659,979 results match your criteria California Fish And Game[Journal]


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

DNA methylation acts at the interface of genetic and environmental factors relevant for autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child. Here, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) of high-risk pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz084DOI Listing

National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/M19-0961DOI Listing

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana (J.W.A., K.M.G.).

Background: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.

Objective: To identify some predictors of LTWL.

Design: The DPP (Diabetes Prevention Program) was a randomized controlled trial that compared weight loss with metformin, intensive lifestyle intervention (ILS), or placebo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/M18-1605DOI Listing

Can We Pave the Pathway to Fracture Prevention?

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California (C.J.C.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/M19-1112DOI Listing

Microdermal Implants Show No Effect on Surrounding Tissue During Surgery With Electrocautery.

J Surg Res 2019 Apr 19;241:72-77. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington.

Background: Microdermal implants are an increasingly popular form of body jewelry. The potential for electrical conduction burn at the site of metal jewelry left in situ during electrosurgery has prompted surgical societies to recommend routine removal before surgery. To date, however, there is a lack of evidence to support this practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.03.039DOI Listing

Corrigendum to "The moderating effect of perceived social support on the relation between heaviness of smoking and quit attempts among adult homeless smokers" [Drug and Alcohol Depend. 190 (2018) 128-132].

Drug Alcohol Depend 2019 Apr 19;199:69. Epub 2019 Apr 19.

The University of Oklahoma Health Sciences Center, Oklahoma Tobacco Research Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2019.04.003DOI Listing

Corrigendum to "Concurrent nicotine and tobacco product use among homeless smokers and associations with cigarette dependence and other factors related to quitting" [Drug Alcohol Depend. 185 (2018) 133-140].

Drug Alcohol Depend 2019 Apr 19;199:68. Epub 2019 Apr 19.

Oklahoma Tobacco Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2019.04.002DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
Publisher Site
http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
1 Read

Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Boston Children's Hospital, Boston, MA. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) is commonly used to treat Clostridium difficile infection (CDI). CDI is an increasing cause of diarrheal illness in pediatric patients, but the effects of FMT have not been well studied in children. We performed a multi-center retrospective cohort study of pediatric and young adult patients to evaluate the efficacy, safety, and factors associated with a successful FMT for the treatment of CDI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2019.04.037DOI Listing

Spatial Patterns From High-Resolution Electrogastrography Correlate With Severity of Symptoms in Patients With Functional Dyspepsia and Gastroparesis.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

GI Innovation Group, University of California-San Diego, La Jolla, CA, USA; GI Motility & Physiology Program, University of California-San Diego, La Jolla, CA, USA. Electronic address:

Background & Aims: Invasive gastric electrical mapping has revealed spatial abnormalities of the slow wave in subjects with gastroparesis and functional gastrointestinal disorders. Cutaneous high-resolution electrogastrography (HR-EGG) is a non-invasive method that can detect spatial features of the gastric slow wave. We performed HR-EGG in subjects with active foregut symptoms to evaluate associations between gastric myoelectric abnormalities, symptoms (based on a validated questionnaire), and gastric emptying. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2019.04.039DOI Listing

Should We Divide Crohn's Disease Into Ileum-dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

University of California San Diego, La Jolla CA.

Crohn's disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing

Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California; Palo Alto Veterans Affairs Health Care System, Palo Alto, California. Electronic address:

Background: There is a lack of literature guiding treatment of giant cell glioblastoma (gcGBM), a rare subtype of glioblastoma (GBM). We used a national hospital-based registry to explore treatment patterns and outcomes associated with gcGBM.

Methods: Adult patients (age 18+) diagnosed with gcGBM or GBM between 2004-2014 were identified from the National Cancer Database (NCDB). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750193109
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2019.04.103DOI Listing
April 2019
1 Read

Urinary and Sexual Outcomes following Bulbar Urethroplasty - An Analysis of Two Common Approaches.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Clinical Professor of Urology, University of California - Irvine, Department of Urology, 333 City Blvd West, Suite 1240, Orange, CA 92868. Electronic address:

Objective: To report success and patient reported urinary and sexual outcomes of patients who underwent anastomotic urethroplasty and dorsal buccal onlay urethroplasty.

Materials And Methods: Patients who underwent primary transecting anastomotic or dorsal buccal onlay urethroplasty for bulbar strictures at our institution between 1998 and 2015 were analyzed. Patients who had a prior urethroplasty, involvement of a different portion of the urethra, or a diagnosis of LS or hypospadias were excluded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2019.02.042DOI Listing

A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

Thrombolysis for Management of Phlegmasia Cerulea Dolens in the First Trimester of Pregnancy.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2019.01.018DOI Listing

Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Pediatric Pneumology and Allergology unit, Necker-Enfants Malades Hospital, Paris, France; Université Paris Descartes, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.04.011DOI Listing

Experience-dependent mechanisms in the regulation of parental care.

Front Neuroendocrinol 2019 Apr 19. Epub 2019 Apr 19.

University of California, Davis, Department of Psychology, One Shields Ave. Davis, CA 95616.

Maternal behavior is a defining characteristic of mammals, which is regulated by a core, conserved neural circuit. However, mothering behavior is not always a default response to infant conspecifics. For example, initial fearful, fragmented or aggressive responses toward infants in laboratory rats and mice can give way to highly motivated and organized caregiving behaviors following appropriate hormone exposure or repeated experience with infants. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00913022183012
Publisher Site
http://dx.doi.org/10.1016/j.yfrne.2019.04.002DOI Listing
April 2019
1 Read

Blunt Curettage for Post-Operative Hematomas.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, University of California, Davis, Sacramento.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.04.031DOI Listing

Validation and interpretation of short form 12 and comparison with dermatology life quality index in atopic dermatitis in adults.

J Invest Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Oregon Health & Science University, Portland, OR.

Quality of life (QOL) assessments are not standardized in atopic dermatitis (AD). We sought to determine the validity of Short-Form 12 (SF-12), a generic QOL assessment, in AD and compare its measurement properties with Dermatology Life Quality Index (DLQI). A cross-sectional, population-based study of 3495 adults was performed, including 602 that met a modified UK Working Party Criteria for AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.03.1152DOI Listing

Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans.

J Trauma Stress 2019 Apr;32(2):226-237

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

We developed an algorithm for identifying U.S. veterans with a history of posttraumatic stress disorder (PTSD), using the Department of Veterans Affairs (VA) electronic medical record (EMR) system. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jts.22399
Publisher Site
http://dx.doi.org/10.1002/jts.22399DOI Listing
April 2019
1 Read

Gender-Stratified Prevalence of Psychiatric and Pain Diagnoses in a Primary Care Patient Sample with Fibromyalgia.

Pain Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Family and Community Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Objective: Comorbid psychiatric and pain-related conditions are common in patients with fibromyalgia. Most studies in this area have used data from patients in specialty care and may not represent the characteristics of fibromyalgia in primary care patients. We sought to fill gaps in the literature by determining if the association between psychiatric diagnoses, conditions associated with chronic pain, and fibromyalgia differed by gender in a primary care patient population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/pm/pnz084DOI Listing

Relative Performance and Impacts of the Psyllid Arytinnis hakani (Hemiptera: Psyllidae) on Nontarget Plants and the Target Weed Genista monspessulana (Fabales: Fabaceae).

Environ Entomol 2019 Apr 22. Epub 2019 Apr 22.

Invasive Species and Pollinator Health Research Unit, USDA-ARS, Albany, CA.

No-choice tests can help select weed biological control agents with a high degree of host specificity but may exclude potentially effective agents that can develop on nontarget plants under laboratory conditions. The actual amount of damage to nontarget plants often goes unstudied, even though agents may exploit nontarget plants without inflicting significant harm. Furthermore, tests typically assess whether prospective agents can complete one generation on nontarget plants, and rarely examine whether agents are likely to persist on the nontarget plants over the long term. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ee/nvz041DOI Listing

Confidence boosts serial dependence in orientation estimation.

J Vis 2019 Apr;19(4):25

University of Wisconsin-Madison, Department of Psychology and Department of Psychiatry, Madison, WI.

In the absence of external feedback, a decision maker must rely on a subjective estimate of their decision accuracy in order to appropriately guide behavior. Normative models of perceptual decision-making relate subjective estimates of internal signal quality (e.g. Read More

View Article

Download full-text PDF

Source
http://jov.arvojournals.org/article.aspx?doi=10.1167/19.4.25
Publisher Site
http://dx.doi.org/10.1167/19.4.25DOI Listing
April 2019
1 Read

Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.

PLoS One 2019 22;14(4):e0215378. Epub 2019 Apr 22.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Objective: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215378PLOS
April 2019
1 Read

Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm.

PLoS Comput Biol 2019 Apr 22;15(4):e1006842. Epub 2019 Apr 22.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America.

Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006842DOI Listing

A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation.

PLoS Comput Biol 2019 Apr 22;15(4):e1006534. Epub 2019 Apr 22.

Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland.

Bacterial populations that colonize a host can play important roles in host health, including serving as a reservoir that transmits to other hosts and from which invasive strains emerge, thus emphasizing the importance of understanding rates of acquisition and clearance of colonizing populations. Studies of colonization dynamics have been based on assessment of whether serial samples represent a single population or distinct colonization events. With the use of whole genome sequencing to determine genetic distance between isolates, a common solution to estimate acquisition and clearance rates has been to assume a fixed genetic distance threshold below which isolates are considered to represent the same strain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006534DOI Listing

BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data.

PLoS Comput Biol 2019 Apr 22;15(4):e1006971. Epub 2019 Apr 22.

Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Genome-scale metabolic models (GEMs) are mathematically structured knowledge bases of metabolism that provide phenotypic predictions from genomic information. GEM-guided predictions of growth phenotypes rely on the accurate definition of a biomass objective function (BOF) that is designed to include key cellular biomass components such as the major macromolecules (DNA, RNA, proteins), lipids, coenzymes, inorganic ions and species-specific components. Despite its importance, no standardized computational platform is currently available to generate species-specific biomass objective functions in a data-driven, unbiased fashion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006971DOI Listing

Machine Learning and Deep Neural Networks in Thoracic and Cardiovascular Imaging.

J Thorac Imaging 2019 May;34(3):192-201

Department of Radiology, University of California San Diego.

Advances in technology have always had the potential and opportunity to shape the practice of medicine, and in no medical specialty has technology been more rapidly embraced and adopted than radiology. Machine learning and deep neural networks promise to transform the practice of medicine, and, in particular, the practice of diagnostic radiology. These technologies are evolving at a rapid pace due to innovations in computational hardware and novel neural network architectures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RTI.0000000000000385DOI Listing

Assessment of Resistance in Potato Cultivars to Verticillium Wilt Caused by and .

Plant Dis 2019 Apr 19:PDIS10181815RE. Epub 2019 Apr 19.

4 Department of Plant Pathology, University of California, Davis, Salinas, CA 93905, U.S.A.

Verticillium wilt caused by spp., also called potato early dying disease, is one of the most serious soilborne diseases affecting potato production in China. The disease has been expanding into most potato production areas over the past few years. Read More

View Article

Download full-text PDF

Source
https://apsjournals.apsnet.org/doi/10.1094/PDIS-10-18-1815-R
Publisher Site
http://dx.doi.org/10.1094/PDIS-10-18-1815-REDOI Listing
April 2019
1 Read

Intracranial Atherosclerotic Disease.

Stroke 2019 May;50(5):1286-1293

Department of Neurology, Neurovascular Imaging Research Core and UCLA Stroke Center, University of California at Los Angeles (D.S.L.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.024147DOI Listing

Arteriopathy Influences Pediatric Ischemic Stroke Presentation, but Sickle Cell Disease Influences Stroke Management.

Stroke 2019 May;50(5):1089-1094

Departments of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas and Children's Health Dallas (M.M.D.).

Background and Purpose- Sickle cell disease (SCD) and arteriopathy are pediatric stroke risk factors that are not mutually exclusive. The relative contributions of sickled red blood cells and arteriopathy to stroke risk are unknown, resulting in unclear guidelines for primary and secondary stroke prevention when both risk factors are present. We hypothesized that despite similarities in clinical presentation and radiographic appearance of arteriopathies, stroke evaluation and management differ in children with SCD compared with those without SCD. Read More

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.022800
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.118.022800DOI Listing
May 2019
1 Read

Enhancing Natural Killer and CD8 T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 T Cells with HLA-E Monospecific Monoclonal Antibodies.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):38-59

4 Department of Pediatrics and Pathology, Children's Hospital, Keck School of Medicine, USC, Los Angeles, California.

Cytotoxic NK/CD8 T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A. The NK/CD8 T cell cytotoxic capability is lost when tumor-associated human leukocyte antigen, HLA-E, binds the CD94/NKG2A receptor, resulting in tumor progression and reduced survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mab.2018.0043DOI Listing

Understandability and Actionability of Online Information on Hypertension.

Popul Health Manag 2019 Apr 22. Epub 2019 Apr 22.

2 Practice Management Board, University of California Davis Health, Sacramento, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/pop.2019.0037DOI Listing

Financial Margins for Prostate Cancer Surgery: Quantifying the Impact of Modifiable Cost Inputs in an Episode-based Reimbursement Model.

J Urol 2019 Apr 22:101097JU0000000000000283. Epub 2019 Apr 22.

Department of Urology, David Geffen School of Medicine at UCLA , Los Angeles , CA .

Purpose: The United States health care system is rapidly moving away from fee-for-service reimbursement in an effort to improve quality and contain costs. Episode-based reimbursement is an increasingly relevant value-based payment model for surgical care. The authors sought to quantify the impact of modifiable cost inputs on institutional financial margins in an episode-based payment model for prostate cancer surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JU.0000000000000283DOI Listing

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1289/EHP3971DOI Listing

Telemedicine for medical abortion - Time to move toward broad implementation.

Authors:
Daniel Grossman

BJOG 2019 Apr 22. Epub 2019 Apr 22.

Advancing New Standards in Reproductive Health (ANSIRH), Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, Oakland, CA.

The systematic review by Endler, et al. (Endler et al. BJOG, 2019 xxxx) provides reassuring evidence from a range of settings that telemedicine provision of medical abortion is safe, effective, and well-liked by patients and providers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15802DOI Listing

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A, a key cytokine involved in psoriasis (PsO) and psoriatic arthritis (PsA) development, and has shown rapid and long lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Monoclonal antibody therapies may be associated with the production of treatment-emergent anti-drug antibodies (TE-ADA) that can affect drug pharmacokinetics, diminish clinical responses via inhibition of target binding, or cause hypersensitivity reactions. Secukinumab exhibited minimal immunogenicity up to 52 weeks in patients with moderate-to-severe plaque psoriasis, as evidenced by TE-ADA in <1% patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15637DOI Listing

In Vitro Resistance Profile of Hepatitis C Virus NS5A Inhibitor Velpatasvir in Genotypes 1 to 6.

J Viral Hepat 2019 Apr 22. Epub 2019 Apr 22.

Gilead Sciences, Foster City, California, USA.

Velpatasvir is a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor which is used with sofosbuvir for treatment of infection with HCV genotypes 1 to 6. In vitro resistance studies were performed to characterize NS5A changes that might also confer reduced velpatasvir susceptibility in vivo. Resistance selection studies using HCV replicon cells for subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a identified NS5A resistance-associated substitutions (RASs) at nine positions, most often 28M/S/T, 31F/I/M/P/V and 93D/H/N/S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvh.13116DOI Listing

N-Methyl-d-aspartate receptor open-channel blockers memantine and magnesium modulate nociceptive trigeminovascular neurotransmission in rats.

Eur J Neurosci 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Experimental and clinical studies suggest that the low-affinity N-methyl-d-aspartate (NMDA) receptor open-channel blockers Mg and memantine are effective in reducing trigeminal nociceptive activation. The aim of the present study was to investigate the apparent effectiveness of these channel blockers using a model of trigeminal activation in vivo. Rats were anesthetized before electrically stimulating the dura mater adjacent the middle meningeal artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14423DOI Listing

Using a surrogate marker for early testing of a treatment effect.

Biometrics 2019 Apr 22. Epub 2019 Apr 22.

Stanford University, Department of Biomedical Data Science, Stanford, California, U.S.A.

The development of methods to identify, validate and use surrogate markers to test for a treatment effect has been an area of intense research interest given the potential for valid surrogate markers to reduce the required costs and follow-up times of future studies. Several quantities and procedures have been proposed to assess the utility of a surrogate marker. However, few methods have been proposed to address how one might use the surrogate marker information to test for a treatment effect at an earlier time point, especially in settings where the primary outcome and the surrogate marker are subject to censoring. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13067
Publisher Site
http://dx.doi.org/10.1111/biom.13067DOI Listing
April 2019
1 Read

Confronting My Bias.

Authors:
Megan B Richie

JAMA Neurol 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurology, University of California at San Francisco, San Francisco.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2019.0841DOI Listing

One-Year Mortality After Dialysis Initiation Among Older Adults.

JAMA Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamainternmed.2019.0125DOI Listing

Association of Cumulative Socioeconomic and Health-Related Disadvantage With Disparities in Smoking Prevalence in the United States, 2008 to 2017.

JAMA Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles.

Importance: Understanding emerging patterns of smoking disparities among disadvantaged populations can guide tobacco control policy.

Objective: To estimate disparities in smoking prevalence associated with the number of socioeconomic and health-related disadvantages faced by a population among US adults from 2008 to 2017.

Design, Setting, And Participants: Nationally representative cross-sectional annual household-based probability sample of US noninstitutionalized residents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamainternmed.2019.0192DOI Listing

Framework for the Creation of Ethical and Professional Social Media Content.

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Oklahoma City, Oklahoma.

Background: Social Media is a powerful tool that allows users to communicate directly with an online community. Plastic surgeons were early adopters of social media, recognizing its educational and marketing potential. With the use of social media come ethical and legal concerns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005782DOI Listing

Opioid-prescribing Outcomes of Medicare Beneficiaries Managed by Nurse Practitioners and Physicians.

Med Care 2019 Apr 18. Epub 2019 Apr 18.

The Heller School, Brandeis University, Waltham, MA.

Background: Primary care providers are at the center of the opioid epidemic. Whether nurse practitioners (NPs) have different opioid-prescribing outcomes from physicians is not known.

Objective: To examine opioid-prescribing outcomes of Medicare beneficiaries receiving care from NPs and physicians in primary care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MLR.0000000000001126DOI Listing

Rationale for Biologic Augmentation of Rotator Cuff Repairs.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Orthopaedic Surgery, Southern California Permanent Medical Group, Baldwin Park, CA (Dr. Mirzayan), the Division of Sports Medicine, Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA (Dr. Weber, Dr. Petrigliano), and the Sports Medicine and Shoulder Division, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL (Dr. Chahla).

The structural integrity of rotator cuff repair (RCR) has been a primary focus for shoulder surgeons seeking long-term clinical and functional success. Improvements in surgical techniques have allowed for superior initial biomechanical fixation. However, tendon healing remains a significant clinical problem even after rigid time-zero repair. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5435/JAAOS-D-18-00281DOI Listing

Race/Ethnicity-specific Disparities in In-Hospital Mortality and Hospital Charges Among Inflammatory Bowel Disease-related Hospitalizations in the United States.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA.

Goal: The goal of this study was to evaluate disparities in hospital outcomes among inflammatory bowel disease (IBD) related hospitalizations in the United States with a focus on ethnicity-specific disparities.

Background: IBD-related hospitalizations contribute to significant morbidity and health care economic burden.

Methods: IBD-related hospitalizations (identified with ICD-9) among US adults were evaluated using 2007 to 2013 Nationwide Inpatient Sample. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004836-900000000-9773
Publisher Site
http://dx.doi.org/10.1097/MCG.0000000000001204DOI Listing
April 2019
1 Read

Serological Markers for Syphilis Among Persons Presenting with Syndromes Associated with Sexually Transmitted Infections Results from the Zimbabwe STI Etiology Study.

Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington School of Medicine, Seattle, WA, USA.

Background: Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/OLQ.0000000000001006DOI Listing

Nurse Staffing and Healthcare-Associated Infection, Unit-Level Analysis.

J Nurs Adm 2019 May;49(5):260-265

Author Affiliations: Associate Professor (Dr Shang), Assistant Professor of Quantitative Research (Dr Liu), Professor and Associate Dean for Research (Dr Larson), Professor and Director of Center for Health Policy (Dr Stone), School of Nursing, Columbia University, New York; and Professor and Chair (Dr. Needleman), Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, California.

Objective: To examine whether healthcare-associated infections (HAIs) and nurse staffing are associated using unit-level staffing data.

Background: Previous studies of the association between HAIs and nurse staffing are inconsistent and limited by methodological weaknesses.

Methods: Cross-sectional data between 2007 and 2012 from a large urban hospital system were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NNA.0000000000000748DOI Listing
  • Page 1 of 13200