117,774 results match your criteria Canadian Journal of Occupational Therapy [Journal]
Pediatr Phys Ther 2019 Jan;31(1):76-82
Division of Occupational Therapy and Physical Therapy (Ms McGuire and Drs Long and Bailes) and Division of Developmental and Behavioral Pediatrics (Dr Esbensen), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Purpose: This pilot study measured effects of an adapted dance program on motor abilities and participation in children with Down syndrome (DS) and explored caregivers' qualitative feedback regarding its benefits.
Methods: Children with DS participated in 20 weekly 1-hour adapted dance sessions. The Canadian Occupational Performance Measure (COPM) and Gross Motor Function Measure (GMFM) Dimensions D and E were administered before and after the program. Read More
J Occup Environ Med 2018 Dec 13. Epub 2018 Dec 13.
ExxonMobil Biomedical Sciences, Inc. (Schnatter), ExxonMobil Biomedical Sciences, Inc., 1545 U.S. Highway 22 East, Annandale, NJ 08801 (Wojcik), Palisades Research, Inc.(Jorgensen).
Objective: This study updates the mortality experience of over 25,000 workers in a large Canadian petroleum company through December 31, 2006.
Methods: Standardized Mortality Ratios were generated for all cause and specific cause mortality.
Results: All cause and all cancer mortality were favorable compared to the general Canadian population. Read More
J Neurophysiol 2018 Dec;120(6):3288
Neuromuscular Laboratory, School of Kinesiology, The University of Western Ontario , London, Ontario , Canada.
J Spinal Cord Med 2018 Dec 17:1-11. Epub 2018 Dec 17.
e Rick Hansen Institute , Vancouver , Canada.
Context: Persons with spinal cord injury (SCI) experience significant challenges when they access primary care and community services.
Design: A provincial summit was held to direct research, education, and innovation for primary and community care for SCI.
Setting: Toronto, Ontario, Canada. Read More
Can J Exp Psychol 2018 Dec 17. Epub 2018 Dec 17.
Department of Psychology.
In an immediate serial recall task, participants are presented with a list of items that they must subsequently report back in the original presentation order. Although immediate serial recall has long been taken as the standard short-term and working memory task, a growing body of literature has instead made use of immediate serial recognition. In immediate serial recognition, a list of items is presented and subsequently represented, either in the exact same order or with two adjacent items swapped. Read More
Early Interv Psychiatry 2018 Dec 16. Epub 2018 Dec 16.
ACCESS Open Minds (Pan-Canadian Youth Mental Health Services Research Network), Douglas Mental Health University Institute, Montréal, Québec, Canada.
Aim: Youth mental health is of paramount significance to society globally. Given early onset of mental disorders and the inadequate access to appropriate services, a meaningful service transformation, based on globally recognized principles, is necessary. The aim of this paper is to describe a national Canadian project designed to achieve transformation of mental health services and to evaluate the impact of such transformation on individual and system related outcomes. Read More
Int J Parasitol Parasites Wildl 2019 Apr 27;8:1-9. Epub 2018 Nov 27.
Direction de la gestion de la faune du Nord-du-Québec, Ministère des Forêts, de la Faune et des Parcs du Québec, 951 boul. Hamel, Chibougamau, Québec, G8P 2Z3, Canada.
In the present study, we report the first isolation of from North America and the second of at all. The parasite was isolated directly from the skin of a Canadian woodland caribou from the migratory ecotype. The animal belonged to the Leaf River Herd, in Northern Quebec, Canada. Read More
J Marriage Fam 2018 Oct 26;80(5):1244-1258. Epub 2018 Jul 26.
University of Texas at Austin, Population Research Center, 305 E 23rd Street, Stop G1800, Austin, TX 78712.
Objective: This study took a long view of childhood experiences that can contribute to the risk of teen pregnancy in the U.S. and Canada, two countries with different norms and policies surrounding family life and inequality. Read More
Sleep Med 2018 Nov 26. Epub 2018 Nov 26.
University of Alberta, Edmonton, AB, Canada.
Objectives/background: This paper outlines the current state of Canadian training, clinical services, research, and advocacy initiatives related to non-respiratory sleep disorders, with a specific focus on insomnia, the most common sleep problem in children.
Methods: Information for this narrative review was collected from peer-reviewed publications, web-resources, and personal communications and experiences.
Results: It is estimated that approximately one-third of Canadian children and youth present with insomnia, and that this is impacting their physical and mental health, as well as learning in school. Read More
Can J Diabetes 2018 Nov 2. Epub 2018 Nov 2.
Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada.
Objectives: To describe the clinical histories and management of adults with type 2 diabetes who were not reaching their target glycated hemoglobin (A1C) levels and to identify barriers to achieving therapeutic goals.
Methods: Practice assessment surveys and practice audits were completed by 88 primary care physicians (PCPs) in the Diabetes Mellitus Assessment of Clinical managemenT In ONtario (DM-ACTION) program and by 56 diabetes specialists in the Diabetes Mellitus IMproving PAtient Care in our communiTies (DM-IMPACT) program. The DM-ACTION audit analyzed data from 1,173 adults with A1C levels ≥7. Read More
J Sci Med Sport 2018 Nov 22. Epub 2018 Nov 22.
Human Performance Research and Development, Canadian Forces Morale and Welfare Services, Department of National Defence, Canada.
Objectives: The Canadian Army fitness objective is FORCE COMBAT™. This consists of a 5km march (35kg) between 50-60min, and the annual FORCE physical employment standard as a circuit without the usual 5min rest intervals (FORCE circuit) in full fighting order (25kg). The objective of this research was to determine the number of practice attempts required to establish reliability of FORCE COMBAT™. Read More
Am J Otolaryngol 2018 Nov 22. Epub 2018 Nov 22.
Division of Neurosurgery, QEII Halifax Infirmary Site, 3rd Floor, 1796 Summer Street, Halifax, NS B3H 3A7, Canada; Maritime Lateral Skull Base Clinic: Divisions of Neurosurgery, OtolaryngologyHead & Neck Surgery, Canada; Department of Radiation Oncology, Dalhousie University, QEII Health Sciences Centre, 3rd floor Dickson Building, 5820 University Avenue, Halifax, NS B3H 1Y9, Canada.
Patients with vestibular schwannomas (VS) typically present with hearing loss and tinnitus as well as variable cranial nerve dysfunctions. Surgical resection, stereotactic radiotherapy and/or conservative management employing serial magnetic resonance or computed tomography imaging serve as the main treatment options. Quality of life (QoL) may be impacted by the extent of tumour burden and exacerbated or relieved by treatment. Read More
Lancet Glob Health 2019 Jan;7(1):e68-e80
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Respiratory Division, McGill University, Montreal, QC, Canada.
Background: Indigenous peoples worldwide carry a disproportionate tuberculosis burden. There is an increasing awareness of the effect of social determinants and proximate determinants such as alcohol use, overcrowding, type 1 and type 2 diabetes, substance misuse, HIV, food insecurity and malnutrition, and smoking on the burden of tuberculosis. We aimed to understand the potential contribution of such determinants to tuberculosis in Indigenous peoples and to document steps taken to address them. Read More
Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.
Department of Neurosurgery, Division of Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, room G03.124, 3484 CX, Utrecht, The Netherlands.
Objective: Complications following pediatric cranioplasty after craniectomy with either autologous bone flaps or cranial implants are reported to be common, particularly bone flap resorption. However, only sparse data are available regarding cranioplasty strategies, complications, and outcomes. This manuscript describes a Canadian-Dutch multicenter pediatric cohort study with autografts and cranial implant cranioplasties following craniectomies for a variety of indications. Read More
Soc Sci Med 2018 Dec 1;221:19-26. Epub 2018 Dec 1.
Department of Sociology, McGill University, Room 712, Leacock Building, 855 Sherbrooke Street West, Montreal, QC, H3A 2T7, Canada. Electronic address:
The potential medical risks to egg donors, in addition to the concern over the commodification of life, has led to debates surrounding the ethics of paying donors. In Canada, payment for eggs is prohibited by law; however, what is considered payment is contentious and has yet to be defined. The lack of legislative clarity coupled with increased ethical concerns over paying a donor has shifted egg donation from a medically-controlled procedure to a legal and social endeavor involving multiple professionals. Read More
J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.
Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:
Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.
Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More
Bull Environ Contam Toxicol 2018 Dec 14. Epub 2018 Dec 14.
Mi'gmawe'l Tplu'taqnn Incorporated (MTI), 40 MicMac Road, Eel Ground, Miramichi, NB, E1V4B1, Canada.
The diets of Indigenous people rely on food and medicinal plants harvested directly from the land and there is increasing concern from Indigenous knowledge holders over changes to the appearance and flavor of wild harvested food and medicinal plants. We collected samples of muskrat root, considered an important medicinal plant, at 11 traditional collection locations to quantify contaminants of concern. There were no spatial or temporal trends apparent and the risk via consumption was found to be very low. Read More
BMJ Open 2018 Dec 14;8(12):e026954. Epub 2018 Dec 14.
Fielding School of Public Health, University of California, Los Angeles, California, USA.
Introduction: Deficiencies in childhood development is a major global issue and inequalities are large. The influence of environmental exposures on childhood development is currently insufficiently explored. This project will analyse the impact of various modifiable early life environmental exposures on different dimensions of childhood development. Read More
BMJ Open 2018 Dec 14;8(12):e025630. Epub 2018 Dec 14.
Departments of Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.
Introduction: Asthma exacerbations are a leading cause of paediatric hospitalisations. Corticosteroids are key in the treatment of asthma exacerbations. Most current corticosteroids treatment regimens for children admitted with asthma exacerbation consist of a 5-day course of prednisone or prednisolone. Read More
BMJ Open 2018 Dec 14;8(12):e023366. Epub 2018 Dec 14.
Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Introduction: Intravenous insertion (IVI) is a very common procedure in the emergency department (ED). IVI is often painful and stressful for both children and their families. Currently, distraction therapy is not used as a standard of care for IVI in North America. Read More
BMJ Open 2018 Dec 14;8(12):e019553. Epub 2018 Dec 14.
Department of Medicine, Division of Respirology, University of Toronto and Michael Garron Hospital, Michael Garron Hospital, Toronto, Ontario, Canada.
Objectives: Ensure early identification and timely management of patient deterioration as essential components of safe effective healthcare. Prompted by analyses of incident reports and deterioration events, a multicomponent organisational rescue from danger system was redesigned to decrease unexpected inpatient deterioration.
Design: Quality improvement before-after unblinded trial. Read More
Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.
Immunology Development, AbbVie, North Chicago, Illinois, USA.
Objective: To assess the efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in erosive hand osteoarthritis (HOA).
Methods: Patients with ≥1 erosive and ≥3 tender and/or swollen hand joints were randomised to placebo or lutikizumab 200 mg subcutaneously every 2 weeks for 24 weeks. The primary endpoint was change in Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subdomain score from baseline to 16 weeks. Read More
Can J Diabetes 2018 Oct 9. Epub 2018 Oct 9.
Indigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
Objectives: The Canadian Diabetes Risk Assessment Questionnaire (CANRISK) is a validated, evidence-based, self-administered tool to assess the risk for type 2 diabetes mellitus in multiethnic Canadian adults. Identifying individuals at high risk for type 2 diabetes allows early intervention that improves modifiable risk factors. This study examined the risk factors for type 2 diabetes in multiethnic urban youth in Edmonton, Alberta. Read More
Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada.
A variety of cellular stresses lead to global translation attenuation due to phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2), which decreases the availability of the eIF2-GTP-Met-tRNA ternary complex. However, a subset of mRNAs continues to be translated by non-canonical mechanisms under these conditions. In fact, although translation initiation of activating transcription factor 4 (ATF4) is normally repressed by an upstream open reading frame (uORF), a decreased availability of ternary complex leads to increased translation of the main ATF4-coding ORF. Read More
Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.
CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada. Electronic address:
Introduction: Accurate reference intervals (RIs) are essential for clinical interpretation of laboratory test results; however, major gaps exist in pediatric RIs. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established age- and sex-specific pediatric RIs on various analytical platforms. The current study expands the CALIPER database by establishing age- and sex-specific RIs for biochemical assays on Siemens ADVIA XPT/1800 and Dimension EXL Systems. Read More
Virus Res 2018 Dec 11. Epub 2018 Dec 11.
VIDO-InterVac, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Vaccinology & Immunotherapeutics, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada; Microbiology & Immunology, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada. Electronic address:
The U47 gene product, VP8, is a major tegument protein of BoHV-1. While VP8 is not essential for virus replication in cell culture, a U47-deleted virus exhibits a smaller tegument structure and is avirulent in cattle. To obtain pure VP8 protein for structural analysis, we expressed a N-terminally truncated version of VP8 in Eschericia coli. Read More
Anesthesiology 2019 Jan;130(1):41-54
From The North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Mercy Hospital, Pittsburgh, Pennsylvania (2000 through 2017; M.G.L., B.W.B.) Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida (2018; M.G.L.) Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan (T.T.K., M.T.V., S.K.) Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, Pennsylvania (2016 through 2018; B.W.B.) Department of Anesthesiology, School of Medicine (K.G.B., T.W.K., J.C.) School of Public Health (K.G.B.), University of Minnesota, Minneapolis, Minnesota Department of Anesthesiology, Children's Hospital of Pittsburgh (E.L.S.) Department of Anesthesiology (A.H.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Anesthesiology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York (J.L.) Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Canada (S.R.) Department of Anesthesiology and Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, Georgia (D.M.). Current positions: Dr. Larach is now at the Department of Anesthesiology, University of Florida, Gainesville, Florida. Dr. Sivak is now at the Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands Beaumont Health, Dearborn, Michigan Beaumont Health, Royal Oak, Michigan Beaumont Health, Farmington Hills, Michigan Beaumont Health, Grosse Pointe, Michigan Bronson Healthcare, Battle Creek, Michigan Bronson Healthcare, Kalamazoo, Michigan CHOC Children's Hospital, Orange, California Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Department of Anesthesiology, Columbia University Medical Center, New York, New York Henry Ford Health System, Detroit, Michigan Henry Ford Health System, West Bloomfield, Michigan Holland Hospital, Holland, Michigan Mercy Health, Muskegon, Michigan Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Langone Medical Center, New York, New York Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon St. Joseph Mercy, Ann Arbor, Michigan St. Joseph Mercy Oakland, Pontiac, Michigan St. Mary Mercy Hospital, Livonia, Michigan Sparrow Health System, Lansing, Michigan Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Anesthesiology, University of Colorado, Aurora, Colorado Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Department of Anesthesiology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, Tennessee Department of Anesthesiology, University of Utah, Salt Lake City, Utah Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont Department of Anesthesiology, University of Virginia, Charlottesville, Virginia Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee Department of Anesthesiology, Wake Forest Baptist Health, Winston-Salem, North Carolina Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri Department of Anesthesiology, Weill Cornell Medical College, New York, New York Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.
What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. Read More
J Clin Psychiatry 2018 Nov 20;79(6). Epub 2018 Nov 20.
Institute for Clinical Evaluative Sciences, London, Ontario, Canada.
Objective: Lithium is an effective treatment for mood disorders, but lithium level and renal monitoring every 3 months is recommended in older patients treated with lithium to prevent serious adverse events. This study examined lithium monitoring practices in a large geriatric cohort.
Methods: This population-based cohort study (N = 11,006) used linked health care administrative databases. Read More
Transfusion 2018 Dec 14. Epub 2018 Dec 14.
Department of Pathology and the Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA.
Background: Wrong blood in tube (WBIT) errors are a preventable cause of ABO-mismatched RBC transfusions. Electronic patient identification systems (e.g. Read More
Gerodontology 2018 Dec 14. Epub 2018 Dec 14.
Cooperative Research Centre for Oral Health Science Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.
Aims: The aim of this study was to explain through the life-course and life-span perspectives of developmental regulation theory the controls on dental experiences and beliefs throughout the lives of older people in Guangzhou and Hong Kong.
Background: Dental diseases and disabilities among older people are serious public health concerns in China.
Methods: A facilitator conducted eight focus groups, three in Hong Kong and five in Guangzhou, involving a total of 51 participants. Read More
Magn Reson Med 2018 Dec 13. Epub 2018 Dec 13.
Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.
Purpose: To develop a correction method for the effects of the magnetic susceptibility of fat (χ ) on the calculation of venous oxygen saturation (SvO ).
Theory: The magnetic field shifts associated with the magnetic susceptibility of deoxyhemoglobin can be used to estimate SvO , a measure of oxygen extraction and metabolism. However, the distinct magnetic susceptibility of fat surrounding targeted veins will give rise to magnetic field perturbations that will extend into the vein and surrounding tissues, potentially confounding the calculation of SvO . Read More
Community Dent Oral Epidemiol 2018 Dec 13. Epub 2018 Dec 13.
Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.
Objectives: To explore the sociocultural context in which patients and dentists in urban and rural communities in Southern Brazil interpret dental problems.
Method: Beliefs and experiences related to dental problems were explored in eight focus groups involving a total of 41 older patients, and in direct interviews with two dentists and two dental assistants. The interactions were audio recorded and transcribed for thematic analysis. Read More
Chem Rec 2018 Dec 13. Epub 2018 Dec 13.
Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada, K7K 7B4.
Organic photovoltaic cells commonly use an active layer with a polycrystalline bulk heterojunction. However, for simplifying the fabrication process, it may be worthwhile to use an amorphous active layer to lessen the burden on processing to achieve optimal performance. While polymers can adopt amorphous phases, molecular glasses, small molecules that can readily form glassy phases and do not crystallize over time, offer an appealing alternative, being monodisperse species. Read More
J Cell Mol Med 2018 Dec 13. Epub 2018 Dec 13.
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
Aberrant regulation of programmed cell death (PCD) has been tied to an array of human pathologies ranging from cancers to autoimmune disorders to diverse forms of neurodegeneration. Pharmacologic modulation of PCD signalling is therefore of central interest to a number of clinical and biomedical applications. A key component of PCD signalling involves the modulation of pro- and anti-apoptotic Bcl-2 family members. Read More
Am J Ind Med 2018 Dec 13. Epub 2018 Dec 13.
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Objective: Federal Region X is an administrative region in the northwestern United States comprised of the states of Alaska (AK), Idaho (ID), Oregon (OR), and Washington (WA). Quantifying the number of workers in this region exposed to harmful circumstances in the workplace, and projected changes over time will help to inform priorities for occupational health training, risk reduction, and research.
Methods: State data for WA, ID, OR, and AK were used to estimate number of workers by occupation, in 2014 and 2024. Read More
Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.
Chapel Hill: Department of Medicine, Division of Cardiology, University of North Carolina, 160 Dental Circle CB#7075, Chapel Hill, NC 27599, USA.
Background: Catheter ablation improves symptoms and quality of life in patients with atrial fibrillation (AF); however, despite its benefit, women are less likely than men to undergo catheter ablation. Women with AF have been described to have more frequent and severe symptoms with a lower quality of life than men, and it is therefore unclear why women are less likely to undergo catheter ablation. We prospectively characterized gender differences in AF symptoms among men and women undergoing ablation at UNC using questionnaire data. Read More
Health Soc Care Community 2018 Dec 12. Epub 2018 Dec 12.
Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Stigma is a widely recognised public health issue. Many people with neurological disease and their families experience stigmatisation, adding to their burden of illness. Rural populations are typically small, lack anonymity, and often have a higher proportion of older adults with inadequate access to specialised services and resources. Read More
Br J Clin Psychol 2018 Dec 12. Epub 2018 Dec 12.
Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Quebec, Canada.
Objective: The potential causal and maintaining role of vulnerable self-themes and beliefs about the self in obsessive-compulsive disorder (OCD) have received increasing attention from cognitive-behavioural theorists. This interest was translated into the development of a self-report measurement of the feared self (the fear of who one might be or become), a construct theoretically and empirically pertinent to unwanted thoughts and impulses in OCD (i.e. Read More
Psych J 2018 Dec 12. Epub 2018 Dec 12.
Faculty of Psychology, Beijing Normal University, Beijing, China.
The current study reports on a cross-cultural validation of the recently developed Resiliency Scale for Young Adults (RSYA) with two samples consisting of 617 Canadian university students and 651 Chinese university students. Confirmatory factor analysis, tests of cultural invariance, and correlations with relevant individual difference variables were conducted as tests of validity. In the Chinese sample, confirmatory factor analysis supported the factor structure of the RSYA and internal consistency reliabilities for the three factors and 10 facets were good-to-excellent. Read More
Curr Protoc Stem Cell Biol 2018 Dec 12:e75. Epub 2018 Dec 12.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
We have established an in vitro model of the human congenital heart defect (CHD)-associated mutation NKX2.5 R141C. We describe the use of the hanging drop method to differentiate Nkx2. Read More
Wiley Interdiscip Rev RNA 2018 Dec 11:e1521. Epub 2018 Dec 11.
Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland.
The double-stranded RNA-binding protein (dsRBP) family controls RNA editing, stability, and function in all eukaryotes. The central feature of this family is the recognition of a generic RNA duplex using highly conserved double-stranded RNA-binding domain (dsRBD) that recognizes the characteristic distance between the minor grooves created by the RNA helix. Variations on this theme that confer species and functional specificities have been reported but most dsRBPs retain their capacity to bind generic dsRNA. Read More
Early Interv Psychiatry 2018 Dec 11. Epub 2018 Dec 11.
Douglas Mental Health University Institute, Montreal, Canada.
Aim: This paper aims to advance our understanding of the experience of participating in peer support groups for family members of persons with psychosis and to expand the scant body of literature on peer support in the context of early intervention services for psychosis. Such an examination is relevant because the implementation and uptake of family-focused interventions remain inconsistent in early intervention services, despite their proven benefits.
Methods: To enable family caregivers to support one another, a family peer support project was initiated at an early intervention service for psychosis in Montreal, Canada. Read More
Pharmacoepidemiol Drug Saf 2018 Dec 12. Epub 2018 Dec 12.
Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada.
Purpose: Opioid use and associated mortality and morbidity have substantially increased in Canada, which recent interventions have aimed to reduce. Tramadol is an atypical prescription-only (but unscheduled under Canada's narcotics law) opioid analgesic and not subject to controls for other (eg, strong) opioids. Given experiences in different jurisdictions, tramadol may have been increasingly dispensed as a "substitute" drug during a period with increasingly restrictive controls for other (scheduled) opioids. Read More
Physiol Plant 2018 Dec 11. Epub 2018 Dec 11.
School of Science and the Environment, Grenfell Campus, Memorial University of Newfoundland, Corner Brook, A2H 5G4, Canada.
The literature is replete with information describing the composition of the root lipidome in several plant species grown under various environmental conditions. However, it is unknown to what extent the root membrane lipidome vary between silage-corn genotypes, and how such variation could influence agronomic performances during field cultivation in cool climate. To address this issue, the root membrane lipidome and agronomic performance were assessed for five silage-corn genotypes (Fusion-RR, Yukon-R, A4177G3-RIB, DKC23-17RIB, DKC26-28RIB) cultivated under cool climatic conditions. Read More
Br J Educ Psychol 2018 Dec 11. Epub 2018 Dec 11.
Laboratory for Cognitive Investigations and Behavioral Genetics, Department of Psychology, Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Oblast, Russia.
Background: The number line task assesses the ability to estimate numerical magnitudes. People vary greatly in this ability, and this variability has been previously associated with mathematical skills. However, the sources of individual differences in number line estimation and its association with mathematics are not fully understood. Read More
Physiol Rep 2018 Dec;6(23):e13937
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Inflammation contributes to obesity-related hyperinsulinemia and insulin resistance, which often precede type 2 diabetes. Inflammation is one way that obesity can promote insulin resistance. It is not clear if the extent of obesity, hyperinsulinemia, or hyperglycemia, underpins changes in cellular immunity during diet-induced obesity. Read More
Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.
Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton.
Purpose Of Review: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.
Recent Findings: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Read More
BMC Med Educ 2018 Dec 14;18(1):307. Epub 2018 Dec 14.
Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Background: Including content on Indigenous health in medical school curricula has become a widely-acknowledged prerequisite to reducing the health disparities experienced by Indigenous peoples in Canada. However, little is known about what levels of awareness and interest medical students have about Indigenous peoples when they enter medical school. Additionally, it is unclear whether current Indigenous health curricula ultimately improve students' beliefs and behaviours. Read More
Phys Rev Lett 2018 Nov;121(22):221301
Department of Physics, California Institute of Technology, Pasadena, California 91125, USA.
We present results from an analysis of all data taken by the bicep2/Keck CMB polarization experiments up to and including the 2015 observing season. This includes the first Keck Array observations at 220 GHz and additional observations at 95 and 150 GHz. The Q and U maps reach depths of 5. Read More