117,636 results match your criteria Canadian Journal of Experimental Psychology [Journal]


Evaluation of the Measuring and Improving Quality in Palliative Care Survey.

J Oncol Pract 2018 Dec;14(12):e834-e843

Johns Hopkins Bloomberg School of Public Health; Johns Hopkins School of Medicine, Baltimore, MD; University of Cincinnati College of Medicine, Cincinnati, OH; Duke Cancer Institute and Duke Fuqua School of Business, Duke University, Durham, NC; Veterans Affairs Greater Los Angeles Health System, University of California, Los Angeles, Los Angeles; Stanford School of Medicine, Stanford, CA; Temmy Latner Centre for Palliative Care, Sinai Health System; University of Toronto; and Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Purpose:: To evaluate the reliability, content validity, and variation among sites of a survey to assess facilitators and barriers to quality measurement and improvement in palliative care programs.

Methods:: We surveyed a sample of diverse US and Canadian palliative care programs and conducted postcompletion discussion groups. The survey included constructs addressing educational support and training, communication, teamwork, leadership, and prioritization for quality measurement and improvement. Read More

View Article
December 2018

Methicillin-resistant Staphylococcus aureus in urban Norway rat (Rattus norvegicus) populations: Epidemiology and the impacts of kill-trapping.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.

Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More

View Article
December 2018

A Comparison of U.S. and Canadian Osteoporosis Screening and Treatment Strategies in Postmenopausal Women.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset). Read More

View Article
December 2018

Commentary on Otten et al. (2019): moderators and person-environment interactions in developmental cascade models.

Addiction 2018 Dec 9. Epub 2018 Dec 9.

Department of Psychiatry and Addiction, Université de Montréal, Montréal, QC, Canada.

View Article
December 2018

Pain in patients with newly diagnosed or relapsed acute leukemia.

Support Care Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., 16-712, Toronto, Ontario, M5G 2M9, Canada.

Purpose: Acute leukemia (AL) is associated with substantial morbidity and mortality. We assessed the prevalence and correlates of pain in patients with newly diagnosed or relapsed AL.

Methods: Patients with newly diagnosed or relapsed AL admitted to a comprehensive cancer center completed the Memorial Symptom Assessment Scale (MSAS), which assesses prevalence, severity, and distress associated with pain and other symptoms. Read More

View Article
December 2018

The Final Size of a Serious Epidemic.

Authors:
Fred Brauer

Bull Math Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.

In an epidemic of a serious disease, there is likely to be behavioral response that decreases the epidemic size considerably, and taking this into account may lead to estimates of the final epidemic size that are much smaller and more realistic than estimates that do not take this into account. Read More

View Article
December 2018

Preparing to migrate: expression of androgen signaling molecules and insulin-like growth factor-1 in skeletal muscles of Gambel's white-crowned sparrows.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurobiology Physiology Behavior, University of California, Davis, USA.

Migratory birds, including Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii), exhibit profound modifications of skeletal muscles prior to migration, notably hypertrophy of the pectoralis muscle required for powered flight. Muscle growth may be influenced by anabolic effects of androgens; however, prior to spring departure, circulating androgens are low in sparrows. A seasonal increase in local androgen signaling may occur within muscle to promote remodeling. Read More

View Article
December 2018

ARENA: Inter-modality affine registration using evolutionary strategy.

Int J Comput Assist Radiol Surg 2018 Dec 10. Epub 2018 Dec 10.

PERFORM Centre, Concordia University, Montreal, Canada.

Purpose: Image fusion of different imaging modalities renders valuable information to clinicians. In this paper, we proposed an automatic multimodal registration method to register intra-operative ultrasound images (US) to preoperative magnetic resonance images (MRI) in the context of image-guided neurosurgery.

Methods: We employed refined correlation ratio as a similarity metric for our intensity-based image registration method. Read More

View Article
December 2018

External validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy.

Eur J Nucl Med Mol Imaging 2018 Dec 7. Epub 2018 Dec 7.

Radiation Oncology Department, University Hospital, Brest, France.

Purpose: The aim of this study was to validate previously developed radiomics models relying on just two radiomics features from F-fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) images for prediction of disease free survival (DFS) and locoregional control (LRC) in locally advanced cervical cancer (LACC).

Methods: Patients with LACC receiving chemoradiotherapy were enrolled in two French and one Canadian center. Pre-treatment imaging was performed for each patient. Read More

View Article
December 2018

The relationship between aerobic fitness and low-flow-mediated constriction in older adults.

Eur J Appl Physiol 2018 Dec 10. Epub 2018 Dec 10.

Autonomic Cardiovascular Control and Exercise Laboratory, School of Health and Human Performance, Division of Kinesiology, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.

Purpose: Aerobic fitness is directly related to favorable vasodilatory (i.e., flow-mediated dilation; FMD) and vasoconstrictor functions (i. Read More

View Article
December 2018

IBDoc Canadian User Performance Evaluation.

Inflamm Bowel Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Gastroenterology, University of British Columbia, Vancouver, Canada.

Background: Fecal calprotectin (FC) is a stool biomarker that has been shown to be sensitive and specific for mucosal inflammation in patients with inflammatory bowel disease (IBD). The test is limited by the requirement for patients to collect and return stool samples. A home-based FC test may improve test adherence. Read More

View Article
December 2018

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015.

J Pediatric Infect Dis Soc 2018 Dec 8. Epub 2018 Dec 8.

Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, Canada.

Background: Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation in some countries for vaccination against pertussis during pregnancy. Having data on the burden of pediatric pertussis in a large population over time is important for establishing the true burden of disease in the acellular pertussis (aP) vaccine era. Here, we describe age-specific epidemiology and morbidity and mortality rates in children hospitalized with pertussis over 17 years across Canada in the aP vaccine era. Read More

View Article
December 2018

Automatic and semi-automatic assignment and fitting of spectra with PGOPHER.

Phys Chem Chem Phys 2018 Dec 11. Epub 2018 Dec 11.

Canadian Light Source, University of Saskatchewan, Canada.

Two new tools for computer assisted assignment of rotational spectra with the PGOPHER program are presented, aimed particularly at spectra where many individual lines are resolved. The first tool tries many different assignments, presenting a small number for possible refinement and a preliminary version of this has already been presented. The second tool, the nearest lines plot (a new style of residual plot) provides a clear indication as to whether a trial calculation is plausible, and allows rapid assignment of sets of related lines. Read More

View Article
December 2018

Effect of β-lactam antibiotic resistance gene expression on the radio-resistance profile of O157:H7.

Heliyon 2018 Dec 1;4(12):e00999. Epub 2018 Dec 1.

Research Laboratories in Sciences Applied to Food, Canadian Irradiation Center, INRS-Institut Armand-Frappier, Institute of Nutraceutical and Functional Foods, 531 Boulevard des Prairies, Laval, Québec, H7V 1B7, Canada.

Some pathogens might develop favorable global adaptation in response to certain stress treatments resulting in enhanced virulence and/or resistance to a different stress. β-lactam resistance, as well as and genes involved in this resistance, were studied to evaluate their possible role in O157:H7 () radioresistance. adapted to 25, 15 or 7 μg/mL of kanamycin or carbenicillin, were produced and treated with sensitization (0. Read More

View Article
December 2018

Frailty significantly impairs the short term prognosis in elderly patients with heart failure.

J Geriatr Cardiol 2018 Nov;15(11):675-681

Cukurova University, Faculty of Medicine, Department of Cardiology, Adana, Turkey.

Background: Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients.

Methods: We included patients aged ≥ 65 years with the diagnosis of heart failure. Read More

View Article
November 2018

Complete Genome Sequences of Canadian Epidemic Methicillin-Resistant Staphylococcus aureus Strains CMRSA3 and CMRSA6.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Centre for Antimicrobial Resistance, Alberta Health Services/Calgary Laboratory Services/University of Calgary, Calgary, Alberta, Canada.

Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. The Canadian epidemic MRSA strains CMRSA3 and CMRSA6 are moderately virulent members of this group but are closely related to the highly virulent strain TW20. Whole-genome sequencing of CMRSA3 and CMRSA6 was conducted to identify genetic determinants associated with their virulence. Read More

View Article

Saproxylic Diptera assemblages in a temperate deciduous forest: implications for community assembly.

PeerJ 2018 4;6:e6027. Epub 2018 Dec 4.

Department of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, QC, Canada.

Saproxylic insects, those associated directly or indirectly with decaying wood for all or part of their life cycle, compose a large proportion of forest organisms. Flies (Diptera) are often the most abundant and species-rich group of insects in forest microhabitats, yet most work to date on saproxylic insect diversity and ecology has focused on beetles (Coleoptera). We compared saproxylic Diptera assemblages reared from two tree species (sugar maple and American beech) at two stages of decay (early/young and advanced/old) for a total of 20 logs in an eastern Canadian Nearctic old-growth forest. Read More

View Article
December 2018

Essentials of extracellular vesicles: posters on basic and clinical aspects of extracellular vesicles.

J Extracell Vesicles 2018 30;7(1):1548234. Epub 2018 Nov 30.

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.

The past decade has witnessed an exponential development in the field of extracellular vesicles. Sporadic observations have reached a critical level and the scientific community increasingly recognizes the potential biomedical significance of these subcellular structures present in all body fluids as significant components of the cellular secretome. The Educational Committee of the International Society for Extracellular Vesicles prepared two posters ("Basic aspects of extracellular vesicles" and "Clinical aspects of extracellular vesicles") to provide essential pieces of information on extracellular vesicles at glance for anyone not familiar with the field. Read More

View Article
November 2018

Experimental bacterial adaptation to the zebrafish gut reveals a primary role for immigration.

PLoS Biol 2018 Dec 10;16(12):e2006893. Epub 2018 Dec 10.

Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America.

All animals live in intimate association with microorganisms that profoundly influence their health and development, yet the traits that allow microorganisms to establish and maintain host associations are not well understood. To date, most investigations aimed at identifying traits required for host association have focused on intrahost niches. Consequently, little is known about the relative contribution of extrahost factors such as environmental growth and survival and immigration into hosts from the external environment, as promoters of host association. Read More

View Article
December 2018

qTorch: The quantum tensor contraction handler.

PLoS One 2018 10;13(12):e0208510. Epub 2018 Dec 10.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, United States of America.

Classical simulation of quantum computation is necessary for studying the numerical behavior of quantum algorithms, as there does not yet exist a large viable quantum computer on which to perform numerical tests. Tensor network (TN) contraction is an algorithmic method that can efficiently simulate some quantum circuits, often greatly reducing the computational cost over methods that simulate the full Hilbert space. In this study we implement a tensor network contraction program for simulating quantum circuits using multi-core compute nodes. Read More

View Article
December 2018

Cardiovascular Effects of Drugs Used to Treat Attention Deficit/Hyperactivity Disorder Part 2: Impact on Cardiovascular Events and Recommendations for Evaluation and Monitoring.

Cardiol Rev 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, Missouri.

A variety of psychostimulant and non-psychostimulant medications have proven to be successful in reducing inattention, impulsivity and hyperactivity in individuals with attention-deficit/hyperactivity disorder with (ADHD). Psychostimulants used to treat ADHD include methylphenidate and related drugs and various amphetamine preparations. Non-psychostimulant medications used to treat ADHD include atomoxetine and two alpha-2 adrenergic agonists; guanfacine extended-release and clonidine extended-release. Read More

View Article
December 2018

The Canadian Forces Cancer and Mortality Study II: a longitudinal record-linkage study protocol.

CMAJ Open 2018 Oct-Dec;6(4):E619-E627. Epub 2018 Dec 10.

Directorate of Force Health Protection (Rolland-Harris, Weeks, Simkus) and Directorate Mental Health (Zamorski, Boulos), Department of National Defence, Ottawa, Ont.; Research Directorate (VanTil, Simkus), Veterans Affairs Canada, Charlottetown, PEI; Statistics Canada (Reicker, Masoud, Trudeau), Ottawa, Ont.

Background: Military service exposes personnel to unusual situations with unclear health-related implications, and to identify both immediate and delayed risks, part of health surveillance includes examination of mortality and cancer rates that extends beyond periods of military service. The main aim of the Canadian Forces Cancer and Mortality Study II (CFCAMS II) is to describe the mortality and cancer experience of Canadian Armed Forces personnel (serving and released; about 230 000 people), with the further aim of informing health promotion and prevention programs for serving personnel and services for veterans after they leave the military.

Methods: This protocol is for a retrospective cohort study of serving and released Canadian Armed Forces personnel who enrolled on or after Jan. Read More

View Article
December 2018

Recommendations on screening for breast cancer in women aged 40-74 years who are not at increased risk for breast cancer.

CMAJ 2018 Dec;190(49):E1441-E1451

Department of Medicine (Klarenbach), University of Alberta, Edmonton, Alta.; Department of Family Medicine (Lewin), University of Ottawa, Ottawa, Ont.; Departments of Internal Medicine and Community Health Sciences (Singh), University of Manitoba, Winnipeg, Man.; Department of Family Medicine (Thériault), McGill University, Montréal, Que.; Department of Medicine (Tonelli), University of Calgary, Calgary, Alta.; Public Health Agency of Canada (Sims-Jones, Courage, Doull, Jaramillo Garcia), Ottawa, Ont.; Department of Psychiatry (Thombs), McGill University, Montréal, Que.

View Article
December 2018

Occurrence of and referral to specialists for pain-related diagnoses in First Nations and non-First Nations children and youth.

CMAJ 2018 Dec;190(49):E1434-E1440

Faculty of Health (Latimer), Dalhousie University; Centre for Pediatric Pain Research (Latimer, MacLeod, Sylliboy, Filiaggi, Finley), IWK Health Centre, Halifax, NS; Department of Integrated Studies (Sylliboy), McGill University, Montréal, Que.; Eskasoni Health Centre (Rudderham), Eskasoni, NS; Departments of Surgery (Lethbridge) and Anesthesia, Pain Management and Perioperative Medicine (Finley), and School of Physiotherapy (Harman), Dalhousie University, Halifax, NS.

Background: Indigenous youth have higher rates of chronic health conditions interfering with healthy development, including high rates of ear, dental, chest and musculoskeletal pain, as well as headache, arthritis and mental health issues. This study explores differences in pain-related diagnoses in First Nations and non-First Nations children.

Methods: Data from a study population of age- and sex-matched First Nations and non-First Nations children and youth were accessed from a specific region of Atlantic Canada. Read More

View Article
December 2018

Wise guidance and its challenges: the new Canadian recommendations on breast cancer screening.

CMAJ 2018 Dec;190(49):E1432-E1433

Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College, New York, NY

View Article
December 2018
1 Read

Operationalising a conceptual framework for a contiguous hospitalisation episode to study associations between surgical timing and death after first hip fracture: a Canadian observational study.

BMJ Open 2018 Dec 6;8(12):e020372. Epub 2018 Dec 6.

Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: We describe steps to operationalise a published conceptual framework for a contiguous hospitalisation episode using acute care hospital discharge abstracts. We then quantified the degree of bias induced by a first abstract episode, which does not account for hospital transfers.

Design: Retrospective observational study. Read More

View Article
December 2018

Changes in thyroid function of nestling tree swallows (Tachycineta bicolor) in relation to polycyclic aromatic compounds and other environmental stressors in the Athabasca Oil Sands Region.

Environ Res 2018 Nov 22;169:464-475. Epub 2018 Nov 22.

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, Canada T2N 4Z6.

In the Canadian Athabasca Oil Sands Region (AOSR), nestling tree swallows (Tachycineta bicolor) raised near mining-related activities accumulated greater concentrations of polycyclic aromatic compounds (PACs) that contributed to their poorer condition, growth, and reproductive success. Here, we report changes in thyroid function of the same 14 day old (do) nestlings (N ≤ 68) at these mining-related sites (OS1, OS2) compared to reference nestlings (REF1), and in relation to multiple environmental stressors that influence avian thyroid function. Thyroid function was compromised for OS1 nestlings but generally comparable between OS2 and REF1 chicks. Read More

View Article
November 2018

Spatial deconvolution of aerial radiometric survey and its application to the fallout from a radiological dispersal device.

J Environ Radioact 2018 Dec 5;197:39-47. Epub 2018 Dec 5.

Geological Survey of Canada, Natural Resources Canada, Ottawa, Ontario, Canada.

Mapping radioactive contamination using aerial survey measurements is an area under active investigation today. The radiometric aerial survey technique has been extensively applied following reactor accidents and also would provide a key tool for response to a malicious radiological or nuclear incident. Methods exist to calibrate the aerial survey system for quantification of the concentration of natural radionuclides, which can provide guidance. Read More

View Article
December 2018

Hemoglobin Optimization for Coronary Bypass: A Ten-Year Canadian Multicenter Experience.

Ann Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Division of Hematology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: We report our 10-year experience of a multicenter hemoglobin optimization program with the aim to reduce red blood cell transfusion in patients undergoing coronary artery bypass grafting (CABG).

Methods: From 2006 to 2016, patients undergoing CABG at 10 centers in Ontario were referred to the Ontario Transfusion Coordinators (ONTraC) program. Of these, we present data on the first 60 consecutive patients per center, per year (N=6145). Read More

View Article
December 2018

Oncologic and Surgical Outcomes of Robotic Versus Open Radical Hysterectomy for Cervical Cancer.

J Obstet Gynaecol Can 2018 Dec 7. Epub 2018 Dec 7.

Division of Gynecologic Oncology, Segal Cancer Centre, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, QC. Electronic address:

Objective: In view of the recent controversy concerning the use of minimally invasive radical hysterectomy as primary treatment for early stage cervical cancer, this study compared the survival and perioperative outcomes in a cohort of patients who underwent radical hysterectomy either by laparotomy or by robotics.

Methods: This retrospective study compared all consecutive patients with early stage cervical cancer since the beginning of the Division of Gynecologic Oncology at the Jewish General Hospital in 2003, who underwent robotic radical hysterectomy (n = 74) with a cohort of all consecutive patients from the immediate past who underwent open radical hysterectomy (n = 24) for early stage cervical cancer. All patients were treated at the Jewish General Hospital in Montréal (Canadian Task Force Classification II-2). Read More

View Article
December 2018

Assessment of Malnutrition Risk in Canadian Pediatric Hospitals: A Multicenter Prospective Cohort Study.

J Pediatr 2018 Oct 24. Epub 2018 Oct 24.

Research Centre, CHU Sainte-Justine, Montreal, Quebec, Canada; Department of Nutrition Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Objective: To assess the prevalence, causes, and consequences of malnutrition, as well as the evolution of nutritional status, in Canadian pediatric health care institutions.

Study Design: In this multicenter prospective cohort study, a total of 371 patients were recruited from pediatric hospitals in 5 Canadian provinces. Subjects were aged 1 month to 18 years; admitted to a medical, surgical, or oncology ward; and had a planned hospital stay of >48 hours. Read More

View Article
October 2018

The State of Needlestick Training for Undergraduate Medical Students at Canadian Universities.

J Obstet Gynaecol Can 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON; Department of Obstetrics and Gynaecology, St. Michael's Hospital, Toronto, ON. Electronic address:

Canadian undergraduate medical students sustain needlestick injuries, which have adverse implications, including blood-borne illnesses and personal anxiety. This study sought to determine students' needle handling efficacy and to examine the prevalence of formal training around needlestick safety and reporting procedures both nationally and, specifically, within the University of Toronto in Toronto, Ontario (U of T). A seven-question survey electronic survey was distributed to 116 undergraduate medical education (UME) leaders practising in high-risk rotations at 13 Canadian universities. Read More

View Article
December 2018

Effectiveness of hysteroscopic techniques for endometrial polyps removal: the italian multicenter Trial.

J Minim Invasive Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Women's Health and Territorial Medicine, University of Rome "La Sapienza", Rome, Italy.

Study Objective: To compare the effectiveness and safety of different techniques of hysteroscopic polypectomy.

Design: Multicenter, prospective observational trial (Canadian Task Force Classification II-2).

Setting: 19 Italian Gynecologic Departments (University-Affiliated or Public Hospitals). Read More

View Article
December 2018

Para-cervical block as a strategy to reduce postoperative pain after laparoscopic hysterectomy: A randomized controlled trial.

J Minim Invasive Gynecol 2018 Dec 6. Epub 2018 Dec 6.

University of Tennessee College of Medicine, Chattanooga. Department of Obstetrics and Gynecology. 979 E. 3rd Street - Suite C720. Chattanooga, TN 37403.

Study Objective: To determine if performing a para-cervical block with 0.5% bupivacaine prior to laparoscopic hysterectomy reduces post-operative pain.

Design: Double-blind randomized controlled trial (Canadian Task Force classification I). Read More

View Article
December 2018

Motivation for participating in phase 1 vaccine trials: Comparison of an influenza and an Ebola randomized controlled trial.

Vaccine 2018 Dec 6. Epub 2018 Dec 6.

Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and the Nova Scotia Health Authority, Halifax, Nova Scotia, Canada; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

Introduction/hypothesis: Recruitment of participants into phase 1 vaccine clinical trials can be challenging since these vaccines have not been used in humans and there is no perceived benefit to the participant. Occasionally, as was the case with a phase 1 clinical trial of an Ebola vaccine in Halifax, Canada, during the 2014-2016 West African Ebola virus outbreak, recruitment is less difficult. In this study, we explored the motivations of participants in two phase 1 vaccine trials that were concurrently enrolling at the same centre and compared the motivations of participants in a high-profile phase 1 Ebola vaccine trial to those in a less high-profile phase 1 adjuvanted seasonal influenza vaccine study. Read More

View Article
December 2018

The Muskox Lost a Substantial Part of Its Genetic Diversity on Its Long Road to Greenland.

Curr Biol 2018 Nov 28. Epub 2018 Nov 28.

Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address:

The muskox (Ovibos moschatus) is the largest terrestrial herbivore in the Arctic and plays a vital role in the tundra ecosystem [1-4]. Its range, abundance, and genetic diversity have declined dramatically over the past 30,000 years [5]. Two subspecies are recognized, but little is known about the genetic structure and how this relates to the species history. Read More

View Article
November 2018

Receptiveness to Patient-Delivered Partner Therapy (PDPT) for Chlamydia Infection: Exploratory Findings From a Sample of Canadian Youth.

J Obstet Gynaecol Can 2018 Oct 24. Epub 2018 Oct 24.

Department of Paediatrics, Section on Paediatric and Adolescent Gynaecology, The Hospital for Sick Children, Toronto, ON.

Objectives: To determine hypothetical receptiveness among Canadian 15-24 year old youth to providing and receiving patient-delivered partner therapy (PDPT) for Chlamydia trachomatis infection and to explore patient characteristics associated with receptiveness.

Methods: An anonymous cross-sectional survey was administered to a convenience sample of 312 youth ages 15-24 years presenting to a youth-focused community health centre (CHC) in Ajax, ON. The survey probed comfort with PDPT for chlamydia, both if the respondent was the hypothetical index case or the hypothetical partner. Read More

View Article
October 2018

A Canadian national survey: understanding the differences in management of cryptorchidism among pediatric surgeons and pediatric urologists.

J Pediatr Surg 2018 Oct 29. Epub 2018 Oct 29.

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada.

Background: This investigation aims to assess the variability in practice patterns regarding management of children with cryptorchidism (UDT) among pediatric urologists (U) and pediatric surgeons (S) practicing in Canada.

Methods: All active members of Pediatric Urologists of Canada (PUC) and Canadian Association of Pediatric Surgery (CAPS) were invited to participate in an online multiple-choice type questionnaire with clinical scenarios in management of UDT. Responses were compared between U and S using Fisher's exact test. Read More

View Article
October 2018

Return to emergency department after pediatric urology procedures.

J Pediatr Urol 2018 Nov 2. Epub 2018 Nov 2.

Division of Urology, The Hospital for Sick Children-Toronto, Canada.

Background: Unplanned postoperative return visits to the emergency department (ED) and readmission represent a quality bench outcome and pose a considerable cost burden to health-care systems.

Objective: The aim of this study is to evaluate ED return visits after pediatric urology procedures in a tertiary care children's hospital, trying to identify potential causes. This may constitute a platform for future improvement areas. Read More

View Article
November 2018

The Potential Dangers of Recruitment Maneuvers During One Lung Ventilation Surgery.

J Surg Res 2019 Feb 11;234:178-183. Epub 2018 Oct 11.

Division of Thoracic Surgery, Western University, London, Ontario, Canada.

Background: Existing evidence regarding lung-protective ventilation (LPV) during one-lung ventilation (OLV) focuses on surrogate outcomes. Our objective was to assess whether an LPV protocol during OLV surgery is associated with reduced respiratory complications.

Materials And Methods: This was a matched control retrospective cohort study of patients undergoing pulmonary resection at a tertiary Canadian hospital. Read More

View Article
February 2019

Association of frailty index with perioperative mortality and in-hospital morbidity after elective lower extremity bypass.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Vascular and Endovascular Surgery, Boston University School of Medicine, Boston, Mass.

Objective: The frailty index has been linked to adverse outcomes after surgical procedures. In this study, we evaluated the association between frailty index and outcomes after elective lower extremity bypass (LEB) for lower extremity ischemia.

Methods: The American College of Surgeons National Surgical Quality Improvement Program data set (2005-2012) was used to identify patients who underwent elective LEB using diagnostic and procedure Current Procedural Terminology codes. Read More

View Article
October 2018

A Population-Based Study of Adherence to Guideline Recommendations and Appropriate-Use Criteria for Implantable Cardioverter Defibrillators.

Can J Cardiol 2018 Dec 24;34(12):1677-1681. Epub 2018 Aug 24.

Mazankowski Alberta Heart Institute, University of Alberta, Division of Cardiology, Edmonton, Alberta, Canada. Electronic address:

Studies evaluating physician adherence to guideline recommendations for implantable cardioverter defibrillator (ICD) therapy are sparse, and none exist for the application of appropriate-use criteria (AUC) in clinical practice. As part of a quality improvement initiative, a review of all ICD procedures was performed from January 1, 2015 to December 31, 2016 in Alberta, Canada, to evaluate the proportion of patients receiving appropriate ICD therapy and to identify reasons for nonadherence. Our device-implant process involves an electrophysiologist or implanting cardiologist evaluation, reminders of ICD eligibility criteria on the device requisition, and peer-review consensus. Read More

View Article
December 2018

Improving Quality of Congenital Heart Disease Research in Canada: Standardizing Nomenclature Across Canada.

Can J Cardiol 2018 Dec 29;34(12):1674-1676. Epub 2018 Aug 29.

Department of Pediatrics, Université de Sherbrooke, and Centre de recherche du centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

In an effort to improve the quality of interinstitutional and nation-wide research into congenital heart disease (CHD) in Canada, the authors propose the national implementation of a single nomenclature list for CHD as a first step towards achieving a common disease classification system in all Canadian institutions that deal with congenital heart malformations. The authors offer a brief overview of the history and state of nomenclature for CHD in Canada and recommend the national use of the CHD diagnostic list that was recently finalized by the International Society for Nomenclature of Paediatric and Congenital Heart Disease. This list was submitted to the World Health Organization for incorporation into the 11th iteration of the International Classification of Diseases and was recently translated into French by members of the International Society for Nomenclature of Paediatric and Congenital Heart Disease. Read More

View Article
December 2018

Poor Adherence to Dietary Guidelines Among French-Speaking Adults in the Province of Quebec, Canada: The PREDISE Study.

Can J Cardiol 2018 Dec;34(12):1665-1673

Institute of Nutrition and Functional Foods, Université Laval, Quebec, Canada; School of Nutrition, Université Laval, Quebec, Canada. Electronic address:

Background: Regular monitoring of the population's food and nutrient intake is essential to develop effective nutrition-focused public health policies. The aim of this study was to provide dietary intake estimates using an age- and sex-representative sample of French-speaking adults with Internet access from 5 administrative regions in the province of Quebec, Canada.

Methods: PRÉDicteurs Individuels, Sociaux et Environnementaux (PREDISE) is a multicentre cross-sectional study that used a Web-based approach to collect individual, social, and environmental data on factors associated with adherence to dietary recommendations. Read More

View Article
December 2018

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Can J Cardiol 2018 Dec;34(12):1553-1563

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montréal, Quebec, Canada; Department of Medicine, McGill University, Montréal, Quebec, Canada.

Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are undiagnosed. Herein, we provide an update of the 2014 Canadian Cardiovascular Society position statement on FH addressing the need for case identification, prompt recognition, and treatment with statins and ezetimibe, and cascade family screening. Read More

View Article
December 2018