127,016 results match your criteria Canadian Journal Of Electrical And Computer Engineering-revue Canadienne De Genie Electrique Et Informatique[Journal]


Role of inflammasomes in innate host defense against Entamoeba histolytica.

J Leukoc Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada.

Intestinal amebiasis is the disease caused by the extracellular protozoan parasite Entamoeba histolytica (Eh) that induces a dynamic and heterogeneous interaction profile with the host immune system during disease pathogenesis. In 90% of asymptomatic infection, Eh resides with indigenous microbiota in the outer mucus layer of the colon without prompting an immune response. However, for reasons that remain unclear, in a minority of the Eh-infected individuals, this fine tolerated relationship is switched to a pathogenic phenotype and advanced to an increasingly complex host-parasite interaction. Read More

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http://dx.doi.org/10.1002/JLB.3MR0420-465RDOI Listing

Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

San Raffaele Pisana Scientific Institute, Rome, Italy.

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has important implications for the safety of participants in clinical trials and the research staff caring for them and, consequently, for the trials themselves. Patients with heart failure may be at greater risk of infection with COVID-19 and the consequences might also be more serious, but they are also at risk of adverse outcomes if their clinical care is compromised. As physicians and clinical trialists, it is our responsibility to ensure safe and effective care is delivered to trial participants without affecting the integrity of the trial. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa461DOI Listing

Systemic therapy in metastatic renal cell carcinoma: Emerging challenges in therapeutic choice.

Crit Rev Oncol Hematol 2020 Jun 1;152:102971. Epub 2020 Jun 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada; Canadian Centre for Applied Research in Cancer Control, Toronto, Ontario, Canada. Electronic address:

The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone a substantial evolution in the past decade, with a dramatic increase in the number of available systemic therapies. Although this offers promise for improved patient outcomes, this rapid pace in development has led to new challenges in therapeutic choice. For instance, the absence of direct comparative evidence across all therapeutic options has led to a critical gap in evidence to clearly define preferred systemic therapy choice. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102971DOI Listing

A five-gene molecular phylogeny reveals Parapanteles Ashmead (Hymenoptera: Braconidae) to be polyphyletic as currently composed.

Mol Phylogenet Evol 2020 Jun 1:106859. Epub 2020 Jun 1.

Department of Entomology, University of Illinois Urbana-Champaign, Urbana IL 61801. Electronic address:

Parapanteles Ashmead (Braconidae: Microgastrinae) is a medium-sized genus of microgastrine wasps that was erected over a century ago and lacks a unique synapomorphic character, and its monophyly has not been tested by any means. Parapanteles usually are parasitoids of large, unconcealed caterpillars (macrolepidoptera) and have been reared from an unusually large diversity of hosts for a relatively small microgastrine genus. We used Cytochrome Oxidase I sequences ("DNA barcodes") available for Parapanteles and other microgastrines to sample the generic diversity of described and undescribed species currently placed in Parapanteles, and then sequenced four additional genes for this subsample (wingless, elongation factor 1-alpha, ribosomal subunit 28s, and NADH dehydrogenase subunit 1). Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106859DOI Listing

Functional PVDF ultrafiltration membrane for Tetrabromobisphenol-A (TBBPA) removal with high water recovery.

Water Res 2020 May 18;181:115952. Epub 2020 May 18.

Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada; Institute for Energy, Environment and Sustainable Communities, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.

Tetrabromobisphenol-A (TBBPA) is one of the most important brominated flame retardants (BFRs), accounting for 60% of the total commercial BFR market. Increasing amounts of TBBPA and byproducts are released to the aquatic environment due to their extensive utilization in various sectors. However, research on the treatment of TBBPA contaminated wastewater using membrane filtration is still lacked. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115952DOI Listing

Proceeding report of the fourth Symposium on Hidradenitis Suppurativa Advances (SHSA) 2019.

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

The Rockefeller University, New York, NY.

The 4 Annual Symposium on Hidradenitis Suppurativa (SHSA) took place on 1-3 November 2019 at the Westin Book Cadillac Hotel in Detroit, Michigan, U.S.A. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.114DOI Listing

Barriers to the Recognition of Geriatric Depression in Residential Care Facilities in Alberta.

Issues Ment Health Nurs 2020 Jun 4:1-12. Epub 2020 Jun 4.

Faculty of Social Work, University of Calgary, Calgary, Canada.

This study explored the barriers that regulated nurse professionals encountered in recognizing and assessing geriatric depression in residential care facilities in the Canadian province of Alberta. The study used a convergent parallel mixed methods design, including a cross-sectional survey ( = 635) and qualitative interviews ( = 14) with regulated nurse professionals. Findings revealed six major barriers to the recognition of geriatric depression in Alberta, including 1) insufficient clinical knowledge and training in geriatric depression; 2) misconceived beliefs about geriatric depression; 3) limited access to resources; 4) unclear depression assessment protocol and procedures in facilities; 5) characteristics of models of care and organizational culture in facilities; and 6) communication difficulties among all stakeholders in the process. Read More

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http://dx.doi.org/10.1080/01612840.2020.1742258DOI Listing

The effect of metformin vs placebo on sex hormones in CCTG MA.32.

J Natl Cancer Inst 2020 Jun 4. Epub 2020 Jun 4.

Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Canada.

Background: Metformin has been associated with lower breast cancer risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered sex hormones (SHs). We evaluated the effect of metformin on SHs in MA. Read More

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http://dx.doi.org/10.1093/jnci/djaa082DOI Listing

Development and Validation of the Chronic Disease Population Risk Tool (CDPoRT) to Predict Incidence of Adult Chronic Disease.

JAMA Netw Open 2020 Jun 1;3(6):e204669. Epub 2020 Jun 1.

Dalla Lana School of Public Health, Division of Epidemiology, University of Toronto, Toronto, Ontario, Canada.

Importance: Predicting chronic disease incidence for the population provides a comprehensive picture to health policy makers of their jurisdictions' overall future chronic disease burden. However, no population-based risk algorithm exists for estimating the risk of first major chronic disease.

Objective: To develop and validate the Chronic Disease Population Risk Tool (CDPoRT), a population risk algorithm that predicts the 10-year incidence of the first major chronic disease in the adult population. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.4669DOI Listing

Assessing the genomic relatedness and evolutionary rates of persistent verotoxigenic serotypes within a closed beef herd in Canada.

Microb Genom 2020 Jun 4. Epub 2020 Jun 4.

National Microbiology Laboratory, Public Health Agency of Canada, Lethbridge, Alberta, Canada.

Verotoxigenic (VTEC) are food- and water-borne pathogens associated with both sporadic illness and outbreaks of enteric disease. While it is known that cattle are reservoirs of VTEC, little is known about the genomic variation of VTEC in cattle, and whether the variation in genomes reported for human outbreak strains is consistent with individual animal or group/herd sources of infection. A previous study of VTEC prevalence identified serotypes carried persistently by three consecutive cohorts of heifers within a closed herd of cattle. Read More

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http://dx.doi.org/10.1099/mgen.0.000376DOI Listing

Medical research during a pandemic.

Can J Surg 2020 Jun 4;63(3):E313. Epub 2020 Jun 4.

Co-editors-in-chief, Canadian Journal of Surgery.

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http://dx.doi.org/10.1503/cjs.010220DOI Listing

Definition of pulmonary embolism-related death and classification of the cause of death in venous thromboembolism studies: Communication from the SSC of the ISTH.

J Thromb Haemost 2020 Jun;18(6):1495-1500

Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Pulmonary embolism (PE)-related death is often a component of the primary outcome in venous thromboembolism (VTE) clinical studies. Definitions for PE-related death vary widely, which may lead to biased risk estimates of clinical outcomes, thereby affecting both internal and external validity of study results. We here provide a standardized definition of PE-related death and propose guidance for classification and reporting of the cause of death for clinical studies in VTE. Read More

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http://dx.doi.org/10.1111/jth.14769DOI Listing

High occurrence rate of xanthomatosis and nephrocalcinosis in aquarium-housed Atlantic wolffish Anarhichas lupus and spotted wolffish A. minor.

Dis Aquat Organ 2020 Jun 4;139:223-232. Epub 2020 Jun 4.

Centre québécois sur la santé des animaux sauvages/Canadian Wildlife Health Cooperative, Faculté de médecine vétérinaire, Université de Montréal, St. Hyacinthe, Quebec J2S 8H5, Canada.

The Atlantic wolffish (AW) and the spotted wolffish (SW) are long-lived fish found in the North Atlantic and Arctic oceans and are respectively classified as special concern and threatened species, mainly due to fisheries bycatch. To better understand health issues associated with the care of these species in public aquaria, reports from all necropsies performed in 2 zoological institutions between 2009 and 2019 were reviewed (31 AW and 8 SW). These wolffish were fed with a similar fish-based diet and kept in multi-species exhibits with comparable environmental parameters. Read More

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http://dx.doi.org/10.3354/dao03477DOI Listing

Knowledge and Perceptions of Plant-Based Diets among Competitive and Recreational Athletes.

Can J Diet Pract Res 2020 Jun 4:1-6. Epub 2020 Jun 4.

School of Nutrition, Ryerson University, Toronto, ON.

Little is known about athletes' perceptions of emerging dietary guidance on plant-based diets (PBD). To explore knowledge and perceptions of PBD among competitive and recreational athletes, an online survey was developed, pilot tested, and sent via email to athletes recruited from 2 Canadian post-secondary institutions. Survey questions explored athletes' understanding and views of the proposed Canadian dietary guidelines emphasizing plant-based proteins. Read More

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http://dx.doi.org/10.3148/cjdpr-2020-016DOI Listing

Caregivers' Perceptions of Real-Food Containing Tube Feeding: A Canadian Survey.

Can J Diet Pract Res 2020 Jun 4:1-5. Epub 2020 Jun 4.

Medical Scientific Regulatory Unit, Nestlé Health Science, North York, ON.

Caregivers of children requiring tube feeding show growing interest in real-food containing formula, including home-blenderized tube feeding (HBTF) and commercial real-food containing formulas (CRFCF). This study aimed to understand caregivers' perceptions of both. Caregivers using real-food containing tube feeding were recruited through the Feeding Tube Awareness Foundation Facebook group. Read More

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http://dx.doi.org/10.3148/cjdpr-2020-012DOI Listing

Validity and Reproducibility of a Semi-Quantitative Food-Frequency Questionnaire Designed to Measure the Nutrient Intakes of Canadian South Asian Infants at 12 Months of Age.

Can J Diet Pract Res 2020 Jun 4:1-9. Epub 2020 Jun 4.

Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON.

Validated methods to assess diet of non-European infants are sparse. We assessed the validity and reliability of a semi-quantitative food-frequency questionnaire (FFQ) for South Asian infants in Canada. We developed an 80-item FFQ to assess infant nutrient intake in the South Asian Birth Cohort study (START). Read More

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http://dx.doi.org/10.3148/cjdpr-2020-011DOI Listing

Do Medical Students Receive Adequate Otolaryngology Training? A Canadian Perspective.

Ann Otol Rhinol Laryngol 2020 Jun 4:3489420932593. Epub 2020 Jun 4.

Dalhousie Medicine New Brunswick, Saint John, NB, Canada.

Objectives: Otolaryngology-head and neck surgery (OHNS) training has been found to be underrepresented in medical school curricula. The study aimed to assess (i) students' clinical OHNS exposure, (ii) their confidence managing OHNS conditions, and (iii) the correlation between OHNS exposure and confidence managing OHNS conditions.

Methods: Fourth-year medical students at two Canadian Universities completed a survey assessing baseline characteristics, OHNS training, and confidence managing OHNS conditions. Read More

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http://dx.doi.org/10.1177/0003489420932593DOI Listing

Quality of telephone-based cancer symptom management by nurses: a quality improvement project.

Support Care Cancer 2020 Jun 4. Epub 2020 Jun 4.

Cancer Care Ontario, Toronto, Ontario, Canada.

Purpose: To determine the quality of cancer symptom management when evidence from clinical practice guidelines are used in telephone-based oncology nursing services.

Methods: Guided by the Knowledge to Action Framework, we conducted a quality improvement (QI) project focused on "monitoring knowledge use" (e.g. Read More

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http://dx.doi.org/10.1007/s00520-020-05551-5DOI Listing

Health-care Workforce Training to Effectively Support Family Caregivers of Seniors in Care.

Can Geriatr J 2020 Jun 1;23(2):160-171. Epub 2020 May 1.

Department of Occupational Therapy, University of Alberta, Edmonton, AB, Canada.

Introduction: Family caregivers (FCGs) play an integral, yet often invisible, role in the Canadian health-care system. As the population ages, their presence will become even more essential as they help balance demands on the system and enable community-dwelling seniors to remain so for as long as possible. To preserve their own well-being and capacity to provide ongoing care, FCGs require support to the meet the challenges of their daily caregiving responsibilities. Read More

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http://dx.doi.org/10.5770/cgj.23.384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259919PMC

Using Expert Consensus to Develop a Tool to Assess Physical Therapists' Knowledge, Skills, and Judgement in Performing Airway Suctioning.

Physiother Can 2020 ;72(2):137-146

Department of Physical Therapy, University of Toronto, Toronto.

The aim of this study was to develop a tool to assess physical therapists' knowledge, skills, and judgement in performing airway suctioning with intubated and non-intubated adults. A modified Delphi methodology was used to develop the tool and to evaluate its sensibility (i.e. Read More

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http://dx.doi.org/10.3138/ptc-2018-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238934PMC
January 2020

Towards non-invasive computational-mechanics and imaging-based diagnostic framework for personalized cardiology for coarctation.

Sci Rep 2020 Jun 3;10(1):9048. Epub 2020 Jun 3.

Department of Mechanical Engineering, McMaster University, Hamilton, ON, Canada.

Coarctation of the aorta (COA) is a congenital narrowing of the proximal descending aorta. Although accurate and early diagnosis of COA hinges on blood flow quantification, proper diagnostic methods for COA are still lacking because fluid-dynamics methods that can be used for accurate flow quantification are not well developed yet. Most importantly, COA and the heart interact with each other and because the heart resides in a complex vascular network that imposes boundary conditions on its function, accurate diagnosis relies on quantifications of the global hemodynamics (heart-function metrics) as well as the local hemodynamics (detailed information of the blood flow dynamics in COA). Read More

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http://dx.doi.org/10.1038/s41598-020-65576-yDOI Listing

Sex differences after coronary artery bypass grafting with a second arterial conduit.

J Thorac Cardiovasc Surg 2020 Apr 23. Epub 2020 Apr 23.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada; Institute for Clinical Evaluative Sciences, Ottawa, Ontario, Canada; Division of Cardiac Anesthesiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Objectives: Double arterial conduit use during coronary artery bypass grafting is associated with improved clinical outcomes compared with single arterial conduits in the general population. However, the sex-specific outcomes of this strategy remain unknown and are needed to inform sex-specific revascularization guidelines.

Methods: We conducted a population-based, retrospective cohort study of all Ontarians who underwent primary isolated coronary artery bypass grafting with single arterial conduits or double arterial conduits between October 2008 and September 2017. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.04.058DOI Listing

A Canadian Cohort Study to Evaluate the Outcomes Associated with a Multicenter Initiative to Reduce Antipsychotic Use in Long-Term Care Homes.

J Am Med Dir Assoc 2020 May 31. Epub 2020 May 31.

Health Standards Organization, Ottawa, Ontario, Canada.

Objectives: To evaluate the impact of a multicenter intervention to reduce potentially inappropriate antipsychotic use in Canadian nursing homes at the individual and facility levels.

Design: Longitudinal, population-based cohort study to evaluate the Canadian Foundation for Healthcare Improvement's Spreading Healthcare Innovations Initiative to reduce potentially inappropriate antipsychotic use in 6 provinces/territories.

Setting And Participants: Adults in nursing homes in 6 provinces/territories in Canada between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.jamda.2020.04.004DOI Listing

Occupational Performance Outcome for Survivors of Childhood Cancer: Feasibility of the Canadian Occupational Performance Measure.

Occup Ther Health Care 2020 Jun 3:1-13. Epub 2020 Jun 3.

Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.

The aim of the study was to determine the feasibility of the Persian version of the Canadian Occupational Performance Measure (COPM) to assess self-reported occupational performance in a group of children with cancer at least one-year post-cancer diagnosis and intervention and to describe the self-reported occupational performance problems of children with cancer. Forty-three children with cancer (mean age 11.59 years; SD 4. Read More

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http://dx.doi.org/10.1080/07380577.2020.1773011DOI Listing

Documenting change with the Canadian Occupational Performance Measure for children with cerebral palsy.

Dev Med Child Neurol 2020 Jun 3. Epub 2020 Jun 3.

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Aim: To assess the Canadian Occupational Performance Measure's (COPM) ability to document change over 3 years in children with cerebral palsy (CP).

Method: This was a prospective study with ambulatory children with CP, aged 2 to 6 years. Caregivers set one to three COPM goals which were rescored annually over 3 years. Read More

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http://dx.doi.org/10.1111/dmcn.14569DOI Listing

Using concept mapping to explore the challenges associated with affording and accessing medications among people living with HIV in Ontario, Canada.

AIDS Care 2020 Jun 3:1-6. Epub 2020 Jun 3.

Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Antiretroviral medications are expensive, and people living with HIV often experience challenges accessing and paying for medication due to various obstacles. We used concept mapping to explore the challenges people living with HIV in Ontario, Canada, face when accessing medication. In brainstorming, 68 participants generated 447 statements in response to the focus prompt "Some people living with HIV have trouble getting and paying for prescription drugs because … ". Read More

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http://dx.doi.org/10.1080/09540121.2020.1770182DOI Listing

Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study.

Phys Chem Chem Phys 2020 Jun 3. Epub 2020 Jun 3.

Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.

Adenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods. Read More

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http://dx.doi.org/10.1039/d0cp00797hDOI Listing

Incidence and severity of Visually Induced motion Sickness during 3D laparoscopy In Operators who had No experience with it (VISION).

Wideochir Inne Tech Maloinwazyjne 2020 Jun 20;15(2):283-289. Epub 2020 Apr 20.

Department of Thoracic and Cardiovascular Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (South).

Aim: The aim of the study was to evaluate the incidence and severity of visually induced motion sickness (VIMS) during 3D laparoscopy, in operators without prior experience.

Material And Methods: Design: A retrospective comparative study (Canadian Task Force classification II-2). Setting: A university hospital. Read More

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http://dx.doi.org/10.5114/wiitm.2020.94347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233166PMC

The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity.

Ann Thorac Med 2020 Apr-Jun;15(2):70-75. Epub 2020 Apr 3.

Somnogen Canada Inc., Toronto, ON, Canada.

Objective: Currently accepted guidelines categorize obstructive sleep apnea (OSA) severity according to the Apnea-Hypopnea Index (AHI). However, it is unclear how to best define OSA severity. The present study sought to evaluate the concurrent validity of the widely accepted AHI by correlating it with various oxygen saturation (SpO) and polysomnographic parameters. Read More

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http://dx.doi.org/10.4103/atm.ATM_215_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259396PMC

Updates from the American Society of Hematology 2019 annual meeting: practice-changing studies in treatment-naïve chronic lymphocytic leukemia.

Curr Oncol 2020 Apr 1;27(2):e231-e245. Epub 2020 May 1.

McGill University Health Centre, Montreal, QC.

The 2019 annual meeting of the American Society of Hematology took place 7-10 December in Orlando, Florida. At the meeting, results from key studies in treatment-naïve chronic lymphocytic leukemia (cll) were presented. Of those studies, phase iii oral presentations focused on the efficacy and safety of therapy with inhibitors of Bruton tyrosine kinase (btk) and Bcl-2. Read More

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http://dx.doi.org/10.3747/co.27.6291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253738PMC

The Canadian Cancer Research Conference 2019.

Curr Oncol 2020 Apr 1;27(2):e226-e230. Epub 2020 May 1.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON.

The 5th Canadian Cancer Research Conference (ccrc) took place 3-5 November 2019 in Ottawa, Ontario. Nearly 1000 participants-scientists, oncologists, community members, and patients-gathered to share knowledge, foster collaboration, and fuel the future of cancer research in Canada. The scientific program included 3 plenary sessions, 26 concurrent sessions, and 2 poster sessions presenting research described in more than 600 submitted abstracts, giving participants the opportunity to share health research that collectively encompassed the 4 pillars recognized by the Canadian Institutes of Health Research. Read More

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http://dx.doi.org/10.3747/co.27.6245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253731PMC

A population-based analysis of breast cancer incidence and survival by subtype in Ontario women.

Curr Oncol 2020 Apr 1;27(2):e191-e198. Epub 2020 May 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON.

Background: Breast cancer (bca) is the type of cancer most frequently diagnosed among women in Canada. Breast cancer is categorized into various molecular subtypes by the expression of estrogen receptor (er), progesterone receptor (pgr), and her2 (human epidermal growth factor receptor 2). Currently, Canada has no national cancer registry with epidemiology data by subtype. Read More

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http://dx.doi.org/10.3747/co.27.5769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253754PMC

Germline variants and phenotypic spectrum in a Canadian cohort of individuals with diffuse gastric cancer.

Curr Oncol 2020 Apr 1;27(2):e182-e190. Epub 2020 May 1.

Sinai Health System, Department of Surgery, University of Toronto, Toronto, ON.

Background: pathogenic variants (pvs) cause most cases of inherited diffuse gastric cancer (dgc), but have low detection rates and vary geographically. In the present study, we examined hereditary causes of dgc in patients in Ontario.

Methods: testing through single-site or multi-gene panels was conducted for patients with dgc meeting the 2015 International Gastric Cancer Linkage Consortium (igclc) criteria, or with isolated dgc at less than 50 years of age, or with a strong family history of cancer identified at the Zane Cohen Centre (zcc). Read More

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http://dx.doi.org/10.3747/co.27.5663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253747PMC

Translating guidelines to practice: a training session about cancer-related fatigue.

Curr Oncol 2020 Apr 1;27(2):e163-e170. Epub 2020 May 1.

School of Psychology, University of Ottawa, Ottawa, ON.

Background: Cancer-related fatigue (crf) is the highest unmet need in cancer survivors. The Canadian Association of Psychosocial Oncology (capo) has developed guidelines for screening, assessment, and intervention in crf; however, those guidelines are not consistently applied in practice because of patient, health care provider (hcp), and systemic barriers. Notably, previous studies have identified a lack of knowledge of crf guidelines as an impediment to implementation. Read More

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http://dx.doi.org/10.3747/co.27.5681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253734PMC

Canadian consensus: a new systemic treatment algorithm for advanced mutated non-small-cell lung cancer.

Curr Oncol 2020 Apr 1;27(2):e146-e155. Epub 2020 May 1.

William Osler Health System, University of Toronto, Brampton, ON.

Background: Multiple clinical trials for the treatment of advanced mutated non-small-cell lung cancer (nsclc) have recently been reported. As a result, the treatment algorithm has changed, and many important clinical questions have been raised:■ What is the optimal first-line treatment for patients with mutated nsclc?■ What is preferred first-line treatment for patients with brain metastasis?■ What is the preferred second-line treatment for patients who received first-line first- or second-generation tyrosine kinase inhibitors (tkis)?■ What is the preferred treatment after osimertinib?■ What evidence do we have for treating patients whose tumours harbour uncommon mutations?

Methods: A Canadian expert panel was convened to define the key clinical questions, review recent evidence, and discuss and agree on practice recommendations for the treatment of advanced mutated nsclc.

Results: The published overall survival results for osimertinib, combined with its central nervous system activity, have led to osimertinib becoming the preferred first-line treatment for patients with common mutations, including those with brain metastasis. Read More

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http://dx.doi.org/10.3747/co.27.6007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253730PMC

Nonsurgical management of advanced hepatocellular carcinoma: a clinical practice guideline.

Curr Oncol 2020 Apr 1;27(2):e106-e114. Epub 2020 May 1.

Princess Margaret Cancer Centre, Toronto, ON.

Background: Practice guidelines based on a systematic review of the literature regarding the nonsurgical management of hepatocellular carcinoma (hcc) in North America are lacking. Resection and transplantation are the foundations for cure of hcc; however, most patients are diagnosed at an advanced stage, precluding those curative treatments. A number of local or regional therapies are used and are followed by systemic therapy for advanced or progressive disease. Read More

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http://dx.doi.org/10.3747/co.27.5891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253733PMC

Update on the subcutaneous administration of rituximab in Canadian cancer centres.

Curr Oncol 2020 Apr 1;27(2):113-116. Epub 2020 May 1.

Hoffmann-La Roche, Mississauga, ON.

Results of studies comparing subcutaneous (sc) with intravenous (iv) rituximab indicate that the two formulations are comparable in efficacy, but most patients and health care professionals prefer the sc route, commonly because of shorter chair time and reduced risk of infusion-related reactions. Recent Canadian data, including those from the scuba study reported here, support the results of earlier international studies showing a reduction in preparation and administration time with the sc formulation, lower cost of administration, and reduced drug wastage because of the fixed sc dosing. Given the significant time and cost savings of the sc formulation, that formulation is generally preferred over the iv formulation for the treatment of follicular lymphoma, diffuse large B cell lymphoma, and chronic lymphocytic leukemia. Read More

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http://dx.doi.org/10.3747/co.27.6041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253745PMC

Radiotherapy side effects: integrating a survivorship clinical lens to better serve patients.

Curr Oncol 2020 Apr 1;27(2):107-112. Epub 2020 May 1.

Department of Oncology, Division of Radiation Oncology, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC.

The Canadian Cancer Society estimated that 220,400 new cases of cancer would be diagnosed in 2019. Of the affected patients, more than 60% will survive for 5 years or longer after their cancer diagnosis. Furthermore, nearly 40% will receive at least 1 course of radiotherapy (rt). Read More

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http://dx.doi.org/10.3747/co.27.6233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253739PMC

A catalyst for transforming health systems and person-centred care: Canadian national position statement on patient-reported outcomes.

Curr Oncol 2020 Apr 1;27(2):90-99. Epub 2020 May 1.

Alberta: Department of Oncology, University of Calgary, Calgary (Barbera, Bebb, Cheung); University of Calgary, Calgary (Crump, Temple); Departments of Surgery and Oncology, University of Calgary, Calgary (McKinnon); Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary (Pink, Santana); University of Calgary and Tom Baker Cancer Centre, Calgary (Robinson); Faculty of Nursing, University of Calgary, Calgary (Sinclair).

Background: Patient-reported outcomes (pros) are essential to capture the patient's perspective and to influence care. Although pros and pro measures are known to have many important benefits, they are not consistently being used and there is there no Canadian pros oversight. The Position Statement presented here is the first step toward supporting the implementation of pros in the Canadian health care setting. Read More

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http://dx.doi.org/10.3747/co.27.6399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253746PMC

Impact of COVID-19 on Canadian medical oncologists and cancer care: Canadian Association of Medical Oncologists survey report.

Curr Oncol 2020 04 1;27(2):71-74. Epub 2020 May 1.

Dalhousie University, Halifax, NS.

Background: The covid-19 pandemic has presented unprecedented professional and personal challenges for the oncology community. Under the auspices of the Canadian Association of Medical Oncologists, we conducted an online national survey to better understand the impact of the pandemic on the medical oncology community in Canada.

Methods: An English-language multiple-choice survey, including questions about demographics, covid-19 risk, use of personal protective equipment (ppe), personal challenges, and chemotherapy management was distributed to Canadian medical oncologists. Read More

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http://dx.doi.org/10.3747/co.27.6643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253737PMC

Policymaker and stakeholder perspectives on access to assistive technologies in Canada: challenges and proposed solutions for enhancing equitable access.

Disabil Rehabil Assist Technol 2020 Jun 3:1-13. Epub 2020 Jun 3.

McMaster Health Forum, McMaster University, Hamilton, Canada.

Unmet needs for assistive technologies (ATs) exist and the need for ATs is growing owing to demographic changes worldwide. Little comprehensive research has examined equity of access to ATs in Canada. Our study elucidates perspectives of policymakers and stakeholders on challenges and solutions for enhancing equitable access to ATs to advance policy discussions. Read More

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http://dx.doi.org/10.1080/17483107.2020.1765033DOI Listing

Implementation of an in-patient hip fracture liaison services to improve initiation of osteoporosis medication use within 1-year of hip fracture: a population-based time series analysis using the RE-AIM framework.

Arch Osteoporos 2020 Jun 2;15(1):83. Epub 2020 Jun 2.

University of Alberta (Medicine), Edmonton, AB, Canada.

A hip fracture liaison service that was implemented in 2 hospitals in Alberta, Canada, co-managed by a nurse and physician, was effective for improving initiation of osteoporosis medication following hip fracture.

Purpose: To examine implementation of an in-patient hip fracture liaison service (H-FLS) to improve osteoporosis medication use after hip fracture using the RE-AIM framework (reach, effectiveness, adoption, implementation, maintenance).

Methods: Using population-based administrative data from 7 quarters before and up to 7 quarters after H-FLS implementation, we examined new starts, continued use, and overall use (new starts + continued use) of osteoporosis medication after hip fracture. Read More

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http://dx.doi.org/10.1007/s11657-020-00751-2DOI Listing

Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.

Sci Rep 2020 Jun 2;10(1):8982. Epub 2020 Jun 2.

Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, H1T 2M4, Canada.

The binder of sperm family of proteins has been reported to be indispensable for sperm maturation and capacitation. However, their physiological functions in fertility have only been studied in vitro. CRISPR/Cas9 genome editing was utilized to generate double knockout (DKO) mice by simultaneously targeting the two murine binder of sperm genes, Bsph1 and Bsph2. Read More

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http://dx.doi.org/10.1038/s41598-020-66017-6DOI Listing

Fine-tuning of Genome-Wide Polygenic Risk Scores and Prediction of Gestational Diabetes in South Asian Women.

Sci Rep 2020 Jun 2;10(1):8941. Epub 2020 Jun 2.

Department of Medicine, McMaster University Hamilton, Ontario, Canada.

Gestational diabetes Mellitus (GDM) affects 1 in 7 births and is associated with numerous adverse health outcomes for both mother and child. GDM is suspected to share a large common genetic background with type 2 diabetes (T2D). The aim of our study was to characterize different GDM polygenic risk scores (PRSs) and test their association with GDM using data from the South Asian Birth Cohort (START). Read More

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http://dx.doi.org/10.1038/s41598-020-65360-yDOI Listing

Protocol for a mixed-method analysis of implementation of case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs.

BMJ Open 2020 Jun 1;10(6):e038241. Epub 2020 Jun 1.

Department of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Introduction: Case management (CM) in a primary care setting is a promising approach to integrating and improving healthcare services and outcomes for patients with chronic conditions and complex care needs who frequently use healthcare services. Despite evidence supporting CM and interest in implementing it in Canada, little is known about how to do this. This research aims to identify the barriers and facilitators to the implementation of a CM intervention in different primary care contexts (objective 1) and to explain the influence of the clinical context on the degree of implementation (objective 2) and on the outcomes of the intervention (objective 3). Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038241DOI Listing

Medial temporal lobe cortical changes in response to exercise interventions in people with early psychosis: A randomized controlled trial.

Schizophr Res 2020 May 30. Epub 2020 May 30.

Department of Radiology, University of British Columbia, Canada. Electronic address:

Objective: Individuals with early psychosis may have prefrontal-limbic cortical deficits, which are associated with symptom severity and cognitive impairment. This study investigated the impact of an exercise intervention on fronto-temporal cortical plasticity in female participants with early psychosis.

Methods: In a cohort of 51 female participants with early psychosis from Hong Kong, we investigated the effects of a 12-week, moderate intensity aerobic or Hatha yoga exercise trial (yoga (N = 21), aerobic (N = 18) or waitlist group (N = 12)) on cortical grey matter. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.043DOI Listing

"If you do not find the world tasty and sexy, you are out of touch with the most important things in life": Resident and family member perspectives on sexual expression in continuing care.

J Aging Stud 2020 Jun 7;53:100849. Epub 2020 May 7.

Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada. Electronic address:

Over the past three decades, there has been growing attention to sexual expression in continuing care homes. However, resident perspectives continue to be underrepresented, particularly in the Canadian context. In this article, we share findings from a qualitative, exploratory study looking at the experiences of residents and family members in Alberta, Canada. Read More

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http://dx.doi.org/10.1016/j.jaging.2020.100849DOI Listing

The burden of familial chylomicronemia syndrome in Canadian patients.

Lipids Health Dis 2020 Jun 2;19(1):120. Epub 2020 Jun 2.

Lipids, Nutrition and Cardiovascular Prevention Clinic, Montreal Clinical Research Institute, 110 Avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.

Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder characterized by persistent extreme hypertriglyceridemia as a result of lipoprotein lipase deficiency. Canada is an important region for FCS research due to the high prevalence rates. The burden of illness and quality of life of Canadian patients, however, have been inadequately addressed in the literature. Read More

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http://dx.doi.org/10.1186/s12944-020-01302-xDOI Listing

A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol.

BMC Psychiatry 2020 Jun 2;20(1):268. Epub 2020 Jun 2.

The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada.

Background: Recent evidence underscores the utility of rapid-acting antidepressant interventions, such as ketamine, in alleviating symptoms of major depressive episodes (MDE). However, to date, there have been limited head-to-head comparisons of intravenous (IV) ketamine infusions with other antidepressant treatment strategies in large randomized trials. This study protocol describes an ongoing multi-centre, prospective, randomized, crossover, non-inferiority trial comparing acute treatment of individuals meeting diagnostic criteria for a major depressive episode (MDE) with ketamine and electroconvulsive therapy (ECT) on efficacy, speed of therapeutic effects, side effects, and health care resource utilization. Read More

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http://dx.doi.org/10.1186/s12888-020-02672-3DOI Listing

Effectiveness of psychotherapeutic interventions on psychological distress in women who have experienced perinatal loss: a systematic review protocol.

Syst Rev 2020 Jun 2;9(1):125. Epub 2020 Jun 2.

Faculty of Nursing, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta, T2N 1 N4, Canada.

Background: Perinatal loss is a traumatic and complex experience that contributes to negative maternal psychological states and adverse outcomes impacting fetal development, maternal-fetal/infant bonding, marital/partner relationships, and child cognitive, emotional, and behavioral development. These outcomes present preventable disease burden and financial liability to individuals, families, and the healthcare system. Psychological interventions have the potential to improve outcomes for women and their families after perinatal loss. Read More

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http://dx.doi.org/10.1186/s13643-020-01387-6DOI Listing