120,596 results match your criteria Canadian Journal Of Information And Library Science-revue Canadienne Des Sciences De L Information Et De Bibliotheconomie[Journal]


The Montreal Cognitive Assessment After Omission of Hearing-Dependent Subtests: Psychometrics and Clinical Recommendations.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Department of Psychology, Concordia University, Montréal, Quebec, Canada.

Objectives: Hearing loss (HL) is the third most common chronic health condition in older adults, yet it is often undiagnosed and/or untreated. Given the association between HL and cognitive impairment, it is expected that many people undergoing cognitive screening may have HL. The Montreal Cognitive Assessment (MoCA) is a brief screening test that assesses a wide range of cognitive functions sensitive to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Read More

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http://dx.doi.org/10.1111/jgs.15940DOI Listing

Case-Completeness of Nonmalignant Central Nervous System Tumors in the Canadian Cancer Registry, 2011-2015.

J Registry Manag 2018 ;45(1):117-131

Introduction: The public health burden of nonmalignant central nervous system tumors (NMCNSTs) in Canada is unclear because casefinding and registration have historically been incomplete. The primary objective of this study is to quantify case-completeness of NMCNSTs in the Canadian Cancer Registry (CCR) using US Surveillance, Epidemiology and End Results Program (SEER) rates as the standard.

Methods: Counts, distributions, and age-standardized incidence rates (ASIRs) for malignant central nervous system tumors (MCNSTs) and NMCNSTs by sex, age, site, histology, tumor size, World Health Organization (WHO) grade, and year of diagnosis were estimated for the United States and Canada (excluding Quebec) for the time period 2011-2015 using SEER and CCR data, respectively. Read More

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January 2018

Canadian newcomer children's bone health and vitamin D status.

Appl Physiol Nutr Metab 2019 Apr 24:1-8. Epub 2019 Apr 24.

b College of Pharmacy and Nutrition, University of Saskatchewan, 104 Clinic Place, SK S7N 2Z4, Canada.

Adequate calcium intake and supply of vitamin D during childhood play important roles in ensuring adequate bone mass gain to achieve optimal peak bone mass. The Healthy Immigrant Children study employed a mixed-method cross-sectional study design to characterize the health and nutritional status of 300 immigrant and refugee children aged 3-13 years who had been in Canada for less than 5 years. This paper presents bone mineral content and vitamin D status data along with qualitative data that deepen the understanding of newcomer bone health status. Read More

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http://dx.doi.org/10.1139/apnm-2018-0705DOI Listing
April 2019
1 Read

Structural origin of the high-performance light-emitting InGaN/AlGaN quantum disks.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department of Materials Science and Engineering and Canadian Centre for Electron Microscopy, McMaster University, Main Street West, Hamilton, Ontario L8S 4M1, Canada.

Ternary III-nitride-based nanowires with highly efficient light-emitting properties are essential for a broad range of applications. By using the selective area molecular-beam epitaxy method, InGaN/AlGaN quantum disks (QDs) embedded in hexagonal GaN nanowires were successfully grown. With the help of atomic-scale-resolved transmission electron microscopy and atom probe tomography, atomic ordering and other related structural information, such as crystallography and local chemistry, have been unambiguously revealed to provide unique insights into the exceptionally strong photoluminescence enhancements. Read More

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http://dx.doi.org/10.1039/c9nr01262aDOI Listing

A Framework for Aiding the Translation of Scientific Evidence into Policy: The Experience of a Hospital-Based Technology Assessment Unit.

Int J Technol Assess Health Care 2019 Apr 24:1-8. Epub 2019 Apr 24.

Technology Assessment Unit,McGill University Health Centre,Montreal,Canada.

Objectives: Very few practical frameworks exist to guide the formulation of recommendations at hospital-based health technology assessment (HTA) units. The objectives of our study were: (i) to identify decision criteria specific to the context of hospital-based health technologies and interventions, (ii) to estimate the extent to which the expert community agrees on the importance of the identified criteria, (iii) to incorporate the identified criteria into a decision-aid tool, and (iv) to illustrate the application of a prototype decision-aid tool.

Methods: Relevant decision criteria were identified using existing frameworks for HTA recommendations, our past experience, a literature search, and feedback from a survey of diverse stakeholders. Read More

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http://dx.doi.org/10.1017/S0266462319000254DOI Listing

From the voices of people with haemophilia A and their caregivers: Challenges with current treatment, their impact on quality of life and desired improvements in future therapies.

Haemophilia 2019 Apr 23. Epub 2019 Apr 23.

Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Haemophilia A is a chronic disease requiring frequent intravenous infusions of recombinant factor VIII. Previous studies have shown that challenges associated with current treatments may have significant impacts on quality of life (QoL) that are as important as the health outcomes conferred by the therapy. Emerging therapeutic innovations offer the potential to mitigate treatment-related challenges, and it is therefore important to develop a better understanding of patient and caregiver experiences with existing haemophilia A treatments in order to characterize the full value of new treatments. Read More

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http://dx.doi.org/10.1111/hae.13754DOI Listing

Exposure to caring parenting and adult mental health in extremely low birthweight survivors.

J Paediatr Child Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Aim: Individuals born at extremely low birthweight (ELBW; <1000 g) are exposed to early adversities that increase the risk of mental health problems in later life. Caring parenting has been shown to offset the negative effects of early adversity in general population samples. However, the long-term impact of caring parenting on the mental health of preterm survivors in adulthood is not known. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.14476
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http://dx.doi.org/10.1111/jpc.14476DOI Listing
April 2019
1 Read

Visual and auditory perceptual strength norms for 3,596 French nouns and their relationship with other psycholinguistic variables.

Behav Res Methods 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychology, University of Montreal, Montreal, Quebec, Canada.

Perceptual experience plays a critical role in the conceptual representation of words. Higher levels of semantic variables such as imageability, concreteness, and sensory experience are generally associated with faster and more accurate word processing. Nevertheless, these variables tend to be assessed mostly on the basis of visual experience. Read More

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http://dx.doi.org/10.3758/s13428-019-01254-wDOI Listing

Adversity in childhood and depression in pregnancy.

Arch Womens Ment Health 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Nursing, University of Calgary, 2500 University Dr. N.W, Calgary, Alberta, T2N 1N4, Canada.

Adverse childhood experiences (ACEs) have been found to be associated with various health conditions; however, there is dearth of evidence on the relationship between ACEs and prenatal depression. This study was conducted to determine the association between overall ACE score and prenatal depression symptoms, assess the moderating effect of social support and partner support on this relationship, and determine the association between individual ACE scores and prenatal depression. A secondary analysis was conducted of data from an RCT that assessed the feasibility of e-screening for maternal mental health among 636 pregnant women recruited from antenatal clinics. Read More

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http://dx.doi.org/10.1007/s00737-019-00966-4DOI Listing

Work Disability Management Communication Bottlenecks Within Large and Complex Public Service Organizations: A Sociotechnical Systems Study.

J Occup Rehabil 2019 Apr 17. Epub 2019 Apr 17.

Institute for Work & Health, 481 University Avenue, Toronto, ON, M5G 2E9, Canada.

Purpose Within large and complex organizations work disability (WD) communication bottlenecks emerge and contribute to avoidable disability days. Our study utilized soft systems methods to better understand communication problems in WD management. Methods Semi-structured interviews were conducted with disability case managers (n = 10), frontline supervisors (n = 15) and human resource/labor relations specialists (n = 5) within three public service organizations. Read More

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http://dx.doi.org/10.1007/s10926-019-09836-3DOI Listing

DNAmod: the DNA modification database.

J Cheminform 2019 Apr 23;11(1):30. Epub 2019 Apr 23.

Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Research Tower 15-701, 101 College Street, Toronto, ON, M5G 1L7, Canada.

Covalent DNA modifications, such as 5-methylcytosine (5mC), are increasingly the focus of numerous research programs. In eukaryotes, both 5mC and 5-hydroxymethylcytosine (5hmC) are now recognized as stable epigenetic marks, with diverse functions. Bacteria, archaea, and viruses contain various other modified DNA nucleobases. Read More

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http://dx.doi.org/10.1186/s13321-019-0349-4DOI Listing

Novel Non-biologic Targets for Inflammatory Bowel Disease.

Curr Gastroenterol Rep 2019 Apr 23;21(5):22. Epub 2019 Apr 23.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA.

Purpose Of Review: The biologic era revolutionized the medical management of inflammatory bowel disease (IBD) and allowed for a paradigm shift away from a therapeutic strategy that traditionally relied on corticosteroids and immunomodulators. IBD treatment has now further evolved to encompass novel non-biologic agents.

Recent Findings: An electronic database search, spanning up to September 2018, was conducted using PubMed, Web of Science, Google Scholar, and Scopus. Read More

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http://link.springer.com/10.1007/s11894-019-0689-2
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http://dx.doi.org/10.1007/s11894-019-0689-2DOI Listing
April 2019
3 Reads

Tuberculosis in Canada: 2017.

Can Commun Dis Rep 2019 Feb 7;45(2-3):67-74. Epub 2019 Feb 7.

Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Background: Tuberculosis (TB) is a major global health problem that affected an estimated 10 million people worldwide in 2017. The Public Health Agency of Canada monitors active TB disease through a national surveillance system, which is a collaborative effort with the provinces and territories.

Objective: To present an epidemiological summary of active TB cases reported in 2017. Read More

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http://dx.doi.org/10.14745/ccdr.v45i23a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461129PMC
February 2019

The need for integrated public health surveillance to address sexually transmitted and blood-borne syndemics.

Can Commun Dis Rep 2019 Feb 7;45(2-3):63-66. Epub 2019 Feb 7.

School of Population and Public Health, University of British Columbia, Vancouver, BC.

A national approach to addressing sexually transmitted and blood-borne infections (STBBIs) was recently articulated in the Public Health Agency of Canada's new . This Framework promotes an integrated approach, with a focus on the key populations that are affected by overlapping epidemics (i.e. Read More

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http://dx.doi.org/10.14745/ccdr.v45i23a03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461126PMC
February 2019

Addressing the rising rates of gonorrhea and drug-resistant gonorrhea: There is no time like the present.

Can Commun Dis Rep 2019 Feb 7;45(2-3):54-62. Epub 2019 Feb 7.

Bacterial Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

Increasing rates of gonococcal (GC) infection and antimicrobial resistant (AMR) GC, are a serious public health concern for Canada and around the world. Previously recommended treatments are ineffective against many of the gonorrhea strains circulating today. The current recommendation for combination therapy is now being threatened by globally emerging and increasingly resistant strains. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v45i23a02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461120PMC
February 2019
1 Read

Multidrug-resistant and extensively drug-resistant in Canada, 2012-2016.

Can Commun Dis Rep 2019 Feb 7;45(2-3):45-53. Epub 2019 Feb 7.

Bacterial Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

Background: have acquired resistance to many antimicrobials, including third generation cephalosporins and azithromycin, which are the current gonococcal combination therapy recommended by the .

Objective: To describe antimicrobial susceptibilities for circulating in Canada between 2012 and 2016.

Methods: Antimicrobial resistance profiles were determined using agar dilution of isolated in Canada 2012-2016 (n=10,167) following Clinical Laboratory Standards Institute guidelines. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v45i23a01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461123PMC
February 2019
1 Read

Canadian Pandemic Influenza Preparedness: Antiviral strategy.

Authors:
B Henry

Can Commun Dis Rep 2019 Jan 3;45(1):38-43. Epub 2019 Jan 3.

Canadian Pandemic Influenza Preparedness Task Group, Chair.

Antiviral medications are the only influenza-specific pharmaceutical intervention that can be used to mitigate the impact of a pandemic until a vaccine becomes available. The (CPIP) outlines how federal, provincial and territorial governments will work together to ensure a coordinated and consistent health sector approach to pandemic influenza preparedness and response. This article summarizes Canada's pandemic influenza antiviral strategy as described in the recently updated CPIP Antiviral Annex. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v45i01a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461127PMC
January 2019
1 Read

Vaccine safety surveillance in Canada: Reports to CAEFISS, 2013-2016.

Can Commun Dis Rep 2018 Sep 6;44(9):206-214. Epub 2018 Sep 6.

CAEFISS: Canadian Adverse Events Following Immunization Surveillance System, Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Canada has one of the strongest vaccine safety surveillance systems in the world. This system includes both passive surveillance of all vaccines administered and active surveillance of all childhood vaccines.

Objectives: To provide 1) a descriptive analysis of the adverse events following immunization (AEFI) reports for vaccines administered in Canada, 2) an analysis of serious adverse events (SAEs) and 3) a list of the top ten groups of vaccines with the highest reporting rates. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449118PMC
September 2018

Clinical characteristics of pediatric pertussis cases, Quebec 2015-2017.

Can Commun Dis Rep 2018 Sep 6;44(9):190-195. Epub 2018 Sep 6.

Medical Microbiology and Infectious Diseases, Centre Hospitalier de l'Université de Montréal, Montréal, QC.

Background: The introduction of the acellular pertussis vaccine may have changed the epidemiological and clinical features of pertussis in Canadian children.

Objective: To describe the demographics, clinical presentation and outcomes of children and adolescents with pertussis presenting to a tertiary care hospital.

Methods: Retrospective cohort of consecutive patients evaluated at the Centre Hospitalier Universitaire Sainte-Justine (CHUSJ) and tested with a bacterial multiplex real-time polymerase chain reaction (PCR) for or between June 2015 and March 2017. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449091PMC
September 2018

Do health care providers trust product monograph information regarding use of vaccines in pregnancy? A qualitative study.

Can Commun Dis Rep 2018 Jun 7;44(6):134-138. Epub 2018 Jun 7.

Department of Pediatrics, Dalhousie University, Halifax, NS.

Background: Influenza immunization is recommended in pregnancy to prevent severe infections in pregnant women and newborns, yet vaccine uptake remains low. Studies suggest that cautionary language in vaccine product monographs regarding safety and use in pregnancy affects health care providers' perceptions of vaccine safety and how they counsel pregnant women.

Objective: To conduct a qualitative analysis of health care provider perceptions of the safety of inactivated influenza vaccines and their recommendations for use in pregnancy based on product monograph language statements. Read More

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A novel wireless brain stimulation device for long-term use in freely moving mice.

Sci Rep 2019 Apr 23;9(1):6444. Epub 2019 Apr 23.

Centre de Recherche du CHU de Québec (CHUQ), Axe Neurosciences, 2705, Boulevard Laurier, Québec, QC, Canada.

Deep brain stimulation (DBS) has been used in clinical settings for many years despite a paucity of knowledge related to the anatomical and functional substrates that lead to benefits and/or side-effects in various disease contexts. In order to maximize the potential of this approach in humans, a better understanding of its mechanisms of action is absolutely necessary. However, the existing micro-stimulators available for pre-clinical models, are limited by the lack of relevant small size devices. Read More

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http://dx.doi.org/10.1038/s41598-019-42910-7DOI Listing

The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance.

Sci Rep 2019 Apr 23;9(1):6348. Epub 2019 Apr 23.

Urologic Oncology Research Division, Research Institute of McGill University Health Centre, Montréal, H4A 3J1, Canada.

Radical cystectomy (RC) together with bilateral pelvic lymph node dissection remains the standard treatment for muscle invasive bladder cancer (MIBC). However, radiation-based treatments such as tri-modal therapy (TMT) involving maximally performed transurethral resection of bladder tumor (TURBT), radiotherapy (XRT), and a chemosensitizer represent an attractive, less invasive alternative. Nevertheless, 25-30% of MIBC patients will experience local recurrence after TMT and half will develop metastasis. Read More

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http://dx.doi.org/10.1038/s41598-019-42864-wDOI Listing
April 2019
1 Read

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice.

Sci Rep 2019 Apr 24;9(1):6514. Epub 2019 Apr 24.

Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines the effects of AhR activation on hepatic transcriptome and metabolome rhythmicity in male C57BL/6 mice orally gavaged with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4 days for 28 days. TCDD diminished the rhythmicity of several core clock regulators (e. Read More

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http://dx.doi.org/10.1038/s41598-019-42760-3DOI Listing

Enhanced early-life nutrition upregulates cholesterol biosynthetic gene expression and Sertoli cell maturation in testes of pre-pubertal Holstein bulls.

Sci Rep 2019 Apr 23;9(1):6448. Epub 2019 Apr 23.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.

Well-fed prepuberal Holstein bulls had larger testes, earlier puberty, higher LH, testosterone and IGF-1, earlier and more proliferating and differentiating Sertoli cells, and greater sperm production potential. The objective was to determine effects of pre-pubertal nutrition on mRNA expression of testicular genes. Holstein bull calves were fed high or low diets (20 or 12% crude protein, respectively and 71. Read More

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http://dx.doi.org/10.1038/s41598-019-42686-wDOI Listing
April 2019
1 Read

Porous metal-metalloporphyrin gel as catalytic binding pocket for highly efficient synergistic catalysis.

Nat Commun 2019 Apr 23;10(1):1913. Epub 2019 Apr 23.

Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL, 33620, USA.

Synergistic catalysis occurring in an enzyme pocket shows enhanced performance through supramolecular recognition and flexibility. This study presents an aerogel capable of similar function by fabricating a gel catalyst with hierarchical porosity. Here, the as-prepared Co-MMPG, a Co(II) metal-metalloporphyrin gel, maintains enough conformational flexibility and features a binding pocket formed from the co-facial arrangement of the porphyrin rings, as elucidated through the combined studies of solid-state NMR and X-ray absorption near-edge structure (XANES). Read More

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http://dx.doi.org/10.1038/s41467-019-09881-9DOI Listing

Measured Canadian oil sands CO emissions are higher than estimates made using internationally recommended methods.

Nat Commun 2019 Apr 23;10(1):1863. Epub 2019 Apr 23.

Climate Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, ON, M3H 5T4, Canada.

The oil and gas (O&G) sector represents a large source of greenhouse gas (GHG) emissions globally. However, estimates of O&G emissions rely upon bottom-up approaches, and are rarely evaluated through atmospheric measurements. Here, we use aircraft measurements over the Canadian oil sands (OS) to derive the first top-down, measurement-based determination of the their annual CO emissions and intensities. Read More

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http://dx.doi.org/10.1038/s41467-019-09714-9DOI Listing
April 2019
2 Reads

Canadian hospitals not doing enough to prevent opioid theft.

Authors:
Wendy Glauser

CMAJ 2019 Apr;191(16):E455-E456

Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.109-5739DOI Listing

Prevalence and correlates of selling illicit cannabis among people who use drugs in Vancouver, Canada: A ten-year prospective cohort study.

Int J Drug Policy 2019 Apr 20;69:16-23. Epub 2019 Apr 20.

British Columbia Centre on Substance Use, 1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; CIHR Canadian HIV Trials Network, 588-1081 Burrard Street, Vancouver, BC, V6B 3E6, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada. Electronic address:

Background: The illicit selling and use of cannabis is prevalent among marginalized people who use illicit drugs (PWUD). Given that participation in illicit drug markets has been previously associated with a range of health and social harms, we sought to examine the predictors of selling cannabis among PWUD in Vancouver, Canada, a setting with a de facto legalized cannabis market, on the eve of the planned implementation of legalized non-medical cannabis including measures to regulate the existing illicit market.

Methods: Multivariable generalized estimating equations (GEE) logistic regression was used to analyze longitudinal factors associated with selling illicit cannabis among three prospective cohorts of PWUD between September 2005 and May 2015. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.02.006DOI Listing

Echinococcus multilocularis in a wild free-living eastern chipmunk (Tamias striatus) in Southern Ontario: A case report and subsequent field study of wild small mammals.

Vet Parasitol Reg Stud Reports 2018 Aug 30;13:234-237. Epub 2018 Jun 30.

Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada; Canadian Wildlife Health Cooperative, Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address:

Southern Ontario has recently been identified as a risk area for Echinococcus multilocularis, based on surveys of foxes (Vulpes vulpes) and coyotes (Canis latrans) which act as definitive hosts of the parasite. In this manuscript, we describe the first detection of E. multilocularis in an eastern chipmunk (Tamias striatus) in North America. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.06.009DOI Listing

Dracunculus infections in domestic dogs and cats in North America; an under-recognized parasite?

Vet Parasitol Reg Stud Reports 2018 Aug 5;13:148-155. Epub 2018 Jun 5.

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, Wildlife Health Building, 589 D.W. Brooks Dr., Athens, GA 30602, USA; Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602, USA. Electronic address:

We reviewed 62 new cases and 18 published reports of Dracunculus infections in domestic dogs and cats to describe the epidemiology of this parasite in dogs and cats in North America. We collected host and parasite data when available, including age, sex, and breed of dog, nematode location in the host, and any clinical signs at presentation and/or description of the apparent lesion. For dogs, infections were noted in six of the AKC breed groups, but none was reported from the toy group or the miscellaneous breed class. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183002
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http://dx.doi.org/10.1016/j.vprsr.2018.05.005DOI Listing
August 2018
1 Read

HIV leadership programming attendance is associated with PrEP and PEP awareness among young, gay, bisexual, and other men who have sex with men in Vancouver, Canada.

BMC Public Health 2019 Apr 24;19(1):429. Epub 2019 Apr 24.

British Columbia Centre for Excellence in HIV/AIDS, 608-1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.

Background: Young gay, bisexual, and other men who have sex with men (YGBM) may have reduced engagement and knowledge of HIV care and biomedical HIV prevention strategies, such as pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), and Treatment as Prevention (TasP), compared with adult GBM. We sought to understand differences in HIV prevention awareness, health care access, and service utilization between youth (16-29 years) and adult (≥30 year) GBM, as well as factors associated with attendance in HIV leadership programming among YGBM living in the publicly funded PrEP setting of Vancouver, Canada.

Methods: Sexually-active GBM were recruited using respondent-driven sampling (RDS) from February 2012 to February 2015. Read More

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http://dx.doi.org/10.1186/s12889-019-6744-yDOI Listing

Advanced assessment of migration and invasion of cancer cells in response to mifepristone therapy using double fluorescence cytochemical labeling.

BMC Cancer 2019 Apr 24;19(1):376. Epub 2019 Apr 24.

Experimental Pathology Unit, Department of Pathology, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Qc, H3A 2B4, Canada.

Background: Previous work in our laboratory demonstrated that antiprogestin mifepristone impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in their cellular morphology. In this study, we further assess the anti-metastatic properties of mifepristone, by studying whether cytostatic doses of the drug can inhibit the migration and invasion of various cancer cell lines using a double fluorescence cytochemical labeling approach.

Methods: Cell lines representing cancers of the ovary (SKOV-3), breast (MDA-MB-231), glia (U87MG), or prostate (LNCaP) were treated with cytostatic concentrations of mifepristone. Read More

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http://dx.doi.org/10.1186/s12885-019-5587-3DOI Listing

Reliability of routinely collected anthropometric measurements in primary care.

BMC Med Res Methodol 2019 Apr 24;19(1):84. Epub 2019 Apr 24.

Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Background: Measuring body mass index (BMI) has been proposed as a method of screening for preventive primary care and population surveillance of childhood obesity. However, the accuracy of routinely collected measurements has been questioned. The purpose of this study was to assess the reliability of height, length and weight measurements collected during well-child visits in primary care relative to trained research personnel. Read More

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http://dx.doi.org/10.1186/s12874-019-0726-8DOI Listing

A GaN-Based Wireless Monitoring System for High-Temperature Applications.

Sensors (Basel) 2019 Apr 14;19(8). Epub 2019 Apr 14.

Department of Electrical Engineering, Polytechnique Montreal, QC H3T 1J4, Canada.

A fully-integrated data transmission system based on gallium nitride (GaN) high-electron-mobility transistor (HEMT) devices is proposed. This system targets high-temperature (HT) applications, especially those involving pressure and temperature sensors for aerospace in which the environmental temperature exceeds 350 °C. The presented system includes a front-end amplifying the sensed signal (gain of 50 V/V), followed by a novel analog-to-digital converter driving a modulator exploiting the load-shift keying technique. Read More

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http://dx.doi.org/10.3390/s19081785DOI Listing

CFM-ID 3.0: Significantly Improved ESI-MS/MS Prediction and Compound Identification.

Metabolites 2019 Apr 13;9(4). Epub 2019 Apr 13.

Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.

Metabolite identification for untargeted metabolomics is often hampered by the lack of experimentally collected reference spectra from tandem mass spectrometry (MS/MS). To circumvent this problem, Competitive Fragmentation Modeling-ID (CFM-ID) was developed to accurately predict electrospray ionization-MS/MS (ESI-MS/MS) spectra from chemical structures and to aid in compound identification via MS/MS spectral matching. While earlier versions of CFM-ID performed very well, CFM-ID's performance for predicting the MS/MS spectra of certain classes of compounds, including many lipids, was quite poor. Read More

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http://dx.doi.org/10.3390/metabo9040072DOI Listing

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation.

Pharmaceutics 2019 Apr 12;11(4). Epub 2019 Apr 12.

School of Pharmacy, University of Waterloo, Kitchener, ON N2G 1C5, Canada.

Gold nanoparticles (AuNPs) are a focus of growing medical research applications due to their unique chemical, electrical and optical properties. Because of uncertain toxicity, "green" synthesis methods are emerging, using plant extracts to improve biological and environmental compatibility. Here we explore the biodistribution of green AuNPs in mice and prepare a physiologically-based pharmacokinetic (PBPK) model to guide interspecies extrapolation. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040179DOI Listing

miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation.

Int J Mol Sci 2019 Apr 12;20(8). Epub 2019 Apr 12.

Department of Biology, York University, Toronto, ON M3J 1P3, Canada.

Ovarian cancer is the leading cause of death from gynecological cancers. MicroRNAs (miRNAs) are small, non-coding RNAs that interact with the 3' untranslated region (3' UTR) of target genes to repress their expression. We have previously reported that miR-590-3p promoted ovarian cancer growth and metastasis, in part by targeting Forkhead box A (FOXA2). Read More

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http://dx.doi.org/10.3390/ijms20081810DOI Listing

The Spectrum of Interactions between and Bacteria.

J Fungi (Basel) 2019 Apr 12;5(2). Epub 2019 Apr 12.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

is a major fungal pathogen that infects immunocompromised people and causes life-threatening meningoencephalitis. does not occur in isolation either in the environment or in the human host, but is surrounded by other microorganisms. Bacteria are ubiquitously distributed in nature, including soil, and make up the dominant part of the human microbiota. Read More

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http://dx.doi.org/10.3390/jof5020031DOI Listing

Healthcare and End-of-Life Needs of Lesbian, Gay, Bisexual, and Transgender (LGBT) Older Adults: A Scoping Review.

Geriatrics (Basel) 2017 Mar 16;2(1). Epub 2017 Mar 16.

School of Social Work, Lakehead University, Thunder Bay, ON, P7B 5E1, Canada.

Lesbian, gay, bisexual, and transgender (LGBT) older adults face a number of challenges with respect to access to healthcare especially towards end-of-life. Through a systematic search and scoping review of the literature, we sought to answer two related research questions. In particular, the purpose of this scoping review was to determine the healthcare needs of LGBT older adults nearing end-of-life as well as the factors that contribute to a good death experience among older adults who identify as LGBT. Read More

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http://dx.doi.org/10.3390/geriatrics2010013DOI Listing

Sweat Loss and Hydration Habits of Female Olympic, Varsity and Recreational Ice Hockey Players.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada.

This study measured sweat losses, voluntary fluid intake, sodium balance, and carbohydrate intake of female ice hockey players during on-ice practices at the Olympic, varsity, and recreational levels. Testing was conducted on 25 Canadian Olympic players, 21 varsity, and 21 recreational players. The average sweat rate for the Olympic players (0. Read More

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http://dx.doi.org/10.1055/a-0877-7028DOI Listing

Media portrayal of illness-related medical crowdfunding: A content analysis of newspaper articles in the United States and Canada.

PLoS One 2019 23;14(4):e0215805. Epub 2019 Apr 23.

Health Law Institute, Faculty of Law, University of Alberta, Edmonton, Alberta, Canada.

Background: Medical crowdfunding is a growing phenomenon, and newspapers are publishing on the topic. This research analyzed how illness-related crowdfunding and crowdfunding campaigns have recently been represented in newspapers that are popular in the United States and Canada.

Methods: A sample of 336 articles about medical crowdfunding published during the two year time period from October 7, 2015 to October 6, 2017 was produced using a Factiva search of the English language newspapers with the largest Canadian and United States readership. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215805PLOS

Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Background: Sepsis is a complex clinical syndrome with substantial heterogeneity. We sought to identify patterns of serum biomarkers of endothelial activation and dysfunction in individuals with sepsis and evaluate subgroup-specific differences in mortality.

Methods: Adult patients with sepsis (n=426) were consecutively recruited from two hospitals in Uganda. Read More

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http://dx.doi.org/10.1172/jci.insight.127623DOI Listing

Nanowire Superinductance Fluxonium Qubit.

Phys Rev Lett 2019 Jan;122(1):010504

Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA.

We characterize a fluxonium qubit consisting of a Josephson junction inductively shunted with a NbTiN nanowire superinductance. We explain the measured energy spectrum by means of a multimode theory accounting for the distributed nature of the superinductance and the effect of the circuit nonlinearity to all orders in the Josephson potential. Using multiphoton Raman spectroscopy, we address multiple fluxonium transitions, observe multilevel Autler-Townes splitting and measure an excited state lifetime of T_{1}=20  μs. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.010504DOI Listing
January 2019

Intraluminal prucalopride increases propulsive motor activities via luminal 5-HT receptors in the rabbit colon.

Neurogastroenterol Motil 2019 Apr 23:e13598. Epub 2019 Apr 23.

Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

Background: Activating luminal 5-HT receptors results in the release of 5-HT from enterochromaffin cells into the lamina propria to modulate colonic motility. Our aim was to evaluate characteristics of colonic motor patterns involved in the prokinetic effects of intraluminal prucalopride in the rabbit colon.

Methods: Colonic motor patterns were studied ex vivo using simultaneous spatiotemporal diameter mapping and pressure sensing. Read More

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http://dx.doi.org/10.1111/nmo.13598DOI Listing

Taxonomy, together with ontogeny and growing conditions, drives needleleaf species' sensitivity to climate in boreal North America.

Glob Chang Biol 2019 Apr 23. Epub 2019 Apr 23.

Centre d'étude de la forêt, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montréal, QC, H3C 3P8, Canada.

Currently, there is no consensus regarding the way that changes in climate will affect boreal forest growth, where warming is occurring faster than in other biomes. Some studies suggest negative effects due to drought-induced stresses, while others provide evidence of increased growth rates due to a longer growing season. Studies focusing upon the effects of environmental conditions on growth-climate relationships are usually limited to small sampling areas that do not encompass the full range of environmental conditions; therefore, they only provide a limited understanding of the processes at play. Read More

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http://dx.doi.org/10.1111/gcb.14665DOI Listing

Frameworks for supporting patient and public involvement in research: Systematic review and co-design pilot.

Health Expect 2019 Apr 22. Epub 2019 Apr 22.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Numerous frameworks for supporting, evaluating and reporting patient and public involvement in research exist. The literature is diverse and theoretically heterogeneous.

Objectives: To identify and synthesize published frameworks, consider whether and how these have been used, and apply design principles to improve usability. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hex.12888
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http://dx.doi.org/10.1111/hex.12888DOI Listing
April 2019
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