Search Our Scientific Publications & Authors

Cureus 2019 Jan 7;11(1):e3840. Epub 2019 Jan 7.

Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.

Calcium pyrophosphate disease (CPPD) is caused by the deposition of calcium pyrophosphate (CPP) crystals in the joint tissues, particularly fibrocartilage and hyaline cartilage. CPP crystals trigger inflammation, causing local articular tissue damage. Our review article below covers different aspects of CPPD. Read More

J Orthop 2019 Mar-Apr;16(2):128-132. Epub 2019 Feb 27.

Department of Orthopaedic Surgery, Japan Community Healthcare Organization, Kyushu Hospital, Fukuoka, Japan.

Arch Endocrinol Metab 2019 Feb;63(1):89-93

Emory University School of Medicine, Diabetes and Endocrinology Section, Atlanta, GA, USA.

Hypophosphatasia is a rare inborn error of metabolism characterized by low serum alkaline phosphatase activity due to loss-of-function mutations in the gene encoding the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Extracellular accumulation of TNSALP substrates leads to dento-osseous and arthritic complications featuring tooth loss, rickets or osteomalacia, and calcific arthopathies. Mild hypophosphatasia usually has autosomal dominant inheritance, severe cases are either autosomal recessive or due to a dominant negative effect. Read More

Bone 2019 Feb 28;122:231-236. Epub 2019 Feb 28.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Hypophosphatasia (HPP) is the inborn-error-of-metabolism characterized enzymatically by insufficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and caused by either mono- or bi-allelic loss-of-function mutation(s) of the gene ALPL that encodes this cell surface phosphomonoester phosphohydrolase. In HPP, the natural substrates of TNSALP accumulate extracellularly and include inorganic pyrophosphate (PPi), a potent inhibitor of biomineralization. This PPi excess leads to rickets or osteomalacia in all but the most mild "odonto" form of the disease. Read More

Ann Clin Biochem 2019 Feb 27:4563219826169. Epub 2019 Feb 27.

4 Blood Sciences, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.

We report a 49-year-old woman with an acute swollen left knee due to acute pseudogout with chondrocalcinosis as a presenting feature of Gitelman syndrome due a novel homozygous mutation of the SLC12A3 gene. This report highlights the under-recognized importance of excluding metabolic disease, including Gitelman syndrome, in younger patients whose sole presenting feature may be chondrocalcinosis with or without pseudogout, as this may impact on management and risk of further episodes. We also suggest that chondrocalcinosis and hypomagnesaemia with or without hypokalaemia are diagnostic of Gitelman syndrome. Read More

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

A 75-year-old woman was admitted with urosepsis due to Escherichia coli infection. After improvement with a ureteral stent and antimicrobial agent, she complained of back pain and showed elevated inflammation marker levels. Arthralgia and arthritis of multiple peripheral joints were noted, and radiography indicated cartilage calcification. Read More

J Small Anim Pract 2019 Feb 18. Epub 2019 Feb 18.

Institute of Veterinary Pathology, Freie Universitaet Berlin, 14163, Berlin, Germany.

J Bone Jt Infect 2019 1;4(1):20-26. Epub 2019 Jan 1.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education. 200 1st St SW, Rochester, MN 55905.

Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR. Read More

Osteoarthritis Cartilage 2019 Feb 6. Epub 2019 Feb 6.

Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. Electronic address:

Objective: To assess the diagnostic performance of ultrasound (US) for calcium pyrophosphate deposition (CPPD) at the level of menisci, hyaline cartilage (HC), tendons, and synovial fluid (SF) of the knee, and to examine inter- and intra-observer reliability.

Design: We consecutively included patients with knee effusion over a 2-year period (43 patients with CPPD and 131 controls). All patients underwent SF analysis, conventional radiography (CR), and US examination using the Outcome Measures in Rheumatology (OMERACT) definition of the US characteristics of CPPD. Read More

Arthritis Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, University of Otago, Christchurch, New Zealand.

Objective: To determine whether novel multi-energy spectral photon-counting CT (SPCCT) imaging can detect and differentiate between monosodium urate (MSU), calcium pyrophosphate (CPP) and hydroxyapatite (HA) crystal deposits ex vivo.

Methods: A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain X-ray, dual-energy CT (DECT) and multi-energy SPCCT. Read More

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):413-431

From the HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian, Academy of Sciences, Debrecen (K.É.S., L.P., M.O., N.P., G.B., J.B.), Faculty of Medicine, University of Debrecen, Hungary.

Objective- Calcific aortic valve disease is a prominent finding in elderly and in patients with chronic kidney disease. We investigated the potential role of iron metabolism in the pathogenesis of calcific aortic valve disease. Approach and Results- Cultured valvular interstitial cells of stenotic aortic valve with calcification from patients undergoing valve replacement exhibited significant susceptibility to mineralization/osteoblastic transdifferentiation in response to phosphate. Read More

Lasers Med Sci 2019 Jan 21. Epub 2019 Jan 21.

2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Raman spectroscopy is a type of vibrational spectroscopy based on the inelastic scattering of photons, which has attracted much attention due to its potential clinical application in rheumatology. In this review, we discuss the typical spectral features of cartilage, bone, synovial fluid, and pathologic crystal deposits, as well as methods of amplifying the Raman signal of biofluids such as drop-coating deposition Raman spectroscopy. Further, applications of Raman and drop-coating deposition Raman spectroscopy in osteoarthritis are described, highlighting the clinical potential of these methods. Read More

Arthritis Care Res (Hoboken) 2018 Nov 26. Epub 2018 Nov 26.

Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences.

Objectives: To preliminarily explore the diagnostic potential of ultrasound (US) in detecting calcium pyrophosphate crystal (CPP) deposits at the hip joint in a cohort of patients with calcium pyrophosphate deposition disease (CPPD) which were previously evaluated by conventional radiography (CR); to assess the sensitivity and specificity as well as the agreement between US and CR in the evaluation of hip CPP crystal deposits.

Design: Fifty consecutive patients with "definite" CPPD and 40 age/sex/body mass index-matched disease controls who had undergone hip CR within the previous six months were enrolled. Bilateral hip US examination was carried out by one of the authors (A. Read More

Semin Arthritis Rheum 2018 Oct 14. Epub 2018 Oct 14.

Université Paris Diderot France, France; Department of Rheumatology, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris, 75010 Paris, France; INSERM U1132, Hôpital Lariboisière, Université Paris Diderot, France. Electronic address:

Background: Calcium pyrophosphate dihydrate deposition disease (CPPD) has been reported to involve the spine, but few systematic studies have been published.

Objective: To further characterize the spinal involvement with CPPD by a review of CPPD patients hospitalized in a rheumatology department.

Methods: We retrospectively reviewed data for patients consecutively admitted with a diagnosis of CPPD in the rheumatology department of Lariboisière hospital in Paris, France over 5 years by using a standardized protocol and electronic case report forms. Read More

Curr Cardiol Rev 2019 ;15(2):91-95

Fundacion Instituto de Investigacion Sanitaria, Fundacion Jimenez Diaz, Avenida Reyes Catolicos 2, Madrid, Spain.

Vascular calcification is a pathologic phenomenon consisting of calcium phosphate crystal deposition in the vascular walls. Vascular calcification has been found to be a risk factor for cardiovascular diseases, due to its correlation with cardiovascular events and mortality, and it has been associated with aging, diabetes, and chronic kidney disease. Studies of vascular calcification have focused on phosphate homeostasis, primarily on the important role of hyperphosphatemia. Read More

Int Wound J 2019 Apr 31;16(2):556-558. Epub 2018 Oct 31.

Division of Dermatology and Connective Tissue Medicine, National Center for Geriatrics and Gerontology, Obu, Japan.

Sudden-onset immobilisation generates unexpected external forces over bony prominences and is a potential cause of pressure ulcers. Here, we report two cases of deep pressure ulcers in patients with acute monoarthritis as a result of calcium pyrophosphate (CPP) crystal deposition (pseudogout). The patients were women in their 80 who could perform activities of daily living by themselves. Read More

BMJ Case Rep 2018 Oct 28;2018. Epub 2018 Oct 28.

Infectious Diseases, Blacktown Mount Druitt Hospital, Blacktown, New South Wales, Australia.

A case of a 67-year-old man with coexisting polyarticular septic arthritis due to group G , gout and pseudogout is presented. Septic arthritis of the left knee joint was further complicated by the development of an adjacent osteomyelitis. Appropriate management led to a full clinical recovery. Read More

BJR Case Rep 2018 7;4(1):20170049. Epub 2017 Oct 7.

Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University Hospital, Fukuoka, Japan.

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is characterized by the accumulation of CPPD crystal in articular and periarticular tissues, but CPPD crystal deposition along the spinal dura mater has not been previously reported. We report a 54-year-old male presenting with progressive neck pain and numbness of the extremities. CT showed diffuse dorsal epidural calcification from C3-T6 which resulted in spinal canal stenosis. Read More

Rev Med Interne 2018 Oct 19. Epub 2018 Oct 19.

Service de médecine interne, hôpital Avicenne, AP-HP, 93000 Bobigny, France.

Introduction: Chondrocalcinosis results from calcium pyrophosphate crystals deposition in the joints. We report an exceptional case of aseptic psoas abscess with a deposition of calcium pyrophosphate crystals.

Case Report: A 92-year-old man presented to our department for an acute onset of inflammatory pain in the left hip. Read More

J Craniofac Surg 2018 Nov;29(8):e792-e794

Department of Maxillofacial Surgery.

Background: The association between the synovial chondromatosis (SC) and the calcium pyrophosphate deposition (pseudogotta) in temporomandibular joint (TMJ) is very rare and has been described just 1 patient in the literature.

Clinical Presentation: A 64-year-old woman was referred to Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali, Sapienza Università di Roma after complaining about right temporomandibular pain, limitation in mandibular movements, and tumefaction in the right preauricular region. The patient was hospitalized for the surgery. Read More

J Med Ultrason (2001) 2019 Jan 16;46(1):137-146. Epub 2018 Oct 16.

Rheumatology Department, Università Politecnica delle Marche, "Carlo Urbani" Hospital, Iesi, Ancona, Italy.

Purpose: This study aimed at investigating the prevalence of crystal deposits with knee osteoarthritis (OA) by ultrasonography and measure the inflammatory burden associated with crystal deposits in OA using WOMAC score.

Methods: Adult patients with primary knee OA diagnosed according to the American College of Rheumatology criteria were included. Participants were subjected to history taking, clinical examination, knee US, and plain radiography. Read More

J Orthop Surg Res 2018 Oct 16;13(1):255. Epub 2018 Oct 16.

Lourdes Medical Center Burlington County, Willingboro, NJ, 08046, USA.

Clin Nucl Med 2019 Feb;44(2):e98-e100

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

A 53-year-old man with a 10-year history of gout was admitted to our hospital due to chronic low back pain. Initial CT examinations showed a high-density mass with bone destruction of bilateral facet joints at the L3 to L5 level. MRI findings also revealed lesion with the dural sac compression. Read More

J Shoulder Elbow Surg 2019 Jan 12;28(1):196-202. Epub 2018 Oct 12.

Institut Locomoteur de l'Ouest Saint Gregoire (Vivalto Sante), Saint Gregoire, France.

Background: This study evaluated the clinical and structural outcome 20 years after repair of isolated supraspinatus tendon tears. We hypothesized that the results would deteriorate over time.

Materials And Methods: For this retrospective multicenter study, 137 patients were recalled for a clinical and imaging assessment. Read More

Asian Spine J 2018 Dec 16;12(6):1117-1122. Epub 2018 Oct 16.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Study Design: Prospective study.

Purpose: To assess the prevalence of periodontoid calcification and its associations with acute cervical pain.

Overview Of Literature: Calcium pyrophosphate dihydrate (CPPD) deposition disease is a common rheumatological disorder that occurs especially in elderly patients. Read More

Am J Orthop (Belle Mead NJ) 2018 Sep;47(9)

Department of Orthopedic Surgery, Academic Medical Center, Amsterdam, The Netherlands.

Reverse total shoulder arthroplasty (RTSA) is a common treatment for rotator cuff tear arthropathy. We performed a systematic review of all the RTSA literature to answer if we are treating the same patients with RTSA, across the world. A systematic review was registered with PROSPERO, the international prospective register of systematic reviews, and performed with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines using 3 publicly available free databases. Read More

J Rheumatol 2018 Oct;45(10):1422-1423

Department of Medicine, Divisions of Infectious Diseases and Hospital Medicine, University of Missouri, Columbia, Missouri, USA.

RMD Open 2018 21;4(2):e000743. Epub 2018 Sep 21.

Université Paris Diderot, USPC, UFR de Médecine, Paris, France.

Objectives: To survey the undergraduate rheumatic and musculoskeletal diseases (RMDs) curriculum content in a sample of medical schools across Europe.

Methods: The undergraduate musculoskeletal diseases and disability curriculum of University of Nottingham, UK, was used as a template to develop a questionnaire on curriculum content. The questionnaire elicited binary (yes/no) responses and included the option to provide additional information as free text. Read More

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Medicine/Rheumatology, University of Kentucky, Lexington, Kentucky, USA.

We report a case of calcium pyrophosphate deposition disease (CPPD) with an unusual presentation of severe chondrocalcinosis with atypical large burden deposited in the metacarpophalangeal joints as well as more typical deposition in wrists and knees as demonstrated on plain radiographs. A 77-year-old African-American woman 1-year status post parathyroidectomy for hyperparathyroidism initially presented to the rheumatology clinic to treat suspected rheumatoid arthritis given her pattern of joint involvement but was found to have CPPD. The patient's history is notable for end-stage renal disease which complicates medical management. Read More

J Shoulder Elbow Surg 2018 Dec 26;27(12):2271-2283. Epub 2018 Sep 26.

Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

Massive rotator cuff tears may lead to the development of cuff tear arthropathy (CTA). Although this pathology has been recognized for more than 150 years, treatment strategies have continued to evolve. During the last decade, there has been increased understanding of the molecular and cellular changes that govern rotator cuff tear outcomes and development of new treatment strategies to repair or reconstruct the rotator cuff. Read More

Can Assoc Radiol J 2018 Nov 22;69(4):430-436. Epub 2018 Sep 22.

Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Purpose: To analyze the utilization, indications, and outcomes of dual-energy computed tomography (DECT) gout imaging in clinical practice.

Methods: This retrospective study was ethics approved. Radiology reports of DECT gout scans between 2007 and 2016 were analyzed for trends of utilization, referral pattern, indication, and diagnosis. Read More

J Shoulder Elbow Surg 2019 Jan 14;28(1):56-64. Epub 2018 Sep 14.

Upper Extremities Department, Schulthess Clinic, Zürich, Switzerland; Research and Development Department, Schulthess Clinic, Zürich, Switzerland. Electronic address:

Hypothesis: We hypothesized that treatment of rotator cuff arthropathy (RCA) with reverse shoulder arthroplasty (RSA) and an additional latissimus dorsi transfer (LDT) in patients with an active external rotation deficit (ERD) would restore external rotation (ER) with concomitant deterioration in internal rotation.

Methods: In our cohort study, 26 RCA patients with an active ERD (ie, positive lag sign and maximum active ER of 0°) underwent RSA between September 2007 and February 2015; LDT was completed in 13 of these patients. In addition, 88 control patients without ERD who underwent only RSA were identified. Read More

Maxillofac Plast Reconstr Surg 2018 Dec 3;40(1):19. Epub 2018 Aug 3.

4Department of Oral and Maxillofacial Radiology, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457 Republic of Korea.

Background: Calcium pyrophosphate dihydrate deposition disease (CPDD) is a rare disease in the temporomandibular joint (TMJ) space. It forms a calcified crystal mass and induces a limitation of joint movement.

Case Presentation: The calcified mass in our case was occupied in the left TMJ area and extended to the infratemporal and middle cranial fossa. Read More

Knee Surg Sports Traumatol Arthrosc 2018 Sep 10. Epub 2018 Sep 10.

Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.

Possible failures of autologous chondrocyte implantation (ACI), a cell-based technique for articular cartilage repair, are not always clinically apparent and the underlying mechanisms largely remain unknown. This case report presents the first scenario in the literature highlighting an association of a medium-term partial failure of an advanced ACI procedure (matrix-assisted ACI) in the knee with focal asymptomatic calcium pyrophosphate deposition disease, a common inflammatory pyrophosphate arthropathy. The specific presence of CPPDs, resulting from increased biomechanical stresses in the repair tissue-cartilage and repair tissue-subchondral bone integration sites, together with the absence of cartilage regeneration was identified and possibly contributed to the partial failure. Read More

Pathol Res Pract 2018 Oct 27;214(10):1661-1666. Epub 2018 Aug 27.

Department of Histopathology, NDORMS, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7HE, UK. Electronic address:

Background: Localised (transthyretin-associated) amyloid is commonly seen in articular/periarticular tissues of elderly individuals. Whether age-associated, amyloid deposition occurs in foot and ankle (F&A) tissues has not previously been investigated. In this study we assessed the nature and frequency of F&A amyloid deposition and determined whether it is associated with age and/or specific articular/periarticular F&A lesions. Read More

J Am Acad Orthop Surg 2018 Dec;26(24):e504-e510

From University of Utah, Salt Lake City, UT (Dr. Chalmers), Washington University in St. Louis, St. Louis, MO (Dr. Keener, Dr. Yamaguchi, Dr. Chamberlain), Loyola University, Chicago, IL (Dr. Salazar), and Rush University Medical Center, Chicago, IL (Dr. Romeo).

Introduction: The purpose of this study was to determine how reverse and total shoulder arthroplasty (RTSA and TSA) comparative utilization, postoperative diagnoses, demographics, and perioperative data have changed between 2005 and 2015.

Methods: This was a single-center retrospective review of all primary TSAs and RTSAs.

Results: Our cohort included 1,192 RTSAs and 1,600 TSAs. Read More

Clin Exp Rheumatol 2018 Jul 19. Epub 2018 Jul 19.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objectives: It is unclear whether attack recurrence rates are similar between acute calcium pyrophosphate (CPP) crystal arthritis and gout. This study compared the clinical features and recurrence rates of both conditions.

Methods: In this retrospective study, we reviewed 106 patients with acute CPP crystal arthritis (based on the presence of CPP crystals and/or chondrocalcinosis) and 173 patients with gout (based on the presence of monosodium urate crystals). Read More

Clin Rheumatol 2019 Feb 25;38(2):425-430. Epub 2018 Aug 25.

Service de Rhumatologie, Hôpital Bichat, APHP, Université Paris Diderot, 46 rue Henri Huchard, 75018, Paris, France.

Calcium pyrophosphate (CPP) deposition is a frequent joint disease with increased prevalence in older people in whom treatment of acute CPP arthritis with conventional therapies such as colchicine or non-steroidal anti-inflammatory drugs could be contraindicated or not used at an optimal dose. As recommended in gout, anakinra might represent an alternative treatment for arthritis. We aimed to analyze the efficacy and safety of anakinra in acute CPP arthritis in a large reported series. Read More

Dtsch Med Wochenschr 2018 Aug 7;143(16):1157-1166. Epub 2018 Aug 7.

The metabolic diseases gout and calciumpyrophosphate deposition (CPPD) (formerly: chondrocalcinosis/pseudogout) are crystal arthropathies which are caused by crystals in synovial fluid and in the case of gout also in periarticular structures. Today, in particular gout is considered as an auto-inflammatory process since phagocytosis of monosodium urate crystals by monocytes/macrophages results in the activation of the innate immune system by activation of the NRLP3-Inflammasome and consecutive secretion of the key cytokine interleukin-1ß and other pro-inflammatory cytokines. The prevalence of both crystal arthropathies rises with increasing age of patients. Read More

Reumatol Clin 2018 Jul 26. Epub 2018 Jul 26.

Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, España.

Rev Neurol (Paris) 2018 Dec 24;174(10):671-674. Epub 2018 Jul 24.

Unité de soins intensifs neuro-vasculaires et réseau bourgogne-AVC, CHU de Dijon Bourgogne, 14, rue Paul-Gaffarel, 21079 Dijon cedex, France.

Pain after stroke (PAS) is a common clinical problem that is both underdiagnosed and undertreated. Yet, it induces depression and cognitive troubles, and impairs quality of life. To provide tools for practitioners, this report describes the most common PAS syndromes, including central post-stroke pain, spasticity and contractures, shoulder pain and complex regional pain syndromes, as well as headache and chondrocalcinosis, along with their risk factors, their prevention and their specific treatments. Read More

EFORT Open Rev 2018 06 6;3(6):363-373. Epub 2018 Jun 6.

Department of Orthopaedic Surgery, La Paz University Hospital - IdiPaz, Spain.

An age younger than 60 years, a body weight of 180 lb (82 kg) or more, performing heavy work, having chondrocalcinosis and having exposed bone in the patellofemoral (PF) joint are not contraindications for unicompartmental knee arthroplasty (UKA).Severe wear of the lateral facet of the PF joint with bone loss and grooving is a contraindication for UKA.Medial UKA should only be performed in cases of severe osteoarthritis (OA) as shown in pre-operative X-rays, with medial bone-on-bone contact and a medial/lateral ratio of < 20%. Read More

J Med Case Rep 2018 Jul 5;12(1):205. Epub 2018 Jul 5.

Rheumatology Department, Hédi Chaker University Hospital, El-Aïn Street Km 0,5, zip code 3029, Sfax, Tunisia.

Background: Septic arthritis is an infectious disease that commonly affects weight-bearing or proximal joints such as the knee and the hip. The sternoclavicular joint is an unusual site of this entity. It usually occurs in patients with diabetes mellitus, intravenous drug abusers, or those with rheumatoid arthritis. Read More

Int J Rheum Dis 2018 Jul;21(7):1391-1397

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: Chondrocalcinosis results from deposition of calcium pyrophosphate dihydrate in articular cartilage. It is a relatively common radiographic finding of the joints, especially the knee. This study investigated the incidence and the risk factors for the development of knee chondrocalcinosis in the general population. Read More

BMJ Case Rep 2018 Jun 20;2018. Epub 2018 Jun 20.

Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin Campus Virchow-Klinikum, Berlin, Germany.

In the field of traumatic shoulder dislocations, this report of a 61-year-old female patient discusses the case of an acute locked superior shoulder dislocation in conjunction with a chronic rotator cuff arthropathy resulting from a low-energy fall on the outstretched and abducted arm. Radiological assessment revealed a complex combination of associated bony injuries including a fracture of the upper part of the glenoid and an impaction fracture of the inferior articular surface of the humeral head. Closed reduction and immobilisation were not successful in obtaining joint stability. Read More

PLoS One 2018 13;13(6):e0198104. Epub 2018 Jun 13.

Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Tissue calcification is an important physiological process required for the normal structure and function of bone. However, ectopic or excessive calcification contributes to diseases such as chondrocalcinosis, to calcium deposits in the skin or to vascular calcification. SMOC2 is a member of the BM-40/osteonectin family of calcium-binding secreted matricellular proteins. Read More

Front Immunol 2018 28;9:1145. Epub 2018 May 28.

School of Biochemistry and Immunology, School of Medicine, Trinity College Dublin, Trinity Biomedical Sciences Institute, The University of Dublin, Dublin, Ireland.

It is now well established that intra-articular deposition of endogenous particulates, such as osteoarthritis-associated basic calcium phosphate crystals, gout-associated monosodium urate crystals, and calcium deposition disease-associated calcium pyrophosphate crystals, contributes to joint destruction through the production of cartilage-degrading enzymes and pro-inflammatory cytokines. Furthermore, exogenous wear-debris particles, generated from prosthetic implants, drive periprosthetic osteolysis which impacts on the longevity of total joint replacements. Over the last few years, significant insight has been gained into the mechanisms through which these particulates exert their effects. Read More

Int Immunopharmacol 2018 Aug 8;61:197-203. Epub 2018 Jun 8.

Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra-Ibarra (INR-LGII), Calz. México-Xochimilco No. 289, Col. Arenal de Guadalupe, Delegación Tlalpan, C.P. 14389 Ciudad de México, Mexico.

The anti-inflammatory and immunomodulatory effects of nanoparticles in several chronic diseases have been extensively researched. The aim of this review is to examine how nanoparticles modulate the inflammatory pathways that characterize the most prevalent forms of microcrystal-induced arthritis, including gout, pseudogout, and BCP-induced arthritis. The nanoparticles of chitosan-coated calcium phosphate, uricase, aceclofenac, and gold have been investigated in crystal-inducedarthritis. Read More

Insights Imaging 2018 Aug 7;9(4):477-492. Epub 2018 Jun 7.

Department of Radiology, Radio-Oncology and Nuclear Medicine, Centre hospitalier de l'Université de Montréal, 1000 rue Saint-Denis, Montréal, QC, H2X 0C1, Canada.

Musculoskeletal calcifications are frequent on radiographs and sometimes problematic. The goal of this article is to help radiologists to make the correct diagnosis when faced with an extraosseous musculoskeletal calcification. One should first differentiate a calcification from an ossification or a foreign body and then locate the calcification correctly. Read More

Arthritis Res Ther 2018 05 30;20(1):104. Epub 2018 May 30.

Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Background: Meniscal calcification is considered to play a relevant role in the pathogenesis of osteoarthritis of the knee. Little is known about the biology of acetabular labral disease and its importance in hip pathology. Here, we analyze for the first time the calcification of the acetabular labrum of the hip (ALH) and its relation to hip cartilage degeneration. Read More