127,538 results match your criteria Canadian Journal Of Plant Pathology[Journal]


Evaluation of the SNAP® 4Dx® plus test for the detection of Dirofilaria immitis antigen and characterization of exposure to tick-borne pathogens in wild canids in southern Ontario.

Vet Parasitol 2020 Jun 25;283:109176. Epub 2020 Jun 25.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Population-level surveys for Dirofilaria immitis in wild canids typically rely on identification of the parasite at necropsy. More recently, some studies have employed the use of the SNAP® 4Dx® Plus test. However, since the assay was designed for use with domestic dogs it needs to be validated for use with wild canids for accurate interpretation of results. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109176DOI Listing

Rapid review methods more challenging during COVID-19: Commentary with a focus on 8 knowledge synthesis steps.

J Clin Epidemiol 2020 Jun 29. Epub 2020 Jun 29.

Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, 209 Victoria Street, East Building, Toronto, ON, M5B 1T8, Canada; Department of Geriatric Medicine, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada.

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.029DOI Listing

Neural Oscillations and Brain Stimulation in Alzheimer's Disease.

Prog Neurobiol 2020 Jun 29:101878. Epub 2020 Jun 29.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. Electronic address:

Aging is associated with alterations in cognitive processing and brain neurophysiology. Whereas the primary symptom of amnestic mild cognitive impairment (aMCI) is memory problems greater than normal for age and education, patients with Alzheimer's disease (AD) show impairments in other cognitive domains in addition to memory dysfunction. Resting-state electroencephalography (rsEEG) studies in physiological aging indicate a global increase in low-frequency oscillations' power and the reduction and slowing of alpha activity. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2020.101878DOI Listing

Cortical Bone Porosity in Rabbit Models of Osteoporosis.

J Bone Miner Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on trabecular microarchitecture or bone density; some such as ovariectomy (OVX) have uncertain efficacy and cortical porosity has not been extensively reported. Read More

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http://dx.doi.org/10.1002/jbmr.4124DOI Listing

Using machine learning to quantify structural MRI neurodegeneration patterns of Alzheimer's disease into dementia score: Independent validation on 8,834 images from ADNI, AIBL, OASIS, and MIRIAD databases.

Hum Brain Mapp 2020 Jul 2:e25115. Epub 2020 Jul 2.

School of Engineering Science, Simon Fraser University, Barnaby, British Columbia, Canada.

Biomarkers for dementia of Alzheimer's type (DAT) are sought to facilitate accurate prediction of the disease onset, ideally predating the onset of cognitive deterioration. T1-weighted magnetic resonance imaging (MRI) is a commonly used neuroimaging modality for measuring brain structure in vivo, potentially providing information enabling the design of biomarkers for DAT. We propose a novel biomarker using structural MRI volume-based features to compute a similarity score for the individual's structural patterns relative to those observed in the DAT group. Read More

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http://dx.doi.org/10.1002/hbm.25115DOI Listing

Translating Outcome Frameworks to Assessment Programs: Implications for Validity.

Med Educ 2020 Jul 2. Epub 2020 Jul 2.

Centre for Simulation Based Learning and Department of Medicine, McMaster University, Hamilton, On, Canada.

Introduction: Competency based medical education (CBME) requires that educators structure assessment of clinical competence using outcome frameworks. While these frameworks may serve some outcomes well (e.g. Read More

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http://dx.doi.org/10.1111/medu.14287DOI Listing

Association of Atrial Fibrillation Episode Duration With Arrhythmia Recurrence Following Ablation: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open 2020 Jul 1;3(7):e208748. Epub 2020 Jul 1.

Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada.

Importance: Contemporary guidelines recommend that atrial fibrillation (AF) be classified based on episode duration, with these categories forming the basis of therapeutic recommendations. While pragmatic, these classifications are not based on pathophysiologic processes and may not reflect clinical outcomes.

Objective: To evaluate the association of baseline AF episode duration with post-AF ablation arrhythmia outcomes. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.8748DOI Listing

Impact of Time-To-Surgery and Surgical Delay on Oncologic Outcomes for Renal Cell Carcinoma.

J Urol 2020 Jul 2:101097JU0000000000001230. Epub 2020 Jul 2.

Section of Urology, University of Manitoba, Winnipeg, Manitoba, Canada.

Purpose: The time between radiographic identification of a renal tumor and surgery can be concerning for patients and clinicians due to fears of tumor progression while awaiting treatment. This study aimed to evaluate the association between surgical wait time and oncologic outcomes for patients with renal cell carcinoma (RCC).

Materials And Methods: The Canadian Kidney Cancer information system (CKCis) is a multi-institutional prospective cohort initiated in January 2011. Read More

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http://dx.doi.org/10.1097/JU.0000000000001230DOI Listing

Active surveillance of acute paediatric hospitalisations demonstrates the impact of vaccination programmes and informs vaccine policy in Canada and Australia.

Euro Surveill 2020 Jun;25(25)

The IMPACT and PAEDS investigators are acknowledged at the end of this article.

Sentinel surveillance of acute hospitalisations in response to infectious disease emergencies such as the 2009 influenza A(H1N1)pdm09 pandemic is well described, but recognition of its potential to supplement routine public health surveillance and provide scalability for emergency responses has been limited. We summarise the achievements of two national paediatric hospital surveillance networks relevant to vaccine programmes and emerging infectious diseases in Canada (Canadian Immunization Monitoring Program Active; IMPACT from 1991) and Australia (Paediatric Active Enhanced Disease Surveillance; PAEDS from 2007) and discuss opportunities and challenges in applying their model to other contexts. Both networks were established to enhance capacity to measure vaccine preventable disease burden, vaccine programme impact, and safety, with their scope occasionally being increased with emerging infectious diseases' surveillance. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.1900562DOI Listing

How to Work Collaboratively Within the Health System: Workshop Summary and Facilitator Reflection.

Int J Health Policy Manag 2020 Jun 1;9(6):233-239. Epub 2020 Jun 1.

Health Services Integration, Winnipeg Regional Health Authority, Winnipeg, MB, Canada.

Effectiveness in health services research requires development of specific knowledge and skills for working in partnership with health system decision-makers. In an initial effort to frame capacity-building activities for researchers, we designed a workshop on working collaboratively within the health system. The workshop, based on recent research exploring health system experience and perspectives on research collaborations, was trialed at the annual Canadian Health Services and Policy Research (CAHSPR) conference in May 2019. Read More

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http://dx.doi.org/10.15171/ijhpm.2019.131DOI Listing

Temperature-Dependent Chemical and Physical Microstructure of Li Metal Anodes Revealed through Synchrotron-Based Imaging Techniques.

Adv Mater 2020 Jul 1:e2002550. Epub 2020 Jul 1.

Department of Mechanical and Materials Engineering, University of Western Ontario, London, ON, N6A 5B9, Canada.

The Li metal anode has been long sought-after for application in Li metal batteries due to its high specific capacity (3860 mAh g ) and low electrochemical potential (-3.04 V vs the standard hydrogen electrode). Nevertheless, the behavior of Li metal in different environments has been scarcely reported. Read More

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http://dx.doi.org/10.1002/adma.202002550DOI Listing

Training prostate cancer survivors and caregivers to be peer navigators: a blended online/in-person competency-based training program.

Support Care Cancer 2020 Jul 2. Epub 2020 Jul 2.

Division of Health Services and Policy, School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Purpose: Cancer navigation improves access to support and reduces barriers to care; however, appropriate training of navigators is essential. We developed the TrueNTH Peer Navigation Training Program (PNTP), a competency-based, blended online/in-person course. In this study, we evaluate the feasibility, acceptability, and effectiveness of the PNTP among prostate cancer (PC) survivors (patients, caregivers). Read More

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http://dx.doi.org/10.1007/s00520-020-05586-8DOI Listing

Effectiveness of school-based health promotion interventions prioritized by stakeholders from health and education sectors: A systematic review and meta-analysis.

Prev Med Rep 2020 Sep 1;19:101138. Epub 2020 Jun 1.

School of Public Health, University of Alberta, Edmonton, Canada.

Childhood obesity and associated modifiable risk factors exert significant burden on the health care system. The goal of this systematic review and meta-analysis was to examine the effectiveness of school-based intervention types perceived by Canadian stakeholders in health and education as feasible, acceptable and sustainable in terms of improving physical activity (PA), fruit and vegetable intake, and body weight. We searched multiple databases for studies that evaluated school-based interventions to prevent obesity and associated risk factors (i. Read More

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http://dx.doi.org/10.1016/j.pmedr.2020.101138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322344PMC
September 2020

Pivoting for a Pandemic.

Authors:
Tania Mysak

Can J Hosp Pharm 2020 May-Jun;73(3):240. Epub 2020 Jun 1.

, BSP, PharmD, is President and Vision Liaison for the Canadian Society of Hospital Pharmacists.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308156PMC

Pharmacy Leadership during the COVID-19 Pandemic.

Authors:
Peter J Zed

Can J Hosp Pharm 2020 May-Jun;73(3):173-174. Epub 2020 Jun 1.

, BSc, BSc(Pharm), ACPR, PharmD, FCSHP, is Professor and Associate Dean, Practice Innovation, Faculty of Pharmaceutical Sciences, and Associate Member, Department of Emergency Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia. He is also an Associate Editor with the Canadian Journal of Hospital Pharmacy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308150PMC

Cannabinoids and an anti-inflammatory diet for the treatment of neuropathic pain after spinal cord injury (The CATNP Study): study protocol for a randomized controlled trial.

Spinal Cord 2020 Jul 1. Epub 2020 Jul 1.

Lawson Health Research Institute, London, ON, Canada.

Study Design: Multicenter, randomized, double-blind, placebo controlled, clinical trial.

Objective: The objective of this paper is to evaluate the effectiveness of cannabinoids and an anti-inflammatory diet, alone and in combination, for the management of neuropathic pain (NP) after spinal cord injury (SCI).

Setting: Two Canadian SCI rehabilitation centers. Read More

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http://dx.doi.org/10.1038/s41393-020-0508-5DOI Listing

The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada.

J Geriatr Oncol 2020 Jun 28. Epub 2020 Jun 28.

Division of Medical Oncology, Sunnybrook Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; ICES Central, Toronto, Ontario, Canada.

Purpose: The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study.

Methods: We used health administrative data collected from post-menopausal women (aged ≥66 years) who were diagnosed with breast cancer and started on adjuvant endocrine therapy from 2005 to 2012 with follow-up until 2017. Read More

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http://dx.doi.org/10.1016/j.jgo.2020.05.009DOI Listing

Effectiveness of reminders to sustain practice change among direct care providers in residential care facilities: a cluster randomized controlled trial.

Implement Sci 2020 Jul 1;15(1):51. Epub 2020 Jul 1.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Background: The study purpose was to compare the effectiveness of monthly or quarterly peer reminder knowledge translation interventions, with monthly or quarterly paper-based reminders, to sustain a mobility innovation, the sit-to-stand activity.

Method: A cluster RCT using a stratified 2 × 2 factorial design was conducted in 24 Canadian residential care facilities with 416 residents and 54 peer reminder care aides. The 1-year intervention included two intensities of reminders (high: socially based peer reminders delivered by volunteer care aides to other care aides; low: paper-based reminders posted in residents' rooms), at two frequencies (monthly; every 3 months). Read More

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http://dx.doi.org/10.1186/s13012-020-01012-zDOI Listing

The influence of income on medical school admissions in Canada: a retrospective cohort study.

BMC Med Educ 2020 Jul 1;20(1):209. Epub 2020 Jul 1.

Michael G. DeGroote School of Medicine Waterloo Regional Campus, McMaster University, 10 Victoria Street South, Kitchener, N2G 1C5, Canada.

Background: The socioeconomic status of applicants to Canadian medical schools has been understudied in the past two decades. Institutional efforts have been made to address the lack of socioeconomic diversity across Canada during this time. We investigated the income characteristics of medical school applicants, as well as the relationship between applicant income and offer of admission, to characterize the current state of socioeconomic diversity in medical admissions. Read More

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http://dx.doi.org/10.1186/s12909-020-02126-0DOI Listing

The law and problematic marketing by private umbilical cord blood banks.

BMC Med Ethics 2020 Jul 1;21(1):52. Epub 2020 Jul 1.

Health Law Institute, Faculty of Law, University of Alberta, Edmonton, Alberta, T6G 2H5, Canada.

Background: Private umbilical cord blood banking is a for-profit industry in which parents pay to store blood for potential future use. Governments have noted the tendency for private banks to oversell the potential for cord blood use, especially in relation to speculative cell therapies not yet supported by clinical evidence. We assessed the regulatory landscape governing private cord bank marketing in Canada. Read More

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http://dx.doi.org/10.1186/s12910-020-00494-2DOI Listing

Development Time and Patent Extension for Prescription Drugs in Canada: A Cohort Study.

Authors:
Joel Lexchin

Int J Health Policy Manag 2020 Jun 23. Epub 2020 Jun 23.

School of Health Policy and Management, York University, Toronto, ON, Canada.

The Comprehensive Economic and Trade Agreement between Canada and the European Union provides for an extension of Canadian patents for prescription drugs by up to 2 years. One of the arguments advanced for longer patent time is to compensate companies for the length of the overall drug development time (the time between patent application and market approval). This study investigates overall development time in Canada for different groups of drugs approved between January 1, 2009 and December 31, 2018 and how many of these drugs are eligible for up to 2 years of patent term extension. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.100DOI Listing

Understanding the Battle for Universal Pharmacare in Canada Comment on "Universal Pharmacare in Canada".

Int J Health Policy Manag 2020 Mar 14. Epub 2020 Mar 14.

School of Public Policy and Administration, Carleton University, Ottawa, ON, Canada.

Drug coverage in Canada is a patchwork; an inequitable inefficient and unsustainable patchwork with no coherence or purpose. Some people think that we can solve the problem by adding more patches, but the core of the problem is that it is a patchwork. For the working population, access to medicines is still organized as privileges offered by employers to their employees. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.40DOI Listing

Cultivating Value Co-Creation in Health System Research Comment on "Experience of Health Leadership in Partnering with University-Based Researchers in Canada - A Call to Re-imagine Research".

Int J Health Policy Manag 2020 Mar 11. Epub 2020 Mar 11.

School of Nursing and Midwifery, Faculty of Health, Deakin University, Geelong, VIC, Australia.

Partnerships have various purposes and exist in many configurations. Although there has been a refocusing in health system research on forming strategic partnerships between researchers and knowledge users (KUs) to maximise the relevance and uptake of research in practice; research knowledge frequently fails to reach KUs nor impact the community served. Whilst there have been many attempts to engage KUs, researchers and decisionmakers often promote a top down approach that has lacked insight into KUs' specific needs and values. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.35DOI Listing

Promising Points for Intervention in Re-Imagining Partnered Research in Health Services Comment on "Experience of Health Leadership in Partnering with University-Based Researchers in Canada - A Call to 'Re-imagine' Research".

Int J Health Policy Manag 2020 Feb 19. Epub 2020 Feb 19.

School of Health Studies, Faculty of Health Sciences, Western University, London, ON, Canada.

In this commentary, we respond to Bowen and colleagues' empirical study of research partnerships between Canadian health organizations and university-based investigators. We draw on our experiences of university and health-services partnerships to elaborate on some of the misalignments between researchers and health services leaders identified by Bowen et al. We take up Bowen and colleagues' call to re-imagine research by proposing three promising points of intervention in research partnerships. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.24DOI Listing
February 2020

The Challenges of Canadian Pharmacare Are More Complicated Than Acknowledged Comment on "Pharmacare in Canada".

Int J Health Policy Manag 2020 Feb 15. Epub 2020 Feb 15.

Department of Economics and Business, Colorado College, Colorado Springs, CO, USA.

This commentary considers two editorial pieces, written by Hajizadeh and Edmonds, and Lewis, which address universal pharmacare in Canada. The pieces focus on the social inequities of the existing system and the challenges of successful implementation. After identifying the significant strengths of both articles, this commentary then delves into the reasons why universal pharmacare may not be the solution, and identifies numerous thorny issues that will complicate the implementation of such a publicly funded program. Read More

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http://dx.doi.org/10.15171/ijhpm.2020.20DOI Listing
February 2020

Advancing Health Services Collaborative and Partnership Research Comment on "Experience of Health Leadership in Partnering with University-Based Researchers in Canada - A Call to 'Re-imagine' Research".

Int J Health Policy Manag 2020 Feb 15. Epub 2020 Feb 15.

Department of Learning, Informatics, Management and Ethics (LIME), Medical Management Centre, SOLIID, Karolinska Institutet, Stockholm, Sweden.

Bowen et al highlight the trend towards partnership research to address the complex challenges currently facing healthcare systems and organizations world-wide. They focus on important strategic actors in partner organizations and their experiences, views and advice for sustainable collaboration, within a Canadian context. The authors call for a multi-system change to provide better conditions for research partnerships. Read More

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http://dx.doi.org/10.15171/ijhpm.2020.16DOI Listing
February 2020

Re-Framing the Knowledge to Action Challenge Through NIHR Knowledge Mobilisation Research Fellows Comment on "CIHR Health System Impact Fellows: Reflections on 'Driving Change' Within the Health System".

Int J Health Policy Manag 2020 Jan 15. Epub 2020 Jan 15.

Lab4Living, Art & Design Research Centre, Sheffield Hallam University, Sheffield, UK.

The ambition of the Canadian Institutes for Health Research Health System Impact (HSI) Fellowship initiative to modernise the health system is impressive. Embedded researchers who work between academia and nonacademic settings offer an opportunity to reframe the problem of evidence uptake as a product of a gap between those who produce knowledge and those who use it. As such, there has been an increasing interest in the potential of people in embedded research roles to work with stakeholders in the co-production of knowledge to address service challenges. Read More

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http://dx.doi.org/10.15171/ijhpm.2020.02DOI Listing
January 2020

National Pharmacare in Canada: Equality or Equity, Accessibility or Affordability Comment on "Universal Pharmacare in Canada: A Prescription for Equity in Healthcare".

Authors:
Nigel S B Rawson

Int J Health Policy Manag 2020 Jan 1. Epub 2020 Jan 1.

Eastlake Research Group, Oakville, ON, Canada.

Canada's federal government intends to take steps to implement national pharmacare so that all Canadians have prescription drug coverage they need at an affordable price. Relatively limited funds have so far been pledged to support national pharmacare, which raises the question: what kind of program is envisioned? Since the government has already introduced regulations intended to reduce new drug prices drastically, national pharmacare seems likely to be a basic system designed to assist low-income Canadians with accessing primary care medicines. What Canadians actually need is a system that provides access to the medicine considered appropriate by the patient and their healthcare provider for the patient's specific condition. Read More

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http://dx.doi.org/10.15171/ijhpm.2019.146DOI Listing
January 2020

Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice.

Neuropsychopharmacology 2020 Jul 1. Epub 2020 Jul 1.

Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada.

Schizophrenia is a debilitating disorder affecting young adults displaying symptoms of cognitive impairment, anxiety, and early social isolation prior to episodes of auditory hallucinations. Cannabis use has been tied to schizophrenia-like symptoms, indicating that dysregulated endogenous cannabinoid signaling may be causally linked to schizophrenia. Previously, we reported that glutamatergic neuron-selective ablation of Lmo4, an endogenous inhibitor of the tyrosine phosphatase PTP1B, impairs endocannabinoid (eCB) production from the metabotropic glutamate receptor mGluR5. Read More

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http://dx.doi.org/10.1038/s41386-020-0755-3DOI Listing

Guideline Recommendations for Oral Care After Acquired Brain Injury: Protocol for a Systematic Review.

JMIR Res Protoc 2020 Jul 1;9(7):e17249. Epub 2020 Jul 1.

School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Background: Oral care is important to prevent buccal and systemic infections after an acquired brain injury (ABI). Despite recent advancements in the development of ABI clinical practice guidelines, recommendations for specific clinical processes and actions to attain adequate oral care often lack information.

Objective: This systematic review will (1) identify relevant ABI clinical practice guidelines and (2) appraise the oral care recommendations existing in the selected guidelines. Read More

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http://dx.doi.org/10.2196/17249DOI Listing

Phenotyping Plant Cellular and Tissue Level Responses to Cold with Synchrotron-Based Fourier-Transform Infrared Spectroscopy and X-Ray Computed Tomography.

Methods Mol Biol 2020 ;2156:141-159

Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK, Canada.

Despite the extensive use of synchrotron radiation in material and biomedical sciences, it has only recently been utilized to expand our understanding of plant responses to environmental stress. Recent advances have led to the development of phenotyping platforms to identify chemical and morphological differences in breeding plant material. While these methodologies are applicable for and tested with a variety of abiotic and biotic stresses, they are particularly useful as a first step to identify cold-induced chemical and morphological changes in plants. Read More

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http://dx.doi.org/10.1007/978-1-0716-0660-5_11DOI Listing
January 2020

Role Incongruence and Psychological Stress Symptoms in Substitute Decision Makers of Intensive Care Patients.

Am J Crit Care 2020 Jul;29(4):301-310

Jan O. Friedrich is an intensivist in the Critical Care Department at St Michael's Hospital, a scientist at Li Ka Shing Knowledge Institute, and associate professor in the Interdepartmental Division of Critical Care, University of Toronto.

Background: Most intensive care patients require substitute decision makers (SDMs) to make decisions. The SDMs may prefer an active, shared, or passive decision-making role. Role incongruence is when preferred and actual roles differ. Read More

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http://dx.doi.org/10.4037/ajcc2020307DOI Listing

Comparative Study of Two Short-Form Versions of the Montreal Cognitive Assessment for Screening of Post-Stroke Cognitive Impairment in a Chinese Population.

Clin Interv Aging 2020 18;15:907-914. Epub 2020 Jun 18.

Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Purpose: Cognitive impairment (CI) is one of the most significant post-stroke complications. The Montreal Cognitive Assessment (MoCA) is widely applied to the early screening of post-stroke CI (PSCI), and has good sensitivity and specificity, but needs a long time to administer. Clinicians and researchers need shorter, more effective cognitive testing tools. Read More

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http://dx.doi.org/10.2147/CIA.S248856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308117PMC

Use of cell fusion proteins to enhance adenoviral vector efficacy as an anti-cancer therapeutic.

Cancer Gene Ther 2020 Jul 1. Epub 2020 Jul 1.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Oncolytic viruses are designed to replicate in and kill cancer cells, and have shown tremendous promise in preclinical and clinical studies. Indeed, several oncolytic viruses are available to patients in a number of different countries around the world. However, most oncolytic viruses show a poor ability to spread throughout the tumor mass, frequently leading to only a partial response and regrowth of the tumor. Read More

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http://dx.doi.org/10.1038/s41417-020-0192-9DOI Listing

Post-stroke impairment and recovery are predicted by task-specific regionalization of injury.

J Neurosci 2020 Jun 30. Epub 2020 Jun 30.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa

Lesion size and location affect the magnitude of impairment and recovery following stroke, but the precise relationship between these variables and functional outcome is unknown. Herein, we systematically varied the size of strokes in motor cortex and surrounding regions to assess effects on impairment and recovery of function. Female Sprague Dawley rats (N=64) were evaluated for skilled reaching, spontaneous limb use, and limb placement over a 7-week period post-stroke. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0057-20.2020DOI Listing

The bioavailability of ingested Al-labelled aluminium and aluminium compounds in the rat.

Neurotoxicology 2020 Jun 27. Epub 2020 Jun 27.

PRIME Laboratory, Purdue University, 525 Northwestern Avenue, West Lafayette, Indiana, 47907-2036, USA.

The fractional uptake of ingested aluminium and aluminium compounds (aluminium citrate, aluminium nitrate, aluminium chloride, aluminium sulphate, aluminium hydroxide, aluminium oxide, aluminium metal, powdered aluminium pot electrolyte, acidic sodium aluminium phosphate (SALP), basic sodium aluminium phosphate (Kasal), sodium aluminium silicate and FD&C red 40 aluminium lake) from the gastro-intestinal tract of adult female rats was measured. This was determined by comparing retained body burden of Al at seven days post-admistration of an i.v. Read More

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http://dx.doi.org/10.1016/j.neuro.2020.06.010DOI Listing

Expanding the 3 Wishes Project for compassionate end-of-life care: a qualitative evaluation of local adaptations.

BMC Palliat Care 2020 Jun 30;19(1):93. Epub 2020 Jun 30.

Departments of Medicine and Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: The 3 Wishes Project (3WP) is an end-of-life program that honors the dignity of dying patients by fostering meaningful connections among patients, families, and clinicians. Since 2013, it has become embedded in the culture of end-of-life care in over 20 ICUs across North America. The purpose of the current study is to describe the variation in implementation of 3WP across sites, in order to ascertain which factors facilitated multicenter implementation, which factors remain consistent across sites, and which may be adapted to suit local needs. Read More

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http://dx.doi.org/10.1186/s12904-020-00601-5DOI Listing
June 2020
1.787 Impact Factor

Dietary Patterns Are Associated with Risk of Prostate Cancer in a Population-Based Case-Control Study in Montreal, Canada.

Nutrients 2020 Jun 27;12(7). Epub 2020 Jun 27.

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, University of Quebec, Laval, QC H7V 1B7, Canada.

This study describes the association between dietary patterns and prostate cancer (PCa) risk in a population-based case-control study conducted in Montreal, Canada (2005-2012). Cases ( = 1919) were histologically confirmed, aged ≤75 years. Concomitantly, controls ( = 1991) were randomly selected from the electoral list and frequency-matched to cases by age (±5 years). Read More

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http://dx.doi.org/10.3390/nu12071907DOI Listing

The case of the Guru Nanak Emergency Services Department: Sikh therapeutic geographies.

Authors:
Arlene Macdonald

Soc Sci Med 2020 Jun 22;259:113144. Epub 2020 Jun 22.

Institute for the Medical Humanities, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-1311, USA. Electronic address:

Why, in the early 21st century, has a publicly funded, publicly operated Canadian hospital incorporated the founding figure of the Sikh religion into its architecture and its identity? Drawing on qualitative research, this paper argues that the Guru Nanak Emergency Department is not an extension of the old tradition of naming hospitals after religious figures, but rather a novel development arising from the "super-diversity" of contemporary cities, the "spiritualizing" of healthcare ecologies, and the vigorous actions of Sikhs attempting to remedy social wounds and build 'healthy spaces' in the pluralistic urban environs they are part of. A new therapeutic geography is emergent; the Guru Nanak Emergency Department signals new trajectories of care propagated by the lively interrelations of spiritualized healthcare ecologies, precarious and mobile religious minorities, and the city that houses them both. Read More

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http://dx.doi.org/10.1016/j.socscimed.2020.113144DOI Listing

Leptin mediates improvements in cognitive function following treatment with infliximab in adults with bipolar depression.

Psychoneuroendocrinology 2020 Jun 20;120:104779. Epub 2020 Jun 20.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

A potential role for leptin in the pathophysiology of bipolar disorder (BD) has been proposed. We recently investigated the effects of the tumor necrosis factor-alpha (TNF-α) antagonist infliximab in individuals with bipolar depression. Leptin is known to interact with the TNF-α system. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104779DOI Listing

Early operative management in patients with adhesive small bowel obstruction: population-based cost analysis.

BJS Open 2020 Jun 30. Epub 2020 Jun 30.

Division of General Surgery, Department of Surgery, Toronto, Ontario, Canada.

Background: Adhesive small bowel obstruction (aSBO) is a potentially recurrent disease. Although non-operative management is often successful, it is associated with greater risk of recurrence than operative intervention, and may have greater downstream morbidity and costs. This study aimed to compare the current standard of care, trial of non-operative management (TNOM), and early operative management (EOM) for aSBO. Read More

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http://dx.doi.org/10.1002/bjs5.50311DOI Listing

Platelet autoantibodies in the bone marrow of patients with immune thrombocytopenia.

Blood Adv 2020 Jul;4(13):2962-2966

Department of Medicine, Michael G. DeGroot School of Medicine and.

Autoantibodies cause platelet destruction in patients with immune thrombocytopenia (ITP); yet only 50% to 60% of patients have detectable platelet autoantibodies in peripheral blood. We hypothesized that in some ITP patients, platelet autoantibodies are sequestered in the bone marrow where pathological immune reactions target megakaryocytes or newly formed platelets. In this study, we modified the platelet glycoprotein-specific assay to test bone marrow aspiration samples for free platelet autoantibodies or antibodies bound to bone marrow cells in aspirate fluid from patients with ITP (n = 18), patients with nonimmune thrombocytopenia (n = 3), and healthy donors (n = 6). Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001846DOI Listing

SPORTS STARS: a practitioner-led, peer-group sports intervention for ambulant children with cerebral palsy. Activity and participation outcomes of a randomised controlled trial.

Disabil Rehabil 2020 Jun 30:1-9. Epub 2020 Jun 30.

School of Health & Rehabilitation Sciences, The University of Queensland, St Lucia, Australia.

To investigate the effectiveness of a practitioner-led, peer-group sports intervention for children with CP at GMFCS Level I-II. Children with CP (GMFCS I-II; 6-12 years) were randomised to or waitlist-control groups. included eight-weeks (eight hours) of physiotherapist-led, sports-specific gross motor activity training, sports education, teamwork development and confidence building. Read More

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http://dx.doi.org/10.1080/09638288.2020.1783376DOI Listing

Design and Implementation of a Distant-Learning Clinical Research Mentorship Program: The Accra-Toronto Collaboration.

JCO Glob Oncol 2020 Jun;6:919-928

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Purpose: For many oncology training programs in low- and middle-income countries, dedicated time for research education and mentorship of trainees is limited. Here, we report a 1-year-long collaboration between a cancer center in Canada and one in Ghana with the aim of imparting clinical research skills and mentoring the research of radiation oncology residents.

Methods: On the basis of a needs assessment conducted in Ghana, we designed a curriculum consisting of 13 weekly seminars delivered via videoconference, followed by a 1-year-long mentorship program to support research projects. Read More

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http://dx.doi.org/10.1200/JGO.19.00240DOI Listing

Anaemia, iron deficiency and heart failure in 2020: facts and numbers.

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology & Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Charité-Universitätsmedizin Berlin (Campus CVK), Berlin, Germany.

Anaemia is defined by WHO as Hb < 13.0 g/dL in male adults and <12.0 g/dL in female adults. Read More

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http://dx.doi.org/10.1002/ehf2.12797DOI Listing

An alternate level of care plan: Co-designing components of an intervention with patients, caregivers and providers to address delayed hospital discharge challenges.

Health Expect 2020 Jun 30. Epub 2020 Jun 30.

Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, Toronto, ON, Canada.

Objective: To engage with patients, caregivers and care providers to co-design components of an intervention that aims to improve delayed hospital discharge experiences.

Design: This is a qualitative study, which entailed working groups and co-design sessions utilizing World Café and deliberative dialogue techniques to continually refine the intervention.

Setting And Participants: Our team engaged with 61 participants (patients, caregivers and care providers) in urban and rural communities across Ontario, Canada. Read More

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http://dx.doi.org/10.1111/hex.13094DOI Listing

Demographic population structure of black howler monkeys in fragmented and continuous forest in Chiapas, Mexico: Implications for conservation.

Am J Primatol 2020 Jun 30:e23163. Epub 2020 Jun 30.

Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City, Mexico.

For wild primates, demography studies are increasingly recognized as necessary for assessing the viability of vulnerable populations experiencing rapid environmental change. In particular, anthropogenic changes such as habitat loss and fragmentation can cause ecological and behavioral changes in small, isolated populations, which may, over time, alter population density and demographic structure (age/sex classes and group composition) in fragment populations relative to continuous forest populations. We compared our study population of Endangered black howler monkeys (Alouatta pigra) in 34 forest fragments around Palenque National Park (PNP), Mexico (62 groups, 407 individuals), to the adjacent population in PNP, protected primary forest (21 groups, 134 individuals), and to previous research on black howlers in fragments in our study area (18 groups, 115 individuals). Read More

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http://dx.doi.org/10.1002/ajp.23163DOI Listing