6,179 results match your criteria Canadian Journal of Cardiology[Journal]


Functional Dosage of Muscarinic Cholinergic Receptor 3 Signalling, Not the Gene Dose, Determines Its Hypertension Pathogenesis.

Can J Cardiol 2018 Dec 28. Epub 2018 Dec 28.

Department of Medicine, Research Centre, Centre hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.

Background: Multiple quantitative trait loci for blood pressure (BP) have been localized throughout human and rodent genomes. Few of them have been functionally identified especially in humans, and little is known about their pathogenic directionality when identified. We focused on Chrm3 encoding the muscarinic cholinergic receptor 3 (M3R) as the causal gene for C17QTL1 in the Dahl salt-sensitive rat model. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.029DOI Listing
December 2018

Prothrombotic State in Atrial Fibrillation Patients With One Additional Risk Factor of the CHADS-VASc Score (Beyond Sex).

Can J Cardiol 2019 Jan 30. Epub 2019 Jan 30.

Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Background: It is unclear whether a prothrombotic state occurs in atrial fibrillation (AF) with low stroke risk.

Methods: We studied 118 patients with AF with the Congestive Heart Failure, Hypertension, Age (≥ 75 years), Diabetes, Stroke/Transient Ischemic Attack/Systemic Embolism, Vascular Disease, Age (65-74 years), Sex (Female) (CHADS-VASc) score of 1 in men or 2 in women vs 52 patients with AF with the CHADS-VASc score of 0 in men or 1 in women. Plasma clot permeability (K), a measure of fibrin clot density, and clot lysis time (CLT), endogenous thrombin potential (ETP), von Willebrand factor antigen, and plasminogen activator inhibitor-1 were evaluated in nonanticoagulated subjects. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.014DOI Listing
January 2019
4 Reads

Muscarinic Receptor Type-3 in Hypertension and Cholinergic-Adrenergic Crosstalk: Genetic Insights and Potential for New Antihypertensive Targets.

Can J Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2019.02.003DOI Listing
February 2019

Sinus Venosus Interatrial Communication, Anomalous Pulmonary Venous Return, Pulmonary Artery Aneurysm With Left Main Compression: Complex Case With Complex Management.

Can J Cardiol 2019 Apr 29;35(4):544.e7-544.e9. Epub 2018 Dec 29.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; Center for Pulmonary Hypertension and Pulmonary Vascular Disease, School of Medicine and the Affiliated Hospital, China Medical University, Taichung, Taiwan. Electronic address:

A young female patient was referred for pulmonary arterial hypertension (PAH). Catheterization revealed a large sinus venosus interatrial communication (SVIAC), partial anomalous pulmonary venous return (PAPVR), pulmonary vascular resistance (PVR) 15 Wood units, and bidirectional shunting. She was then put on target medication for PAH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183140
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http://dx.doi.org/10.1016/j.cjca.2018.12.030DOI Listing
April 2019
10 Reads

Neonatal Cardiac Arrest From Left Ventricular Cardiac Hemangioma: A Surprising Presentation.

Can J Cardiol 2019 Apr 13;35(4):544.e3-544.e5. Epub 2019 Feb 13.

Services de Chirurgie Cardiovasculaire Pédiatrique, Québec-Université Laval, Quebec City, Quebec, Canada.

Cardiac hemangioma is rare, even more when leading to a cardiovascular collapse in a seemingly healthy newborn. A 6-day-old neonate had a tamponade caused by a basolateral hemangioma of the left ventricle. Partial surgical resection was performed. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.023DOI Listing
April 2019
4 Reads

Possible Transmitral Pressure Gradient Elevation in MitraClip XTR.

Can J Cardiol 2019 Apr 13;35(4):544.e15-544.e17. Epub 2019 Feb 13.

University Heart Center Zürich, Zürich, Switzerland.

A 74-year-old man presented with dyspnea due to severe mitral regurgitation (MR) caused by rupture of the chordae tendineae. Percutaneous edge-to-edge mitral valve repair was performed using the MitraClip system (Abbott Vascular, Santa Clara, CA). After leaflet grasping via an XTR clip, transesophageal echocardiography (TEE) revealed marked reduction of MR, but elevation of the transmitral gradient was detected no matter how the position of grasping was changed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X193010
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http://dx.doi.org/10.1016/j.cjca.2019.01.024DOI Listing
April 2019
8 Reads

Successful Localization and Removal of an Aberrant Sewing Needle in the Posterior Mediastinum: Usefulness of Multidetector Computed Tomography.

Can J Cardiol 2019 Apr 30;35(4):544.e11-544.e13. Epub 2019 Jan 30.

Department of Cardiovascular Surgery, Amagasaki General Medical Center, Amagasaki, Japan.

Foreign metallic bodies in the mediastinum are relatively rare and may cause life-threatening damages to multiple organs in the mediastinum; therefore, the foreign body warrants urgent or elective removal. When the foreign body remains in the posterior mediastinum surrounded by important organs, for example, the heart or the great vessels, it is critical to determine the right approach for its safe removal. Here, we present the successful removal of a sewing needle from the posterior mediastinum using multidetector computed tomography that helped identify the foreign body's location and its relationship with the surrounding organs. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.012DOI Listing

Reversible Cabozantinib-Induced Cardiomyopathy.

Can J Cardiol 2019 Apr 29;35(4):544.e1-544.e2. Epub 2018 Dec 29.

The Division of Cardiology, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada; The Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address:

Cabozantinib is a multitargeted tyrosine kinase inhibitor, with activity against vascular endothelial growth factor receptor, as well as MET, RET, and AXL. It is currently approved for treating advanced thyroid and kidney cancers, and is being investigated in other cancers. We present a case of reversible heart failure due to cabozantinib use in a 70-year-old man with metastatic renal cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.025DOI Listing
April 2019
3 Reads

Switching Between β-Blockers: An Empiric Tool for the Cardiovascular Practitioner.

Can J Cardiol 2019 Apr 31;35(4):539-543. Epub 2019 Jan 31.

Division of Cardiology, St Paul's Hospital and Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

β-Blockers are a cornerstone of therapy for cardiovascular disease, but their clinical benefits are not consistent across the class and specific agents are preferred for certain indications. Further, when prescribed, a patient's clinical status might change, requiring the cardiologist to switch to an alternate agent. Examples of such scenarios include the development or a worsening of chronic noncardiac diseases (eg, hyperthyroidism, renal failure), new cardiac-related disease (eg, heart failure, atrial fibrillation), or practical/safety issues (eg, pregnancy, cost, side effects). Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.013DOI Listing
April 2019
3 Reads

Ionizing Radiation in Interventional Cardiology and Electrophysiology.

Can J Cardiol 2019 Apr 25;35(4):535-538. Epub 2019 Jan 25.

McGill University Health Center, Division of Cardiology, Montréal, Québec, Canada; Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Division of Cardiology, Jewish General Hospital/McGill University, Montréal, Québec, Canada.

Fluoroscopy-guided procedures constitute a major part in the practice of cardiology. These procedures are also a source of human-made ionizing radiation. Although the benefits of performing the procedure surpass the radiogenic risks in most cases, the risks are not negligible. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.006DOI Listing
April 2019
4 Reads

Evaluation of Cardiac Recovery in Ventricular Assist Device Recipients: Particularities, Reliability, and Practical Challenges.

Can J Cardiol 2019 Apr 29;35(4):523-534. Epub 2018 Nov 29.

Deutsches Herzzentrum, Berlin, Germany; Cardio Centrum, Berlin, Germany.

In carefully selected patients with ventricular assist devices (VADs), good long-term results after device weaning and explantation can be achieved when reverse remodelling and improvement of native cardiac function occur. Monitoring of cardiac size, geometry, and function after initial VAD implantation is necessary to identify such patients. Formal guidelines for recovery assessment in patients with VADs do not exist, and protocols for recovery assessment and criteria for device weaning and explantation vary among centres. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.015DOI Listing

Impaired Adrenergic/Protein Kinase A Response of Slow Delayed Rectifier Potassium Channels as a Long QT Syndrome Motif: Importance and Unknowns.

Can J Cardiol 2019 Apr 24;35(4):511-522. Epub 2018 Nov 24.

Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address:

The slow delayed rectifier potassium current (I) significantly contributes to cardiac repolarization under specific conditions, particularly at stimulation by the protein kinase A (PKA) during increased sympathetic tone. Impaired PKA-mediated stimulation of I channels may considerably aggravate dysfunction of the channels induced by mutations in the KCNQ1 gene that encodes the structure of the α-subunit of I channels. These mutations are associated with several subtypes of inherited arrhythmias, mainly long QT syndrome type 1, less commonly short QT syndrome type 2, and atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.012DOI Listing

The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Postconditioning.

Can J Cardiol 2019 Apr 18;35(4):501-510. Epub 2019 Jan 18.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Remote ischemic postconditioning (RIPostC) could reduce myocardial ischemia/reperfusion injury markedly. However, the mechanism of the protective signal transfer of RIPostC to the heart remains unclear. In this study, we hypothesize that macrophage migration inhibitory factor (MIF) plays an important role in the cardioprotection conferred by RIPostC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X193003
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http://dx.doi.org/10.1016/j.cjca.2018.12.040DOI Listing
April 2019
5 Reads

Macrophage-Specific IκB Kinase α Contributes to Ventricular Remodelling and Dysfunction After Myocardial Infarction.

Can J Cardiol 2019 Apr 19;35(4):490-500. Epub 2019 Jan 19.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:

Background: The IκB kinase (IKK) complex has been found to have critical functions in cancer and the immune system. In particular, IKKα, which is a member of the IKK complex, has been shown to influence the inflammatory response and malignant diseases. However, the role of IKKα in macrophages after myocardial infarction (MI) remains largely unknown. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.002DOI Listing
April 2019
4 Reads

Involvement of lncR-30245 in Myocardial Infarction-Induced Cardiac Fibrosis Through Peroxisome Proliferator-Activated Receptor-γ-Mediated Connective Tissue Growth Factor Signalling Pathway.

Can J Cardiol 2019 Apr 16;35(4):480-489. Epub 2019 Feb 16.

Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, P. R. China; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, P. R. China. Electronic address:

Background: Long noncoding RNAs (lncRNAs) are emerging as important mediators of cardiac pathophysiology. The aim of the present study is to investigate the effects of lncR-30245, an lncRNA, on cardiac fibrogenesis and the underlying mechanism.

Methods: Myocardial infarction (MI) and transforming growth factor (TGF)-β1 were used to induce fibrotic phenotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X193011
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http://dx.doi.org/10.1016/j.cjca.2019.02.005DOI Listing
April 2019
5 Reads

Ensembling Electrical and Proteogenomics Biomarkers for Improved Prediction of Cardiac-Related 3-Month Hospitalizations: A Pilot Study.

Can J Cardiol 2019 Apr 4;35(4):471-479. Epub 2019 Jan 4.

Centre of Excellence for Prevention of Organ Failure, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Background: Many risk models for predicting mortality, hospitalizations, or both in patients with heart failure have been developed but do not have sufficient discriminatory ability. The purpose of this study was to identify predictive biomarkers of hospitalizations in heart failure patients using omics-based technologies applied to blood and electrical monitoring of the heart.

Methods: Blood samples were collected from 58 heart failure patients during enrollment into this study. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.039DOI Listing
April 2019
1 Read

The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.

Can J Cardiol 2019 Apr 26;35(4):462-470. Epub 2018 Dec 26.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Growth differentiation factor-15 (GDF-15) is a stress-inducible cytokine and member of the transforming growth factor-β cytokine superfamily that refines prognostic assessment in subgroups of patients with heart failure (HF). We evaluated its role in HF patients with chronic kidney disease (CKD, estimated glomerular filtration rate <60 mL/min/1.73 m). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.027DOI Listing
April 2019
1 Read

Improving Prenatal Diagnosis of Coarctation of the Aorta.

Can J Cardiol 2019 Apr 17;35(4):453-461. Epub 2018 Dec 17.

Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Background: The purpose of the study was to evaluate the association between fetal echocardiographic measurements and the need for intervention (primary coarctation repair, staged coarctation repair, or catheter intervention) in prenatally diagnosed coarctation of the aorta.

Methods: A single-centre retrospective cohort study (2005-2015) of 107 fetuses diagnosed with suspected coarctation of the aorta in the setting of an apex-forming left ventricle and antegrade flow across the mitral and aortic valves.

Results: Median gestational age at diagnosis was 32 weeks (interquartile range, 23-35 weeks). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.019DOI Listing
April 2019
4 Reads

Contemporary Outcomes and Factors Associated With Mortality After a Fetal or Postnatal Diagnosis of Common Arterial Trunk.

Can J Cardiol 2019 Apr 11;35(4):446-452. Epub 2018 Dec 11.

Divisions of Cardiology and Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Common arterial trunk (CAT) is a rare anomaly with a spectrum of pathology. We sought to identify current trends and factors associated with postnatal outcomes.

Methods: This was a single-centre review including 153 live births with planned surgery. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.006DOI Listing
April 2019
1 Read

The Natural and Unnatural History of Congenital Aortic Arch Abnormalities Evaluated in an Adult Survival Cohort.

Can J Cardiol 2019 Apr 7;35(4):438-445. Epub 2018 Dec 7.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Background: This study describes the different types of congenital vascular rings according to their anatomy, symptoms, and age at clinical onset and reports the surgical outcomes.

Methods: A retrospective observational database study was conducted, reviewing the medical charts of 69 adult survivors with a history of a vascular ring, identified from the Dutch Congenital Cor vitia database.

Results: Median age at presentation was 8. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.004DOI Listing
April 2019
2 Reads

Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial.

Can J Cardiol 2019 Apr 31;35(4):430-437. Epub 2018 Dec 31.

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: The effect of sex on self-reported frailty in acute coronary syndromes (ACS) is unclear. We examined the prevalence of self-reported frailty and its association with all-cause death among men and women.

Methods: Elderly (≥ 65 years) male (n = 2691) and female (n = 2305) patients with ACS enrolled in the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial were screened using the Fried Frailty Index. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183141
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http://dx.doi.org/10.1016/j.cjca.2018.12.035DOI Listing
April 2019
3 Reads

Pulmonary Artery Elastic Properties After Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension.

Can J Cardiol 2019 Apr 2;35(4):422-429. Epub 2019 Feb 2.

Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College at John Paul II Hospital, Krakow, Poland. Electronic address:

Background: A significant proportion of the right ventricular afterload is determined by the elastic properties of the pulmonary artery (PA). We aimed to assess the effect of balloon pulmonary angioplasty (BPA) on PA elastic properties in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH).

Methods: We enrolled adult patients with CTEPH treated with BPA and controls without PH. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.016DOI Listing
April 2019
1 Read

Peridevice Leak After Left Atrial Appendage Closure: Incidence, Risk Factors, and Clinical Impact.

Can J Cardiol 2019 Apr 21;35(4):405-412. Epub 2018 Dec 21.

Cardiology Department, Expert Valve Center, Henri Mondor Hospital, Créteil, France. Electronic address:

Background: Limited studies reported the rate and clinical impact of peridevice leaks (PDL) after percutaneous left atrial appendage closure (LAAC).

Methods: All consecutive patients with a nonvalvular atrial fibrillation admitted for LAAC between November 2011 and October 2016 were prospectively enrolled. The follow-up included clinical, transesophageal echocardiography, and/or cardiac computed tomography angiogram (CCTA). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.022DOI Listing
April 2019
1 Read

A Very Long-term Longitudinal Study on the Evolution and Clinical Outcomes of Persistent Iatrogenic Atrial Septal Defect After Cryoballoon Ablation.

Can J Cardiol 2019 Apr 26;35(4):396-404. Epub 2018 Dec 26.

Princess Margaret Hospital, Kowloon, Hong Kong.

Background: Persistent iatrogenic atrial septal defect (iASD) is a common but poorly characterized complication after cryoballoon (CB) pulmonary vein isolation (PVI) procedures. We therefore investigate its prevalence, evolution, risk factors, and clinical outcomes in a prospective longitudinal study.

Methods: A total of 108 patients (41 women, mean age 57 ± 11. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.028DOI Listing
April 2019
2 Reads

The Effect of Cardiac Rehabilitation and a Specialized Clinic on Outcomes of Patients With Atrial Fibrillation.

Can J Cardiol 2019 Apr 14;35(4):382-388. Epub 2018 Dec 14.

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada. Electronic address:

Background: Cardiac rehabilitation (CR) intervention programs are currently not part of management in patients with atrial fibrillation (AF). We sought to determine the effect of CR compared with a specialized AF clinic (AFC) and usual care on outcomes in patients with AF.

Methods: This was a single-centre retrospective cohort study that was carried out using 3 databases: the Hearts in Motion database (2010-2014), prospectively collected data in an AFC (2011-2014), and a retrospective chart review for patients in usual care (2009-2012). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.013DOI Listing
April 2019
1 Read

Next-Generation Approaches to Predicting the Need for Heart Failure Hospitalization.

Can J Cardiol 2019 Apr 25;35(4):379-381. Epub 2019 Jan 25.

University of Toronto, Toronto, Ontario, Canada; Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2019.01.008DOI Listing
April 2019
1 Read

Truncus Arteriosus: An Updated Benchmark for Clinical Management of an Important Congenital Cardiac Malformation.

Can J Cardiol 2019 Apr 31;35(4):376-378. Epub 2018 Dec 31.

Children's Health Dallas, University of Texas Southwestern, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/j.cjca.2018.12.036DOI Listing
April 2019
1 Read

Congenital Aortic Arch Anomalies: Lessons Learned and to Learn!

Can J Cardiol 2019 Apr 30;35(4):373-375. Epub 2019 Jan 30.

Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, and University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2019.01.011DOI Listing
April 2019
1 Read

Role and Assessment of Peri-Device Leaks After Left Atrial Appendage Occlusion.

Can J Cardiol 2019 Apr 31;35(4):370-372. Epub 2019 Jan 31.

Hospital Clinic de Barcelona, Institut Clinic Cardiovascular, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.cjca.2019.01.015DOI Listing
April 2019
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Iatrogenic Atrial Septal Defects After Transseptal Access for Atrial Fibrillation Ablations.

Can J Cardiol 2019 Apr 25;35(4):368-369. Epub 2019 Jan 25.

Schulich Heart Center, Sunnybrook Hospital, University of Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2019.01.007DOI Listing
April 2019
2 Reads

Impact of Chronic Kidney Disease on Decision Making and Management in Transcatheter Aortic Valve Interventions.

Can J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Centre for Heart Valve Innovation, St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

The coexistence of chronic kidney disease (CKD) and severe aortic stenosis (AS) is common, and the prevalence of both is rising. The 2 conditions are inherently linked in that significant CKD may accelerate the development of AS and severe AS may result in deteriorating kidney function. The volume of and indications for transcatheter aortic valve implantation (TAVI) procedures are ever-increasing, and there are many challenges that need to be considered in patients with concomitant severe AS and CKD being assessed for TAVI. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.010DOI Listing
November 2018
2 Reads

Sex-Specific Considerations in Guidelines Generation and Application.

Can J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

New knowledge about male-female differences in pathophysiology, diagnosis, and treatment is shifting the practice of medicine from a one-size-fits all approach to a more individualized process that considers sex-specific interventions at the point of care. In this article, we review how clinical practice guideline committees can incorporate a structured framework to determine whether sex-specific assessments of the quality of the evidence or the particular recommendations should be made. The process can be operationalized by societies who author clinical practice guidelines by developing formal policies to approach biological sex in a systematic way, and by ensuring that writing committees include an individual who will champion the formal appraisal of the literature for associations between sex and the outcomes of interest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183128
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http://dx.doi.org/10.1016/j.cjca.2018.11.011DOI Listing
November 2018
6 Reads

The Relationship Between Heart-Failure Hospitalization and Mortality in Patients Receiving Transcatheter Aortic Valve Replacement.

Can J Cardiol 2019 Apr 28;35(4):413-421. Epub 2018 Nov 28.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Background: Patients who have had transcatheter aortic valve replacement (TAVR) are at risk of hospitalization during the first year postprocedure. Few studies have examined the incidence of heart- failure hospitalizations (HFH) post-TAVR and the impact this has on subsequent hospitalizations and mortality. Our aim was to determine the incidence, predictors, and mortality associated with HFH post-TAVR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183130
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http://dx.doi.org/10.1016/j.cjca.2018.11.016DOI Listing
April 2019
2 Reads

Prospective Study of Tricuspid Regurgitation Associated With Permanent Leads After Cardiac Rhythm Device Implantation.

Can J Cardiol 2019 Apr 29;35(4):389-395. Epub 2018 Nov 29.

Department of Cardiology, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: Tricuspid regurgitation (TR) has been associated with cardiac rhythm device (CRD) implantation with intracardiac lead insertion. However, data on the incidence of postdevice TR are limited and largely from retrospective studies. We hypothesized that permanent lead implantation would be associated with an increase in TR. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.014DOI Listing

The Effect of Cardiac Rehabilitation on Health-Related Quality of Life in Patients With Coronary Artery Disease: A Meta-analysis.

Can J Cardiol 2019 Mar 24;35(3):352-364. Epub 2018 Nov 24.

Toronto Health Economics and Technology Assessment (THETA) Collaborative, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: The clinical effectiveness of cardiac rehabilitation (CR) on health-related quality of life (HRQOL) is an area that has not been consistently explored. The objective of this systematic review was to evaluate the effectiveness of providing any core component of CR on HRQOL domains.

Methods: We performed a meta-analysis and meta-regression of randomized controlled trials (RCTs) on the core components of CR. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.013DOI Listing
March 2019
2 Reads

Comparison of Readmission and Death Among Patients With Cardiac Disease in Northern vs Southern Ontario.

Can J Cardiol 2019 Mar;35(3):341-351

Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada; ICES, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Geographic factors may influence cardiovascular disease outcomes in Canada. Circulatory diseases are a major reason for higher population mortality rates in Northern Ontario, but it is unknown if hospitalized patients with cardiovascular disease experience differential outcomes compared with those in the South.

Methods: We examined 30-day and 1-year mortality and readmissions for patients hospitalized with acute myocardial infarction (AMI), heart failure (HF), atrial fibrillation (AF), or stroke in Northern compared with Southern Ontario, using the Canadian Institute for Health Information Discharge Abstract Database (2005-2016). Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.004DOI Listing
March 2019
3 Reads

Getting to the Heart of the Matter: A Review of Drug Interactions Between HIV Antiretrovirals and Cardiology Medications.

Can J Cardiol 2019 Mar 19;35(3):326-340. Epub 2018 Dec 19.

Faculty of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

The past 20 years have seen remarkable advances in the treatment of HIV such that most people diagnosed with HIV today can live long, healthy lives by taking antiretrovirals which are usually life-long. Advancements in antiretroviral therapy include the availability of well tolerated, single tablet regimens that are associated with a lower risk of drug-drug interactions. Despite this, many people living with HIV infection might be taking antiretroviral agents that are associated with significant drug-drug interactions. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.020DOI Listing
March 2019
3 Reads

Mechanisms of Arrhythmia and Sudden Cardiac Death in Patients With HIV Infection.

Can J Cardiol 2019 Mar 15;35(3):310-319. Epub 2018 Dec 15.

Research Center, Montreal Heart Institute, Montréal, Québec, Canada; Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Long-term survival of HIV-infected patients has significantly improved with the use of antiretroviral therapy (ART). As a consequence, cardiovascular diseases are now emerging as an important clinical problem in this population. Sudden cardiac death is the third leading cause of mortality in HIV patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183137
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http://dx.doi.org/10.1016/j.cjca.2018.12.015DOI Listing
March 2019
8 Reads

Pulmonary Hypertension in HIV.

Can J Cardiol 2019 Mar;35(3):288-298

MedStar Heart and Vascular Institute, Washington Hospital Center, Washington, DC, USA; MedStar Georgetown University Hospital, Washington, DC, USA. Electronic address:

Human immunodeficiency virus-associated pulmonary arterial hypertension (HIV-PAH) is important to recognize given its association with significant morbidity and mortality. With the introduction of antiretroviral therapy, the focus of disease management has largely shifted from treating immunodeficiency-related opportunistic infections to managing chronic cardiopulmonary complications. Symptoms are nonspecific, and a high index of clinical suspicion is needed to avoid significant delay in the diagnosis of HIV-PAH. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.005DOI Listing
March 2019
2 Reads

Stroke in HIV.

Can J Cardiol 2019 Mar 6;35(3):280-287. Epub 2018 Dec 6.

Divisions of Infectious Diseases and General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Stroke is a heterogeneous disease in persons living with human immunodeficiency virus (HIV). HIV is thought to increase the risk of stroke through both HIV-related and traditional stroke risk factors, which vary with respect to the patient's age and clinical characteristics. Numerous studies show that detectable viremia and immunosuppression increase the risk of stroke across all ages, whereas traditional risk factors are more common in the aging population with HIV. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400325PMC
March 2019
2 Reads

Coronary Artery Disease Manifestations in HIV: What, How, and Why.

Can J Cardiol 2019 Mar 4;35(3):270-279. Epub 2018 Dec 4.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

Understanding why persons with human immunodeficiency virus (HIV) have accelerated atherosclerosis and its sequelae, including coronary artery disease (CAD) and myocardial infarction, is necessary to provide appropriate care to a large and aging population with HIV. In this review, we delineate the diverse pathophysiologies underlying HIV-associated CAD and discuss how these are implicated in the clinical manifestations of CAD among persons with HIV. Several factors contribute to HIV-associated CAD, with chronic inflammation and immune activation likely representing the primary drivers. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.029DOI Listing
March 2019
4 Reads

Noninvasive Cardiovascular Imaging: Emergence of a Powerful Tool for Early Identification of Cardiovascular Risk in People Living With HIV.

Can J Cardiol 2019 Mar 18;35(3):260-269. Epub 2018 Dec 18.

Fiona Stanley Hospital, Murdoch, Western Australia, Australia; Harry Perkins Institute of Medical Research, Murdoch, Western Australia, Australia; The University of Western Australia, Crawley, Western Australia, Australia. Electronic address:

Antiretroviral therapy (ART) has been pivotal in prolonging the lifespan of people living with HIV (PLWH). However, this also simultaneously increases their risk of cardiovascular disease (CVD) either related to ART, aging, hypertension, immunosenescence, inflammation, immune activation, or other comorbidities. Although the use of risk markers has greatly enhanced the field of cardiovascular (CV) medicine and improved the prognosis and early diagnosis in the general population, this strategy has not been clearly elucidated in PLWH. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.036DOI Listing

Mechanisms of Cardiovascular Disease in the Setting of HIV Infection.

Authors:
Priscilla Y Hsue

Can J Cardiol 2019 Mar 29;35(3):238-248. Epub 2018 Dec 29.

University of California San Francisco (UCSF), Zuckerberg San Francisco General Hospital, San Francisco, California, USA. Electronic address:

Although the initial reports of increased cardiovascular (CV) disease in the setting of advanced AIDS were reported approximately 30 years ago, advances in antiretroviral therapy and immediate initiation of therapy on diagnosis have transformed what was once a deadly infectious disease into a chronic health condition. Accordingly, the types of CV diseases occurring in HIV have shifted from pericardial effusions and dilated cardiomyopathy to atherosclerosis and heart failure. The underlying pathophysiology of HIV-associated CV disease remains poorly understood, partly because of the rapidly evolving nature of HIV treatment and because clinical endpoints take many years to develop. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.024DOI Listing
March 2019
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Adding Life to Years in Cardiac Rehabilitation: Importance of Measuring Quality of Life.

Can J Cardiol 2019 Mar 14;35(3):235-237. Epub 2018 Dec 14.

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada; University Health Network/Toronto Rehabilitation Institute, Cardiovascular Prevention and Rehabilitation Program, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183137
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http://dx.doi.org/10.1016/j.cjca.2018.12.018DOI Listing
March 2019
4 Reads
3.711 Impact Factor