2,748 results match your criteria Calcium Pyrophosphate Deposition Disease


Dinosaur senescence: a hadrosauroid with age-related diseases brings a new perspective of "old" dinosaurs.

Sci Rep 2021 Jun 11;11(1):11947. Epub 2021 Jun 11.

Institute of Earth Sciences, Faculty of Natural Sciences, University of Silesia, Będzińska 60, 41-200, Sosnowiec, Poland.

Senile vertebrates are extremely rare in the fossil record, making their recognition difficult. Here we present the largest known representative of the Late Cretaceous hadrosauriform Gobihadros mongoliensis showing features of cessation of growth indicating attainment of the terminal size. Moreover, this is the first non-avian dinosaur with an age-related pathology recognized as primary calcium pyrophosphate deposition disease indicating its advanced age. Read More

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COVID-19 in patients with gout on colchicine.

Rheumatol Int 2021 Jun 5. Epub 2021 Jun 5.

Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece.

Current data demonstrated that severe cases of coronavirus-disease-19 (COVID-19) require treatment with antiviral therapy, dexamethasone, supportive care, as well as some anti-rheumatic drugs, among them, cytokine inhibitors and colchicine. Colchicine is an anti-inflammatory drug that is being used in rheumatology for many years to treat mostly gout, calcium pyrophosphate deposition disease, and Familial Mediterranean Fever. Here, we present for the first time, two patients suffering from gout being treated with colchicine, who were affected from severe acute respiratory coronavirus-2 (SARS-CoV-2) syndrome. Read More

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The role of Interleukin-1 receptor antagonist as a treatment option in calcium pyrophosphate crystal deposition disease.

Mol Biol Rep 2021 Jun 1. Epub 2021 Jun 1.

Rheumatology Clinic "Mario Carrozzo", Department of Medical and Surgical Sciences, University of Foggia, "Policlinico Riuniti" University Hospital, Viale Pinto, 1, 71121, Foggia, Italy.

Calcium Pyrophosphate Crystal Deposition (CPPD) disease is characterized by the deposition of calcium pyrophosphate crystals in the cartilage. In most cases, it can manifest as a subclinical condition named chondrocalcinosis, often revealed by joint x-ray examination. In other cases, deposition can cause flares of arthritis, known as acute CPP crystal arthritis. Read More

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How to Differentiate Gout, Calcium Pyrophosphate Deposition Disease, and Osteoarthritis Using Just Four Clinical Parameters.

Diagnostics (Basel) 2021 May 21;11(6). Epub 2021 May 21.

Clinic of Internal Medicine III, Hematology, Oncology, Rheumatology and Clinical Immunology, University Hospital of Bonn, 53127 Bonn, Germany.

Clinical differentiation between gout, osteoarthritis (OA), and calcium pyrophosphate deposition disease (CPPD) remains a hurdle in daily practice without imaging or arthrocentesis. We performed a retrospective analysis of consecutive patients with gout, CPPD, and OA at a tertiary rheumatology center. A total of 277 patients were enrolled, with 164 suffering from gout, 76 from CPPD, and 37 from OA. Read More

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Calcium pyrophosphate deposition disease involving "the largest" Bursa in the human body.

J Nephrol 2021 May 31. Epub 2021 May 31.

Department of Nephrology and Rheumatology, Chubu Rosai Hospital, 1-10-6 Koumei, Minato-ku, Nagoya, Japan.

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Ultra-high resolution 3D MRI for chondrocalcinosis detection in the knee-a prospective diagnostic accuracy study comparing 7-tesla and 3-tesla MRI with CT.

Eur Radiol 2021 May 28. Epub 2021 May 28.

Department of Radiology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Objectives: To test the diagnostic accuracy of a 3D dual-echo steady-state (DESS) sequence at 7-T MRI regarding the detection of chondral calcific deposits of the knee in comparison to 3-T MRI, using CT as cross-sectional imaging reference standard.

Methods: CT and 7-T MRI (DESS) of knee joints in 42 patients with radiographically known chondrocalcinosis (13 of 42 bilateral) were prospectively acquired for all included patients (n = 55 knee joints). Additionally, 3-T MRI (DESS) was performed for 20 of these 55 knee joints. Read More

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Answer to Cipolletta et al. "Treatment of acute CPP crystal arthritis: what are we missing?". Joint Bone Spine 2021;88:105217.

Joint Bone Spine 2021 May 21:105223. Epub 2021 May 21.

Rheumatology Department, Lausanne University Hospital, 1005 Lausanne, Switzerland.

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Unusual calcium pyrophosphate deposition disease.

Rheumatology (Oxford) 2021 May 19. Epub 2021 May 19.

internal medicine department, Aix Marseillle université, APHM, CHU La Timone, Marseille, 13 005, France.

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Treatment of acute CPP crystal arthritis: What are we missing? Comment on: "Anakinra compared to prednisone in the treatment of acute CPPD crystal arthritis: A randomized controlled double-blinded pilot study" by Dumusc A. et al. Joint Bone Spine. 2020;88:105088.

Joint Bone Spine 2021 May 14;88(5):105217. Epub 2021 May 14.

Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, "Carlo Urbani" Hospital, Via Aldo Moro 25, 60035 Jesi, Ancona, Italy.

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The role of TNFRSF11B in development of osteoarthritic cartilage.

Rheumatology (Oxford) 2021 May 14. Epub 2021 May 14.

Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Dept. Orthopaedics, LUMC.

Objectives: Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously identified with gain-of-function mutation in a family with early-onset OA with chondrocalcinosis, is among the highest upregulated genes in lesioned OA cartilage (RAAK-study). Here, we determined the role of TNFRSF11B overexpression in development of OA. Read More

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Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes.

Front Cell Dev Biol 2021 26;9:622287. Epub 2021 Apr 26.

Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Basic calcium phosphate (BCP)-based calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of the disease and hypertrophic differentiation of chondrocytes. Chondrocalcinosis (CC) is associated with calcium pyrophosphate dihydrate (CPPD) deposition disease in the joint inducing OA-like symptoms. There is only little knowledge about the effect of CPPD crystals on chondrocytes and the signaling pathways involved in their generation. Read More

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Identifying potential classification criteria for calcium pyrophosphate deposition disease (CPPD): Item generation and item reduction.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Division of Rheumatology, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, United States.

Objective: Classification criteria for calcium pyrophosphate deposition disease (CPPD) will facilitate clinical research on this common crystalline arthritis. We report on the first two phases of a four-phase process for developing CPPD classification criteria.

Methods: CPPD classification criteria development is overseen by a 12-member Steering Committee. Read More

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Experience and impact of crystal pyrophosphate deposition (CPPD) from a patient and caregiver perspective: A qualitative exploration from the OMERACT CPPD working group.

Semin Arthritis Rheum 2021 Jun 21;51(3):655-660. Epub 2021 Apr 21.

Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.

Objective: To explore the lived experience of people with calcium pyrophosphate deposition (CPPD) disease and the impact of this condition on their daily lives.

Methods: Patients with CPPD and their caregivers were invited to take part in a one-to-one (patient only) or paired (patient and caregiver) semi-structured interview. Interviews covered patients' diagnosis and treatment experiences, and the impact of CPPD on their daily lives. Read More

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Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca channel internalization in mesenchymal stem cells.

Bone Res 2020 Apr 26;8(1):19. Epub 2020 Apr 26.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

The loss-of-function mutations in the ALPL result in hypophosphatasia (HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Read More

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Calcium pyrophosphate deposition disease of the temporomandibular joint invading the middle cranial fossa: Two case reports.

World J Clin Cases 2021 Apr;9(11):2662-2670

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Background: Pseudogout is a benign joint lesion caused by the deposition of calcium pyro-phosphate dihydrate crystals, but it is invasive. Pseudogout of the temporo-mandibular joint (TMJ) is uncommon, and it rarely invades the skull base or penetrates into the middle cranial fossa. The disease has no characteristic clinical manifestations and is easily misdiagnosed. Read More

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[Prevalence of hypophosphatasia in adult patients in rheumatology].

Z Rheumatol 2021 Apr 14. Epub 2021 Apr 14.

Klinik für Innere Medizin III, Onkologie, Hämatologie, Rheumatologie und Klinische Immunologie, Universitätsklinikum Bonn, Venusberg Campus 1, 53127, Bonn, Deutschland.

Background: Hypophosphatasia (HPP) is a genetic disorder caused by one or more mutations in the alkaline phosphatase (ALP) gene, responsible for encoding tissue-specific ALP and for the mineralization process.

Objective: Identification of the prevalence of HPP in rheumatology patients.

Material And Methods: Medical records of all adult rheumatology patients with pathologically low total ALP levels (<35 U/L) treated in the Department of Rheumatology at the Clinic of Internal Medicine III, University Hospital Bonn between January 2017 and June 2019, were retrospectively examined for clinical signs as well as for results of genetic tests for HPP. Read More

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20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Rheumatology, Tripler Army Medical Center, Honolulu, HI 96859, USA.

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Read More

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Simultaneous Homozygous Mutations in and in an Inbred Chinese Pedigree.

Genes (Basel) 2021 Mar 5;12(3). Epub 2021 Mar 5.

Department of Nephrology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Long-quan Branch, Longquan 323716, China.

Gitelman syndrome (GS) and Bartter syndrome (BS) type III are both rare, recessively inherited salt-losing tubulopathies caused by and mutations, respectively. We described a 48-year-old male patient with fatigue, carpopedal spasm, arthralgia, hypokalemic alkalosis, mild renal dysfunction, hypomagnesemia, hypocalciuria, hyperuricemia, normotension, hyperreninemia and chondrocalcinosis in knees and Achilles tendons. His parents are first cousin. Read More

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The Incidence and Significance of Calcium Pyrophosphate Dihydrate Deposits in Histologic Examinations of Total Hip, Knee, and Shoulder Joint Arthroplasties.

Arch Pathol Lab Med 2021 Mar 15. Epub 2021 Mar 15.

From the Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio (Dermawan, Kilpatrick, Reith).

Context.—: The incidence, distribution, and significance of calcium pyrophosphate dihydrate deposition (CPPD) disease have not been extensively compared among various total joint resections.

Objective. Read More

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Interleukin-1 Blockade in Polygenic Autoinflammatory Disorders: Where Are We now?

Front Pharmacol 2020 26;11:619273. Epub 2021 Jan 26.

Department of Paediatric and Adult Rheumatology, University Hospital Motol, Prague, Czechia.

Polygenic autoinflammatory diseases (AIDs), such as systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease, Kawasaki disease, idiopathic recurrent pericarditis (IRP), Behçet's Syndrome, Crystal-induced arthropatihes such as gout or Calcium pyrophosphate deposition disease are characterized by the overexpression of inflammasome-associated genes, leading to a dysregulation of the innate immune response. The IL-1 cytokine family (IL-1α, IL-1β, IL-1Ra, IL-18, IL-36Ra, IL-36α, IL-37, IL-36β, IL-36g, IL-38, IL-33) was defined to be principally responsible for the inflammatory nature of polygenic AIDs. Several clinical trials were initiated, and IL-1 blockade has been proven to cause a rapid reduction of clinical symptoms and normalization of laboratory parameters in the majority of cases. Read More

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January 2021

Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2021 Mar 6. Epub 2021 Mar 6.

Department of Orthopedic Surgery and Traumatology, Kantonsspital Baselland, 4101, Bruderholz, Switzerland.

Purpose: There are contentious data about the role calcium pyrophosphate (CPP) crystals and chondrocalcinosis (CC) play in the progression of osteoarthritis (OA), as well as in the outcomes after knee arthroplasty. Hence, the purpose of this systematic review was to analyse the clinical and functional outcome, progression of OA and prosthesis survivorship after unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in patients with CC compared to patients without CC.

Methods: A systematic review of the literature in PubMed, Medline, Embase and Web of Science was performed using the "Preferred Reporting Items for Systematic Reviews and Meta-Analysis" (PRISMA) guidelines. Read More

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Intradural calcium pyrophosphate dihydrate deposition disease: case report.

J Neurosurg Spine 2021 Mar 5:1-4. Epub 2021 Mar 5.

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout, is a crystalline arthropathy that usually affects large joints and periarticular tissue. Spinal involvement is rare and is usually limited to extradural articular and periarticular structures. Only one case of intradural disease has been previously reported. Read More

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Drugs Recommended in Adult Rheumatic Diseases, But Considered for Off-Label Use in Argentina.

Reumatol Clin (Engl Ed) 2021 Feb 24. Epub 2021 Feb 24.

Servicio de Reumatología, Hospital J. M. Ramos Mejia, Urquiza 609, Ciudad Autónoma de Buenos Aires, Argentina.

Background: Off-label (OL) drug use is the prescription of a drug for indications other than those authorised in its technical datasheet. The objective of this study was to identify drugs recommended in rheumatology but considered for off-label use in Argentina.

Methods: A list of medications for certain selected rheumatic conditions was compiled. Read More

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February 2021

Iliopsoas Bursitis Related to Calcium Pyrophosphate Deposition Disease.

Intern Med 2021 Feb 15. Epub 2021 Feb 15.

Department of General Internal Medicine, Akashi Medical Center, Japan.

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February 2021

The diagnostic value of conventional radiography and musculoskeletal ultrasonography in calcium pyrophosphate deposition disease: a systematic literature review and meta-analysis.

Osteoarthritis Cartilage 2021 05 10;29(5):619-632. Epub 2021 Feb 10.

Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy. Electronic address:

Objective: To examine and compare the accuracy of conventional radiography (CR) and musculoskeletal ultrasonography (US) in the diagnosis of calcium pyrophosphate (CPP) crystals deposition disease (CPPD).

Design: A systematic search of electronic databases (PubMed, Embase, and Cochrane), conference abstracts and reference lists was undertaken. Studies which evaluated the accuracy of CR and/or US in the diagnosis of CPPD, using synovial fluid analysis (SFA), histology or classification criteria as reference tests were included. Read More

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Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model.

Arthritis Rheumatol 2021 Feb 8. Epub 2021 Feb 8.

Medical College of Wisconsin and Milwaukee VA Medical Center, Milwaukee.

Objective: The gene TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease (CPDD). While the CCA1 OPG mutation (OPG-XL) was originally believed to be a gain-of-function mutation, loss of OPG activity causes arthritis-associated osteolysis in mice, which is likely related to excess subchondral osteoclast formation and/or activity. The purpose of the present study was to further explore the effect of OPG-XL in osteoclastogenesis. Read More

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February 2021

Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.

Theranostics 2021 1;11(7):3074-3088. Epub 2021 Jan 1.

State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Multiscale Research Institute of Complex Systems, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan University, Shanghai 200433, China.

Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition. In situ and chemical-specific histological identification of MSU is crucial in the diagnosis and management of gout, yet it remains inaccessible for current histological methods. Stimulated Raman scattering (SRS) microscopy was utilized to image MSU based on its fingerprint Raman spectra. Read More

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January 2021

Cervical myeloradiculopathy as an initial presentation of pseudogout.

Neurosciences (Riyadh) 2021 Jan;26(1):93-96

From the Department of Anesthesiology (Liao), Division of Neurosurgery (Hsieh), Department of Surgery Sijhih Cathay General Hospital, from the Department of Medicine (Hsieh), School of Medicine, Fu Jen Catholic University, New Taipei, from the Department of Neurological Surgery (Hsieh Sun), Tri-Service General Hospital, National Defense Medical Center, New Taipei, from the Section of Neurosurgery (Huang, Sun), Department of Surgery, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, and from the Department of Biotechnology (Sun), Asia University, Taichung, Taiwan.

Pseudogout, also known as calcium pyrophosphate deposition disease, is an inflammatory arthropathy that primarily occurs in the peripheral joints, such as the knee or elbow. Spinal pseudogout is uncommon, and neck pain is its most common clinical manifestation. However, cervical myeloradiculopathy as an initial presentation of pseudogout attack of the ligamentum flavum has rarely been reported in the literature. Read More

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January 2021

Outcome domains reported by patients, caregivers, healthcare professionals and stakeholders for calcium pyrophosphate deposition (CPPD): A content analysis based on semi-structured qualitative interviews from the OMERACT CPPD working group.

Semin Arthritis Rheum 2021 Jun 6;51(3):650-654. Epub 2021 Jan 6.

Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.

Introduction: Although calcium pyrophosphate deposition (CPPD) disease is common, there are no validated outcome measures for clinical research in this condition. The aim of this study was to generate a list of outcome domains as reported by patients, their caregivers, healthcare professionals (HCPs) and stakeholders to inform the development of an Outcome Measures in Rheumatology (OMERACT) Core Domain Set for CPPD.

Methods: Patients with CPPD and their caregivers, HCPs and stakeholders took part in semi-structured qualitative interviews to explore potential outcome domains for CPPD clinical research relevant to their lived experience and knowledge of CPPD. Read More

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Arthroscopic Superior Capsule Reconstruction for Cuff Tear Arthropathy (Hamada Grade 5): A Case Report.

JBJS Case Connect 2020 12 21;10(4):e20.00511. Epub 2020 Dec 21.

Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.

Case: We performed arthroscopic superior capsule reconstruction (ASCR) for cuff tear arthropathy (CTA) with humeral head deformity. A 62-year-old man presented with severely limited shoulder motion and recalcitrant omalgia. He had a history of dental implant removal due to metal allergy, and his Constant score was 21 points. Read More

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December 2020