602 results match your criteria Canadian Journal Of Gastroenterology And Hepatology[Journal]


Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis.

Can J Gastroenterol Hepatol 2020 13;2020:9327868. Epub 2020 Jan 13.

Department of Gastric Surgery, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning 110042, China.

Objective: Primary duodenum lymphoma (PDL) is extremely rare with limited data available in the literature. In this study, we sought to describe clinical features and identify factors affecting survival in patients with PDL using a large population cohort.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried from 1998 to 2015. Read More

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http://dx.doi.org/10.1155/2020/9327868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201497PMC
January 2020

Effectiveness of Conservative Treatment without Early Colonoscopy in Patients with Colonic Diverticular Hemorrhage.

Can J Gastroenterol Hepatol 2020 14;2020:3283940. Epub 2020 Jan 14.

Department of Digestive Internal Medicine, Saitama Red Cross Hospital, Saitama, Japan.

Aim: This study was aimed to clarify the effectiveness of conservative treatment without performing early colonoscopy and the indications for early colonoscopy in patients with colonic diverticular hemorrhage.

Methods: This retrospective study included 142 participants who were urgently hospitalized due to bloody stools and were diagnosed with colonic diverticular hemorrhage between April 2012 and December 2016. At the time of hospital visit, only when both shock based on vital signs and intestinal extravasation on abdominal contrast-enhanced computed tomography were observed, early colonoscopy was performed within 24 hours after hospitalization. Read More

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http://dx.doi.org/10.1155/2020/3283940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201635PMC
January 2020

Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study.

Can J Gastroenterol Hepatol 2020 14;2020:8219536. Epub 2020 Apr 14.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Background: Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort.

Methods: Blood samples obtained from 78,484 surgical patients from 18 different city and county hospitals were enrolled. Read More

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http://dx.doi.org/10.1155/2020/8219536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180502PMC

Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease.

Can J Gastroenterol Hepatol 2020 25;2020:2104314. Epub 2020 Apr 25.

Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

. Transforming growth factor-beta (TGF-) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD). Read More

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http://dx.doi.org/10.1155/2020/2104314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196971PMC

Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery.

Can J Gastroenterol Hepatol 2020 13;2020:7028216. Epub 2020 Apr 13.

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Background: The aim of this study was to investigate albumin, nutritional status, and inflammation in the perioperative course of patients undergoing elective intestinal surgery.

Methods: A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. Preoperatively, the correlation of albumin levels with markers for inflammation and nutritional status was investigated. Read More

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http://dx.doi.org/10.1155/2020/7028216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174932PMC

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats.

Can J Gastroenterol Hepatol 2020 17;2020:7920715. Epub 2020 Mar 17.

The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, College of Acupuncture & Moxibustion and Tui-na, Hunan University of Chinese Medicine, Changsha 410000, China.

Background: The incidence of diabetic gastroparesis (DGP) is mainly blamed to abnormity of interstitial cells of Cajal (ICCs). Autophagy could degrade damaged proteins and organelles to keep intracellular homeostasis, and it could directly influence structure and number of cells. In this study, we aimed to figure out the relationship between DGP and autophagy of ICCs. Read More

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http://dx.doi.org/10.1155/2020/7920715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060882PMC

Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department.

Can J Gastroenterol Hepatol 2020 17;2020:5258289. Epub 2020 Feb 17.

Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Approximately 0.7% of the Canadian population is infected with hepatitis C virus (HCV), and many individuals are unaware of their infection. Our objectives were to utilize an emergency department (ED) based point-of-care (POC) HCV screening test to describe our local population and estimate the proportion of high-risk patients in our population with undiagnosed HCV. Read More

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http://dx.doi.org/10.1155/2020/5258289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049435PMC
February 2020

Adherence to Azathioprine/6-Mercaptopurine in Children and Adolescents with Inflammatory Bowel Diseases: A Multimethod Study.

Can J Gastroenterol Hepatol 2020 25;2020:9562192. Epub 2020 Feb 25.

Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.

Background: Measurement of the degree of adherence is a key element for the evaluation of treatment efficacy and safety; thus, adherence plays an important role in clinical research and practice. The aim of this study was to investigate medication adherence in children with inflammatory bowel disease (IBD) utilizing a multimethod assessment approach. A further aim was to examine factors that can influence adherence within this population. Read More

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http://dx.doi.org/10.1155/2020/9562192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060881PMC
February 2020

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review.

Can J Gastroenterol Hepatol 2020 21;2020:3578927. Epub 2020 Feb 21.

Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, China.

Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Read More

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http://dx.doi.org/10.1155/2020/3578927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054765PMC
February 2020

A Potential Linking between Vitamin D and Adipose Metabolic Disorders.

Can J Gastroenterol Hepatol 2020 18;2020:2656321. Epub 2020 Feb 18.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Vitamin D has been discovered centuries ago, and current studies have focused on the biological effects of vitamin D on adipogenesis. Besides its role in calcium homeostasis and energy metabolism, vitamin D is also involved in the regulation of development and process of metabolic disorders. Adipose tissue is a major storage depot of vitamin D. Read More

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http://dx.doi.org/10.1155/2020/2656321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049848PMC
February 2020

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model.

Can J Gastroenterol Hepatol 2020 20;2020:2475301. Epub 2020 Feb 20.

Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa.

Background: Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. Read More

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http://dx.doi.org/10.1155/2020/2475301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053450PMC
February 2020

Comparison of the Effects of TIPS versus BRTO on Bleeding Gastric Varices: A Meta-Analysis.

Can J Gastroenterol Hepatol 2020 11;2020:5143013. Epub 2020 Feb 11.

Radiology Intervention Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

. Upper gastrointestinal bleeding is a threat to patients with gastric varices (GVs). Previous studies have concluded that both transjugular intrahepatic portosystemic shunt (TIPS) and balloon-occluded retrograde transvenous obliteration (BRTO) are effective treatments for patients with GV. Read More

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http://dx.doi.org/10.1155/2020/5143013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036113PMC
February 2020

Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir.

Can J Gastroenterol Hepatol 2020 27;2020:1632959. Epub 2020 Jan 27.

Tropical Medicine Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt.

Background: Direct-acting antivirals (DAAs) made a drastic change in the management of HCV infection. Sofosbuvir is one of the highly potent DAAs, eliminated mainly through the kidney. But concerns about renal safety during treatment may limit its use. Read More

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http://dx.doi.org/10.1155/2020/1632959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007947PMC
January 2020

Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach.

Can J Gastroenterol Hepatol 2020 21;2020:9181368. Epub 2020 Jan 21.

UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.

Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20-30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant association has been demonstrated between the inflammatory component of NAFLD, i. Read More

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http://dx.doi.org/10.1155/2020/9181368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995480PMC
January 2020

Intestinal Microbiome Changes in Fecal Microbiota Transplant (FMT) FMT Enriched with in the Treatment of Recurrent Infection.

Can J Gastroenterol Hepatol 2019 28;2019:4549298. Epub 2019 Dec 28.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, Mexico.

Aim: In this study, we conducted a comparative study to explore the differences in therapeutic efficacy and intestinal microbiome of fecal microbiota transplant (FMT) FMT in addition with (FMT-L) for treatment of recurrent infection (R-CDI).

Methods: We designed a double-blinded randomized comparative two-arm pilot multicenter study to assess the efficacy and impact in the intestinal microbiome of standard capsules of FMT FMT-L enriched with 3 species of for patients with R-CDI. A 90-day follow-up of 21 patients was performed, starting at the beginning of the study. Read More

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http://dx.doi.org/10.1155/2019/4549298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955117PMC
December 2019

Deficiency of Dietary Fiber in -Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu.

Can J Gastroenterol Hepatol 2019 27;2019:2543082. Epub 2019 Dec 27.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota. Various factors alter the gut microbiota which lead to dysbiosis; in particular, diet and dietary fibers constitute important determinants. Dietary fiber protects against IBD; bacteria ferment these dietary fibers in colon and generate short-chain fatty acids (SCFAs), which mediate the anti-inflammatory actions of dietary fibers. Read More

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http://dx.doi.org/10.1155/2019/2543082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949682PMC
December 2019

Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals.

Can J Gastroenterol Hepatol 2019 19;2019:8748459. Epub 2019 Dec 19.

Medical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.

Purpose: Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person's risk of NAFLD. Read More

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http://dx.doi.org/10.1155/2019/8748459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942793PMC
December 2019

Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.

Can J Gastroenterol Hepatol 2019 17;2019:6391712. Epub 2019 Dec 17.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Aim: Immune checkpoint inhibitors (ICIs) have improved the survival rate of patients carrying various malignant neoplasms. Despite their efficacy, ICIs occasionally induce liver injury as an immune-related adverse event (irAE). This study aimed to reveal the clinical features of the hepatic irAE in Japanese patients. Read More

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http://dx.doi.org/10.1155/2019/6391712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935806PMC
December 2019

A Randomized Placebo-Controlled -of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.

Can J Gastroenterol Hepatol 2019 12;2019:3926051. Epub 2019 Dec 12.

Head of Subdirección de Estudios Clínicos y Epidemiología Clínica (SECEC), Fundación Santa Fe de Bogotá, Bogotá, Colombia.

Background: Gastroesophageal reflux disease (GERD) is the most frequent chronic gastrointestinal disorder. It is defined as a condition developed when the reflux of gastric contents causes troublesome symptoms (heartburn and regurgitation). This requires adequate treatment since it can lead to long-term complications including esophagus adenocarcinoma. Read More

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http://dx.doi.org/10.1155/2019/3926051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935808PMC
December 2019

In Vivo Evaluation of Histopathological Alterations and Trace Metals Estimation of the Small Intestine in Bisphenol A-Intoxicated Rats.

Can J Gastroenterol Hepatol 2019 9;2019:9292316. Epub 2019 Dec 9.

Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore, Pakistan.

BPA, a ubiquitously used plasticizer, has become one of the contaminants of emerging concern and causes many serious health implications in humans due to multiple exposure pathways. The current study was aimed at investigating the deformities of structures that arise by exposure of the small intestine to BPA through trace elements estimation of tissues as well as the study of serum profile. Two major groups of Wistar rats were established: one control group and the other experimental group, which was further divided into four groups based on dose (10 mg/kg/bodyweight and 25 mg/kg/bodyweight, respectively) and duration of exposure (6 and 12 weeks, respectively). Read More

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http://dx.doi.org/10.1155/2019/9292316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925935PMC
December 2019

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis.

Can J Gastroenterol Hepatol 2019 22;2019:5236149. Epub 2019 Nov 22.

Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guiyang, Guizhou 550004, China.

Objective: Recently, blueberry has been identified as a candidate for the treatment of liver fibrosis. Given the role of gut-liver axis in liver fibrosis and the importance of the gut microbiota homeostasis to the maintenance of the intestinal epithelial barrier, this study aimed to investigate whether blueberry could attenuate liver fibrosis and protect the intestinal epithelial barrier by maintaining the homeostasis of the gut microbiota.

Method: A CCl-induced rat liver fibrosis model was used to detect the roles of blueberry in liver fibrosis and intestinal epithelial barrier. Read More

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http://dx.doi.org/10.1155/2019/5236149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893245PMC
November 2019

Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases.

Can J Gastroenterol Hepatol 2019 10;2019:1085717. Epub 2019 Dec 10.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

ATP-binding cassette (ABC) transporters are the members of the efflux pumps that are responsible for the removal of cytotoxic substances by active transport. ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane. Loss of functional ABCB11 and ABCB4 proteins causes early-onset refractory cholestasis or cholangiopathy. Read More

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http://dx.doi.org/10.1155/2019/1085717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925824PMC
December 2019

Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups.

Can J Gastroenterol Hepatol 2019 23;2019:2763093. Epub 2019 Nov 23.

Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: The present study aimed to explore the association between SUA and NAFLD in women with different menstrual statuses.

Methods: A total of 6043 women were selected from the Jidong and Kailuan communities for inclusion in the present study. The SUA levels of participants were divided into quartiles. Read More

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http://dx.doi.org/10.1155/2019/2763093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906828PMC
November 2019

Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53.

Can J Gastroenterol Hepatol 2019 2;2019:1389653. Epub 2019 Dec 2.

Laboratory of Hepatobiliary Molecular Oncology, Department of Hepatopancreatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410011, Hunan Province, China.

Background: Long noncoding RNAs (lncRNAs) have been known to play important roles in the progression of various types of human cancer. LncRNA GATA3 antisense RNA 1, GATA3-AS1, has been reported to be associated with T-cell development and differentiation. However, the expression pattern and function of GATA3-AS1 in hepatocellular carcinoma (HCC) remain unknown. Read More

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http://dx.doi.org/10.1155/2019/1389653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913283PMC
December 2019

A Prospective, Randomized Comparison of Duodenoscope Reprocessing Surveillance Methods.

Can J Gastroenterol Hepatol 2019 18;2019:1959141. Epub 2019 Nov 18.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison 53705, WI, USA.

Duodenoscope use in healthcare facilities has been associated with transmission of multidrug resistant pathogens between patients. To assist healthcare facilities in monitoring the quality of their duodenoscope reprocessing procedures and limit patient risk of infection, the Centers for Disease Control and Prevention (CDC) deployed voluntary interim duodenoscope sampling and culturing surveillance protocols in 2015. Though the interim methods were widely adopted, alternative surveillance protocols were developed and implemented at individual institutions. Read More

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http://dx.doi.org/10.1155/2019/1959141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885784PMC
November 2019

Simple Bedside Predictors of Survival after Percutaneous Gastrostomy Tube Insertion.

Can J Gastroenterol Hepatol 2019 16;2019:1532918. Epub 2019 Nov 16.

Department of Gastroenterology, Galilee Medical Center, Nahariya, Israel.

Background: Percutaneous endoscopic gastrostomy (PEG) tube insertion is an increasingly used minimally invasive method for long-term enteral feeding. Identification of simple predictors for short-term mortality (up to one month) after PEG insertion is of paramount importance.

Aim: We aimed to explore a simple noninvasive parameter that would predict survival following PEG insertion. Read More

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http://dx.doi.org/10.1155/2019/1532918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881763PMC
November 2019

As Clinical Markers, Hand-Foot-Skin Reaction and Diarrhea Can Predict Better Outcomes for Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization plus Sorafenib.

Can J Gastroenterol Hepatol 2019 14;2019:2576349. Epub 2019 Nov 14.

Department of Liver Disease and Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.

Background: Combination therapy of transarterial chemoembolization plus sorafenib (TACE-S) has been proven to be safe and effective for hepatocellular carcinoma (HCC); however, this combination therapy is associated with a high incidence of adverse events (AEs). Our study focused on the relationships between AEs and treatment outcomes and aimed to discover AE-based clinical markers that can predict the survival benefits of combination treatment.

Methods: From January 2010 to June 2014, a total of 235 HCC patients treated with TACE-S were retrospectively enrolled. Read More

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http://dx.doi.org/10.1155/2019/2576349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877904PMC
November 2019

Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival.

Can J Gastroenterol Hepatol 2019 27;2019:9691067. Epub 2019 Oct 27.

Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Purpose: To investigate whether lymphocyte nadir induced by radiation is associated with survival and explore its underlying risk factors in patients with hepatocellular carcinoma (HCC).

Methods: Total lymphocyte counts were collected from 184 HCC patients treated by radiotherapy (RT) with complete follow-up. Associations between gross tumor volumes (GTVs) and radiation-associated parameters with lymphocyte nadir were evaluated by Pearson/Spearman correlation analysis and multiple linear regression. Read More

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http://dx.doi.org/10.1155/2019/9691067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855067PMC
October 2019

The Impact of Revascularisation on Quality of Life in Chronic Mesenteric Ischemia.

Can J Gastroenterol Hepatol 2019 12;2019:7346013. Epub 2019 Nov 12.

Medisch Spectrum Twente (t.n.v. R.H. Geelkerken, Backoffice Chirurgie B11), Postbus 50.000, 7500 KA, Enschede, Netherlands.

Background: Chronic mesenteric ischemia (CMI) is characterized by long-standing abdominal symptoms due to insufficient mesenteric circulation. Data on the effect of revascularisation on quality of life (QoL) for CMI are scarce. This study is the first to evaluate the impact of revascularisation on quality of life. Read More

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http://dx.doi.org/10.1155/2019/7346013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874997PMC
November 2019

Plasma -Glutathione -Transferase Evaluation in Patients with Acute and Chronic Liver Injury.

Can J Gastroenterol Hepatol 2019 20;2019:5850787. Epub 2019 Oct 20.

Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 24 Karłowicza St, 85-092 Bydgoszcz, Poland.

High concentration of alpha-glutathione -transferase (-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of -GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. Read More

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http://dx.doi.org/10.1155/2019/5850787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854929PMC
October 2019

Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.

Can J Gastroenterol Hepatol 2019 20;2019:3585136. Epub 2019 Oct 20.

Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Esophageal candidiasis (EC) is the most common type of infectious esophagitis. In the gastrointestinal tract, the esophagus is the second most susceptible to candida infection, only after the oropharynx. Immunocompromised patients are most at risk, including patients with HIV/AIDS, leukemia, diabetics, and those who are receiving corticosteroids, radiation, and chemotherapy. Read More

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http://dx.doi.org/10.1155/2019/3585136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854261PMC
October 2019

Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease.

Can J Gastroenterol Hepatol 2019 15;2019:6028952. Epub 2019 Oct 15.

Department of Infectious Diseases, First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

Objective: We aimed at analyzing the role of smoking in hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and at exploring the related risk factors.

Methods: This was a cross-sectional study that included a total of 225 patients with NAFLD. Among them, 127 were nonsmokers and 98 were smokers. Read More

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http://dx.doi.org/10.1155/2019/6028952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815556PMC
October 2019
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The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study.

Can J Gastroenterol Hepatol 2019 7;2019:5121574. Epub 2019 Oct 7.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Background: The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD. Read More

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http://dx.doi.org/10.1155/2019/5121574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800935PMC
October 2019
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Renal Dysfunction is a Risk Factor of Death after Gastric Endoscopic Submucosal Dissection in Elderly Patients Aged ≥80 Years.

Can J Gastroenterol Hepatol 2019 9;2019:7145182. Epub 2019 Sep 9.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Introduction: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is well accepted. However, its adaptation for elderly patients is unclear. This study aimed to investigate the prognosis and long-term outcomes of ESD for EGC in elderly patients aged ≥80 years by comparing their findings to the findings of patients aged <80 years. Read More

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http://dx.doi.org/10.1155/2019/7145182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754868PMC
September 2019
2 Reads

Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

Can J Gastroenterol Hepatol 2019 20;2019:2096161. Epub 2019 Aug 20.

Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.

Background And Aims: Recent studies have indicated that circulating miRNAs could serve as accurate biomarkers for diagnosing nonalcoholic fatty liver disease (NAFLD). We aimed to assess the evidence on the probability of circulating miRNAs as new diagnostic biomarkers in patients with NAFLD.

Methods: We comprehensively retrieved relevant English literature from the databases of PubMed, Embase, and the Cochrane Library from 2000 to 1 January 2019. Read More

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http://dx.doi.org/10.1155/2019/2096161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720843PMC

Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study.

Can J Gastroenterol Hepatol 2019 9;2019:9046260. Epub 2019 Jul 9.

Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, Nantong 226006, China.

Purpose: To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy.

Methods: A total of 651 pregnant women aged 18-40 in Nantong Third People's Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥10 copies/mL (n=251) received LdT during late pregnancy according to the patients' will, while 136 high viral patients with HBV DNA≥10 copies/mL who did not take LdT therapy and 268 low viral patients with HBV DNA<10 copies/mL served as the controls. Read More

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http://dx.doi.org/10.1155/2019/9046260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652084PMC
July 2019
2 Reads

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study.

Authors:
Oumer Abdu Muhie

Can J Gastroenterol Hepatol 2019 8;2019:5958032. Epub 2019 Jul 8.

Department of Internal Medicine, CMHS, University of Gondar, P.O. Box 196, Ethiopia.

Background: Ascites is a common clinical condition encountered by physicians in day-to-day practice. It is caused by various underlying diseases. Knowing the etiologies is vital because further investigations and definitive treatment largely rely on the specific disease entity considered. Read More

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http://dx.doi.org/10.1155/2019/5958032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644216PMC
July 2019
2 Reads

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma.

Can J Gastroenterol Hepatol 2019 7;2019:3960920. Epub 2019 Jul 7.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Plexiform fibromyxoma is a rare and newly described gastric mesenchymal tumor with only 121 reported cases in the literature. Our understanding of plexiform fibromyxoma requires updating since the first case has been reported by Takahashi et al. 12 years ago. Read More

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http://dx.doi.org/10.1155/2019/3960920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642755PMC

Analysis of Mortality and Survival Rate of Liver Cancer in Zhejiang Province in China: A General Population-Based Study.

Can J Gastroenterol Hepatol 2019 10;2019:1074286. Epub 2019 Jul 10.

Department of Noncommunicable Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China.

Background: Few accurate up-to-date studies provide liver cancer mortality and survival information in Zhejiang province. This research aimed to depict the mortality and survival of liver cancer in Zhejiang province in China during 2005-2010.

Methods: The data were collected from the Zhejiang Chronic Disease Surveillance Information and Management System, and the mortality rates of liver cancer were calculated by gender, age, and areas. Read More

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http://dx.doi.org/10.1155/2019/1074286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652059PMC
March 2020
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Laparoscopic Spleen-Preserving Distal Pancreatectomy (LSPDP) versus Open Spleen-Preserving Distal Pancreatectomy (OSPDP): A Comparative Study.

Can J Gastroenterol Hepatol 2019 1;2019:9367868. Epub 2019 Jul 1.

Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center, Medical School of Ningbo University, Ningbo, 315041 Zhejiang, China.

Objective: To compare outcomes between laparoscopic spleen-preserving distal pancreatectomy (LSPDP) and open spleen-preserving distal pancreatectomy (OSPDP) for treatment of benign and low-grade malignant tumors of the pancreas and evaluate feasibility and safety of LSPDP.

Methods: The clinical data of 53 cases of LSPDP and 44 cases of OSPDP performed between January 2008 and August 2018 were retrospectively analyzed. The clinical outcomes between the two groups were compared. Read More

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http://dx.doi.org/10.1155/2019/9367868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633873PMC
July 2019
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Mutations Conferring Resistance to Fluoroquinolones and Clarithromycin among Dyspeptic Patients Attending a Tertiary Hospital, Tanzania.

Can J Gastroenterol Hepatol 2019 1;2019:8481375. Epub 2019 Jul 1.

Department of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Bugando, Mwanza, Tanzania.

() isolates resistant to clarithromycin and quinolones are increasing worldwide. Data regarding the magnitude of resistance are limited in developing countries. Here, we report the prevalence of mutations conferring resistance to clarithromycin and fluoroquinolones among dyspeptic patients attending a tertiary hospital, Tanzania. Read More

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http://dx.doi.org/10.1155/2019/8481375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634059PMC
July 2019
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Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.

Can J Gastroenterol Hepatol 2019 1;2019:8348967. Epub 2019 Jul 1.

Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan 215300, China.

Objective: HMGCS2 is the rate-limiting enzyme of ketogenesis, which is vital for tumor initiation or metastasis. The aim of this study is to determine the relationship between HMGCS2 and tumor angiogenesis.

Materials And Methods: The study consisted of 100 cases with colorectal cancer and healthy control, the expression of HMGCS2 and the microvessel density (MVD) (marker: CD31) were analyzed by immunohistochemistry and tube formation, and the centration of -hydroxybutyrate in serum was assessed by biochemical analysis. Read More

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http://dx.doi.org/10.1155/2019/8348967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634068PMC

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries.

Can J Gastroenterol Hepatol 2019 1;2019:3413969. Epub 2019 Jul 1.

Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 211166, Jiangsu Province, China.

Background: Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA).

Methods: We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. Read More

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http://dx.doi.org/10.1155/2019/3413969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634076PMC
March 2020
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Direct Oral Anticoagulant Use and Risk of Diverticular Hemorrhage: A Systematic Review of the Literature.

Can J Gastroenterol Hepatol 2019 18;2019:9851307. Epub 2019 Jun 18.

Department of Medicine, Memorial University of Newfoundland, Medical Education Centre, 300 Prince Philip Drive, St. John's, NL, Canada A1B 3V6.

Background: Anticoagulants carry a significant risk of gastrointestinal bleeding. With the increase in use and availability of direct oral anticoagulants ("DOACs") more data are available regarding the risks of these medications. With diverticular bleeds being common, and hospitalization associated with gastrointestinal bleed increasing 30-day mortality, it is paramount to better understand the potential risks of using DOACs in this population. Read More

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http://dx.doi.org/10.1155/2019/9851307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604480PMC

The Prevalence of Helicobacter Pylori babA, homB, aspA, and sabA Genes and Its Relationship with Clinical Outcomes in Turkey.

Can J Gastroenterol Hepatol 2019 13;2019:1271872. Epub 2019 Jun 13.

Medical Biology and Genetics Department, Health Sciences İnstitute, University of Gaziantep, Turkey.

Background And Aims: The cag A and vac A genes of are closely associated with the pathogenicity of bacteria. However, the significance of H. pylori , and genes is not clear in phenotypic characteristics of virulence. Read More

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http://dx.doi.org/10.1155/2019/1271872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595381PMC
March 2020
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Ischemic Postconditioning (IPostC) Protects Fibrotic and Cirrhotic Rat Livers after Warm Ischemia.

Can J Gastroenterol Hepatol 2019 9;2019:5683479. Epub 2019 Jun 9.

Department of Medicine II, University Hospital, Liver Centre Munich, LMU Munich, Germany.

Background: Decreased organ function following liver resection is a major clinical issue. The practical method of ischemic postconditioning (IPostC) has been studied in heart diseases, but no data exist regarding fibrotic livers.

Aims: We aimed to determine whether IPostC could protect healthy, fibrotic, and cirrhotic livers from ischemia reperfusion injury (IRI). Read More

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https://www.hindawi.com/journals/cjgh/2019/5683479/
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http://dx.doi.org/10.1155/2019/5683479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590494PMC
June 2019
4 Reads

The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells.

Can J Gastroenterol Hepatol 2019 9;2019:3076345. Epub 2019 Jun 9.

Department of Gastroenterology, People's Hospital of Taizhou, 366 Taihu Road, Taizhou 225300, Jiangsu, China.

Background: Long noncoding RNAs (lncRNAs) are a group of noncoding RNA with the length of more than 200nt. They have been identified as important diagnostic and prognostic molecules for many cancers and play an important role in the development of cancers. However, their clinical value and roles in gastric cancer (GC) remain unclear. Read More

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http://dx.doi.org/10.1155/2019/3076345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590613PMC
March 2020
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Diagnostic Radiation Exposure in Patients with Inflammatory Bowel Disease.

Can J Gastroenterol Hepatol 2019 11;2019:2030735. Epub 2019 Jun 11.

Gastroenterology Division, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.

Background: Because of the chronic and relapsing nature of inflammatory bowel disease (IBD), which often requires characterization with CT scan, IBD patients might be exposed to a large amount of radiation. As a cumulative effective dose (CED) ≥ 100 mSv is considered significant for stochastic risks of cancer, it is important to monitor and control the radiation exposure of the IBD patients. In the present work, we aimed to quantify the mean CED in IBD patients to assess any harmful effects of radiation. Read More

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http://dx.doi.org/10.1155/2019/2030735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594263PMC
March 2020
2 Reads

Risk-Based Prenatal Hepatitis C Testing Practices and Results, Alaska 2013-2016.

Can J Gastroenterol Hepatol 2019 2;2019:8654741. Epub 2019 Jun 2.

Alaska Native Tribal Health Consortium, Anchorage, AK, USA.

Hepatitis C virus (HCV) infection in pregnant women is of concern as it presents a health threat not only to the mother, but also to her infant. A retrospective analysis was performed to evaluate HCV testing and exposure in women who delivered infants between 2013 and 2016 at a referral hospital in Alaska. Multiple risk behaviors were evaluated, including drug dependency or abuse (drug abuse), tobacco use, alcohol dependency or abuse, and late presentation to prenatal care. Read More

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http://dx.doi.org/10.1155/2019/8654741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582887PMC
June 2019
3 Reads

Concomitant Sjögren's Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis.

Can J Gastroenterol Hepatol 2019 2;2019:7396870. Epub 2019 Jun 2.

Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Aim: Patients with primary biliary cholangitis (PBC) have at least 60% probability of having an autoimmune extrahepatic condition, with the most common being Sjögren's syndrome (SS). The impacts of SS on the response and outcomes in ursodeoxycholic acid (UDCA)-treated patients with PBC, however, remain unclear. The aim of this study was to document the biochemical responses and clinical outcomes of UDCA-treated patients with concomitant SS and to compare the findings to those of patients with PBC alone. Read More

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http://dx.doi.org/10.1155/2019/7396870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582895PMC
June 2019
1 Read