120,485 results match your criteria Canadian Journal Of Plant Pathology[Journal]


Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt/β-catenin signaling pathway.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology & Toxicology, Cairo University, Cairo, Egypt. Electronic address:

Exposure to repetitive brain trauma has gained attention for its similarity to sport-related trauma. The traumatic brain injury (TBI) is strongly associated with neurodegenerative pathology that affects cognition, memory and behavior. The current study developed a novel mild repetitive traumatic brain injury (mRTBI) model to highlight some of the possible molecular pathological mechanisms compared to those of single trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193018
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http://dx.doi.org/10.1016/j.brainres.2019.04.003DOI Listing
April 2019
1 Read

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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http://dx.doi.org/10.1113/JP277775DOI Listing

Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
1 Read

Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e22-e38. Epub 2019 Jan 22.

College of Pharmacy, University of Manitoba.

Purpose:  1) To evaluate trends for benzodiazepines (BZD) and Z-Drugs over 15-years in a general Canadian adult population measured by: a) consumption b) pharmacologic exposure c) dose intensity and d) prevalence of use. 2) To demonstrate the utility of Diazepam Milligram Equivalence (DME) based measurements when used in conjunction with traditional standard measurements of drug utilization such as the Defined Daily Dose (DDD) system.

Methods: Administrative data covering all prescriptions from April 2001-March 2016 for BZD and Z-Drugs for patients ≥18 years was used. Read More

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http://www.jptcp.com/index.php/jptcp/article/view/52
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http://dx.doi.org/10.22374/1710-6222.26.1.3DOI Listing
January 2019
1 Read

Response to Letter to the Editor.

Authors:
Nigel S B Rawson

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e20-e21. Epub 2019 Jan 22.

Eastlake Research Group, Oakville, Ontario; Canadian Health Policy Institute, Toronto; Ontario; Fraser Institute, Vancouver, British Columbi.

Author's response to comments from Dr Lexchin's Letter to the Editor regarding our article. Read More

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http://jptcp.com/index.php/jptcp/article/view/394
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http://dx.doi.org/10.22374/1710-6222.26.1.2DOI Listing
January 2019
1 Read

What is your diagnosis? A shoulder mass in a great horned owl.

Vet Clin Pathol 2019 Apr 19. Epub 2019 Apr 19.

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vcp.12738
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http://dx.doi.org/10.1111/vcp.12738DOI Listing
April 2019
1 Read

Reducing ethnic disparity in access to high-quality HLA-matched cord blood units for transplantation: analysis of the Canadian Blood Services' Cord Blood Bank inventory.

Transfusion 2019 Apr 19. Epub 2019 Apr 19.

Canadian Blood Services' Cord Blood Bank, Ottawa, Ontario.

Background: Launched in 2013, Canadian Blood Services' Cord Blood Bank (CBS' CBB) has built a high-quality, ethnically diverse cord blood repository that aims to reduce ethnic disparity in accessing suitable units for transplantation.

Methods And Results: As of December 2016, 2000 units have been banked. The self-reported maternal ethnicity was 58% non-Caucasian. Read More

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http://dx.doi.org/10.1111/trf.15313DOI Listing

Training Pediatric Residents in Literacy Promotion: Residency Directors' Perspectives.

Teach Learn Med 2019 Apr 19:1-8. Epub 2019 Apr 19.

a The Department of Pediatrics , Rutgers Robert Wood Johnson Medical School , New Brunswick , New Jersey , USA.

Phenomenon: The American Academy of Pediatrics and Canadian Pediatric Society recommend that pediatricians incorporate literacy promotion during well child care, but literacy promotion education during pediatric training remains understudied. We sought to understand how literacy promotion training is currently implemented in pediatric residency programs from the perspective of program directors. Approach: We conducted semistructured interviews with all 9 residency program directors in 1 state. Read More

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http://dx.doi.org/10.1080/10401334.2019.1598866DOI Listing
April 2019
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Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Cancer Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.1996
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http://dx.doi.org/10.1002/cam4.1996DOI Listing
April 2019
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Gene expression analysis of follicular cells revealed inflammation as a potential IVF failure cause.

J Assist Reprod Genet 2019 Apr 18. Epub 2019 Apr 18.

Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), Université Laval, 2440 Boulevard Hochelaga, Québec, QC, G1V 0A6, Canada.

Purpose: Hormonal stimulation prior to IVF influences the ovarian environment and therefore impacts oocytes and subsequent embryo quality. Not every patient has the same response to the same treatment and many fail for unknown reasons. Knowing why a cycle has failed and how the follicles were affected would allow clinicians to adapt the treatment accordingly and improve success rate. Read More

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http://dx.doi.org/10.1007/s10815-019-01447-4DOI Listing

Emotion And Symptom-focused Engagement (EASE): a randomized phase II trial of an integrated psychological and palliative care intervention for patients with acute leukemia.

Support Care Cancer 2019 Apr 17. Epub 2019 Apr 17.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, 16th Floor, Toronto, Ontario, M5G 2M9, Canada.

Purpose: We designed a novel, manualized intervention called Emotion And Symptom-focused Engagement (EASE) for acute leukemia (AL) and report here on a phase II randomized controlled trial (RCT) to assess its feasibility and preliminary efficacy.

Methods: Patients were recruited within 1 month of hospital admission and randomized to EASE plus usual care (UC) or UC alone. EASE includes (1) EASE-psy, a tailored psychotherapy delivered over 8 weeks, and (2) EASE-phys, weekly physical symptom screening over 8 weeks to trigger early palliative care. Read More

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http://dx.doi.org/10.1007/s00520-019-04723-2DOI Listing

Cross-Cultural Validation of the English Chronic Pain Myth Scale in Emergency Nurses.

Pain Res Manag 2019 14;2019:1926987. Epub 2019 Mar 14.

College of Nursing, Florida State University, Tallahassee, FL, USA.

Background: Utilization of the emergency department (ED) by patients seeking relief from chronic pain (CP) has increased. These patients often face stigmatization, and the ED is no exception. The French-Canadian Chronic Pain Myth Scale (CPMS) was developed to evaluate common societal misconceptions about CP including among healthcare providers. Read More

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http://dx.doi.org/10.1155/2019/1926987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437722PMC

Early-onset emphysema in a large French-Canadian family: a genetic investigation.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec, Canada.

Background: Inherited mutations in SERPINA1 coding for the alpha-1 antitrypsin (A1AT) protein is the only well established cause of hereditary emphysema. We aimed to identify the genetic ecause of early-onset emphysema in a five-generation French-Canadian family free of A1AT deficiency.

Methods: Between Dec 1, 2014, and April 1, 2017, we investigated 63 individuals from a single pedigree, including 55 with DNA available. Read More

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http://dx.doi.org/10.1016/S2213-2600(19)30056-6DOI Listing

Characterisation of the volatile flavour compounds in low and high tannin faba beans (Vicia faba var. minor) grown in Alberta, Canada.

Food Res Int 2019 Jun 26;120:285-294. Epub 2019 Feb 26.

Lipid Chemistry Group, Department of Agricultural, Food and Nutrition Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The volatile flavour profiles of Canadian-grown faba beans (Vicia faba var. minor) were evaluated by headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography-mass spectrometry (GC-MS). Two low- and high-tannin varieties were chosen, each in the form of dehulled and whole seed flours (DLT, DHT, WLT, and WHT, respectively). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969193013
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http://dx.doi.org/10.1016/j.foodres.2019.02.044DOI Listing
June 2019
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Patient-level resource use for injury admissions in Canada: A multicentre retrospective cohort study.

Injury 2019 Mar 28. Epub 2019 Mar 28.

Institut national d'excellence en santé et en services sociaux (INESSS), Québec, QC, Canada; Department of Surgery, Université Laval, Québec, QC, Canada.

Background: Variations in adjusted costs have been observed among trauma centres in the United States but patient outcomes were not better in centres with higher costs. Attempts to improve injury care efficiency are hampered by insufficient patient-level information on resource use and on the drivers of resource use intensity.

Objectives: To estimate patient-level resource use for injury admissions, identify determinants of resource use intensity, and evaluate inter-hospital variations in resource use. Read More

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http://dx.doi.org/10.1016/j.injury.2019.03.038DOI Listing

Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV (PURE): an international, community-based cohort study.

Lancet Glob Health 2019 May;7(5):e613-e623

Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Background: The associations between the extent of forced expiratory volume in 1 s (FEV) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown.

Methods: In this international, community-based cohort study, we prospectively enrolled adults aged 35-70 years who had no intention of moving residences for 4 years from rural and urban communities across 17 countries. A portable spirometer was used to assess FEV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193007
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http://dx.doi.org/10.1016/S2214-109X(19)30070-1DOI Listing
May 2019
1 Read

Effect of stem cell transplantation on patients with ischemic heart failure: a systematic review and meta-analysis of randomized controlled trials.

Stem Cell Res Ther 2019 Apr 18;10(1):125. Epub 2019 Apr 18.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety of SCT in IHF patients. Randomized controlled trials (RCTs) involving stem cell transplantation for the treatment of IHF were identified by searching the PubMed, EMBASE, SpringerLink, Web of Science, and Cochrane Systematic Review databases as well as from reviews and the reference lists of relevant articles. Read More

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http://dx.doi.org/10.1186/s13287-019-1214-0DOI Listing

The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Institute of Cardiovascular Sciences and the Canadian Centre for Agri-food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H2A6, Canada.

Food quality and nutritional habits strongly influence human health status. Extensive research has been conducted to confirm that foods rich in biologically active nutrients have a positive impact on the onset and development of different pathological processes, including cardiovascular diseases. However, the underlying mechanisms by which dietary compounds regulate cardiovascular function have not yet been fully clarified. Read More

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https://www.mdpi.com/1420-3049/24/8/1509
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http://dx.doi.org/10.3390/molecules24081509DOI Listing
April 2019
1 Read

Influence of Perceived Racial Discrimination on the Health of Immigrant Children in Canada.

J Int Migr Integr 2018 24;19(3):527-540. Epub 2018 Feb 24.

4Sociology, Kwantlen Polytechnic University, Surrey, British Columbia Canada.

Racial discrimination and racism are recognized as determinants of health for adults. Less is understood regarding the influence of discrimination targeted towards parents, the family, or the cultural and children's health. Data from the New Canadian Children and Youth Study (NCCYS) are used in this paper. Read More

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http://dx.doi.org/10.1007/s12134-018-0539-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434967PMC
February 2018

: Shaping future healthcare teams through simulation-enhanced interprofessional education.

Can J Respir Ther 2017 1;53(4):81-87. Epub 2017 Nov 1.

Department of Nursing and Health Science, University of New Brunswick Saint John, Saint John, NB, Canada.

Background: Simulation-enhanced interprofessional education (sim-IPE) is a growing component of undergraduate health curricula, preparing learners for the practice environment and, in doing so, redefining practice culture. The Canadian Interprofessional Health Collaborative (CIHC) has established a national competency framework of integrative competency domains focused on fostering core skills, attitudes, and values in an effort to evolve interprofessional collaboration (IPC). This framework serves as the foundational underpinning for IPE within all health professions. Read More

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November 2017
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Towards an enhanced conceptualization of fidelity for instructional design in simulation-based respiratory therapy education.

Can J Respir Ther 2017 1;53(4):69-74. Epub 2017 Nov 1.

College of Education, University of Saskatchewan, Saskatoon, SK, Canada.

Despite the apparent centrality of fidelity to clinical simulation instructional design and practice in respiratory therapy education, it remains one of most contested constructs in the simulation literature. Fidelity has been described as educationally under-theorized resulting in an emphasis often being placed on technological sophistication rather than theory-informed design, particularly in respiratory therapy. This article critically examines various conceptualizations of fidelity in the field of clinical simulation in an effort to inform its instructional design practices. Read More

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November 2017

The practice of simulation-based assessment in respiratory therapy education.

Can J Respir Ther 2017 1;53(1):13-16. Epub 2017 Feb 1.

College of Education, University of Saskatchewan, Saskatoon, SK.

Clinical simulation has gained prominence as an educational approach in many Canadian respiratory therapy programs and is strongly associated with improved learning, clinical and nonclinical skill, future performance, and patient outcomes. Traditionally, the primary assessment approach employed in clinical simulation has been formative debriefing for learning. Contextual factors, such as limited opportunities for learning in clinical practice and technologically oriented perspectives on learning in clinical simulation, are converging to prompt a move from using formative debriefing sessions that support learning in simulation to employing high-stakes testing intended to measure entry-to-practice competencies. Read More

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February 2017
1 Read

Arrowhead () as a bioindicator of nitrogen and phosphorus for prairie streams and wetlands.

Wetl Ecol Manag 2018 27;26(3):331-343. Epub 2017 Sep 27.

1Biology Department and Canadian Rivers Institute, University of New Brunswick, PO Box 4400, Fredericton, NB E3B 5A3 Canada.

The emergent aquatic plant, is an easily-identified and commonly-found species in the Great Plains region of North America and has the potential to be a bioindicator of nitrogen (N) and phosphorus (P) because of its previously-identified leaf plasticity in response to nutrient conditions. To identify associations between leaf morphology and soil and water nutrients, we conducted: (1) a 10-week controlled experiment in which plants were grown in nutrient-enriched sediment, nutrient-enriched water, or unamended control trials, and (2) a field study where emergent leaves were collected from 15 streams of varying nutrient concentrations. Plants grown in experimentally enriched sediment were more productive than those grown in enriched water or control conditions: they produced more emergent leaves and tubers, had a larger final biomass and height, and developed emergent leaves that showed a consistent increase in size and unique change in shape over time. Read More

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http://dx.doi.org/10.1007/s11273-017-9576-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438639PMC
September 2017

Steady-state visual evoked potentials reveal enhanced neural responses to illusory surfaces during a concurrent visual attention task.

Cortex 2019 Mar 26;117:217-227. Epub 2019 Mar 26.

The University of Queensland, Queensland Brain Institute, St Lucia, QLD, Australia; The University of Queensland, School of Psychology, St Lucia, QLD, Australia; Canadian Institute for Advanced Research (CIFAR), Toronto, Canada.

Under natural viewing conditions, visual stimuli are often obscured by occluding surfaces. To aid object recognition, the visual system actively reconstructs the missing information, as exemplified in the classic Kanizsa illusion, a phenomenon termed "modal completion". Single-cell recordings in monkeys have shown that neurons in early visual cortex respond to illusory contours, but it has proven difficult to measure the neural correlates of modal completion in humans. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.03.014DOI Listing

Porous iron material for TcO- and ReO- sequestration from groundwater under ambient oxic conditions.

J Hazard Mater 2019 Apr 9;374:177-185. Epub 2019 Apr 9.

Hӧganäs Environmental Solutions LLC, Cary, NC, 27513, USA.

Technetium-99 (Tc) is a major contaminant at nuclear power plants and several US Department of Energy sites. Its most common aqueous species, pertechnetate (TcO), is very mobile in the environment, and currently there are no effective technologies for its sequestration. In this work, a porous iron (pFe) material was investigated for TcO and perrhenate (ReO) sequestration from artificial groundwater. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043894193045
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http://dx.doi.org/10.1016/j.jhazmat.2019.04.030DOI Listing
April 2019
2 Reads

Barriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews.

PLoS One 2019 18;14(4):e0215384. Epub 2019 Apr 18.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, Toronto, Ontario, Canada.

Background: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study was to investigate barriers and facilitators of communication between persons with Parkinson's disease, carepartners, and physicians, specifically in the setting of off periods, with the goal of identifying ways to improve patient-carepartner-physician communication.

Method: We interviewed persons with Parkinson's, carepartners, and physicians (specialists and non-specialists) using a semi-structured questionnaire to identify and describe experiences, barriers, and facilitators relating to communication about off periods in Parkinson's disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215384PLOS
April 2019
1 Read

Perceptions on Use of the Subjective Global Assessment Before and After It Became Part of Regular Practice.

Nutr Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Nutrition & Aging Lab, Schlegel-UW Research Institute for Aging, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.

Background: Subjective global assessment (SGA) is a standardized diagnostic tool for malnutrition and identifies those who would benefit from nutrition treatment. SGA has been validated in several patient populations; however, implementation in clinical practice is inconsistent. The objective of this study was to understand and contrast the perceptions on use of SGA before and after it became a regular practice for hospital dietitians. Read More

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http://dx.doi.org/10.1002/ncp.10270DOI Listing

Quantile regression and empirical likelihood for the analysis longitudinal data with monotone missing responses due to dropout, with applications to quality of life measurements from clinical trials.

Stat Med 2019 Apr 17. Epub 2019 Apr 17.

Canadian Cancer Trials Group, Queen's University, Kingston, Canada.

The analysis of quality of life (QoL) data can be challenging due to the skewness of responses and the presence of missing data. In this paper, we propose a new weighted quantile regression method for estimating the conditional quantiles of QoL data with responses missing at random. The proposed method makes use of the correlation information within the same subject from an auxiliary mean regression model to enhance the estimation efficiency and takes into account of missing data mechanism. Read More

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http://dx.doi.org/10.1002/sim.8152DOI Listing
April 2019
1 Read

Extraction of nucleic acids from blood: unveiling the potential of active pneumatic pumping in centrifugal microfluidics for integration and automation of sample preparation processes.

Lab Chip 2019 Apr 18. Epub 2019 Apr 18.

National Research Council of Canada, Life Sciences Division, 75 de Mortagne Boulevard, Boucherville, QC J4B 6Y4, Canada. and Department of Biomedical Engineering, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada.

This paper describes the development of an on-chip nucleic acid (NA) extraction assay from whole blood using a centrifugal microfluidic platform that allows for pneumatic actuation of liquids during rotation. The combination of pneumatic and centrifugal forces makes it possible to perform fluidic operations without the need for integrating active control elements on the microfluidic cartridge. The cartridge is fabricated from thermoplastic polymers (e. Read More

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http://dx.doi.org/10.1039/c9lc00276fDOI Listing

Care of acute conditions and chronic diseases in Canada and the United States: Rapid systematic review and meta-analysis.

J Public Health Res 2019 Mar 11;8(1):1479. Epub 2019 Mar 11.

School of Social Work.

This study tested the hypothesis that socioeconomically vulnerable Canadians with diverse acute conditions or chronic diseases have health care access and survival advantages over their counterparts in the USA. A rapid systematic review retrieved 25 studies (34 independent cohorts) published between 2003 and 2018. They were synthesized with a streamlined meta-analysis. Read More

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http://dx.doi.org/10.4081/jphr.2019.1479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444377PMC
March 2019
1 Read

Improving lung cancer diagnosis: the evolving role of patients and care providers.

J Thorac Dis 2019 Mar;11(Suppl 3):S422-S424

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.21037/jtd.2018.11.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424746PMC

Angina and left ventricular dysfunction: can we 'reduce' it?

Eur Heart J Suppl 2019 Apr 10;21(Suppl C):C28-C31. Epub 2019 Apr 10.

Department of Medical Sciences Ferrara University, Ferrara, Italy.

Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis with subsequent transcatheter valve-in-valve implantation for bioprosthesis degeneration and single coronary artery bypass graft with left internal mammary artery on left anterior descending (LAD). After transcatheter aortic valve implantation, she started to complain angina [Canadian Cardiovascular Society (CCS) Class III], effectively treated with bisoprolol uptitration and ivabradine 5 b. Read More

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http://dx.doi.org/10.1093/eurheartj/suz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456877PMC
April 2019
2 Reads

Angina and chronic obstructive pulmonary disease: facing the perfect storm.

Eur Heart J Suppl 2019 Apr 10;21(Suppl C):C17-C20. Epub 2019 Apr 10.

Cardiovascular Centre of Ferrara University, Ferrara, Italy.

The association of chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) is challenging both in terms of prognosis and of pharmacological treatment. An 83-year-old Caucasian male patient has chronic kidney disease, COPD, previous myocardial infarction, coronary artery bypass graft with left internal mammary artery (LIMA) on left anterior descending (LAD), saphenous vein graft (SVG) on obtuse marginal (OM)1 and on right coronary artery, and percutaneous coronary intervention (PCI) on LAD (occlusion of LIMA) and on SVG for OM1 (SVG critical stenosis). Recently, the patient complained worsening angina [Canadian Cardiovascular Society (CCS) III] and had residual ischaemia in the anterior wall after an unsuccessful attempt of PCI was performed on LAD for in-stent occlusion due to restenosis. Read More

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http://dx.doi.org/10.1093/eurheartj/suz042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456878PMC

CPHLN recommendations for the laboratory detection of Shiga toxin-producing (O157 and non-O157).

Can Commun Dis Rep 2018 Nov 1;44(11):304-307. Epub 2018 Nov 1.

National Microbiology Laboratory, MB & ON.

Shiga toxin-producing (STEC) are important enteric pathogens responsible for sporadic cases and outbreaks of gastroenteritis. O157:H7/NM (STEC O157) are the most commonly known STEC serotypes but it is now increasingly apparent that non-O157 STEC serotypes have been underreported in the past because they were not part of routine screening in many front-line laboratories. The Canadian Public Health Laboratory Network (CPHLN) has identified the need for improved detection and surveillance of non-O157 STEC and has developed the following recommendations to assist in the decision-making process for clinical and reference microbiology laboratories. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449107PMC
November 2018
2 Reads

Tuberculosis drug resistance in Canada: 2017.

Can Commun Dis Rep 2018 Nov 1;44(11):290-296. Epub 2018 Nov 1.

Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Background: Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years.

Objective: To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well as geographic location, demographic data and origin and to compare current data to those of the previous 10 years. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449088PMC
November 2018
1 Read

The National Advisory Committee on Infection Prevention and Control (NAC-IPC).

Can Commun Dis Rep 2018 Nov 1;44(11):283-289. Epub 2018 Nov 1.

University of Manitoba, Winnipeg, MB.

This paper describes the work of the National Advisory Committee on Infection Prevention and Control (NAC-IPC), previously Infection Prevention and Control Expert Working Group, a longstanding external advisory body that provides subject matter expertise and advice to the Public Health Agency of Canada (PHAC) on the prevention and control of infectious diseases in Canadian health care settings. Originally established by Health Canada as the Infection Control Guidelines Steering Committee in 1992, this advisory board has been providing expert advice on infection prevention and control (IPC) guideline development for over 25 years. The NAC-IPC provides advice to inform the development of comprehensive or concise guidelines, quick reference guides and interim guidelines (usually for emerging pathogens), working closely with PHAC's national Healthcare-Associated Infections (HAIs) surveillance programs for Canadian health care facilities. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449104PMC
November 2018
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Looking ahead: The state and future of the .

Authors:
Sorge Justin

Can J Respir Ther 2018 1;54(1). Epub 2018 May 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422013PMC

The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation.

Paediatr Child Health 2019 May 6;24(2):e111-e115. Epub 2018 Aug 6.

Department of Pathology and Laboratory Medicine, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.

Background: The hepatic carnitine palmitoyltransferase I () p.P479L variant is common in Aboriginal populations across coastal British Columbia, Alaska, the Canadian North, and Greenland. While the high frequency of this variant suggests positive selection, other studies have shown an association with sudden unexpected death in infancy and infection. Read More

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https://academic.oup.com/pch/article/24/2/e111/5067175
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http://dx.doi.org/10.1093/pch/pxy106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462176PMC
May 2019
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Nasal CPAP on paediatric air transport in the Canadian Arctic: A case series.

Paediatr Child Health 2019 May 13;24(2):e94-e97. Epub 2018 Jun 13.

Department of Anaesthesia, Qikiqtani General Hospital, Iqaluit, Nunavut.

Aims: Paediatric transport in remote regions of Canada represents a huge challenge given the acuity of the patients, immense distances, weather and lack of road infrastructure. Transport of patients in the Baffin region of Nunavut is completed entirely by air transport. Two very common paediatric transports are in regards to lower respiratory tract infections and premature deliveries in small rural communities north of Iqaluit. Read More

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http://dx.doi.org/10.1093/pch/pxy088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462123PMC

Population-based study of early-onset neonatal sepsis in Canada.

Paediatr Child Health 2019 May 24;24(2):e66-e73. Epub 2018 Apr 24.

Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario.

Objective: To determine the incidence, types of organisms and resistance patterns involved in early-onset neonatal sepsis in Canada.

Study Design: Early-onset neonatal sepsis cases were identified through the Canadian Paediatric Surveillance Program. Neonates were excluded if they were asymptomatic or if intracranial procedures preceded a positive cerebrospinal fluid culture. Read More

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https://academic.oup.com/pch/article/24/2/e66/4983126
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http://dx.doi.org/10.1093/pch/pxy018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462127PMC
May 2019
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Vaccine-preventable diseases: Uncommon disease primer for the front-line provider.

Paediatr Child Health 2019 May 13;24(2):130-131. Epub 2019 Apr 13.

Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.

This practice point provides quick information for front-line health care providers on vaccine-preventable diseases which, given the success of immunization programs in Canada, are now uncommon or rarely seen. These infections can still occur in children and youth from Canada and elsewhere, and their clinical identification has important public health implications. Knowledge of signs and symptoms, immunizing travellers and newcomers to Canada, awareness of outbreaks in-community and elsewhere, and early consultation with an expert in infectious diseases and public health authorities in suspected cases, are key preventive care measures. Read More

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https://academic.oup.com/pch/article/24/2/130/5453786
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http://dx.doi.org/10.1093/pch/pxz044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462137PMC
May 2019
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Invasive group A streptococcal disease: Management and chemoprophylaxis.

Paediatr Child Health 2019 May 13;24(2):128-129. Epub 2019 Apr 13.

Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.

Reporting of severe invasive group A streptococcal disease (IGAS) has increased in Canada over the past decade, highlighting the importance of optimal chemoprophylaxis and management strategies. Canadian guidelines have had variable uptake across Canada. This practice point updates relevant aspects of these guidelines, with a focus on chemoprophylaxis of contacts of IGAS cases and clinical management of IGAS. Read More

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https://academic.oup.com/pch/article/24/2/128/5453785
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http://dx.doi.org/10.1093/pch/pxz039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462117PMC
May 2019
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Acute encephalopathy associated with influenza infection: Case report and review of the literature.

Paediatr Child Health 2019 May 28;24(2):122-124. Epub 2018 Jun 28.

Departments of Pediatrics and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia.

Influenza has been associated with neurological complications. We describe the case of a toddler who presented with symptoms and signs of acute encephalopathy and hydrocephalus. Neuroimaging demonstrated cerebral edema and multifocal diffusion restriction in the thalamus and splenium of the corpus callosum. Read More

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http://dx.doi.org/10.1093/pch/pxy085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462119PMC