, BSc, BSc(Pharm), ACPR, is with the Department of Pharmacy Services and the Department of Emergency Medicine, Surrey Memorial Hospital, Surrey, British Columbia.

Background: Critically ill patients often need vasopressors to treat hypotension related to septic shock and to maintain adequate systemic perfusion. Although the 2017 guidelines of the Surviving Sepsis Campaign recommend norepinephrine as first-line therapy, they also state that vasopressin may be considered as an adjunctive agent for patients with refractory shock. Limited evidence is available for directing optimal administration of vasopressin. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308152PMC

The identification of sulfide oxidation as a potential metabolism driving primary production on late Noachian Mars.

Sci Rep 2020 Jul 2;10(1):10941. Epub 2020 Jul 2.

AstrobiologyOU, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, UK.

The transition of the martian climate from the wet Noachian era to the dry Hesperian (4.1-3.0 Gya) likely resulted in saline surface waters that were rich in sulfur species. Read More

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http://dx.doi.org/10.1038/s41598-020-67815-8DOI Listing