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    5730 results match your criteria Canadian Journal of Cardiology[Journal]

    1 OF 115

    Impact of Injectable Furosemide Hospital Shortage on Congestive Heart Failure Outcomes: A Time Series Analysis.
    Can J Cardiol 2017 Nov 12;33(11):1498-1504. Epub 2017 Sep 12.
    Division of Nephrology, Western University, London, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address:
    Background: Beginning in February 2012, there was a shortage of injectable furosemide in the province of Ontario, Canada. The objective of this study was to assess the effects of the furosemide shortage on heart failure outcomes in Ontario, Canada.

    Methods: We determined which hospitals experienced a shortage of injectable furosemide using an online survey. Read More

    Mind the Gap: Current Challenges and Future State of Heart Failure Care.
    Can J Cardiol 2017 Nov 5;33(11):1434-1449. Epub 2017 Sep 5.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
    The past decade has seen many advances in the management of heart failure (HF) that have improved survival and quality of life for patients living with this condition. A number of gaps remain in our understanding of the pathophysiology of HF, and the application of emerging treatment strategies is an exciting but daunting challenge. It is possible that advances in genetic evaluation of cardiomyopathy will provide a more refined approach to characterizing HF syndromes, whereas large-scale clinical trials on the horizon should further clarify the role of novel pharmacologic agents and invasive therapies. Read More

    2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure.
    Can J Cardiol 2017 Nov 6;33(11):1342-1433. Epub 2017 Sep 6.
    Memorial University, St John's, Newfoundland, Canada.
    Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in 2006, much has changed in the care for patients with HF. Over the past decade, the HF Guidelines Committee has published regular updates. However, because of the major changes that have occurred, the Guidelines Committee believes that a comprehensive reassessment of the HF management recommendations is presently needed, with a view to producing a full and complete set of updated guidelines. Read More

    Recurrent Strokes After Gore Septal Occluder Device Closure of Atrial Septal Defect.
    Can J Cardiol 2017 Sep 1. Epub 2017 Sep 1.
    Division of Pediatric Cardiology, Izaak Walton Killam Health Centre/Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada. Electronic address:
    We report a case of recurrent strokes in a healthy teenager after complete closure of atrial septal defect with Gore Septal Occluder (W.L. Gore and Associates, Newark, DE) device. Read More

    Timing of Conduction Abnormalities Leading to Permanent Pacemaker Insertion After Transcatheter Aortic Valve Implantation-A Single-Centre Review.
    Can J Cardiol 2017 Sep 1. Epub 2017 Sep 1.
    University of Toronto, Toronto, Ontario, Canada; Division of Cardiology and Cardiac Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: Transcatheter aortic valve implantation (TAVI) is the preferred alternative to traditional surgical aortic valve replacement; however, it remains expensive. One potential driver of cost is the need for postprocedural monitoring for conduction abnormalities after TAVI. Given the paucity of literature on the optimal length of monitoring, we aimed to determine when clinically significant conduction abnormalities leading to permanent pacemaker (PPM) insertion after TAVI were first identified. Read More

    Syncope and Presyncope as a Presenting Symptom or Discharge Diagnosis in the Emergency Department: An Administrative Data Validation Study.
    Can J Cardiol 2017 Sep 11. Epub 2017 Sep 11.
    Centre for Clinical Epidemiology & Evaluation, Vancouver, British Columbia, Canada; Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Emergency department (ED) visits for syncope are common. Validation of ED administrative diagnostic coding for syncope is required before these codes can be used for health services research. We performed a retrospective multicentre chart review using a regional ED database in British Columbia. Read More

    Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management.
    Can J Cardiol 2017 Sep 14. Epub 2017 Sep 14.
    Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Autonomic Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:
    Presyncope and syncope are common medical findings, with a > 40% estimated lifetime prevalence. These conditions are often elicited by postural stress and can be recurrent and accompanied by debilitating symptoms of cerebral hypoperfusion. Therefore, it is critical for physicians to become familiar with the diagnosis and treatment of common underlying causes of presyncope and syncope. Read More

    Development of Mitral Stenosis After Mitral Valve Repair: Importance of Mitral Valve Area.
    Can J Cardiol 2017 Sep 11. Epub 2017 Sep 11.
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
    Background: The development of mitral stenosis (MS) is not uncommon after mitral valve (MV) repair for degenerative mitral regurgitation (MR), but the significance of MS in this setting has not been defined.

    Methods: We prospectively studied 110 such patients who underwent supine bicycle exercise testing to assess intracardiac hemodynamics at rest and at peak exercise. B-type natriuretic peptide (BNP) levels were measured at rest and after the exercise test. Read More

    Anticoagulation for Thromboembolic Risk Reduction in Adults With Congenital Heart Disease.
    Can J Cardiol 2017 Aug 19. Epub 2017 Aug 19.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
    Adults with congenital heart disease (ACHD) represent one of the fastest expanding groups of patients in contemporary practice with unique and often complex management pathways. ACHD have a higher risk of thromboembolism not only from their complex physiology and anatomy but also from substrates such as valvular heart disease, atrial arrhythmias, cyanosis, and ventricular dysfunction, resulting in significant morbidity and mortality. Thromboembolic event rates in ACHD have been shown to be related to Congestive Heart Failure, Hypertension, Age (≥75 years), Diabetes, Stroke/Transient Ischemic Attack, Vascular Disease, Age (65-74 years), Sex (Female) (CHA2DS2-VASc) scores (0. Read More

    Delayed Formation of a Massive Atrial Hematoma After Coronary Intervention Manifesting With an Isolated Cough: Multimodality Imaging and Outcome.
    Can J Cardiol 2017 Aug 16. Epub 2017 Aug 16.
    Service de cardiologie, Hopital nord franche comté, Trévenans, France. Electronic address:
    Coronary artery perforation is a relatively rare but potentially life-threatening complication of percutaneous coronary intervention because it could result in cardiac tamponade; exceptionally, distal coronary perforation could cause an acute formation of a mural hematoma, which could also prove lethal without adequate management. We report an exceptional case of a 76-year-old man in whom an important left atrial hematoma formed progressively over weeks after a planned percutaneous coronary intervention and manifested with an isolated cough. Diagnosis was made using multimodality imaging. Read More

    Midterm Angina-Related Quality of Life Benefits After Percutaneous Coronary Intervention of Chronic Total Occlusions.
    Can J Cardiol 2017 Aug 19. Epub 2017 Aug 19.
    McGill University Health Centre, McGill University, Montreal, Quebec, Canada; Quebec Heart and Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:
    Background: Data on the impact of coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI) on quality of life (QOL) are limited. To date, studies have been limited in sample size and have focused on only a few domains of the Seattle Angina Questionnaire (SAQ). We evaluated the relationship between coronary CTO PCI and QOL in patients with symptoms of angina, incorporating all aspects of the SAQ. Read More

    Heart Rate Response in Spectators of the Montreal Canadiens Hockey Team.
    Can J Cardiol 2017 Sep 28. Epub 2017 Sep 28.
    Montreal Heart Institute Research Center, Université de Montréal, Montreal, Quebec, Canada. Electronic address:
    Background: To our knowledge, heart rate responses have not previously been assessed in hockey fans. We quantified heart rate increases in spectators of the Montreal Canadiens, compared televised with live games, explored features associated with peak heart rates, and assessed whether increases correlate with a fan passion score.

    Methods: Healthy adults were enrolled, with half attending live games and half viewing televised games. Read More

    Volume and Patterns of Physical Activity Across the Health and Heart Failure Continuum.
    Can J Cardiol 2017 Nov 18;33(11):1465-1471. Epub 2017 Jul 18.
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
    Background: The benefits of regular physical activity (PA) are well documented in patients with heart failure (HF), however the amount and intensity of objectively measured PA and sedentary behaviour in HF with preserved (HFPEF) or reduced ejection fraction (HFREF) is not well known.

    Methods: In a cross-sectional observational study the energy expenditure of 151 participants (HFPEF: n = 53; HFREF: n = 16; at-risk for HF: n = 48; control participants: n = 34) using SenseWear Mini Armbands (Body Media, Inc, Pittsburgh, PA) were monitored. PA outcomes included time spent in different PA intensities (light and moderate-vigorous PA), sedentary time, steps per day, total daily energy expenditure, PA energy expenditure, and the patterns of PA in bouts of ≥ 10 minutes of moderate-vigorous PA. Read More

    Relationships Between Periventricular Epicardial Adipose Tissue Accumulation, Coronary Microcirculation, and Left Ventricular Diastolic Dysfunction.
    Can J Cardiol 2017 Nov 7;33(11):1489-1497. Epub 2017 Aug 7.
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Background: Obesity is related to left ventricular (LV) diastolic dysfunction, although its pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) is an ectopic fat with paracrine effects on coronary circulation and myocardium. We hypothesized that left ventricle-specific (periventricular) EAT may deteriorate diastolic function by impairing coronary microcirculation. Read More

    Impaired Cardiac Function and Cognitive Brain Aging.
    Can J Cardiol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address:
    It is well established that patients with heart failure are at a greater risk for dementia. Recent evidence suggests that the heart-brain link goes beyond advanced heart failure, and even suboptimal cardiac function is associated with brain structural and functional changes leading to cognitive impairment. In this review, we address several pathophysiological mechanisms underlying this association, including hemodynamic stress and cerebral hypoperfusion, neuroinflammation, cardiac arrhythmias, and hypercoagulation. Read More

    N-Terminal Pro B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T Levels Are Related to the Extent of Hibernating Myocardium in Patients With Ischemic Heart Failure.
    Can J Cardiol 2017 Nov 27;33(11):1478-1488. Epub 2017 Jun 27.
    Molecular Function and Imaging Program, The National Cardiac PET Centre, and the Advanced Heart Disease Program, Division of Cardiology, Department of Medicine, and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
    Background: Increased N-terminal pro b-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) can identify patients with heart failure (HF) who are at increased risk of cardiac events. The relationship of these biomarkers to the extent of hibernating myocardium and scar has not been previously characterized in patients with ischemic left ventricular dysfunction and HF.

    Methods: Patients with ischemic HF meeting recruitment criteria and undergoing perfusion and fluorodeoxyglucose-positron emission tomography to define myocardial hibernation and scar were included in the study. Read More

    Heart Failure in Young Adults Is Associated With High Mortality: A Contemporary Population-Level Analysis.
    Can J Cardiol 2017 Nov 19;33(11):1472-1477. Epub 2017 Jun 19.
    Division of Cardiology and Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada; Canadian Vigour Centre, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
    Background: Data on young patients with heart failure (HF) are sparse. We examined the characteristics, health care use, and survival of younger vs older patients with HF.

    Methods: We performed an analysis of linked administrative databases in Alberta, Canada. Read More

    Recipient Atrial Fibrillation Manifesting as an Irregular Monomorphic Atrial Tachycardia in the Donor Heart.
    Can J Cardiol 2017 Oct 3;33(10):1336.e5-1336.e8. Epub 2017 Aug 3.
    Cardiology, University Hospital Geneva, Geneva, Switzerland. Electronic address:
    A 63-year-old man presented with a 1-year history of atrial tachycardia (AT) 6 years after orthotopic heart transplantation with bicaval anastomosis. Twelve-lead electrocardiogram showed monomorphic AT with isoelectric intervals across all leads and strikingly irregular PP intervals. At electrophysiology study, the native left atrium's rhythm was atrial fibrillation (AF) while the donor atria exhibited centrifugal activation of irregular cycle length originating from a site along the left atrial anastomosis. Read More

    Quality of Acute Myocardial Infarction Care in Canada: A 10-Year Review of 30-Day In-Hospital Mortality and 30-Day Hospital Readmission.
    Can J Cardiol 2017 Oct 8;33(10):1319-1326. Epub 2017 Jul 8.
    Department of Medicine, University of Alberta, Edmonton, Alberta; Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
    Background: The recently released Canadian cardiac care quality indicators include 30-day in-hospital mortality and readmission rates after percutaneous coronary intervention (PCI) and isolated coronary artery bypass grafting (CABG). We examined long-term trends and provincial variations in these outcomes among acute myocardial infarction (AMI) patients.

    Methods: We included patients aged 18 years and older who were hospitalized with a primary diagnosis of AMI between 2004 and 2013 in all Canadian provinces except Quebec. Read More

    Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.
    Can J Cardiol 2017 Oct 29;33(10):1312-1318. Epub 2017 Jul 29.
    Nutrition, Metabolism, and Atherosclerosis Clinic, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada; Division of Medical Biochemistry, Department of Medicine, McGill University, Montréal, Québec, Canada. Electronic address:
    Background: Familial hypercholesterolemia (FH) is a monogenic disease associated with elevated low-density lipoprotein (LDL) cholesterol and oxidized LDL (oxLDL) leading to premature cardiovascular disease. Lectin-like oxLDL receptor-1 (LOX1) is one of the major contributors of oxLDL uptake and degradation in macrophages, which leads to foam cell formation and the development of atherosclerosis. This study investigated the effect of the rs11053646 genotype of the oxidized low-density lipoprotein receptor 1 (OLR1) gene on coronary artery disease (CAD) risk in a cohort of FH patients. Read More

    Association of Apolipoproteins B and A-1 With Markers of Vascular Health or Cardiovascular Events.
    Can J Cardiol 2017 Oct 16;33(10):1305-1311. Epub 2017 Aug 16.
    Population Health Research Institute and Department of Medicine, McMaster University Hamilton, Hamilton, Ontario, Canada. Electronic address:
    Background: Apolipoprotein B (apoB) and apolipoprotein A-1 (apoA-1) are markers of lipoprotein metabolism. Although their relationship to cardiovascular disease has been well documented, little is known regarding their correlation to measures of vascular structure and function. This study was conducted to investigate the relationship between apoA-1, apoB, and measures of vascular function, as well their relationship to adverse cardiovascular events. Read More

    Economic Evaluation of Left Ventricular Assist Devices for Patients With End Stage Heart Failure Who Are Ineligible for Cardiac Transplantation.
    Can J Cardiol 2017 Oct 21;33(10):1283-1291. Epub 2017 Jul 21.
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Background: Continuous flow (CF) left ventricular assist devices (LVADs) improve survival in end-stage heart failure patients who are ineligible for cardiac transplantation. Their use in this population (referred to as destination therapy) is increasing in many countries, yet they are not routinely funded for this indication in Canada. We assessed the cost-effectiveness of destination therapy CF-LVADs from the perspective of the Canadian health care payer. Read More

    Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial.
    Can J Cardiol 2017 Oct 31;33(10):1274-1282. Epub 2017 Jul 31.
    Department of Medicine, Montreal Heart Institute, Montreal, Québec, Canada. Electronic address:
    Background: Studies comparing biventricular (BiV) cardiac resynchronization therapy (CRT) and left ventricular (LV) pacing alone have yielded conflicting results. We recently reported the results of the Greater Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) trial demonstrating similar clinical benefits of BiV and LV-CRT on exercise tolerance. We report the prespecified secondary outcomes of the GREATER-EARTH trial, comparing the impact of BiV vs LV-CRT on structural and biochemical cardiac remodelling. Read More

    New Developments in Hypertrophic Cardiomyopathy.
    Can J Cardiol 2017 Oct 20;33(10):1254-1265. Epub 2017 Jul 20.
    Department of Cardiology, Motol University Hospital and 2nd Medical School, Charles University, Prague, Czech Republic.
    Hypertrophic cardiomyopathy is the leading cause of sudden death in young individuals and an important cause of heart failure at any age. In this review we discuss advances in investigation and management of this heterogenous disease. Improved cardiac imaging has allowed us to detail many of the structural abnormalities whereas the use of new techniques, predominantly in cardiac magnetic resonance imaging, has given us a greater insight in to tissue architecture, mechanism of contractile abnormalities, and function. Read More

    Prevention of Left Ventricular Thrombus Formation and Systemic Embolism After Anterior Myocardial Infarction: A Systematic Literature Review.
    Can J Cardiol 2017 Oct 1;33(10):1229-1236. Epub 2017 Aug 1.
    Cardiology Service, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada. Electronic address:
    Background: Anterior myocardial infarction (MI) with apical dysfunction is associated with an increased risk of left ventricular thrombus (LVT) formation and systemic embolism (SE). However, the role for prophylactic anticoagulation in current practice is a matter of debate.

    Methods: We conducted a systematic review of peer-reviewed original articles in either English or French on the benefit of combining anticoagulation with standard therapy for the prevention of LVT/SE after MI by searching PubMed, Ovid/MedLine/Embase, the Cochrane Library, and Google Scholar. Read More

    Current Risk of Contrast-Induced Acute Kidney Injury After Coronary Angiography and Intervention: A Reappraisal of the Literature.
    Can J Cardiol 2017 Oct 3;33(10):1225-1228. Epub 2017 Aug 3.
    Division of Interventional Cardiology, Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Milan, Italy.
    Contrast-induced acute kidney injury (CI-AKI) is the acute impairment of renal function further to the intravascular administration of iodinated contrast media, and occurs most frequently after coronary angiography, percutaneous coronary intervention, and contrast-enhanced computed tomography. CI-AKI has been associated with the development of acute renal failure, worsening of chronic kidney disease, requirement for dialysis, prolonged hospital stay, and higher mortality rates and health care costs. Recently, a number of studies suggested that contrast media exposure might not be the causative agent in the occurrence of acute kidney injury, particularly in stable patients who receive small to moderate amounts of contrast media. Read More

    Challenging Occam's Razor: An Unusual Combination of Sarcoidosis and Amyloidosis. The Value of Cardiac Magnetic Resonance Imaging in Infiltrative Cardiomyopathies.
    Can J Cardiol 2017 Oct 18;33(10):1335.e9-1335.e11. Epub 2017 Jul 18.
    Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom.
    We describe the case of a 66-year old woman with the extremely rare combination of sarcoidosis and amyloidosis (light chain) and the important role of cardiovascular magnetic resonance imaging to differentiate between these 2 infiltrative diseases. Myocardial characterization with T1 mapping can improve disease detection, especially in overlap cases, and possibly obviate the need for cardiac biopsy. Read More

    Implantable Cardioverter Defibrillator Implantation Rates After Out of Hospital Cardiac Arrest: Are the Rates Guideline-Concordant?
    Can J Cardiol 2017 Oct 7;33(10):1266-1273. Epub 2017 Sep 7.
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada. Electronic address:
    Background: Clinical practice guidelines recommend implantable cardioverter defibrillators (ICDs) for the secondary prevention of sudden death after a cardiac arrest not from a reversible cause, but "real world" implantation rates are not well described.

    Methods: Adults with out of hospital cardiac arrest attended by Emergency Medical Services are captured in the Toronto Regional RescuNET database. We analyzed those who survived to hospital discharge and collected data on age, sex, initial rhythm, ST-elevation myocardial infarction (STEMI) on presenting electrocardiogram (ECG), in-hospital revascularization, neurologic status (Modified Rankin Scale [MRS]) at discharge, and admission hospital type. Read More

    Effects of Hyperthyroidism on Coronary Artery Disease: A Computed Tomography Angiography Study.
    Can J Cardiol 2017 Oct 17;33(10):1327-1334. Epub 2017 Jul 17.
    Innsbruck Medical University, Department of Radiology, Innsbruck, Austria.
    Background: Changes in thyroid hormone concentration can negatively affect the cardiovascular system. Subclinical hyperthyroidism has been linked to an increase of cardiovascular heart disease, however, clinical effects and significance are still uncertain. Therefore, we analyzed coronary computed tomography angiographies of patients with overt and subclinical hyperthyroidism for quantitative parameters and plaque morphology. Read More

    Persistent Hypoxemia After Acute Myocardial Infarction: An Unexpected Culprit.
    Can J Cardiol 2017 Oct 29;33(10):1336.e1-1336.e3. Epub 2017 Jul 29.
    Department of Cardiology, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal.
    Hypoxemia after myocardial infarction (MI) is usually explained by common culprits, including congestive heart failure, pre-existing lung disease, and pulmonary infection. We report a case of a 60-year-old woman who experienced severe persistent hypoxemia caused by a patent foramen ovale in the setting of anterior MI complicated by a contained left ventricular rupture. Read More

    Histologically Proven Myocardial Carcinoid Metastases: The Value of Multimodality Imaging.
    Can J Cardiol 2017 Oct 16;33(10):1336.e9-1336.e12. Epub 2017 Jun 16.
    NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK; Imperial College London, National Heart and Lung Institute, London, UK. Electronic address:
    We present a case of a patient with intramyocardial metastases from a carcinoid tumor. These findings were detected using cardiovascular magnetic resonance imaging, with functional metabolic activity analyzed using nuclear imaging and confirmed by histologic findings at surgical biopsy. This case highlights the value of cardiovascular magnetic resonance imaging and the importance of multimodality imaging. Read More

    Utility of Unfractionated Heparin in Transradial Cardiac Catheterization: A Systematic Review and Meta-analysis.
    Can J Cardiol 2017 Oct 10;33(10):1245-1253. Epub 2017 Jun 10.
    Division of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
    Background: Unfractionated heparin (UFH) is purported to reduce the risk of radial artery occlusion (RAO) after transradial cardiac catheterization. However, the efficacy and optimal dose remain unclear. This meta-analysis evaluates the safety and efficacy of UFH in this context. Read More

    Score of Adherence to 2016 European Cardiovascular Prevention Guidelines Predicts Cardiovascular and All-Cause Mortality in the General Population.
    Can J Cardiol 2017 Oct 23;33(10):1298-1304. Epub 2017 Jun 23.
    Department of Epidemiology, Health Economics and Public Health, UMR1027 INSERM- Toulouse University, Toulouse University Hospital (CHU), Toulouse, France; Department of Cardiology B, Toulouse University Hospital, Toulouse, France. Electronic address:
    Background: Guidelines on cardiovascular (CV) disease prevention promote healthy lifestyle behaviours and CV risk factor control to reduce CV risk. The effect of adherence to these guidelines on CV and all-cause mortality is not well known.

    Methods: We assessed the effect of baseline adherence to "2016 European Guidelines on CV Disease Prevention in Clinical Practice" on long-term CV and all-cause mortality in a sample recruited from the French general population. Read More

    Between Disease-Causing and an Innocent Bystander: The Role of Titin as a Modifier in Hypertrophic Cardiomyopathy.
    Can J Cardiol 2017 10 21;33(10):1217-1220. Epub 2017 Jul 21.
    Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

    A Case of Cardiogenic Shock Secondary to Complement-Mediated Myopericarditis From Influenza B Infection.
    Can J Cardiol 2017 Oct 15;33(10):1335.e1-1335.e3. Epub 2017 Jun 15.
    Department of Cardiology, NYU Langone Medical Center, New York, New York, USA. Electronic address:
    Influenza B is a rare cause of myocarditis that is usually caused by histiocytic and mononuclear cellular infiltrates. We describe a 22-year-old female patient presenting with fulminant myopericarditis secondary to influenza B infection that deteriorated to cardiogenic shock. Endomyocardial biopsy results yielded myocardial necrosis through complement-mediated cellular injury without evidence of interstitial infiltrates. Read More

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