640,907 results match your criteria California Encephalitis
Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.
Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More
World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.
Department of Neurological Surgery, University of California, San Francisco, California, USA; Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA. Electronic address: http://skullbaselab.ucsf.edu.
Introduction: Anterior-inferior cerebellar artery (AICA) aneurysms are rare with no optimal consensus on management strategies. When the treatment requires parent artery occlusion post-operative ischemic or neuropathic, complications can occur.
Objective: To evaluate the feasibility of direct revascularization of premeatal AICA using the middle meningeal artery (MMA) as the donor through an anterior petrosectomy (APA) window. Read More
Neuroimage 2018 Dec 3. Epub 2018 Dec 3.
Center for Neuroscience, University of California at Davis, 1544 Newton Court, Davis, CA, 95618, USA; Department of Psychology, University of California at Davis, One Shields Avenue, Davis, CA, 95616, USA.
The efficacy of cognitive training is controversial, and research progress in the field requires an understanding of factors that promote transfer of training gains and their relationship to changes in brain activity. One such factor may be adaptive task difficulty, as adaptivity is predicted to facilitate more efficient processing by creating a prolonged mismatch between the supply of, and the demand upon, neural resources. To test this hypothesis, we measured behavioral and neural plasticity in fMRI sessions before and after 10 sessions of working memory updating (WMU) training, in which the difficulty of practiced tasks either adaptively increased in response to performance or was fixed. Read More
Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.
Department of Psychology, California State University Long Beach, Long Beach, CA 90840, USA. Electronic address:
Alternate day fasting (ADF) is an effective dietary strategy for weight loss in both humans and rats. However, fasting can elicit hyperphagia in rats, particularly upon access to a calorically dense, high-energy (HE) diet. To examine the effects of ADF on HE diet preference, male and female Sprague-Dawley rats were randomly assigned to receive either ad-libitum or alternate day access to both chow and HE food. Read More
Prev Med 2018 Dec 3. Epub 2018 Dec 3.
Department of Community Health Sciences, University of California, Los Angeles, United States of America.
Complex interrelationships between race, sex, obesity and depression have been well-documented. Because of differences in associations between socioeconomic status (SES) and health by race, determining the role of SES may help to further explicate these relationships. The aim of this study was to determine how race and income interact with obesity on depression. Read More
Dev Biol 2018 Dec 3. Epub 2018 Dec 3.
Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA USA.
Regenerative ability is highly variable among the metazoans. While many invertebrate organisms are capable of complete regeneration of entire bodies and organs, whole-organ regeneration is limited to very few species in the vertebrate lineages. Tunicates, which are invertebrate chordates and the closest extant relatives of the vertebrates, show robust regenerative ability. Read More
Dev Biol 2018 Dec 3. Epub 2018 Dec 3.
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address:
MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Read More
Neuron 2018 Dec;100(5):1028-1043
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; The Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Understanding how cortical activity generates sensory perceptions requires a detailed dissection of the function of cortical layers. Despite our relatively extensive knowledge of their anatomy and wiring, we have a limited grasp of what each layer contributes to cortical computation. We need to develop a theory of cortical function that is rooted solidly in each layer's component cell types and fine circuit architecture and produces predictions that can be validated by specific perturbations. Read More
Neuron 2018 Dec;100(5):1025-1027
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:
Human neural network development occurs at stages inaccessible to longitudinal monitoring. By transplanting human neurons to the adult mouse brain, recent studies explore human neural circuit formation in realistic cellular and physiological environments, establishing new models for human neurodevelopmental disorders. Read More
Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.
Case Western Reserve University, Cleveland, Ohio, United States.
Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More
Chembiochem 2018 Dec 6. Epub 2018 Dec 6.
University of California Irvine, Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Biomedical Engineering, 92697, Irvine, UNITED STATES.
Pathogenic bacteria pose a serious public health threat. Rapid and cost effective detection of such bacteria remains a major challenge. Here, we present a DNAzyme-based fluorescent paper sensor for Klebsiella pneumoniae. Read More
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.
Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More
PLoS One 2018 6;13(12):e0208524. Epub 2018 Dec 6.
Department of Psychology, Concordia University, Montréal, Québec, Canada.
The current research explored toddlers' gaze fixation during a scene showing a person expressing sadness after a ball is stolen from her. The relation between the duration of gaze fixation on different parts of the person's sad face (e.g. Read More
PLoS One 2018 6;13(12):e0208406. Epub 2018 Dec 6.
Department of Marine Biology, Texas A&M University at Galveston, Galveston, Texas, United States of America.
Sinking marine oil snow was found to be a major mechanism in the transport of spilled oil from the surface to the deep sea following the Deepwater Horizon (DwH) oil spill. Marine snow formation is primarily facilitated by extracellular polymeric substances (EPS), which are mainly composed of proteins and carbohydrates secreted by microorganisms. While numerous bacteria have been identified to degrade oil, there is a paucity of knowledge on bacteria that produce EPS in response to oil and Corexit exposure in the northern Gulf of Mexico (nGoM). Read More
PLoS Genet 2018 Dec 6;14(12):e1007850. Epub 2018 Dec 6.
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, United States of America.
Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes that contribute to these variations could provide critical insights into the molecular basis of tissue and organismal morphogenesis. Bulldogs, French Bulldogs and Boston Terriers share many morphological and disease-predisposition traits, including brachycephalic skull morphology, widely set eyes and short stature. Read More
PLoS One 2018 6;13(12):e0207392. Epub 2018 Dec 6.
Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Background: Insomnia is one of the main symptoms of sleep disorders. Previous studies have suggested that alcohol intake is associated with several adverse health outcomes. The association between alcohol consumption and insomnia has been addressed in several studies with different results. Read More
PLoS One 2018 6;13(12):e0204110. Epub 2018 Dec 6.
Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, United States of America.
Background/objectives: To analyse the relationship between caregiver burden and severity of patients' cognitive impairment.
Design: Data were drawn from the cross-sectional 2015/2016 Adelphi Real World Dementia Disease-Specific Programme.
Setting: This research was multi-national and studied physicians and their consulting patients with cognitive impairment. Read More
PLoS One 2018 6;13(12):e0206074. Epub 2018 Dec 6.
United States Agency for International Development, Washington, DC, United States of America.
The Tathmini GBV study was a cluster randomized trial to assess the impact of a comprehensive health facility- and community-based program delivered through the HIV/AIDS program platform on reduction in gender-based violence and improved care for survivors. Twelve health facilities and surrounding communities in the Mbeya Region of Tanzania were randomly assigned to intervention or control arms. Population-level effects were measured through two cross-sectional household surveys of women ages 15-49, at baseline (n = 1,299) and at 28 months following program scale-out (n = 1,250). Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006803. Epub 2018 Dec 6.
Zeeman Institute, University of Warwick, Coventry, United Kingdom.
Background: Age patterns in asymptomatic and symptomatic infection with Leishmania donovani, the causative agent of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), are currently poorly understood. Age-stratified serology and infection incidence have been used to assess transmission levels of other diseases, which suggests that they may also be of use for monitoring and targeting control programmes to achieve elimination of VL and should be included in VL transmission dynamic models. We therefore analysed available age-stratified data on both disease incidence and prevalence of immune markers with the aim of collating the currently available data, estimating rates of infection, and informing modelling and future data collection. Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006845. Epub 2018 Dec 6.
MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France.
Background: Diseases caused by Aedes-borne viruses, such as dengue, Zika, chikungunya, and yellow fever, are emerging and reemerging globally. The causes are multifactorial and include global trade, international travel, urbanisation, water storage practices, lack of resources for intervention, and an inadequate evidence base for the public health impact of Aedes control tools. National authorities need comprehensive evidence-based guidance on how and when to implement Aedes control measures tailored to local entomological and epidemiological conditions. Read More
Expert Opin Investig Drugs 2018 Dec 6. Epub 2018 Dec 6.
a Department of Neurology , School of Medicine, University of California Davis , Sacramento , CA , USA.
Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy. Areas covered: The article covers the effects of COX-inhibitors in epilepsy disorders. Read More
FASEB J 2018 Dec 6:fj201801845R. Epub 2018 Dec 6.
Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA; and.
Mesenchymal stem cell (MSC)-mediated immunomodulation affects both innate and adaptive immune systems. These responses to environmental cues, such as pathogen-associated molecular patterns, damage-associated molecular patterns, or proinflammatory cytokines, are crucial for resolution of inflammation, as well as successful tissue healing and regeneration. We observed that intermittent, repeated exposure of MSCs to LPS induced stronger NF-κB activation than singular stimulation. Read More
Chem Res Toxicol 2018 Dec 6. Epub 2018 Dec 6.
Division of Environmental Health Sciences, School of Public Health , University of California , Berkeley , California 94720 , United States.
Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge. Read More
Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.
Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.
Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.
Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More
New Phytol 2018 Dec 6. Epub 2018 Dec 6.
Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK.
High efficiency methods for DNA assembly have enabled routine assembly of synthetic DNAs of increased size and complexity. However, these techniques require customisation, elaborate vector sets or serial manipulations for the different stages of assembly. We have developed Loop assembly based on a recursive approach to DNA fabrication. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a )/CD207 histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive immune systems. Patients with LCH, particularly those with multisystem (MS) involvement, can develop severe hyperinflammation mimicking that observed in HLH. Read More
J Am Geriatr Soc 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Division of Geriatrics, University of California, San Francisco, San Francisco, California.
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.
Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
BC Cancer-Vancouver Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Abiraterone acetate plus prednisone (AA+P), when added to androgen deprivation therapy (ADT), demonstrated significant improvements in overall survival and disease progression over dual placebos added to ADT in the LATITUDE clinical trial (NCT01715285). The objective of this study was to assess event-driven medical resource utilization (MRU) of ADT plus AA+P (ADT+AA+P) versus ADT plus dual placebos (ADT+placebos) in LATITUDE.
Methods: Event-driven MRU data from LATITUDE while patients were on treatment were used for analyses. Read More
Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.
Centre for Marine Bio-Innovation and School of Biological, Earth and Environmental Sciences, The University of New South Wales, Sydney, 2052, Australia.
Syst Biol 2018 Dec 6. Epub 2018 Dec 6.
Museum of Natural Science, Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.
Resolving patterns of ancient and rapid diversifications is one of the most challenging tasks in evolutionary biology. These difficulties arise from confusing phylogenetic signals that are associated with the interplay of incomplete lineage sorting and homoplasy. Phylogenomic analyses of hundreds, or even thousands, of loci offer the potential to resolve such contentious relationships. Read More
Arch Clin Neuropsychol 2018 Dec 6. Epub 2018 Dec 6.
VA San Diego Healthcare System (VASDHS); San Diego, CA, USA.
Objective: We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI).
Method: Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). Read More
JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Center for Health Policy at Meharry Medical College, Nashville, Tennessee.
Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.
Veterans Affairs San Diego Healthcare System and University of California San Diego, San Diego, California.
JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Weill Cornell Medical College, New York, New York.
Importance: Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity is associated with increased risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.
Objective: To investigate the association between body fat and breast cancer risk in women with normal BMI. Read More
JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Francis I. Proctor Foundation, University of California, San Francisco.
Importance: Uveitis involves dysregulation of the ocular immune system. Stress has been shown to affect immune function, but it is unclear whether there is an association between stress and uveitis.
Objective: To determine whether having uveitis is associated with psychological stress. Read More
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry, New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York.
Importance: Age-related hearing loss is highly prevalent and has recently been associated with numerous morbid conditions of aging. Late-life depression is also prevalent and can be resistant to available treatments. Preliminary studies examining the association between hearing loss and late-life depression have been limited by subjective hearing measures, small sample sizes, and primarily white populations. Read More
JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Importance: The 2013/2014 American Society of Clinical Oncology and College of American Pathologists (ASCO-CAP) guidelines for HER2 testing by fluorescence in situ hybridization (FISH) designated an "equivocal" category (average HER2 copies per tumor cell ≥4-6 with HER2/CEP17 ratio <2.0) to be resolved as negative or positive by assessments with alternative control probes. Approximately 4% to 12% of all invasive breast cancers are characterized as HER2-equivocal based on FISH. Read More
Environ Entomol 2018 Dec 6. Epub 2018 Dec 6.
Department of Environmental Science, Policy and Management, University of California Berkeley, 130 Mulford Hall, Berkeley, CA 94720-3114.
A phenology model of the walnut husk fly, Rhagoletis completa Cresson, was developed to more accurately predict the timing of the flight period and optimize management decisions. A data set of 153 orchard years in which adults were trapped throughout the season was used for the development and validation of this model. Data from California Irrigation Management Information System (CIMIS) weather stations were used to match orchard-year datasets with historical climatic data on degree-day (DD) accumulation, winter chill, and winter rainfall. Read More
Cardiovasc Res 2018 Dec 5. Epub 2018 Dec 5.
La Jolla Institute of Immunology, La Jolla, California, USA.
Aims: To test whether human immunodeficiency virus (HIV) infection and subclinical cardiovascular disease (sCVD) are associated with expression of CXCR4 and other surface markers on classical, intermediate, and non-classical monocytes in women.
Methods And Results: sCVD was defined as presence of atherosclerotic lesions in the carotid artery in 92 participants of the Women's Interagency HIV Study (WIHS). Participants were stratified into 4 sets (n = 23 each) by HIV and sCVD status (HIV-/sCVD-, HIV-/sCVD+, HIV+/sCVD-, HIV+/sCVD+) matched by age, race/ethnicity, and smoking status. Read More
JAMA 2018 Dec 6. Epub 2018 Dec 6.
Harvard Business School, Boston, Massachusetts.
Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.
Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden. and Department of Chemistry, Ångström Laboratory, Uppsala University, Box 538 751 21, Uppsala, Sweden and Centre of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry Aleea Grigore Ghica-Voda, 41A, 700487 Iasi, Romania.
We have studied the shear flow of the smectic A phase of three coarse grained liquid crystal model systems, namely two versions of the Gay-Berne fluid and the soft sphere string-fluid. At low shear rates, the orientation where the smectic layers are parallel to the shear plane and the orientation parallel to the vorticity plane are both stable in all the systems. In one of the Gay-Berne fluids, there is a transition from the orientation parallel to the shear plane to the orientation parallel to the vorticity plane. Read More
Nat Biotechnol 2018 Dec;36(12):1217-1219
Career and Postdoctoral Services Office, The Scripps Research Institute, La Jolla, California, USA.
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Department of Pathology, Stanford University School of Medicine, Stanford, CA.
The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More
Acad Med 2018 Dec 4. Epub 2018 Dec 4.
J.D. Gonzalo is associate professor of medicine and public health sciences and associate dean for health systems education, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0003-1253-2963. A. Chang is professor of medicine, Gold-Headed Cane Endowed Education Chair in Internal Medicine, University of California, San Francisco, School of Medicine, San Francisco, California. D. R. Wolpaw is professor of medicine and humanities, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0002-7567-2034.
To address gaps in U.S. health care outcomes, medical education is evolving to incorporate new competencies, as well as to align with care delivery transformation and prepare systems-ready providers. Read More