2,121 results match your criteria Canadian Journal of Urology[Journal]


Wunderlich syndrome secondary to cyst rupture and concurrent anticoagulation.

Can J Urol 2020 Jun;27(3):10270-10272

Department of Urology, Tan Tock Seng Hospital, Singapore.

Wunderlich syndrome (WS) is a rare triad of flank pain, flank mass and hypovolemic shock and is classically attributed to angiomyolipomata or neoplasms. Treatment is guided by clinical severity: conservative, selective arterial embolization, or nephrectomy. We report an atypical case of a 69-year old man with a pre-existing 9 cm left renal tumor who developed WS secondary to anticoagulation and simple cyst rupture from his contralateral kidney, complicated by abdominal compartment syndrome with hemodynamic instability despite inotropic support and robust resuscitation. Read More

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Single port robotic radical prostatectomy with the da Vinci SP platform: a step by step approach.

Can J Urol 2020 Jun;27(3):10263-10269

Department of Urology, University of Illinois at Chicago, Chicago, Illinois, USA.

The da Vinci single port (SP) robotic system (Intuitive Surgical, Sunnyvale, CA, USA) is a recently approved robotic platform designed with several modifications to the previously available multi-port robotic systems. This article describes the technique performed utilizing the SP robotic system for radical robotic-assisted laparoscopic prostatectomy (RALP) with or without bilateral pelvic lymph node dissection from a single institution. In this report we describe our step-by-step approach, technical modifications from the multi-port technique and initial results for performing single port robotic-assisted laparoscopic prostatectomy (SP-RALP). Read More

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Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis.

Can J Urol 2020 Jun;27(3):10257-10262

Department of Urology/Pelvic Health, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis are coexistent diagnoses in 48%-65% of women with chronic pelvic pain (CPP), suggesting that dual screening may be warranted. To further investigate the clinical relationship and risk factors between these two conditions, we performed a retrospective review of our large IC/BPS patient data registry.

Materials And Methods: We evaluated IC/BPS patients who were prospectively enrolled into our registry who completed validated questionnaires and underwent therapeutic hydrodistension, during which anesthetic bladder capacity (BC) and Hunner's lesion (HL) status were recorded. Read More

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Simple frameshifts in minimally invasive surgery postoperative pain management significantly reduce opiate prescriptions.

Can J Urol 2020 Jun;27(3):10250-10256

Department of Urology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Introduction: To evaluate the impact of an 'opt-in' non-narcotic postoperative pain regimen on narcotic utilization and patient-reported pain scores.

Materials And Methods: A prospective, non-blinded pre- and post-interventional trial was conducted, including a lead-in period for baseline evaluation. The intervention group received a new pain protocol prioritizing non-narcotic medications, an 'opt-in' requirement for opiates, and standardized patient education. Read More

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Urodynamics less likely to change diagnosis and management in uncomplicated overactive bladder.

Can J Urol 2020 Jun;27(3):10244-10249

Albert Einstein College of Medicine, Bronx, New York, USA.

Introduction: Given the invasive nature of urodynamics and its unclear impact on altering patient management, we aimed to determine whether performing a urodynamic study (UDS) resulted in a change in either patient diagnosis or treatment offered in women with uncomplicated urinary incontinence.

Materials And Methods: A retrospective review was performed of all female patients who underwent UDS for urinary incontinence at our practice between January 2014 and 2017. Patients with neurogenic lower urinary tract dysfunction, incomplete emptying, urinary retention, or prior anti-incontinence surgery were excluded. Read More

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Understanding the relationship between health insurance and kidney stones: an examination of NHANES data.

Can J Urol 2020 Jun;27(3):10238-10243

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

Introduction: To investigate the relationship between socioeconomic factors, specifically insurance status, and kidney stones using a nationally representative cohort.

Materials And Methods: A retrospective secondary data analysis of National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2014 was performed. Using univariate statistics and multiple logistic regressions, we examined the relationship between socioeconomic factors and kidney stone history. Read More

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A history of urolithiasis risk in space.

Can J Urol 2020 Jun;27(3):10233-10237

Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Introduction: The development of renal stones in space would not only impact the health of an astronaut but could critically affect the success of the mission.

Materials And Methods: We reviewed the medical literature, texts and multimedia sources regarding the careers of Dr. Abraham Cockett and Dr. Read More

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Pediatric cystoscopy of male urethral strictures: an accurate and useful preoperative surgical decision making tool.

Can J Urol 2020 Jun;27(3):10228-10232

Washington University School of Medicine, St. Louis, Missouri, USA.

Introduction: To evaluate flexible pediatric cystoscopy (FPC) as an adjunctive procedure to retrograde urethrography (RUG) and voiding cystourethrography (VCUG) in the preoperative setting for male urethral strictures. Since imaging interpretation of stricture length and caliber can be difficult at times, we sought to evaluate diagnostic utility of FPC to predict reconstructive surgery.

Materials And Methods: Reconstructive urology databases at Washington University and Columbia University were queried from 2010-2017. Read More

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Prospective evaluation of the value of dynamic contrast enhanced (DCE) imaging for prostate cancer detection, with pathology correlation.

Can J Urol 2020 Jun;27(3):10220-10227

Department of Radiology, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.

Introduction: The aim of this study was to evaluate the value of dynamic contrast enhanced (DCE) imaging in multi-parametric prostate MRI (mpMRI) for the detection and staging of prostate cancer in comparison with T2W and DWI images alone in biparametric MRI (bpMRI) in treatment naïve patients.

Materials And Methods: One hundred consecutive patients who underwent a prostate MRI at our institution from June-August 2017, as well as a systematic ultrasound-guided prostate biopsy or prostatectomy, were included. Strictly following PIRADSv2, the MRI studies were independently interpreted by a body radiologist and a body-imaging fellow on two different occasions 8-10 weeks apart. Read More

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Early patient experience following treatment with the UroLift prostatic urethral lift and Rezum steam injection.

Can J Urol 2020 Jun;27(3):10213-10219

Chesapeake Urology Research Associates, Baltimore, Maryland, USA.

Introduction: To report the early postoperative patient experience, including symptom response, catheterization, recovery and satisfaction, following treatment with two minimally invasive surgical therapies (MIST) for benign prostatic hyperplasia (BPH): mechanical disobstruction with UroLift prostatic urethral lift (PUL) and tissue ablation with steam injection (Rezum).

Materials And Methods: Patient reported outcomes of 53 non-retention patients from two U.S. Read More

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Urological implications of SARS CoV-19.

Can J Urol 2020 06;27(3):10205-10212

Department of Urology and Robotic Surgery, Sir Ganga Ram Hospital, New Delhi, India.

Introduction: The novel coronavirus disease 2019 (COVID-19), pandemic has afflicted > 3.3 million people around the world since December 2019. Though, more than 1000 publications have appeared in scientific journals addressing a plethora of questions, there is a considerable hiatus in understanding of the behavior and natural history of the virus and its impact on urology. Read More

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June 2020
0.905 Impact Factor

Legends in Urology.

Authors:
Alan J Wein

Can J Urol 2020 Jun;27(3):10201-10204

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania USA.

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Burnout in Urology and the Hidden Workplace Dangers.

Can J Urol 2020 Jun;27(3):10199-10200

Thomas Jefferson University, Philadelphia, USA.

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Gas in the inferior vena cava from severe emphysematous pyelonephritis.

Can J Urol 2020 Apr;27(2):10195-10198

Division of Urology, University of Ottawa, Ottawa, Ontario, Canada.

Emphysematous pyelonephritis is a life-threatening, urologic emergency. We present the case of a 54-yearold female who was found to have a large volume of air in her renal vein and inferior vena cava from severe emphysematous pyelonephritis. In this case report, the medical and operative management of this patient are reviewed, and the literature on the management of emphysematous pyelonephritis is summarized. Read More

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Cavernous hemangioma of the adrenal gland mimicking a hepatic hemangioma.

Can J Urol 2020 Apr;27(2):10192-10194

Department of Urology, Queen's University, Kingston, Ontario.

Adrenal cavernous hemangiomas are a rare, benign, and non-functional tumor. We report a case of a 62-year-old male who presented with right upper quadrant and flank pain. Physical examination revealed a fullness of the right upper quadrant. Read More

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How I Do It - MRI-ultrasound fusion prostate biopsy using the Fusion MR and Fusion Bx systems.

Can J Urol 2020 Apr;27(2):10185-10191

University of Toronto, Department of Surgery, Toronto, Ontario, Canada.

There is increasing evidence to support the use of multiparametric magnetic resonance imaging (MRI) in men at risk for clinically significant prostate cancer to help identify lesions and inform biopsy. Randomized, level 1 evidence demonstrates that men who are managed with MRI and MRI-ultrasound fusion targeted biopsy (MRF-TB) have more clinically significant prostate cancer and less clinically insignificant prostate cancer detected and avoid biopsy altogether more often than men who undergo systematic, whole-gland prostate biopsy (SPB). Furthermore, strategies that incorporate MRF-TB have lower rates of upgrading on radical prostatectomy compared to SPB. Read More

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Prednisone after vasectomy reversal may improve semen parameters: one institution's experience.

Can J Urol 2020 Apr;27(2):10181-10184

Department of Urology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Introduction: Patients with suboptimal semen parameters following vasectomy reversal represent a diagnostic and therapeutic challenge. This may be caused by either partial or complete anastomotic obstruction. Despite the relatively common clinical use of corticosteroids in this patient population, data remain sparse. Read More

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Guidewire type and prior use affects ureteral stent insertion force.

Can J Urol 2020 Apr;27(2):10174-10180

Loma Linda University School of Medicine, Loma Linda, California, USA.

Introduction: To improve the success rate and safety of ureteral stent insertion, we sought to identify the effect of guidewire type and prior use upon the force needed to advance a 6Fr ureteral stent over various guidewires.

Materials And Methods: Two-hundred forty stent insertion trials were performed in an ex vivo porcine urinary tract model. Ten trials were randomly performed over 12 new and 12 used guidewires. Read More

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The role of FSH and LH in prostate cancer and cardiometabolic comorbidities.

Can J Urol 2020 Apr;27(2):10167-10173

Division of Urology, University of California San Diego, La Jolla, California, USA.

Introduction: In this article we advance a potential explanation for the incidence of cardiovascular (CV) and cardiometabolic risk in patients undergoing androgen deprivation therapy (ADT) for prostate cancer. Our conceptual model involves the differential impact of gonadotropin-releasing hormone (GnRH) agonists and antagonists on the follicle-stimulating hormone (FSH) system.

Materials And Methods: Authors searched online repositories and meeting abstract databases for relevant materials. Read More

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Phyllanthus niruri (stone breaker) herbal therapy for kidney stones; a systematic review and meta-analysis of clinical efficacy, and Google Trends analysis of public interest.

Can J Urol 2020 Apr;27(2):10162-10166

Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.

Introduction: Phyllanthus niruri (P. niruri) is the most commonly listed active ingredient in commercially available herbal therapies for kidney stones, despite limited supporting clinical evidence. We performed a meta-analysis to evaluate its efficacy in reducing stone burden. Read More

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Charlson Comorbidity score influence on prostate cancer survival and radiation-related toxicity.

Can J Urol 2020 Apr;27(2):10154-10161

Department of Radiation Oncology, Henry Ford Cancer Institute, Detroit, Michigan, USA.

Introduction: In addition to survival endpoints, we explored the impact of Charlson Comorbidity-Index (CCI) on the acute and late toxicities in men with localized prostate cancer who received dose-escalated definitive radiotherapy (RT).

Materials And Methods: CCI scores at diagnosis and survival outcomes were identified for men with intermediate/high-risk prostate cancer treated with RT (1/2007-12/2012). Study-cohort was accordingly grouped into no, mild and severe comorbidity (CCI-0, 1 or 2+). Read More

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Aquablation for benign prostatic hyperplasia in large prostates (80-150 cc): 2-year results.

Can J Urol 2020 Apr;27(2):10147-10153

University of Southern California, Institute of Urology, Los Angeles, California, USA.

Introduction: To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates.

Materials And Methods: Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent an ultrasound-guided robotically executed Aquablation procedure in a prospective multicenter international clinical trial (WATER II). Baseline, procedural and follow up parameters were recorded at baseline and scheduled postoperative visits. Read More

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Legends in Urology.

Authors:
Ralph V Clayman

Can J Urol 2020 Apr;27(2):10144-10146

University of California, Irvine, Department of Urology, Orange, CA USA.

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The Nobel Prize; An Exclamation Point For Urologic Practice.

Authors:
Kevin R Loughlin

Can J Urol 2020 Apr;27(2):10142-10143

Harvard Medical School, Boston, MA USA.

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Management of erectile dysfunction and LUTS/incontinence: the two most common, long-term side effects of prostate cancer treatment.

Can J Urol 2020 Feb;27(1S1):17-24

Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. Read More

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February 2020

Androgen deprivation therapy: indications, methods of utilization, side effects and their management.

Can J Urol 2020 Feb;27(1S1):11-16

Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Our objective is to provide an up-to-date summary of current literature on the indications for androgen deprivation therapy (ADT), ways in which ADT is used, and the main side effects associated with its use. MEDLINE (Pubmed) was searched for relevant papers published from database inception to May 1, 2019 for studies evaluating the use of ADT and its associated adverse events. ADT is a mainstay in the treatment of prostate cancer and is used throughout the disease course. Read More

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February 2020

Diagnosis of prostate cancer: the implications and proper utilization of PSA and its variants; indications and use of MRI and biomarkers.

Can J Urol 2020 Feb;27(1S1):3-10

Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Prostate cancer screening remains highly controversial in medicine. The College of Family Physicians of Canada currently endorses positions that recommend against prostate-specific antigen (PSA) screening in men of all ages, while the Canadian Urological Association recommends shared and informed decision making for PSA screening in men 50-70 years old. Unfortunately, these opposing stances have left Family Physicians responsible for interpreting the appropriate course of action for their patients. Read More

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February 2020

The Primary Care Provider (Family Physician and Nurse Practitioner)-Specialist: Partnership.

Authors:
Jack Barkin

Can J Urol 2020 Feb;27(1S1):1-2

Clinical Professor, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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February 2020

Life-threatening gross hematuria: case report of renal artery aneurysm.

Can J Urol 2020 Feb;27(1):10138-10141

Department of Urology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, USA.

Renal artery aneurysms can present with gross hematuria and are potentially life-threatening in cases of rupture. We report a case of a young male with no prior genitourinary history who presents to an emergency department with sudden onset gross hematuria, clot retention, and right-sided flank pain. On evaluation, he was found to have a renal artery aneurysm bleeding into his collecting system and underwent renal artery embolization and rapid resolution of his hematuria. Read More

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February 2020

Testicular torsion in brothers.

Can J Urol 2020 Feb;27(1):10135-10137

Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Testicular torsion is a common pediatric emergency. Predisposing factors and other risk factors for testicular torsion have not been fully elucidated. This case report highlights teenage brothers who each experienced right-sided testicular torsion at nearly the same age, just 1 year apart. Read More

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February 2020

Safety of retrograde pyelography for infected ureteral stones.

Can J Urol 2020 Feb;27(1):10130-10134

Department of Urology, Detroit Medical Center, Detroit, Michigan, USA.

Introduction: Initial management of obstructing ureteral stones with concomitant urinary tract infection (UTI) includes prompt renal decompression and antibiotics. Some urologists theorize that performing retrograde pyelography (RGP) at the time of ureteral stent placement may cause pyelovenous backflow of bacteria thereby worsening clinical outcomes. We compared outcomes in patients with infected ureteral stones who underwent RGP versus no RGP prior to stent placement. Read More

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February 2020

Injection location does not impact botulinum toxin A efficacy in interstitial cystitis/bladder pain syndrome patients.

Can J Urol 2020 Feb;27(1):10125-10129

Department of Urology/Female Pelvic Health, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Introduction: Botulinum toxin A (BTX-A) is currently used as a fourth-line therapeutic option for interstitial cystitis/bladder pain syndrome (IC/BPS) management. The purpose of this study was to determine if BTX-A injection can mitigate pain and if injection location (i.e. Read More

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February 2020

Urinary leak following partial nephrectomy: a contemporary review of 975 cases.

Can J Urol 2020 Feb;27(1):10118-10124

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Introduction: To describe the incidence, contemporary management, risk factors and outcomes of urinary leak following open and robotic partial nephrectomy at a tertiary care, comprehensive cancer center.

Materials And Methods: We reviewed 975 patients who underwent partial nephrectomy at Moffitt Cancer Center from January 2009 to May 2017. Patient demographic, perioperative and follow up data was recorded and compared stratified for postoperative urine leak. Read More

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February 2020

Mirabegron improves sleep measures, nocturia, and lower urinary tract symptoms in those with urinary symptoms associated with disordered sleep.

Can J Urol 2020 Feb;27(1):10106-10117

Division of Urology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.

Introduction: The role of organized sleep in overall health and quality-of-life (QoL) is critical. Nocturia necessarily disrupts the normal sleep cycle and negatively impacts one's health, work productivity, and QoL. We investigated, for the first time in an exploratory pilot, the effectiveness of mirabegron for improving sleep disturbance and nocturia. Read More

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February 2020

Considerations and alternative approaches to antibiotic prophylaxis for prostate biopsy.

Can J Urol 2020 Feb;27(1):10105

Department of Urology, Washington University School of Medicine, St. Louis, Missouri, USA.

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February 2020

Hospital-specific antibiograms and antibiotic prophylaxis for prostate biopsies: a reexamination of AUA recommendations.

Can J Urol 2020 Feb;27(1):10099-10104

Department of Urology, Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Introduction: To assess whether standard American Urological Association (AUA) and other recommendations for prostate biopsy prophylaxis provide sufficient coverage of common urinary organisms responsible for post biopsy infections by comparing local antibiograms in Philadelphia-area hospitals.

Materials And Methods: De-identified culture results derived from antibiograms were collected from six academic and community hospitals in the Philadelphia region. Analysis specifically focused on four major bacterial causes of urinary tract infection following prostate biopsy (Escherichia coli (E. Read More

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February 2020

Continent cutaneous ileocecal cystoplasty in the treatment of refractory bladder neck contracture and urinary incontinence after prostate cancer treatment.

Can J Urol 2020 Feb;27(1):10093-10098

Department of Surgery, Division of Urology and Urologic Oncology, City of Hope National Medical Center, Duarte, California, USA.

Introduction: To assess the use, complications, and outcomes of continent cutaneous ileocecal cystoplasty (CCIC) for the management of refractory bladder neck contractures and/or urinary incontinence after prostate cancer therapy.

Materials And Methods: An institutional review board approved database was reviewed for patients who underwent CCIC from January 1, 2003 to December 31, 2018. Preoperative, perioperative and postoperative factors were assessed, including complications and outcomes. Read More

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February 2020

Implementing a patient safety culture survey to identify and target process improvements in academic ambulatory urology practices: a multi-institutional collaborative.

Can J Urol 2020 Feb;27(1):10087-10092

Division of Urology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Introduction: A shared professional culture focused on patient safety is critical to delivering high-quality care. There is a need for objective metrics to help identify target areas for improvement in patient safety culture. The Medical Office Survey on Patient Safety Culture (SOPS) was developed and validated by the United States Agency for Healthcare Research and Quality to measure patient safety culture in the ambulatory setting. Read More

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February 2020

Secondary screening tests for prostate cancer: is more information better? Which test is best?

Authors:
Judd W Moul

Can J Urol 2020 Feb;27(1):10086

Division of Urology, Department of Surgery, Duke University, Durham, North Carolina, USA.

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February 2020

Assessment of high-grade prostate cancer risk using prostate cancer biomarkers.

Can J Urol 2020 Feb;27(1):10080-10085

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Introduction: To identify patients at risk of high-grade prostate cancer using prostate cancer biomarkers.

Materials And Methods: A total of 601 men were screened for prostate cancer in 2012, 2015, and 2016 using prostate cancer biomarkers: prostate health index (phi), 4KScore, and SelectMDx. The first two are blood tests that incorporate several PSA isoforms; SelectMDx measures mRNA levels of homeobox C6 and distal-less homeobox 1 in post-digital rectal examination urine samples. Read More

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February 2020

Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial.

Can J Urol 2020 02;27(1):10072-10079

Tauranga Urology Research, Tauranga, New Zealand.

Introduction: To compare 3-year efficacy and safety after prostate resection with Aquablation therapy or transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms related to benign prostate hyperplasia (BPH).

Materials And Methods: One hundred and eighty-one patients assigned to either Aquablation therapy or TURP were followed for 3 years postoperatively. Patients and follow up assessors were blinded to treatment. Read More

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February 2020

Legends in Urology.

Can J Urol 2020 Feb;27(1):10068-10071

Professor of Urology, Chairman Emeritus, Department of Urology, University of Ulm, Germany.

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February 2020

Boosting Free Testosterone With OTC Natural Supplements: Be Careful What You Wish For.

Can J Urol 2020 Feb;27(1):10067

Thomas Jefferson University, Philadelphia, PA, USA.

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February 2020

Primary extragonadal yolk sac tumor originating from adrenal gland.

Can J Urol 2019 Dec;26(6):10064-10066

Department of Urology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Extragonadal germ cell tumors are germ cell tumors with no evidence of a primary tumor within the gonads, most often located in the mediastinum or retroperitoneum. We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. Read More

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December 2019

Endoscopic diagnosis of renal pseudoaneurysm following ureteroscopy.

Can J Urol 2019 Dec;26(6):10061-10063

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Renal pseudoaneurysm following ureteroscopy is a rare cause of hematuria usually diagnosed and treated with angiography and embolization. Here we present a case of a small pseudoaneurysm causing intermittent flank pain and gross hematuria associated with clot retention initially diagnosed during ureteroscopy and subsequently treated with a combined endourologic and endovascular approach. Read More

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December 2019

Alpha-dystroglycan staining pattern and mortality in patients undergoing radical prostatectomy with lymph node positive prostate cancer.

Can J Urol 2019 Dec;26(6):10054-10060

Department of Urology, University of Iowa Health Care, Iowa City, Iowa, USA.

Introduction: Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins involved in tissue mechanical stability and matrix organization. Initial work has demonstrated that alpha-DG expression is decreased in many types of adenocarcinoma, including prostate, and potentially associated with the development of metastatic disease. However, the consistency between prostate and lymph node alpha-DG staining has not been previously reported. Read More

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December 2019

Cost-effectiveness analysis of metformin with enzalutamide in the metastatic castrate-resistant prostate cancer setting.

Can J Urol 2019 Dec;26(6):10045-10053

Department of Radiation Oncology, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Enzalutamide (Enza) is an effective treatment for metastatic castrate-resistant prostate cancer (mCPRC). However, Enza is not cost-effective (CE) at willingness to pay (WTP) thresholds from $0-$125 000/quality adjusted life years (QALYs) and is therefore a strain on valuable health care dollars. Metformin (Met) is inexpensive (~$8. Read More

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December 2019

Satisfaction and surgical outcomes in patients undergoing penile prosthesis implantation for drug-refractory erectile dysfunction: mid-term results in a single center French cohort.

Can J Urol 2019 Dec;26(6):10039-10044

Sorbonne Universite, GRC no5, ONCOTYPE-URO, AP-HP, Urology, Hopital Pitie-Salpetriere, F-75013 Paris, France.

Introduction: To investigate the mid-term results of penile prosthesis (PP) implantation in patients with erectile dysfunction (ED) from a "real-life" historic cohort in a French academic center.

Materials And Methods: All patients receiving an inflatable PP between 2004 and 2014 in our institution were included in this study. ED was assessed preoperatively using the IEEF-5 questionnaire. Read More

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December 2019

Characterization of a learning curve for robotic cystectomy with intracorporeal urinary diversion at two institutions using the cumulative sum (CUSUM) method.

Can J Urol 2019 Dec;26(6):10033-10038

Division of Urology, Department of Surgery, University of Maryland Medical Center, Baltimore, Maryland, USA.

Introduction: Robotic cystectomy with intracorporeal urinary diversion (RCID) is a technically challenging procedure. It is understood that this approach has a learning curve; however, limited studies have characterized this learning curve. The cumulative sum (CUSUM) method plots the learning curve. Read More

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December 2019

An unusual presentation of testicular torsion in children: a single - centre retrospective study.

Can J Urol 2019 Dec;26(6):10026-10032

Department of Pediatric Surgery, University Hospital of Split, Split, Croatia.

Introduction: The aim of this study was to investigate demographic and clinical characteristics and outcomes of the treatments of the patients with an unusual presentation of the testicular torsion (TT) and to clarify their peculiarities.

Material And Methods: From January 1999 until December 2017, the case records of 149 patients who underwent surgery for TT were retrospectively reviewed. Out of that number, 25 patients were identified with unusual presentation of an acute scrotum (14 patients who presented with an abdominal pain only, and 11 who presented with testicular torsion in inguinal canal). Read More

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December 2019