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    5784 results match your criteria Canadian Journal of Cardiology[Journal]

    1 OF 116

    Blood Pressure-Lowering Targets in Patients With Diabetes Mellitus.
    Can J Cardiol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    Diabetes is a highly prevalent medical condition that commonly coexists with hypertension. The presence of diabetes and hypertension significantly increases the risk of adverse cardiovascular events. Although compelling evidence exists from randomized controlled trials demonstrating that blood pressure (BP) reduction effectively prevents cardiovascular complications, optimal BP targets remain uncertain and continue to be the subject of ongoing controversy. Read More

    Shared Decision-Making as the Future of Emergency Cardiology.
    Can J Cardiol 2017 Sep 22. Epub 2017 Sep 22.
    Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, USA; Division of Healthcare Policy and Research, Mayo Clinic, Rochester, Minnesota, USA; Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    Shared decision-making is playing an increasingly large role in emergency cardiovascular care. Although there are many challenges to successfully performing shared decision-making in the emergency department, there are numerous clinical scenarios in which it should be used. In this article, we explore new research and emerging decision aids in the following emergency care scenarios: (1) low-risk chest pain; (2) new-onset atrial fibrillation; and (3) moderate-risk syncope. Read More

    Prediction of Early Adverse Events in Emergency Department Patients With Acute Heart Failure: A Systematic Review.
    Can J Cardiol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Emergency Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Background: Acute heart failure (AHF) accounts for a substantial proportion of Emergency Department (ED) visits and hospitalizations. Previous studies have shown that emergency physicians' clinical gestalt is not sufficient to stratify patients with AHF into severe and requiring hospitalization vs nonsevere and safe to be discharged. Various prognostic algorithms have been developed to risk-stratify patients with AHF, however there is no consensus as to the best-performing risk assessment tool in the ED. Read More

    Novel Biomarkers for Predicting Cardiovascular Disease in Patients With Diabetes.
    Can J Cardiol 2017 Oct 31. Epub 2017 Oct 31.
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:
    It is generally acknowledged that patients with diabetes comprise a high-risk population for the development of cardiovascular disease. However, it is perhaps less well recognized that there actually exists considerable heterogeneity in vascular risk within this patient population, with a sizable subset of individuals seemingly at low risk for major cardiovascular events despite the presence of diabetes. Because traditional clinical risk calculators have shown wide variability in their performance in the setting of diabetes, there exists a need for additional risk predictors in this patient population. Read More

    Does Early Coronary Angiography Improve Survival After out-of-Hospital Cardiac Arrest? A Systematic Review With Meta-Analysis.
    Can J Cardiol 2017 Sep 18. Epub 2017 Sep 18.
    Emergency Medicine Residency Program, McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, McMaster University, Hamilton, Ontario, Canada.
    Background: In patients with out-of-hospital cardiac arrest who achieve return of spontaneous circulation, coronary angiography (CAG) might improve outcomes. We conducted a systematic review and meta-analysis to elucidate the benefit and optimal timing of early CAG in comatose out-of-hospital cardiac arrest patients with return of spontaneous circulation.

    Methods: We searched MEDLINE, EMBASE, and Cochrane from 1990 to May 2017. Read More

    Transradial-Guided Percutaneous Transaxillary Intra-aortic Balloon Pump Insertion.
    Can J Cardiol 2018 Jan 16;34(1):92.e5-92.e7. Epub 2017 Oct 16.
    Division of Cardiology, Department of Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada. Electronic address:
    Axillary access for an intra-aortic balloon pump allows patients with advanced heart failure (HF) to sit upright and ambulate while waiting for destination therapy or bridging to heart transplantation. We describe the combination of radial access for positioning a 4F pigtail catheter to allow axillary angiography and provide a target for a micropuncture needle entry point in a fully anticoagulated patient with advanced HF. Read More

    Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists.
    Can J Cardiol 2018 Jan 16;34(1):92.e1-92.e3. Epub 2017 Oct 16.
    Department of Oncology, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
    The ever-increasing use of immune checkpoint inhibitors in cancer is leading to a high incidence of autoimmune side effects. This report discusses an autoimmune fulminant myocarditis in an elderly patient with metastatic pulmonary adenocarcinoma in whom the most advanced invasive heart failure therapies were used successfully. She was treated with nivolumab. Read More

    Avoiding Clinical Errors With Bedside Echocardiography: A Randomized Clinical Study.
    Can J Cardiol 2018 Jan 31;34(1):88-91. Epub 2017 Oct 31.
    Division of Medicine, Department of Cardiology, McMaster University, Hamilton, Ontario, Canada; The Centre for Excellence in Education and Practice (CEEP), Toronto, Ontario, Canada. Electronic address:
    Clinicians have strong opinions about whether they should be provided the clinical history before or after bedside testing. We hypothesized that diagnostic accuracy is improved when a concordant clinical history is provided before a diagnostic test. To investigate whether the timing (before or after) and the consistency (concordant vs discordant) of the clinical history in the setting of focused bedside echocardiography affects clinician diagnostic accuracy and management decisions. Read More

    Subclinical Hypothyroidism Is Associated With Adverse Prognosis in Heart Failure Patients.
    Can J Cardiol 2018 Jan 8;34(1):80-87. Epub 2017 Nov 8.
    Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
    Background: It is widely recognized that overt hyper- as well as hypothyroidism are potential causes of heart failure (HF). Additionally it has been recently reported that subclinical hypothyroidism (sub-hypo) is associated with atherosclerosis, development of HF, and cardiovascular death. We aimed to clarify the effect of sub-hypo on prognosis of HF, and underlying hemodynamics and exercise capacity. Read More

    The Extent of Left Atrial Low-Voltage Areas Included in Pulmonary Vein Isolation Is Associated With Freedom from Recurrent Atrial Arrhythmia.
    Can J Cardiol 2018 Jan 19;34(1):73-79. Epub 2017 Oct 19.
    Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:
    Background: The extent of left atrial (LA) baseline low-voltage areas (LVA-B), which may be a surrogate for fibrosis, is associated with recurrent atrial fibrillation (AF) after ablation. This study aimed to assess the relationship between the extent of LVA-B isolated by ablation (LVA-I) and AF recurrence.

    Methods: The study cohort included 159 consecutive patients with drug-refractory AF who underwent an initial AF ablation with LA voltage mapping during sinus rhythm. Read More

    Dynamic QT Interval Changes from Supine to Standing in Healthy Children.
    Can J Cardiol 2018 Jan 28;34(1):66-72. Epub 2017 Oct 28.
    Division of Cardiology, CHU mère-enfant Sainte-Justine, Université de Montréal, Montréal, Québec, Canada; Electrophysiology Service and Adult Congenital Heart Center, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada. Electronic address:
    Background: QT-interval variations in response to exercise-induced increases in heart rate have been reported in children and adults in the diagnosis of long QT syndrome (LQTS). A quick standing challenge has been proposed as an alternative provocative test in adults, with no pediatric data yet available.

    Methods: A standing test was performed in 100 healthy children (mean age, 9. Read More

    Health Care Use and Associated Time and Out of Pocket Expenditures for Patients With Cardiovascular Disease in a Publicly Funded Health Care System.
    Can J Cardiol 2018 Jan 7;34(1):52-60. Epub 2017 Oct 7.
    Department of Kinesiology and Health Science, York University, Toronto, Ontario, Canada; Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: The objectives of this study were to describe (1) health care use and associated patient time and out of pocket (OOP) costs over 2 years after a cardiac diagnosis, (2) the sociodemographic and clinical drivers of these costs, and (3) patient costs related to cardiac rehabilitation (CR) participation.

    Methods: Secondary analysis was conducted in an observational prospective CR program evaluation cohort in Ontario, which has a publicly funded health care system. A convenience sample of patients from 1 of 3 CR programs was approached at the first visit, and consenting participants completed a survey. Read More

    Dysfunctional Uterine Activity in Labour and Premature Adverse Cardiac Events: Population-Based Cohort Study.
    Can J Cardiol 2018 Jan 16;34(1):45-51. Epub 2017 Oct 16.
    Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: There exist structural and physiological commonalities between myometrial and myocardial tissue, and each can become dysfunctional, such as in the presence of cardiometabolic factors.

    Methods: This population-based cohort study was comprised of 1,608,720 women with ≥ 1 singleton hospital live birth at 24-41 weeks' gestation in Ontario, from 1992 to 2016. The main exposure was prolonged first stage of labour; secondary exposure was prolonged second stage of labour. Read More

    Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease: A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial.
    Can J Cardiol 2018 Jan;34(1):38-44
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
    Background: It is unclear whether modifying cholesterol, blood pressure, or both affect erectile dysfunction. Also, there are concerns that erectile dysfunction is worsened by common medications used to treat these risk factors. In this study, we evaluated the effect of: (1) cholesterol-lowering with a statin; (2) pharmacologic blood pressure reduction; and (3) their combination, on erectile function. Read More

    Cost-Effectiveness of Different Durations of Dual-Antiplatelet Use After Percutaneous Coronary Intervention.
    Can J Cardiol 2018 Jan 6;34(1):31-37. Epub 2017 Oct 6.
    Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: There is uncertainty regarding the optimal duration of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). Our goal was to evaluate the cost-effectiveness of different durations of DAPT.

    Methods: We created a probabilistic patient-level Markov microsimulation model to assess the discounted lifetime costs and quality-adjusted life years (QALYs) of short duration (3-6 months: short-duration group) vs standard therapy (12 months: standard-duration group) vs prolonged therapy (30-36 months: long-duration group) in patients undergoing PCI. Read More

    Microcatheter-Facilitated Primary Angioplasty in ST-Segment Elevation Myocardial Infarction.
    Can J Cardiol 2018 Jan;34(1):23-30
    Department of Cardiology, Lariboisiere Hospital, Assistance Publique-Hôpitaux de Paris, Paris Diderot University, Paris, France. Electronic address:
    Background: Direct stenting is the best method for achieving reperfusion in primary percutaneous coronary intervention (PPCI). We hypothesized that the use of a microcatheter (MC) during PPCI when Thrombolysis in Myocardial Infarction (TIMI) flow ≤ 1 after wire crossing would allow visualization of the downstream artery with an optimal TIMI 3 flow at the end of the procedure.

    Methods: In this pilot study, PPCI patients with TIMI flow ≤ 1 after wire crossing formed the MC group (n = 60); the MC was positioned in the distal part of the culprit artery and a small amount of contrast was injected through it to determine stent size and length to treat the culprit lesion. Read More

    Effect of Institutional Experience on Outcomes of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy.
    Can J Cardiol 2018 Jan;34(1):16-22
    Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
    Background: The current American College of Cardiology Foundation/American Heart Association guidelines on hypertrophic cardiomyopathy state that institutional experience is a key determinant of successful outcomes and lower complication rates of alcohol septal ablation (ASA). The aim of this study was to evaluate the safety and efficacy of ASA according to institutional experience with the procedure.

    Methods: We retrospectively evaluated 1310 patients with symptomatic obstructive hypertrophic cardiomyopathy who underwent ASA and were divided into 2 groups. Read More

    Contemporary Application of Point-of-Care Echocardiography in the Emergency Department.
    Can J Cardiol 2017 Sep 1. Epub 2017 Sep 1.
    Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
    Point-of-care echocardiography is revolutionizing the management of patients presenting with undifferentiated shock and cardiac arrest in the emergency department (ED). Its primary purpose is to aid the clinician in rapidly ruling in and ruling out life-threatening diagnoses at the bedside. In addition, it has become an important component of the clinical examination for stable patients seen in the ED with nonspecific signs and symptoms such as shortness of breath or syncope. Read More

    Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest: The State of the Evidence and Framework for Application.
    Can J Cardiol 2017 Sep 9. Epub 2017 Sep 9.
    Divisions of Cardiac Surgery and Critical Care Medicine, Western University, London, Ontario, Canada; London Health Sciences Centre, London, Ontario, Canada.
    Out-of-hospital cardiac arrest (OHCA) affects 134 per 100,000 citizens annually. Extracorporeal cardiopulmonary resuscitation (ECPR), providing mechanical circulatory support, may improve the likelihood of survival among those with refractory OHCA. Compared with in-hospital ECPR candidates, those in the out-of-hospital setting tend to be sudden unexpected arrests in younger and healthier patients. Read More

    Comparability of Automated Office Blood Pressure to Daytime 24-Hour Ambulatory Blood Pressure.
    Can J Cardiol 2018 Jan 5;34(1):61-65. Epub 2017 Oct 5.
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Heart Institute, Edmonton, Alberta, Canada. Electronic address:
    Background: Clinical practice guidelines endorse automated office blood pressure (AOBP) measurement as the preferred in-office measurement modality. However, recent data indicate that this method may underestimate daytime ambulatory BP. The objective of this study was to further assess the comparability of mean AOBP and daytime ambulatory BP in clinical practice. Read More

    Pregnancy After Transcatheter Pulmonary Valve Implantation.
    Can J Cardiol 2017 Dec 1;33(12):1737.e5-1737.e7. Epub 2017 Sep 1.
    Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw, Poland.
    Transcatheter pulmonary valve implantation (TPVI) is a relatively new method of treating patients with significant pulmonary regurgitation or pulmonary stenosis, or both, after reconstruction of the right ventricular outflow tract. It is an attractive alternative to conduit replacement in this group of patients, who are typically young and active. This report includes 4 young women who after successful TPVI became pregnant and gave birth. Read More

    Pregnancy in Women With Repaired Truncus Arteriosus: A Case Series.
    Can J Cardiol 2017 Dec 6;33(12):1737.e1-1737.e3. Epub 2017 Oct 6.
    Department of Medicine, Obstetric Medicine and Pregnancy and Heart Disease Programs, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Pregnancy in women with repaired truncus arteriosus (TA) is rare. We report the outcomes of 8 pregnancies in 4 women with surgically repaired TA. None of the women had adverse cardiac events during pregnancy. Read More

    A Case of Spontaneous Coronary Artery Dissection Complicated by Free Wall Rupture.
    Can J Cardiol 2017 Dec 6;33(12):1736.e13-1736.e15. Epub 2017 Oct 6.
    Division of Cardiology, Hamilton General Hospital, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address:
    Spontaneous coronary artery dissection (SCAD) is an unusual and underdiagnosed cause of nonatherosclerotic acute coronary syndrome (ACS). Patients might present in various ways including chest pain, ST-elevation ACS, ventricular arrhythmia, and sudden cardiac death. In a few reports, it manifested initially as cardiac tamponade. Read More

    A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block.
    Can J Cardiol 2017 Dec 22;33(12):1736.e1-1736.e3. Epub 2017 Sep 22.
    Department of Cardiology, Virginia Commonwealth University Health System, Richmond, Virginia, USA.
    This report demonstrates the feasibility of pacing the left bundle branch (LBB) immediately beyond the conduction block to functionally restore the impaired His-Purkinje conduction system in a patient with heart failure and left bundle branch block (LBBB). The pacing required only a low pacing output (0.5 volts/0. Read More

    Endothelial Nitric Oxide Synthase-Induced Hypertrophy and Vascular Dysfunction Contribute to the Left Ventricular Dysfunction in Caveolin-1-/- Mice.
    Can J Cardiol 2017 Dec 25;33(12):1716-1724. Epub 2017 Sep 25.
    Department of Molecular and Experimental Cardiology, TU Dresden, Heart Center Dresden, Dresden, Germany.
    Background: Caveolin-1 (Cav1)-/- mice display impaired development of left ventricular pressure and increased left ventricular wall thickness but no dilated ventricle; these are typical findings in patients with heart failure with preserved ejection fraction (HfpEF). Aiming to clarify if dysfunctional endothelial nitric oxide synthase (eNOS) influences cardiomyocyte contractility, cardiac conduction system, or afterload/vascular resistance, we studied Cav1-/-/eNOS-/- mice.

    Methods: Cardiac function was assessed in vivo by pressure-volume-catheterization of the left ventricle, echocardiography and electrocardiography. Read More

    Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study.
    Can J Cardiol 2017 Dec 12;33(12):1708-1715. Epub 2017 Sep 12.
    RSSC, Papworth Hospital, Papworth Everard, United Kingdom.
    Background: Previous studies have shown a higher prevalence of patent foramen ovale (PFO) in patients with obstructive sleep apnea syndrome (OSAS). Right to left shunting through a PFO may be encouraged by the respiratory physiology of OSAS, contributing to the disease pathophysiology. We assessed whether PFO closure would improve respiratory polygraphy parameters compared with baseline measurements in patients with OSAS. Read More

    The Relationship Between Cardiologist Care and Clinical Outcomes in Patients With New-Onset Atrial Fibrillation.
    Can J Cardiol 2017 Dec;33(12):1693-1700
    Schulich Heart Centre, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
    Background: Increased mortality is well described in patients with atrial fibrillation (AF), primarily related to death from cardiovascular causes. One may hypothesize that cardiology care may be associated with a reduction in cardiovascular deaths in patients with AF, thereby improving their overall survival. The aim of this study was to assess the association between cardiologist care and clinical outcomes, including all-cause mortality, in patients with new-onset AF. Read More

    Clinical Features and Outcomes of Acute Coronary Syndrome in Women With Previous Pregnancy Complications.
    Can J Cardiol 2017 Dec 11;33(12):1683-1692. Epub 2017 Sep 11.
    Research Institute, McGill University Health Centre, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
    Background: Women with previous cardiometabolic complications of pregnancy experience double the risk of cardiovascular disease. However, few data exist on the clinical effect of these complications at the time of an acute coronary syndrome (ACS). The objective of this work was to compare risk factors, clinical features, and outcomes among women with premature ACS with or without previous pregnancy complications (gestational diabetes and/or hypertensive disorders of pregnancy). Read More

    Antiplatelet Effect of Different Loading Doses of Ticagrelor in Patients With Non-ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: The APELOT Trial.
    Can J Cardiol 2017 Dec 12;33(12):1675-1682. Epub 2017 Sep 12.
    Research Institute of Cardiology, General Hospital of Chinese People's Armed Police Forces, Beijing, China.
    Background: We hypothesized that a high ticagrelor loading dose (LD) may improve platelet inhibition in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).

    Methods: This interventional multicentre open-label trial randomized 278 patients with NSTE-ACS to a high (360 mg) or conventional (180 mg) ticagrelor LD. The primary outcome was the platelet reactivity index (PRI) 1 hour after administration of the LD. Read More

    Prognostic Value of Psoas Muscle Area and Density in Patients Who Undergo Cardiovascular Surgery.
    Can J Cardiol 2017 Dec 16;33(12):1652-1659. Epub 2017 Oct 16.
    Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
    Background: Low skeletal muscle density, determined using computed tomography (CT), has yet to be examined in terms of muscle function and prognostic capability in patients who require open cardiovascular surgery. This study was performed to examine whether psoas muscle area and density, determined using CT, are associated with postoperative mortality in patients who undergo cardiovascular surgery.

    Methods: We reviewed the findings in 773 consecutive patients who underwent preoperative CT imaging, including the level of the third lumbar vertebra for clinical purposes. Read More

    The Impact of Burst Exercise on Cardiometabolic Status of Patients Newly Diagnosed With Type 2 Diabetes.
    Can J Cardiol 2017 Dec 6;33(12):1645-1651. Epub 2017 Oct 6.
    Faculty of Pharmacy, Laval University, Québec City, Québec, Canada; Department of Cardiology, Institut de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada. Electronic address:
    Background: The impact of burst high-intensity exercise on physiological, cardiometabolic, and biochemical variables compared with traditional moderate-intensity continuous exercise training (MICT) has yet to be assessed in patients with type 2 diabetes (T2D). We compared the impact of multiple short-duration, high-intensity burst exercise sessions to MICT on cardiometabolic variables in patients with T2D.

    Methods: Forty newly diagnosed patients with T2D not receiving lipid lowering or hypoglycemic medications were randomized to 40 minutes of MICT (60% of maximal heart rate) 5 days per week or 3 continuous bursts of 12 minutes of high-intensity exercise (85% of maximal heart rate) 5 days per week for 3 months. Read More

    Comparison of Different Automated Office Blood Pressure Measurement Devices: Evidence of Nonequivalence and Clinical Implications.
    Can J Cardiol 2017 Dec 15;33(12):1639-1644. Epub 2017 Sep 15.
    Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada. Electronic address:
    Background: Automated office blood pressure (AOBP) measuring devices are increasingly recommended as preferred blood pressure (BP) diagnostic tools, but it is unclear how they compare and how clinical environments impact their performance.

    Methods: This prospective randomized factorial parallel 4-group study compared BP estimates by BpTRU (VSM MedTech, Vancouver, BC, Canada) and Omron HEM 907 (Omron Healthcare, Kyoto, Japan) devices in closed vs open areas. Patients diagnosed with hypertension were recruited during office visits. Read More

    Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies.
    Can J Cardiol 2017 Dec 29;33(12):1624-1632. Epub 2017 Jul 29.
    Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China. Electronic address:
    Background: Although basic research has suggested that oxidized low-density lipoprotein (ox-LDL) is involved in the pathogenesis of atherosclerosis, population observational studies have yielded conflicting results about the association between circulating ox-LDL and atherosclerotic cardiovascular disease (ASCVD). Therefore, we performed a systematic review and meta-analysis of currently available observational studies to verify the association between circulating ox-LDL and ASCVD.

    Methods: We systematically searched PubMed and the Cochrane Library from their inception to March 27, 2017, for nested case-control studies, case-cohort studies, and prospective cohort studies on the relationship between ox-LDL and ASCVD. Read More

    Autologous Bone Marrow Stem Cell Therapy in Patients With ST-Elevation Myocardial Infarction: A Systematic Review and Meta-analysis.
    Can J Cardiol 2017 Dec 7;33(12):1611-1623. Epub 2017 Oct 7.
    The George and Fay Yee Center for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
    Background: Randomized controlled trials (RCTs) on bone marrow stem cell (BMSC) therapy in ST-elevation myocardial infarction (STEMI) patients have reported conflicting results. Our main objective was to critically appraise and meta-analyze best-available evidence on efficacy and safety of intracoronary administration of autologous BMSC therapy in STEMI patients after primary percutaneous coronary intervention.

    Methods: We conducted a search of MEDLINE, PubMed, EMBASE, CENTRAL, Global Health, CINAHL, and conference proceedings in February 2017. Read More

    A Practical Approach to Avoiding Cardiovascular Adverse Effects of Psychoactive Medications.
    Can J Cardiol 2017 Dec 11;33(12):1577-1586. Epub 2017 Sep 11.
    Research Centre, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:
    Drugs that act on mental state, generally termed "psychoactive agents," are among the most widely used medications in medicine. Psychoactive agents can affect the cardiovascular system and must be used carefully to avoid negative cardiovascular consequences. In the present article we review the potential adverse cardiovascular consequences of psychoactive medications and provide suggestions for practical approaches to avoiding them. Read More

    Bipolar Disorder and the Vascular System: Mechanisms and New Prevention Opportunities.
    Can J Cardiol 2017 Dec 13;33(12):1565-1576. Epub 2017 Oct 13.
    Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Departments of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Bipolar disorder (BD) is associated with excessive prevalence and premature onset of cardiovascular disease (CVD). This association is observed internationally in clinical as well as predominantly untreated epidemiologic samples. A number of factors might explain this association in part, including excessive rates of traditional cardiovascular risk factors (CVRFs), suboptimal lifestyle behaviour s relating to physical activity, nutrition, and use of alcohol, tobacco, and drugs, and the use of psychiatric medications with propensity for causing CVRFs. Read More

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