126,836 results match your criteria Canadian Journal On Aging-revue Canadienne Du Vieillissement[Journal]


Large-scale implementation of a pragmatic atrial fibrillation screening program in canadian community practice.

Pacing Clin Electrophysiol 2020 May 27. Epub 2020 May 27.

Université Laval, Quebec City, Canada.

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http://dx.doi.org/10.1111/pace.13966DOI Listing

A risk assessment tool for predicting fragility fractures and mortality in the elderly.

J Bone Miner Res 2020 May 27. Epub 2020 May 27.

Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, Australia.

Existing fracture risk assessment tools are not designed to predict fracture-associated consequences, possibly contributing to the current under-management of fragility fractures worldwide. We aimed to develop a risk assessment tool for predicting the conceptual risk of fragility fractures and consequences. The study involved 8965 people aged ≥60 years from the Dubbo Osteoporosis Epidemiology Study and the Canadian Multicentre Osteoporosis Study. Read More

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http://dx.doi.org/10.1002/jbmr.4100DOI Listing

A comparison of consumer-grade electronic radon monitors.

J Radiol Prot 2020 May 27. Epub 2020 May 27.

Radiation Safety Institute of Canada, Saskatoon, Saskatchewan, CANADA.

Radon is a radioactive gas which is naturally occurring in soil and can accumulate to concentrated levels inside homes and buildings. Exposure to elevated levels of radon leads to an increased risk of developing lung cancer. In recent years there has been a rise in the popularity of consumer-grade electronic radon monitors. Read More

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http://dx.doi.org/10.1088/1361-6498/ab96d6DOI Listing

Fourier transform infrared spectroscopy as a surrogate tool for the quantification of naphthenic acids in oil sands process water and groundwater.

Sci Total Environ 2020 May 7;734:139191. Epub 2020 May 7.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada. Electronic address:

Naphthenic acid fraction compounds (NAFCs), defined herein as the polar organic compounds extracted from the acidified oil sands process water (OSPW) samples using dichloromethane, are becoming the research hotspot due to their presence in large amount in OSPW and along with other potentially NA-contaminated water streams from the mining site. Fourier transform infrared spectroscopy (FTIR) method is commonly used to quantify NAFCs and assumes that the total NA concentration is measured as the sum of the responses for all carboxylic acid functional groups. In this study, the NAFCs in various OSPW and groundwater (GW) samples from an active oil sands mining site were analyzed using FTIR. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139191DOI Listing

Translating 'protein foods' from the new Canada's Food Guide to consumers: Knowledge gaps and recommendations.

Appl Physiol Nutr Metab 2020 May 27. Epub 2020 May 27.

University of Manitoba , Room 209 Human Ecology , Department of Human Nutritional Sciences , Winnipeg, Manitoba, Canada , R3T 2N2 ;

The revised version of Canada's Food Guide, released in January 2019, issued new guidance by combining meat and alternatives with milk and alternatives into a single group called 'protein foods' and emphasized selecting plant-based foods from this category more often. Though the changes represent a simple depiction of a healthy plate, the new Food Guide has opened knowledge gaps about 'protein foods' and exposed new concerns about the interpretation and implementation of the Food Guide among vulnerable groups, particularly children and the elderly. To address key knowledge and research gaps, nutrition leaders need to reach a consensus on key messages to best inform the development of tools and resources to support practitioners in translating messages to consumers, including foodservice standards. Read More

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http://dx.doi.org/10.1139/apnm-2020-0192DOI Listing

Composite lipid emulsion for the infant at risk of intestinal failure associated liver disease: the Canadian perspective.

J Pediatr Gastroenterol Nutr 2020 May 26. Epub 2020 May 26.

Division of General and Thoracic Surgery, University of Toronto, Ontario, Canada.

Currently, in North America we are fortunate to have a number of available options for lipid emulsions to be used in the parenteral nutrition regimens for infants and children, including for long term parenteral nutrition given intestinal failure. Neonates and infants in particular are at risk for intestinal failure associated liver disease (IFALD). The choice of parenteral lipid emulsion will influence the risk and severity of IFALD. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002794DOI Listing

Branching points of primary afferent fibres are vital for the modulation of fibre excitability by epidural DC polarization and by GABA in the rat spinal cord.

J Neurophysiol 2020 May 27. Epub 2020 May 27.

Neuroscience and Physiology, University of Gothenburg, Sweden.

The aim of the study was to examine whether the sustained increases in the excitability of afferent fibres traversing the dorsal columns evoked by their polarization depend on the branching points of these fibres. To this end, effects of epidural polarization were compared in four spinal regions in deeply anaesthetized rats; two with the densest collateralization of muscle afferent fibres (above motor nuclei and Clarke's column) and two where the collateralization is more sparse (rostral and caudal to motor nuclei respectively. The degree of collateralization in different segments was reconstructed in retrogradely labelled afferent fibres in the rat. Read More

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http://dx.doi.org/10.1152/jn.00161.2020DOI Listing

Impact of the New McGill Undergraduate Medical Curriculum on Medical Students' Diagnostic Accuracy of Common Dermatoses Encountered in Primary Care.

J Cutan Med Surg 2020 May 27:1203475420928906. Epub 2020 May 27.

Division of Dermatology, McGill University - Jewish General Hosptial, Montreal, QC, Canada.

Background: The McGill Faculty of Medicine implemented a new undergraduate medical curriculum in 2013 with additional preclinical lectures in dermatology. At the time of writing, no Canadian prospective study has been published on undergraduate dermatology training in the context of a complete curricular renewal.

Objectives: Our study was designed to determine the impact of increasing preclinical teaching in dermatology on medical students' diagnostic accuracy and learning retention of common dermatoses encountered in primary care. Read More

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http://dx.doi.org/10.1177/1203475420928906DOI Listing

Glucose-induced duration-dependent genome-wide DNA methylation changes in human endothelial cells.

Am J Physiol Cell Physiol 2020 May 27. Epub 2020 May 27.

Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.

DNA methylation, a critical epigenetic mechanism, plays an important role in governing gene expressions during biological processes such as aging, which is well known to be accelerated in hyperglycemia (diabetes). In the present study, we investigated the effects of glucose on whole-genome DNA methylation in small (HRECs) and large (HUVECs) vessel endothelial cell (EC) lines exposed to basal or high glucose-containing media for variable lengths of time. Using the Infinium EPIC array, we obtained 773,133 CpG sites (probes) for analysis. Read More

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http://dx.doi.org/10.1152/ajpcell.00011.2020DOI Listing

Validation of the 7-item Functional Assessment of Cancer Therapy-General (FACT-G7) as a short measure of quality of life in patients with advanced cancer.

Cancer 2020 May 27. Epub 2020 May 27.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Background: Assessing quality of life is essential for individuals with advanced cancer, but lengthy assessments can be burdensome. The authors investigated the psychometric characteristics of the FACT-G7, a 7-item quality-of-life measure derived from the Functional Assessment of Cancer Therapy-General (FACT-G) scale, in advanced cancer.

Methods: Data were obtained from outpatients with advanced cancer who were enrolled in a randomized controlled trial of early palliative care. Read More

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http://dx.doi.org/10.1002/cncr.32981DOI Listing

Does the public feel prepared to be substitute decision-makers? Gaps in preparedness and support for a high school curriculum: a national survey.

Age Ageing 2020 May 27. Epub 2020 May 27.

Department of Emergency Medicine, University of Ottawa, Ottawa, Canada.

Background: Substitute decision-makers (SDMs) make decisions on behalf of patients who do not have capacity, in line with previously expressed wishes, values and beliefs. However, miscommunications and poor awareness of previous wishes often lead to inappropriate care. Increasing public preparedness to communicate on behalf of loved ones may improve care in patients requiring an SDM. Read More

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http://dx.doi.org/10.1093/ageing/afaa100DOI Listing

Routine gastric residual volume measurement to guide enteral feeding in mechanically ventilated infants and children: the GASTRIC feasibility study.

Health Technol Assess 2020 May;24(23):1-120

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Background: The routine measurement of gastric residual volume to guide the initiation and delivery of enteral feeding is widespread in paediatric intensive care and neonatal units, but has little underlying evidence to support it.

Objective: To answer the question: is a trial of no gastric residual volume measurement feasible in UK paediatric intensive care units and neonatal units?

Design: A mixed-methods study involving five linked work packages in two parallel arms: neonatal units and paediatric intensive care units. Work package 1: a survey of units to establish current UK practice. Read More

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http://dx.doi.org/10.3310/hta24230DOI Listing

Health Service Use among Individuals with Depression and Psychological Distress: A Population-Based Cohort Study in Ontario, Canada.

Can J Psychiatry 2020 May 27:706743720927826. Epub 2020 May 27.

ICES, Toronto, Canada.

Objectives: Relatively little is known about how health-care utilization differs among individuals with psychological distress compared to those with major depressive disorder (MDD).

Methods: Ontario participants of the Canadian Community Health Survey Cycle 1.2 (2002) were linked to health administrative data to follow their health-care utilization patterns for up to 15 years. Read More

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http://dx.doi.org/10.1177/0706743720927826DOI Listing

Economic Burden and Healthcare Resource Use for Thoracic Aortic Dissections and Thoracic Aortic Aneurysms-A Population-Based Cost-of-Illness Analysis.

J Am Heart Assoc 2020 May 27:e014981. Epub 2020 May 27.

Institute for Clinical and Evaluative Sciences Queen's University Kingston Ontario, Canada.

Background Thoracic aortic dissections (TADs) and thoracic aortic aneurysms (TAAs) are resource intensive. We sought to determine economic burden and healthcare resource use to guide health policy. Methods and Results Using universal healthcare coverage data for Ontario, Canada, from 2003 to 2016, a cost-of-illness analysis was performed. Read More

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http://dx.doi.org/10.1161/JAHA.119.014981DOI Listing

Communicating risks to drinkers: testing alcohol labels with a cancer warning and national drinking guidelines in Canada.

Can J Public Health 2020 May 26. Epub 2020 May 26.

Canadian Institute for Substance Use Research, University of Victoria, Victoria, British Columbia, Canada.

Objective: To test whether alcohol labels with a cancer warning and national drinking guidelines are an effective tool for supporting more informed and safer alcohol consumption among drinkers.

Methods: Using a quasi-experimental design, pre-post surveys were conducted with 1647 cohort participants systematically selected in liquor stores in two matched sites in Canada in 2017-2018. Enhanced labels designed according to best practices for effective product labels were applied to alcohol containers in the liquor store in the intervention site for one month, and usual practice continued in the comparison site. Read More

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http://dx.doi.org/10.17269/s41997-020-00320-7DOI Listing

Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-HR synergistically kill multi-drug resistant breast cancer cells.

Sci Rep 2020 May 26;10(1):8726. Epub 2020 May 26.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Multi-drug resistance (MDR) remains a major obstacle in cancer treatment while being heavily dependent on mitochondrial activity and drug efflux. We previously demonstrated that cationic lipids, such as the vitamin E succinate modified octahistidine-octaarginine (VES-HR) conjugate, target mitochondria, resulting in depolarized mitochondria and inhibited drug efflux in MDR breast cancer cells. We hypothesized that the effective cell uptake, efflux inhibition, and mitochondrial depolarization properties of VES-HR would synergistically enhance the toxicity of a pH-sensitive prodrug of doxorubicin (pDox) when co-encapsulated in nanoparticles (NPs). Read More

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http://dx.doi.org/10.1038/s41598-020-65450-xDOI Listing

Participatory practices at work change attitudes and behavior toward societal authority and justice.

Nat Commun 2020 May 26;11(1):2633. Epub 2020 May 26.

420 Peretsman Scully Hall, Department of Psychology, Princeton University, Princeton, NJ, 08544, USA.

Generalized attitudes toward authority and justice are often conceptualized as individual differences that are resistant to enduring change. However, across two field experiments with Chinese factory workers and American university staff, small adjustments to people's experience of participation in the workplace shifted these attitudes one month later. Both experiments randomly assigned work groups to a 20-minute participatory meeting once per week for six weeks, in which the supervisor stepped aside and workers discussed problems, ideas, and goals regarding their work (vs. Read More

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http://dx.doi.org/10.1038/s41467-020-16383-6DOI Listing

Assessing Diaphragmatic Function.

Respir Care 2020 Jun;65(6):807-819

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

The diaphragm is vulnerable to injury during mechanical ventilation, and diaphragm dysfunction is both a marker of severity of illness and a predictor of poor patient outcome in the ICU. A combination of factors can result in diaphragm weakness. Both insufficient and excessive diaphragmatic contractile effort can cause atrophy or injury, and recent evidence suggests that targeting an appropriate amount of diaphragm activity during mechanical ventilation has the potential to mitigate diaphragm dysfunction. Read More

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http://dx.doi.org/10.4187/respcare.07410DOI Listing

Esophageal Manometry.

Respir Care 2020 Jun;65(6):772-792

Center for Acute Respiratory Failure and Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians & Surgeons, New York, New York.

The estimation of pleural pressure with esophageal manometry has been used for decades, and it has been a fertile area of physiology research in healthy subject as well as during mechanical ventilation in patients with lung injury. However, its scarce adoption in clinical practice takes its roots from the (false) ideas that it requires expertise with years of training, that the values obtained are not reliable due to technical challenges or discrepant methods of calculation, and that measurement of esophageal pressure has not proved to benefit patient outcomes. Despites these criticisms, esophageal manometry could contribute to better monitoring, optimization, and personalization of mechanical ventilation from the acute initial phase to the weaning period. Read More

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http://dx.doi.org/10.4187/respcare.07425DOI Listing

Urolithiasis and cystitis associated with Staphylococcus delphini group A and mortality in post-weaning mink kits (Neovison vison).

Vet Microbiol 2020 Jun 5;245:108706. Epub 2020 May 5.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, 1870 Frederiksberg C, Denmark.

Mortality of mink kits represents a significant loss to production. However, causes of post-weaning mortality in mink kits in modern Danish mink production systems are still relatively poorly documented. We performed a cross-sectional mortality study on eight Danish mink farms including 1893 post mortem examinations of mink kits found dead or euthanized. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108706DOI Listing

Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica.

BMC Genomics 2020 May 26;21(1):374. Epub 2020 May 26.

Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, Ontario, Canada.

Background: Bacteriophages are bacterial parasites and are considered the most abundant and diverse biological entities on the planet. Previously we identified 154 prophages from 151 serovars of Salmonella enterica subsp. enterica. Read More

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http://dx.doi.org/10.1186/s12864-020-6765-zDOI Listing

Northern Sea Cucumber (): A Potential Candidate for Functional Food, Nutraceutical, and Pharmaceutical Sector.

Mar Drugs 2020 May 22;18(5). Epub 2020 May 22.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.

Sea cucumber () is the most abundant and widely distributed species in the cold waters of North Atlantic Ocean. contains a wide range of bioactive compounds, mainly collagen, cerebrosides, glycosaminoglycan, chondroitin sulfate, saponins, phenols, and mucopolysaccharides, which demonstrate unique biological and pharmacological properties. In particular, the body wall of this marine invertebrate is the major edible part and contains most of the active constituents, mainly polysaccharides and collagen, which exhibit numerous biological activities, including anticancer, anti-hypertensive, anti-angiogenic, anti-inflammatory, antidiabetic, anti-coagulation, antimicrobial, antioxidation, and anti- osteoclastogenic properties. Read More

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http://dx.doi.org/10.3390/md18050274DOI Listing

Estimating Lower Extremity Running Gait Kinematics with a Single Accelerometer: A Deep Learning Approach.

Sensors (Basel) 2020 May 22;20(10). Epub 2020 May 22.

Menrva Research Group, Schools of Mechatronic Systems Engineering & Engineering Science, Simon Fraser University, Metro Vancouver, BC V5A 1S6, Canada.

Abnormal running kinematics are associated with an increased incidence of lower extremity injuries among runners. Accurate and unobtrusive running kinematic measurement plays an important role in the detection of gait abnormalities and the prevention of injuries among runners. Inertial-based methods have been proposed to address this need. Read More

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http://dx.doi.org/10.3390/s20102939DOI Listing

Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology.

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Clinical Research, Faculty of Infectious & Tropical Disease, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

This review aimed at determining the prevalence and incidence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in Europe. We conducted a primary search in Scopus, PubMed and Web of Science for publications between 1994 and 15 June 2019 (PROSPERO: CRD42017078688). Additionally, we performed a backward-(reference lists) and forward-(citations) search of the works included in this review. Read More

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http://dx.doi.org/10.3390/jcm9051557DOI Listing

Extraction, Antioxidant Capacity, 5-Lipoxygenase Inhibition, and Phytochemical Composition of Propolis from Eastern Canada.

Molecules 2020 May 21;25(10). Epub 2020 May 21.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.

Soxhlet (SE), microwave-assisted (MAE) and ultrasound-assisted (UAE) extraction were compared using ten extraction solvents for their efficiency to extract phenolic and flavonoid antioxidants from Eastern Canada propolis. Extracts were compared for total phenolic (TPC) and total flavonoid (TFC) content, and radical scavenging activities. Anti-inflammatory activity through inhibition of 5-lipoxygenase (5-LO) products biosynthesis in HEK293 cells was also evaluated. Read More

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http://dx.doi.org/10.3390/molecules25102397DOI Listing

Use of Cognitive Aids: Results from a National Survey among Anaesthesia Providers in France and Canada.

Anesthesiol Res Pract 2020 6;2020:1346051. Epub 2020 May 6.

Centre de simulation LabForSIMS, Faculté de médecine Paris Saclay, 94275 Le Kremlin Bicêtre, France.

Introduction: The use of cognitive aids (CAs) during critical events is thought to be useful. However, whether CAs are known and used by French and Canadian anaesthesia providers is not clear.

Methods: A survey was emailed to French and Canadian anaesthesia providers in 2017 through their respective national societies. Read More

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http://dx.doi.org/10.1155/2020/1346051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225858PMC

A Strength-Based Intervention to Increase Participation in Leisure Activities in Children with Neuropsychiatric Disabilities: A Pilot Study.

Occup Ther Int 2020 2;2020:1358707. Epub 2020 Apr 2.

Department of Women's and Children's Health, Karolinska Institute, Solnavägen 1, 171 77 Solna, Stockholm, Sweden.

The aim is to evaluate the feasibility of an intervention model with a client-centered goal-directed approach with the aim to enhance the child's participation in leisure activities, self-efficacy, and activity performance. A pilot intervention using a client-centered goal-directed approach and a single-subject design was performed. Two Swedish boys with neuropsychiatric diagnosis aged 12 and 14 years old were included, and 3 leisure activity goals were identified. Read More

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http://dx.doi.org/10.1155/2020/1358707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154983PMC

Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories.

J Clin Virol 2020 May 13;128:104433. Epub 2020 May 13.

National Microbiology Laboratory (NML), Public Health Agency of Canada (PHAC), Winnipeg, Manitoba, Canada.

With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs and most commercially available methods. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104433DOI Listing

Pediatric Ocular Injuries: A 3-Year Follow-up Study of Patients Presenting to a Tertiary Care Clinic in Canada.

J Pediatr Ophthalmol Strabismus 2020 May;57(3):185-189

Purpose: To identify age groups or activities at risk for ocular injuries to provide parents, sports teams, schools, and hospitals with the appropriate tools for prevention strategies.

Methods: A retrospective chart review was conducted of all trauma-related cases from 2013 to 2015 and data were obtained with the use of an electronic medical record. All patients younger than 18 years who presented to the ophthalmology clinic with traumatic ocular injuries were included. Read More

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http://dx.doi.org/10.3928/01913913-20200326-01DOI Listing

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis.

J Neuroimaging 2020 May 26. Epub 2020 May 26.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background And Purpose: Hereditary diffuse leukoencephalopathy with spheroids (HDLS) and multiple sclerosis (MS) are demyelinating and neurodegenerative disorders that can be hard to distinguish clinically and radiologically. HDLS is a rare disorder compared to MS, which has led to occurrent misdiagnosis of HDLS as MS. That is problematic since their prognosis and treatment differ. Read More

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http://dx.doi.org/10.1111/jon.12725DOI Listing

COVID-19: Safe Guidelines for Breast Imaging During the Pandemic.

Can Assoc Radiol J 2020 May 26:846537120928864. Epub 2020 May 26.

Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

During the COVID-19 pandemic, breast imaging must be performed using safe practices. Balancing the need to avoid delays in the diagnosis of breast cancer while avoiding infection requires careful attention to personal protective equipment and physical distancing and vigilance to maintain these practices. The Canadian Society of Breast Imaging/Canadian Association of Radiologists guideline for breast imaging during COVID-19 is provided based on priority according to risk of breast cancer and impact of delaying treatment. Read More

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http://dx.doi.org/10.1177/0846537120928864DOI Listing

Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome.

Epilepsia 2020 May 26. Epub 2020 May 26.

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Objective: Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults. Although it is commonly related to hippocampal pathology, increasing evidence suggests structural changes beyond the mesiotemporal lobe. Functional anomalies and their link to underlying structural alterations, however, remain incompletely understood. Read More

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http://dx.doi.org/10.1111/epi.16540DOI Listing

Placental histopathology in sickle cell disease: A descriptive and hypothesis-generating study.

Placenta 2020 Apr 17;95:9-17. Epub 2020 Apr 17.

Mount Sinai Hospital, Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Toronto, Canada; University of Toronto, Department of Medicine, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

Introduction: Abnormal placental development is a unifying factor amongst many adverse pregnancy outcomes (APOs) in Sickle Cell Disease (SCD). Our aim was to describe placental histopathologic findings in women with SCD and their relationship with APOs, and to explore the association between antenatal sonographic findings and placental pathology.

Methods: Retrospective single-centre case series of all pregnant women with SCD (January 2000-December 2017), pregnancy beyond 20 weeks' gestation, and available placenta histopathology. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.003DOI Listing

The Lack of Adequate Scientific Evidence Regarding Physician-assisted Death for People with Psychiatric Disorders Is a Danger to Patients.

Can J Psychiatry 2020 May 26:706743720928658. Epub 2020 May 26.

Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/0706743720928658DOI Listing

Knowledge and Understanding of the Safety and Efficacy Aspects of BRIDION Among Canadian Anesthesiologists.

Drugs Real World Outcomes 2020 May 25. Epub 2020 May 25.

Merck & Co. Inc., Kenilworth, NJ, USA.

Background: BRIDION (sugammadex sodium) is an agent for the reversal of neuromuscular blockade (NMB) induced by rocuronium and vecuronium in general anesthesia. Following the approval of sugammadex in Canada (February 2016), Health Canada required a survey to assess the knowledge and understanding of the safety and efficacy aspects of sugammadex among anesthesiologists in Canada.

Objective: Our objective was to evaluate how well the anesthesiologists in Canada understood the safety and efficacy aspects of sugammadex. Read More

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http://dx.doi.org/10.1007/s40801-020-00200-zDOI Listing

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.

Nat Cell Biol 2020 May 25. Epub 2020 May 25.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.

The dynamin GTPase is known to bundle actin filaments, but the underlying molecular mechanism and physiological relevance remain unclear. Our genetic analyses revealed a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo. Using biochemistry, total internal reflection fluorescence microscopy, electron microscopy and cryo-electron tomography, we show that dynamin bundles actin while forming a helical structure. Read More

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http://dx.doi.org/10.1038/s41556-020-0519-7DOI Listing

Assessments of frailty in bladder cancer.

Urol Oncol 2020 May 22. Epub 2020 May 22.

Division of Urology. Electronic address:

Background And Aims: The incidence of frailty is increasing as the population ages, which has important clinical implications given the associations between frailty and poor outcomes in the bladder cancer population. Due to a multi-organ system decline and decreased physiologic reserve, frail patients are vulnerable to stressors of disease and have poorer mortality and morbidity rates than their nonfrail peers. The association between frailty and poor outcomes has been documented across multiple populations, including radical cystectomy, creating a need for frailty assessments to be used preoperatively for risk stratification. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.036DOI Listing

Access to allied health care services in Canadian interdisciplinary complex nerve injury programs.

Can J Neurol Sci 2020 May 26:1-12. Epub 2020 May 26.

British Columbia Centre for Complex Nerve Injury, Vancouver, British Columbia, Canada.

Nerve transfer surgery (NT) for patients with nerve and spinal cord injuries can result in dramatic functional improvements. As a result, interdisciplinary complex nerve injury programs (CNIPs) have been established in many Canadian centres, providing electrodiagnostic and surgical consultations in a single encounter. We sought to determine which allied health care services are included in Canadian CNIPs, at the 3rd Annual Canadian Peripheral Nerve Symposium. Read More

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http://dx.doi.org/10.1017/cjn.2020.98DOI Listing

Personalized and graph genomes reveal missing signal in epigenomic data.

Genome Biol 2020 May 25;21(1):124. Epub 2020 May 25.

Human Genetics, McGill University, Montreal, QC, Canada.

Background: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize that using a generic reference could lead to incorrectly mapped reads and bias downstream results.

Results: We show that accounting for genetic variation using a modified reference genome or a de novo assembled genome can alter histone H3K4me1 and H3K27ac ChIP-seq peak calls either by creating new personal peaks or by the loss of reference peaks. Read More

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http://dx.doi.org/10.1186/s13059-020-02038-8DOI Listing

Exploring patient-reported barriers to advance care planning in family practice.

BMC Fam Pract 2020 May 25;21(1):94. Epub 2020 May 25.

Department of Family Medicine, McMaster University, DBHSC 100 Main Street West, 5th floor, Hamilton, Ontario, L8P 1H6, Canada.

Background: Although patient-centred care has become increasingly important across all medical specialties, when it comes to end of life care, research has shown that treatments ordered are not often concordant with people's expressed preferences. Patient and family engagement in Advance Care Planning (ACP) in the primary care setting could improve the concordance between patients' wishes and the healthcare received when patients cannot speak for themselves. The aim of this study was to better understand the barriers faced by older patients regarding talking to their family members and family physicians about ACP. Read More

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http://dx.doi.org/10.1186/s12875-020-01167-0DOI Listing

A multi-stakeholder approach in optimising patients' needs in the benefit assessment process of new metastatic breast cancer treatments.

Breast 2020 May 10;52:78-87. Epub 2020 May 10.

Canadian Breast Cancer Network, Ottawa, ON, Canada.

There is a growing understanding as science evolves that different cancer types require different approaches to treatment evaluation, especially in the metastatic stages. The introduction of new metastatic breast cancer (MBC) treatments may be hindered by several elements, including the availability of relevant evidence related to disease-specific outcomes, the benefit assessment process around the evaluation of the clinical benefit and the patients' need of new treatments. The Steering Committee (SC) found that not all issues relevant to MBC patients are consistently considered in the current benefit assessment process of new treatments. Read More

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http://dx.doi.org/10.1016/j.breast.2020.04.011DOI Listing

The impact of pre-procedure heart rate on adverse clinical outcomes in patients undergoing percutaneous coronary intervention: Results from a 2-year follow-up of the GLOBAL LEADERS trial.

Atherosclerosis 2020 Apr 28;303:1-7. Epub 2020 Apr 28.

Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

Background And Aims: The prognostic impact of pre-procedure heart rate (PHR) following percutaneous coronary intervention (PCI) has not yet been fully investigated. This post-hoc analysis sought to assess the impact of PHR on medium-term outcomes among patients having PCI, who were enrolled in the "all-comers" GLOBAL LEADERS trial.

Methods And Results: The primary endpoint (composite of all-cause death or new Q-wave myocardial infarction [MI]) and key secondary safety endpoint (bleeding according to Bleeding Academic Research Consortium [BARC] type 3 or 5) were assessed at 2 years. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.04.010DOI Listing

The experiences of diploma registered nurses returning to undergraduate study in Qatar: A descriptive qualitative study.

Nurse Educ Today 2020 Apr 29;91:104456. Epub 2020 Apr 29.

Institute of Clinical Sciences, School of Nursing, University of Birmingham, Birmingham, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address:

Background: Qatar aspires to provide world-class healthcare comparable with Western countries. Compelling evidence demonstrating the positive effects of bachelor of nursing (BN) educated nurses on patient outcomes is creating a global demand for these graduates, particularly in contexts such as Qatar where historically RN-to-BN programs were unavailable.

Objective: The aim of this study was to examine the return to education experiences of diploma educated registered nurses (RNs) undertaking a bachelor program. Read More

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http://dx.doi.org/10.1016/j.nedt.2020.104456DOI Listing

A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services.

J Allergy Clin Immunol Pract 2020 May 22. Epub 2020 May 22.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

In early 2020, the first US and Canadian cases of the novel SARS-CoV-2 infection were detected. In the ensuing months, there has been rapid spread of the infection. In March 2020, in response to the virus, state/provincial and local governments instituted shelter-in-place orders, and non-essential ambulatory care was significantly curtailed, including allergy/immunology services. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.012DOI Listing

High subzero cryofixation: A technique for observing ice within tissues.

Cryobiology 2020 May 22. Epub 2020 May 22.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2R3, Canada; Centre for Innovation, Canadian Blood Services, 8249 114th Street, Edmonton, AB, T6G 2R8, Canada. Electronic address:

While various fixation techniques for observing ice within tissues stored at high sub-zero temperatures currently exist, these techniques require either different fixative solution compositions when assessing different storage temperatures or alteration of the sample temperature to enable alcohol-water substitution. Therefore, high-subzero cryofixation (HSC), was developed to facilitate fixation at any temperature above -80 °C without sample temperature alteration. Rat liver sections (1 cm) were frozen at a rate of -1 °C/min to -20 °C, stored for 1 h at -20 °C, and processed using classical freeze-substitution (FS) or HSC. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2020.05.008DOI Listing

The effect of laboratory requisition modification, audit and feedback with academic detailing or both on utilization of blood urea testing in family practice in Newfoundland, Canada.

Clin Biochem 2020 May 22. Epub 2020 May 22.

Clinical Epidemiology & Nephrology, Faculty of Medicine, Memorial University of Newfoundland, Canada. Electronic address:

Objectives: Measuring blood urea at the same time as serum creatinine in stable ambulatory patients in family practice is largely unnecessary. The objective was to assess the relative impact of changing the laboratory requisition versus audit and feedback and academic detailing on the volume of orders for blood urea. Design and Methods A natural experiment was observed over the period April 2015 to March 2018 in the Canadian province of Newfoundland where three health regions had different approaches to trying to reduce such urea testing. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2020.05.008DOI Listing