5,927 results match your criteria Canadian Journal of Cardiology[Journal]


Sudden Onset of Platypnea-Orthodeoxia Syndrome Caused by Traumatic Tricuspid Regurgitation With Ruptured Chordae Tendineae After Blunt Chest Trauma.

Can J Cardiol 2018 Apr 27. Epub 2018 Apr 27.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Read More

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Variability in Non-Vitamin K Antagonist Oral Anticoagulants Dose Adjustment in Atrial Fibrillation Patients With Renal Dysfunction: The Influence of Renal Function Estimation Formulae.

Can J Cardiol 2018 Apr 25. Epub 2018 Apr 25.

Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Non-vitamin K antagonist oral anticoagulants (NOACs) require renal dose adjustment. The most common estimates of renal function in clinical practice are derived from estimated glomerular filtration rate (eGFR; Modified Diet in Renal Disease [MDRD] or the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]). However, the landmark stroke prevention trials and product monographs recommend the use of the Cockcroft-Gault creatinine clearance equation (eCrCl) for drug eligibility and dose adjustment. Read More

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Cardiac Complications Associated With Checkpoint Inhibition: A Systematic Review of the Literature in an Important Emerging Area.

Can J Cardiol 2018 Mar 28. Epub 2018 Mar 28.

The Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada; The Division of Cardiology, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address:

Background: Immune checkpoint inhibitors, including programmed cell death-1, programmed cell death ligand-1 and cytotoxic lymphocyte antigen-4 inhibitors, have emerged as important therapeutic alternatives for advanced malignancies. This drug class upregulates T-cell activity, leading to an immune response against cancer cells. However, the increased activity of T cells can lead to autoimmune reactions. Read More

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Immune Checkpoint Inhibitors: Game Changing Cancer Therapy With a Cardiac Cost. What Are the Mechanisms and Unresolved Questions in Cardiotoxicity?

Can J Cardiol 2018 Apr 13. Epub 2018 Apr 13.

Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada.

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April 2018
2 Reads

A Case of Palpitations Due to T-Wave Oversensing Caused by Sacubitril/Valsartan.

Can J Cardiol 2018 Apr 5. Epub 2018 Apr 5.

Libin Cardiovascular Institute of Alberta, Cummings School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

A 58-year-old man with previous mitral/aortic mechanical-valve replacement, aortic root repair, and coronary disease developed severe left-ventricular dysfunction following AV-node ablation/single-chamber pacemaker implantation for management of atrial fibrillation. He then underwent an upgrade to cardiac resynchronization therapy with a defibrillator. To manage his heart failure better, angiotensin-receptor blocker therapy was changed to sacubitril/valsartan, after which symptomatic palpitations with T-wave oversensing occurred. Read More

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Geographical Differences in Comorbidity Burden and Outcomes in Adults With Syncope Hospitalizations in Canada.

Can J Cardiol 2018 Jul 16;34(7):937-940. Epub 2018 Apr 16.

University of Alberta, Division of Cardiology, Edmonton, Alberta, Canada. Electronic address:

A recent study found that rates of hospitalization for syncope vary across provinces; however, it is unknown whether differences in comorbidity burden and outcomes also exist. The Canadian Institute for Health Information Discharge Abstract Database was used to identify primary syncope hospitalizations (ICD-10 code R55) from 2004 to 2013 for all provinces (except Quebec). Charlson comorbidity score was calculated from comorbidities at the time of hospitalization. Read More

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July 2018
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Variation in Preparticipation Screening Medical Questionnaires and Physical Examinations Across Canadian Universities.

Can J Cardiol 2018 Jul 12;34(7):933-936. Epub 2018 Apr 12.

Department of Cardiology, Queen's University, Kingston, Ontario, Canada. Electronic address:

Pre-participation screening of athletes to prevent sudden cardiac arrest or death is endorsed by international guidelines. Standardized histories and physical examinations are recommended to optimize effectiveness. To assess current screening practices across Canada in the university athlete population, we sought to analyze the preparticipation screening form of all universities. Read More

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July 2018
1 Read

New Dimensions in Palliative Care Cardiology.

Authors:
Michael Slawnych

Can J Cardiol 2018 Jul 6;34(7):914-924. Epub 2018 Apr 6.

Libin Cardiovascular Institute and Division of Palliative Care, Department of Oncology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

The landscape of patient care at the beginning of the 19th century was dramatically different than it is today. With few good treatment options, illness courses were generally brief. Near the end of life, patients were attended to by spiritual advisors, not health care professionals. Read More

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July 2018
1 Read

Interventions to Mobilize Elderly Patients and Reduce Length of Hospital Stay.

Can J Cardiol 2018 Jul 9;34(7):881-888. Epub 2018 May 9.

Division of Geriatric Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

For older people, and in particular frail older people, acute illness and hospitalization are associated with significant potential harm. One of the major drivers of iatrogenic harm in older adults is hospital-induced immobility, the so-called "pajama paralysis." Older people in hospital are often confined to bed even after their acute illness has improved; not only by physical factors such as potentially unnecessary urinary catheters and monitoring equipment but also by the culture often found in hospital of keeping patients in bed for most of the day. Read More

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Heart Failure Management in Nursing Homes: A Scoping Literature Review.

Can J Cardiol 2018 Jul 11;34(7):871-880. Epub 2018 Apr 11.

Department of Medicine, Western University, London, Ontario, Canada.

Heart failure (HF) affects 20% of nursing home (NH) residents, causing high morbidity and mortality. The optimal approach to HF management in NHs remains elusive. We conducted a scoping review of published guidelines and HF management interventions in NHs. Read More

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July 2018
5 Reads

The Spoke-Hub-and-Node Model of Integrated Heart Failure Care.

Can J Cardiol 2018 Jul 4;34(7):863-870. Epub 2018 May 4.

Western University, London, Ontario, Canada. Electronic address:

Heart failure (HF) is a significant public health concern. Specialized HF clinics provide the optimal environment to address the complex needs of these patients and improve outcomes. The current and growing population of patients with HF outstrips the ability of these clinics to deliver care. Read More

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July 2018
2 Reads

Postoperative Remote Automated Monitoring: Need for and State of the Science.

Can J Cardiol 2018 Jul 25;34(7):850-862. Epub 2018 Apr 25.

McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

Worldwide, more than 230 million adults have major noncardiac surgery each year. Although surgery can improve quality and duration of life, it can also precipitate major complications. Moreover, a substantial proportion of deaths occur after discharge. Read More

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July 2018
4 Reads

"NEW" Prehabilitation: A 3-Way Approach to Improve Postoperative Survival and Health-Related Quality of Life in Cardiac Surgery Patients.

Can J Cardiol 2018 Jul;34(7):839-849

Schulich School of Medicine, Western University, London, Ontario, Canada.

With advances in health care practices and delivery, the overall life expectancy of the Western population has increased. For those practitioners involved in the care of the patient with advanced cardiac disease, there has been a resultant higher prevalence of increasingly frail and older patients undergoing complex cardiac procedures. The higher rates of comorbid-associated higher vulnerability, with associated deconditioning, predisposes older, frail patients to poorer postoperative outcomes and a complicated recovery process after cardiac surgery. Read More

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Decision Support Tools, Systems, and Artificial Intelligence in Cardiac Imaging.

Can J Cardiol 2018 Jul 9;34(7):827-838. Epub 2018 May 9.

Department of Medicine (Cardiology), University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Noninvasive cardiac imaging is widely used for the diagnosis and management of cardiac patients. The increasing demand for cardiac imaging begins to exceed the number of available interpreting physicians, leaving less time to interpret studies. In addition, the busy clinician is facing the increasingly daunting task of keeping abreast of current medical advancements and the ongoing changes in disease diagnosis and therapy. Read More

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July 2018
1 Read

Predictors of Cardiorespiratory Fitness Improvements With Cardiac Rehabilitation: Lower Baseline Fitness With the Most to Gain, Gains the Most.

Can J Cardiol 2018 Jul 25;34(7):819-820. Epub 2018 Apr 25.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas. Electronic address:

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Heart Teams: A New Paradigm in Health Care.

Can J Cardiol 2018 Jul 2;34(7):815-818. Epub 2018 Mar 2.

Clinical Services, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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July 2018
1 Read

Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization?

Can J Cardiol 2018 Apr 6. Epub 2018 Apr 6.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

Patients resuscitated from out-of-hospital cardiac arrest (OHCA) frequently have underlying coronary artery disease (CAD), but the relationship between the arrest and myocardial ischemia or infarction due to CAD can be difficult to discern in clinical practice. Patients often present with clinical profiles that guideline recommendations for appropriate implantable cardioverter-defibrillator use do not address. In cases of incomplete revascularization or mild but sustained impairment of ventricular function, it is not clear if the cause of the cardiac arrest is completely "reversible. Read More

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Risk of Cardiovascular Mortality Associated With Serum Sodium and Chloride in the General Population.

Can J Cardiol 2018 Mar 29. Epub 2018 Mar 29.

Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China. Electronic address:

Background: The prognostic value of serum chloride among patients with heart failure was demonstrated by previous studies. However, the association of serum chloride and risk of cardiovascular mortality among the general population remains unclear.

Methods: We included 16,483 participants in National Health and Nutrition Examination Survey III. Read More

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March 2018
3 Reads

Sodium, Chloride, and Cardiovascular Mortality-Open Access Data Is Worth Its Salt.

Authors:
James M Brophy

Can J Cardiol 2018 Apr 11. Epub 2018 Apr 11.

McGill University Health Center, Centre for Health Outcomes Research (CORE), Montreal, Québec, Canada. Electronic address:

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Comparison of Cardiac Magnetic Resonance Imaging and Echocardiography in Assessment of Left Ventricular Hypertrophy in Fabry Disease.

Can J Cardiol 2018 Mar 29. Epub 2018 Mar 29.

Department of Medical Genetics and Pediatrics, University of Calgary Cumming School of Medicine, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada. Electronic address:

Background: Cardiac hypertrophy in Fabry disease can be assessed using the left ventricular mass index (LVMI) with either echocardiography (LVMI-ECHO) or magnetic resonance imaging (LVMI-CMR).

Methods: A retrospective case series of patients with Fabry disease in Alberta involved a cross-sectional analysis of 32 patients and a longitudinal analysis of 14 of these patients with at least 4 serial CMR measurements.

Results: The cross-sectional analysis showed the mean LVMI-ECHO was 97. Read More

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Coronary Artery Bypass Grafting-The Long-term Solution?

Can J Cardiol 2018 Mar 20. Epub 2018 Mar 20.

Department of Surgery, Max Rady College of Medicine, University of Manitoba, and Cardiac Sciences Program, St Boniface Hospital, Winnipeg, Manitoba, Canada. Electronic address:

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Breaking Barriers: Mobile Health Interventions for Cardiovascular Disease.

Can J Cardiol 2018 Jul 11;34(7):905-913. Epub 2018 Jun 11.

University of Sydney, Sydney, New South Wales, Australia; Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia; The George Institute for Global Health, Sydney, New South Wales, Australia.

Cardiovascular disease (CVD) is a leading global cause of death and morbidity and prevention needs to be strengthened to tackle this. Mobile health (mHealth) might present a novel and effective solution in CVD prevention, and interest in mHealth has grown dramatically since the advent of the smartphone. In this review, we discuss mHealth interventions that target multiple cardiovascular risk factors simultaneously in the context of primary as well as secondary prevention. Read More

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Addition of Digoxin Improves Cardiac Function in Children With the Dilated Cardiomyopathy With Ataxia Syndrome: A Mitochondrial Cardiomyopathy.

Can J Cardiol 2018 Mar 1. Epub 2018 Mar 1.

Department of Pediatrics, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.

Background: The dilated cardiomyopathy with ataxia syndrome (DCMA) is a rare mitochondrial disorder characterized by progressive cardiomyopathy, prolonged QT interval and early death in childhood related to intractable heart failure. We present a case series of 9 children with DCMA who demonstrated functional improvement and favourable left ventricular remodeling only after digoxin was added to their medical therapy.

Methods: A retrospective review of 46 patients with DCMA followed at the Alberta Children's Hospital from 2005 to 2017 identified 9 patients who were treated with digoxin and had serial echocardiography data. Read More

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Factors Associated With Cardiorespiratory Fitness at Completion of Cardiac Rehabilitation: Identification of Specific Patient Features Requiring Attention.

Can J Cardiol 2018 Jul 30;34(7):925-932. Epub 2018 Mar 30.

TotalCardiology-Rehabilitation, Calgary, Alberta, Canada; Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California.

Background: We aimed to determine and compare predictors of postcardiac rehabilitation (CR) cardiorespiratory fitness (CRF), improvements in a large cohort of subjects with varying baseline CRF levels completing CR for ischemic heart disease and to refine prediction models further by baseline CRF.

Methods: The Alberta Provincial Project for Outcomes Assessment in Coronary Heart disease (APPROACH) and TotalCardiology (TotalCardiology, Inc, Calgary, Alberta, Canada) databases were used retrospectively to obtain information on 10,732 (1955 [18.2%] female; mean age 60. Read More

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Decision Support Tools: Realizing the Potential to Improve Quality of Care.

Can J Cardiol 2018 Jul 3;34(7):821-826. Epub 2018 Mar 3.

Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, Missouri, USA.

Delivering evidence-based, personalized care that engages patients requires profound changes in the structure, process, and organization of care, along with revised incentives to support such changes. Health care providers must absorb and apply a vast, usually overwhelming, amount of scientific information to provide high-quality patient care. Accordingly, care remains inconsistent, with unintentional adverse consequences. Read More

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Accounting for Complexity in Home Telemonitoring: A Need for Context-Centred Evidence.

Can J Cardiol 2018 Jul 31;34(7):897-904. Epub 2018 Jan 31.

Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Heart failure represents a significant burden for patients and the Canadian health care system. Home telemonitoring is proposed as an intervention that can improve heart failure outcomes by identifying opportunities for earlier clinical intervention and by providing patients with self-management support between scheduled clinic visits. The objective of this review is to provide clarity with respect to the most recent evidence of the effect of home telemonitoring on heart failure outcomes. Read More

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Vascular Plugging for the Enlarging Pulmonary Arteriovenous Malformation in a Patient With Idiopathic Pulmonary Artery Hypertension.

Can J Cardiol 2018 Jun 2;34(6):812.e9-812.e11. Epub 2018 Mar 2.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medicine, China Medical University, Taichung, Taiwan; Department of Medicine, Lin Shin Hospital, Taichung, Taiwan. Electronic address:

The coexistence of idiopathic pulmonary artery hypertension with pulmonary arteriovenous malformation (PAVM) is challenging because although the PAVM causes hypoxia and polycythemia with potential thrombotic complications, closing the PAVM increases pulmonary artery pressure. We report on a lady with PAVM and idiopathic pulmonary artery hypertension who, within 2 years of diagnosis, had an ischemic stroke, PAVM enlargement from 20 × 20 × 30 mm to 30x × 40 × 40 mm and oximetry decrease to 90%. Transcatheter occlusion of PAVM with a vascular plug was successful. Read More

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Hybrid Melody Valve Implantation in Mitral Position in a Child: Usefulness of a 3-Dimensional Printed Model for Preprocedural Planning.

Can J Cardiol 2018 Jun 19;34(6):812.e5-812.e7. Epub 2018 Feb 19.

Bordeaux University Hospital (CHU), Department of Paediatric and Adult Congenital Cardiology, Pessac, France; IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Bordeaux, France; INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.

We present the case of a 4-month-old child with atrioventricular canal associated with severe left atrioventricular valve dysfunction who previously underwent 3 surgical valve reconstructions without significant improvement. A Hybrid Melody valve (Medtronic, Minneapolis, MN) insertion was planned. Because of the low weight, the risk of left ventricular outflow tract obstruction was significant and therefore evaluated preprocedurally using a cardiac computed tomography-derived 3-dimensional printed model. Read More

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June 2018
2 Reads

Late-Onset Fulminant Myocarditis With Immune Checkpoint Inhibitor Nivolumab.

Can J Cardiol 2018 Jun 20;34(6):812.e1-812.e3. Epub 2018 Mar 20.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A 60-year-old man was diagnosed with melanoma. After receiving 13 infusions of nivolumab, he had fulminant myocarditis. The myocardial biopsy specimen revealed extensive lymphocytic infiltration, interstitial edema, and myocardial necrosis, with predominant CD4+, CD8+, CD20-, and programmed death-1- markers. Read More

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June 2018
1 Read

Erratum.

Authors:

Can J Cardiol 2018 Jun;34(6):811

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Canadian Registry of Implantable Electronic Device Outcomes: Surveillance of High-Voltage Leads.

Can J Cardiol 2018 Jun 19;34(6):808-811. Epub 2018 Feb 19.

Cardiovascular Research Methods Center, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Background: Cardiac implantable electrical devices (CIEDs) are subject to advisories and complications that can result in morbidity and mortality for patients; there is currently no system in Canada to track these.

Methods: This was a multicenter, prospective cohort study conducted at 5 centers to determine feasibility. Patients with a de novo high-voltage (HV) lead implantation were included and followed for a minimum of 1 year. Read More

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Factors Influencing Oral Anticoagulation Prescription for Patients Presenting to Emergency Departments With Atrial Fibrillation and Flutter.

Can J Cardiol 2018 Jun 24;34(6):804-807. Epub 2018 Mar 24.

Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Atrial fibrillation and atrial flutter (AF/AFL) are associated with an increased risk of stroke and systemic embolism. However, many patients are not started on guideline-recommended oral anticoagulation (OAC). We determined factors associated with initiation of OAC in eligible patients presenting to emergency departments. Read More

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Prevalence and Clinical Correlates of Sleep-Disordered Breathing in Patients Hospitalized With Acute Decompensated Heart Failure.

Can J Cardiol 2018 Jun 16;34(6):784-790. Epub 2018 Mar 16.

Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Background: Limited data are available regarding the presence of sleep-disordered breathing (SDB) assessed using polysomnography in patients hospitalized with left ventricular (LV) systolic dysfunction after acute decompensated heart failure (ADHF). We investigated the prevalence and clinical correlates of SDB in patients hospitalized with ADHF and LV systolic dysfunction.

Methods: Prospectively collected data from 105 consecutive patients with an LV ejection fraction < 50% who were hospitalized with ADHF from May 2012 to July 2014 were retrospectively assessed. Read More

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Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter-A Population-Based Study.

Can J Cardiol 2018 Jun 6;34(6):774-783. Epub 2018 Jan 6.

Institute for Clinical Evaluative Sciences, Western University, London, Ontario, Canada.

Background: The risk of stroke from atrial flutter and its relationship with progression to atrial fibrillation (AF) is unclear. This study describes the incidence of AF and stroke in patients with atrial flutter, and whether atrial flutter ablation attenuates the incidence of AF and stroke.

Methods: We performed a population-based retrospective cohort study of adults with typical atrial flutter with no AF history. Read More

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Feasibility and Outcomes in a Pilot Randomized Controlled Trial of a Psychosocial Intervention for Adults With Congenital Heart Disease.

Can J Cardiol 2018 Jun 2;34(6):766-773. Epub 2018 Mar 2.

Department of Psychology, York University, Toronto, Ontario, Canada.

Background: North American adults with congenital heart disease (CHD) are known to be at elevated risk of mood and anxiety disorders. This was the first trial of a group psychosocial intervention targeting this patient population.

Methods: Within this feasibility study, we conducted a 2-arm pilot randomized controlled trial (RCT) in which patients were randomized to Usual Care or an 8-session group psychosocial intervention (Adult Congenital Heart Disease-Coping and Resilience [ACHD-CARE]). Read More

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Longer Inflation Duration and Predilation-Sizing-Postdilation Improve Bioresorbable Scaffold Outcomes in a Long-term All-Comers Canadian Registry.

Can J Cardiol 2018 Jun 12;34(6):752-758. Epub 2018 Mar 12.

Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Centre Hospitalier de l'Université de Montréal, Research Center, Montréal, Québec, Canada. Electronic address:

Background: Real-world long-term safety and efficacy of the ABSORB (Abbott Vascular, Santa Clara, CA) bioresorbable vascular scaffold has not been well characterized in the literature, particularly in the setting of acute coronary syndromes (ACS). Herein, we report outcomes up to 4 years in such a high-risk cohort, with identification of parameters associated with better outcomes.

Methods: ReABSORB is a Canadian dual-centre, prospective, nonrandomized, all-comers registry consisting of 125 consecutively enrolled nontrial patients between October 2012 and December 2016. Read More

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June 2018
1 Read

Long-term Follow-up of the Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI).

Can J Cardiol 2018 Jun 10;34(6):736-743. Epub 2018 Feb 10.

St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada. Electronic address:

Background: The Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI) demonstrated superiority of routine early coronary angiography (and percutaneous coronary intervention [PCI]) compared with standard therapy in fibrinolytic-treated patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The aim of the current study was to evaluate the long-term (>7 year) effects of an early invasive strategy.

Methods: We linked the study cohort and administrative datasets to assess long-term follow-up status including repeat procedures, hospitalizations, and major adverse cardiovascular events (MACE). Read More

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Automated 3-Dimensional Single-Beat Real-Time Volume Colour Flow Doppler Echocardiography in Children: A Validation Study of Right and Left Heart Flows.

Can J Cardiol 2018 Jun 13;34(6):726-735. Epub 2018 Mar 13.

The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada. Electronic address:

Background: Novel quantification of stroke volume according to mitral inflow and aortic outflow using automated real-time 3-dimensional volume colour flow Doppler echocardiography (3D-RT-VCFDE) is more accurate than 2-dimensional echocardiography and has excellent correlation with cardiac magnetic resonance imaging-based flows in adults. This technology is applied for the first time to the right heart and in children.

Methods: 3D-RT-VCFDE was performed in 61 image sets of flow through the aortic (AV), mitral (MV), pulmonary (PV), and tricuspid (TV) valves of 34 children. Read More

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Subclinical Inflammation in Heart Failure: A Neutrophil Perspective.

Can J Cardiol 2018 Jun 31;34(6):717-725. Epub 2018 Jan 31.

Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Québec, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Québec, Canada. Electronic address:

Although it is widely recognized that inflammation plays a critical role in the development and pathology of heart failure (HF), very little is known about the involvement of one of the most abundant immune cells in the blood, a primary immune response cell: the neutrophil. This review summarizes the current literature on the role of subclinical inflammation, with a focus on the neutrophil in the pathophysiology of the HF syndrome. Some emerging therapeutic strategies are also discussed. Read More

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June 2018
2 Reads

Accounting for Selection Bias in Studies of Acute Cardiac Events.

Can J Cardiol 2018 Jun 31;34(6):709-716. Epub 2018 Jan 31.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

Background: In cardiovascular research, pre-hospital mortality represents an important potential source of selection bias. Inverse probability of censoring weights are a method to account for this source of bias. The objective of this article is to examine and correct for the influence of selection bias due to pre-hospital mortality on the relationship between cardiovascular risk factors and all-cause mortality after an acute cardiac event. Read More

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Quantification of Flow by 3D Color Flow Doppler:: From Pretty Pictures to Priceless Physiology.

Can J Cardiol 2018 Jun 2;34(6):703-704. Epub 2018 May 2.

Marcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia. Electronic address:

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Drip-and-Ship vs Watchful Waiting: What Should Be the Optimal Approach After Fibrinolytic Therapy for Myocardial Infarction With ST-Segment Elevation?

Can J Cardiol 2018 Jun 3;34(6):700-702. Epub 2018 Apr 3.

Division of Cardiology, McGill Health University Center, Montréal, Québec, Canada. Electronic address:

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Quality of Cardiac Care in Canada: Recommendations for Building a Sustainable Future.

Can J Cardiol 2018 Jun 31;34(6):800-803. Epub 2018 Jan 31.

University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Cardiovascular (CV) disease continues to present a significant disease and economic burden in Canada. To improve the quality of care and ensure sustainability of services, a national quality improvement initiative is required. The purpose of this analysis was to review the evidence for public reporting (PR) and external benchmarking (EB) to improve patient outcomes, and to recommend a strategy to improve CV care in Canada. Read More

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June 2018
1 Read