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    1854 results match your criteria Canadian Journal of Gastroenterology[Journal]

    1 OF 38

    Evaluation of funding gastroenterology research in Canada illustrates the beneficial role of partnerships.
    Can J Gastroenterol 2013 Dec;27(12):717-20
    Background: Funders of health research in Canada seek to determine how their funding programs impact research capacity and knowledge creation.

    Objective: To evaluate the impact of a focused grants and award program that was cofunded by the Canadian Institutes of Health Research Institute of Nutrition, Metabolism and Diabetes, and the Canadian Association of Gastroenterology; and to measure the impact of the Program on the career paths of funded researchers and assess the outcomes of research supported through the Program.

    Methods: A survey of the recipients of grants and awards from 2000 to 2008 was conducted in 2012. Read More

    Use of fecal occult blood test in hospitalized patients: survey of physicians practicing in a large central Canadian health region and Canadian gastroenterologists.
    Can J Gastroenterol 2013 Dec;27(12):711-6
    Background: Although the fecal occult blood test (FOBT) was developed for colorectal cancer screening in the outpatient setting, it continues to be used among hospitalized patients. No previous study has evaluated the knowledge, beliefs and attitudes of practicing physicians on the use of FOBT among hospitalized patients and compared practices among physicians with different medical specialty training.

    Objective: To survey physicians in the Winnipeg Regional Health Authority (WRHA) and Canadian gastroenterologists (GIs) on the use of FOBT in hospitals. Read More

    Treatment of chronic hepatitis C in a Canadian Aboriginal population: results from the PRAIRIE study.
    Can J Gastroenterol 2013 Dec;27(12):707-10
    Background: The Aboriginal population of Canada is at increased risk of exposure to the hepatitis C virus (HCV). Previous data indicate that spontaneous clearance of HCV occurs more often in Aboriginals than Caucasians. Whether this enhanced response extends to antiviral therapy for chronic HCV remains to be determined. Read More

    A randomized controlled trial comparing sequential with triple therapy for Helicobacter pylori in an Aboriginal community in the Canadian North.
    Can J Gastroenterol 2013 Dec;27(12):701-6
    Background: Helicobacter pylori infection occurs more frequently in Arctic Aboriginal settings than elsewhere in North America and Europe. Research aimed at reducing health risks from H pylori infection has been conducted in the Aboriginal community of Aklavik, Northwest Territories.

    Objective: To compare the effectiveness of the Canadian standard therapy with an alternative therapy for eliminating H pylori infection in Aklavik. Read More

    Improving the quality of colonoscopy bowel preparation using an educational video.
    Can J Gastroenterol 2013 Dec;27(12):696-700
    Colonoscopy is the preferred modality for colon cancer screening. A successful colonoscopy requires proper bowel preparation. Adequate bowel preparation continues to remain a limiting factor. Read More

    Endoscopic submucosal dissection in the colorectum: Feasibility in the Canadian setting.
    Can J Gastroenterol 2013 Dec;27(12):689-93
    Endoscopic submucosal dissection is a minimally invasive endoscopic technique for the removal of gastrointestinal tumours that is increasingly being used for colonic neoplasms to spare resection of colon in selected patients. Colonic endoscopic submucosal dissection is technically challenging and was initially pioneered in Japan but increasingly used in selected western centres. Its use in Canada is currently limited, and the authors review the challenges and opportunities, in addition to the unique training infrastructure required to practice the procedure under supervision. Read More

    Yield and cost of performing screening tests for constipation in children.
    Can J Gastroenterol 2013 Dec 13;27(12):e35-8. Epub 2013 Nov 13.
    Background: Chronic constipation is one of the most common reasons for pediatric outpatient visits. Clinical guidelines recommend that the work-up for chronic refractory constipation include thyroid function tests, celiac serology, and measurement of calcium and lead levels. Data to justify routine screening of constipated children using these laboratory tests are lacking. Read More

    Percutaneous liver biopsy practice patterns among Canadian hepatologists.
    Can J Gastroenterol 2013 Nov;27(11):e31-4
    Background: Percutaneous liver biopsy (PLB) is the standard procedure to obtain histological samples essential for the management of various liver diseases. While safe, many hepatologists no longer perform their own PLBs; the reasons for this practice shift are unknown.

    Objective: To describe the attitudes, practice patterns and barriers to PLB among hepatologists in Canada. Read More

    Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment.
    Can J Gastroenterol 2013 Nov;27(11):653-9
    Background: Bile acid malabsorption (BAM) is a common but frequently under-recognized cause of chronic diarrhea, with an estimated prevalence of 4% to 5%.

    Methods: The published literature for the period 1965 to 2012 was examined for articles regarding the pathophysiology and treatment of BAM to provide an overview of the management of BAM in gastroenterology practice.

    Results: BAM is classified as type 1 (secondary to ileal dysfunction), type 2 (idiopathic) or type 3 (secondary to gastrointestinal disorders not associated with ileal dysfunction). Read More

    Employment prospects and trends for gastroenterology trainees in Canada: a nationwide survey.
    Can J Gastroenterol 2013 Nov;27(11):647-52
    Background: Many gastroenterology (GI) trainees face a variety of barriers to stable employment and are finding it increasingly difficult to secure employment in their chosen field.

    Objective: To elucidate factors that contribute to the burden of unemployment and underemployment, and to examine solutions that may remedy this growing problem in the field of GI.

    Methods: A nationwide survey of current, incoming and recently graduated individuals of GI training programs in Canada was conducted. Read More

    The Second Canadian Symposium on hepatitis C virus: a call to action.
    Can J Gastroenterol 2013 Nov;27(11):627-32
    In Canada, hepatitis C virus (HCV) infection results in considerable morbidity, mortality and health-related costs. Within the next three to 10 years, it is expected that tolerable, short-duration (12 to 24 weeks) therapies capable of curing >90% of those who undergo treatment will be approved. Given that most of those already infected are aging and at risk for progressive liver disease, building research-based interdisciplinary prevention, care and treatment capacity is an urgent priority. Read More

    Gastric biopsies: the gap between evidence-based medicine and daily practice in the management of gastric Helicobacter pylori infection.
    Can J Gastroenterol 2013 Oct;27(10):e25-30
    Background: Many consider histology to be the gold standard for Helicobacter pylori detection. Because the number and distribution of H pylori organisms vary, particularly in patients taking proton pump inhibitors (PPIs), the American Gastroenterological Association recommends discontinuing PPIs two weeks before endoscopy, and taking biopsies from both the body and antrum.

    Objective: To assess the influence of clinical practice on the histopathological detection of H pylori infection. Read More

    A pilot study examining the relationship among Crohn disease activity, glucagon-like peptide-2 signalling and intestinal function in pediatric patients.
    Can J Gastroenterol 2013 Oct;27(10):587-92
    Unlabelled: BACKGROUND⁄

    Objectives: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release. Read More

    Capnography improves detection of apnea during procedural sedation for percutaneous transhepatic cholangiodrainage.
    Can J Gastroenterol 2013 Oct;27(10):582-6
    Background: Capnography provides noninvasive monitoring of ventilation and can enable early recognition of altered respiration patterns and apnea.

    Objective: To compare the detection of apnea and the prediction of oxygen desaturation and hypoxemia using capnography versus clinical surveillance during procedural sedation for percutaneous transhepatic cholangiodrainage (PTCD).

    Methods: Twenty consecutive patients scheduled for PTCD were included in the study. Read More

    Antidepressant prophylaxis reduces depression risk but does not improve sustained virological response in hepatitis C interferon recipients without depression at baseline: a systematic review and meta-analysis.
    Can J Gastroenterol 2013 Oct;27(10):575-81
    Background: Depression complicates interferon-based hepatitis C virus (HCV) antiviral therapy in 10% to 40% of cases, and diminishes patient well-being and ability to complete a full course of therapy. As a consequence, the likelihood of achieving a sustained virological response (SVR [ie, permanent viral eradication]) is reduced.

    Objective: To systematically review the evidence of whether pre-emptive antidepressant prophylaxis started before HCV antiviral initiation is beneficial. Read More

    Minimal hepatic encephalopathy.
    Can J Gastroenterol 2013 Oct;27(10):572-4
    Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy and can affect up to 80% of cirrhotic patients. By definition, it has no obvious clinical manifestation and is characterized by neurocognitive impairment in attention, vigilance and integrative function. Although often not considered to be clinically relevant and, therefore, not diagnosed or treated, MHE has been shown to affect daily functioning, quality of life, driving and overall mortality. Read More

    Challenges in the diagnosis and management of autoimmune hepatitis.
    Can J Gastroenterol 2013 Sep;27(9):531-9
    Background: Autoimmune hepatitis has diverse clinical phenotypes and outcomes that challenge current diagnostic criteria and management algorithms.

    Objectives: To highlight the major difficulties in diagnosis and management, describe the efforts to ease them and encourage further progress in problem solving.

    Methods: The MEDLINE database was reviewed for published experiences from 1984 to 2013. Read More

    Immunoglobulin G4-related pancreatic and biliary diseases.
    Can J Gastroenterol 2013 Sep;27(9):523-30
    Background: Autoimmune pancreatitis and autoimmune cholangitis are new clinical entities that are now recognized as the pancreatico-biliary manifestations of immunoglobulin (Ig) G4-related disease.

    Objective: To summarize important clinical aspects of IgG4-related pancreatic and biliary diseases, and to review the role of IgG4 in the diagnosis of autoimmune pancreatitis (AIP) and autoimmune cholangitis (AIC).

    Methods: A narrative review was performed using the PubMed database and the following keywords: "IgG4", "IgG4 related disease", "autoimmune pancreatitis", "sclerosing cholangitis" and "autoimmune cholangitis". Read More

    General anesthetic versus light sedation: effect on pediatric endoscopy wait times.
    Can J Gastroenterol 2013 Sep;27(9):519-22
    Background: Wait times are an important measure of health care system effectiveness. There are no studies describing wait times in pediatric gastroenterology for either outpatient visits or endoscopy. Pediatric endoscopy is performed under light sedation or general anesthesia. Read More

    Biliary drainage method and temporal trends in patients admitted with cholangitis: a national audit.
    Can J Gastroenterol 2013 Sep;27(9):513-8
    Background: In patients presenting with ascending cholangitis, better outcomes are reported in those undergoing endoscopic retrograde cholangiopancreatography (ERCP) compared with surgical drainage.

    Objective: To identify factors associated with the type of intervention, and to examine temporal trends in the treatment of ascending cholangitis.

    Methods: Data were extracted from the Nationwide Inpatient Sample. Read More

    A simple method to improve adenoma detection rate during colonoscopy: altering patient position.
    Can J Gastroenterol 2013 Sep;27(9):509-12
    Background: Colonoscopy is currently considered to be the gold standard method for detecting and removing adenomatous polyps. However, tandem colonoscopy studies reveal a pooled polyp miss rate of 22%.

    Objective: A prospective randomized trial was conducted to assess whether alteration of patient position during colonoscopy withdrawal increases the adenoma detection rate (ADR). Read More

    Do we eradicate Helicobacter pylori in hospitalized patients with peptic ulcer disease?
    Can J Gastroenterol 2013 Nov 13;27(11):636-8. Epub 2013 Sep 13.
    Background: Helicobacter pylori infection is the most common chronic infection in humans. It is a major contributor to the cause of duodenal and gastric ulcers worldwide. Its eradication has been shown to reduce rates of H pylori-related ulcers as well as other complications such as gastric cancer. Read More

    Liver transplantation for alcoholic liver disease among Canadian transplant centres: a national study.
    Can J Gastroenterol 2013 Nov 13;27(11):643-6. Epub 2013 Sep 13.
    Unlabelled: BACKGROUND⁄

    Objective: Alcoholic liver disease (ALD) is a controversial yet established indication for liver transplantation (LT), and there is emerging evidence supporting a survival benefit in selected patients with severe acute alcoholic hepatitis. The aim of the present survey was to describe policies among Canadian transplant centres for patients with ALD.

    Methods: A survey was distributed to the medical directors of all seven liver transplant centres in Canada. Read More

    Hepatitis C as a prognostic indicator among noncirrhotic patients hospitalized with alcoholic hepatitis.
    Can J Gastroenterol 2013 Nov 13;27(11):639-42. Epub 2013 Sep 13.
    Objective: A nationwide analysis of alcoholic hepatitis (AH) admissions was conducted to determine the impact of hepatitis C virus (HCV) infection on short-term survival and hospital resource utilization.

    Methods: Using the Nationwide Inpatient Sample, noncirrhotic patients admitted with AH throughout the United States between 1998 and 2006 were identified with diagnostic codes from the International Classification of Diseases, Ninth Revision. The in-hospital mortality rate (primary end point) of AH patients with and without co-existent HCV infection was determined. Read More

    Improving access in gastroenterology: the single point of entry model for referrals.
    Can J Gastroenterol 2013 Nov 13;27(11):633-5. Epub 2013 Sep 13.
    In 2005, a group of academic gastroenterologists in Calgary (Alberta) adopted a centralized referral intake system known as central triage. This system provided a single point of entry model (SEM) for referrals rather than the traditional system of individual practitioners managing their own referrals and queues. The goal of central triage was to improve wait times and referral management. Read More

    Magnetic resonance imaging of the perineum in pediatric patients with inflammatory bowel disease.
    Can J Gastroenterol 2013 Aug;27(8):476-80
    Division of Gastroenterology, Hepatology and Nutrition, BC Children's Hospital, University of British Columbia, Vancouver, Canada.
    Magnetic resonance imaging (MRI) has profoundly changed and improved the investigation of abdominal and pelvic inflammatory bowel disease (IBD) in pediatrics. Using an imaging modality without ionizing radiation is of particular advantage because the pediatric IBD population is young and often requires repeat evaluation. MRI of the pelvis has become the imaging gold standard for detecting and monitoring perianal disease while bowel-directed imaging techniques (eg, enterography, enteroclysis and colonography) can accurately evaluate bowel inflammation in IBD. Read More

    Diagnostic value of stool DNA testing for multiple markers of colorectal cancer and advanced adenoma: a meta-analysis.
    Can J Gastroenterol 2013 Aug;27(8):467-75
    Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
    Background And Objectives: The diagnostic value of stool DNA (sDNA) testing for colorectal neoplasms remains controversial. To compensate for the lack of large-scale unbiased population studies, a meta-analysis was performed to evaluate the diagnostic value of sDNA testing for multiple markers of colorectal cancer (CRC) and advanced adenoma.

    Methods: The PubMed, Science Direct, Biosis Review, Cochrane Library and Embase databases were systematically searched in January 2012 without time restriction. Read More

    Patient and parent satisfaction with a dietitian- and nurse- led celiac disease clinic for children at the Stollery Children's Hospital, Edmonton, Alberta.
    Can J Gastroenterol 2013 Aug;27(8):463-6
    Department of Pediatrics, University of Alberta, Edmonton, Canada.
    Objective: To assess patient and parent satisfaction with a primarily nurse- and dietitian-led celiac disease clinic in a tertiary pediatric centre.

    Methods: An online survey was sent to families and patients attending the Stollery Children's Hospital's Multidisciplinary Pediatric Celiac Clinic (Edmonton, Alberta) since 2007. The survey focused on clinic attendance, satisfaction with clinic structure, processes, and education and preference for alternatives to the current process. Read More

    Transnasal endoscopic evaluation of swallowing: a bedside technique to evaluate ability to swallow pureed diets in elderly patients with dysphagia.
    Can J Gastroenterol 2013 Aug;27(8):459-62
    Department of Rehabilitation, Showa Inan General Hospital, Komagane, Japan.
    Background: Endoscopic evaluation of swallowing (EES) is not commonly used by gastroenterologists to evaluate swallowing in patients with dysphagia.

    Objective: To use transnasal endoscopy to identify factors predicting successful or failed swallowing of pureed foods in elderly patients with dysphagia.

    Methods: EES of pureed foods was performed by a gastroenterologist using a small-calibre transnasal endoscope. Read More

    Predictors of early rebleeding after endoscopic therapy in patients with nonvariceal upper gastrointestinal bleeding secondary to high-risk lesions.
    Can J Gastroenterol 2013 Aug;27(8):454-8
    Department of Medicine, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
    Background: In an era of increasingly shortened admissions, data regarding predictors of early rebleeding among patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) exhibiting high-risk stigmata (HRS) having undergone endoscopic hemostasis are lacking.

    Objectives: To determine predictors of early rebleeding, defined as rebleeding before completion of recommended 72 h intravenous proton pump inhibitor infusion postendoscopic hemostasis.

    Methods: Data from a national registry of patients with upper gastrointestinal bleeding (the REASON registry) were accessed. Read More

    Clinical features and symptom recovery on a gluten-free diet in Canadian adults with celiac disease.
    Can J Gastroenterol 2013 Aug;27(8):449-53
    Faculty of Medicine, University of Ottawa, Ontario, Canada.
    Background: Celiac disease can present with mild or nongastrointestinal symptoms, and may escape timely recognition. The treatment of celiac disease involves a gluten-free diet, which is complex and challenging.

    Objective: To evaluate clinical features and symptom recovery on a gluten-free diet in a Canadian adult celiac population. Read More

    Diagnosis and management of the overlap syndromes of autoimmune hepatitis.
    Can J Gastroenterol 2013 Jul;27(7):417-23
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
    Background: Autoimmune hepatitis may have cholestatic features that are outside the classical phenotype and that resemble findings in other immune-mediated liver diseases. These cholestatic phenotypes have been designated 'overlap syndromes'.

    Objectives: To recognize the overlap syndromes in adults and manage them appropriately. Read More

    Pretreatment resistance to hepatitis C virus protease inhibitors boceprevir/telaprevir in hepatitis C virus subgenotype 1a-infected patients from Manitoba.
    Can J Gastroenterol 2013 Jul;27(7):414-6
    Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
    Background: Traditional therapy with pegylated interferon and ribavirin combined with the new protease inhibitors boceprevir or telaprevir has demonstrated improved outcomes in hepatitis C virus (HCV)-infected patients. Prevalence data regarding pre-existing drug-resistant variants to these two new virus inhibitors in the Canadian population are not available.

    Objective: To detect pre-existing mutations conferring resistance to boceprevir and⁄or telaprevir in Canadian patients infected with HCV genotype 1a. Read More

    Natural history and long-term outcomes of patients treated for early stage colorectal cancer.
    Can J Gastroenterol 2013 Jul;27(7):409-13
    Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada.
    Background: The long-term natural history of early stage colon cancer and the outcome of long-term colonoscopic surveillance in routine specialist clinical practice after removal of the incident cancers have not been fully defined. In the present long-term evaluation up to 25 years, metachronous neoplasia, including both advanced adenomas and carcinomas, was defined.

    Methods: All early stage colorectal cancer patients evaluated consecutively from a single clinical practice underwent follow-up colonoscopic evaluations after removal of the incident cancer and clearing of neoplastic disease. Read More

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