715,438 results match your criteria California Fish And Game[Journal]


Ethical Framework for Nutrition Support Resource Allocation During Shortages: Lessons From COVID-19.

Nutr Clin Pract 2020 Jun 3. Epub 2020 Jun 3.

Didactic Program in Dietetics, Department of Nutrition Food Studies, New York University/Steinhardt, New York, New York, USA.

The coronavirus disease (COVID-19) pandemic has impacted all aspects of our population. The "Troubling Trichotomy" of what can be done technologically, what should be done ethically, and what must be done legally is a reality during these unusual circumstances. Recent ethical considerations regarding allocation of scarce resources, such as mechanical ventilators, have been proposed. Read More

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http://dx.doi.org/10.1002/ncp.10500DOI Listing

SlBL4 regulates chlorophyll accumulation, chloroplast development and cell wall metabolism in tomato fruit.

J Exp Bot 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, Chongqing University, Chongqing, China.

Tomato is a model for studying the climate for fruit development and ripening. Down-regulation of a tomato bell-like homeodomain 4 (SlBL4) resulted in a slightly darker green fruit phenotype and increased accumulation of starch, fructose and glucose. Chlorophyll content analysis and TEM observation confirmed these phenotypes, indicating that SlBL4 was involved in the chlorophyll accumulation and chloroplast formation in tomato. Read More

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http://dx.doi.org/10.1093/jxb/eraa272DOI Listing

Phenotypic and Functional Analysis of T Follicular Cells in Common Variable Immunodeficiency.

Int Arch Allergy Immunol 2020 Jun 3:1-13. Epub 2020 Jun 3.

Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, California, USA.

Introduction: One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study was to evaluate the role of circulating T follicular helper (cTFH) and circulating T follicular regulatory (cTFR) cells in the pathogenesis of CVID.

Methods: cTFH and cTFR cells from CVID patients and healthy subjects were phenotypically characterized by flow cytometry. Read More

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http://dx.doi.org/10.1159/000507995DOI Listing

Optimizing neuromodulation based on surrogate neural states for seizure suppression in a rat temporal lobe epilepsy model.

J Neural Eng 2020 Jun 3. Epub 2020 Jun 3.

Neurosurgery, Emory University, Atlanta, Georgia, UNITED STATES.

Objective: Developing a new neuromodulation method for epilepsy treatment requires a large amount of time and resources to find effective stimulation parameters and often fails due to inter-subject variability in stimulation effect. As an alternative, we present a novel data-driven surrogate approach which can optimize the neuromodulation efficiently by investigating the stimulation effect on surrogate neural states.

Approach: Medial septum (MS) optogenetic stimulation was applied for modulating electrophysiological activities of the hippocampus in a rat temporal lobe epilepsy model. Read More

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http://dx.doi.org/10.1088/1741-2552/ab9909DOI Listing

Digest.

J Sport Exerc Psychol 2020 Jun 3:1-4. Epub 2020 Jun 3.

California State University, Fullerton, USA.

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http://dx.doi.org/10.1123/jsep.2020-0091DOI Listing

Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists.

Eur J Med Chem 2020 May 16;200:112410. Epub 2020 May 16.

Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. Electronic address:

CXCR4, a well-studied coreceptor of human immunodeficiency virus type 1 (HIV-1) entry, recognizes its cognate ligand SDF-1α (also named CXCL12) which plays many important roles, including regulating immune cells, controlling hematopoietic stem cells, and directing cancer cells migration. These pleiotropic roles make CXCR4 an attractive target to mitigate human disorders. Here a new class of symmetrical polyamines was designed and synthesized as potential small molecule CXCR4 antagonists. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112410DOI Listing

Photochemical transformation of perfluoroalkyl acid precursors in water using engineered nanomaterials.

Water Res 2020 May 20;181:115964. Epub 2020 May 20.

Department of Environmental Science & Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address:

The production of perfluoroalkyl acids (PFAAs) has been phased out over recent decades; however, no significant decline in their environmental concentrations has been observed. This is partly due to the photochemical decomposition of PFAAs precursors (PrePFAAs) which remain in extensive use. The decomposition of PrePFAAs may be accelerated by the light-activated engineered nanomaterials (ENMs) in water. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115964DOI Listing

Associations Between Food Insecurity and Parental Feeding Behaviors of Toddlers.

Acad Pediatr 2020 May 31. Epub 2020 May 31.

Department of Pediatrics and Duke Center for Childhood Obesity Research, Duke University School of Medicine; 2213 Elba Street, Durham, NC 27705. Electronic address:

Objectives: We examined associations between household food insecurity status and parental feeding behavior, weight perception, and child weight status in a diverse sample of young children.

Methods: Cross-sectional analysis of 2-year old children in Greenlight, a cluster randomized trial to prevent childhood obesity. The exposure was food insecurity, defined as a positive response to a validated screen. Read More

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http://dx.doi.org/10.1016/j.acap.2020.05.020DOI Listing

Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria.

Papillomavirus Res 2020 May 31:100200. Epub 2020 May 31.

University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Anal precancers and cancers can be detected during screening with high-resolution anoscopy (HRA). The sensitivity of HRA depends on the burden and duration of human papillomavirus (HPV) among those screened as well as anoscopist proficiency, which is highly correlated with prior screening experience. Our objective was to compare the identification and type of HPV and the likelihood of HRA-detected precancer for men who have sex with men (MSM) undergoing their first HRA-screening in Nigeria. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100200DOI Listing

Compaction conditions affect the capacity of biochar-amended sand filters to treat road runoff.

Sci Total Environ 2020 May 20;735:139180. Epub 2020 May 20.

Department of Civil and Environmental Engineering, University of California, Los Angeles, USA. Electronic address:

Amending roadside soil with adsorbents such as biochar can help remove pollutants from road runoff. To maintain soil stability, the roadside soil requires compaction. However, it is unknown how compaction conditions affect the capacity of biochar-augmented roadside biofilters to infiltrate stormwater and remove pollutants. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139180DOI Listing

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.

Cell Rep 2020 Jun;31(9):107716

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases and 166,145 controls from 70 ancestry-specific cohorts and identify 18 significant GReX-PTSD associations corresponding to specific tissue-gene pairs. The results suggest substantial genetic heterogeneity based on ancestry, cohort type (military versus civilian), and sex. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107716DOI Listing

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.

Cell Rep 2020 Jun;31(9):107715

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Previous studies have suggested that the loss of the translation initiation factor eIF4G1 homolog NAT1 induces excessive self-renewability of naive pluripotent stem cells (PSCs); yet the role of NAT1 in the self-renewal and differentiation of primed PSCs is still unclear. Here, we generate a conditional knockout of NAT1 in primed PSCs and use the cells for the functional analyses of NAT1. Our results show that NAT1 is required for the self-renewal and neural differentiation of primed PSCs. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107715DOI Listing

Ketone Bodies Exert Ester-Ordinary Suppression of Bifidobacteria and Th17 Cells.

Cell Metab 2020 Jun;31(6):1049-1051

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

The ketogenic diet is used to treat neurological and metabolic symptoms of disease, but the extent of its influences across organ systems remains unclear. Ang et al., 2020 reveal that ketone bodies induced by the diet inhibit specific bacteria of the gut microbiota and suppress pro-inflammatory T cells in the intestine. Read More

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http://dx.doi.org/10.1016/j.cmet.2020.05.011DOI Listing

Need to Amplify Health Security? Fuse Academia and Practice.

Public Health Rep 2020 Jun 3:33354920935075. Epub 2020 Jun 3.

438446 RTI International, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1177/0033354920935075DOI Listing

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Vanderbilt University Medical Center, 12328, Emergency Medicine, Nashville, Tennessee, United States.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale and background for the trial and highlights key design features. We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202005-478SDDOI Listing

Coordination of Uranyl to the Redox-Active Calix[4]pyrrole Ligand.

Inorg Chem 2020 Jun 3. Epub 2020 Jun 3.

Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.

Reaction of [Li(THF)][L] (L = Me-calix[4]pyrrole]) with 0.5 equiv of [UOCl(THF)] results in formation of the oxidized calix[4]pyrrole product, [Li(THF)][L] (), concomitant with formation of reduced uranium oxide byproducts. Complex can also be generated by reaction of [Li(THF)][L] with 1 equiv of I. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c01224DOI Listing

Using GIS Mapping to Track Hot Spots of Kidney Disease in California.

N Engl J Med 2020 06;382(23):2265-2267

University of Connecticut, Groton, CT.

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http://dx.doi.org/10.1056/NEJMc2001023DOI Listing

Cardiovascular Consequences of Acute Kidney Injury.

N Engl J Med 2020 06;382(23):2238-2247

From the Department of Anesthesiology and Perioperative Care, University of California, San Francisco, San Francisco (M.L.); and INSERM 942, Lariboisière Hospital, and French Clinical Research Infrastructure Network, Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (F-CRIN INI-CRCT), Paris (M.L.), and Université de Lorraine, INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM Unité 1116, Centre Hospitalier Régional Universitaire (CHRU) de Nancy, and F-CRIN INI-CRCT, Nancy (P.R.) - all in France.

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http://dx.doi.org/10.1056/NEJMra1916393DOI Listing

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.

N Engl J Med 2020 06;382(23):2207-2219

From the Departments of Pediatric and Adolescent Oncology (V.M.-C., C.P.) and Clinical Research (G.V.), INSERM Unité 1015 (V.M.-C.), and the Unit of Biostatistics and Epidemiology and INSERM Unité 1018 (A.A.), Gustave Roussy, Université Paris-Saclay, Villejuif, France; the Department of Pediatric Hematology and Oncology, University of Padua, Padua, Italy (M.P.); the Department of Paediatric Haematology, Oncology, and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (G.A.A.B.), Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham (K.W.), and the Department of Histopathology, Royal Marsden NHS Foundation Trust, London (A.W.) - all in the United Kingdom; the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (D.A.B.); the Department of Pediatric Hematology and Oncology, University of Valencia, Valencia, Spain (R.F.D.); the Division of Haematology-Oncology, Hospital for Sick Children, Toronto (S.A.); the Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium (A.U.); the Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC (C.M.B.); Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands (J.Z.); the Department of Pediatric Hematology and Oncology, Semmelweis University, Budapest, Hungary (M.C.); the Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland (B.K.); the Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong (A.K.C.); the Department of Pathology, University of Utah, Salt Lake City (R.R.M.); Children's Hospital of Philadelphia, Philadelphia (P.C.A.); and the National Cancer Institute, Center for Global Health, Rockville, MD (T.G.G.).

Background: Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.

Methods: We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level or stage IV) or acute leukemia to compare the addition of six doses of rituximab to standard lymphomes malins B (LMB) chemotherapy with standard LMB chemotherapy alone. Read More

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http://dx.doi.org/10.1056/NEJMoa1915315DOI Listing

Lower Prices and Greater Patient Access - Lessons from Germany's Drug-Purchasing Structure.

Authors:
James C Robinson

N Engl J Med 2020 Jun;382(23):2177-2179

From the University of California, Berkeley, School of Public Health, Berkeley.

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http://dx.doi.org/10.1056/NEJMp2000341DOI Listing

Of Heroes and Cowards.

Authors:
Shire Lynn Beach

N Engl J Med 2020 Jun 3. Epub 2020 Jun 3.

From the Department of Internal Medicine, University of California, Los Angeles, Los Angeles.

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http://dx.doi.org/10.1056/NEJMp2013266DOI Listing

Herbicide treatment alters the effects of water hyacinth on larval mosquito abundance.

J Vector Ecol 2020 Jun;45(1):69-81

Department of Entomology and Nematology, University of California, Davis, Davis, CA, 95616, U.S.A.

Invasive aquatic weeds are managed with herbicides to reduce their negative impacts on waterways in many areas, including the California Delta Region. Herbicides create a dynamic environment of living and decomposing plant matter that could affect larval mosquitoes and other invertebrates, such as their predators and competitors. Our objective was to compare the number of larval mosquitoes in water or water hyacinth, before and after an herbicide treatment. Read More

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http://dx.doi.org/10.1111/jvec.12374DOI Listing

Supraclavicular Artery Island Flap: Critical Appraisal and Comparison to Alternate Reconstruction.

Laryngoscope 2020 Jun 3. Epub 2020 Jun 3.

USC Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, California, U.S.A.

Objectives/hypothesis: The supraclavicular artery island (SAI) flap may be a good option for selected head and neck reconstruction due to its reliability, ease of harvest, and favorable color match. The objective of this study was to examine the rates of complications for the SAI flap in head and neck oncologic reconstruction, with examination of risk factors and comparisons to alternative flaps often considered the gold-standard soft-tissue flaps for head and neck reconstruction: the pectoralis myocutaneous (PMC), radial forearm free flap (RFFF), and anterolateral thigh (ALT) flaps.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.28706DOI Listing

VITamin D and OmegA-3 TriaL (VITAL): Effects of Vitamin D Supplements on Risk of Falls in the US Population.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Harvard Medical School, Boston, MA, United States.

Context: It is unclear whether vitamin D supplementation reduces risk of falls, and results from randomized controlled trials (RCTs) are conflicting.

Objective: To determine whether 2000 IU/day of supplemental vitamin D3 decreases fall risk.

Design: VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled RCT including 25,871 adults, randomized November 2011-March 2014 and treated for 5. Read More

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http://dx.doi.org/10.1210/clinem/dgaa311DOI Listing

An Unusual Electrocardiogram Following Pacemaker Implantation.

JAMA Cardiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine, University of California, San Francisco, San Francisco.

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http://dx.doi.org/10.1001/jamacardio.2020.1061DOI Listing

Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

JAMA Psychiatry 2020 Jun 3. Epub 2020 Jun 3.

Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.

Importance: Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent a potentially useful strategy for addressing this global public health problem, but which types of interventions reliably improve immune system function, under what conditions, and for whom are unknown.

Objective: To address this issue, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) in which we estimated associations between 8 different psychosocial interventions and 7 markers of immune system function, and examined 9 potential moderating factors. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.0431DOI Listing

Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.

PLoS One 2020 3;15(6):e0234038. Epub 2020 Jun 3.

Second Genome Inc., South San Francisco, California, United States of America.

Extracellular adenosine triphosphate (eATP) released by damaged cells, and its purinergic receptors, comprise a crucial signaling network after injury. Purinergic receptor P2X7 (P2RX7), a major driver of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and IL-1β processing, has been shown to play a role in liver injury in murine diet- and chemically-induced liver injury models. It is unclear, however, whether P2RX7 plays a role in non-alcoholic steatohepatitis (NASH) and which cell type is the main target of P2RX7 pharmacological inhibition. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234038PLOS

Corrected analysis of 'Using financial incentives to promote physical activity in American Indian adolescents: A randomized controlled trial' confirms conclusions.

PLoS One 2020 3;15(6):e0233273. Epub 2020 Jun 3.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233273PLOS

The effect of early burn injury on sensitivity to future painful stimuli in dairy heifers.

PLoS One 2020 3;15(6):e0233711. Epub 2020 Jun 3.

Center for Animal Welfare, Department of Animal Science, University of California, Davis, California, United States of America.

Animals that experience painful procedures as neonates are more sensitive to pain later in life. We evaluated whether disbudding with a heated iron at 3 (n = 12), 35 (n = 9), or 56 (n = 20) d of age affected heifers' pain responses to vaccine injections at 11 mo of age. Heifers responded to the injection procedure with struggling and changes in eye temperature and heart rate variability compared to a sham procedure the day before, and still had a heightened response 6 d later, regardless of disbudding age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233711PLOS

[Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish].

Mol Biol (Mosk) 2020 May-Jun;54(3):435-444

Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California, San Francisco, CA 94143-2811 USA.

Homology-directed (HD) genome modification offers an opportunity to precisely modify the genome. Despite reported successful cases, for many loci, precise genome editing remains challenging and inefficient in vivo. Here we report an effort to precisely knock-in a GFP reporter into gad locus mediated by CRISPR/Cas9 system in the zebrafish Danio rerio. Read More

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http://dx.doi.org/10.31857/S0026898420030131DOI Listing
February 2019

Salvage Ipilimumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma After Prior Immune Checkpoint Inhibitors.

J Clin Oncol 2020 Jun 3:JCO1903315. Epub 2020 Jun 3.

Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.

Purpose: Immune checkpoint inhibitors (ICIs) are standard therapy in metastatic renal cell carcinoma (RCC). The safety and activity of the combination of ipilimumab and nivolumab in patients who have received prior ICI targeting the programmed death 1 (PD-1) pathway remains unknown. We evaluated ipilimumab and nivolumab in patients with metastatic RCC after prior treatment with anti-PD-1 pathway-targeted therapy. Read More

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http://dx.doi.org/10.1200/JCO.19.03315DOI Listing

Measuring the efficiency of pulmonary gas exchange using expired gas instead of arterial blood: Comparing the "ideal" PO2 of Riley with end-tidal PO2.

Am J Physiol Lung Cell Mol Physiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine and Radiology, University of California, San Diego, United States.

When using a new noninvasive method for measuring the efficiency of pulmonary gas exchange, a key measurement is the oxygen deficit, defined as the difference between the end-tidal alveolar PO2 and the calculated arterial PO2. The end-tidal PO2 is measured using a rapid gas analyzer, and the arterial PO2 is derived from pulse oximetry after allowing for the effect of the PCO2 on the oxygen affinity of hemoglobin. In the present report we show that the values of end-tidal PO2 and PCO2 are highly reproducible providing a solid foundation for the measurement of the oxygen deficit. Read More

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http://dx.doi.org/10.1152/ajplung.00150.2020DOI Listing
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