127,614 results match your criteria Canadian Journal Of Anesthesia-journal Canadien D Anesthesie[Journal]


Which Factors Contribute to Frailty among the Oldest Old? Results of the Multicentre Prospective AgeCoDe and AgeQualiDe Study.

Gerontology 2020 Jul 7:1-7. Epub 2020 Jul 7.

Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: There is a lack of studies investigating the link between time-varying factors associated with changes in frailty scores in very old age longitudinally. This is important because the level of frailty is associated with subsequent morbidity and mortality.

Objective: To examine time-dependent predictors of frailty among the oldest old using a longitudinal approach. Read More

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http://dx.doi.org/10.1159/000508723DOI Listing

Inflammatory bowel disease nurses' perspectives: Prioritizing adolescent transition readiness factors.

J Pediatr Nurs 2020 Jul 4;55:29-39. Epub 2020 Jul 4.

Education & Music Library, University of Saskatchewan, 28 Campus Drive, Room 2003.7A Education Bldg., Saskatoon, SK S7N 0X1, Canada. Electronic address:

Purpose: Despite the wealth of knowledge and expertise that Inflammatory Bowel Disease (IBD) nurses bring to the transition process, health literature lacks nurses' perspectives on transition readiness. The purpose of study was to ask IBD nurses to prioritize care transition readiness factors for adolescents living with IBD.

Design And Methods: The cross-sectional exploratory survey was researcher-developed and distributed online to IBD nurses across Canada. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.011DOI Listing

Formal and informal care received by middle-aged and older adults with chronic conditions in Canada: CLSA data.

PLoS One 2020 7;15(7):e0235774. Epub 2020 Jul 7.

Centre for Health Evaluation and Outcome Sciences, Vancouver, British Columbia, Canada.

Background: Middle-aged and older adults are more likely to suffer from chronic conditions, which can increase their need for both formal and informal care. This study seeks to assess and compare the extent to which the use of formal and informal care is attributed to different chronic conditions among middle-aged and older women and men in Canada.

Methods: We used baseline data from the Canadian Longitudinal Study on Aging (CLSA). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235774PLOS

Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing.

Transfusion 2020 Jul 6. Epub 2020 Jul 6.

Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada.

Treatment of red blood cells with dithiothreitol (DTT) or trypsin effectively denatures CD38; however, this treatment damages other antigens, some of which are of clinical importance. Thus, other avenues to deplete daratumumab (DARA) from plasma samples should be explored.

Study Design And Methods: The Daudi B-cell line was found to express high levels of CD38 and was sonicated in a sonication buffer to achieve complete cell lysis. Read More

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http://dx.doi.org/10.1111/trf.15932DOI Listing

Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC).

J Neurooncol 2020 Jul 7. Epub 2020 Jul 7.

Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.

Background: Diffuse intrinsic pontine gliomas (DIPG) are midline gliomas that arise from the pons and the majority are lethal within a few months after diagnosis. Due to the lack of histological diagnosis the epidemiology of DIPG is not completely understood. The aim of this report is to provide population-based data to characterize the descriptive epidemiology of this condition in Canadian children. Read More

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http://dx.doi.org/10.1007/s11060-020-03568-8DOI Listing

Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients.

J Neurooncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G2M9, Canada.

Introduction: Tumor-related epilepsy may respond to chemotherapy. In a previously-published multi-centre randomized clinical trial of 562 elderly glioblastoma patients, temozolomide plus short-course radiotherapy conferred a survival benefit over radiotherapy alone. Seizure outcomes were not reported. Read More

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http://dx.doi.org/10.1007/s11060-020-03573-xDOI Listing

Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes.

AMB Express 2020 Jul 6;10(1):120. Epub 2020 Jul 6.

Oral Ecology Research Group, Faculty of Dentistry, Université Laval, 2420 de la Terrasse, Quebec City, QC, G1V 0A6, Canada.

Enterococcus faecalis is one of the bacterial species most frequently isolated from persistent endodontic and apical periodontal infections. The aim of the present study was to evaluate the synergistic antibacterial effects of nisin and selected licorice polyphenols (glabridin, licoricidin, licochalcone A) against planktonic and biofilm-embedded E. faecalis cells. Read More

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http://dx.doi.org/10.1186/s13568-020-01056-wDOI Listing

Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung.

MAGMA 2020 Jul 6. Epub 2020 Jul 6.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.

Objective: Diffusion-weighted, hyperpolarized Xe MRI is useful for the characterization of microstructural changes in the lung. A stretched exponential model was proposed for morphometric extraction of the mean chord length (L) from diffusion-weighted data. The stretched exponential model enables accelerated mapping of L in a single-breathhold using compressed sensing. Read More

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http://dx.doi.org/10.1007/s10334-020-00860-6DOI Listing

Identification and characterization of Colletotrichum species causing apple bitter rot in New York and description of C. noveboracense sp. nov.

Sci Rep 2020 Jul 6;10(1):11043. Epub 2020 Jul 6.

Cornell University, Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Hudson Valley Research Laboratory, Highland, NY, USA.

Apple bitter rot caused by Colletotrichum species is a growing problem worldwide. Colletotrichum spp. are economically important but taxonomically un-resolved. Read More

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http://dx.doi.org/10.1038/s41598-020-66761-9DOI Listing

Atypical age-related changes in cortical thickness in autism spectrum disorder.

Sci Rep 2020 Jul 6;10(1):11067. Epub 2020 Jul 6.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Dr, Burnaby, BC, V5A 1S6, Canada.

Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (ASD). It is not clear, however, which aspects of age-related changes (trajectories) would be optimal for identifying atypical brain development in ASD. Using a large cross-sectional data set (Autism Brain Imaging Data Exchange [ABIDE] repository; releases I and II), we aimed to explore age-related changes in cortical thickness (CT) in TD and ASD populations (age range 6-30 years old). Read More

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http://dx.doi.org/10.1038/s41598-020-67507-3DOI Listing

Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.

CMAJ 2020 Jul;192(27):E768-E777

Department of Community Health Sciences (Groulx), University of Sherbrooke, Sherbrooke, Que.; Public Health Agency of Canada (Limburg, Doull), Ottawa, Ont.; Department of Medicine (Klarenbach), University of Alberta, Edmonton, Alta.; Internal Medicine and Community Health Sciences (Singh), University of Manitoba, Winnipeg, Man.; Community Health and Humanities (Wilson), Memorial University, St. John's, Nfld.; Department of Psychiatry (Thombs), Jewish General Hospital and McGill University, Montréal, Que.

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http://dx.doi.org/10.1503/cmaj.190814DOI Listing

Relationship between motoric cognitive risk syndrome, cardiovascular risk factors and diseases, and incident cognitive impairment: Results from the "NuAge" study.

Maturitas 2020 Aug 16;138:51-57. Epub 2020 May 16.

Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland.

Background: Motoric Cognitive Risk syndrome (MCR), which combines Subjective Cognitive Complaint (SCC) and slow gait speed in individuals free of dementia and gait disability, is associated with cardiovascular risk factors and diseases as well as incident cognitive impairment. Little information on MCR exists in the Canadian population. This study aims to examine these associations in community-dwelling elderly people living in Quebec, which is a Canadian province. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.007DOI Listing

Chinese- and English-speaking adult current smokers' perspectives on smoking and culturally and linguistically appropriate cessation: a qualitative analysis.

Addict Sci Clin Pract 2020 Jul 6;15(1):23. Epub 2020 Jul 6.

UBC, Faculty of Medicine, Respiratory Medicine Division, Centre for Clinical Epidemiology and Evaluation (C2E2), Vancouver General Hospital - Research Pavilion, 716-828 West 10th Ave, Vancouver, BC, V5Z 1M9, Canada.

Background: A lack of culturally and linguistically appropriate smoking cessation intervention programs exist among Chinese-Canadian communities. Smoking cessation programs that are provided in Canadian mainstream culture and language have shown limited effectiveness in altering smoking behaviours of smokers from these communities. Our study aimed to explore and compare smoking patterns, knowledge, beliefs, and risk perceptions of adult current smokers between Chinese- and English-speaking Canadians participating in a culturally and linguistically tailored smoking cessation program. Read More

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http://dx.doi.org/10.1186/s13722-020-00197-4DOI Listing

Global health activists' lessons on building social movements for Health for All.

Int J Equity Health 2020 Jul 6;19(1):116. Epub 2020 Jul 6.

School of Public Health, University of the Western Cape, Cape Town, South Africa.

Background: The People's Health Movement (PHM) was formed in 2000 and drew inspiration from the Alma Ata Declaration on Primary Health Care's 'Health for All' (1978). Since then PHM has been an active part of a global counter-hegemonic social movement. This study aimed to gain insights on social movement building, drawing on the successes and failures reported by activists over their experiences of working in the Health for All social movement to improve health, justice and equity. Read More

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http://dx.doi.org/10.1186/s12939-020-01232-1DOI Listing

Street masking: a network-based geographic mask for easily protecting geoprivacy.

Int J Health Geogr 2020 Jul 6;19(1):26. Epub 2020 Jul 6.

Department of Pediatrics, School of Population and Public Health, University of British Columbia, British Columbia Injury Research and Prevention Unit, British Columbia Children's Hospital Research Institute, F511-4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.

Background: Geographic masks are techniques used to protect individual privacy in published maps but are highly under-utilized in research. This leads to continual violations of individual privacy, as sensitive health records are put at risk in unmasked maps. New approaches to geographic masking are required that foster accessibility and ease of use, such that they become more widely adopted. Read More

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http://dx.doi.org/10.1186/s12942-020-00219-zDOI Listing

Impact of the COVID-19 virus outbreak on movement and play behaviours of Canadian children and youth: a national survey.

Int J Behav Nutr Phys Act 2020 Jul 6;17(1):85. Epub 2020 Jul 6.

Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.

Background: Healthy childhood development is fostered through sufficient physical activity (PA; including time outdoors), limiting sedentary behaviours (SB), and adequate sleep; collectively known as movement behaviours. Though the COVID-19 virus outbreak has changed the daily lives of children and youth, it is unknown to what extent related restrictions may compromise the ability to play and meet movement behaviour recommendations. This secondary data analysis examined the immediate impacts of COVID-19 restrictions on movement and play behaviours in children and youth. Read More

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http://dx.doi.org/10.1186/s12966-020-00987-8DOI Listing

Epidemiology of drug driving: protocol from a national Canadian study measuring levels of cannabis, alcohol and other substances in injured drivers.

BMC Public Health 2020 Jul 6;20(1):1070. Epub 2020 Jul 6.

Department of Emergency Medicine, Faculty of Medicine, The University of British Columbia, 828 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada.

Background: Drug driving is an emerging global road safety problem. As the prevalence of alcohol-impaired driving decreases, and as more jurisdictions decriminalize or legalize cannabis, it is increasingly important for policy makers to have accurate information on the prevalence and pattern of drug driving. Unfortunately, this data is not widely available and the World Health Organization identifies lack of accurate data on the prevalence of drug driving as an important knowledge gap. Read More

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http://dx.doi.org/10.1186/s12889-020-09176-5DOI Listing

Patterns of fish and whale consumption in relation to methylmercury in hair among residents of Western Canadian Arctic communities.

BMC Public Health 2020 Jul 6;20(1):1073. Epub 2020 Jul 6.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Background: Methylmercury contamination of the environment represents a substantial environmental health concern. Human exposure to methylmercury occurs primarily through consumption of fish and marine mammals. Heavily exposed subgroups include sport or subsistence fishers residing in Arctic communities. Read More

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http://dx.doi.org/10.1186/s12889-020-09133-2DOI Listing

Canadian Public Safety Personnel and Occupational Stressors: How PSP Interpret Stressors on Duty.

Int J Environ Res Public Health 2020 Jul 1;17(13). Epub 2020 Jul 1.

Department of Sociology, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.

Canadian public safety personnel (e.g., correctional workers, firefighters) experience potential stressors as a function of their occupation. Read More

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http://dx.doi.org/10.3390/ijerph17134736DOI Listing

Effects of the COVID-19 pandemic on supply and use of blood for transfusion.

Lancet Haematol 2020 Jul 3. Epub 2020 Jul 3.

Manchester University NHS Foundation Trust, Manchester, UK.

The COVID-19 pandemic has major implications for blood transfusion. There are uncertain patterns of demand, and transfusion institutions need to plan for reductions in donations and loss of crucial staff because of sickness and public health restrictions. We systematically searched for relevant studies addressing the transfusion chain-from donor, through collection and processing, to patients-to provide a synthesis of the published literature and guidance during times of potential or actual shortage. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30186-1DOI Listing

Knock-out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post-myocardial infarction.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Toronto General Research Institute, University Health Network, Toronto, ON, Canada.

Prevention of infarct scar thinning and dilatation and stimulation of scar contracture can prevent progressive heart failure. Since microRNA 145 (miR-145) plays an important role in cardiac fibroblast response to wound healing and cardiac repair after an myocardial infarction (MI), using a miR-145 knock-out (KO) mouse model, we evaluated contribution of down-regulation of miR-145 to cardiac fibroblast and myofibroblast function during adverse cardiac remodelling. Cardiac function decreased more and the infarct size was larger in miR-145 KO than that in WT mice after MI and this phenomenon was accompanied by a decrease in cardiac fibroblast-to-myofibroblast differentiation. Read More

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http://dx.doi.org/10.1111/jcmm.15597DOI Listing

Is mammography screening beneficial: An individual-based stochastic model for breast cancer incidence and mortality.

PLoS Comput Biol 2020 Jul 6;16(7):e1008036. Epub 2020 Jul 6.

Department of Mathematics, University of Utah, Salt Lake City, Utah, United States of America.

The benefits of mammography screening have been controversial, with conflicting findings from various studies. We hypothesize that unmeasured heterogeneity in tumor aggressiveness underlies these conflicting results. Based on published data from the Canadian National Breast Screening Study (CNBSS), we develop and parameterize an individual-based mechanistic model for breast cancer incidence and mortality that tracks five stages of breast cancer progression and incorporates the effects of age on breast cancer incidence and all-cause mortality. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1008036DOI Listing

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.

PLoS Med 2020 Jul 6;17(7):e1003172. Epub 2020 Jul 6.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The "trimorbidity" of substance use disorder and mental and physical illness is associated with living in precarious housing or homelessness. The extent to which substance use increases risk of psychosis and both contribute to mortality needs investigation in longitudinal studies.

Methods And Findings: A community-based sample of 437 adults (330 men, mean [SD] age 40. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003172DOI Listing

Development of Best Practices of Peer Review for Lung Radiation Therapy.

JCO Oncol Pract 2020 Jul 6:OP2000066. Epub 2020 Jul 6.

Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario, Canada.

Purpose: Peer review (PR) is an important component in ensuring high-quality lung radiotherapy (RT) plans. However, there are inconsistencies in the extent, timing, and minimum requirements for PR. We sought to develop guidelines of best practices for PR in curative lung RT through an expert consensus process. Read More

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http://dx.doi.org/10.1200/OP.20.00066DOI Listing

Do Faba Bean Genotypes Carrying Different Zero-Tannin Genes ( and ) Differ in Phenolic Profiles?

J Agric Food Chem 2020 Jul 6. Epub 2020 Jul 6.

Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A8, Canada.

Faba bean is a cool season grain legume that produces seeds with a high protein content. Seed coat tannins limit its use in food and feed. A low-tannin phenotype is controlled by either of two unlinked recessive genes and . Read More

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http://dx.doi.org/10.1021/acs.jafc.9b07866DOI Listing

Anatomical and histological study of the alar fascia.

Clin Anat 2020 Jul 6. Epub 2020 Jul 6.

Department of Anatomical Sciences, St. George's University, Grenada, West Indies.

Introduction: The alar fascia remains one of the most variably described fascial structure in the human body. Much disagreement persists in the literature and mainstream anatomical texts about its anatomy, function, and clinical significance. It is generally described as a coronally-oriented fascial sheet separating the retropharyngeal space anteriorly from the danger space posteriorly. Read More

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http://dx.doi.org/10.1002/ca.23644DOI Listing

Comparing the Efficiency of Software-Based Speech Recognition Versus Traditional Telephone Transcription in an Outpatient Physical Medicine and Rehabilitation Practice.

Mil Med 2020 Jul 6. Epub 2020 Jul 6.

Alan Edwards Pain Management Unit, Canada.

Introduction: Speech recognition (SR) uses computerized word recognition software that automatically transcribes spoken words to written text. Some studies indicate that SR may improve efficiency of electronic charting as well as associated cost and turnaround time1,2, but it remains unclear in the literature whether SR is superior to traditional transcription (TT). This study compared the impact of report generation efficiency of SR to TT at the Canadian Armed Forces Health Services Centre. Read More

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http://dx.doi.org/10.1093/milmed/usz374DOI Listing

Macromolecular crystallography beamlines at the Canadian Light Source: building on success.

Acta Crystallogr D Struct Biol 2020 Jul 19;76(Pt 7):630-635. Epub 2020 Jun 19.

Canadian Macromolecular Crystallography Facility, Canadian Light Source, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada.

The Canadian Macromolecular Crystallography Facility (CMCF) consists of two beamlines dedicated to macromolecular crystallography: CMCF-ID and CMCF-BM. After the first experiments were conducted in 2006, the facility has seen a sharp increase in usage and has produced a significant amount of data for the Canadian crystallographic community. Upgrades aimed at increasing throughput and flux to support the next generation of more demanding experiments are currently under way or have recently been completed. Read More

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http://dx.doi.org/10.1107/S2059798320007603DOI Listing

Addressing embodied inequities in health: how do we enable improvement in women's diet in pregnancy?

Public Health Nutr 2020 Jul 6:1-11. Epub 2020 Jul 6.

Medical Research Council Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom of Great Britain and Northern Ireland.

Objective: To disrupt cycles of health inequity, traceable to dietary inequities in the earliest stages of life, public health interventions should target improving nutritional wellbeing in preconception/pregnancy environments. This requires a deep engagement with pregnant/postpartum people (PPP) and their communities (including their health and social care providers, HSCP). We sought to understand the factors that influence diet during pregnancy from the perspectives of PPP and HSCP, and to outline intervention priorities. Read More

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http://dx.doi.org/10.1017/S1368980020001093DOI Listing

COVID stress syndrome: Concept, structure, and correlates.

Depress Anxiety 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology, University of Regina, Regina, Saskatchewan, Canada.

Background: Research shows that the COVID Stress Scales have a robust multifactorial structure, representing five correlated facets of COVID-19-related distress: (a) Fear of the dangerousness of COVID-19, which includes fear of coming into contact with fomites potentially contaminated with SARSCoV2, (b) worry about socioeconomic costs of COVID-19 (e.g., worry about personal finances and disruption in the supply chain), (c) xenophobic fears that foreigners are spreading SARSCoV2, (d) traumatic stress symptoms associated with direct or vicarious traumatic exposure to COVID-19 (nightmares, intrusive thoughts, or images related to COVID-19), and (e) COVID-19-related compulsive checking and reassurance seeking. Read More

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http://dx.doi.org/10.1002/da.23071DOI Listing

Conducting fit-for-purpose food safety risk assessments.

EFSA J 2019 Jul 8;17(Suppl 1):e170707. Epub 2019 Jul 8.

Communication Engagement and Cooperation (COMCO) Department European Food Safety Authority (EFSA) Italy.

The interplay between science, risk assessment and risk management has always been complex, and even more so in a world increasingly characterised by rapid technical innovation, new modes of communication, suspicion about authorities and experts, and demands for people to have a say in decisions that are made on their behalf. In this challenging era where scientific advice on food safety has never been in greater demand, risk managers should effectively navigate the interplay between facts and values and be able to rely on robust and fit-for-purpose risk assessments to aid them. The fact that societal resistance is often encountered when scientific advice on food safety operates at a distance from social values and fails to actively engage with citizens, has led to increasing emphasis on the need to advance forms of risk assessment that are more contextual, and socially sound and accountable. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.e170707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015513PMC

Is a Long Non-coding RNA Locus That Regulates Expression.

Front Genet 2020 17;11:631. Epub 2020 Jun 17.

Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, ON, Canada.

Genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) most of them located in non-protein coding regions of the genome. One such locus is the CAD Associated Region between and (CARMA), a ∼18 kb haplotype that was recently shown to regulate vicinal protein coding genes. Here, we further investigate the region by examining a long non-coding RNA gene locus (RP11-326A19. Read More

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http://dx.doi.org/10.3389/fgene.2020.00631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311772PMC

An Unusual Enteritidis Strain Carrying a Modified Virulence Plasmid Lacking the Gene Represents a Geographically Widely Distributed Lineage.

Front Microbiol 2020 17;11:1322. Epub 2020 Jun 17.

Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, ON, Canada.

This study identifies a strain of subspecies serovar Enteritidis that harbors a highly unusual virulence plasmid. During the characterisation of a group of Enteritidis isolates, 10 isolates recovered from Canadian duck production facilities, of which seven were phage type 9b and three were closely related atypical phage types, failed detection by a PCR targeting the gene, a marker located on the virulence plasmid often employed for identification of this serovar. Comparison to + isolates by several standard genetic typing tools, further revealed their distinctive genomic makeup. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311658PMC

New data on the aphid (Hemiptera, Aphididae) fauna of New Caledonia: some new biosecurity threats in a biodiversity hotspot.

Zookeys 2020 22;943:53-89. Epub 2020 Jun 22.

Canadian National Collection of Insects, Agriculture and Agri-Food Canada/Agriculture et Agroalimentaire Canada Ottawa Research and Development Centre, K. W. Neatby Building 960 Carling Avenue, Ottawa, Ontario, K1a 0c6, Canada Agriculture and Agri-Food Canada/Agriculture et Agroalimentaire Canada Ottawa Research and Development Centre Ottawa Canada.

Thirty-three species of aphids are now established in New Caledonia. All species appear to have been introduced accidentally by human activity in the last century. Here, 17 aphid species are recorded for the first time: , , , , , , , , , , , , , , , , and . Read More

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http://dx.doi.org/10.3897/zookeys.943.47785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324436PMC

Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope.

Can J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada.

Syncope is a symptom that occurs in multiple settings and has a variety of underlying causes, ranging from benign to life threatening. Determining the underlying diagnosis and prognosis can be challenging and often results in an unstructured approach to evaluation, which is ineffective and costly. In this first ever document, the Canadian Cardiovascular Society (CCS) provides a clinical practice update on the assessment and management of syncope. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.023DOI Listing

A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

Transplant Proc 2020 Jul 2. Epub 2020 Jul 2.

Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada; Alberta Transplant Institute, Edmonton, AB, Canada; Canadian National Transplant Research Program, Edmonton, AB, Canada. Electronic address:

Background: Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate (CHIP) with equivalent functional and inflammatory characteristics to a standard Krebs-Henseleit buffer with 8% serum albumin-derived perfusate (KHB-Alb) to improve access and reduce costs of ex vivo organ perfusion.

Methods: Sixteen porcine lungs were perfused using negative pressure ventilation (NPV) EVLP for 12 hours in a normothermic state and were allocated equally to 2 groups: KHB-Alb vs CHIP. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.007DOI Listing

COVID-19 Pandemic: Perspective from Italian Pediatric Emergency Physicians.

Disaster Med Public Health Prep 2020 Jun 22:1-11. Epub 2020 Jun 22.

CRIMEDIM - Research Center in Emergency and Disaster Medicine, Università del Piemonte Orientale, Novara, Italy.

Objective: To document the lived experience of Italian pediatric emergency physicians during the COVID-19 pandemic.

Methods: We developed a structured interview to collect the lived experience of the staff of the Pediatric emergency department (PED) of a tertiary referral university hospital in Northern Italy. The open-ended questions were draft according to the suggestions of Canadian colleagues and administered by one interviewer, who was part of the PED staff, at the end of March 2020. Read More

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http://dx.doi.org/10.1017/dmp.2020.198DOI Listing

Prospective comparative evaluation of the European Society of Cardiology (ESC) 1-hour and a 2-hour rapid diagnostic algorithm for myocardial infarction using high-sensitivity troponin-T.

CJEM 2020 Jul 6:1-9. Epub 2020 Jul 6.

Department of Emergency Medicine.

Objective: Both 1- and 2-hour rapid diagnostic algorithms using high-sensitivity troponin (hs-cTn) have been validated to diagnose acute myocardial infarction (MI), leaving physicians uncertain which algorithm is preferable. The objective of this study was to prospectively evaluate the diagnostic performance of 1- and 2-hour algorithms in clinical practice in a Canadian emergency department (ED).

Methods: ED patients with chest pain had high-sensitivity cardiac troponin-T (hs-cTnT) collected on presentation and 1- and 2-hours later at a single academic centre over a 2-year period. Read More

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http://dx.doi.org/10.1017/cem.2020.349DOI Listing

Delta opioid receptor activation modulates affective pain and modality-specific pain hypersensitivity associated with chronic neuropathic pain.

J Neurosci Res 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology and Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models, including neuropathic pain, while having minimal effect on sensory thresholds in the absence of injury. The mechanisms underlying nerve injury-induced enhancement of DOR function are unclear. We used a peripheral nerve injury (PNI) model of neuropathic pain to assess changes in the function and localization of DORs in mice and rats. Read More

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http://dx.doi.org/10.1002/jnr.24680DOI Listing

Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.

Cardiovasc Drugs Ther 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose: Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annotation and functional studies.

Methods: Seventy ST cases on clopidogrel identified from the PLATO trial (n = 58) and Mayo Clinic biorepository (n = 12) were matched 1:1 with controls for age, race, sex, diabetes mellitus, presentation, and stent type. Read More

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http://dx.doi.org/10.1007/s10557-020-06988-wDOI Listing

The role of school characteristics in pre-legalization cannabis use change among Canadian youth: implications for policy and harm reduction.

Health Educ Res 2020 Jul 5. Epub 2020 Jul 5.

School of Public Health and Health Systems, University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, Canada.

Reducing youth cannabis use in Canada is a public health priority with schools of interest as a potential modifier of behavior and as a venue for prevention programming. This work aimed to provide a basis for future policy and programming by evaluating pre-legalization cannabis use change patterns in schools and the impact of school characteristics on these patterns. Average rates of cannabis use behavior change (initiation, escalation, reduction, cessation) were collected from 88 high schools located in Ontario and Alberta, Canada participating in the COMPASS prospective cohort study. Read More

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http://dx.doi.org/10.1093/her/cyaa018DOI Listing

Prevalence of abdominal obesity and associated lifestyle factors in bus drivers in a city in Southern Brazil.

Work 2020 Jun 27. Epub 2020 Jun 27.

Universidade Federal de Santa Catarina, Núcleo de Pesquisa em Cineantropometria e Desempenho Humano, Florianópolis, Santa Catarina, Brasil.

Background: Bus drivers are exposed to unique working conditions. However, the behavioral and health trends of these workers should be investigated.

Objective: To estimate the prevalence of abdominal obesity and associated lifestyle factors in bus drivers in a city in southern Brazil. Read More

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http://dx.doi.org/10.3233/WOR-203200DOI Listing

Effects of Probiotic Supplementation on Short Chain Fatty Acids in the AppNL-G-F Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2020 Jun 29. Epub 2020 Jun 29.

Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA.

Background: The intestinal microbiota and its metabolites, particularly short-chain fatty acids (SCFAs), have been implicated in immune function, host metabolism, and even behavior.

Objective: This study was performed to investigate whether probiotic administration influences levels of intestinal microbiota and their metabolites in a fashion that may attenuate brain changes in a mouse model of Alzheimer's disease (AD).

Methods: C57BL/6 wild-type (WT) mice were compared to AppNL-G-Fmice. Read More

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http://dx.doi.org/10.3233/JAD-200436DOI Listing

Recent Trends in Hospitalizations for Cardiovascular Disease, Stroke, and Vascular Cognitive Impairment in Canada.

Can J Cardiol 2020 Jun 18. Epub 2020 Jun 18.

Heart and Stroke Foundation of Canada, Toronto, Ontario, Canada. Electronic address:

Background: We analyzed hospitalization rates for a broad set of cardiovascular diseases, stroke, and vascular cognitive impairment (VCI) between 2007 and 2016 in Canada to characterize population-level trends and demographic and provincial/territorial variation in inpatient health care utilization.

Methods: Record-level administrative hospitalization data from April 1, 2007 to March 31, 2017 for individuals aged 0-105 years were obtained from the Canadian Institute for Health Information Discharge Abstract Database. Data were available for all provinces and territories, except Quebec. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.03.007DOI Listing

From Complexity to Consciousness.

Trends Neurosci 2020 Jun 24. Epub 2020 Jun 24.

Canadian Institute for Advanced Research, Azrieli Program in Brain, Mind, and Consciousness, Toronto, Canada; Department of Biomedical Clinical Sciences, University of Milan, Milan, Italy; IRCCS, Fondazione Don Gnocchi, Milan, Italy.

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http://dx.doi.org/10.1016/j.tins.2020.05.008DOI Listing

The impact of emergency department triage on the treatment outcomes of cancer patients with febrile neutropenia: A retrospective review.

Int Emerg Nurs 2020 Jul 1;51:100888. Epub 2020 Jul 1.

MUN School of Medicine, St. John's, Canada. Electronic address:

Introduction: The emergency department (ED) is an important entry point for patients with cancer requiring acute care due to oncological emergencies. Febrile neutropenia (FN) is one of the most common oncological emergencies and carries a significant risk of morbidity and mortality. There is evidence from previous studies that FN patients wait far longer in the ED than recommended by international guidelines. Read More

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http://dx.doi.org/10.1016/j.ienj.2020.100888DOI Listing

Association Between HbA Levels and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Cardiovascular Disease: A Secondary Analysis of the TECOS Randomized Clinical Trial.

Eur J Heart Fail 2020 Jul 4. Epub 2020 Jul 4.

Diabetes Trials Unit, University of Oxford, Oxford, UK.

Aims: Whether glycemic control is associated with cardiovascular outcomes in patients with type 2 diabetes (T2D) is unclear. Consequently, we assessed the relationship between glycated hemoglobin (HbA ) and cardiovascular outcomes in a placebo-controlled randomized trial which demonstrated no cardiovascular effect of sitagliptin in patients with T2D and atherosclerotic vascular disease.

Methods And Results: Secondary analysis of 14,656 TECOS participants with time to event analyses using multivariable Cox proportional hazard models. Read More

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http://dx.doi.org/10.1002/ejhf.1958DOI Listing

Diagnostic accuracy of cognitive screening tools under different neuropsychological definitions for poststroke cognitive impairment.

Brain Behav 2020 Jul 3:e01671. Epub 2020 Jul 3.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: The accuracy of cognitive screening tools to detect poststroke cognitive impairment (PSCI) was investigated using various neuropsychological definitions.

Methods: Hospital-based stroke patients underwent a comprehensive neuropsychological assessment. The rate of PSCI was estimated using thresholds of 1, 1. Read More

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http://dx.doi.org/10.1002/brb3.1671DOI Listing

Assessing New Zealand's Cannabis Legalization and Control Bill: prospects and challenges.

Addiction 2020 Jul 4. Epub 2020 Jul 4.

SHORE & Whariki Research Centre, Massey University, P.O. Box 6137, Victoria Street West, Auckland, 1142, New Zealand.

Background: Few countries have developed detailed legislative proposals for legalizing cannabis. New Zealand recently released the Cannabis Legalization and Control Bill (CLCB) that will be the subject of a referendum in September 2020.

Aims: To assess the CLCB, drawing on emerging evidence from cannabis legalization overseas, public health research on alcohol and tobacco and the attempt to establish a regulated market for 'legal highs' in New Zealand. Read More

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http://dx.doi.org/10.1111/add.15144DOI Listing

Review article: prognostic significance of body composition abnormalities in patients with cirrhosis.

Aliment Pharmacol Ther 2020 Jul 3. Epub 2020 Jul 3.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, AB, Canada.

Background: Recent advances in evaluation of body composition show body mass index to be inadequate in differentiating between body compartments in cirrhosis. Given the limitations of body mass index, body composition evaluation using computed tomography has been increasingly used as a non-invasive clinical tool with prognostic value. Another factor influencing prognosis includes sex-specific differences in body composition that are seen in cirrhosis. Read More

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http://dx.doi.org/10.1111/apt.15927DOI Listing