6,127 results match your criteria Canadian Journal of Cardiology[Journal]


Enormous Aneurysm in Coronary Artery Fistula With Immunoglobulin G4-Related Disease.

Can J Cardiol 2019 Feb 5;35(2):230.e1-230.e3. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.

We report the first case of coronary artery fistula with aneurysmal change in a patient with immunoglobulin G4-related disease (IgG4-RD). This case revealed concomitant coronary artery dilation, pericardial inflammatory nodules, and coronary-pulmonary fistula aneurysm in addition to several IgG4-RD lesions. Each of these features was located in close proximity to the thickened pericardium. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.030DOI Listing
February 2019
1 Read

Stress-Induced Cardiomyopathy Complicated by Dynamic Left Ventricular Outflow Obstruction, Cardiogenic Shock, and Ventricular Septal Rupture.

Can J Cardiol 2019 Feb 7;35(2):229.e7-229.e9. Epub 2018 Dec 7.

Department of Cardiovascular Sciences, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA. Electronic address:

We describe the case of a 68-year-old woman presenting with stress cardiomyopathy (SCM), with concomitant cardiogenic shock, left ventricular outflow tract obstruction, and ventricular septal rupture. These complications have not simultaneously been reported in a single SCM case. The importance of early diagnosis of serial complications of SCM and using mechanical circulatory support as a treatment strategy are highlighted. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.005DOI Listing
February 2019
2 Reads

Contrary to Expectations: Off-Label Transcatheter Aortic Valve Replacement in the Case of Left Ventricular Outflow Tract Obstruction.

Can J Cardiol 2019 Feb 12;35(2):229.e5-229.e6. Epub 2018 Dec 12.

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

We present the case of a 71-year-old woman who showed recurrent signs of congestive heart failure with the need of rehospitalization after double valve (mitral and aortic) replacement. Extensive diagnostic workup revealed a moderate aortic stenosis and additionally a significant left ventricular outflow tract obstruction. The tissue overgrowth might be attributed to an inflammatory reaction with extensive pannus deposit after aortic valve surgery. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.007DOI Listing
February 2019
2 Reads

Traumatic Pulmonary Hypertension Secondary to Arteriovenous Fistula and Remote Gunshot Wound.

Can J Cardiol 2019 Feb 8;35(2):229.e11-229.e13. Epub 2018 Dec 8.

Division of Respiratory and Sleep Medicine, Departments of Medicine and Critical Care Medicine, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.

Pulmonary hypertension is a known complication of high-flow arteriovenous fistulas (AVFs). We present a case of a 58-year-old man who sustained a gunshot wound 6.5 years before presentation for worsening pulmonary hypertension (PH). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.003DOI Listing
February 2019
1 Read

Marijuana Lollipop-Induced Myocardial Infarction.

Can J Cardiol 2019 Feb;35(2):229.e1-229.e3

Horizon Health Department of Cardiology, Saint John, New Brunswick, Canada. Electronic address:

A 70-year-old man with known coronary artery disease presented with crushing chest pain, diaphoresis, and pallor after consuming a marijuana lollipop; the pain began within 30 minutes of consumption. His troponin T increased from 94 ng/L to 216 ng/L, with slight ST changes but no gross ST elevations. Discharge diagnosis was non-ST-elevation myocardial infarction, and subsequent nuclear medicine wall motion studies showed worsening ejection fraction (40% to 31%). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.033DOI Listing
February 2019

Minimally Invasive Surgical Aortic Valve Replacement: An Overview of Recent Advances.

Can J Cardiol 2019 Feb 4;35(2):225-228. Epub 2018 Dec 4.

Section of Cardiac Surgery, Division of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Aortic valve replacement (AVR) is the only definitive treatment for severe aortic stenosis. Options for valve replacement include surgical AVR (SAVR) and percutaneous transcatheter AVR. Although transcatheter AVR has recently been shown to be the optimal approach for high-risk patients, SAVR is the gold standard for patients with low and intermediate surgical risk. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.027DOI Listing
February 2019
2 Reads

What the Cardiologist Should Know About Mitochondrial Cardiomyopathy?

Can J Cardiol 2019 Feb 29;35(2):221-224. Epub 2018 Nov 29.

Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Quebec, Canada. Electronic address:

Mitochondrial diseases are a heterogeneous group of rare hereditary disorders that may manifest with single organ involvement or as multisystemic disease. The pathophysiology of mitochondrial disease is complex and related to mutations of genes encoding mitochondrial proteins that are crucial to the cellular respiratory chain. Given its almost exclusive aerobic metabolism, the heart is particularly susceptible to mitochondrial dysfunction and commonly involved in mitochondrial disorders. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.018DOI Listing
February 2019
2 Reads

Fontan-Associated Liver Disease: Evidence for Early Surveillance of Liver Health in Pediatric Fontan Patients.

Can J Cardiol 2019 Feb 29;35(2):217-220. Epub 2018 Nov 29.

Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

The growing awareness of Fontan-associated liver disease (FALD) in adults with Fontan physiology has provided the impetus to better understand the natural history of FALD and develop a reliable noninvasive method to diagnose and monitor liver health in this population. Biochemical and imaging tests have been investigated to determine their association with liver pathology. The congestive hepatopathy that develops after the Fontan procedure has made interpreting these tests challenging. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.019DOI Listing
February 2019
1 Read

MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by High-Fat Diets.

Can J Cardiol 2019 Feb 29;35(2):208-216. Epub 2018 Nov 29.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, and Hubei Key Laboratory of Cardiology, Hubei, China. Electronic address:

Background: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.020DOI Listing
February 2019
1 Read

Impact of Discharge Location After Transcatheter Aortic Valve Replacement on 1-Year Outcomes in Women: Results From the WIN-TAVI Registry.

Can J Cardiol 2019 Feb 12;35(2):199-207. Epub 2018 Dec 12.

Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Several clinical and procedural factors determine outcomes after transcatheter aortic valve replacement (TAVR), but data are scarce on the impact of post-TAVR discharge disposition on long-term outcomes. We sought to analyse whether discharge location after TAVR is associated with 1-year outcomes in women undergoing contemporary TAVR.

Methods: The Women's INternational Transcatheter Aortic Valve Implantation (WIN-TAVI) registry is the first all-female TAVR registry to study the safety and performance of contemporary TAVR in women (n = 1019). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.035DOI Listing
February 2019
1 Read

Shortening Hospital Stay Is Feasible and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension Treated With Balloon Pulmonary Angioplasty.

Can J Cardiol 2019 Feb 7;35(2):193-198. Epub 2018 Dec 7.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications.

Methods: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.001DOI Listing
February 2019

Clinical Utility of Pre-Exercise Stress Testing in People With Diabetes.

Can J Cardiol 2019 Feb 20;35(2):185-192. Epub 2018 Nov 20.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.

Background: Although suggested by practice guidelines, the need for pre-exercise stress testing in asymptomatic people with diabetes remains controversial. We examined the utility of screening with pre-exercise stress testing in patients with diabetes.

Methods: We completed a cohort study, evaluating patients with diabetes who attended an exercise program intake session between 2007 and 2012. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.007DOI Listing
February 2019
1 Read

Variability in the Echocardiographic Evaluation of the Systemic Right Ventricle.

Can J Cardiol 2019 Feb 30;35(2):178-184. Epub 2018 Nov 30.

Adult Congenital Heart Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Background: Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function.

Methods: Six independent observers retrospectively interpreted 44 previously acquired echocardiograms (25 patients with TGA/AS and 19 patients with ccTGA). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.021DOI Listing
February 2019
1 Read

Health Care Utilization After Ventricular Tachycardia Ablation: A Propensity Score-Matched Cohort Study.

Can J Cardiol 2019 Feb 25;35(2):169-177. Epub 2018 Oct 25.

University Health Network, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Catheter ablation of ventricular tachycardia (VT) can reduce the burden of ventricular arrhythmia (VA) but its effect on health care utilization and costs after such therapy is poorly known. We sought to compare the rates of cardiovascular (CV)-related hospitalizations, survival, and health care costs in patients with recurrent VT treated either with VT ablation or with medical therapy.

Methods: One-hundred implantable cardioverter-defibrillator patients with structural heart disease who underwent VT ablation were included. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.011DOI Listing
February 2019
1 Read

Association Between Patient and Physician Sex and Physician-Estimated Stroke and Bleeding Risks in Atrial Fibrillation.

Can J Cardiol 2019 Feb 3;35(2):160-168. Epub 2018 Dec 3.

Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada. Electronic address:

Background: Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.023DOI Listing
February 2019
1 Read

Cardioprotective Effect of Statins in Patients With HER2-Positive Breast Cancer Receiving Trastuzumab Therapy.

Can J Cardiol 2019 Feb 4;35(2):153-159. Epub 2018 Dec 4.

Division of Cardiology, Peter Munk Cardiac Center, Ted Rogers Program in Cardiotoxicity Prevention, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Statins can reduce the risk of anthracycline-induced cardiotoxicity. Whether such cardioprotective effects can be seen in trastuzumab-treated patients has not been explored.

Methods: Consecutive women with HER2+ breast cancer who received trastuzumab with or without anthracyclines were identified retrospectively. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.028DOI Listing
February 2019
1 Read

Pre-exercise Stress Testing in Type 2 Diabetes: Another Case of Choosing Wisely?

Can J Cardiol 2019 Feb 11;35(2):150-152. Epub 2018 Dec 11.

Department of Medicine, Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.008DOI Listing
February 2019

Health Economic Analysis of Catheter Ablation for Ventricular Tachycardia: Breaking Even With Medical Therapy?

Can J Cardiol 2019 Feb 12;35(2):147-149. Epub 2018 Dec 12.

Arrhythmia Service, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.12.012DOI Listing
February 2019
1 Read

Physician Estimation of Thrombotic and Bleeding Risks in Atrial Fibrillation: Let's Talk About Sex.

Can J Cardiol 2019 Feb 12;35(2):145-146. Epub 2018 Dec 12.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.011DOI Listing
February 2019
1 Read

Managing Cannabis Use in Patients With Cardiovascular Disease.

Authors:
Neal L Benowitz

Can J Cardiol 2019 Feb 29;35(2):138-141. Epub 2018 Dec 29.

Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, Departments of Medicine, and Biopharmaceutical Sciences; Center for Tobacco Control Research and Education, University of California, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.033DOI Listing
February 2019

The Canadian Journal of Cardiology: Open and Growing.

Authors:
Stanley Nattel

Can J Cardiol 2019 Feb 3;35(2):133-137. Epub 2019 Jan 3.

From the Department of Medicine, Montréal Heart Institute and Université de Montréal, and Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; IHU Liryc and Fondation Bordeaux Université, Bordeaux, France; and Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.037DOI Listing
February 2019

2019 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Guidelines on the Acute Management of ST-Elevation Myocardial Infarction: Focused Update on Regionalization and Reperfusion.

Can J Cardiol 2019 Feb;35(2):107-132

Southlake Regional Health Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Rapid reperfusion of the infarct-related artery is the cornerstone of therapy for the management of acute ST-elevation myocardial infarction (STEMI). Canada's geography presents unique challenges for timely delivery of reperfusion therapy for STEMI patients. The Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology STEMI guideline was developed to provide advice regarding the optimal acute management of STEMI patients irrespective of where they are initially identified: in the field, at a non-percutaneous coronary intervention-capable centre or at a percutaneous coronary intervention-capable centre. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.031DOI Listing
February 2019
1 Read
3.711 Impact Factor

Cardiac Surgery in HIV Patients: State of the Art.

Can J Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada.

The clinical status of HIV infection has changed dramatically with the introduction of combined antiretroviral therapy. Patients with HIV are now living long enough to be susceptible to chronic illnesses, such as coronary disease and nonischemic cardiomyopathy, which can be consequences of the combined antiretroviral therapy treatment itself. Cardiovascular diseases are a major source of morbidity and mortality in HIV-positive patients. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.006DOI Listing
November 2018
2 Reads

Lipid Abnormalities in Persons Living With HIV Infection.

Can J Cardiol 2018 Nov 15. Epub 2018 Nov 15.

Division of Cardiology, Zuckerberg San Francisco General Hospital, and Department of Medicine, University of California, San Francisco, California, USA.

Lipid abnormalities are prevalent among persons living with HIV infection and contribute to increasing the risk of cardiovascular events. Antiretroviral therapy (ART) is associated with lipid abnormalities, most commonly hypertriglyceridemia, but also increases in low-density lipoprotein cholesterol and total cholesterol. Different classes of ART, and different drugs within classes, have differing effects on lipid levels, but in general newer drugs have more favourable effects compared with older ones. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183127
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http://dx.doi.org/10.1016/j.cjca.2018.11.005DOI Listing
November 2018
7 Reads

Statins in Cardio-oncology: Holy Grail or Epiphenomenon.

Can J Cardiol 2019 Feb 26;35(2):142-144. Epub 2018 Dec 26.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.026DOI Listing
February 2019
2 Reads

Cardiomyopathy and Heart Failure in Patients With HIV Infection.

Can J Cardiol 2018 Oct 19. Epub 2018 Oct 19.

Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, New York, USA. Electronic address:

With the advent and widespread use of antiretroviral therapy (ART), the epidemiology of cardiomyopathy and heart failure (HF) associated with HIV infection is changing. Near-normal life expectancy in contemporary HIV-infected populations has been associated with prolonged exposure to increased cardiometabolic burden and chronic immune activation and systemic inflammation. Therefore, the pre-ART phenotype of HIV-associated cardiomyopathy with overt left ventricular systolic dysfunction and poor prognosis has been replaced over time by cardiomyopathy with a more insidious course, more frequent ischemic background, and highly prevalent left ventricular diastolic dysfunction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183122
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http://dx.doi.org/10.1016/j.cjca.2018.10.009DOI Listing
October 2018
6 Reads

The Heart as a Transplanted Organ: Unspoken Struggles of Personal Identity Among Adolescent Recipients.

Can J Cardiol 2019 Jan 18;35(1):96-99. Epub 2018 Oct 18.

Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Departments of Pediatrics, Surgery and Medical Microbiology/Immunology, Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada.

In adult heart transplant recipients, a transformation of the self has been observed simultaneous to the "emotional integration" of the heart following transplantation. However, the experiences of adolescents following heart transplantation are virtually unexplored within the current literature. Our qualitative findings address this gap and explore struggles with personal identity in adolescent heart transplant recipients. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.006DOI Listing
January 2019
1 Read

Automated External Defibrillator and Emergency Action Plan Preparedness Amongst Canadian University Athletics.

Can J Cardiol 2019 Jan 26;35(1):92-95. Epub 2018 Oct 26.

Department of Medicine, SportsCardiology BC, University of British Columbia, Vancouver, British Columbia, Canada; Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Sudden cardiac death is the leading medical cause of death in athletes. The use of an automated external defibrillator (AED) and an emergency action plan (EAP) are effective strategies for improving outcomes of sudden cardiac arrest. The availability of an AED and the presence of an EAP amongst Canadian universities (U-SPORTS) are unknown. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.012DOI Listing
January 2019
2 Reads

Change in Proteinuria or Albuminuria as a Surrogate for Cardiovascular and Other Major Clinical Outcomes: A Systematic Review and Meta-analysis.

Can J Cardiol 2019 Jan 29;35(1):77-91. Epub 2018 Oct 29.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; The George Institute for Global Health, University of New South Wales, Sydney, Australia. Electronic address:

Background: There is ongoing controversy around the surrogacy of proteinuria or albuminuria, particularly for cardiovascular (CV) outcomes, which remain the leading cause of morbidity and mortality among patients with chronic kidney disease. We performed a systematic review and meta-analysis of the literature to assess the surrogacy of changing proteinuria or albuminuria for CV events, end-stage renal disease (ESRD), and all-cause mortality.

Methods: CENTRAL, EMBASE, and MEDLINE were searched (from inception to October 2017). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.014DOI Listing
January 2019
1 Read

Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia.

Can J Cardiol 2019 Jan 14;35(1):68-76. Epub 2018 Nov 14.

Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China. Electronic address:

Background: Preeclampsia increases the risk of heart disease. Defects in the protease corin, including the variant T555I/Q568P found in approximately 12% of blacks, have been associated with preeclampsia and cardiac hypertrophy. The objective of this study was to investigate the role of corin and the T555I/Q568P variant in preeclampsia-associated cardiac alterations using genetically modified mouse models. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314216PMC
January 2019
2 Reads
3.711 Impact Factor

Variables Associated With Cardiac Surgical Waitlist Mortality From a Population-Based Cohort.

Can J Cardiol 2019 Jan 19;35(1):61-67. Epub 2018 Oct 19.

Division of Cardiology, University of Alberta Hospital, Edmonton, Alberta, Canada; Department of Critical Care, University of Alberta Hospital, Edmonton, Alberta, Canada. Electronic address:

Background: Cardiac surgery waitlist recommendations, which were developed based on expert opinion, poorly predict preoperative mortality. Studies reporting risk factors for waitlist mortality have not evaluated the risks including nonadherence to waitlist benchmarks.

Methods: In patients who underwent cardiac surgery or died on the waitlist between 2005 and 2015, we used a Fine and Gray competing risk model to identify independent predictors of waitlist mortality in 12,106 patients scheduled for urgent, semiurgent, or nonurgent surgery. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.007DOI Listing
January 2019
1 Read

Myocardial Partition Coefficient of Gadolinium: A Pilot Study in Patients With Acute Myocarditis, Chronic Myocardial Infarction, and in Healthy Volunteers.

Can J Cardiol 2019 Jan 16;35(1):51-60. Epub 2018 Oct 16.

Philippa & Marvin Carsley CMR Center, Montréal Heart Institute, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: The tissue-blood partition coefficient (PC) of gadolinium, derived from T1 measurements, reflects myocardial connective tissue fraction and tissue injury, increasing in proportion with edema or fibrosis. We determined the myocardial PC of gadolinium in patients with acute myocarditis, chronic myocardial infarction (MI), and healthy volunteers. We hypothesized that the characteristics of the injured myocardium in patients with MI and myocarditis may differ and that the PC will be higher in chronically injured myocardium (MI) compared with acutely injured myocardium (myocarditis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183122
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http://dx.doi.org/10.1016/j.cjca.2018.10.005DOI Listing
January 2019
3 Reads

Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection.

Can J Cardiol 2019 Jan 22;35(1):42-50. Epub 2018 Nov 22.

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Electronic address:

Background: Previous studies have shown that thrombospondin 1 (TSP-1) is involved in cardiovascular diseases, such as atherosclerosis and abdominal aortic aneurysm. However, TSP-1 expression levels in human aortic dissection (AD) remain unknown.

Methods: TSP-1 levels were detected in aortas collected from control subjects and AD patients. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.008DOI Listing
January 2019
3 Reads

Feasibility and Reliability of Nonexpert POCUS for Cardiovascular Preparticipation Screening of Varsity Athletes: The SHARP Protocol.

Can J Cardiol 2019 Jan 14;35(1):35-41. Epub 2018 Nov 14.

Department of Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address:

Background: Point of care ultrasound (POCUS) is a potential adjunctive cardiovascular preparticipation screening modality for young competitive athletes. A novel cardiac POCUS screening protocol, Screening the Heart of the Athlete Research Program (SHARP), was developed for nonexpert examiners to assess common structural etiologies associated with sudden cardiac arrest/death (SCA/D).

Methods: Assessment of primary outcomes of feasibility, and reliability of obtained measurements, performed by comparison to formal transthoracic echocardiogram was undertaken. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.003DOI Listing
January 2019
3 Reads

Clinical Significance of Electromechanical Dyssynchrony and QRS Narrowing in Patients With Heart Failure Receiving Cardiac Resynchronization Therapy.

Can J Cardiol 2019 Jan 14;35(1):27-34. Epub 2018 Nov 14.

GCS-Groupement des hôpitaux de l'institut Catholique de Lille, Cardiology Department, Université Catholique de Lille, Lille, France; Laboratoire UPJCV, Université de Picardie, Amiens, France. Electronic address:

Background: We hypothesized that preoperative electromechanical dyssynchrony amenable to cardiac resynchronization therapy (CRT) and QRS narrowing immediately after CRT are both correlated and have a cumulative impact on response and outcome after CRT.

Methods: A total of 233 CRT candidates (heart failure New York Heart Association classes II-IV, ejection fraction < 35%, QRS ≥ 120 milliseconds, 44% women, 71 ± 11 years old) were prospectively included. Preoperative electromechanical dyssynchrony amenable to CRT was assessed by septal deformation patterns using speckle tracking echocardiography. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.019DOI Listing
January 2019
3 Reads

Carotid Artery Function Is Restored in Subjects With Elevated Cardiovascular Disease Risk After a 12-Week Physical Activity Intervention.

Can J Cardiol 2019 Jan 14;35(1):23-26. Epub 2018 Nov 14.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Sympathetic nervous system activation elicits carotid artery vasodilation in healthy subjects, yet vasoconstriction in those with cardiovascular disease (CVD). Whether carotid artery vasoconstriction can be reversed is currently unknown. Nineteen subjects with increased risk for CVD were referred to a 12-week physical activity intervention, and 12 participants with increased risk for CVD were recruited as a no treatment control group. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.015DOI Listing
January 2019
1 Read

At the Core of Preeclampsia Genetics: Key Insights into the Neurohormonal Contribution to Hypertensive Diseases of Pregnancy and Their Complications.

Authors:
Daniel Vaiman

Can J Cardiol 2019 Jan 3;35(1):19-22. Epub 2018 Dec 3.

Department of Development, Reproduction, Cancer, Institut Cochin, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183131
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http://dx.doi.org/10.1016/j.cjca.2018.11.026DOI Listing
January 2019
2 Reads

Smashing Low-Density Lipoprotein Levels and Preventing Coronary Allograft Vasculopathy: One Heart Transplant Patient at a Time.

Can J Cardiol 2019 Jan 30;35(1):17-18. Epub 2018 Nov 30.

From Queens University and Research Institute of the McGill University Health Center, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.11.022DOI Listing
January 2019
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Point-of-Care Ultrasound (POCUS) and the Screening of Canadian Collegiate Athletes.

Authors:
Andrew Pipe

Can J Cardiol 2019 Jan 3;35(1):15-16. Epub 2018 Dec 3.

Division of Prevention & Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.11.025DOI Listing
January 2019
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Speckle Tracking for Cardiac Resynchronization Therapy Implantation: Have We Found the Perfect Match?

Can J Cardiol 2019 Jan 3;35(1):12-14. Epub 2018 Dec 3.

Southlake Regional Health Centre, Newmarket, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.11.024DOI Listing
January 2019
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Infective Endocarditis Due to Treponema pallidum: A Case Diagnosed Using Polymerase Chain Reaction Analysis of Aortic Valve.

Can J Cardiol 2019 Jan 22;35(1):104.e9-104.e11. Epub 2018 Nov 22.

Department of Cardiology, Japanese Red Cross Musashino Hospital, Tokyo, Japan.

Syphilis is a sexually transmitted disease caused by Treponema pallidum. Syphilitic aortitis might coexist in a dysfunctional aortic valve, but the etiology remains unclear, because microbiological diagnosis is difficult. A 62-year-old man with low-grade fever was diagnosed with aortitis and infective endocarditis, due to Treponema pallidum infection, using polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.009DOI Listing
January 2019
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Acute Decompensated Heart Failure After Initiation of Amiodarone in a Patient With Anderson-Fabry Disease.

Can J Cardiol 2019 Jan 16;35(1):104.e5-104.e7. Epub 2018 Oct 16.

Departments of Medical Genetics and Pediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

A 54-year-old man with the lysosomal storage disorder Anderson-Fabry disease (AFD) and cardiac involvement was placed on amiodarone for treatment of symptomatic paroxysmal atrial fibrillation. Shortly thereafter, he developed symptoms of acute decompensated heart failure, requiring hospital admission. Endomyocardial biopsy demonstrated findings consistent with AFD and possible amiodarone toxicity. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.004DOI Listing
January 2019
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Safety and Efficacy of PCSK9 Inhibitors After Heart Transplantation.

Can J Cardiol 2019 Jan 14;35(1):104.e1-104.e3. Epub 2018 Nov 14.

Stanford University, Division of Cardiovascular Medicine, Heart Transplantation, Palo Alto, California, USA. Electronic address:

Dyslipidemia is common in patients undergoing heart transplantation and is associated with the progression of cardiac allograft vasculopathy. Two monoclonal antibodies directed against PCSK9i-evolocumab and alirocumab-are currently available. However, their use, safety and efficacy in the post-transplant setting have not been studied. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.004DOI Listing
January 2019
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Use of Administrative Data to Monitor Cardiac Implantable Electronic Device Complications.

Can J Cardiol 2019 Jan 13;35(1):100-103. Epub 2018 Nov 13.

Division of Cardiology, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.

Cardiac implantable electronic devices (CIEDs) are increasingly used in the Canadian population, because of expanding indications and an aging population. Device-related complications are a source of morbidity and mortality. There is currently no comprehensive monitoring strategy of CIED-related complications in Canada. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.018DOI Listing
January 2019
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Canadian Cardiovascular Society/Canadian Heart Rhythm Society Joint Position Statement on the Cardiovascular Screening of Competitive Athletes.

Can J Cardiol 2019 Jan 22;35(1):1-11. Epub 2018 Nov 22.

University of London, London, Great Britain.

Sudden cardiac death (SCD), especially in a young seemingly healthy individual, is a tragic and highly publicized event, which is often followed by a strong emotional reaction from the public and medical community." Although rare, SCD in the young is devastating to families and communities, underpinning our society's desire to avoid any circumstances predisposing to the loss of human life during exertion. The Canadian Cardiovascular Society Position Statement on the cardiovascular screening of athletes provides evidence-based recommendations for Canadian sporting organizations and institutions with a focus on the role of routine electrocardiogram (ECG) screening in preventing SCD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183124
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http://dx.doi.org/10.1016/j.cjca.2018.10.016DOI Listing
January 2019
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Successful Use of Ranolazine in a Patient With Vasospastic Angina.

Can J Cardiol 2019 Jan 26;35(1):104.e13-104.e14. Epub 2018 Oct 26.

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http://dx.doi.org/10.1016/j.cjca.2018.10.013DOI Listing
January 2019
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Efficacy of Simultaneous Kissing Stent Technique Using Two Polytetrafluoroethylene-Covered Stents for Severe Coronary Perforation Involving Bifurcation.

Can J Cardiol 2018 Dec 17;34(12):1689.e1-1689.e2. Epub 2018 Aug 17.

Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.08.021DOI Listing
December 2018
2 Reads