1,704 results match your criteria Calciphylaxis


Calciphylaxis and Ulcerative Lesions of Bilateral Nipple-Areolar Complex Due to Alcoholic Liver Disease.

Indian J Radiol Imaging 2022 Mar 1;32(1):142-144. Epub 2022 May 1.

Department of Gastroenterology and Hepatology, Grande International Hospital, Dhapasi, Kathmandu, Nepal.

When faced with eczematous lesions involving the nipple-areolar complex (NAC), Paget's disease is assumed to be the diagnosis, anything else being considered a "Zebra" necessitating its exclusion on pathology. A middle-aged lady presented with synchronous asymmetrical ulceration of bilateral NAC with pleomorphic calcifications on mammography and simultaneous extensive vascular calcification in bilateral breasts that suggested systemic cause. Calciphylaxis is a rare diagnosis occurring usually due to underlying end-stage renal disease or hyperparathyroidism. Read More

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Calciphylaxis: A Long Road to Cure with a Multidisciplinary and Multimodal Approach.

Case Rep Nephrol 2022 8;2022:3818980. Epub 2022 Jun 8.

Department of Nephrology, National and Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.

Calciphylaxis is a rare yet potentially fatal condition, resulting from ectopic calcification of the small arterioles of the dermis with resulting necrotic lesions infection, sepsis, and death. In hemodialysis patients, its prevalence ranges between 1 and 4%, while mortality amounts to 30-80%. We present in here a 45-year-old female on chronic dialysis with morbid obesity, who was admitted for painful nodules in the lower abdomen and necrotic lesions at the lower extremities. Read More

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Hemodialysis Patient with Streptococcal Toxic Shock Syndrome and Penile Necrosis: A Case Report.

Intern Med 2022 May 31. Epub 2022 May 31.

Department of Nephrology, Omihachiman Community Medical Center, Japan.

A 72-year-old man on hemodialysis due to diabetic nephropathy presented with a fever and penile pain. Although his physical examination was unremarkable, his general condition deteriorated. Penile necrosis was observed by evening on the same day of presentation, and the patient died the next morning. Read More

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Use of the optimized sodium thiosulfate regimen for the treatment of calciphylaxis in Chinese patients.

Ren Fail 2022 Dec;44(1):914-922

Institute of Nephrology, Zhong Da Hospital, Southeast University, School of Medicine, Nanjing, China.

Background: Sodium thiosulfate (STS) can be used to treat patients diagnosed with calciphylaxis, which is a rare life-threatening syndrome. However, our patients treated with the recommended STS regimen presented with serious adverse events, resulting in treatment withdrawal. Then an optimized STS regimen was used to increase the tolerance of patients to STS and improve treatment continuation. Read More

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December 2022

A diabetic patient with finger gangrene.

Eur J Intern Med 2022 May 20. Epub 2022 May 20.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan; Department of Diabetes and Endocrinology, Mutsu General Hospital, Aomori 035-0071, Japan.

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Penectomy to manage penile gangrene caused by calciphylaxis, a case report.

Urol Case Rep 2022 May 11;42:102029. Epub 2022 Feb 11.

Urology Department, King Hamad University Hospital, Bahrain.

Penile calciphylaxis is a condition associated with end stage renal disease that presents a diagnostic and management challenge. We present a case of a 43 year old male with end stage renal disease on dialysis who was managed by partial penectomy and survived 19 months post operatively. We discuss the available management options as well as the prognosis and outcomes of the condition while advocating for a patient tailored management plan. Read More

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Management of chronic urinary retention in glanular penile calciphylaxis.

Urol Case Rep 2022 May 24;42:102016. Epub 2022 Jan 24.

Department of Urology, Manchester Royal Infirmary, United Kingdom.

Urinary retention in penile calciphylaxis is a rare phenomenon due to its association with end-stage renal failure. A 48 year-old male was noted to have a lesion with necrotic appearances overlying his urethral meatus with increasing bladder volumes. He is on haemodialysis for end-stage renal failure and was being treated for infected calciphylaxis ulcers on his thigh. Read More

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Nonuremic calciphylaxis manifesting with diffuse dermal angiomatosis.

JAAD Case Rep 2022 Jun 4;24:8-10. Epub 2022 Apr 4.

Department of Dermatology, University of California San Francisco, California.

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[Uremic calciphylaxis].

Nephrol Ther 2022 Jun 2;18(3):180-188. Epub 2022 May 2.

Service d'explorations fonctionnelles rénales, AURA Nord Saint-Ouen, Saint-Ouen, université Paris V, hôpital Necker, René Descartes, Paris, France.

Uremic calciphylaxis is a rare disease that affects patients with chronic end-stage renal disease. It is a pathology of the microvessels of the dermis and hypodermis which are calcified and whose thrombosis leads to skin necrosis. Calciphylaxis lesions can be distal and axial. Read More

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Case Report: Idiopathic Subcutaneous Thrombotic Vasculopathy.

Front Med (Lausanne) 2022 15;9:843793. Epub 2022 Apr 15.

Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, United States.

Lower extremity ulcers have significant morbidity, with treatment determined by the underlying disorder. Reported is a 32-year-old female presenting with small skin nodules and bruises across her legs 4 weeks following her second COVID vaccination. These lesions progressed into large, necrotic ulcers over several months. Read More

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Chronic inflammation and calciphylaxis.

BMJ Case Rep 2022 Apr 29;15(4). Epub 2022 Apr 29.

Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA

Calciphylaxis also known as calcific uraemic arteriolopathy is a rare condition mostly seen in patients with end-stage kidney disease. We report a case of a simultaneous-kidney-pancreas transplant patient with functioning grafts developing biopsy-proven calciphylaxis in the setting of chronic inflammation. Despite several modalities of management, the patient developed progression of her disease leading to multiple amputations. Read More

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Penile calciphylaxis: rare and unrecognized disease.

Pan Afr Med J 2022 13;41:124. Epub 2022 Feb 13.

Service of Urology, Military Hospital of Instruction Mohamed V, Hay Ryad, Rabat, Morocco.

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Calciphylaxis a Giant Cell Arteritis Mimic: A Case Report and Review of the Literature.

J Neuroophthalmol 2022 03 18;42(1):e362-e366. Epub 2021 Aug 18.

McGovern Medical School at the University of Texas Health Science Center (AD), Houston, Texas; Department of Ophthalmology (NB, SHB, PC-B, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Department of Pathology and Genomic Medicine (PC-B), Houston Methodist Hospital, Houston, Texas; Department of Pathology and Laboratory Medicine (PC-B), Weill Medical College of Cornell University, New York, New York; Department of Pathology and Laboratory Medicine (PC-B), the University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (PC-B, AGL), Baylor College of Medicine. Houston, Texas; The Houston Methodist Research Institute (AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology Weill Cornell Medicine (AGL), New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), the University of Iowa Hospitals and Clinics, Iowa City, Iowa.

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Comments on "Ultrasound findings of calciphylaxis".

Kidney Int 2022 05;101(5):1085

Institute of Nephrology, Zhong Da Hospital, Southeast University, School of Medicine, Nanjing, China.

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Identifying subcutaneous tissue microcalcification by Fluo-3 AM imaging in cutaneous calciphylaxis.

Exp Dermatol 2022 Apr 20. Epub 2022 Apr 20.

Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is typically characterized by subcutaneous tissue calcification and excruciatingly painful cutaneous lesions with high mortality. It is critical for dermatologists to make early diagnosis and appropriate management, yet currently only 56% of calciphylaxis cases are correctly diagnosed by conventional histological stain1. Specially, the identification of subtle calcium deposits of subcutaneous can be challenging but is believed crucial for early diagnosis of calciphylaxis2. Read More

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The Relevance of Skin Biopsies in General Internal Medicine: Facts and Myths.

Dermatol Ther (Heidelb) 2022 May 17;12(5):1103-1119. Epub 2022 Apr 17.

Department of Dermatology, University Hospital Centre, CHU du Sart Tilman, University of Liège, 4000, Liège, Belgium.

Introduction: Non-dermatology medical specialties may refer patients for skin biopsies, searching for a particular diagnosis. However, the diagnostic impact of the skin biopsy is not clearly established. This article aims to assess the indications for, and evaluate the clinical relevance of, skin biopsies in non-dermatology medical specialties. Read More

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Rheopheresis: A narrative review.

Int J Artif Organs 2022 May 7;45(5):445-454. Epub 2022 Apr 7.

AURA Sante, Pole Santé République, Clermont Ferrand, France.

Introduction: Rheopheresis is an extracorporal selective double-filtration procedure with an initial separation of plasma from the whole blood and a further filtration of the plasma through a second filter in order to eliminate a certain number of high molecular weight proteins such LDL, Lp(a), fibrinogen, α2-macroglobulin, Factor von Willebrand, and IgM Immunoglobulin.

Methods: In this narrative review we discuss the available data on the effects of Rheopheresis in various clinical conditions.

Results: Rheopheresis is considerd to exert a rapid effect on clinical conditions associated with seriously affected microcirculation and rheologic parameters such as, the dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHS), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis and diabetic foot. Read More

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Nonuremic Calciphylaxis Precipitated by COVID-19 Infection.

Cureus 2022 Mar 3;14(3):e22796. Epub 2022 Mar 3.

Internal Medicine, Henry Ford Health System, Detroit, USA.

Calciphylaxis is a rare dermatologic condition that is primarily associated with end-stage renal disease (ESRD). Nonuremic calciphylaxis has been reported in patients with autoimmune disorders such as systemic lupus erythematosus and other hypercoagulable states such as anti-phospholipid syndrome. New research throughout the COVID-19 pandemic has shown an increased inflammatory and coagulopathic complication of COVID-19. Read More

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Ulceration and Necrosis of Fingers and Toes in an ESKD Patient.

Kidney360 2021 06 24;2(6):1074-1075. Epub 2021 Jun 24.

Nephrology, St. James Hospital, Dublin, Ireland.

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Retinal artery and vein occlusion in calciphylaxis.

Am J Ophthalmol Case Rep 2022 Jun 25;26:101433. Epub 2022 Mar 25.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.

Purpose: To report a case of branch retinal artery occlusion (BRAO) followed by branch retinal vein occlusion (BRVO) and paracentral acute middle maculopathy (PAMM) in a patient with confirmed calciphylaxis.

Observations: A 52-year-old female with a history of BRAO in the right eye one-year prior presented with decreased vision and a new inferotemporal scotoma. Computed tomography angiography of the head and neck demonstrated vascular calcifications at the origin of both ophthalmic arteries, which were otherwise poorly visualized. Read More

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Development of calciphylaxis in kidney transplant recipients with a functioning graft.

Clin Kidney J 2022 Apr 26;15(4):663-671. Epub 2021 Oct 26.

Nephrology and Renal Transplantation Department, Hospital Clínic, Barcelona, Spain.

Background: Calciphylaxis is not uniquely observed in uraemic patients, as some cases have also been reported in patients with normal renal function or moderate chronic kidney disease (CKD), in association with severe vasculopathy or systemic inflammation. A particular subset worthy of studying is represented by those patients who develop calciphylaxis after kidney transplantation (KT).

Methods: Analysis of the local series of calciphylaxis after KT ( = 14) along with all the other cases reported in the literature from 1969 to 2019 ( = 31), for a total population of 45 patients, is presented. Read More

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Calciphylaxis after kidney transplantation: a rare but life-threatening disorder.

Clin Kidney J 2022 Apr 15;15(4):611-614. Epub 2021 Dec 15.

Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy.

Calciphylaxis is a rare disorder characterized by vascular calcification and thrombosis of the subcutaneous microcirculation, leading to painful necrotic skin lesions and bearing a dreadfully high mortality rate. This syndrome is frequently also termed uraemic calcific arteriolopathy, since most cases are observed in patients with kidney failure. However, it is increasingly clear that calciphylaxis may also affect patients with normal or only slightly impaired renal function, including kidney transplant recipients. Read More

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Cutaneous vascular calcification. Perieccrine calcification as a diagnostic key for calciphylaxis.

J Cutan Pathol 2022 Mar 31. Epub 2022 Mar 31.

Dermatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.

Background: Attempts have been made to establish discriminative criteria between classic calciphylaxis (CPX) and those cases in which cutaneous vascular calcification (CVC) represents an incidental finding (epiphenomenon).

Methods: Retrospective, observational cohort study of patients with CVC to distinguish clinicopathological features between CVC as classic CPX (CVC in cutaneous lesions with erythematous-violaceous plaques with or without ulceration) or as an epiphenomenon (CVC in cutaneous lesions with known diagnosis). Different clinicopathological parameters and the presence of perieccrine calcification and pseudoxanthoma elasticum (PXE)-like changes were evaluated. Read More

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Chronic skin ulcer in a maintenance hemodialysis patient: pyoderma gangrenosum or calciphylaxis?

Int Urol Nephrol 2022 Mar 29. Epub 2022 Mar 29.

Department of Nephrology, The Affiliated Hospital of Southwest Medical University, 25th Taiping Street, Luzhou, 646000, Sichuan, China.

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Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation.

EBioMedicine 2022 Apr 22;78:103954. Epub 2022 Mar 22.

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland. Electronic address:

Background: Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (HS), mainly produced in blood vessels by the enzyme cystathionine- γ-lyase (CSE), inhibits IH in pre-clinical models. Read More

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Concurrent development of encapsulating peritoneal sclerosis and calciphylaxis in a patient with peritoneal dialysis for end-stage renal disease.

BMJ Case Rep 2022 Mar 23;15(3). Epub 2022 Mar 23.

Swindon Renal Unit, Great Western Hospital Foundation NHS Trust, Swindon, UK.

Both encapsulating peritoneal sclerosis (EPS) and calciphylaxis are rare but severe complications involving patients with end-stage renal disease. In this report, we discuss a unique case of a 73-year-old female patient who had undergone 8 years of peritoneal dialysis for IgA nephropathy and concurrently developed these two synchronous complications within 3 months of each other. Diagnosis and management of both conditions were discussed in detail as well as the possible association between the two. Read More

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Non-uremic Calciphylaxis and Parathyroid Adenoma, An Uncommon Association Requiring Early Recognition.

Indian J Dermatol 2021 Nov-Dec;66(6):690-692

Department of Dermatology, Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, México E-mail:

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Metabolic Disorders Associated with Renal Disease in Horses.

Vet Clin North Am Equine Pract 2022 Apr 10;38(1):109-122. Epub 2022 Mar 10.

Littleton Equine Medical Center, 8025 South Santa Fe Drive, Littleton, CO 80120, USA. Electronic address:

This article overviews metabolic disorders associated with renal disease. Included is a discussion of the pathophysiology, clinical signs, and treatment of hyperchloremic metabolic acidosis associated with renal tubular acidosis. Conditions affecting the central nervous system including uremic encephalopathy and hyponatremic encephalopathy secondary to renal disease are presented. Read More

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A novel model of dermatomyositis induced by membrane antigen and calciphylaxis in rats.

Biomed Rep 2022 Apr 24;16(4):31. Epub 2022 Feb 24.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, P.R. China.

Dermatomyositis (DM) is a severe autoimmune disease of the connective tissue characterized by inflammatory and degenerative changes in the skin and muscle. However, the lack of experimental models of DM represents a challenge for the development of effective drugs. The aim of the present study was to establish a pharmacodynamic rat model of DM that would recapitulate the clinical manifestation seen in patients. Read More

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[Treatment of acute and chronic ulcers].

Ugeskr Laeger 2022 02;184(8)

Steno Diabetes Center Odense, Odense Universitetshospital.

Chronic ulcers are most often seen as a complication to venous leg ulcers, diabetic foot ulcers and pressure ulcers. Ulcers often display an underlying medical condition, which makes it mandatory to treat these individuals in a multidisciplinary setting. Modern ulcer therapy has changed over the latest decade, and as described in this review a number of new modalities have been included. Read More

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February 2022