9,195 results match your criteria Campylobacter Infections


The use of aminoglycosides in animals within the EU: development of resistance in animals and possible impact on human and animal health: a review.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

Veterinary Medicines Directorate, Addlestone, UK.

Aminoglycosides (AGs) are important antibacterial agents for the treatment of various infections in humans and animals. Following extensive use of AGs in humans, food-producing animals and companion animals, acquired resistance among human and animal pathogens and commensal bacteria has emerged. Acquired resistance occurs through several mechanisms, but enzymatic inactivation of AGs is the most common one. Read More

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http://dx.doi.org/10.1093/jac/dkz161DOI Listing

Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens.

Sci Rep 2019 Apr 17;9(1):6204. Epub 2019 Apr 17.

Department of Zoology, University of Oxford, The Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, OX1 3SY, UK.

Chicken meat represents an important source of Campylobacter infections of humans world-wide. A better understanding of Campylobacter epidemiology in commercial chicken flocks will facilitate the development of more effective intervention strategies. We developed a gene-specific parallel sequencing approach that efficiently indicated genetic diversity in farm-derived samples and revealed Campylobacter genotypes that would not be detected using microbiological culture. Read More

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http://www.nature.com/articles/s41598-019-42207-9
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http://dx.doi.org/10.1038/s41598-019-42207-9DOI Listing
April 2019
1 Read

Integrons and antibiotic resistance genes in water-borne pathogens: threat detection and risk assessment.

J Med Microbiol 2019 Apr 16. Epub 2019 Apr 16.

1 Medical Microbiology and Bioprocess Technology Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana 124001, India.

Antibiotic-resistant genes (ARGs) are regarded as emerging environmental pollutants and pose a serious health risk to the human population. Integrons are genetic elements that are involved in the spread of ARGs amongst bacterial species. They also act as reservoirs of these resistance traits, further contributing to the development of multi-drug resistance in several water-borne pathogens. Read More

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http://dx.doi.org/10.1099/jmm.0.000972DOI Listing

Protease Activity of HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice.

Front Cell Infect Microbiol 2019 29;9:79. Epub 2019 Mar 29.

Institute of Microbiology, Infectious Diseases and Immunology, Charité - University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Even though human infections are progressively increasing worldwide, the underlying molecular mechanisms of pathogen-host-interactions are still not fully understood. We have recently shown that the secreted serine protease HtrA plays a key role in cellular invasion and transepithelial migration , and is involved in the onset of intestinal pathology in murine infection models . In the present study, we investigated whether the protease activity of HtrA had an impact in induced acute enterocolitis. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00079
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http://dx.doi.org/10.3389/fcimb.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449876PMC
March 2019
4 Reads

Antecedent infections in Fisher syndrome: sources of variation in clinical characteristics.

J Neurol 2019 Apr 6. Epub 2019 Apr 6.

Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Minami-kogushi 1-1-1, Ube, Yamaguchi, 755-8505, Japan.

The clinical features of Guillain-Barré syndrome (GBS) are highly variable, according to the type of antecedent infection. Although a major GBS phenotype, Fisher syndrome (FS), has been shown to be preceded by infections similar to those preceding GBS, whether or not the clinical features in FS also vary according to antecedent infection remains unclarified. Frequent antecedent infections among this study of 70 FS patients included Haemophilus influenzae [n = 15 (21%)], Campylobacter jejuni [n = 10 (14%)], and cytomegalovirus (CMV) [n = 6 (8. Read More

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http://dx.doi.org/10.1007/s00415-019-09308-xDOI Listing
April 2019
2 Reads

Intestinal colonization and acute immune response in commercial turkeys following inoculation with Campylobacter jejuni constructs encoding antibiotic-resistance markers.

Vet Immunol Immunopathol 2019 Apr 1;210:6-14. Epub 2019 Mar 1.

Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.

Consumption of contaminated poultry products is one of the main sources of human campylobacteriosis, of which Campylobacter jejuni subsp. jejuni (C. jejuni) is responsible for approximately 90% of the cases. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.02.003DOI Listing

Exploring seasonality across Europe using The European Surveillance System (TESSy), 2008 to 2016.

Euro Surveill 2019 Mar;24(13)

European Centre for Disease Prevention and Control, Stockholm, Sweden.

BackgroundCampylobacteriosis is the most commonly reported food-borne infection in the European Union, with an annual number of cases estimated at around 9 million. In many countries, campylobacteriosis has a striking seasonal peak during early/mid-summer. In the early 2000s, several publications reported on campylobacteriosis seasonality across Europe and associations with temperature and precipitation. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.13.180028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446507PMC

[What is the REAL long-term risk of proton pump inhibitors?]

Presse Med 2019 Mar 26. Epub 2019 Mar 26.

Assistance publique Hôpitaux de Paris (AP-HP), hôpital Cochin, service de gastroentérologie, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris-Descartes, 12, rue de l'École de médecine, 75006 Paris, France. Electronic address:

Proton pump inhibitors (PPIs) are among the most prescribed drugs in the world. While their efficacy in acute management is indisputable, it has long been suggested that PPI therapy is safe in the long term. In recent years, there has been growing and justified concern about the long-term risks of PPIs. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.02.011DOI Listing
March 2019
1 Read

Fluoroquinolone-Resistant Salmonella enterica, Campylobacter spp., and Arcobacter butzleri from Local and Imported Poultry Meat in Kumasi, Ghana.

Foodborne Pathog Dis 2019 Mar 23. Epub 2019 Mar 23.

1 Department Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.

Salmonella and Campylobacter are important gastroenteric pathogens. Arcobacter butzleri is an emerging enteric pathogen. Data on the frequencies of these poultry-associated pathogens on meat products sold in sub-Saharan Africa are scarce. Read More

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http://dx.doi.org/10.1089/fpd.2018.2562DOI Listing
March 2019
1 Read

Characterization of the enterobactin-specific antibodies induced by a novel enterobactin conjugate vaccine.

Appl Environ Microbiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Animal Science, The University of Tennessee, Knoxville, TN, USA

Enterobactin (Ent)-mediated high affinity iron acquisition is critical for Gram-negative bacteria to survive in the host. Given the bacteriostatic effect of lipocalin resulting from its potent Ent-binding ability, immune intervention directly targeting Ent is promising for iron-dependent pathogen control. Recently, an Ent conjugate vaccine was reported but it still has several significant weaknesses. Read More

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http://dx.doi.org/10.1128/AEM.00358-19DOI Listing

Detection and characterisation of canine astrovirus, canine parvovirus and canine papillomavirus in puppies using next generation sequencing.

Sci Rep 2019 Mar 14;9(1):4602. Epub 2019 Mar 14.

Geelong Centre for Emerging Infectious Diseases, Geelong, VIC, 3220, Australia.

Gastroenteritis in young animals is a clinical presentation with many infectious and non- infectious aetiologies. We used next generation sequencing (NGS) to investigate the possible infectious causes of gastroenteritis in puppies from a dog kennel in Victoria, Australia. The near complete genome of a canine astrovirus was obtained from pooled faecal samples, and was found to be 94. Read More

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http://dx.doi.org/10.1038/s41598-019-41045-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418273PMC

The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan.

Epidemiol Infect 2019 Jan;147:e134

Veterinary Epidemiology, Economics and Public Health Group,The Royal Veterinary College,Hawkshead Lane, North Mymms, AL9 7TA, Hatfield,UK.

Campylobacter is the leading cause of foodborne bacterial gastroenteritis in humans worldwide, often associated with the consumption of undercooked poultry. In Jordan, the majority of broiler chicken production occurs in semi-commercial farms, where poor housing conditions and low bio-security are likely to promote campylobacter colonisation. While several studies provided estimates of the key parameters describing the within-flock transmission dynamics of campylobacter in typical high-income countries settings, these data are not available for Jordan and Middle-East in general. Read More

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http://dx.doi.org/10.1017/S0950268818003308DOI Listing
January 2019
3 Reads

Campylobacter jejuni capsule types in a Peruvian birth cohort and associations with diarrhoeal disease severity.

Epidemiol Infect 2019 Jan;147:e149

Enteric Diseases Department,Naval Medical Research Center,Silver Spring, Maryland,USA.

Campylobacter jejuni is a leading cause of bacterial diarrhoea worldwide. The objective of this study was to examine the association between C. jejuni capsule types and clinical signs and symptoms of diarrhoeal disease in a well-defined birth cohort in Peru. Read More

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http://dx.doi.org/10.1017/S0950268818002960DOI Listing
January 2019
5 Reads
2.535 Impact Factor

Seasonality and the effects of weather on Campylobacter infections.

BMC Infect Dis 2019 Mar 13;19(1):255. Epub 2019 Mar 13.

Statistics, Modelling and Economics Department, National Infection Service, Public Health England, 61, Colindale Avenue, London, NW9 5EQ, UK.

Background: Campylobacteriosis is a major public health concern. The weather factors that influence spatial and seasonal distributions are not fully understood.

Methods: To investigate the impacts of temperature and rainfall on Campylobacter infections in England and Wales, cases of Campylobacter were linked to local temperature and rainfall at laboratory postcodes in the 30 days before the specimen date. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3840-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417031PMC
March 2019
2 Reads

Reaction of antibodies to and cytolethal distending toxin B with tissues and food antigens.

World J Gastroenterol 2019 Mar;25(9):1050-1066

Regenera Medical, Los Angeles, CA 90025, United States.

Background: The bacteria () is commonly associated with Guillane-Barré syndrome (GBS) and irritable bowel syndrome (IBS), but studies have also linked it with Miller Fisher syndrome, reactive arthritis and other disorders, some of which are autoimmune. It is possible that and its toxins may be cross-reactive with some human tissues and food antigens, potentially leading to autoimmune responses.

Aim: To measure the immune reactivity of and cytolethal distending toxin (Cdt) antibodies with tissue and food antigens to examine their role in autoimmunities. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i9/1050.htm
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http://dx.doi.org/10.3748/wjg.v25.i9.1050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406185PMC
March 2019
9 Reads

A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated PCR Ribotype 078.

MBio 2019 03 12;10(2). Epub 2019 Mar 12.

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

The increasing clinical importance of human infections (frequently severe) caused by PCR ribotype 078 (RT078) was first reported in 2008. The severity of symptoms (mortality of ≤30%) and the higher proportion of infections among community and younger patients raised concerns. Farm animals, especially pigs, have been identified as RT078 reservoirs. Read More

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http://dx.doi.org/10.1128/mBio.02790-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414706PMC
March 2019
2 Reads

Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection.

BMC Infect Dis 2019 Mar 7;19(1):237. Epub 2019 Mar 7.

Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland.

Background: The clinical course of Campylobacter infection varies in symptoms and severity depending on host factors, virulence of the pathogen and initiated therapy. The type VI secretion system (T6SS) has been identified as a novel virulence factor, which mediates contact-dependent injection of enzymes and toxins into competing bacteria or host cells and facilitates the colonisation of a host organism. We aimed to compare the clinical course of Campylobacter infection caused by strains with and without the T6SS and identify possible associations between this putative virulence factor and the clinical manifestations of disease. Read More

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http://dx.doi.org/10.1186/s12879-019-3858-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407262PMC
March 2019
2 Reads

Foodborne diseases do not respect borders: Zoonotic pathogens and antimicrobial resistant bacteria in food products of animal origin illegally imported into the European Union.

Vet J 2019 Feb 12;244:75-82. Epub 2018 Dec 12.

German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, D-12277 Berlin, Germany.

Globalisation, international trade and the ever-growing flow of goods and people enable animal diseases and zoonotic pathogens to travel worldwide. The risk of reintroducing previously eradicated animal diseases into the European Union is omnipresent as considerable amounts of food products of animal origin (POAO) from endemic countries are continuously imported legally and illegally into the EU. Additionally, these products may be potential vectors for emerging foodborne zoonoses, which are of public health concern due to their significant morbidity and mortality rates. Read More

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http://dx.doi.org/10.1016/j.tvjl.2018.12.009DOI Listing
February 2019
2 Reads

Campylobacteriosis in Poland in 2015 and 2016

Przegl Epidemiol 2018 ;72(4):399-405

National Institute of Public Health – National Institute of Hygiene in Warsaw, Department of Epidemiology of Infectious Diseases and Surveillance

Objective: The aim of this study is to assess the epidemiological situation of campylobacteriosis in Poland in 2015 and 2016 in comparison to the previous years.

Material And Methods: The evaluation is based on analysis of data from the annual bulletins „Infectious diseases and poisoning in Poland”, information from individual campylobacter case reports sent to the Department of Epidemiology of Infectious Diseases and Surveillance, NIPH-NIH by regional sanitary-epidemiological stations, information on outbreaks sent by local sanitary-epidemiological stations through the system ROE (Electronic Registry of Epidemic Outbreaks) and data on deaths from the Department of Demographic Studies of the Central Statistical Office.

Results: In Poland in 2015 653 cases of campylobacteriosis were registered, in 2016 – 787 cases. Read More

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http://dx.doi.org/10.32394/pe.72.4.15DOI Listing
January 2018

Role of putative virulence traits of Campylobacter jejuni in regulating differential host immune responses.

J Microbiol 2019 Apr 22;57(4):298-309. Epub 2019 Feb 22.

Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal, 741246, India.

Among the major enteric pathogens, Campylobacter jejuni is considered an important source of diarrheal illness in humans. In contrast to the acute gastroenteritis in humans, C. jejuni exhibits prolonged cecal colonization at a high level with little or no pathology in chickens. Read More

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http://dx.doi.org/10.1007/s12275-019-8165-0DOI Listing
April 2019
1 Read

Campylobacteriosis Outbreak Associated with Contaminated Municipal Water Supply - Nebraska, 2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 22;68(7):169-173. Epub 2019 Feb 22.

In March 2017, the Nebraska Department of Health and Human Services (NDHHS) and the Southwest Nebraska Public Health Department were notified of an apparent cluster of Campylobacter jejuni infections in city A and initiated an investigation. Overall, 39 cases were investigated, including six confirmed and 33 probable. Untreated, unboiled city A tap water (i. Read More

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http://dx.doi.org/10.15585/mmwr.mm6807a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385708PMC
February 2019
5 Reads

Genomic correlates of extraintestinal infection are linked with changes in cell morphology in Campylobacter jejuni.

Microb Genom 2019 Feb 19;5(2). Epub 2019 Feb 19.

5​EpiLab, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Campylobacter jejuni is the most common cause of bacterial diarrheal disease in the world. Clinical outcomes of infection can range from asymptomatic infection to life-threatening extraintestinal infections. This variability in outcomes for infected patients has raised questions as to whether genetic differences between C. Read More

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http://dx.doi.org/10.1099/mgen.0.000251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421344PMC
February 2019

Effects of child and maternal Histo Blood Group Antigen status on symptomatic and asymptomatic enteric infections in early childhood.

J Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA.

Background: Histo blood group antigens (HBGAs) such as fucosyltransferase FUT2 and 3 may act as innate host factors that differentially influence susceptibility of individuals and their offspring to pediatric enteric infections.

Methods: In three community-based birth cohorts, FUT2 and FUT3 statuses were ascertained for mother-child dyads. qPCR panels tested 3,663 diarrheal and 18,148 asymptomatic stool samples for 29 enteropathogens. Read More

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http://dx.doi.org/10.1093/infdis/jiz072DOI Listing
February 2019
2 Reads
5.997 Impact Factor

Virulence-Related Genes and Coenteropathogens Associated with Clinical Outcomes of Enteropathogenic Infections in Children from the Brazilian Semiarid Region: a Case-Control Study of Diarrhea.

J Clin Microbiol 2019 Apr 28;57(4). Epub 2019 Mar 28.

Institute of Biomedicine for Brazilian Semiarid, Federal University of Ceará, Fortaleza, Brazil.

Enteropathogenic (EPEC) is a major cause of diarrhea in children from developing countries and presents high genetic variability. We aimed to characterize the EPEC virulence-related gene (VRG) distribution and copathogens associated with diarrhea and nutrition-related outcomes in children from the low-income Brazilian semiarid region. A cross-sectional case-control study of diarrhea was conducted in 1,191 children aged 2 to 36 months from the northeast region of Brazil. Read More

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http://dx.doi.org/10.1128/JCM.01777-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440785PMC
April 2019
4 Reads

Longitudinal Study of Shiga Toxin-Producing and on Finnish Dairy Farms and in Raw Milk.

Appl Environ Microbiol 2019 Apr 22;85(7). Epub 2019 Mar 22.

Microbiology Research Unit, Finnish Food Safety Authority Evira, Helsinki, Finland

Shiga toxin-producing (STEC) and are notable health hazards associated with the consumption of raw milk. These bacteria may colonize the intestines of asymptomatic cattle and enter bulk tank milk via fecal contamination during milking. We studied the frequency of STEC O157:H7 and contamination in tank milk ( = 785) and the in-line milk filters of milking machines ( = 631) versus the frequency of isolation from cattle feces ( = 257) on three Finnish dairy farms for 1 year. Read More

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http://dx.doi.org/10.1128/AEM.02910-18DOI Listing
April 2019
1 Read

Older Adults and Parents of Young Children Have Different Handling Practices for Raw Poultry.

J Food Prot 2019 Feb;82(2):200-206

3 Kansas State University, 1310 Research Park Drive, Ice Hall, Manhattan, Kansas 66506, USA.

Salmonella and Campylobacter are among the most common causes of foodborne disease in the United States. Most illnesses are associated with eating raw or undercooked poultry or cross-contamination. Young children and older adults are more susceptible to contracting foodborne illness and have serious infections compared with other age groups. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-323DOI Listing
February 2019
1 Read

Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden.

J Transl Med 2019 Jan 21;17(1):34. Epub 2019 Jan 21.

Institute of Infection and Global Health, Liverpool University, Liverpool, L69 7BE, UK.

Background: With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence is highly seasonal but the underlying mechanisms are poorly understood, making human disease control difficult. We hypothesised that observed disease patterns reflect complex interactions between weather, patterns of human risk behaviour, immune status and level of food contamination. Read More

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http://dx.doi.org/10.1186/s12967-019-1781-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341592PMC
January 2019
3 Reads

Climate-driven QMRA model for selected water supply systems in Norway accounting for raw water sources and treatment processes.

Sci Total Environ 2019 Apr 4;660:306-320. Epub 2019 Jan 4.

Water and Environmental Engineering Group, Department of Civil Engineering, Institute for Marine Operations and Civil Engineering, Norwegian University of Science and Technology (NTNU) in Ålesund, Larsgårdsvegen 2, 6009 Ålesund, Norway.

Formulating effective management intervention measures for water supply systems requires investigation of potential long-term impacts. This study applies an integrated multiple regression, random forest regression, and quantitative microbial risk assessment (QMRA) modelling approach to assess the effect of climate-driven precipitation on pathogen infection risks in three drinking water treatment plants (WTPs) in Norway. Pathogen removal efficacies of treatment steps were calculated using process models. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.460DOI Listing
April 2019
1 Read

Monitoring the incidence and causes of diseases potentially transmitted by food in Australia: Annual report of the OzFoodNet network, 2012.

Authors:

Commun Dis Intell (2018) 2018 16;42. Epub 2018 Nov 16.

This report summarises the incidence of diseases potentially transmitted by food in Australia and details outbreaks associated with food in 2012. OzFoodNet sites reported 27,976 notifications of diseases or conditions that may be transmitted by food. The most commonly notified infections were Campylobacter (15,668 notifications), followed by Salmonella (11,249 notifications). Read More

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November 2018

Antimicrobial Susceptibility and Genomic Structure of Isolates.

Front Microbiol 2018 14;9:3067. Epub 2018 Dec 14.

Institute of Bacterial Infections and Zoonoses (IBIZ), Friedrich Loeffler Institute, Jena, Germany.

spp. are considered the most common bacterial cause of foodborne gastroenteritis in the world. The family includes the genus with the three species , , and as emergent enteropathogens and potential zoonotic agents. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302008PMC
December 2018
2 Reads

The epidemiology of non-viral gastroenteritis in New Zealand children from 1997 to 2015: an observational study.

BMC Public Health 2019 Jan 5;19(1):18. Epub 2019 Jan 5.

Department of Paediatrics, University of Otago, PO Box 4345, Christchurch Mail Centre, Christchurch, 8140, New Zealand.

Background: Acute gastroenteritis is a substantial cause of hospitalization in children. Shigella, Salmonella, Campylobacter, Yersinia, enterotoxigenic Escherichia coli (ETEC), Giardia and Cryptosporidium are gastrointestinal pathogens that are notifiable in New Zealand (NZ). The impact of these infections in the pediatric population has not yet been analyzed. Read More

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http://dx.doi.org/10.1186/s12889-018-6229-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321731PMC
January 2019
2 Reads

Characteristics of Campylobacter, Salmonella Infections and Acute Gastroenteritis in Older Adults in Australia, Canada, and the United States.

Clin Infect Dis 2019 Jan 2. Epub 2019 Jan 2.

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States.

Background: The early detection of enteric infections in older adults is challenging because typical signs and symptoms of disease may be less common, absent, or overlooked. Understanding illness characteristics of enteric infections among older adults could improve the timeliness and accuracy of clinical diagnoses, thereby improving patient outcomes and increasing cases reported to surveillance.

Methods: This study describes illness characteristics (percentage reporting bloody diarrhea, fever, vomiting, abdominal pain, percentage hospitalized, duration of hospitalization, and duration of illness) among older adults (≥65 years) with acute gastroenteritis and culture-confirmed Campylobacter and nontyphoidal Salmonella infections in Australia, Canada, and the United States, and compares these characteristics with those among younger adults (25-64 years) and children (<5 years, 5-24 years). Read More

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http://dx.doi.org/10.1093/cid/ciy1142DOI Listing
January 2019
2 Reads

Investigating locally relevant risk factors for infection in Australia: protocol for a case-control study and genomic analysis.

BMJ Open 2018 Dec 22;8(12):e026630. Epub 2018 Dec 22.

National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australian Capital Territory, Australia.

Introduction: The CampySource project aims to identify risk factors for human infection in Australia. We will investigate locally relevant risk factors and those significant in international studies in a case-control study. Case isolates and contemporaneous isolates from food and animal sources will be sequenced to conduct source attribution modelling, and findings will be combined with the case-control study in a source-assigned analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318611PMC
December 2018
5 Reads

Clade 3 Isolates Induce Rapid Cell Death .

Appl Environ Microbiol 2019 Mar 20;85(5). Epub 2019 Feb 20.

Clinical Microbiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

bacteria are major human enteropathogens. shows less genetic diversity than and clusters into three clades, of which clade 1 includes most human and farm animal isolates, while environmental isolates mainly belong to clades 2 and 3. Recently, we sequenced the whole genomes of eight clade 2 and 3 isolates cultivated from water, and here we studied their interaction with human HT-29 colon cancer cells compared to that of clinical clade 1 isolates. Read More

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http://dx.doi.org/10.1128/AEM.02993-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384112PMC
March 2019
1 Read

Isolation of emerging Campylobacter species in working farm dogs and their frozen home-killed raw meat diets.

J Vet Diagn Invest 2019 Jan 21;31(1):23-32. Epub 2018 Dec 21.

mEpiLab, School of Veterinary Science, Massey University, Palmerston North, New Zealand (Bojanić, Midwinter, Marshall, Biggs).

We applied 7 culture methods to 50 working farm dog fecal samples and 6 methods to 50 frozen home-killed raw meat diet samples to optimize recovery of a wide range of Campylobacter spp. Culture methods combined filtration, enrichment broths, and agars at 37°C and 42°C in conventional and hydrogen-enriched microaerobic atmospheres. Overall, a prevalence of 62% (31 of 50) and 6% (3 of 50) was detected in dog and meat samples, respectively, based on Campylobacter genus PCR. Read More

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http://dx.doi.org/10.1177/1040638718820082DOI Listing
January 2019

Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in and Patients.

Diagnostics (Basel) 2018 Dec 13;8(4). Epub 2018 Dec 13.

Department of Medical Sciences, Clinical Microbiology, Uppsala University, Dag Hammarskjölds väg 38, 75237 Uppsala, Sweden.

Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several tissue destructive diseases, including infections. We measured here serum concentrations of MMP-8 and MMP-9 together with their regulators myeloperoxidase (MPO), human neutrophil elastase (HNE), and tissue inhibitor of metalloproteinases (TIMP)-1 in 80 and 25 patients as well as in 27 healthy controls. Read More

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http://dx.doi.org/10.3390/diagnostics8040082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315616PMC
December 2018
2 Reads

Antimicrobial properties of rosin acids-loaded nanoparticles against antibiotic-sensitive and antibiotic-resistant foodborne pathogens.

Artif Cells Nanomed Biotechnol 2018 7;46(sup3):S414-S422. Epub 2018 Dec 7.

a Institute of Sciences of Food Production , National Research Council (ISPA-CNR) , Bari , Italy.

Rosin acids (RA) from coniferous trees are used in folk medicine for healing various skin infections. Despite the antimicrobial potential of RA, their poor solubility in aqueous media may limit their use. In this work RA-loaded polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticles (RA-NPs) with enhanced antimicrobial properties against foodborne bacterial pathogens were produced. Read More

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http://dx.doi.org/10.1080/21691401.2018.1496924DOI Listing
December 2018
6 Reads

Antibiotic resistance of Campylobacter jejuni isolates recovered from humans with diarrhoea in Turkey.

J Med Microbiol 2019 Feb 12;68(2):136-142. Epub 2018 Dec 12.

3​Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, USA.

Purpose: This study was aimed at investigating the occurrence and genetic mechanisms of resistance to ciprofloxacin, tetracycline and erythromycin in clinical isolates of Campylobacter jejuni recovered from human cases of acute gastroenteritis in Turkey.

Methodology: MIC values of each antibiotic were determined with the epsilometer test (E-test). Resistance genes/mutations were first screened by PCR and analysed by subsequent DNA sequencing. Read More

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http://dx.doi.org/10.1099/jmm.0.000890DOI Listing
February 2019
3 Reads

Determinants of sporadic infections in Denmark: a nationwide case-control study among children and young adults.

Clin Epidemiol 2018 21;10:1695-1707. Epub 2018 Nov 21.

Infectious Disease Epidemiology & Prevention, Statens Serum Institut, Copenhagen, Denmark,

Background: Each year more than 4,000 cases of campylobacteriosis are reported in Denmark, making it the most common bacterial gastrointestinal infection. Here we describe a case-control study to identify sources of infection with a focus on environmental factors.

Methods: From January to December 2016, we conducted a prospective case-control study among Danish persons aged 1-30 years. Read More

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http://dx.doi.org/10.2147/CLEP.S177141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255050PMC
November 2018
1 Read

Ciprofloxacin resistance among Campylobacter jejuni isolates obtained from shelter dogs in Texas.

Zoonoses Public Health 2019 05 9;66(3):337-342. Epub 2018 Dec 9.

Texas A&M University, College Station, Texas.

There are few epidemiologic studies on the shedding of Campylobacter among dogs in the United States, despite the potential public health implications. Our objectives were to estimate the prevalence of faecal Campylobacter shedding among Texas shelter dogs as detected by culture methods and to characterize the isolates by species and antimicrobial susceptibility. Using a cross-sectional study design, faecal samples were collected from 185 dogs in six animal shelters throughout Texas between May and December 2014. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/zph.12544
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http://dx.doi.org/10.1111/zph.12544DOI Listing
May 2019
21 Reads
2.065 Impact Factor

Impact of pre-travel consultation on clinical management and outcomes of travelers' diarrhea: a retrospective cohort study.

Trop Dis Travel Med Vaccines 2018 4;4:16. Epub 2018 Dec 4.

1Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 USA.

Background: International travelers are at high risk of acquiring travelers' diarrhea. Pre-travel consultation has been associated with lower rates of malaria, hepatitis, and human immunodeficiency virus (HIV) infections. The objective was to study the impact of pre-travel consultation on clinical management and outcomes of travelers' diarrhea. Read More

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http://dx.doi.org/10.1186/s40794-018-0076-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280521PMC
December 2018

Campylobacter Concisus and Its Effect on the Expression of CDX1 and COX2

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3211-3216. Epub 2018 Nov 29.

Department of Microbiology of Pathobiology, School of Public Health, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran.

Background: Barrett’s oesophagus (BO) is a pre-malignant condition in which normal squamous epithelium of the lower oesophagus and gastresophageal junction is replaced by columnar cells and progress to oesophageal adenocarcinoma. The increase burden of oesophagus cancer morbidity and mortality worldwide make study of factors involved in the pathogenesis of BO essential. However, most of studies that examine the environmental risk factors associated with increased incidence and prevalence of BO have largely ignored the potential role of bacteria in disease aetiology. Read More

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http://dx.doi.org/10.31557/APJCP.2018.19.11.3211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318391PMC
November 2018
2 Reads

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields.

J Basic Microbiol 2019 Feb 28;59(2):123-133. Epub 2018 Nov 28.

Department of Zoology, Abdul Wali Khan University, Garden Campus, Mardan, Pakistan.

Bacteriophages (phages/viruses) need host bacteria to replicate and propagate. Primarily, a bacteriophage contains a head/capsid to encapsidate the genetic material. Some phages contain tails. Read More

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http://dx.doi.org/10.1002/jobm.201800412DOI Listing
February 2019
20 Reads
1.823 Impact Factor

The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.

J Cell Physiol 2019 Jun 27;234(6):8550-8569. Epub 2018 Nov 27.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible mechanisms, such as visceral hypersensitivity, irregular gut motility, abnormal brain-gut relations, and the role of infectious agents, are implicated in initiation and development of this syndrome. Read More

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http://doi.wiley.com/10.1002/jcp.27828
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http://dx.doi.org/10.1002/jcp.27828DOI Listing
June 2019
21 Reads
3.839 Impact Factor

Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production.

Vet Microbiol 2018 Dec 9;227:112-118. Epub 2018 Aug 9.

Vaccine & Molecular Innovation RPT, University of Southern Queensland, Toowoomba, Australia. Electronic address:

Spotty Liver Disease is an acute infectious disease of layer chickens that was likely first described in the USA and Canada in the 1950s and 1960's. The disease occurs almost exclusively in barn and free-range production systems. Outbreaks usually, but not exclusively occur in young layers (≅25 weeks) at peak of lay. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.08.004DOI Listing
December 2018
2 Reads

A retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina).

Prev Vet Med 2018 Dec 29;161:109-114. Epub 2018 Oct 29.

Department of Animal Production, School of Veterinary, University of Cordoba, 14071, Spain.

The venereal diseases bovine trichomoniasis (BT) and bovine genital campylobacteriosis (BGC) cause economic losses in endemic areas like La Pampa province in Argentina, where beef cattle are usually managed extensively. The eradication of both diseases is a priority in Argentine. The aim of this case-control study was to identify shared and specific risk factors of both diseases from the data obtained from the Provincial Program for the Control and Eradication of BT and BGC in La Pampa (PCE). Read More

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http://dx.doi.org/10.1016/j.prevetmed.2018.10.022DOI Listing
December 2018
10 Reads

Do humans spread zoonotic enteric bacteria in Antarctica?

Sci Total Environ 2019 Mar 23;654:190-196. Epub 2018 Oct 23.

Institut de Recerca de la Biodiversitat (IRBio) and Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Universitat de Barcelona, 08028 Barcelona, Spain.

Reports of enteric bacteria in Antarctic wildlife have suggested its spread from people to seabirds and seals, but evidence is scarce and fragmentary. We investigated the occurrence of zoonotic enteric bacteria in seabirds across the Antarctic and subantarctic region; for comparison purposes, in addition to seabirds, poultry in a subantarctic island was also sampled. Three findings suggest reverse zoonosis from humans to seabirds: the detection of a zoonotic Salmonella serovar (ser. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.272DOI Listing
March 2019
1 Read

Antibiotic Resistance of Species in a Pediatric Cohort Study.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

The objective of this study was to determine the phenotypic patterns of antibiotic resistance and the epidemiology of drug-resistant spp. from a low-resource setting. A birth cohort of 303 patients was followed until 5 years of age. Read More

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http://dx.doi.org/10.1128/AAC.01911-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355604PMC
February 2019
15 Reads
4.480 Impact Factor

Guillain-Barré syndrome post renal transplant: A systematic review.

Transpl Infect Dis 2019 Feb 28;21(1):e13021. Epub 2018 Nov 28.

Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, NSW, Australia.

Background: Guillain-Barré syndrome (GBS) is a common ascending polyneuropathy in adults. It is often associated with preceding viral or diarrhoeal illness with cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Campylobacter jejuni. Solid organ transplant recipients are more susceptible to opportunistic infections with CMV than the general population as a result of immunosuppressive therapies to prevent graft rejection. Read More

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http://doi.wiley.com/10.1111/tid.13021
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http://dx.doi.org/10.1111/tid.13021DOI Listing
February 2019
14 Reads

A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.

NPJ Vaccines 2018 31;3:53. Epub 2018 Oct 31.

1Department of Respiratory Medicine, Centre for Inflammation and Tissue Repair, University College London, London, UK.

The pneumococcal conjugate vaccine (PCV) strongly protects against vaccine serotypes, but the rapid expansion of non-vaccine serotype disease and the vaccine's high expense has reduced its overall impact. We have developed Protein Glycan Coupling Technology (PGCT) as a flexible methodology for making low-cost polysaccharide/protein glycoconjugates recombinantly in . We have used PGCT to make a recombinant PCV containing serotype 4 capsular polysaccharide linked to the proteins NanA, PiuA, and Sp0148. Read More

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http://www.nature.com/articles/s41541-018-0090-4
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http://dx.doi.org/10.1038/s41541-018-0090-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208403PMC
October 2018
7 Reads