659,401 results match your criteria California Cooperative Oceanic Fisheries Investigations Reports[Journal]


Cardiovascular Benefits of a Diet Enriched in Fruits and Vegetables.

Am J Nephrol 2019 Apr 17;49(6):435-437. Epub 2019 Apr 17.

Distinguished Scientist-in-Residence, Department of Health Studies, College of Arts and Sciences, American University, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1159/000500044DOI Listing

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia.

Dev Neurosci 2019 Apr 17:1-14. Epub 2019 Apr 17.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Read More

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http://dx.doi.org/10.1159/000496467DOI Listing

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1.

Cardiorenal Med 2019 Apr 17;9(4):212-221. Epub 2019 Apr 17.

Kidney Disease Branch, NIDDK, Bethesda, Maryland, USA,

Background: Observational studies show that African American (AA) dialysis patients have longer survival than European Americans. We hypothesized that apolipoprotein L1 (APOL1) genetic variation, associated with nephropathy in AAs, contributes to the survival advantage in AA dialysis patients.

Methods: We examined the association between race and mortality among 37,097 adult dialysis patients, including 54% AAs and 46% European Americans from a large dialysis organization (entry period from July 2001 to June 2006, follow-up through June 2007), within each cause of end-stage renal disease (ESRD) category associated with APOL1 renal risk variants using Cox proportional hazard models. Read More

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https://www.karger.com/Article/FullText/496472
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http://dx.doi.org/10.1159/000496472DOI Listing
April 2019
1 Read

Tunable spin-state bistability in a spin crossover molecular complex.

J Phys Condens Matter 2019 Apr 17. Epub 2019 Apr 17.

Department of Physics and Astronomy and Center for Materials Research and Analysis, University of Nebraska- Lincoln, Jorgensen Hall, 855 North 16th Str., NE 68588-0299, Lincoln, 68588-0299, UNITED STATES.

The spin crossover (SCO) transitions at both the surface and over the entire volume of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] polycrystalline films on Al2O3 substrates have been studied, where pz = pyrazol-1-yl and bipy = 2,2'-bipyridine. For [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] films of hundreds of nm thick, magnetometry and x-ray absorption spectroscopy measurements show thermal hysteresis in the SCO transition with temperature, although the transition in bulk [Fe{H2B(pz)2}2(bipy)] occurs in a non-hysteretic fashion at 157 K. While the size of the crystallites in those films are similar, the hysteresis becomes more prominent in thinner films, indicating a significant effect of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)]/Al<sub>2</sub>O<sub>3</sub> interface. Read More

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http://iopscience.iop.org/article/10.1088/1361-648X/ab1a7d
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http://dx.doi.org/10.1088/1361-648X/ab1a7dDOI Listing
April 2019
1 Read
2.346 Impact Factor

Determinants of structural segregation and patterning in the human cortex.

Neuroimage 2019 Apr 14. Epub 2019 Apr 14.

Department of Anatomy & Neurobiology, University of California, Irvine, USA.

This study aimed at uncovering mechanisms that govern the spatio-temporal patterning of the human cortex and its structural variability, and drawing links between fetal brain development and variability in adult brains. A data-driven analytic approach based on structural MR images revealed the following findings: (1) The cortical surface can be subdivided into 13 independent regions ("communities") based on macroscopic features. (2) Thirty centers of low inter-subject variability were found in major sulci on the cortical surface. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193031
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http://dx.doi.org/10.1016/j.neuroimage.2019.04.031DOI Listing
April 2019
1 Read

Anesthesia for pediatric ophthalmologic surgery.

J AAPOS 2019 Apr 14. Epub 2019 Apr 14.

Department of Anesthesiology, California Pacific Medical Center, Sutter Hospitals, Northern California Anesthesia Physicians, San Francisco, California.

This review presents updated recommendations, based on existing clinical research, for anesthetic management of strabismus surgery in children. In children, unlike adults, eye surgery nearly always requires general anesthesia, even for brief procedures. Recommendations for preoperative anxiolysis, fasting guidelines, and management of upper respiratory infections are discussed. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.10.017DOI Listing

The Cytokines of Asthma.

Immunity 2019 Apr;50(4):975-991

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA.

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.018DOI Listing

Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment.

Cell Rep 2019 Apr;27(3):658-665.e4

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Program in Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

CaMKIIα is a central mediator of bidirectional synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). To study how CaMKIIα movement during plasticity is affected by soluble amyloid-β peptide oligomers (Aβ), we used FingR intrabodies to simultaneously image endogenous CaMKIIα and markers for excitatory versus inhibitory synapses in live neurons. Aβ blocks LTP-stimulus-induced CaMKIIα accumulation at excitatory synapses. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.041DOI Listing

Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy. Reply.

N Engl J Med 2019 04;380(16)

University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1056/NEJMc1805100DOI Listing

Catheter Ablation of Ventricular Arrhythmias.

N Engl J Med 2019 04;380(16):1555-1564

From the University of California, Los Angeles (UCLA), Cardiac Arrhythmia Center and Electrophysiology Programs, David Geffen School of Medicine at UCLA, Los Angeles.

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http://dx.doi.org/10.1056/NEJMra1615244DOI Listing

Accuracy of Valuations of Surgical Procedures in the Medicare Fee Schedule.

N Engl J Med 2019 04;380(16):1546-1554

From the Center for Health Policy-Center for Primary Care and Outcomes Research, Stanford University School of Medicine (D.C.C., D.M.S.), and Stanford Law School (D.M.S.), Stanford, the Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto (D.C.C.), and the Department of Economics, University of California Los Angeles, Los Angeles (J.H.) - all in California.

Background: The Relative Value Scale Update Committee (RUC) of the American Medical Association plays a central role in determining physician reimbursement. The RUC's role and performance have been criticized but subjected to little empirical evaluation.

Methods: We analyzed the accuracy of valuations of 293 common surgical procedures from 2005 through 2015. Read More

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http://dx.doi.org/10.1056/NEJMsa1807379DOI Listing

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 04;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
1 Read

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
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Responding to Evolving Abortion Regulations - The Critical Role of Primary Care.

N Engl J Med 2019 Apr 17. Epub 2019 Apr 17.

From the Division of General Internal Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, and the University of California, San Francisco - both in San Francisco.

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http://dx.doi.org/10.1056/NEJMp1903572DOI Listing

A placebo-controlled pilot study of a wearable morning bright light treatment for probable PTSD.

Depress Anxiety 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois.

Background: Evidence-based treatments for post-traumatic stress disorder (PTSD) have poor uptake and remission rates, suggesting that alternative treatments are needed. Morning bright light may be an effective treatment for PTSD given its established effects on mood and sleep, however, there are no published trials.

Methods: We conducted a placebo-controlled pilot trial of a wearable light device, the Re-timer®, for individuals with probable PTSD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22897
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http://dx.doi.org/10.1002/da.22897DOI Listing
April 2019
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Scalable biosynthesis of the seaweed neurochemical kainic acid.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

University of California at San Diego, Scripps Institution of Oceanography, 9500 Gilman Dr., 92093-0204, La Jolla, UNITED STATES.

Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors, including the kainate receptor, in the central nervous system. Worldwide shortages of this seaweed natural product in 2000 prompted numerous chemical syntheses that now number in excess of 70, including scalable preparations with as few as six-steps. Herein we report the discovery and characterization of the concise two-enzyme biosynthetic pathway to kainic acid from L-glutamic acid and dimethylallyl pyrophosphate in red macroalgae and show that the biosynthetic genes are co-clustered in genomes of Digenea simplex and the edible Palmaria palmata. Read More

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http://dx.doi.org/10.1002/anie.201902910DOI Listing

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1571-1580

Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, United States.

Purpose: To understand the role and further dissect pathways downstream of tissue plasminogen activator (tPA) and the fibrinolytic pathway in modulating outflow facility.

Methods: Outflow facility of tissue plasminogen activator (Plat) knockout (KO) mice was determined and compared to that of wild-type (WT) littermates. Gene expression of urokinase plasminogen activator (Plau), plasminogen activator inhibitor (Pai-1), plasminogen (Plg), and matrix metalloproteinases (Mmp-2, -9, and -13) was measured in angle tissues. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-25698DOI Listing
April 2019
1 Read
3.404 Impact Factor

Performance of Matching Methods to Unmatched Ordinary Least Squares Regression Under Constant Effects.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Center for Population Health Sciences, Department of Medicine, Stanford University, Palo Alto, California.

Matching methods are assumed to reduce the likelihood of a biased inference compared to ordinary least squares regression. Using simulations, we compare inferences from propensity score matching, coarsened exact matching, and un-matched covariate-adjusted ordinary least squares regression (OLS) to identify which methods, in which scenarios, produced unbiased inferences at the expected type I error rate of 5%. We simulated multiple datasets and systematically varied common support, discontinuities in the exposure and / or outcome, exposure prevalence, and analytic model misspecification. Read More

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http://dx.doi.org/10.1093/aje/kwz093DOI Listing

Commentary on: Sub-Scarpa's Lipectomy in Abdominoplasty: An Analysis of Risks and Rewards in 723 Consecutive Patients.

Aesthet Surg J 2019 Apr 17. Epub 2019 Apr 17.

Dr Rosenfield is a Professor of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco (UCSF), San Francisco, CA; and an Adjunct Clinical Professor, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA.

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http://dx.doi.org/10.1093/asj/sjz085DOI Listing

Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing

Differences in Tsimane children's growth outcomes and associated determinants as estimated by WHO standards vs. within-population references.

PLoS One 2019 17;14(4):e0214965. Epub 2019 Apr 17.

Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, United States of America.

Anthropometric measures are commonly converted to age stratified z-scores to examine variation in growth outcomes in mixed-age and sex samples. For many study populations, z-scores will differ if calculated from World Health Organization (WHO) growth standards or within-population references. The specific growth reference used may influence statistical estimates of growth outcomes and their determinants, with implications for biological inference. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214965PLOS

Effect of modulating braille dot height on reading regressions.

PLoS One 2019 17;14(4):e0214799. Epub 2019 Apr 17.

The Smith-Kettlewell Eye Research Institute, San Francisco, California, United States of America.

It is well known that people who read print or braille sometimes make eye or finger movements against the reading direction. The way these regressions are elicited has been studied in detail by manipulating linguistic aspects of the reading material. Actually, it has been shown that reducing the physical intensity or clarity of the visual input signal can also lead to increased regressions during reading. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214799PLOS

Putative parapoxvirus-associated foot disease in the endangered huemul deer (Hippocamelus bisulcus) in Bernardo O'Higgins National Park, Chile.

PLoS One 2019 17;14(4):e0213667. Epub 2019 Apr 17.

One Health Institute, School of Veterinary Medicine, University of California, Davis, CA, United States of America.

The huemul (Hippocamelus bisulcus) is an endangered cervid endemic to southern Argentina and Chile. Here we report foot lesions in 24 huemul from Bernardo O'Higgins National Park, Chile, between 2005 and 2010. Affected deer displayed variably severe clinical signs, including lameness and soft tissue swelling of the limbs proximal to the hoof or in the interdigital space, ulceration of the swollen tissues, and some developed severe proliferative tissue changes that caused various types of abnormal wear, entrapment, and/or displacement of the hooves and/or dewclaws. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213667PLOS

Pharmacokinetics of Cefazolin and Vancomycin in Infants Undergoing Open-Heart Surgery With Cardiopulmonary Bypass.

Anesth Analg 2019 May;128(5):935-943

Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pediatric Cardiac Anesthesia, Stanford University School of Medicine, Stanford, California.

Background: Gram-positive bacteria account for nearly three-quarters of all surgical site infections. Antibiotic prophylaxis against these bacteria with cephalosporins or, in select circumstances, with vancomycin is considered standard of care for prevention of surgical site infections. There is little evidence to describe the optimal dosing regimen for surgical site infection prophylaxis in infants undergoing cardiac surgery, and a great deal of institutional variability exists in dosing prophylactic antibiotics. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003876DOI Listing
May 2019
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LIMPRINT: Elucidating the Global Problem of Lymphedema.

Lymphat Res Biol 2019 Apr;17(2):119-120

Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1089/lrb.2019.29062.srDOI Listing

Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia.

J Clin Oncol 2019 Apr 17:JCO1801460. Epub 2019 Apr 17.

18 Ulm University, Ulm, Germany.

Purpose: A randomized, double-blind, phase III study of idelalisib (IDELA) plus rituximab versus placebo plus rituximab in patients with relapsed chronic lymphocytic leukemia (CLL) was terminated early because of superior efficacy of the IDELA-plus-rituximab (IDELA/R) arm. Patients in either arm could then enroll in an extension study to receive IDELA monotherapy. Here, we report the long-term efficacy and safety data for IDELA-treated patients across the primary and extension studies. Read More

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http://dx.doi.org/10.1200/JCO.18.01460DOI Listing

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.

J Clin Oncol 2019 Apr 17:JCO1801575. Epub 2019 Apr 17.

17 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The primary objective was to determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival (RFS) compared with pelvic radiation therapy (RT) in high-intermediate and high-risk early-stage endometrial carcinoma.

Patients And Methods: A randomized phase III trial was performed in eligible patients with endometrial cancer. Eligible patients had International Federation of Gynecology and Obstetrics (2009) stage I endometrioid histology with Gynecologic Oncology Group protocol 33-based high-intermediate-risk criteria, stage II disease, or stage I to II serous or clear cell tumors. Read More

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http://dx.doi.org/10.1200/JCO.18.01575DOI Listing

Identifying Developmental Language Disorder in Vietnamese Children.

J Speech Lang Hear Res 2019 Apr 17:1-16. Epub 2019 Apr 17.

San Diego State University, CA.

Purpose Developmental language disorder (DLD), defined by low language performance despite otherwise normal development, can negatively impact children's social and academic outcomes. This study is the 1st to examine DLD in Vietnamese. To lay the foundation, we identified cases of DLD in Vietnam and explored language-specific characteristics of the disorder. Read More

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http://dx.doi.org/10.1044/2019_JSLHR-L-18-0305DOI Listing

Psychometric Functions of Vowel Detection and Identification in Long-Term Speech-Shaped Noise.

J Speech Lang Hear Res 2019 Apr 17:1-13. Epub 2019 Apr 17.

Department of Communication Sciences and Disorders, California State University, Northridge.

Purpose The goal of this study was to investigate vowel detection and identification in noise and provide baseline data regarding how vowel perception changed with signal-to-noise ratios. Psychometric functions of vowel detection and identification for 12 American English isolated vowels in long-term speech-shaped noise were examined for young listeners with normal hearing in this study. Method Vowel detection was measured at sensation levels from -10 to +5 dB (re: thresholds of vowel detection from the study of Liu and Eddins, 2008a ) with a 4-interval forced-choice procedure. Read More

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http://pubs.asha.org/doi/10.1044/2018_JSLHR-H-18-0320
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http://dx.doi.org/10.1044/2018_JSLHR-H-18-0320DOI Listing
April 2019
1 Read

A bipartite begomovirus infecting (family ) in the Dominican Republic represents a distinct phylogenetic lineage and has a high degree of host specificity.

Phytopathology 2019 Apr 17. Epub 2019 Apr 17.

University of California, Davis, Department of Plant Pathology , 1 Shields Ave , Davis, California, United States , 95616 ;

plants in and around agricultural fields in the Azua Valley of the southeastern Dominican Republic often show striking golden mosaic symptoms. Leaf samples from plants showing these symptoms were collected in 2012 and 2013, and PCR tests with degenerate primers revealed begomovirus DNA-A and DNA-B components. The complete sequences of the DNA-A and DNA-B components of four isolates show high degree of sequence identity (>96%), and a genome organization typical of New World (NW) bipartite begomoviruses. Read More

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http://dx.doi.org/10.1094/PHYTO-02-19-0061-RDOI Listing

Aerial Concentrations of Pathogens Causing Early Blight and Brown Spot within Susceptible Potato Fields.

Phytopathology 2019 Apr 17. Epub 2019 Apr 17.

University of Wisconsin, Plant Pathology , 1630 Linden Drive , Room 689 , Madison, Wisconsin, United States , 53706 ;

Early blight caused by and brown spot caused by are two common foliar diseases of potato, with early blight typically predominating in incidence and severity. Renewed interest in these two diseases has arisen due to notable difference in fungicide resistance profiles of the pathogens and inconsistent outcomes of disease management strategies. The pathogens share similar disease cycles, but they differ in shape and size of conidia. Read More

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http://dx.doi.org/10.1094/PHYTO-10-18-0381-RDOI Listing

Role of KASH domain lengths in the regulation of LINC complexes.

Mol Biol Cell 2019 Apr 17:mbcE19020079. Epub 2019 Apr 17.

Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, United States.

The LINC complex is formed by the conserved interactions between SUN and KASH domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. For example, In , SUN protein UNC-84 binds to two KASH proteins UNC-83 and ANC-1 to mediate nuclear migration and anchorage, respectively. Read More

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https://www.molbiolcell.org/doi/10.1091/mbc.E19-02-0079
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http://dx.doi.org/10.1091/mbc.E19-02-0079DOI Listing
April 2019
1 Read

Digest.

J Sport Exerc Psychol 2019 Apr 17:1-5. Epub 2019 Apr 17.

10 California State University-Fullerton.

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http://dx.doi.org/10.1123/jsep.2019-0031DOI Listing

Growth of and Other Foodborne Pathogens on Inoculated Inshell Pistachios during Simulated Delays between Hulling and Drying.

J Food Prot 2019 Apr 17:815-825. Epub 2019 Apr 17.

Department of Food Science and Technology, University of California, One Shields Avenue, Davis, California 95616, USA (ORCID: https://orcid.org/0000-0002-1911-752X [L.J.H.]).

During harvest, pistachios are hulled, separated in water into floater and sinker streams (in large part on the basis of nut density), and then dried before storage. Higher prevalence and levels of were previously observed in floater pistachios, but contributing factors are unclear. To examine the behavior of pathogens on hulled pistachios during simulated drying delays, floater and sinker pistachios collected from commercial processors were inoculated at 1 or 3 log CFU/g with cocktails of and in some cases O157:H7 or and incubated for up to 30 h at 37°C and 90% relative humidity. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-450DOI Listing

Gene Deletion of the Na-Glucose Cotransporter SGLT1Ameliorates Kidney Recovery in a Murine Model of Acute Kidney InjuryInduced by Ischemia-Reperfusion.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Departments of Medicine and Pharmacology, University of California San Diego and the Veterans Administration San Diego Healthcare System, United States.

The renal Na-glucose cotransporter SGLT1 mediates glucose reabsorption in the late proximal tubule, a hypoxia-sensitive tubular segment that enters the outer medulla. Gene-deletion in mice () was used to determine the role of the cotransporter in acute kidney injury (AKI) induced by ischemia-reperfusion (IR), including the initial injury and the subsequent recovery phase. On day 1 and 16 after IR, absolute and fractional urinary glucose excretion remained greater in versus wild-type littermates (WT), consistent with a sustained contribution of SGLT1 to tubular glucose reabsorption in WT. Read More

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http://dx.doi.org/10.1152/ajprenal.00111.2019DOI Listing

Differential YAP nuclear signaling in healthy and dystrophic skeletal muscle.

Am J Physiol Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Departments of Orthopaedics and Physiology, University of Maryland School of Medicine, United States.

Mechanical forces regulate muscle development, hypertrophy, and homeostasis. Force-transmitting structures allow mechanotransduction at the sarcolemma, cytoskeleton, and nuclear envelope. There is growing evidence that YAP (Yes-associated protein) serves as a nuclear relay of mechanical signals and can induce a range of downstream signaling cascades. Read More

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http://dx.doi.org/10.1152/ajpcell.00432.2018DOI Listing

Outcomes of Revision Anterior Cruciate Ligament Surgery in Adolescents.

Am J Sports Med 2019 Apr 17:363546519837173. Epub 2019 Apr 17.

Department of Orthopedic Surgery, University of California, San Diego, California, USA.

Background: Although primary anterior cruciate ligament (ACL) reconstructions have been well studied in children and adolescents, the literature lacks information about revision ACL reconstructions in this population.

Purpose: This study aims to analyze the outcomes of revision ACL surgeries in the pediatric population.

Study Design: Case series; Level of evidence, 4. Read More

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http://dx.doi.org/10.1177/0363546519837173DOI Listing
April 2019
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Quantitative MRI Musculoskeletal Techniques: An Update.

AJR Am J Roentgenol 2019 Apr 17:1-10. Epub 2019 Apr 17.

1 Department of Radiology, University of California, San Diego Medical Center, San Diego, CA.

For many years, MRI of the musculoskeletal system has relied mostly on conventional sequences with qualitative analysis. More recently, using quantitative MRI applications to complement qualitative imaging has gained increasing interest in the MRI community, providing more detailed physiologic or anatomic information. In this article, we review the current state of quantitative MRI, technical and software advances, and the most relevant clinical and research musculoskeletal applications of quantitative MRI. Read More

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http://dx.doi.org/10.2214/AJR.19.21143DOI Listing

Partial Transphyseal Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Radiographic Outcomes.

Am J Sports Med 2019 Apr 17:363546519836423. Epub 2019 Apr 17.

Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.

Background: With a steadily increasing rate of anterior cruciate ligament (ACL) injury and reconstruction in the pediatric population, disagreement remains regarding the optimal reconstruction technique for patients with ACL injury and ≥2 years of growth remaining.

Purpose: This study aims to quantify the incidence of linear and angular growth disturbance of adolescents undergoing partial transphyseal ACL reconstruction (ACLR) while assessing graft failure rates, reoperation rates, and functional outcomes in the population.

Study Design: Case series; Level of evidence, 4. Read More

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http://dx.doi.org/10.1177/0363546519836423DOI Listing

Synthesis of C14-Desmethylene Corialactone D and Discovery of Inhibitors of Nerve Growth Factor Mediated Neurite Outgrowth.

Org Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry , Dartmouth College , Burke Laboratory, Hanover , New Hampshire 03755 , United States.

An asymmetric synthesis of C14-desmethylene corialactone D is described on the basis of strategic application of a metallacycle-mediated annulative cross-coupling reaction, a Still [2,3]-Wittig rearrangement, and Morken's hydroxyl-directed diboration reaction. While representing a convenient approach to access novel compositions of matter inspired by the sesquiterpenoid natural product class (including classic natural product synthesis targets including the picrotaxanes and dendrobine), these studies have led to the discovery of natural product-inspired agents that inhibit nerve growth factor (NGF)-mediated neurite outgrowth in PC-12 cells. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00921DOI Listing

On-Board Sensor-Based NO Emissions from Heavy-Duty Diesel Vehicles.

Environ Sci Technol 2019 Apr 17. Epub 2019 Apr 17.

Real-world nitrogen oxides (NO) emissions were estimated using on-board sensor readings from 72 heavy-duty diesel vehicles (HDDVs) equipped with Selective Catalytic Reduction (SCR) system in California. The results showed that there were large differences between in-use and certification NO emissions, with 12 HDDVs emitted more than three times the standard during hot-running and idling operations in the real world. The overall NO conversion efficiencies of the SCR system on many vehicles were well below the 90% threshold that is expected for an efficient SCR system, even when the SCR system was above the optimum operating temperature threshold of 250°C. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b07048
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http://dx.doi.org/10.1021/acs.est.8b07048DOI Listing
April 2019
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Genetic risk, body mass index, and weight control behaviors: Unlocking the triad.

Int J Eat Disord 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, University of California, San Francisco, San Francisco, California.

Background: The relationship between genetic risk for body mass index (BMI) and weight control behaviors remains unknown. The objectives of this study were to determine the association between genetic risk for BMI and weight control behaviors in young adults, and to examine actual measured BMI as a potential mediator variable.

Method: We analyzed data from three data collection waves of the National Longitudinal Study of Adolescent to Adult Health. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eat.23083
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http://dx.doi.org/10.1002/eat.23083DOI Listing
April 2019
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Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.

Ann N Y Acad Sci 2019 Apr 17. Epub 2019 Apr 17.

Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.

Maternal anemia is a well-recognized global health problem; however, there remain questions on specific hemoglobin (Hb) thresholds that predict health risk or protection for mother and child. We conducted a systematic review and meta-analysis to examine the associations of maternal Hb concentrations with a range of maternal and infant health outcomes, accounting for the timing of measurement (preconception, and first, second, and third trimesters), etiology of anemia, and cutoff category. The systematic review included 272 studies and the meta-analysis included 95 studies. Read More

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http://dx.doi.org/10.1111/nyas.14093DOI Listing

The genetic relationship between alcohol consumption and aspects of problem drinking in an ascertained sample.

Alcohol Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Background: Genome-wide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples.

Methods: In 6,731 European-Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol-related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the self-rating of effects of ethanol questionnaire (SRE-T), DSM-IV alcohol dependence (DSM4AD), DSM-5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an SNP (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.14064
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http://dx.doi.org/10.1111/acer.14064DOI Listing
April 2019
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H-index and Academic Medicine.

Am J Clin Pathol 2019 Apr 17. Epub 2019 Apr 17.

Biomedical Branch Library University of British Columbia Vancouver, Canada.

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http://dx.doi.org/10.1093/ajcp/aqz037DOI Listing

Pathogenic effects of agrin V1727F mutation are isoform-specific and decrease its expression and affinity for HSPGs and LRP4.

Hum Mol Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA.

Agrin is a large extracellular matrix protein whose isoforms differ in their tissue distribution and function. Motoneuron-derived y+z+ agrin regulates the formation of the neuromuscular junction (NMJ), while y-z- agrin is widely expressed and has diverse functions. Previously we identified a missense mutation (V1727F) in the second laminin-G domain (LG2) of agrin that causes severe congenital myasthenic syndrome. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz081DOI Listing
April 2019
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Impact of abstinence and of reducing illicit drug use without abstinence on HIV viral load.

Clin Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, WA.

Background: Substance use is common among people living with HIV (PLWH) and a barrier to achieving viral suppression.

Objective: Among PLWH who report illicit drug use, we evaluated associations between HIV viral load (VL) and reduced use of illicit opioids, methamphetamine/crystal, cocaine/crack, and marijuana, regardless of whether or not abstinence was achieved.

Design: Longitudinal cohort studySetting/participantsPLWH in clinical care at 8 HIV clinics or 5 clinical studies. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz299DOI Listing
April 2019
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Graph-Based data integration from bioactive peptide databases of pharmaceutical interest: towards an organized collection enabling visual network analysis.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

Departamento de Ciencias de la Computación, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, Mexico.

Motivation: Bioactive peptides have gained great attention in the academy and pharmaceutical industry since they play an important role in human health. However, the increasing number of bioactive peptide databases is causing the problem of data redundancy and duplicated efforts. Even worse is the fact that the available data is non-standardized and often dirty with data entry errors. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz260DOI Listing

Variance of Basal Cell Carcinoma Subtype Reporting by Practice Setting.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamadermatol.2019.0066DOI Listing

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1538-1546

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States.

Purpose: Recent evidence suggests that retinal photoreceptor cells have an important role in the pathogenesis of retinal microvascular lesions in diabetes. We investigated the role of rod cell phototransduction on the pathogenesis of early diabetic retinopathy (DR) using Gnat1-/- mice (which causes permanent inhibition of phototransduction in rod cells without degeneration).

Methods: Retinal thickness, oxidative stress, expression of inflammatory proteins, electroretinograms (ERG) and optokinetic responses, and capillary permeability and degeneration were evaluated at up to 8 months of diabetes. Read More

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http://dx.doi.org/10.1167/iovs.18-26433DOI Listing
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