127,637 results match your criteria Canadian Geographer-geographe Canadien[Journal]


Moving Toward a Standardized National Family Medicine Subinternship Curriculum: Results From a CERA Clerkship Directors Survey.

Fam Med 2020 Jun;52(7):523-527

Department of Family Medicine, Saint Louis University School of Medicine, St Louis, MO.

Background And Objectives: Although the subinternship (sub-I) is considered integral in many medical schools' curricula, family medicine does not have standardized course recommendations. Given the variable nature of this clinical experience, this study investigated the potential role of a standardized sub-I curriculum in family medicine.

Methods: Questions about sub-Is were created and data were gathered and analyzed as part of the 2019 Council of Academic Family Medicine's (CAFM) Educational Research Alliance (CERA) survey of family medicine clerkship directors. Read More

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http://dx.doi.org/10.22454/FamMed.2020.209444DOI Listing

Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational Study.

Neonatology 2020 Jul 8:1-8. Epub 2020 Jul 8.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, Nova Scotia, Canada.

Background: Fentanyl is a commonly used off-label medication for pain control and sedation in preterm infants. Yet, the effect of fentanyl on cerebral hemodynamics in preterm neonates remains unexplored.

Objective: To evaluate the effect of a bolus dose of fentanyl on the regional cerebral oxygen saturation (RcSO2), cerebral fractional tissue oxygen extraction (cFTOE) and left ventricular output (LVO) as compared with pre-administration baseline in preterm infants. Read More

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http://dx.doi.org/10.1159/000508555DOI Listing

Pediatric Dyslipidemia-Beyond Familial Hypercholesterolemia.

Can J Cardiol 2020 Mar 23. Epub 2020 Mar 23.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address:

Dyslipidemia is seen with increasing prevalence in young Canadians, mainly mild to moderate hypertriglyceridemia secondary to obesity. This review focuses on pediatric dyslipidemias excluding familial hypercholesterolemia (FH), but including both severe and mild to moderate hypertriglyceridemia, combined hyperlipidemia, and elevated lipoprotein(a) [Lp(a)]. We suggest that for Canadian children and adolescents with dyslipidemia, atherosclerotic cardiovascular disease (ASCVD) risk assessment should include both low-density lipoprotein cholesterol and triglycerides measurement. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.03.020DOI Listing

The Possible Protective Effect of Colchicine against Liver Damage Induced by Renal Ischemia-Reperfusion Injury: Role of Nrf2 and NLRP3 inflammasome.

Can J Physiol Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Al-Azhar University, 68820, pharmacology and toxicology , nasr city-cairo , Cairo, Egypt ;

Background: Ischemia/reperfusion injury (IRI) induces an inflammatory response and production of ROS, which affects the organs remote to the sites of RIR. However, remote effects of RIR injury on the liver need further investigations. Renal injury associated with liver disease is a common clinical problem. Read More

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http://dx.doi.org/10.1139/cjpp-2020-0230DOI Listing

Time course of changes in the long latency feedback response parallels the fast process of short term motor adaptation.

J Neurophysiol 2020 Jul 8. Epub 2020 Jul 8.

Brain and Mind Institute, Dept. Psychology, The University of Western Ontario, Canada.

Adapting to novel dynamics involves modifying both feedforward and feedback control. We investigated whether the motor system alters feedback responses during adaptation to a novel force field in a manner similar to adjustments in feedforward control. We simultaneously tracked the time course of both feedforward and feedback systems via independent probes during a force field adaptation task. Read More

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http://dx.doi.org/10.1152/jn.00286.2020DOI Listing

Context, Types, and Consequences of Violence Across the Life Course: A Qualitative Study of the Lived Experiences of Transgender Women Living With HIV.

J Interpers Violence 2020 Jul 8:886260520935093. Epub 2020 Jul 8.

University of Michigan, Ann Arbor, USA.

Violence is a known driver of HIV vulnerability among transgender (trans) women, who are disproportionately impacted by HIV globally. Violence is also a barrier to accessing HIV prevention, treatment, and support. Yet, little is known about the everyday experiences of violence faced by trans women living with HIV, who live at the intersection of a marginalized gender identity and physical health condition. Read More

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http://dx.doi.org/10.1177/0886260520935093DOI Listing

International Survey on Determinants of Antibiotic Duration and Discontinuation in Pediatric Critically Ill Patients.

Pediatr Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

Objectives: We hypothesized that antibiotic use in PICUs is based on criteria not always supported by evidence. We aimed to describe determinants of empiric antibiotic use in PICUs in eight different countries.

Design: Cross-sectional survey. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002397DOI Listing

Postprandial zinc stable isotope response in human blood serum.

Metallomics 2020 Jul 8. Epub 2020 Jul 8.

Department of Geological Sciences and Geological Engineering, Queen's University, 36 Union Street, Kingston, K7L 2N8, Canada.

In recent years, considerable advances have been made in the field of medical isotope metallomics, but numerous fundamental physiological processes remain to be investigated. Past studies report that blood serum Zn concentrations decrease by between about 10 and 25%, depending on the size of meal, approximately three hours postprandially (i.e. Read More

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http://dx.doi.org/10.1039/d0mt00122hDOI Listing

An environmental scan of wellness initiatives and programs at Canadian academic emergency medicine programs: How far have we come?

CJEM 2020 Jun 23:1-7. Epub 2020 Jun 23.

Division of Emergency Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON.

Objectives: We sought to conduct a major objective of the Canadian Association of Emergency Physicians (CAEP) Wellness Committee, an environmental scan of the academic emergency medicine programs across the 17 Canadian medical schools.

Methods: An 89-question questionnaire was distributed to academic heads or wellness leads. The responses were verified by the lead author to ensure that the questions were answered completely and consistently. Read More

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http://dx.doi.org/10.1017/cem.2020.408DOI Listing

Fear of falling in community-dwelling older adults presenting to the emergency department for minor injuries: Impact on return to the ED and future falls.

CJEM 2020 Jun 24:1-9. Epub 2020 Jun 24.

Faculté de Médecine, Université Laval, Québec City, QC.

Objectives: 1) To characterize mild, moderate, and severe fear of falling in older emergency department (ED) patients for minor injuries, and 2) to assess whether fear of falling could predict falls and returns to the ED within 6 months of the initial ED visit.

Methods: This study was part of the Canadian Emergency and Trauma Initiative (CETI) prospective cohort (2011-2016). Patients ages ≥ 65, who were independent in their basic daily activities and who were discharged from the ED after consulting for a minor injury, were included. Read More

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http://dx.doi.org/10.1017/cem.2020.383DOI Listing

Pathways to gender affirmation in trans youth: A qualitative and participative study with youth and their parents.

Clin Child Psychol Psychiatry 2020 Jul 8:1359104520938427. Epub 2020 Jul 8.

Canada research Chair on transgender children and their families, UdM, Canada.

How trans youth realize about their gender identity and come out to their significant others is under-researched and very few studies include both youth and parental perspectives. This study was developed in Switzerland, a country where families with trans youth are just beginning to break invisibility. The research protocol draws on grounded theory methodology, is participative and developed in collaboration with a local trans NGO and a pan Canadian project. Read More

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http://dx.doi.org/10.1177/1359104520938427DOI Listing

Innovation processes for ageing-related health technologies.

Healthc Manage Forum 2020 Jul 8:840470420936715. Epub 2020 Jul 8.

University of Victoria, Victoria, British Columbia, Canada.

Innovative technologies offer potential benefits for the health and care needs of an ageing population, but the processes by which these innovations are developed and implemented are not well understood. As part of a Canadian research network focused on ageing and technology, we explored how technologies currently being developed to support older adults and their caregivers fare through the processes of innovation. We conducted a multiple case study focused on development of four technology products. Read More

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http://dx.doi.org/10.1177/0840470420936715DOI Listing

Impact of COVID-19 on U.S. and Canadian neurologists' therapeutic approach to multiple sclerosis: a survey of knowledge, attitudes, and practices.

J Neurol 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Massachusetts General Hospital, 165 Cambridge Street, Office 627, Boston, MA, 02114, USA.

Objective: To report the understanding and decision-making of neuroimmunologists and their treatment of patients with multiple sclerosis (MS) during the early stages of the SARS-CoV-2 (COVID-19) outbreak.

Methods: A survey instrument was designed and distributed online to neurologists in April 2020.

Results: There were 250 respondents (response rate 21. Read More

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http://dx.doi.org/10.1007/s00415-020-10045-9DOI Listing

Context for interpreting equilibrium climate sensitivity and transient climate response from the CMIP6 Earth system models.

Sci Adv 2020 Jun 24;6(26):eaba1981. Epub 2020 Jun 24.

Deutsches Zentrum für Luft- und Raumfahrt (DLR), Institut für Physik der Atmosphäre, Oberpfaffenhofen, Germany.

For the current generation of earth system models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6), the range of equilibrium climate sensitivity (ECS, a hypothetical value of global warming at equilibrium for a doubling of CO) is 1.8°C to 5.6°C, the largest of any generation of models dating to the 1990s. Read More

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http://dx.doi.org/10.1126/sciadv.aba1981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314520PMC

Policy-influencer perspectives on the development, adoption, and implementation of provincial school-based daily physical activity policies across Canada: A national case study.

SSM Popul Health 2020 Aug 8;11:100612. Epub 2020 Jun 8.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

Objectives: School-based daily physical activity (DPA) policies represent a promising intervention for increasing physical activity levels among children. Between 2005 and 2010, five Canadian provinces adopted and implemented DPA policies. This national case study explored facilitators and challenges to developing, adopting and implementing DPA policies from the perspective of key stakeholders ('policy-influencers') in these five provinces. Read More

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http://dx.doi.org/10.1016/j.ssmph.2020.100612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327280PMC

Dataset on cost-analysis of medication deprescribing scenarios for older adult coverage under public drug benefit programs in Canada.

Data Brief 2020 Aug 8;31:105842. Epub 2020 Jun 8.

Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Canada.

The dataset covers the equations and procedure used for the estimation of an older adult's total annual medication costs, across Canadian provinces and territories; detailed to report pharmacy margin, government share, and patient share. We presented a case of an older adult using 10 different medications commonly used, according to Canadian Institute for Health Information. Eight different deprescribing scenarios were created, based on recommendations from Beers Criteria and the Canadian Deprescribing Network, for the purpose of comparing the cost difference before and after each intervention on pharmacies, patients, and governments. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327419PMC

The hidden complexity of measuring number of chronic conditions using administrative and self-report data: A short report.

J Comorb 2020 Jan-Dec;10:2235042X20931287. Epub 2020 Jun 26.

School of Nursing, McMaster University, Hamilton, ON, Canada.

Objective: To examine agreement between administrative and self-reported data on the number of and constituent chronic conditions (CCs) used to measure multimorbidity.

Study Design And Setting: Cross-sectional self-reported survey data from four Canadian Community Health Survey waves were linked to administrative data for residents of Ontario, Canada. Agreement for each of 12 CCs was assessed using kappa () statistics. Read More

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http://dx.doi.org/10.1177/2235042X20931287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323264PMC

Is Canadian federal legislation effective in preventing youth access to vaping initiation products? A study using secret shoppers and online access in three Alberta cities.

Prev Med Rep 2020 Sep 15;19:101117. Epub 2020 May 15.

Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

The (Canada, 1997) (the "") aims to protect the health of young persons by restricting access to vaping products. We studied whether the achieves this goal by sending young 'secret shoppers' to 120 shops in Calgary, Edmonton, and Red Deer to attempt to buy nicotine-based vaping-initiation products, and by asking minors to purchase the same product online. We used three 'improper' shop scenarios: 1. Read More

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http://dx.doi.org/10.1016/j.pmedr.2020.101117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327845PMC
September 2020

Guidance on authorship with and acknowledgement of patient partners in patient-oriented research.

Res Involv Engagem 2020 2;6:38. Epub 2020 Jul 2.

Chronic Pain Network, McMaster University, Hamilton, Ontario Canada.

The Strategy for Patient-Oriented Research Chronic Pain Network was founded in 2016 and is a patient-oriented research network funded by the Canadian Institutes of Health Research. The Network incorporates patient partners throughout its governance and operations meaning that patient partners may contribute to research projects in ways that warrant scientific authorship as defined by the International Committee of Medical Journal Editors. The Network did a brief informal review of guidance on patient authorship in 2019, but could not find any practical documentation to guide its members on this topic. Read More

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http://dx.doi.org/10.1186/s40900-020-00213-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331134PMC

Improving ergonomics in the operating room for orthopaedic surgeons in order to reduce work-related musculoskeletal injuries.

Ann Med Surg (Lond) 2020 Aug 23;56:133-138. Epub 2020 Jun 23.

Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada.

Introduction: Orthopaedic surgery is characterized by surgical tasks that are physical, repetitive and require some degree of stamina from the surgeon. Occupational injuries are alarmingly common in orthopaedic surgery with two-thirds of all surgeons reporting a work-related musculoskeletal (MSK) injury during their career. One of the leading causes of the high level of MSK injuries among orthopaedic surgeon is lack of ergonomics of the operating room. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327029PMC

Impact of neuropathic pain on participation: perspectives from the Canadian SCI community survey.

Spinal Cord 2020 Jul 7. Epub 2020 Jul 7.

Center for Interdisciplinary Research in Rehabilitation and Social Integration, Quebec City, QC, Canada.

Study Design: Secondary analysis of an observational cohort study.

Objectives: To determine if the perceived overall limitation of neuropathic pain on activities (NP limitation) covaries in 26 specific life activities in people with SCI, taking into account the severity of injury.

Setting: Community-based in Canada. Read More

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http://dx.doi.org/10.1038/s41393-020-0512-9DOI Listing

ERA5-based global meteorological wildfire danger maps.

Sci Data 2020 Jul 7;7(1):216. Epub 2020 Jul 7.

European Centre for Medium-range Weather Forecasts, Reading, United Kingdom.

Forest fires are an integral part of the natural Earth system dynamics, however they are becoming more devastating and less predictable as anthropogenic climate change exacerbates their impacts. In order to advance fire science, fire danger reanalysis products can be used as proxy for fire weather observations with the advantage of being homogeneously distributed both in space and time. This manuscript describes a reanalysis dataset of fire danger indices based on the Canadian Fire Weather Index system and the ECMWF ERA5 reanalysis dataset, which supersedes the previous dataset based on ERA-Interim. Read More

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http://dx.doi.org/10.1038/s41597-020-0554-zDOI Listing

Genomic Analysis of Bovine Staphylococcus aureus Isolates from Milk To Elucidate Diversity and Determine the Distributions of Antimicrobial and Virulence Genes and Their Association with Mastitis.

mSystems 2020 Jul 7;5(4). Epub 2020 Jul 7.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

causes persistent clinical and subclinical bovine intramammary infections (IMI) worldwide. However, there is a lack of comprehensive information regarding genetic diversity, the presence of antimicrobial resistance (AMR), and virulence genes for in bovine milk in Canada. Here, we performed whole-genome sequencing (WGS) of 119 Canadian bovine milk isolates and determined they belonged to 8 sequence types (ST151, ST352, ST351, ST2187, ST2270, ST126, ST133, and ST8), 5 clonal complexes (CC151, CC97, CC126, CC133, and CC8), and 18 distinct Spa types. Read More

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http://dx.doi.org/10.1128/mSystems.00063-20DOI Listing

Factors associated with early opioid dispensing compared with NSAID and muscle relaxant dispensing after a work-related low back injury.

Occup Environ Med 2020 Jul 7. Epub 2020 Jul 7.

Institute for Work and Health, Toronto, Ontario, Canada.

Objectives: The objective of this historical cohort study was to determine the claimant and prescriber factors associated with receiving opioids at first postinjury dispense compared with non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs) in a sample of workers' compensation claimants with low back pain (LBP) claims between 1998 and 2009 in British Columbia, Canada.

Methods: Administrative workers' compensation, prescription and healthcare data were linked. The association between claimant factors (sociodemographics, occupation, diagnosis, comorbidities, pre-injury prescriptions and healthcare) and prescriber factors (sex, birth year, specialty) with drug class(es) at first dispense (opioids vs NSAIDs/SMRs) was examined with multilevel multinomial logistic regression. Read More

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http://dx.doi.org/10.1136/oemed-2019-106380DOI Listing

Reformulation of sugar contents in Canadian prepackaged foods and beverages between 2013 and 2017 and resultant changes in nutritional composition of products with sugar reductions.

Public Health Nutr 2020 Jul 8:1-9. Epub 2020 Jul 8.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ONM5S 1A8, Canada.

Objective: To quantify total sugar reformulation in Canadian prepackaged foods and beverages between 2013 and 2017 and identify changes in the nutritional composition of the foods and beverages reformulated to be lower in total sugar.

Design: Longitudinal examination of foods and beverages present in both 2013 and 2017 collections of the University of Toronto's Food Label Information Program database (n 6628 matched products). The proportion of products with changes in sugar levels was determined. Read More

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http://dx.doi.org/10.1017/S1368980020001159DOI Listing

In-Hospital Mortality for the Elderly Suffering Acute Traumatic Spinal Cord Injury.

J Neurotrauma 2020 Jul 7. Epub 2020 Jul 7.

The University of British Columbia, 8166, Orthopaedics, Vancouver, British Columbia, Canada.

As the incidence of traumatic spinal cord injury (tSCI) in the elderly rises, clinicians are increasingly faced with difficult discussions regarding aggressiveness of management, likelihood of recovery and survival. Our objective was to outline risk factors associated with in-hospital mortality in elderly surgical and non-surgical patients following tSCI and to determine those unlikely to have a favourable outcome. Data from elderly patients (≥65 years) within the Canadian Rick Hansen SCI Registry from 2004 to 2017 were analyzed using descriptive analysis. Read More

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http://dx.doi.org/10.1089/neu.2019.6912DOI Listing

The Use of Demoralization Scale in Italian Kidney Transplant Recipients.

J Clin Med 2020 Jul 5;9(7). Epub 2020 Jul 5.

Department of Biomedical and Specialty Surgical Sciences, Institute of Psychiatry, University of Ferrara, 44124 Ferrara, Italy.

Demoralization is a commonly observed syndrome in medically ill patients. The risk of demoralization may increase in patients after a kidney transplant (KTRs) because of the stressful nature of renal transplantation, psychosocial challenges, and adjustment needs. No study is available on demoralization amongst KTRs. Read More

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http://dx.doi.org/10.3390/jcm9072119DOI Listing

Multiple Correspondence and Hierarchical Cluster Analyses for the Profiling of Fresh Apple Customers Using Data from Two Marketplaces.

Foods 2020 Jul 3;9(7). Epub 2020 Jul 3.

Summerland Research and Development Centre, Science and Technology Branch, Agriculture and Agri-Food Canada, Summerland, BC V0H 1Z0, Canada.

Purchase behavior and preferences for consumers of fresh apples were investigated using a consumer survey conducted at a special-event apple market. Survey respondents were asked to list apple cultivars they had purchased at the retail market and the special-event market. The special-event market offered many uncommon cultivars packed in clear plastic bags with a fixed weight and price. Read More

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http://dx.doi.org/10.3390/foods9070873DOI Listing

Which Factors Contribute to Frailty among the Oldest Old? Results of the Multicentre Prospective AgeCoDe and AgeQualiDe Study.

Gerontology 2020 Jul 7:1-7. Epub 2020 Jul 7.

Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: There is a lack of studies investigating the link between time-varying factors associated with changes in frailty scores in very old age longitudinally. This is important because the level of frailty is associated with subsequent morbidity and mortality.

Objective: To examine time-dependent predictors of frailty among the oldest old using a longitudinal approach. Read More

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http://dx.doi.org/10.1159/000508723DOI Listing

Inflammatory bowel disease nurses' perspectives: Prioritizing adolescent transition readiness factors.

J Pediatr Nurs 2020 Jul 4;55:29-39. Epub 2020 Jul 4.

Education & Music Library, University of Saskatchewan, 28 Campus Drive, Room 2003.7A Education Bldg., Saskatoon, SK S7N 0X1, Canada. Electronic address:

Purpose: Despite the wealth of knowledge and expertise that Inflammatory Bowel Disease (IBD) nurses bring to the transition process, health literature lacks nurses' perspectives on transition readiness. The purpose of study was to ask IBD nurses to prioritize care transition readiness factors for adolescents living with IBD.

Design And Methods: The cross-sectional exploratory survey was researcher-developed and distributed online to IBD nurses across Canada. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.011DOI Listing

Formal and informal care received by middle-aged and older adults with chronic conditions in Canada: CLSA data.

PLoS One 2020 7;15(7):e0235774. Epub 2020 Jul 7.

Centre for Health Evaluation and Outcome Sciences, Vancouver, British Columbia, Canada.

Background: Middle-aged and older adults are more likely to suffer from chronic conditions, which can increase their need for both formal and informal care. This study seeks to assess and compare the extent to which the use of formal and informal care is attributed to different chronic conditions among middle-aged and older women and men in Canada.

Methods: We used baseline data from the Canadian Longitudinal Study on Aging (CLSA). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235774PLOS

Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing.

Transfusion 2020 Jul 6. Epub 2020 Jul 6.

Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada.

Treatment of red blood cells with dithiothreitol (DTT) or trypsin effectively denatures CD38; however, this treatment damages other antigens, some of which are of clinical importance. Thus, other avenues to deplete daratumumab (DARA) from plasma samples should be explored.

Study Design And Methods: The Daudi B-cell line was found to express high levels of CD38 and was sonicated in a sonication buffer to achieve complete cell lysis. Read More

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http://dx.doi.org/10.1111/trf.15932DOI Listing

Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC).

J Neurooncol 2020 Jul 7. Epub 2020 Jul 7.

Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.

Background: Diffuse intrinsic pontine gliomas (DIPG) are midline gliomas that arise from the pons and the majority are lethal within a few months after diagnosis. Due to the lack of histological diagnosis the epidemiology of DIPG is not completely understood. The aim of this report is to provide population-based data to characterize the descriptive epidemiology of this condition in Canadian children. Read More

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http://dx.doi.org/10.1007/s11060-020-03568-8DOI Listing

Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients.

J Neurooncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G2M9, Canada.

Introduction: Tumor-related epilepsy may respond to chemotherapy. In a previously-published multi-centre randomized clinical trial of 562 elderly glioblastoma patients, temozolomide plus short-course radiotherapy conferred a survival benefit over radiotherapy alone. Seizure outcomes were not reported. Read More

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http://dx.doi.org/10.1007/s11060-020-03573-xDOI Listing

Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes.

AMB Express 2020 Jul 6;10(1):120. Epub 2020 Jul 6.

Oral Ecology Research Group, Faculty of Dentistry, Université Laval, 2420 de la Terrasse, Quebec City, QC, G1V 0A6, Canada.

Enterococcus faecalis is one of the bacterial species most frequently isolated from persistent endodontic and apical periodontal infections. The aim of the present study was to evaluate the synergistic antibacterial effects of nisin and selected licorice polyphenols (glabridin, licoricidin, licochalcone A) against planktonic and biofilm-embedded E. faecalis cells. Read More

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http://dx.doi.org/10.1186/s13568-020-01056-wDOI Listing

Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung.

MAGMA 2020 Jul 6. Epub 2020 Jul 6.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.

Objective: Diffusion-weighted, hyperpolarized Xe MRI is useful for the characterization of microstructural changes in the lung. A stretched exponential model was proposed for morphometric extraction of the mean chord length (L) from diffusion-weighted data. The stretched exponential model enables accelerated mapping of L in a single-breathhold using compressed sensing. Read More

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http://dx.doi.org/10.1007/s10334-020-00860-6DOI Listing

Identification and characterization of Colletotrichum species causing apple bitter rot in New York and description of C. noveboracense sp. nov.

Sci Rep 2020 Jul 6;10(1):11043. Epub 2020 Jul 6.

Cornell University, Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Hudson Valley Research Laboratory, Highland, NY, USA.

Apple bitter rot caused by Colletotrichum species is a growing problem worldwide. Colletotrichum spp. are economically important but taxonomically un-resolved. Read More

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http://dx.doi.org/10.1038/s41598-020-66761-9DOI Listing

Atypical age-related changes in cortical thickness in autism spectrum disorder.

Sci Rep 2020 Jul 6;10(1):11067. Epub 2020 Jul 6.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Dr, Burnaby, BC, V5A 1S6, Canada.

Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (ASD). It is not clear, however, which aspects of age-related changes (trajectories) would be optimal for identifying atypical brain development in ASD. Using a large cross-sectional data set (Autism Brain Imaging Data Exchange [ABIDE] repository; releases I and II), we aimed to explore age-related changes in cortical thickness (CT) in TD and ASD populations (age range 6-30 years old). Read More

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http://dx.doi.org/10.1038/s41598-020-67507-3DOI Listing

Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.

CMAJ 2020 Jul;192(27):E768-E777

Department of Community Health Sciences (Groulx), University of Sherbrooke, Sherbrooke, Que.; Public Health Agency of Canada (Limburg, Doull), Ottawa, Ont.; Department of Medicine (Klarenbach), University of Alberta, Edmonton, Alta.; Internal Medicine and Community Health Sciences (Singh), University of Manitoba, Winnipeg, Man.; Community Health and Humanities (Wilson), Memorial University, St. John's, Nfld.; Department of Psychiatry (Thombs), Jewish General Hospital and McGill University, Montréal, Que.

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http://dx.doi.org/10.1503/cmaj.190814DOI Listing

Relationship between motoric cognitive risk syndrome, cardiovascular risk factors and diseases, and incident cognitive impairment: Results from the "NuAge" study.

Maturitas 2020 Aug 16;138:51-57. Epub 2020 May 16.

Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland.

Background: Motoric Cognitive Risk syndrome (MCR), which combines Subjective Cognitive Complaint (SCC) and slow gait speed in individuals free of dementia and gait disability, is associated with cardiovascular risk factors and diseases as well as incident cognitive impairment. Little information on MCR exists in the Canadian population. This study aims to examine these associations in community-dwelling elderly people living in Quebec, which is a Canadian province. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.007DOI Listing

Chinese- and English-speaking adult current smokers' perspectives on smoking and culturally and linguistically appropriate cessation: a qualitative analysis.

Addict Sci Clin Pract 2020 Jul 6;15(1):23. Epub 2020 Jul 6.

UBC, Faculty of Medicine, Respiratory Medicine Division, Centre for Clinical Epidemiology and Evaluation (C2E2), Vancouver General Hospital - Research Pavilion, 716-828 West 10th Ave, Vancouver, BC, V5Z 1M9, Canada.

Background: A lack of culturally and linguistically appropriate smoking cessation intervention programs exist among Chinese-Canadian communities. Smoking cessation programs that are provided in Canadian mainstream culture and language have shown limited effectiveness in altering smoking behaviours of smokers from these communities. Our study aimed to explore and compare smoking patterns, knowledge, beliefs, and risk perceptions of adult current smokers between Chinese- and English-speaking Canadians participating in a culturally and linguistically tailored smoking cessation program. Read More

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http://dx.doi.org/10.1186/s13722-020-00197-4DOI Listing

Street masking: a network-based geographic mask for easily protecting geoprivacy.

Int J Health Geogr 2020 Jul 6;19(1):26. Epub 2020 Jul 6.

Department of Pediatrics, School of Population and Public Health, University of British Columbia, British Columbia Injury Research and Prevention Unit, British Columbia Children's Hospital Research Institute, F511-4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.

Background: Geographic masks are techniques used to protect individual privacy in published maps but are highly under-utilized in research. This leads to continual violations of individual privacy, as sensitive health records are put at risk in unmasked maps. New approaches to geographic masking are required that foster accessibility and ease of use, such that they become more widely adopted. Read More

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http://dx.doi.org/10.1186/s12942-020-00219-zDOI Listing

Impact of the COVID-19 virus outbreak on movement and play behaviours of Canadian children and youth: a national survey.

Int J Behav Nutr Phys Act 2020 07 6;17(1):85. Epub 2020 Jul 6.

Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.

Background: Healthy childhood development is fostered through sufficient physical activity (PA; including time outdoors), limiting sedentary behaviours (SB), and adequate sleep; collectively known as movement behaviours. Though the COVID-19 virus outbreak has changed the daily lives of children and youth, it is unknown to what extent related restrictions may compromise the ability to play and meet movement behaviour recommendations. This secondary data analysis examined the immediate impacts of COVID-19 restrictions on movement and play behaviours in children and youth. Read More

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http://dx.doi.org/10.1186/s12966-020-00987-8DOI Listing

Epidemiology of drug driving: protocol from a national Canadian study measuring levels of cannabis, alcohol and other substances in injured drivers.

BMC Public Health 2020 Jul 6;20(1):1070. Epub 2020 Jul 6.

Department of Emergency Medicine, Faculty of Medicine, The University of British Columbia, 828 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada.

Background: Drug driving is an emerging global road safety problem. As the prevalence of alcohol-impaired driving decreases, and as more jurisdictions decriminalize or legalize cannabis, it is increasingly important for policy makers to have accurate information on the prevalence and pattern of drug driving. Unfortunately, this data is not widely available and the World Health Organization identifies lack of accurate data on the prevalence of drug driving as an important knowledge gap. Read More

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http://dx.doi.org/10.1186/s12889-020-09176-5DOI Listing

Patterns of fish and whale consumption in relation to methylmercury in hair among residents of Western Canadian Arctic communities.

BMC Public Health 2020 Jul 6;20(1):1073. Epub 2020 Jul 6.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Background: Methylmercury contamination of the environment represents a substantial environmental health concern. Human exposure to methylmercury occurs primarily through consumption of fish and marine mammals. Heavily exposed subgroups include sport or subsistence fishers residing in Arctic communities. Read More

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http://dx.doi.org/10.1186/s12889-020-09133-2DOI Listing

Canadian Public Safety Personnel and Occupational Stressors: How PSP Interpret Stressors on Duty.

Int J Environ Res Public Health 2020 Jul 1;17(13). Epub 2020 Jul 1.

Department of Sociology, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.

Canadian public safety personnel (e.g., correctional workers, firefighters) experience potential stressors as a function of their occupation. Read More

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http://dx.doi.org/10.3390/ijerph17134736DOI Listing

Effects of the COVID-19 pandemic on supply and use of blood for transfusion.

Lancet Haematol 2020 Jul 3. Epub 2020 Jul 3.

Manchester University NHS Foundation Trust, Manchester, UK.

The COVID-19 pandemic has major implications for blood transfusion. There are uncertain patterns of demand, and transfusion institutions need to plan for reductions in donations and loss of crucial staff because of sickness and public health restrictions. We systematically searched for relevant studies addressing the transfusion chain-from donor, through collection and processing, to patients-to provide a synthesis of the published literature and guidance during times of potential or actual shortage. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30186-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333996PMC

Knock-out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post-myocardial infarction.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Toronto General Research Institute, University Health Network, Toronto, ON, Canada.

Prevention of infarct scar thinning and dilatation and stimulation of scar contracture can prevent progressive heart failure. Since microRNA 145 (miR-145) plays an important role in cardiac fibroblast response to wound healing and cardiac repair after an myocardial infarction (MI), using a miR-145 knock-out (KO) mouse model, we evaluated contribution of down-regulation of miR-145 to cardiac fibroblast and myofibroblast function during adverse cardiac remodelling. Cardiac function decreased more and the infarct size was larger in miR-145 KO than that in WT mice after MI and this phenomenon was accompanied by a decrease in cardiac fibroblast-to-myofibroblast differentiation. Read More

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http://dx.doi.org/10.1111/jcmm.15597DOI Listing

Is mammography screening beneficial: An individual-based stochastic model for breast cancer incidence and mortality.

PLoS Comput Biol 2020 Jul 6;16(7):e1008036. Epub 2020 Jul 6.

Department of Mathematics, University of Utah, Salt Lake City, Utah, United States of America.

The benefits of mammography screening have been controversial, with conflicting findings from various studies. We hypothesize that unmeasured heterogeneity in tumor aggressiveness underlies these conflicting results. Based on published data from the Canadian National Breast Screening Study (CNBSS), we develop and parameterize an individual-based mechanistic model for breast cancer incidence and mortality that tracks five stages of breast cancer progression and incorporates the effects of age on breast cancer incidence and all-cause mortality. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1008036DOI Listing

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.

PLoS Med 2020 Jul 6;17(7):e1003172. Epub 2020 Jul 6.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The "trimorbidity" of substance use disorder and mental and physical illness is associated with living in precarious housing or homelessness. The extent to which substance use increases risk of psychosis and both contribute to mortality needs investigation in longitudinal studies.

Methods And Findings: A community-based sample of 437 adults (330 men, mean [SD] age 40. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003172DOI Listing