533 results match your criteria Canadian Journal Of Gastroenterology And Hepatology[Journal]


Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study.

Can J Gastroenterol Hepatol 2019 5;2019:8747438. Epub 2019 Mar 5.

Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Selection and prioritization of patients with HCC for LT are based on pretransplant imaging diagnostic, taking the risk of incorrect diagnosis. According to the German waitlist guidelines, imaging has to be reported to the allocation organization (Eurotransplant) and pathology reports have to be submitted thereafter. In order to assess current procedures we performed a retrospective multicenter analysis in all German transplant centers with focus on accuracy of imaging diagnostic and tumor classification. Read More

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http://dx.doi.org/10.1155/2019/8747438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425358PMC
March 2019
2 Reads

Emerging Trends and New Developments in Transient Elastography: A Bibliometric and Cocitation Analysis from 1999 to 2017.

Can J Gastroenterol Hepatol 2019 5;2019:3280657. Epub 2019 Mar 5.

CHESS Frontier Center Working Party, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.

Purpose: To identify and characterize the 100 most-cited articles in the field of transient elastography.

Methods: The top-cited articles focusing on transient elastography from 1999 to 2017 were retrieved from Science Citation Index Expanded (SCI-E) database. The most prolific article, journal, country and continent, top-cited article in different period, international collaboration, cocitation analysis of journal were retrieved and analyzed in this article. Read More

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http://dx.doi.org/10.1155/2019/3280657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425420PMC

Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats.

Can J Gastroenterol Hepatol 2019 3;2019:9897315. Epub 2019 Mar 3.

Department of Zoology, Faculty of Sciences, Minia University, Minia, Egypt.

The elevated level of copper is one of the hallmark features of cancer cells in most of the types of cancer. In the present study, this feature has been targeted to investigate if coadministration of exogenous copper (Cu) and its chelating agent like disulfiram (DSF) influence the antineoplastic activity of the anticancer drug, Gleevec (GLV), in hepatocellular carcinoma (HCC)-induced rats via immunomodulation. After the treatment, the level of proinflammatory interleukins (IL-1, 2, 6, and 7), anti-inflammatory interleukin (IL-10) concomitant with transcription factors (NF-kB and TNF-a), and the apoptotic marker (cleaved PARP) was estimated. Read More

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http://dx.doi.org/10.1155/2019/9897315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421053PMC
March 2019
1 Read

Clinical Aspects and Prognosis Evaluation of Cirrhotic Patients Hospitalized with Acute Kidney Injury.

Can J Gastroenterol Hepatol 2019 3;2019:6567850. Epub 2019 Mar 3.

Graduate Program in Science Applied to Adult Health, Medical School, Federal University of Minas Gerais (Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais), Brazil.

Background: Acute kidney injury occurs in approximately 20% of hospitalized cirrhotic patients. Mortality is estimated at 60% within a month and 65% within a year.

Aims: To evaluate survival in 30 days and in 3 months of cirrhotic patients hospitalized with acute kidney injury, identifying factors associated with mortality. Read More

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http://dx.doi.org/10.1155/2019/6567850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421012PMC
March 2019
3 Reads

Parameters Suggesting Spontaneous Passage of Stones from Common Bile Duct: A Retrospective Study.

Can J Gastroenterol Hepatol 2019 3;2019:5382708. Epub 2019 Mar 3.

Department of Surgery, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

Background: Common bile duct (CBD) stones are common. However, they are known to pass spontaneously, which obviates the need for ERCP.

Aim: The aim of this study is to identify specific predictors for spontaneous passage of CBD stones. Read More

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http://dx.doi.org/10.1155/2019/5382708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420964PMC
March 2019
1 Read

Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation.

Can J Gastroenterol Hepatol 2019 3;2019:5036160. Epub 2019 Mar 3.

Division of Gastroenterology, Gastro-Intestinal Motility Center, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

Background: Jackhammer esophagus is a hypercontractile esophageal disorder recently brought to light with the advent of high resolution manometry (HRM). As little is known about its clinical presentation, the aim of this study was to identify the clinical characteristics associated with this new gastrointestinal motility disorder.

Methods: A retrospective study was conducted on patients visiting the CHUM's Gastro-Intestinal Motility Center from January 2015 to December 2017. Read More

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http://dx.doi.org/10.1155/2019/5036160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421016PMC
March 2019
3 Reads

Hepatocellular Carcinoma: From Molecular Basis to Novel Treatment Approaches.

Authors:
Hikmet Akkız

Can J Gastroenterol Hepatol 2019 3;2019:4970731. Epub 2019 Mar 3.

Professor of Gastroenterology and Hepatology, Head of Gastroenterology and Hepatology, Çukurova University, Turkey.

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http://dx.doi.org/10.1155/2019/4970731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420995PMC
March 2019
2 Reads

Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy.

Can J Gastroenterol Hepatol 2019 3;2019:4029541. Epub 2019 Mar 3.

Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok, Poland.

Background And Aim: The development of interferon- (IFN-) free regimens substantially improved efficacy of treatment for HCV, but despite excellent effectiveness the failures still occur. The aim of our study was to evaluate the efficacy of retreatment with genotype specific direct acting antivirals- (DAA-) based regimens in nonresponders to previous IFN-free therapy.

Materials And Methods: Analysed population consisted of 31 nonresponders to IFN-free regimen, which received second IFN-free rescue therapy, selected from 6228 patients included in a national database EpiTer-2. Read More

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http://dx.doi.org/10.1155/2019/4029541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420981PMC
March 2019
1 Read

Gastrointestinal Cancers: Molecular Genetics and Biomarkers.

Can J Gastroenterol Hepatol 2018 18;2018:4513860. Epub 2018 Oct 18.

Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

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http://dx.doi.org/10.1155/2018/4513860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420989PMC
October 2018

Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma.

Can J Gastroenterol Hepatol 2019 7;2019:9015453. Epub 2019 Feb 7.

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive.

Aim: To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. Read More

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http://dx.doi.org/10.1155/2019/9015453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383407PMC
February 2019
1 Read

Noninvasive Predictors of High-Risk Varices in Patients with Non-Cirrhotic Portal Hypertension.

Can J Gastroenterol Hepatol 2019 7;2019:1808797. Epub 2019 Feb 7.

Toronto Centre for Liver Disease, University Hospital Network, Toronto M5G 2C4, Canada.

Non-cirrhotic portal hypertension (NCPH) comprises a heterogeneous group of liver disorders causing portal hypertension without cirrhosis and carries a high risk of variceal bleeding. Recent guidelines, based largely on patients with viral cirrhosis, suggest low likelihood of high risk varices (HRV) in patients with a liver stiffness measurement (LSM) <20 kPa and platelet count >150 × 10/L. In NCPH, LSM is often higher than healthy controls but lower than matched cirrhotic patients. Read More

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http://dx.doi.org/10.1155/2019/1808797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383430PMC
February 2019
3 Reads

Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases.

Can J Gastroenterol Hepatol 2019 3;2019:8581743. Epub 2019 Feb 3.

Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Background And Aims: Several studies have shown the benefits of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using a Franseen needle for histological assessment. However, studies focusing on pancreatic diseases are limited and the safety of this method has not been well assessed. We aimed to assess the current status and issues of EUS-FNB in the diagnosis of pancreatic diseases. Read More

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http://dx.doi.org/10.1155/2019/8581743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377986PMC
February 2019

Concordance Rate between Clinicians and Watson for Oncology among Patients with Advanced Gastric Cancer: Early, Real-World Experience in Korea.

Can J Gastroenterol Hepatol 2019 3;2019:8072928. Epub 2019 Feb 3.

Department of Neurosurgery and Director of AI-Based Precision Medicine, Gil Medical Center, Gachon University, Incheon, Republic of Korea.

Backgrounds/aims: Watson for Oncology (WFO) is a cognitive technology that processes medical information by analyzing the latest evidence and guidelines. However, studies of the concordance rate between WFO and clinicians for advanced gastric cancer (AGC) are lacking.

Methods: We retrospectively reviewed 65 patients with AGC who consulted WFO and the Gachon Gil Medical Center multidisciplinary team (GMDT) in 2016 and 2017. Read More

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http://dx.doi.org/10.1155/2019/8072928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377977PMC
February 2019

Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease.

Can J Gastroenterol Hepatol 2019 3;2019:6415757. Epub 2019 Feb 3.

Gastroenterology and Endoscopy United, The Nazareth Hospital, EMMS, Nazareth, Bar Ilan University, Tel-Aviv, Israel.

Background And Aims: We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease. In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common. Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. Read More

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https://www.hindawi.com/journals/cjgh/2019/6415757/
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http://dx.doi.org/10.1155/2019/6415757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378002PMC
February 2019
8 Reads

Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress.

Can J Gastroenterol Hepatol 2019 3;2019:5413461. Epub 2019 Feb 3.

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Animal models of obstructive cholestasis and ischemia/reperfusion damage have revealed the functional heterogeneity of liver lobes. This study evaluates this heterogeneity in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) rat models. Twelve-week-old Obese and Lean male Zucker rats were used for NAFLD. Read More

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http://dx.doi.org/10.1155/2019/5413461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378039PMC
February 2019
1 Read

Myenteric Denervation of the Gut with Benzalkonium Chloride: A Review of Forty Years of an Experimental Model.

Can J Gastroenterol Hepatol 2019 3;2019:3562492. Epub 2019 Feb 3.

Department of Toxicology, Bromatology, and Clinical Analysis, University of Sao Paulo, Av. Bandeirantes 3900, 14, Ribeirão Preto 049-900, Brazil.

Experimental denervation of organs plays a key role in understanding the functional aspects of the normal innervation as well as the diseases related to them. In 1978 the experimental model of myenteric denervation of the rat gut by serosal application of benzalkonium chloride (BAC) was proposed. BAC is a positively charged surface-active alkylamine and is a powerful cationic detergent, which destroys bacteria after ionic attraction and for this reason is largely used as a surgical antiseptic. Read More

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http://dx.doi.org/10.1155/2019/3562492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378025PMC
February 2019
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Ilececum: A Comprehensive Review.

Can J Gastroenterol Hepatol 2019 3;2019:1451835. Epub 2019 Feb 3.

Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, USA.

For gastrointestinal endoscopists, the ileocecum is the finishing line during colonoscopy and it is identified by three endoscopic landmarks: terminal ileum, ileocecal valve, and the appendiceal orifice. Although ileal intubation is recommended during routine screening colonoscopy, it is not required in most cases of screening colonoscopy. Ileal intubation is indicated in certain circumstances such as suspected inflammatory bowel disease and GI bleeding. Read More

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https://www.hindawi.com/journals/cjgh/2019/1451835/
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http://dx.doi.org/10.1155/2019/1451835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378086PMC
February 2019
2 Reads

Gastrointestinal Tract Disorders in Older Age.

Can J Gastroenterol Hepatol 2019 17;2019:6757524. Epub 2019 Jan 17.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging. Gastrointestinal (GI) changes in the elderly are common, and despite some GI disorders being more prevalent in the elderly, there is no GI disease that is limited to this age group. While some changes associated with aging GI system are physiologic, others are pathological and particularly more prevalent among those above age 65 years. Read More

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http://dx.doi.org/10.1155/2019/6757524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354172PMC
January 2019

Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations.

Can J Gastroenterol Hepatol 2019 8;2019:4383269. Epub 2019 Jan 8.

The Department of Gastroenterology at Staten Island University Hospital, Northwell Health, USA.

The introduction of Direct Oral Anticoagulants (DOACs) to the pharmaceutical market provided patients and clinicians with novel convenient and safe options of anticoagulation. The use of this class of medications is currently limited to venous thromboembolic therapy and prophylaxis, in addition to stroke prophylaxis in patients with nonvalvular atrial fibrillation. Despite their altered hemostasis, patients with cirrhosis are thought to be in a procoagulant state and thus prone to thrombus formation. Read More

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http://dx.doi.org/10.1155/2019/4383269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354142PMC
January 2019
1 Read

HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation.

Can J Gastroenterol Hepatol 2019 17;2019:2509059. Epub 2019 Jan 17.

Division of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Background: The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate recurrent HCC. Read More

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http://dx.doi.org/10.1155/2019/2509059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354133PMC
January 2019

Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials.

Can J Gastroenterol Hepatol 2019 10;2019:3192351. Epub 2019 Jan 10.

Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.

Background: Prophylactic therapy with silymarin to prevent the development of antituberculosis drug-induced liver injury (anti-TB DILI) has been under debate. We aimed to evaluate the effect of silymarin in the prevention of anti-TB DILI.

Methods: We searched MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to 30th November 2018. Read More

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https://www.hindawi.com/journals/cjgh/2019/3192351/
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http://dx.doi.org/10.1155/2019/3192351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348824PMC
January 2019
3 Reads

Investigation of the Local Recurrence Rate after Colorectal Endoscopic Mucosal Resection: Is Incomplete Polyp Resection Really a Clinically Important Problem? Analysis of the Rationale for the "Resect and Discard" Strategy.

Can J Gastroenterol Hepatol 2019 8;2019:7243515. Epub 2019 Jan 8.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan.

Background/aims: The "Resect and Discard" strategy is a potentially useful strategy. At present, only the lesion size and accuracy of diagnosis are cited as considerations for clinical adoption of this strategy. On the other hand, histopathology of the resected specimens after Endoscopic Mucosal Resection (EMR) reveals often an unclear or positive-margin status, implying Incomplete Polyp Resection (IPR). Read More

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http://dx.doi.org/10.1155/2019/7243515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341238PMC
January 2019

Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation.

Can J Gastroenterol Hepatol 2019 8;2019:5796074. Epub 2019 Jan 8.

Department of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, Germany.

Background: Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies.

Methods: All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study. Read More

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https://www.hindawi.com/journals/cjgh/2019/5796074/
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http://dx.doi.org/10.1155/2019/5796074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341263PMC
January 2019
12 Reads

Liver and Spleen Stiffness Measurements for Assessment of Portal Hypertension Severity in Patients with Budd Chiari Syndrome.

Can J Gastroenterol Hepatol 2019 2;2019:1673197. Epub 2019 Jan 2.

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Italy.

Aims: Budd-Chiari Syndrome (BCS) is a rare vascular disease of the liver caused by the obstruction of the hepatic venous outflow located from the small hepatic venules up to the entrance of the inferior vena cava (IVC) into the right atrium. Current prognostic indexes are suboptimal for an individual prognostic assessment and subsequent management of patients with BCS. Liver (LSM) and spleen (SSM) stiffness measurements are widely validated prognostic tools in hepatology, but the evidence in patients with BCS is limited. Read More

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http://dx.doi.org/10.1155/2019/1673197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334356PMC
January 2019
6 Reads

Comment on "48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse".

Can J Gastroenterol Hepatol 2019 1;2019:4927083. Epub 2019 Jan 1.

Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

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https://www.hindawi.com/journals/cjgh/2019/4927083/
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http://dx.doi.org/10.1155/2019/4927083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333002PMC
March 2019
12 Reads

High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?

Can J Gastroenterol Hepatol 2018 23;2018:4980597. Epub 2018 Dec 23.

Regional Advisory Unit for Imported and Tropical Diseases, Oslo University Hospital Ullevål, Oslo, Norway.

Background: Recent studies have identified chewing of khat () as an independent risk factor for liver injury; however, the pathogenetic mechanism remains poorly understood. Case series have found markers of autoimmune hepatitis in patients with khat-related liver disease, suggesting that khat chewing might trigger an autoimmune response. The aims of the present study were (i) to assess the prevalence of autoantibodies typical for autoimmune liver diseases in a healthy population in Ethiopia and (ii) to explore the hypothesis that khat usage triggers autoimmunity. Read More

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http://dx.doi.org/10.1155/2018/4980597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323432PMC
December 2018
2 Reads

AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats.

Can J Gastroenterol Hepatol 2018 19;2018:6181432. Epub 2018 Dec 19.

Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Background: To evaluate the AMP-activated protein kinase- (AMPK-) mediated signaling and NF-B-related inflammatory pathways that contribute to cholestatic diseases in the bile duct ligation (BDL) rat model of chronic cholestasis and verify the protective role of 5-Aminoimidazole-4-carboxamide1--D-ribofuranoside (AICAR) against hepatic injury and fibrosis triggered by cholestasis-related inflammation.

Methods: Animals were randomly divided into three groups: sham-operated group, BDL group, and BDL+ AICAR group. Cholestatic liver injury was induced by common BDL. Read More

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http://dx.doi.org/10.1155/2018/6181432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314002PMC
December 2018
1 Read

Usefulness of a Cannula with a Flexible Tip (Swing Tip) for Managing Severe Biliary Stricture.

Can J Gastroenterol Hepatol 2018 12;2018:7125714. Epub 2018 Dec 12.

Department of Gastroenterology, Okayama University Hospital, Okayama, Japan.

Background And Aims: Biliary stenting for the treatment of biliary stricture is the most common indication of ERCP, but the procedure is sometimes unsuccessful because of severe strictures. The Swing Tip is useful for passing through severe strictures because it has a manually operable tip. The efficacy of using a Swing Tip was retrospectively evaluated. Read More

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http://dx.doi.org/10.1155/2018/7125714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311258PMC
December 2018

Comment on "Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease".

Can J Gastroenterol Hepatol 2018 16;2018:6747630. Epub 2018 Dec 16.

Intensive Care Unit, Sun Yat-sen University Cancer Center, Guangzhou 510515, China.

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http://dx.doi.org/10.1155/2018/6747630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311232PMC
February 2019

Changes of the Fatty Acid Profile in Erythrocyte Membranes of Patients following 6-Month Dietary Intervention Aimed at the Regression of Nonalcoholic Fatty Liver Disease (NAFLD).

Can J Gastroenterol Hepatol 2018 4;2018:5856201. Epub 2018 Dec 4.

Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland.

Background: Nonalcoholic fatty liver disease (NAFLD) is closely related to the metabolism disorders of fatty acids. The pathogenesis of the disease includes an increased concentration of FFA in blood, an increase in the biosynthesis of fatty acids, and disorders in the process of -oxidation.

Objective: The aim of the study was to analyze the fatty acids in erythrocyte membranes among 55 patients with NAFLD who were subjected to a 6-month dietary intervention in order to reduce fatty liver. Read More

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https://www.hindawi.com/journals/cjgh/2018/5856201/
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http://dx.doi.org/10.1155/2018/5856201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304595PMC
December 2018
12 Reads

Fecal Elastase Levels Predict Honeycombing in Pancreas Detected with Endoscopic Ultrasound.

Can J Gastroenterol Hepatol 2018 2;2018:4625247. Epub 2018 Dec 2.

Katip Celebi University Ataturk Teaching and Research Hospital Gastroenterology Clinic, Izmir, Turkey.

Background And Study Aims: We aimed to demonstrate the association between fecal elastase levels and Rosemont categories in patients with chronic changes in pancreas detected with endoscopic ultrasound.

Patients And Methods: Patients were selected consecutively from endosonography examinations performed for upper gastrointestinal subepithelial lesions and for pancreas evaluation. Pancreas imaging findings were categorized according to the Rosemont criteria using echoendoscope. Read More

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http://dx.doi.org/10.1155/2018/4625247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304647PMC
December 2018
4 Reads

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development.

Can J Gastroenterol Hepatol 2018 2;2018:4601420. Epub 2018 Dec 2.

Hospital Corporation of America, East Florida Division, Fort Lauderdale, FL, USA.

is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with remain asymptomatic, some present with amoebic colitis and disseminated disease. Read More

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http://dx.doi.org/10.1155/2018/4601420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304615PMC
December 2018
1 Read

The Natural History of Incidental Colonic Diverticulosis on Screening Colonoscopy.

Can J Gastroenterol Hepatol 2018 6;2018:3690202. Epub 2018 Dec 6.

Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: The natural history of colonic diverticulosis is unclear.

Methods: Patients with incidental diverticulosis identified in a previous prospective cross-sectional screening colonoscopy study were evaluated retrospectively for clinic or hospital visit(s) for diverticular disease (DD= acute diverticulitis or diverticular bleeding) using review of electronic health records and patient phone interview.

Results: 826 patients were included in the screening colonoscopy study. Read More

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http://dx.doi.org/10.1155/2018/3690202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304544PMC
December 2018
3 Reads

Effect of Admission Time on the Outcomes of Liver Cirrhosis with Acute Upper Gastrointestinal Bleeding: Regular Hours versus Off-Hours Admission.

Can J Gastroenterol Hepatol 2018 29;2018:3541365. Epub 2018 Nov 29.

Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, 110840, China.

Background And Aims: Acute upper gastrointestinal bleeding (AUGIB) is a lethal complication of liver cirrhosis. We aimed to compare the outcomes of patients with liver cirrhosis and AUGIB who were admitted to hospital on regular hours and off-hours.

Methods: This retrospective study screened all cirrhotic patients with AUGIB who were admitted to our hospital from January 2010 to June 2014 for the test cohort and from December 2014 to March 2018 for the validation cohort. Read More

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http://dx.doi.org/10.1155/2018/3541365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304553PMC
November 2018
2 Reads

Sofosbuvir-Based Therapies for Patients with Hepatitis C Virus Infection: Real-World Experience in China.

Can J Gastroenterol Hepatol 2018 13;2018:3908767. Epub 2018 Nov 13.

Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background And Aims: There is scarcity of data in literature regarding the treatment response to sofosbuvir- (SOF-) based therapies in Chinese patients with chronic Hepatitis C Virus (HCV) infection. The aim of this study was to evaluate the efficacy and safety of SOF-based regimens for chronic hepatitis C (CHC) patients without cirrhosis in a real-world setting in mainland China.

Methods: A total of 226 patients receiving SOF plus daclatasvir (DCV), ledipasvir (LDV), or velpatasvir (VEL) were enrolled from December 2014 to June 2017. Read More

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http://dx.doi.org/10.1155/2018/3908767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258099PMC
November 2018
1 Read

The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer.

Can J Gastroenterol Hepatol 2018 7;2018:7628763. Epub 2018 Nov 7.

College of Animal Science and Veterinary Medicine, Henan institute of Science and Technology, Xinxiang, Henan, 453003, China.

Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. Read More

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http://dx.doi.org/10.1155/2018/7628763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247728PMC
November 2018

Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients.

Can J Gastroenterol Hepatol 2018 7;2018:5681979. Epub 2018 Nov 7.

Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.

Background & Aims: The significance of short-term changes in model for end-stage liver disease and Sodium (MELD-Na) following hepatocellular carcinoma (HCC) diagnosis is unknown. In this report, we explore the value of the rate of short-term changes in MELD-Na as an independent predictor of mortality in patients with nonmetastatic HCC.

Methods: We reviewed a cohort of patients diagnosed with nonmetastatic HCC at our institution between 2001 and 2011. Read More

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http://dx.doi.org/10.1155/2018/5681979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247644PMC
November 2018

Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy.

Can J Gastroenterol Hepatol 2018 5;2018:9450754. Epub 2018 Nov 5.

University of Calgary, Calgary, Canada.

Colorectal cancer is the second most common malignancy diagnosed in Canada. Despite declining incidence and mortality rates in recent years, there is still a significant number of cases that are metastatic at presentation. Fluoropyrimidine-based chemotherapy was the backbone of colorectal cancer treatment, but the addition of irinotecan and oxaliplatin to form combination regimens has significantly improved overall survival. Read More

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http://dx.doi.org/10.1155/2018/9450754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241232PMC
November 2018
1 Read

Chronic Viral Hepatitis and Metabolic Syndrome/Cardiovascular Risk.

Can J Gastroenterol Hepatol 2018 4;2018:7369314. Epub 2018 Nov 4.

Halberg Hospital and Research Institute, Moradabad, India.

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http://dx.doi.org/10.1155/2018/7369314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241355PMC
November 2018
2 Reads

Portal Hypertension.

Can J Gastroenterol Hepatol 2018 4;2018:1289156. Epub 2018 Nov 4.

Medicina Interna 1, ARNAS-Civico, Di Cristina-Benfratelli, Palermo, Italy.

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http://dx.doi.org/10.1155/2018/1289156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241334PMC
November 2018
1 Read

Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy.

Can J Gastroenterol Hepatol 2018 1;2018:1275720. Epub 2018 Nov 1.

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Background: It is a novel idea that platelet counts may be associated with postoperative outcome following liver surgery. This may help in planning an extended hepatectomy (EH), which is a surgical procedure with high morbidity and mortality.

Aim: The aim of this study was to evaluate the predictive potential of platelet counts on the outcome of EH in patients without portal hypertension, splenomegaly, or cirrhosis. Read More

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http://dx.doi.org/10.1155/2018/1275720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236772PMC
November 2018
1 Read

Analysis of the Patient Information Quality and Readability on Esophagogastroduodenoscopy (EGD) on the Internet.

Can J Gastroenterol Hepatol 2018 29;2018:2849390. Epub 2018 Oct 29.

Department of Medicine, Section of Digestive diseases, West Virginia University Hospitals, Morgantown, WV, USA.

Objective: Patients are increasingly using the Internet to inform themselves of health-related topics and procedures, including EGD. We analyzed the quality of information and readability of websites after a search on 3 different search engines.

Methods: We used an assessment tool for website quality analysis that we developed in addition to using validated instruments for website quality, Global Quality Score (GQS) and Health on Net (HON) certification. Read More

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https://www.hindawi.com/journals/cjgh/2018/2849390/
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http://dx.doi.org/10.1155/2018/2849390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231384PMC
October 2018
15 Reads

Pleiotropic Effects of Heparins: From Clinical Applications to Molecular Mechanisms in Hepatocellular Carcinoma.

Can J Gastroenterol Hepatol 2018 22;2018:7568742. Epub 2018 Oct 22.

Izmir Biomedicine and Genome Center, 35340, Turkey.

Hepatocellular carcinoma (HCC) is a major health problem worldwide and most cases are incurable because of late presentation. It is the most common primary neoplasm of the liver and often arises in the context of a chronic liver disease that impairs coagulation. Portal vein thrombosis (PVT) is a common complication of HCC that is associated with a poor prognosis. Read More

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https://www.hindawi.com/journals/cjgh/2018/7568742/
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http://dx.doi.org/10.1155/2018/7568742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217885PMC
October 2018
12 Reads

"Fatal Gastrointestinal and Peritoneal Ischemic Disease" of Unknown Cause at Arba Minch Hospital, Southern Ethiopia.

Can J Gastroenterol Hepatol 2018 23;2018:6598960. Epub 2018 Oct 23.

Department of Internal Medicine, Saint Paul's Hospital Millennium Medical College, Ethiopia.

Gastrointestinal and peritoneal ischemic disease due to unknown etiology present with intestinal obstruction and/or peritonitis otherwise in healthy patient emerged as fatal disease at Arba Minch General Hospital. This disorder was diagnosed based on intraoperative finding. Clinical presentation and natural history of disease progression were similar. Read More

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https://www.hindawi.com/journals/cjgh/2018/6598960/
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http://dx.doi.org/10.1155/2018/6598960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218790PMC
October 2018
13 Reads

Gastric Peroral Endoscopic Myotomy (G-POEM) as a Treatment for Refractory Gastroparesis: Long-Term Outcomes.

Can J Gastroenterol Hepatol 2018 22;2018:6409698. Epub 2018 Oct 22.

Endoscopy Centre and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background And Aims: Gastric peroral endoscopic myotomy (G-POEM) has been regarded as a novel and minimally invasive therapy for refractory gastroparesis. This study reports the long-term outcomes and possible predictive factors for successful outcomes after G-POEM in an Asian population.

Methods: This is a retrospective single-centre study of 16 patients who underwent G-POEM for refractory gastroparesis from August 2016 to October 2017. Read More

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https://www.hindawi.com/journals/cjgh/2018/6409698/
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http://dx.doi.org/10.1155/2018/6409698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217887PMC
October 2018
17 Reads

Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis.

Can J Gastroenterol Hepatol 2018 15;2018:8410195. Epub 2018 Oct 15.

Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.

Some long noncoding RNAs (lncRNAs) display aberrantly high or low expression in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic biomarkers. Here, we accomplished a meta-analysis based on current studies to assess the diagnostic value of lncRNAs in HCC. Eligible literatures were systematically selected from PubMed, Web of Science, and Embase (up to January 20, 2018) according to defined inclusion and exclusion criteria. Read More

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https://www.hindawi.com/journals/cjgh/2018/8410195/
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http://dx.doi.org/10.1155/2018/8410195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205093PMC
October 2018
15 Reads

Gastric Cancer Cell Lines Have Different -Regulated Expression Patterns but Share a Common Core of Altered Genes.

Can J Gastroenterol Hepatol 2018 16;2018:5804376. Epub 2018 Oct 16.

Laboratory of Molecular Biology, Ophir Loyola Hospital, Belém, Brazil.

is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified -regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and metastasis). The DEGs were picked using software, followed by Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis using KEGG. Read More

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https://www.hindawi.com/journals/cjgh/2018/5804376/
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http://dx.doi.org/10.1155/2018/5804376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206580PMC
October 2018
19 Reads

Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals.

Can J Gastroenterol Hepatol 2018 3;2018:6095097. Epub 2018 Oct 3.

1st Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, Trieda SNP 1, Kosice, 04001, Slovakia.

Background And Aims: Chronic hepatitis C is a systemic disease and type 2 diabetes mellitus (T2DM) belongs to more common extrahepatic. The aim of this study was to (i) explore the prevalence of impaired fasting glucose (IFG) and T2DM in patients with chronic hepatitis C, (ii) explore the effect of direct acting antivirals (DAA) treatment on the glycemia, and (iii) explore the factors that modulate the effect of DAA treatment on glycemia in patients with chronic hepatitis C.

Methods: We performed a longitudinal retrospective observational study focused on the patients undergoing DAA treatment of chronic hepatitis C. Read More

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https://www.hindawi.com/journals/cjgh/2018/6095097/
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http://dx.doi.org/10.1155/2018/6095097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192081PMC
October 2018
4 Reads

Acute-on-Chronic Liver Failure: From Basic Research to Clinical Applications.

Can J Gastroenterol Hepatol 2018 8;2018:5029789. Epub 2018 Oct 8.

Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.

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https://www.hindawi.com/journals/cjgh/2018/5029789/
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http://dx.doi.org/10.1155/2018/5029789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196885PMC
October 2018
19 Reads

Increased CCR7PD-1CXCR5CD4 T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection.

Can J Gastroenterol Hepatol 2018 8;2018:1020925. Epub 2018 Oct 8.

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

T follicular helper cells (Tfh cells) affect essential immune pathogenesis in chronic hepatitis B virus (HBV) infection. The CCR7PD-1 Tfh subset has a partial Tfh effector phenotype and is associated with active Tfh differentiation, whereas the CCR7PD-1 Tfh subset is a resting phenotype. We recruited 20 healthy volunteers and 77 patients with chronic HBV infection, including those in the immune tolerant (IT) phase (n=19), immune clearance (IC) phase (n=20), low replicative (LR) phase (n=18), and reactivation (RA) phase (n=20). Read More

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https://www.hindawi.com/journals/cjgh/2018/1020925/
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http://dx.doi.org/10.1155/2018/1020925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196997PMC
October 2018
11 Reads