1,996 results match your criteria Canadian Journal Of Veterinary Research-revue Canadienne De Recherche Veterinaire[Journal]


Pilot study investigating the feasibility of mitral valve repair without aortic cross-clamping and cardioplegia.

Can J Vet Res 2020 Apr;84(2):159-162

Veterinary Medical Center North, University of Minnesota, 1365 Gortner Avenue, St. Paul, Minnesota 55108, USA (Gordon-Evans); University of Minnesota Medical School, 420 Delaware Street SE, Mayo Mail Code 195, Minneapolis, Minnesota 55455, USA (Carney, Lahti, Bianco).

There is evidence that perfusing the heart with a heart and lung machine is less injurious than cross-clamping the aorta and administering cardioplegia during cardiac surgery. Although mitral valve replacement has been carried out without aortic cross-clamping and cardioplegia, it has been stated that cross-clamping is necessary in order to maintain visualization and a motionless surgical field for mitral valve repair. The purpose of this study was to determine the surgical feasibility of mitral valve repair without cross-clamping the aorta and using cardioplegia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088510PMC

Duration of immunity after rabies vaccination in dogs: The Rabies Challenge Fund research study.

Can J Vet Res 2020 Apr;84(2):153-158

Hemopet, 11561 Salinaz Avenue, Garden Grove, California 92843, USA (Dodds); Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA [Larson, Schultz (Emeritus)]; Christine Road, Alna, Maine 04535, USA (Christine).

A prospective study of 65 research beagles kept in a rabies-free environment was undertaken to determine the duration of immunity after they received licensed rabies vaccines. The eventual goal was to extend mandated rabies booster intervals to 5 or 7 years and help reduce the risk of vaccine-associated adverse events. Three groups of dogs were vaccinated with 1 of 2 commercial rabies vaccines or saline at 12 and 15 weeks of age. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088826PMC

L-lactate in cerebrospinal fluid can be used as a biomarker of encephalitis in cattle.

Can J Vet Res 2020 Apr;84(2):146-152

Animal Health and Production Science, Centro de Ciências Agrárias, Universidade Estadual de Londrina, Campus Universitário, Cx. Postal 10011, Londrina, PR, 86057-970, Brazil (Curti); Universidade do Norte do Paraná, Av. Paris 675, Londrina, PR, 86041120, Brazil (Queiroz); Department of Veterinary Clinics, Centro de Ciências Agrárias, Universidade Estadual de Londrina, Campus Universitário, Cx. Postal 10011, Londrina, PR, 86057-970, Brazil (Pereira, Anjos, Lisbôa); Department of Preventive Veterinary Medicine, Centro de Ciências Agrárias, Universidade Estadual de Londrina, Campus Universitário, Cx. Postal 10011, Londrina, PR, 86057-970, Brazil (Flaiban).

Cerebrospinal fluid (CSF) changes are significant for antemortem diagnoses of some neurological diseases. The aim of this study was to evaluate if the concentration of L-lactate in CSF could be used to differentiate healthy from encephalitic cattle. Cerebrospinal fluid samples from healthy cattle ( = 10) and from those naturally affected by rabies ( = 15), bovine herpesvirus type 5 meningoencephalitis ( = 16), histophilosis ( = 6), or bacterial encephalitis ( = 4), including 1 case of listeriosis, were collected and analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088516PMC

Bile composition of healthy cats and cats with suspected hepatobiliary disease using point-of-care analyzers: A prospective preliminary study.

Can J Vet Res 2020 Apr;84(2):138-145

Department of Clinical Sciences (Huvé, O'Toole, Fontaine, Bélanger) and Department of Pathology and Microbiology (Gara-Boivin), Faculty of Veterinary Medicine, University of Montreal, C.P. 5000, Saint-Hyacinthe, Quebec J2S 7C6.

Although hepatobiliary disease is common in cats, little is known about the bile composition in either these diseased states or in healthy cats. The objectives of this study were to evaluate several analytes from the bile of healthy cats and to investigate the usefulness of measuring these variables to predict bacterial cholangitis. Cats were prospectively enrolled and divided into 3 groups: 21 healthy cats (group 1) and 14 cats with suspected hepatobiliary disease: 9 without bacterial biliary infection (group 2) and 5 with bacterial biliary infection (group 3). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088509PMC

Effects of laser power, wavelength, coat length, and coat color on tissue penetration using photobiomodulation in healthy dogs.

Can J Vet Res 2020 Apr;84(2):131-137

Department of Comparative, Diagnostic, and Population Medicine, University of Florida College of Veterinary Medicine, 2015 SW 16th Avenue, PO Box 100123, Gainesville, Florida 32608, USA (Hochman-Elam, Shmalberg); Department of Surgery, Division of Biostatistics, University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA (Heidel RE).

Photobiomodulation is an accepted regenerative medicine treatment modality used to stimulate tissue repair, mediate inflammation, and improve mobility in humans and animals. The objective of this study was to assess the influence of laser power and wavelength, coat length and color, and shaving on photon delivery by therapeutic laser in dogs. Forty-seven dogs of various breeds and coat colors (17 black, 15 brown, and 15 white) and with varying coat lengths were assessed with 2 commercially available veterinary lasers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088515PMC

Assessment of diastolic function using mitral flow propagation velocity in cats.

Can J Vet Res 2020 Apr;84(2):124-130

Laboratory of Surgery 1, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

The objectives of this study were to investigate the usefulness of mitral flow propagation velocity (Vp) in cats by evaluating the effect of the flow pattern summation and evaluation of Vp variables in cats with hypertrophic cardiomyopathy (HCM). Healthy cats were categorized into summation (Sum) and separation (Sepa) groups to evaluate the effects of the flow pattern summation on Vp. Cats with HCM were categorized into HCM left atrial (LA) (-), LA (+), and LA (++) groups according to the degree of LA enlargement to investigate the feasibility of Vp. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088511PMC

effects of taurolidine alone and in combination with mitoxantrone and/or piroxicam on canine transitional cell carcinoma.

Can J Vet Res 2020 Apr;84(2):115-123

Flint Animal Cancer Center, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA.

The objective of this study was to evaluate taurolidine as a therapy for transitional cell carcinomas in canine patients. Transitional cell carcinoma (TCC) is the most common cancer of the urinary bladder in dogs and accounts for approximately 2% of reported malignancies in this species. There is no cure for this neoplasm and most dogs are lost from complications associated with progression of the local disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088828PMC

Cardiovascular and respiratory effects of carbon dioxide pneumoperitoneum in the domestic rabbit .

Can J Vet Res 2020 Apr;84(2):108-114

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

The objective of this study was to evaluate the effect of intra-abdominal pressure (IAP) on cardiorespiratory parameters during pneumoperitoneum with carbon dioxide in domestic rabbits. Six juvenile female New Zealand white rabbits were assigned to randomized sequences of IAP (0, 4, 8 mmHg) in a crossover study. The following parameters were measured at each IAP: direct arterial blood pressure (ABP); cardiac output, (CO), cardiac index, and stroke volume index (CI, SVI); heart rate; end-tidal carbon dioxide (ETCO); arterial blood gases (PaCO, PaO); peak inspiratory pressure (PIP); and peripheral oxygen saturation (SpO). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088512PMC

Respiratory and hemodynamic effects of 2 protocols of low-dose infusion of dexmedetomidine in dogs under isoflurane anesthesia.

Can J Vet Res 2020 Apr;84(2):96-107

Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production (Di Bella, Skouropoulou, Stabile, Lacitignola, Valentini, Crovace, Staffieri) and Section of Anesthesia and Intensive Care (Grasso), "Aldo Moro" University of Bari, Bari, Italy; Department of Surgery, University of Agriculture Sciences and Veterinary Medicine, Cluj-Napoca, Romania (Muresan).

The aim of this study was to evaluate the respiratory and hemodynamic effects of a low-dose dexmedetomidine infusion [1 μg/kg body weight (BW) per hour], with or without a loading dose (1 μg/kg BW), in dogs under isoflurane anesthesia. Thirty dogs were premedicated with methadone [0.3 mg/kg BW intramuscular (IM)], induced with propofol intravenous (IV) and maintained with isoflurane (1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088514PMC

The effect of inspired oxygen concentration on oxidative stress biomarkers in dogs under inhalation anesthesia.

Can J Vet Res 2020 Apr;84(2):91-95

The United Graduate School of Veterinary Science, Gifu University, Yanagido 1-1, Gifu, Gifu, 501-1193, Japan (Chongphaibulpatana); Laboratory of Veterinary Diagnostic Radiology, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Chongphaibulpatana, Kumagai, Katayama, Uzuka); Laboratory of Small Animal Surgery, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Fukui).

This study investigated oxidative stress biomarkers at 3 different oxygen concentrations in dogs under general anesthesia to determine whether high-concentration oxygen increases oxidative stress. Six healthy beagles were randomly assigned to receive 3 anesthesia protocols (inhalation of 40%, 60%, and 100% oxygen) during 3 hours of general anesthesia with sevoflurane, with at least one week in between each protocol. For each experiment, blood samples were collected at 0, 3, 6, and 24 hours after inhalation of oxygen. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088964PMC

Changes in CO-oximetry values and pulse oximetry in isoflurane-anesthetized dogs with and without nitrous oxide.

Can J Vet Res 2020 Apr;84(2):83-90

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4 (Jones, Duke-Novakovski); School of Public Health, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4 (Feng).

Concentrations of 64% to 70% nitrous oxide (NO) provide intra-operative analgesia. Clinically, pulse oximeter estimation (SpO) of oxygen (O) hemoglobin saturation (SaO) was observed to decrease with NO. Absorption atelectasis from breathing O was thought to decrease arterial partial pressure of O (PaO) below 70 mmHg and reduce SaO and SpO when NO was used. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088513PMC

Erratum.

Authors:

Can J Vet Res 2020 04;84(2):82

[This corrects the article on p. 149 in vol. 83, PMID: 31097877. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088508PMC

Alterations in serum protein electrophoresis profiles during the acute phase response in dogs with acute pancreatitis.

Can J Vet Res 2020 Jan;84(1):74-78

College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea (Yoon, Kang, Park); Gyeongsang National University Hospital, Jinju 52727, Korea (Kim); College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea (Yu).

The quantification of serum proteins is a useful tool for diagnosing and monitoring various diseases that involve changes in the concentrations of these proteins. As canine acute pancreatitis (AP) accompanies the systemic inflammatory response syndrome, serum proteins such as C-reactive protein (CRP) have been used as inflammatory markers for dogs with AP. The goal of this study was to investigate the overall profiles of serum proteins by serum protein electrophoresis (SPE) and to determine the concentration of acute phase proteins (APPs) in dogs with AP in order to better understand serum protein profiles as diagnostic markers in these dogs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923814PMC
January 2020

Antioxidative enzyme activity and total antioxidant capacity in serum of dogs with degenerative mitral valve disease.

Can J Vet Res 2020 Jan;84(1):67-73

Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats (Michałek, Cepiel, Noszczyk-Nowak) and Department of Food Hygiene and Consumer Health (Tabiś), Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wroclaw, Poland.

This study was designed to evaluate the antioxidative status of serum by measuring its total antioxidant capacity, as well as the antioxidant enzyme activity (superoxide dismutase, catalase, and glutathione reductase), in dogs with various stages of degenerative mitral valve disease (DMVD) compared to healthy controls. In total, 71 client-owned dogs in different stages of DMVD, which included healthy controls, took part in the study. Following an anamnesis, clinical examination, standard transthoracic echocardiograpic examination, chest X-ray, complete blood (cell) count, and serum biochemistry, dogs were divided into 2 study groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923815PMC
January 2020

Determination of urokinase-type plasminogen activator serum levels in healthy and oncologic cats.

Can J Vet Res 2020 Jan;84(1):60-66

Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório).

The urokinase plasminogen activator system (uPAS) has been poorly investigated in veterinary oncology. The aim of this study was to determine uPA serum concentrations in healthy and oncologic cats to understand the potential value of uPA as a cancer biomarker. Serum samples were collected from 19 healthy cats and 18 cats with spontaneous malignant neoplasms and uPA was measured through a specific enzyme-linked immunosorbent assay kit. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923816PMC
January 2020

Effects of a single paracetamol injection on the sevoflurane minimum alveolar concentration in dogs.

Can J Vet Res 2020 Jan;84(1):37-43

Department of Animal Medicine and Surgery, School of Veterinary Medicine, Complutense University of Madrid, Av. Puerta de Hierro, s/n, 28040 Madrid, Spain (González-Blanco, Canfrán, Gómez de Segura, Aguado); Comparative Medicine Unit, Fundación Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, 3 Melchor Fernández Almagro St., 28029 Madrid, Spain (Mota).

This study aimed to determine the effect of a single injection of paracetamol on the sevoflurane minimum alveolar concentration (MAC) response to noxious mechanical stimulation. Seven healthy adult beagles were enrolled in a prospective, randomized, blinded, crossover experimental study. Anesthesia was induced with propofol [11. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921988PMC
January 2020

Comparison of 3 intraosseous catheter sites and methods of determining placement success in cadaver rabbits.

Can J Vet Res 2020 Jan;84(1):33-36

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, 55 Willard Street N, North Grafton, Massachusetts 01536, USA.

The study goals were to determine if intraosseous (IO) catheters can be placed with greater success into the humerus, femur, or tibia of cadaver rabbits, and to evaluate the accuracy of perceived success (PS) and objective clinical success (OCS) criteria against true intramedullary catheterization confirmed by fluoroscopy. This was a prospective study utilizing 12 rabbit cadavers. Twenty-two participants attempted IO catheter placement at 3 sites. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921990PMC
January 2020

Fluoroscopic and radiographic assessment of variations in tracheal height during inspiration and expiration in healthy adult small-breed dogs.

Can J Vet Res 2020 Jan;84(1):24-32

Tufts University Cummings School of Veterinary Medicine, Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Scherf); Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, 3200 rue Sicotte, Saint-Hyacinthe, Quebec J2S 2M2 (Masseau, Bua, Beauchamp, Dunn).

The objective of this study was to document tidal variations in tracheal height during normal respiration in 19 healthy adult (> 1 y old) small-breed dogs (< 10 kg) using fluoroscopy and radiography. Each dog underwent tracheal fluoroscopic examination on inspiration and expiration while in a standing position (F-S) and in right lateral recumbency (F-RL), followed by radiographic projections obtained in right lateral recumbency. The percent variation in tracheal height during maximal inspiration and expiration was determined at 3 different locations [cervical region (CR), thoracic inlet (TI), and intrathoracic (IT) region]. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921987PMC
January 2020

Prevalence and mutation analysis of the spike protein in feline enteric coronavirus and feline infectious peritonitis detected in household and shelter cats in western Canada.

Can J Vet Res 2020 Jan;84(1):18-23

Department of Ecosystem and Public Health (McKay, Davies, van der Meer) and Diagnostic Services Unit (Davies), Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta; Department of Veterinary Pathology (Meachem) and Department of Small Animal Clinical Sciences (Snead), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan; Meow Foundation, Calgary, Alberta (Brannen); Fish Creek Pet Hospital, Calgary, Alberta (Mutlow); Wild Rose Cat Clinic, Calgary, Alberta (Ruelle).

Feline infectious peritonitis (FIP) is a fatal disease for which no simple antemortem diagnostic assay is available. A new polymerase chain reaction (PCR) test has recently been developed that targets the spike protein region of the FIP virus (FIPV) and can identify specific mutations (M1030L or S1032A), the presence of which indicates a shift from feline enteric coronavirus (FeCV) to FIPV. This test will only be useful in the geographical region of interest, however, if the FIP viruses contain these mutations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921991PMC
January 2020

Serum paraoxonase-1 activity in tail and mammary veins of ketotic dairy cows.

Can J Vet Res 2020 Jan;84(1):79-81

Department of Veterinary Herd Health, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Fukumori, Nakada, Oikawa); Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut Governate 71515, Egypt (Elsayed); Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5 (Oba); Saroma Veterinary Clinical Center, Okhotsk Agricultural Mutual Aid Association, Saroma, Hokkaido 093-0507, Japan (Tachibana).

The objective of this study was to evaluate the association between ketonemia and serum paraoxonase-1 (PON1), malondialdehyde (MDA), and other blood components in tail and mammary veins of dairy cows. Forty-two Holstein dairy cows with decreased feed intake were divided into HIGH (≥ 1.2 mM; = 31) and LOW (< 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923817PMC
January 2020

Differences in the relative counts of peripheral blood lymphocyte subsets in various age groups of pigs.

Can J Vet Res 2020 Jan;84(1):52-59

Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland.

The aim of the study was to determine age-related changes in peripheral blood lymphocytes in pigs. Previous studies looking at age-related differences in lymphocyte subsets in porcine blood have not established reference ranges for these parameters. Moreover, most studies have concentrated on the dynamic changes in the first months of life, failing to continue observations in older animals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921992PMC
January 2020

Correlation of activity data in normal dogs to distance traveled.

Can J Vet Res 2020 Jan;84(1):44-51

University of Minnesota, College of Veterinary Medicine, Department of Veterinary Clinical Sciences, 1365 Gortner Avenue, St. Paul, Minnesota 55108, USA (Eskander, Evans, Conzemius); Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA (Barbar, Enomoto, Lascelles); Center for Pain Research and Innovation, UNC School of Dentistry, 385 South Columbia Street, Chapel Hill, North Carolina 27599, USA (Lascelles); Center for Translational Pain Research, Department of Anesthesiology, Duke University, 134 Research Drive, Durham, North Carolina 27710, USA (Lascelles).

The objective of this study was to explore the mathematical relationships between independent variables (patient morphometrics and treadmill speed) and dependent variables (accelerometer or pedometer output) when evaluating data from accelerometers and pedometers in dogs. Twenty dogs took part in 3 randomized activities, consisting of exercise on a treadmill at 1.0, 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921993PMC
January 2020

Carbapenemase-producing in animals and methodologies for their detection.

Can J Vet Res 2020 Jan;84(1):3-17

Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario NIG 2W1.

Carbapenemase-producing bacteria are difficult to treat and pose an important threat for public health. Detecting and identifying them can be a challenging and time-consuming task. Due to the recent rise in prevalence of infections with these organisms, there is an increased demand for rapid and accurate detection methods. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921994PMC
January 2020

Three-dimensional kinematic evaluation of Tightrope CCL in a canine cranial cruciate deficient stifle model.

Can J Vet Res 2019 Oct;83(4):317-321

Faculté de médecine vétérinaire, Département de sciences cliniques, (Laugier); Départment de sciences cliniques, GREPAQ, Faculté de médecine vétérinaire, OA research unit CRCHUM (Lussier), Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe, Quebec J2S 2M2; Research Center (Tremblay), École de technologie supérieure, Department of mechanical engineering, Research Center (Petit, Levasseur), Sacré-Coeur Hospital, Montréal; École de technologie supérieure, Montréal (Grignon-Lemieux).

The impact of surgical correction of cranial cruciate ligament-deficient stifles (CCDS) on the 3-dimensional (3D) kinematics of the canine stifle has been sparsely evaluated. Tightrope (TR) cranial cruciate ligament (CCL) has been proposed to restore baseline 3D kinematics in CCDS by using isometric points. We hypothesized that TR would restore baseline 3D kinematics of the stifle in our model. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753885PMC
October 2019

Effect of vaccination of pregnant beef heifers on the concentrations of serum IgG and specific antibodies to bovine herpesvirus 1, bovine viral diarrhea virus 1, and bovine viral diarrhea virus 2 in heifers and calves.

Can J Vet Res 2019 Oct;83(4):313-316

Department of Clinical Sciences (Reppert, Robinson, Wick), Department of Diagnostic Medicine/Pathobiology (Cernicchiaro), College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA; Department of Animal Science and Industry, College of Agriculture, Kansas State University, Manhattan, Kansas 66506, USA (Weaber); Department of Clinical Science, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Chamorro); Department of Veterinary Microbiology, College of Veterinary Medicine, University of Saskatchewan S7N 5B4 (Haines); The Saskatchewan Colostrum Company, Saskatoon, Saskatchewan S7N 5B4 (Haines).

The objective of this study was to evaluate the effect of late-gestation vaccination of beef heifers with 2 doses of a killed-virus (KV) vaccine containing bovine herpesvirus 1 (BoHV-1), bovine viral diarrhea virus 1 (BVDV-1), and bovine viral diarrhea virus 2 (BVDV-2) on the serum concentrations of antibody against BoHV-1, BVDV-1, and BVDV-2 in heifers and their calves and on the IgG concentration in the calves. Of the 47 pregnant beef heifers selected, 26 received 2 doses of the vaccine at 6.5 to 8 mo of gestation (at pregnancy check), and 21 received 2 doses of saline. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753975PMC
October 2019

Feasibility of a novel 3-dimensional mathematical algorithmic computation of feline bladder volumes using point-of-care longitudinal and transverse cysto-colic ultrasonographic images.

Can J Vet Res 2019 Oct;83(4):298-312

Department of Clinical Studies, Ontario Veterinary College (Yiew, Clarke, Bateman), Department of Mathematics and Statistics, College of Engineering and Physical Science (Willms), University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

Conventional geometric formulas for estimating bladder volume assume that bladders have a perfectly uniform spheroid geometry. Bladders are often irregularly shaped, however, especially when under-filled or distorted by a full colon, which results in inaccurate ultrasonographic linear measurements and volume estimation. This pilot study investigates the feasibility, inter-observer reliability (reproducibility), robustness, and agreement of a novel 3-dimensional bladder volume computation method using bladder circumference tracing compared to a published feline linear bladder dimension formula. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753888PMC
October 2019
1 Read

Veterinarians' attitudes towards use of nutraceuticals.

Can J Vet Res 2019 Oct;83(4):291-297

Auburn University College of Veterinary Medicine, 1010 Wire Road Auburn, Alabama 36832, USA.

The objective of this study was to assess veterinarians' understanding of nutraceutical use in humans and companion animals and their motivation and circumstances for recommending nutraceuticals to clients. We administered a cross-sectional survey to veterinarians attending continuing education sessions at the University of Georgia (USA) College of Veterinary Medicine from 2012 to 2015 (N = 126). Information regarding veterinarians' age, year of graduation, practice focus, and typical approaches to nutraceutical use was compiled from the returned surveys. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753883PMC
October 2019
1 Read

Comparison of hematologic and biochemical reference values in specific-pathogen-free 1-month-old Yorkshire pigs and Yorkshire-Landrace crossbred pigs.

Can J Vet Res 2019 Oct;83(4):285-290

Department of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, Heilongjiang Province, P.R. China (R. Li, Wang, Zhang, Liu); Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China (R. Li, Liu); Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China (C. Li, Xia, Chen, Lu).

Analysis of hematologic and biochemical values in pigs is an important basis for biomedical research and veterinary clinical diagnosis. Reference values for specific-pathogen-free (SPF) 1-month-old Yorkshire (Y) pigs and Yorkshire-Landrace crossbred (YL) pigs are limited. The present research aimed to describe and compare the reference values for hematologic and biochemical parameters in such pigs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753882PMC
October 2019
1 Read

Pharmacodynamic assessment of canine T-lymphocyte proliferation: Responses to dexamethasone, cyclosporine, mycophenolic acid, and the active metabolite of leflunomide.

Can J Vet Res 2019 Oct;83(4):279-284

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, Missouri 65211, USA (Grobman, Bishop, Rindt, Reinero); Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74078-2042, USA (Nafe).

A lack of understanding of specific immune defects underlying canine immune-mediated diseases hampers optimal therapy. Failure to tailor treatment to an individual's immune abnormality can result in lack of efficacy, secondary complications, added expense, and drug-potentiated adverse effects. We adopted a small-volume whole-blood flow cytometric assay to determine the effect of immunosuppressant drugs on T-lymphocyte proliferation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753887PMC
October 2019

Acute-phase protein profile in horses subjected to different exercise protocols.

Can J Vet Res 2019 Oct;83(4):272-278

São Paulo State University (UNESP), School of Veterinary Medicine and Animal Science (FMVZ), Department of Veterinary Clinical Sciences, Rua Prof. Doutor Walter Mauricio Correa, s/n bairro UNESP, Botucatu Campus, SP Botucatu, São Paulo 18618.618-681, Brazil.

High-intensity exercise can be associated with the occurrence of muscle injury, as well as the induction of an acute-phase response (APR). The present study aims to investigate the synthesis and profile of serum proteins in horses before and after participating in 2 different exercise protocols and to relate this profile to the presence or absence of muscular injury caused by exercise. Ten purebred Arabian ( = 5) and Criollo ( = 5) horses were subjected to 2 different tests on a treadmill, one consisting of short-duration and rapid-acceleration training (TRA) that was mostly anerobic and the other of long-duration and slow-acceleration training (TLD) that was predominantly aerobic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753884PMC
October 2019

Stability of epidermal growth factor, fibronectin, and alpha-2-macroglobulin in canine serum under different storage conditions.

Can J Vet Res 2019 Oct;83(4):267-271

Department of Clinical Sciences (Briffod, Vanore) and Department of Microbiology and Pathology (Bédard), Faculty of Veterinary Medicine, University of Montreal, 3200 rue Sicotte, St-Hyacinthe, Quebec J2S 2M2.

The objective of this study was to assess whether concentrations of epidermal growth factor (EGF), fibronectin, and alpha(α)-2-macroglobulin in canine serum remain stable under different storage conditions. Serum was obtained from 10 adult dogs and stored for 7 d at room temperature (RT) and at 4°C and for 1, 3, and 6 mo at -20°C. Bacterial cultures of serum were carried out after 7 d at 4°C and at RT. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753891PMC
October 2019

Protective efficacy of a vaccine using a -based delivery system expressing Omp3b, BCSP31, and SOD proteins against brucellosis in Korean black goats.

Can J Vet Res 2019 Oct;83(4):261-266

Veterinary Public Health, College of Veterinary Medicine, Chonbuk National University, Gobong-ro 79, Iksan, Jeollabuk-do, Republic of Korea.

This study aimed to assess the protective efficacy of a novel vaccine formulation in goats. Twenty black goats were separated into 2 groups. Group A was injected with 3. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753886PMC
October 2019
2 Reads

Effect of nursery feeding program on serum haptoglobin, growth performance, and carcass characteristics of pigs reared on commercial farms.

Can J Vet Res 2019 Oct;83(4):255-260

Department of Animal Biosciences (Reinhardt, Shoveller, Huber, de Lange), Department of Population Medicine (Farzan), University of Guelph, Ontario N1G 2W1.

A total of 774 pigs were enrolled in 13 cohorts across 7 commercial farms to examine the effect of nursery feeding program on serum haptoglobin, subsequent growth performance, and carcass characteristics of finishing pigs. Pigs were weaned [23.4 ± 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753890PMC
October 2019

Effectiveness of a commercial porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts.

Can J Vet Res 2019 Oct;83(4):248-254

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

The objective of the present study was to evaluate the efficacy of a commercial porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts. Gilts were vaccinated intramuscularly 56 and 35 days antepartum (on days 58 and 79 of gestation) and challenged intranasally 21 days antepartum (on day 93 of gestation) with PRRSV-1 or PRRSV-2. Regardless of the challenge strain's genotype, the vaccinated gilts carried their pregnancies to term and farrowed between days 114 and 115 of gestation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753889PMC
October 2019
1 Read

Vesicular disease in pigs inoculated with a recent Canadian isolate of Senecavirus A.

Can J Vet Res 2019 Oct;83(4):242-247

National Centre for Foreign Animal Disease (NCFAD), Canadian Food Inspection Agency, Winnipeg, Manitoba R3C 1B2.

The objective of this study was to investigate whether a virulent Canadian isolate of Senecavirus A (SVA) causes idiopathic vesicular disease (IVD) in pigs. Senecavirus A, which was first isolated in the United States in 2002 as Seneca Valley Virus, was linked to cases of porcine idiopathic vesicular disease in Canada in 2007 and in the United States in 2010. Since 2014, SVA outbreaks in Brazil, the US, Canada, China, Thailand, and Colombia point to an expanding global distribution and the need to study the pathogenicity of the virus. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753976PMC
October 2019

Effects of 3 morphine doses, in combination with acepromazine, on sedation and some physiological parameters in dogs.

Can J Vet Res 2019 Jul;83(3):235-240

School of Veterinary Medicine, University of Vila Velha, Vila Velha, ES, Brazil.

This study evaluated the effects of 3 morphine doses combined with acepromazine, on sedation and physiological parameters in 5 clinically healthy dogs. Four treatments were administered intramuscularly in a randomized, blinded, crossover design: acepromazine, 0.05 mg/kg, alone (ACP) and acepromazine plus morphine at doses of 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587885PMC

Investigating the ability of methicillin-resistant isolates from different sources to adhere to canine and human corneocytes.

Can J Vet Res 2019 Jul;83(3):231-234

Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok 10330, Thailand (Phumthanakorn, Prapasarakul); Diagnosis and Monitoring of Animal Pathogens Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok 10330, Thailand (Prapasarakul).

Assays were done to assess the ability of 5 methicillin-resistant (MRSP) isolates from difference sources to adhere to canine and human corneocytes. Cell wall-associated (CWA) protein gene profiles were examined to look for associations with adherence. Five MRSP strains were studied: 3 with the same CWA protein gene profile (14 genes) and belonging to sequence type (ST) 45 were isolated from a dog, a human, and the environment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587883PMC

Feeding altrenogest during late lactation improves fertility of primiparous sows nursing smaller litters.

Can J Vet Res 2019 Jul;83(3):228-230

Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand (Am-in); School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy 5371, Australia (Kirkwood).

The objective of this study was to determine whether feeding altrenogest (AT) to primiparous sows with smaller litters during the last week of lactation would improve their fertility. At day 21 of a 28-day lactation, 40 primiparous sows nursing ≤ 8 pigs were assigned equally to 2 groups, either to be fed 20 mg per day of AT for the last 7 days of lactation or to serve as untreated controls. To detect estrus, sows had daily fence-line contact with a mature boar. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588027PMC

Relationship between reproductive management practices and fertility in primiparous and multiparous dairy cows.

Can J Vet Res 2019 Jul;83(3):218-227

Department of Veterinary Forensics, Law and Economics (Fodor, Ózsvári) and Department of Biomathematics and Informatics (Lang, Abonyi-Tóth), University of Veterinary Medicine Budapest, István utca 2, H-1078 Budapest, Hungary; Research Institute for Animal Breeding, Nutrition and Meat Science, National Agricultural Research and Innovation Centre, Gesztenyés utca 1, H-2053 Herceghalom, Hungary (Gábor).

The aim of this study was to analyze the impact of reproductive management practices on fertility in primiparous and multiparous dairy cows and to identify the differences by parity. Data on reproductive performance and management of cows were gathered from 34 large commercial Holstein-Friesian dairy herds in Hungary. Individual data on 23 781 cows that calved in the studied herds in 2014 were collected from the national milk recording database and used to calculate the reproductive indices. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587879PMC
July 2019
1 Read

Effects of various dietary supplements on inflammatory processes in primary canine chondrocytes as a model of osteoarthritis.

Can J Vet Res 2019 Jul;83(3):206-217

Department of Pharmacology and Therapeutics, The Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 3J7 (AlRaddadi, Miller); Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Winter, Aukema).

The use of dietary supplements as an alternative treatment for joint-related pathologies such as osteoarthritis (OA) is increasing. However, there is little scientific evidence to support the intended use. The aim of this study was to evaluate the anti-inflammatory effects of creatine- and amino acid-based supplements in primary cultured canine chondrocytes (CnCs) as an model of OA and compare the effects to more commonly used agents, such as the non-steroidal anti-inflammatory drug (NSAID), carprofen, and the joint supplement, glucosamine (GS). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587887PMC
July 2019
3 Reads

Comparison of 3 blind brachial plexus block techniques during maintenance of anesthesia and postoperative pain scores in dogs undergoing surgical procedures of the thoracic limb.

Can J Vet Res 2019 Jul;83(3):197-205

Department of Clinical Studies (Skelding, Valverde, Aguilera, Moens, Sinclair) and Department of Biomedical Sciences (Thomason), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

The degree of analgesia provided by blind techniques for brachial plexus blocks (BPBs) has not been compared in clinical cases undergoing surgery of the thoracic limb. The objective of this study was to evaluate the anesthetic conditions and postoperative analgesia resulting from 3 different BPB local anesthetic techniques in canine patients undergoing such surgery. Twenty-four client-owned dogs received a standardized premedication/induction protocol (hydromorphone and acepromazine/propofol), maintained with isoflurane in oxygen using mechanical ventilation, in a prospective, randomized, blinded clinical trial. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587888PMC
July 2019
2 Reads

Pilot study comparing serum chemotherapy levels after intra-arterial and intravenous administration in dogs with naturally occurring urinary tract tumors.

Can J Vet Res 2019 Jul;83(3):187-196

Animal Medical Center, New York, New York 10065, USA (Kirsch, Weisse, Berent, Leibman); Hope Veterinary Specialists, Malvern, Pennsylvania 19355, USA (Clifford); University of California-Davis, School of Veterinary Medicine, Davis, California 15616, USA (Wittenburg); Memorial-Sloan Kettering Cancer Center, New York, New York 10065, USA (Solomon); Lamb Consulting, West St. Paul, Minnesota 55118, USA (Lamb).

The proposed advantages of intra-arterial chemotherapy (IAC) are based on the premises of local dose escalation to the tumor and reduced availability of systemic drugs. There is a lack of objective pharmacokinetic data to confirm the advantage of IAC in dogs with naturally occurring urogenital tumors. The objective of this study was to determine if IAC administration in urogenital tumors would result in decreased systemic drug exposure when compared to intravenous routes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587882PMC

Accuracy of external measurements of 3-dimensional (3D) printed biomodels of the canine radius used in an in-hospital setting.

Can J Vet Res 2019 Jul;83(3):181-186

Research Fellow, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Mejia); Diagnostic Imaging Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Stewart); Surgery Department, VCA Animal Specialty Group, San Diego, California, USA (Miller); Surgery Department (Savicky, Monarski) and Diagnostic Imaging Department (Keith), VCA Animal Referral and Emergency Centre of Arizona, Mesa, Arizona, USA; Department of Veterinary Administration, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA (Moore).

The objective of this study was to determine if biomodels printed on a fused deposition modeling (FDM) device from computed tomography (CT) data are accurate by comparing external measurements to the native bone, considering that the clinical usefulness of the printed biomodels in an in-hospital setting depends on their verified accuracy and consistency. Using canine cadaveric radii previously stripped of all soft tissues, 7 parameters of the actual bone and the 3-dimensional (3D) printed biomodels were measured and compared to determine how accurately the models represent the cadaveric bone. A total of 28 canine radii were collected, in which the landmarks for measurements were established. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587886PMC
July 2019
2 Reads

shedding and seropositivity and its association with in-feed flavophospholipol in nursery pigs.

Can J Vet Res 2019 Jul;83(3):177-180

Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

The objective of this study was to assess the impact of in-feed flavophospholipol on shedding and antibody response in nursery pigs. Weaned pigs were fed either a diet containing 4 ppm flavophospholipol ( = 16) or a non-medicated feed ( = 16) for 36 d. All pigs were orally challenged with a 2-mL dose of 10 colony-forming units (CFUs)/mL of Typhimurium on Days 7 and 8 of the trial. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587880PMC

Molecular variability of isolates from intramammary infections in Canadian dairy farms from the Maritime region.

Can J Vet Res 2019 Jul;83(3):168-176

Department of Health Management (Reyes, McClure, Sánchez) and Department of Pathology and Microbiology (Rodriguez-Lecompte), Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island C1A 4P3; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, England (Blanchard).

The primary objective of this study was to explore the variability of isolates by extracting multilocus sequence typing (MLST) data from whole-genome sequencing. The secondary objective was to determine the distribution of the phenotypic antimicrobial resistance (AMR) and the associated AMR genes as well as the virulence gene profiles among sequence types (STs). Sixty-two isolates were recovered from 16 herds in 3 Canadian Maritime Provinces: New Brunswick (14. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587884PMC

Molecular characterization of subspecies C-type and S-type isolated from sheep and goats by using a combination of MIRU-VNTR loci.

Can J Vet Res 2019 Jul;83(3):160-167

Canadian Food Inspection Agency, 3400 Casavant, St-Hyacinthe (Sohal, Robinson, Lachapelle, L'Homme); Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, St-Hyacinthe (Arsenault, Hélie, Buczinski, Fecteau, L'Homme); Ministère de l'Agriculture, des pêcheries et de l'alimentation du Quebec, 200 chemin Ste-Foy (Leboeuf); Laboratoire de santé animale du Quebec, Ministère de l'Agriculture, des pêcheries et de l'alimentation du Quebec, 3220 Sicotte, St-Hyacinthe, Quebec (Labrecque).

subspecies (Map) is the etiological agent of paratuberculosis of domestic and wild ruminants. Map strains are segregated into 2 main groups or strain types referred to as sheep (S) type and cattle (C) type. Few small ruminant Map strains have been genetically characterized to date. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587881PMC
July 2019
1 Read

Effect of full open-palm hand shielding on worker radiation dose during manual restraint for small animal radiography.

Can J Vet Res 2019 Apr;83(2):154-158

Departments of Small Animal Clinical Sciences (Mayer) and Large Animal Clinical Sciences (Waldner), Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4; Department of Medicine, 107 Wiggins Road, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5 (Koehncke, Gallagher); Medical Physics, British Columbia Cancer, 1215 Lethbridge Street, Prince George, British Columbia V2M 7E9 (Sidhu).

Open-palm hand shields are used by veterinary workers during manual restraint for small animal radiography. The objective of this study was to measure the reduction in scatter and primary beam radiation dose to the hand provided by a full glove and an open-palm shield, using a cadaver dog to simulate restraint by 2 workers of an awake, cooperative patient undergoing thoracic and abdominal radiography. Dose was measured for 30 exposures for each condition, for a total of 795 exposures. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450160PMC

Use of a colorimetric assay to evaluate the proliferation of canine mammary tumor cells exposed to propofol.

Can J Vet Res 2019 Apr;83(2):149-153

Anaesthesiology and Perioperative Intensive-Care Medicine, Veterinary University Vienna, Veterinaerplatz 1, 1210 Vienna, Austria (Argano, Rodlsberger, Menzies); Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland (Argano); Department of Veterinary Sciences-Surgery Unit, Veterinary Faculty of the University of Turin, Italy (De Maria, Buracco).

Drugs applied on human cancer cells can influence the rate of cell proliferation. The present study investigates the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide (MTT) colorimetric assay to evaluate canine tumor cell proliferation after exposure to the injectable anesthetic, propofol. Primary (CIPp) and metastatic (CIPm) canine tubular adenocarcinoma cell lines were incubated with cell culture medium (control) or propofol (1, 5, and 10 μg/mL). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450161PMC
April 2019
1 Read

A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed.

Can J Vet Res 2019 Apr;83(2):142-148

CullenWebb Animal Eye Specialists, Riverview, New-Brunswick E1B 4X2 (Webb); Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 1N4 (Webb); ProjectDog, Davis, California 95616, USA (Ruhe); Van Andel Research Institute, Grand Rapids, Michigan 49503, USA (Ruhe, Neff); Translational Genomics Research Institute, Phoenix, Arizona 85004, USA (Neff).

Bilateral deafness with concurrent vestibular dysfunction was first reported in the Doberman pinscher in 1980. Here, we identify a coding mutation in the MYO7A gene that is perfectly associated with the disorder. The lack of visual deficits in affected dogs suggests that, like rodents but unlike humans, MYO7A is not required for retinal function. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450158PMC
April 2019
2 Reads

Osteoarthritic pain model influences functional outcomes and spinal neuropeptidomics: A pilot study in female rats.

Can J Vet Res 2019 Apr;83(2):133-141

GREPAQ (Research Group in Animal Pharmacology of Quebec), Département de biomédecine vétérinaire (Gervais, Otis, Guillot, Beaudry, Troncy) and Département de sciences cliniques (Lussier), Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, Québec; Osteoarthritis Research Unit, Université de Montréal Hospital Research Centre (CRCHUM), Montreal, Quebec (Lussier, Martel-Pelletier, Pelletier, Troncy).

Osteoarthritis, the leading cause of chronic joint pain, is studied through different animal models, but none of them is ideal in terms of reliability and translational value. In this pilot study of female rats, 3 surgical models of osteoarthritic pain, destabilization of the medial meniscus (DMM), cranial cruciate ligament transection (CCLT), and the combination of both surgical models (COMBO) and 1 chemical model [intra-articular injection of monosodium iodoacetate (MIA)] were compared for their impact on functional pain outcomes [static weight-bearing (SWB) and punctate tactile paw withdrawal threshold (PWT)] and spinal neuropeptides [substance P (SP), calcitonin gene-related peptide (CGRP), bradykinin (BK), and somatostatin (SST)]. Six rats were assigned to each model group and a sham group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450163PMC
April 2019
3 Reads