127,688 results match your criteria Canadian Journal Of Mathematics-journal Canadien De Mathematiques[Journal]


Variability in patient sociodemographics, clinical characteristics, and healthcare service utilization among 107,302 treatment seeking smokers in Ontario: A cross-sectional comparison.

PLoS One 2020 10;15(7):e0235709. Epub 2020 Jul 10.

Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Background: Since 2005, the Smoking Treatment for Ontario Patients (STOP) program has provided smoking cessation treatment of varying form and intensity to smokers through 11 distinct treatment models, either in-person at partnering healthcare organizations or remotely via web or telephone. We aimed to characterize the patient populations reached by different treatment models.

Methods: We linked self-report data to health administrative databases to describe sociodemographics, physical and mental health comorbidity, healthcare utilization and costs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235709PLOS

Mechanistic understanding of underperforming enteric coated products: Opportunities to add clinical relevance to the dissolution test.

J Control Release 2020 Jul 7. Epub 2020 Jul 7.

Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Over the last 70 years several cases of in vivo failure of enteric coated (EC) formulations have been reported. The observed failures seem to be due to the slower than expected in vivo performance of EC products. Upon reaching the intestinal lumen, the dosage form is exposed to a bicarbonate buffered environment at much lower interfacial buffering capacity compared to those applied in compendial phosphate buffers. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.031DOI Listing

Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer.

Pharmacogenet Genomics 2020 Jul 8. Epub 2020 Jul 8.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Objective: Based on our previous findings that postmenopausal women with estrone (E1) and estradiol (E2) concentrations at or above 1.3 pg/ml and 0.5 pg/ml, respectively, after 6 months of adjuvant anastrozole therapy had a three-fold risk of recurrence, we aimed to identify a single-nucleotide polymorphism (SNP)-based model that would predict elevated E1 and E2 and then validate it in an independent dataset. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000415DOI Listing

The Impact of Coronavirus Disease 2019 Pandemic on U.S. and Canadian PICUs.

Pediatr Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

Virtual Pediatric Systems (VPS), LLC, Los Angeles, CA.

Objectives: There are limited reports of the impact of the coronavirus disease 2019 pandemic focused on U.S. and Canadian PICUs. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002510DOI Listing

Rapid Micro-induction of Buprenorphine/Naloxone for Opioid Use Disorder in a Critically ill Intubated Patient: A Case Report.

J Addict Med 2020 Jul 7. Epub 2020 Jul 7.

BC Centre on Substance Use, Canada (BH, JH), Foundry Central Office, University of British Columbia, Vancouver General Hospital, Complex Pain and Addiction Services, Canada (PR-A), Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Canada (DG).

Background: Buprenorphine/naloxone has been shown to be an effective treatment of opioid use disorder. According to the Canadian National clinical practice guideline on the management of opioid use disorders, given the superior safety profile of buprenorphine/naloxone and its potential for flexible take-home dosing in comparison to other opioid agonist medication it is strongly recommended to initiate opioid agonist treatment with buprenorphine/naloxone as the preferred first-line treatment when possible. Due to its pharmacological properties induction can be challenging, requiring the cessation of all opioids for a certain amount of time to avoid the risk of precipitated withdrawal symptoms. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000675DOI Listing

Processing method modulates the effectiveness of black beans for lowering blood cholesterol in spontaneously hypertensive rats.

J Sci Food Agric 2020 Jul 10. Epub 2020 Jul 10.

Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Science, University of Manitoba, Winnipeg, MB, Canada, R3T 2N2.

Background: Various foods are known to have beneficial effects on health when consumed whole, however, there is a trend to prepare foods from processed ingredients, and it remains unclear whether the benefits of the whole food are retained. Therefore, the purpose of this study was to examine whether different processing techniques affect the cholesterol-lowering and vascular effects of black beans (Phaseolus vulgaris L.). Read More

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http://dx.doi.org/10.1002/jsfa.10654DOI Listing

Combined Biologic and Immunomodulatory Therapy is Superior to Monotherapy for Decreasing the Risk of Inflammatory Bowel Disease-Related Complications.

J Crohns Colitis 2020 Jul 10. Epub 2020 Jul 10.

Department of Community Health & Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Background And Aims: The combination of infliximab and azathioprine is more efficacious than either therapy alone for Crohn's disease [CD] and ulcerative colitis [UC]. However, it is uncertain whether these benefits extend to real-world clinical practice and to other combinations of biologics and immunomodulators.

Methods: We collected health administrative data from four Canadian provinces representing 78 413 patients with inflammatory bowel disease [IBD] of whom 11 244 were prescribed anti-tumour necrosis factor [anti-TNF] agents. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa050DOI Listing

Ancillary Testing for Determination of Death by Neurologic Criteria Around the World.

Neurocrit Care 2020 Jul 9. Epub 2020 Jul 9.

Boston University School of Medicine, 72 East Concord Street, Collamore 3, Suite 338, Boston, USA.

Objective: We sought to identify similarities and differences in the diagnostic requirements for ancillary testing for determination of brain death/death by neurologic criteria (BD/DNC) around the world.

Methods: We reviewed diagnostic requirements for ancillary testing for BD/DNC in 78 unique official national BD/DNC protocols obtained from contacts worldwide between January 2018 and April 2019.

Results: Details provided on the performance and interpretation of ancillary tests for determination of BD/DNC were variably provided and inconsistent. Read More

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http://dx.doi.org/10.1007/s12028-020-01039-6DOI Listing

Combination HIV Prevention Strategies Among Montreal Gay, Bisexual, and Other Men Who Have Sex with Men in the PrEP Era: A Latent Class Analysis.

AIDS Behav 2020 Jul 9. Epub 2020 Jul 9.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.

Pre-exposure prophylaxis (PrEP) became publicly available in Quebec for gay, bisexual and other men who have sex with men (GBM) in 2013. We used baseline data from Engage, a cohort of GBM recruited by respondent-driven sampling, to examine patterns of combination HIV prevention use among Montreal GBM since PrEP became available. Latent class analysis, stratified by HIV status, was used to categorize GBM by self-reported use of biomedical and behavioural prevention strategies. Read More

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http://dx.doi.org/10.1007/s10461-020-02965-4DOI Listing

A comparison of floor surfaces for injury prevention in care settings: impact forces and horizontal pulling force required to move wheeled equipment.

Osteoporos Int 2020 Jul 9. Epub 2020 Jul 9.

School of Engineering, Cardiff University Queen's Buildings, The Parade, Cardiff, CF24 3AA, UK.

Shock-absorbing flooring is one potential solution to prevent fall-related injuries. No standards exist to characterize shock-absorbing healthcare flooring. This study explores two mechanical tests for impact force reduction and horizontal force required to move wheeled objects. Read More

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http://dx.doi.org/10.1007/s00198-020-05520-yDOI Listing

Eco-friendly synthesis of functionalized chitosan-based nanoantibiotic system for potential delivery of linezolid as antimicrobial agents.

Saudi Pharm J 2020 Jul 18;28(7):859-868. Epub 2020 Jun 18.

Institute of Nanoscience & Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt.

To obtain a healthy human being with beneficial microflora against different pathogenic infections, classical antibiotics with nanosized biomaterials were used to inhibit the growth of bacterium by their potent synergistic effect. Hence, this study planned to load an oxazolidinone antibiotic named linezolid (LD) onto functionalized chitosan (CN) with 3, 5- dinitrosalyslic acid (DA) via microwave synthesis without harsh condition. The exploring synergistic effect of linezolid (LD) with CN/DA controllable nanostructure was compact efflux-mediated methicillin-resistant (MRSA) burden and other selected bactericide Gram-positive ( Gram-negative (), and . Read More

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http://dx.doi.org/10.1016/j.jsps.2020.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335826PMC

The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data.

Authors:
Gilberto Pastorello Carlo Trotta Eleonora Canfora Housen Chu Danielle Christianson You-Wei Cheah Cristina Poindexter Jiquan Chen Abdelrahman Elbashandy Marty Humphrey Peter Isaac Diego Polidori Alessio Ribeca Catharine van Ingen Leiming Zhang Brian Amiro Christof Ammann M Altaf Arain Jonas Ardö Timothy Arkebauer Stefan K Arndt Nicola Arriga Marc Aubinet Mika Aurela Dennis Baldocchi Alan Barr Eric Beamesderfer Luca Belelli Marchesini Onil Bergeron Jason Beringer Christian Bernhofer Daniel Berveiller Dave Billesbach Thomas Andrew Black Peter D Blanken Gil Bohrer Julia Boike Paul V Bolstad Damien Bonal Jean-Marc Bonnefond David R Bowling Rosvel Bracho Jason Brodeur Christian Brümmer Nina Buchmann Benoit Burban Sean P Burns Pauline Buysse Peter Cale Mauro Cavagna Pierre Cellier Shiping Chen Isaac Chini Torben R Christensen James Cleverly Alessio Collalti Claudia Consalvo Bruce D Cook David Cook Carole Coursolle Edoardo Cremonese Peter S Curtis Ettore D'Andrea Humberto da Rocha Xiaoqin Dai Kenneth J Davis Bruno De Cinti Agnes de Grandcourt Anne De Ligne Raimundo C De Oliveira Nicolas Delpierre Ankur R Desai Carlos Marcelo Di Bella Paul di Tommasi Han Dolman Francisco Domingo Gang Dong Sabina Dore Pierpaolo Duce Eric Dufrêne Allison Dunn Jiří Dušek Derek Eamus Uwe Eichelmann Hatim Abdalla M ElKhidir Werner Eugster Cacilia M Ewenz Brent Ewers Daniela Famulari Silvano Fares Iris Feigenwinter Andrew Feitz Rasmus Fensholt Gianluca Filippa Marc Fischer John Frank Marta Galvagno Mana Gharun Damiano Gianelle Bert Gielen Beniamino Gioli Anatoly Gitelson Ignacio Goded Mathias Goeckede Allen H Goldstein Christopher M Gough Michael L Goulden Alexander Graf Anne Griebel Carsten Gruening Thomas Grünwald Albin Hammerle Shijie Han Xingguo Han Birger Ulf Hansen Chad Hanson Juha Hatakka Yongtao He Markus Hehn Bernard Heinesch Nina Hinko-Najera Lukas Hörtnagl Lindsay Hutley Andreas Ibrom Hiroki Ikawa Marcin Jackowicz-Korczynski Dalibor Janouš Wilma Jans Rachhpal Jassal Shicheng Jiang Tomomichi Kato Myroslava Khomik Janina Klatt Alexander Knohl Sara Knox Hideki Kobayashi Georgia Koerber Olaf Kolle Yoshiko Kosugi Ayumi Kotani Andrew Kowalski Bart Kruijt Julia Kurbatova Werner L Kutsch Hyojung Kwon Samuli Launiainen Tuomas Laurila Bev Law Ray Leuning Yingnian Li Michael Liddell Jean-Marc Limousin Marryanna Lion Adam J Liska Annalea Lohila Ana López-Ballesteros Efrén López-Blanco Benjamin Loubet Denis Loustau Antje Lucas-Moffat Johannes Lüers Siyan Ma Craig Macfarlane Vincenzo Magliulo Regine Maier Ivan Mammarella Giovanni Manca Barbara Marcolla Hank A Margolis Serena Marras William Massman Mikhail Mastepanov Roser Matamala Jaclyn Hatala Matthes Francesco Mazzenga Harry McCaughey Ian McHugh Andrew M S McMillan Lutz Merbold Wayne Meyer Tilden Meyers Scott D Miller Stefano Minerbi Uta Moderow Russell K Monson Leonardo Montagnani Caitlin E Moore Eddy Moors Virginie Moreaux Christine Moureaux J William Munger Taro Nakai Johan Neirynck Zoran Nesic Giacomo Nicolini Asko Noormets Matthew Northwood Marcelo Nosetto Yann Nouvellon Kimberly Novick Walter Oechel Jørgen Eivind Olesen Jean-Marc Ourcival Shirley A Papuga Frans-Jan Parmentier Eugenie Paul-Limoges Marian Pavelka Matthias Peichl Elise Pendall Richard P Phillips Kim Pilegaard Norbert Pirk Gabriela Posse Thomas Powell Heiko Prasse Suzanne M Prober Serge Rambal Üllar Rannik Naama Raz-Yaseef David Reed Victor Resco de Dios Natalia Restrepo-Coupe Borja R Reverter Marilyn Roland Simone Sabbatini Torsten Sachs Scott R Saleska Enrique P Sánchez-Cañete Zulia M Sanchez-Mejia Hans Peter Schmid Marius Schmidt Karl Schneider Frederik Schrader Ivan Schroder Russell L Scott Pavel Sedlák Penélope Serrano-Ortíz Changliang Shao Peili Shi Ivan Shironya Lukas Siebicke Ladislav Šigut Richard Silberstein Costantino Sirca Donatella Spano Rainer Steinbrecher Robert M Stevens Cove Sturtevant Andy Suyker Torbern Tagesson Satoru Takanashi Yanhong Tang Nigel Tapper Jonathan Thom Frank Tiedemann Michele Tomassucci Juha-Pekka Tuovinen Shawn Urbanski Riccardo Valentini Michiel van der Molen Eva van Gorsel Ko van Huissteden Andrej Varlagin Joseph Verfaillie Timo Vesala Caroline Vincke Domenico Vitale Natalia Vygodskaya Jeffrey P Walker Elizabeth Walter-Shea Huimin Wang Robin Weber Sebastian Westermann Christian Wille Steven Wofsy Georg Wohlfahrt Sebastian Wolf William Woodgate Yuelin Li Roberto Zampedri Junhui Zhang Guoyi Zhou Donatella Zona Deb Agarwal Sebastien Biraud Margaret Torn Dario Papale

Sci Data 2020 Jul 9;7(1):225. Epub 2020 Jul 9.

DIBAF, University of Tuscia, Viterbo, 01100, Italy.

The FLUXNET2015 dataset provides ecosystem-scale data on CO, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability across sites. Read More

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http://dx.doi.org/10.1038/s41597-020-0534-3DOI Listing

The International Bathymetric Chart of the Arctic Ocean Version 4.0.

Sci Data 2020 Jul 9;7(1):176. Epub 2020 Jul 9.

Greenland Institute of Natural Resources, Nuuk, Greenland.

Bathymetry (seafloor depth), is a critical parameter providing the geospatial context for a multitude of marine scientific studies. Since 1997, the International Bathymetric Chart of the Arctic Ocean (IBCAO) has been the authoritative source of bathymetry for the Arctic Ocean. IBCAO has merged its efforts with the Nippon Foundation-GEBCO-Seabed 2030 Project, with the goal of mapping all of the oceans by 2030. Read More

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http://dx.doi.org/10.1038/s41597-020-0520-9DOI Listing

A prospective harmonized multicentre DTI study of cerebral white matter degeneration in ALS.

Neurology 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurology, University of Ulm, Ulm, Germany.

Objective: To evaluate progressive white matter (WM) degeneration in ALS.

Methods: Sixty-six patients with ALS and 43 healthy controls were enrolled in a prospective, longitudinal, multicentre study in the Canadian ALS Neuroimaging Consortium (CALSNIC). Participants underwent a harmonized neuroimaging protocol across 4 centres including diffusion tensor imaging (DTI) for assessment of WM integrity. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010235DOI Listing

Long-Term Care Facility Ownership and Acute Hospital Service Use in British Columbia, Canada: A Retrospective Cohort Study.

J Am Med Dir Assoc 2020 Jul 6. Epub 2020 Jul 6.

Community Geriatrics, Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: Previous studies report higher hospitalization rates in for-profit compared with nonprofit long-term care facilities (LTCFs), but have not included staffing data, a major potential confounder. Our objective was to examine the effect of ownership on hospital admission rates, after adjusting for facility staffing levels and other facility and resident characteristics, in a large Canadian province (British Columbia).

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jamda.2020.04.034DOI Listing

Long-Term Outcomes of Complete Revascularization With Percutaneous Coronary Intervention in Acute Coronary Syndromes.

JACC Cardiovasc Interv 2020 Jul;13(13):1557-1567

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.

Objectives: The aim of this study was to evaluate the long-term outcomes of patients with acute coronary syndromes (ACS) with multivessel disease undergoing percutaneous coronary intervention (PCI).

Background: Controversy exists regarding the benefit of multivessel PCI across the spectrum of ACS.

Methods: A total of 9,094 patients with ACS and multivessel disease (≥70% stenosis in 2 or more major epicardial vessels) undergoing PCI from the Alberta COAPT (Contemporary Acute Coronary Syndrome Patients Invasive Treatment Strategies) registry (April 1, 2007, to March 31, 2013) were reviewed. Read More

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http://dx.doi.org/10.1016/j.jcin.2020.04.034DOI Listing

Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI.

J Am Coll Cardiol 2020 Jul;76(2):162-171

Duke Clinical Research Institute, Durham, North Carolina; Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. Electronic address:

Background: The long-term prognostic impact of post-discharge bleeding in the unique population of patients with acute coronary syndrome (ACS) treated without percutaneous coronary intervention (PCI) remains unexplored.

Objectives: The aim of this study was to assess the association between post-discharge bleeding and subsequent mortality after ACS according to index strategy (PCI or no PCI) and to contrast with the association between post-discharge myocardial infarction (MI) and subsequent mortality.

Methods: In a harmonized dataset of 4 multicenter randomized trials (APPRAISE-2 [Apixaban for Prevention of Acute Ischemic Events-2], PLATO [Study of Platelet Inhibition and Patient Outcomes], TRACER [Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome], and TRILOGY ACS [Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes]), the association between post-discharge noncoronary artery bypass graft-related GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) moderate, severe, or life-threatening bleeding (landmark 7 days post-ACS) and subsequent all-cause mortality was evaluated in a time-updated Cox proportional hazards analysis. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.05.031DOI Listing

Correction to: Phylogeography of higher Diptera in glacial and postglacial grasslands in western North America.

BMC Ecol 2020 Jul 9;20(1):38. Epub 2020 Jul 9.

Natural Resource Sciences, McGill University, Macdonald Campus, Ste-Anne-De-Bellevue, QC, H9X 3V9, Canada.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12898-020-00302-wDOI Listing

Patient and caregiver perspectives on early identification for advance care planning in primary healthcare settings.

BMC Fam Pract 2020 Jul 9;21(1):136. Epub 2020 Jul 9.

Cancer Outcomes Research Program, Department of Surgery, Dalhousie University and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

Background: As part of a broader study to improve the capacity for advance care planning (ACP) in primary healthcare settings, the research team set out to develop and validate a computerized algorithm to help primary care physicians identify individuals at risk of death, and also carried out focus groups and interviews with relevant stakeholder groups. Interviews with patients and family caregivers were carried out in parallel to algorithm development and validation to examine (1) views on early identification of individuals at risk of deteriorating health or dying; (2) views on the use of a computerized algorithm for early identification; and (3) preferences and challenges for ACP.

Methods: Fourteen participants were recruited from two Canadian provinces. Read More

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http://dx.doi.org/10.1186/s12875-020-01206-wDOI Listing

Insights from Regulatory Data on Development Needs of Community Pharmacy Professionals.

Pharmacy (Basel) 2020 Jul 7;8(3). Epub 2020 Jul 7.

Registrant Competence, Ontario College of Pharmacists, Toronto, ON M5R 2R4, Canada.

The aim of this study was to use data available to a Canadian health professions regulator (Ontario College of Pharmacists) to identify areas of opportunity where practitioners (pharmacists and pharmacy technicians) could benefit from further development, in order to optimize practice and improve the quality of care. Four de-identified datasets were used to extract themes from areas of jurisprudence (1969 exam records), member practice assessments (2610 records), pharmacy assessments (2024 records) and conduct (640 case records). Outcome measures included performance in examinations and assessments and competency gaps identified in conduct investigations. Read More

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http://dx.doi.org/10.3390/pharmacy8030111DOI Listing

Ranking evidence in substance use and addiction.

Int J Drug Policy 2020 Jul 6;83:102840. Epub 2020 Jul 6.

British Columbia Centre on Substance Use, 1045 Howe Street, Vancouver, BC V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada. Electronic address:

Evidence-based medicine has consistently prized the epistemological value of randomized-controlled trials (RCTs) owing to their methodological advantages over alternative designs such as observational studies. However, there are limitations to RCTs that hinder their ability to study chronic and dynamic conditions such as substance use and addiction. For these conditions, observational studies may provide superior evidence based on methodological and practical strengths. Read More

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http://dx.doi.org/10.1016/j.drugpo.2020.102840DOI Listing

Socio-economic inequalities in lung cancer incidence in Canada, 1992-2010: results from the Canadian Cancer Registry.

Public Health 2020 Jul 6;185:189-195. Epub 2020 Jul 6.

Department of Diagnostic Radiology, Dalhousie University, Canada.

Objectives: Lung cancer is the most commonly diagnosed cancer in Canada. This study aims to assess trends in income and education inequalities in the incidence of lung cancer in Canada.

Study Design: The study design is a time-trend analysis of nationally collected data. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.04.023DOI Listing

Health service utilization in immigrants with multiple sclerosis.

PLoS One 2020 9;15(7):e0234876. Epub 2020 Jul 9.

ICES, Toronto, Ontario, Canada.

Background: Access to neurology specialty care can influence outcomes in individuals with multiple sclerosis (MS), but may vary based on patient sociodemographic characteristics, including immigration status.

Objective: To compare health services utilization in the year of MS diagnosis, one year before diagnosis and two years after diagnosis in immigrants versus long-term residents in Ontario, Canada.

Methods: We identified incident cases of MS among adults aged 20-65 years by applying a validated algorithm to health administrative data in Ontario, Canada, a region with universal health insurance and comprehensive coverage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234876PLOS

Physical activity, screen time and sleep duration: Combined associations with psychosocial health among Canadian children and youth.

Health Rep 2020 Jul;31(5):9-16

Centre for Surveillance and Applied Research, Public Health Agency of Canada, and Division of Cardiac Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario.

Background: Canada recently adopted the 24-Hour Movement Guidelines for Children and Youth (24-Hour Guidelines) for young people aged 5 to 17 years-an international first, providing integrated recommendations for physical activity, sedentary time and sleep. Since the release of the guidelines, very few studies have examined the associations of adherence to the 24-Hour Guidelines with health outcomes-and none focus on psychosocial health. Therefore, the objective of this study was to assess the associations of meeting the 24-Hour Guidelines and their behaviour-specific recommendations with psychosocial health among Canadian children and youth. Read More

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http://dx.doi.org/10.25318/82-003-x202000500002-engDOI Listing

Health-related concerns and precautions during the COVID-19 pandemic: A comparison of Canadians with and without underlying health conditions.

Health Rep 2020 Jul;31(5):3-8

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: The risk of experiencing adverse outcomes from the coronavirus disease 2019 (COVID-19), such as hospitalization, admission to intensive care units and death, is elevated for older individuals and those with certain underlying health conditions including diabetes, chronic conditions affecting lungs, heart or kidneys, and a compromised immune system.

Data And Methods: Data collected between March 29 and April 3, 2020 from the Canadian Perspectives Survey Series 1: Impacts of COVID-19 (n=4,627) were used to estimate the prevalence of underlying health conditions, health concerns and precautionary behaviours among Canadians aged 15 or older living in the provinces. Multivariate analyses examined associations between these variables after accounting for age, sex and education. Read More

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http://dx.doi.org/10.25318/82-003-x202000500001-engDOI Listing

Understanding the Perceived Mental Health of Canadians During the COVID-19 Pandemic.

Health Rep 2020 Jun;31(4):22-27

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: While the physical health implications of the COVID-19 pandemic are regularly publicly available, the mental health toll on Canadians is unknown. This article examines the self-perceived mental health of Canadians during the COVID-19 pandemic and explores associations with various concerns after accounting for socioeconomic and health factors.

Data: The cross-sectional Canadian Perspectives Survey Series 1 collected information related to COVID-19 in late March and early April 2020 concerning labour market participation, behaviours, and health for the Canadian population 15 years and older living in the 10 provinces. Read More

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http://dx.doi.org/10.25318/82-003-x202000400003-engDOI Listing

Provincial variations in birth outcomes according to maternal country of birth, 2000 to 2016.

Health Rep 2020 Jun;31(4):13-21

Manitoba Centre for Health Policy, and the Community Health Sciences Department, University of Manitoba, Winnipeg, Manitoba.

Background: International migration is the main source of population growth in Canada. Research on the birth outcomes of immigrants has largely been based on Canadian provincial data, raising concerns about whether the findings can be generalized between provinces or between the provinces and Canada. Provincial time trends and variations in birth outcomes are described according to the 20 top maternal birthplaces. Read More

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http://dx.doi.org/10.25318/82-003-x202000400002-engDOI Listing

Change in vegetable and fruit consumption in Canada between 2004 and 2015.

Health Rep 2020 Jun;31(4):3-12

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: Eating plenty of vegetables and fruits on a daily basis is the foundation of a healthy diet. This study investigated patterns in Canadians' vegetable and fruit consumption in 2015 and compared these with 2004 data.

Data And Methods: The 2015 Canadian Community Health Survey (CCHS) - Nutrition and the 2004 CCHS - Nutrition (Cycle 2. Read More

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http://dx.doi.org/10.25318/82-003-x202000400001-engDOI Listing

Social isolation and mortality among Canadian seniors.

Health Rep 2020 Jun;31(3):27-38

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: Subjective and objective measures of isolation have been associated with increased risk of mortality in many studies, and some have found differential effects.

Data And Methods: Canadian Community Health Survey-Healthy Aging data (2008/2009) linked to the Canadian Vital Statistics-Death Database were used to estimate the prevalence of social isolation measured objectively (low social participation) and subjectively (feelings of loneliness and weak sense of community belonging). Associations with death during the 8 to 9 year follow-up period were examined with multivariate Cox proportional hazards models controlling for sociodemographic and health-related characteristics. Read More

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http://dx.doi.org/10.25318/82-003-x202000300003-engDOI Listing

Disease assimilation: The mortality impacts of fine particulate matter on immigrants to Canada.

Health Rep 2020 Jun;31(3):14-26

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia.

Background: Immigrants make up 20% of the Canadian population; however, little is known about the mortality impacts of fine particulate matter (PM) air pollution on immigrants compared with non-immigrants, or about how impacts may change with duration in Canada.

Data And Methods: This study used the 2001 Canadian Census Health and Environment Cohort, a longitudinal cohort of 3.5 million individuals, of which 764,000 were classified as immigrants (foreign-born). Read More

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http://dx.doi.org/10.25318/82-003-x202000300002-engDOI Listing

Accuracy of matching residential postal codes to census geography.

Health Rep 2020 Jun;31(3):3-13

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: Postal codes are often the only geographic identifier available to match subjects in a health dataset to census geography. This paper describes the characteristics of postal codes reported by the Canadian population on the census and, as an indicator of geocoding accuracy, the proportion that are linked to a single dissemination area (DA).

Data And Methods: Postal codes reported on the 2016 Census questionnaire were matched to a combination of the Postal Code Conversion File (PCCF) and the Postal Code Conversion File Plus (PCCF+ version 7B) (reference date November 2018) to calculate population-weighted counts and the number of matches to DAs by province or territory, delivery mode type (DMT), population centre or rural area size, and census metropolitan area. Read More

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http://dx.doi.org/10.25318/82-003-x202000300001-engDOI Listing

Acute care surgery, trauma and disaster relief: a clinical exchange between the University of British Columbia and the Mexican Red Cross.

Can J Surg 2020 Jul 9;63(4):E338-E345. Epub 2020 Jul 9.

From the Department of Surgery, University of British Columbia, Vancouver, B.C. (Margolick, Yin, Joharifard, Joos); the HCCR Polanco Cruz Roja, Mexico City, Mexico (Afya, Velez, Meza); the Canadian Red Cross, Ottawa, Ont. (Sohani); Trauma Services, Vancouver General Hospital, Vancouver, B.C. (Laane, Joos); the Branch for International Surgical Care, University of British Columbia, Vancouver, B.C. (Ball-Banting, Joos).

Background: Our objective was to establish a sustainable educational partnership and clinical exchange between the trauma services at Vancouver General Hospital (VGH) and the Mexican Red Cross hospital in Mexico City (Hospital Central de la Cruz Roja [HCCR] Polanco).

Methods: In 2017, a general surgery resident in postgraduate year 4 travelled from VGH to HCCR Polanco for the initial exchange, followed by a trauma fellow. The surgical case volumes in a month at VGH and a month at HCCR Polanco were compared. Read More

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http://dx.doi.org/10.1503/cjs.004719DOI Listing

Nursing handoffs and clinical judgments regarding patient risk of deterioration: A mixed-methods study.

J Clin Nurs 2020 Jul 9. Epub 2020 Jul 9.

Ingram School of Nursing, McGill University, Montreal, Canada.

Aims And Objectives: To explore how change-of-shift handoffs relate to nurses' clinical judgments regarding patient risk of deterioration.

Background: The transfer of responsibility for patients' care comes with an exchange of information about their condition during change-of-shift handoff. However, it is unclear how this exchange affects nurses' clinical judgments regarding patient risk of deterioration. Read More

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http://dx.doi.org/10.1111/jocn.15409DOI Listing

The Crying Clinic: Increasing accessibility to Infant Mental Health services for immigrant parents at risk for peripartum depression.

Infant Ment Health J 2020 Jul 9. Epub 2020 Jul 9.

Aisling Discoveries Child and Family Centre, Scarborough, Canada.

Peripartum depression (PPD) is considered a major public health concern due to its profound impact on families, including infants. In this paper, we report on a pilot initiative designed to reduce barriers and stigma related to the use of traditional infant mental health services for immigrant parents deemed at high risk of PPD. The Crying Clinic (CC) is an innovative walk-in service offered in a culturally diverse Canadian community to support maternal well-being and healthy parent-infant relationships. Read More

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http://dx.doi.org/10.1002/imhj.21879DOI Listing

The Connection Between Animal Abuse, Emotional Abuse, and Financial Abuse in Intimate Relationships: Evidence From a Nationally Representative Sample of the General Public.

J Interpers Violence 2020 Jul 9:886260520939197. Epub 2020 Jul 9.

University of Windsor, Ontario, Canada.

This article empirically examines the extent to which the co-occurrence of the maltreatment of companion animals and intimate partner violence (IPV) previously documented in samples of women accessing services from domestic violence shelters extends to a nationally representative sample of the general Canadian population, with a specific focus on emotional and financial abuse. Using data from the intimate partner victimization module of the 2014 Canadian General Social Survey ( = 17,950), the authors find that reporting one's intimate partner threatened or abused companion animals in the home increased the probability that one had experienced at least one form of emotional abuse or financial abuse by 38.6% ( ≤ . Read More

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http://dx.doi.org/10.1177/0886260520939197DOI Listing

Comorbid pain experiences in young women with dysmenorrhea.

Women Health 2020 Jul 8:1-12. Epub 2020 Jul 8.

Department of Psychology, University of Saskatchewan , Saskatoon, Saskatchewan, Canada.

The association among dysmenorrhea, chronic pain, and conditions classified as central sensitivity syndromes (CSS) is largely unknown. We investigated the co-occurrence of dysmenorrhea with chronic pain and other CSS (e.g. Read More

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http://dx.doi.org/10.1080/03630242.2020.1781741DOI Listing

"": a survey Ontario's school-based HPV immunization program ten years post-implementation.

Hum Vaccin Immunother 2020 Jul 9:1-6. Epub 2020 Jul 9.

Department of Clinical Public Health, Dalla Lana School of Public Health , Ontario, Canada.

Objectives: Describe Ontario's school-based human papillomavirus (HPV) vaccination program from the perspective of local public health units (PHUs).

Methods: In 2018, Vaccine Preventable Diseases (VPD) managers at each of Ontario's 35 PHUs were invited to participate in an online survey regarding the organization and delivery of their HPV vaccination program. Questions were asked on the school-based program, training and support of vaccine providers, communication and promotion, assessing coverage rates and perceptions of the program's strengths and challenges. Read More

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http://dx.doi.org/10.1080/21645515.2020.1775456DOI Listing

A Promoted Charge Separation/Transfer System from Cu Single Atoms and C N Layers for Efficient Photocatalysis.

Adv Mater 2020 Jul 9:e2003082. Epub 2020 Jul 9.

Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin, 150080, P. R. China.

Establishing highly effective charge transfer channels in carbon nitride (C N ) for enhancing its photocatalytic activity is still a challenging issue. Herein, for the first time, the engineering of C N layers with single-atom Cu bonded with compositional N (CuN ) is demonstrated to address this challenge. The CuN is formed by intercalation of chlorophyll sodium copper salt into a melamine-based supramolecular precursor followed by controlled pyrolysis. Read More

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http://dx.doi.org/10.1002/adma.202003082DOI Listing

The impact of high intensity care around birth on long-term neurodevelopmental outcomes.

Health Econ Rev 2020 Jul 8;10(1):22. Epub 2020 Jul 8.

Department of Pediatrics, Faculty of Medicine, McGill University, 3605 Rue de la Montagne, Montréal, QC, H3G 2M1, Canada.

Background: An equitable and affordable healthcare system requires a constant search for the optimal way to deliver increasingly expensive neonatal care. Therefore, evaluating the impact of hospital intensity around birth on long-term health outcomes is necessary if we are to assess the value of high intensity neonatal care against its costs.

Methods: This study exploits uneven geographical distribution of high intensity birth hospitals across Canada to generate comparisons across similar Cerebral Palsy (CP) related births treated at hospitals with different intensities. Read More

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http://dx.doi.org/10.1186/s13561-020-00279-8DOI Listing

Reconsidering as a proxy for zoonotic tuberculosis: a molecular epidemiological surveillance study.

Lancet Microbe 2020 Jun;1(2):e66-e73

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

Background: Zoonotic tuberculosis is defined as human infection with . Although globally, India has the largest number of human tuberculosis cases and the largest cattle population, in which bovine tuberculosis is endemic, the burden of zoonotic tuberculosis is unknown. The aim of this study was to obtain estimates of the human prevalence of animal-associated members of the complex (MTBC) at a large referral hospital in India. Read More

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http://dx.doi.org/10.1016/S2666-5247(20)30038-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325494PMC

Quality of life in patients with neurofibromatosis type 1 and 2 in Canada.

Neurooncol Adv 2020 Jul 10;2(Suppl 1):i141-i149. Epub 2020 Jan 10.

Division of Neurology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada.

Background: There is scarce data on the quality of life of people with neurofibromatosis type 1 (NF1) and type 2 (NF2) in Canada.

Methods: A cross-sectional study of adults with NF1 and NF2 attending a tertiary center. Patients completed generic measures (SF-36, EQ-5D-5L, and PROMIS pain interference) and disease-specific questionnaires (PedsQL NF1 module and the NFTI-QOL for NF2). Read More

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http://dx.doi.org/10.1093/noajnl/vdaa003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317053PMC

Publication Productivity Among Academic Orthopaedic Surgeons in Canada.

Cureus 2020 Jun 4;12(6):e8441. Epub 2020 Jun 4.

Division of Orthopaedic Surgery, Western University, London, CAN.

Objective The Hirsch Index (h-index) and m-index are often utilized to assess academic productivity and have been widely found to have a positive association with academic promotion and grant selection. The aim of this study was to assess the relationship between these indices and academic ranks among Canadian orthopaedic surgery faculty members. Methods Five hundred and sixty-seven Canadian orthopaedic surgery faculty members associated with residency training programs were included in the study. Read More

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http://dx.doi.org/10.7759/cureus.8441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336609PMC

Predicting the rate of oxygen consumption during the 3-minute constant-rate stair stepping and shuttle tests in people with chronic obstructive pulmonary disease.

J Thorac Dis 2020 May;12(5):2489-2498

Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, Canada.

Background: The 3-minute constant-rate stair stepping (3-min CRSST) and constant-speed shuttle tests (3-min CSST) were developed to assess breathlessness in response to a standardized exercise stimulus. Estimating the rate of oxygen consumption (V'O) during these tests would assist clinicians to relate the stepping/shuttle speeds that elicit breathlessness to daily physical activities with a similar metabolic demand. This study: (I) developed equations to estimate the V'O of these tests in people with chronic obstructive pulmonary disease (COPD); and (II) compared the newly developed and American College of Sports Medicine (ACSM) metabolic equations for estimating the V'O of these tests. Read More

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http://dx.doi.org/10.21037/jtd.2020.03.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330369PMC

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy.

Nat Commun 2020 Jul 8;11(1):3406. Epub 2020 Jul 8.

Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada.

Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is limited. To overcome these limitations, we performed single-cell RNA sequencing on 53586 adult glioblastoma cells and 22637 normal human fetal brain cells, and compared the lineage hierarchy of the developing human brain to the transcriptome of cancer cells. Read More

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http://dx.doi.org/10.1038/s41467-020-17186-5DOI Listing

The deleterious association between proton pump inhibitors and prostate cancer-specific mortality - a population-based cohort study.

Prostate Cancer Prostatic Dis 2020 Jul 8. Epub 2020 Jul 8.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada.

Background: Proton pump inhibitors (PPIs) are commonly prescribed medications that have been shown to have contradicting effects on cancer. We aimed to investigate the effect of pantoprazole and other PPIs on prostate cancer (PCa) specific mortality (PCSM), use of androgen deprivation therapy (ADT), and PCa diagnosis using a large Canadian population-based cohort.

Methods: We identified 21,512 men aged ≥ 66, with a history of a single negative prostate biopsy and no previous use of any of the analyzed medications between 1994 and 2016. Read More

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http://dx.doi.org/10.1038/s41391-020-0248-9DOI Listing

Universal Drug Coverage and Socioeconomic Disparities in Health Care Costs Among Persons With Diabetes.

Diabetes Care 2020 Jul 8. Epub 2020 Jul 8.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

Objective: To examine whether neighborhood socioeconomic status (SES) is a predictor of non-drug-related health care costs among Canadian adults with diabetes and, if so, whether SES disparities in costs are reduced after age 65 years, when universal drug coverage commences as an insurable benefit.

Research Design And Methods: Administrative health databases were used to examine publicly funded health care expenditures among 698,113 younger (20-64 years) and older (≥65 years) adults with diabetes in Ontario from April 2004 to March 2014. Generalized linear models were constructed to examine relative and absolute differences in health care costs (total and non-drug-related costs) across neighborhood SES quintiles, by age, with adjustment for differences in age, sex, diabetes duration, and comorbidity. Read More

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http://dx.doi.org/10.2337/dc19-1536DOI Listing

The clinical utility of routine spinal radiographs by chiropractors: a rapid review of the literature.

Chiropr Man Therap 2020 Jul 9;28(1):33. Epub 2020 Jul 9.

Faculty of Health Sciences, Ontario Tech University and Centre for Disability Prevention and Rehabilitation, 2000 Simcoe St N, Oshawa, ON, L1G 0C5, Canada.

Introduction: When indicated by signs or symptoms of potentially serious underlying pathology (red flags), chiropractors can use radiographs to inform their diagnosis. In the absence of red flags, the clinical utility of routine or repeat radiographs to assess the structure and function of the spine is controversial.

Objectives: To determine the diagnostic and therapeutic utility of routine or repeat radiographs (in the absence of red flags) of the cervical, thoracic or lumbar spine for the functional or structural evaluation of the spine. Read More

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http://dx.doi.org/10.1186/s12998-020-00323-8DOI Listing

One third of dementia cases can be prevented within the next 25 years by tackling risk factors. The case "for" and "against".

Alzheimers Res Ther 2020 Jul 8;12(1):81. Epub 2020 Jul 8.

Division of Psychiatry, University College London, London, UK.

Background: Recently, it has been suggested that up to a third of the dementia cases might be preventable. While prevention is always better than cure, this is particularly important in the field of dementia, as current interventions are not able to modify the disease. This article revises the evidence "for" and "against" dementia primary prevention. Read More

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http://dx.doi.org/10.1186/s13195-020-00646-xDOI Listing

Provincial Door-to-Needle Improvement Initiative Results in Improved Patient Outcomes Across an Entire Population.

Stroke 2020 Jul 9:STROKEAHA120029734. Epub 2020 Jul 9.

Department of Clinical Neurosciences, University of Calgary, Alberta, Canada. (N.K., E.E.S., A.M.D., M.D.H.).

Background And Purpose: Improving door-to-needle times (DNTs) for thrombolysis of acute ischemic stroke patients improves outcomes, but participation in DNT improvement initiatives has been mostly limited to larger, academic medical centers with an existing interest in stroke quality improvement. It is not known whether quality improvement initiatives can improve DNT at a population level, including smaller community hospitals. This study aims to determine the effect of a provincial improvement collaborative intervention on improvement of DNT and patient outcomes. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029734DOI Listing

Moving Toward a Standardized National Family Medicine Subinternship Curriculum: Results From a CERA Clerkship Directors Survey.

Fam Med 2020 Jun;52(7):523-527

Department of Family Medicine, Saint Louis University School of Medicine, St Louis, MO.

Background And Objectives: Although the subinternship (sub-I) is considered integral in many medical schools' curricula, family medicine does not have standardized course recommendations. Given the variable nature of this clinical experience, this study investigated the potential role of a standardized sub-I curriculum in family medicine.

Methods: Questions about sub-Is were created and data were gathered and analyzed as part of the 2019 Council of Academic Family Medicine's (CAFM) Educational Research Alliance (CERA) survey of family medicine clerkship directors. Read More

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http://dx.doi.org/10.22454/FamMed.2020.209444DOI Listing