1,518 results match your criteria Calciphylaxis


Clinical Characteristics and Outcomes of Patients with Calciphylaxis.

Am J Med Sci 2020 Jul 15. Epub 2020 Jul 15.

Division of Nephrology, Department of Medicine, Albany Medical College, 25 Hackett Blvd, Albany, New York 12208, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjms.2020.07.017DOI Listing

A case of calciphylaxis with an unfavorable outcome.

An Bras Dermatol 2020 Jul 15. Epub 2020 Jul 15.

Department of Dermatology, Universidade Federal Fluminense, Niterói, RJ, Brazil; Department of Dermatopathology, Universidade Federal Fluminense, Niterói, RJ, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abd.2020.02.012DOI Listing

Assessment of outcomes of calciphylaxis lesions treated with intralesional sodium thiosulfate.

J Am Acad Dermatol 2020 Jul 28. Epub 2020 Jul 28.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

● Calciphylaxis is a serious disorder with high morbidity and mortality and no approved therapy. Intralesional sodium thiosulfate (ILSTS) has not been well-studied as a treatment modality. ● This retrospective study identifies ILSTS as a potentially effective treatment option for calciphylaxis with few adverse effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.07.090DOI Listing

Isolated Mesenteric Calciphylaxis With Ischemic Colitis in a Hemodialysis Patient Without Active Cutaneous Calciphylaxis: A Case Report of Calcific Uremic Arteriolopathy.

Kidney Med 2020 Mar-Apr;2(2):209-212. Epub 2020 Feb 22.

Renal Unit, Flinders Medical Centre, South Australia, Australia.

Calciphylaxis, also known as calcific uremic arteriolopathy, is a devastating systemic disease most commonly associated with chronic kidney failure. Its hallmark histopathologic features of small-vessel calcification, intimal hyperplasia, and microthrombi lead to microvascular occlusion and tissue necrosis. Clinically, it typically presents with painful cutaneous lesions that may be distal or proximal, with proximal lesions associated with higher mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xkme.2019.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380420PMC
February 2020

Role of Phosphate in Biomineralization.

Calcif Tissue Int 2020 Jul 25. Epub 2020 Jul 25.

Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Henry Ford Hospital, New Center One; Suite # 800, Detroit, MI, 48202, USA.

Inorganic phosphate is a vital constituent of cells and cell membranes, body fluids, and hard tissues. It is a major intracellular divalent anion, participates in many genetic, energy and intermediary metabolic pathways, and is important for bone health. Although we usually think of phosphate mostly in terms of its level in the serum, it is needed for many biological and structural functions of the body. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-020-00729-9DOI Listing

Calciphylaxis-Associated Cutaneous Vascular Calcification in Noncalciphylaxis Patients.

Am J Dermatopathol 2020 Aug;42(8):557-563

Attending Pathologist, Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Calciphylaxis is a highly morbid disease that is strongly associated with chronic kidney disease (CKD); however, the histologic criteria for diagnosis have not been well established nor have their specificity for calciphylaxis been determined. This retrospective study aimed to examine the prevalence of histologic features commonly associated with calciphylaxis in noncalciphylaxis patients. We also sought to evaluate whether these features may be more prevalent in patients with CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001519DOI Listing

Extracutaneous Manifestations of Calciphylaxis: Ogilvie's Syndrome With Perforation.

Am Surg 2020 May;86(5):546-548

110230 Burn Surgery, U.S. Army Institute of Surgical Research, Fort Sam Houston, TX, USA.

Calciphylaxis or calcific uremic arteriolopathy is a rare entity associated with the end-stage renal disease that presents with necrotic cutaneous lesions that may require surgical management. Extracutaneous manifestations of calciphylaxis including visceral ischemia have been reported; however, surgical intervention for colonic ischemia has only been reported twice. We report a 49-year-old male with calciphylaxis who subsequently developed Ogilvie's syndrome complicated by perforation requiring total abdominal colectomy with end ileostomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0003134820919736DOI Listing

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease.

BMC Nephrol 2020 Jul 16;21(1):279. Epub 2020 Jul 16.

Department of Nephrology, The Royal Melbourne Hospital, 300 Grattan St, Parkville, Victoria, 3050, Australia.

Background: Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disease (CKD), especially in those with end-stage kidney disease (ESKD) on dialysis. Medial calcification is particularly prevalent in this population and contributes to arterial stiffness and increased cardiovascular mortality and morbidity. Apart from in the setting of calciphylaxis, few studies have assessed skin and subcutaneous calcification and associations with abnormalities of bone and mineral metabolism in patients with CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01928-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364566PMC

Calciphylaxis in Systemic Lupus Erythematosus: A Diagnostic Challenge.

J Clin Rheumatol 2020 Jul 7. Epub 2020 Jul 7.

School of Medicine Federal University of Juiz de Fora Juiz de Fora Minas Gerais, Brazil. Department of Morphology Federal University of Juiz de Fora José Lourenço Kelmer Juiz de Fora Minas Gerais, Brazil. Department of Pathology Fluminense Federal University Niterói Rio de Janeiro, Brazil. Division of Rheumatology Hospital Santa Casa de Misericórdia de Juiz de Fora (SCMJF); Department of Pharmacology Federal University of Juiz de Fora José Lourenço Kelmer Juiz de Fora Minas Gerais, Brazil

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001467DOI Listing

Multiple extremity necrosis in fatal calciphylaxis: Case report.

J Bras Nefrol 2020 Jul 8. Epub 2020 Jul 8.

Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Departamento de Medicina, São Paulo, SP, Brazil.

Introduction: The clinical impact of vascular calcification is well established in the context of cardiovascular morbidity and mortality, but other clinical syndromes, such as calciphylaxis, although less frequent, have a significant impact on chronic kidney disease.

Methods: Case report of a 27-year-old woman, who had complained of bilateral pain in her toes for 3 days, with the presence of small necrotic areas in the referred sites. She had a history of type 1 diabetes (25 years ago), with chronic kidney disease, on peritoneal dialysis, in addition to rheumatoid arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-2020-0025DOI Listing

Calciphylaxis unilateralis: The role of underlying peripheral vascular disease cannot be ignored.

Australas J Dermatol 2020 Jul 7. Epub 2020 Jul 7.

National Skin Centre, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13392DOI Listing

Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology.

Am J Dermatopathol 2020 Jul;42(7):471-480

Assistant Professor, Departments of Pathology and Dermatology, University of California, San Francisco, CA.

Calciphylaxis is a cutaneous vasculopathy with high morbidity and mortality characterized by vascular intimal fibrosis, calcification, stenosis, thrombosis, and eventual tissue death due to ischemia. Histopathologic diagnosis is often difficult, frequently necessitating multiple tissues samples due to lack of specific histopathologic features and subtle changes on biopsies of early lesions. In this study, we review the reported clinical and histopathologic features of calciphylaxis, correlating them with relevant imaging, ancillary studies, and pathophysiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001526DOI Listing

Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis.

Br J Pharmacol 2020 Jun 18. Epub 2020 Jun 18.

Sanifit Therapeutics, Palma, Spain.

Background And Purpose: No therapy is approved for vascular calcification or calcific uremic arteriolopathy (calciphylaxis), which increase mortality and morbidity in patients undergoing dialysis. Deposition of hydroxyapatite (HAP) crystals in arterial walls is the common pathophysiologic mechanism. These experiments examined the mechanism of action of SNF472 to reduce HAP deposition in arterial walls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.15163DOI Listing

Mimicry of surgical site infection - Case report.

Int J Surg Case Rep 2020 29;72:212-214. Epub 2020 May 29.

University Centre for Orthopaedics and Trauma Surgery, University Hospital Carl Gustav Carus Dresden and Faculty of Medicine of Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address:

Background Context: Calciphylaxis is a rare complication of secondary hyperparathyroidism caused by calcifications of small blood vessels in the skin and soft tissue. The disease occurs almost exclusively in patients with chronic kidney disease and has an incidence of approximately 50 cases per year in Germany [1].

Purpose: We present a case of a 61-year-old woman with calciphylaxis in connection with a primary knee endoprosthesis implantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298546PMC

Calciphylaxis in the Setting of Hemodialysis, Liver Cirrhosis, and Warfarin Therapy for Atrial Fibrillation: An Argument for Alternative Anti-Embolic Therapy.

Cureus 2020 May 7;12(5):e8014. Epub 2020 May 7.

Division of Nephrology, Hypertension, and Transplant, Augusta University Medical College of Georgia, Augusta, USA.

Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare, life-threatening cutaneous systemic disease that typically occurs in the setting of end-stage renal disease (ESRD). ESRD is the most recognized risk factor for calciphylaxis but it is not the sole risk factor. Calciphylaxis has also been associated with liver cirrhosis with or without concurrent renal disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279680PMC

Diagnosing Calciphylaxis: A series of cases with both imaging and tissue biopsy.

J Am Acad Dermatol 2020 Jun 8. Epub 2020 Jun 8.

Division of Dermatology, University of Vermont Medical Center, Burlington, Vermont.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.111DOI Listing

The role of skin biopsy in diagnosis and management of calciphylaxis: a retrospective analysis.

J Am Acad Dermatol 2020 May 29. Epub 2020 May 29.

Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School. Boston, MA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.101DOI Listing

Penile necrosis by calciphylaxis leading to gangrene in a patient with chronic renal failure on dialysis: A case report.

Int J Surg Case Rep 2020 11;71:187-191. Epub 2020 May 11.

Department of Urology, Mohamed VI University Hospital, Oujda, Morocco.

Introduction: Penile calciphylaxis is a rare disease whose diagnosis is not easy. It is associated with chronic renal failure. It is a result of media calcification and blood vessels' fibrosis such as penile arteries that eventually lead to gangrene formation in extremities and penis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.04.091DOI Listing

Nonuremic Calciphylaxis.

J Clin Rheumatol 2020 Jun;26(4):e83-e84

From the American University of the Caribbean, Coral Gables, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000000899DOI Listing

Calciphylaxis in a Patient on Home Hemodialysis.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620922718

Ashland Bellefonte Cancer Center, Ashland, KY, USA.

Calciphylaxis is a rare and severe complication characterized by calcification of arterioles and capillaries in the dermis and subcutaneous adipose tissue that leads to ischemia, necrosis, and painful skin lesions in patients with end-stage renal disease (ESRD). It is also known as calcific uremic arteriolopathy. Calciphylaxis occurs most commonly with the ESRD with skin ulceration as a predominant presenting feature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620922718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243381PMC

Penile calciphylaxis: A retrospective case-control study.

J Am Acad Dermatol 2020 May 15. Epub 2020 May 15.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Calciphylaxis is a rare disorder characterized by skin necrosis caused by calcium deposition within vessels, thrombosis, and subsequent tissue ischemia. Penile involvement may rarely occur.

Objective: To identify risk factors, diagnosis, management, and mortality of patients with penile calciphylaxis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.042DOI Listing
May 2020
4.449 Impact Factor

Pain reduction by dehydrated human amnion/chorion membrane allograft in nondiabetic leg ulcers might be an early indicator of good response: A case series.

Dermatol Ther 2020 May 14:e13587. Epub 2020 May 14.

Department of Dermatology, University Hospital Basel, Basel, Switzerland.

Dehydrated human amnion/chorion membrane allograft (dHACM) derived from placenta is increasingly used for skin and soft tissue repair in several medical specialties. Promising effects of dHACM were also reported in chronic venous and diabetic leg ulcers. However, dHACM is cost-intensive and its effect on chronic leg ulcers of other etiologies and pain reduction is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13587DOI Listing

Nonuremic calciphylaxis in a patient with multiple myeloma and rheumatoid arthritis.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):556-560

Department of Nephrology, Mohamed VI Medical Center, Marrakesh, Morocco.

Calciphylaxis is a rare and highly morbid condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. Calciphylaxis predominantly affects patients with chronic kidney disease treated by dialysis but is also described in patients with normal kidney function. We report a rare case of a patient who presented with calciphylaxis associated with multiple myeloma and rheumatoid arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1319-2442.284038DOI Listing

A Detailed Analysis of the Distribution, Morphology, and Histopathology of Complex Purpura in Hospitalized Patients: A Case Series of 68 Patients.

J Am Acad Dermatol 2020 May 3. Epub 2020 May 3.

Yale School of Medicine Department of Dermatology and; Department of Pathology, New Haven, Connecticut. Electronic address:

Background: Purpura in inpatients commonly leads to dermatologic consultation. The differential diagnosis is broad and algorithms are intricate.

Objective: We evaluated inpatient consultations for complex purpura to document the most common diagnoses and to validate the true diagnostic utility of histopathology, clinical morphology, and distribution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.04.149DOI Listing

An unusual presentation of calciphylaxis.

Cutis 2020 Mar;105(3):E24-E27

Department of Dermatology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.

View Article

Download full-text PDF

Source

Ischemia of the Penis and Fingertips Secondary to Calcifying Uremic Arteriolopathy.

Cureus 2020 Mar 31;12(3):e7481. Epub 2020 Mar 31.

Urology, Hassan II University Hospital Center/Sidi Mohammed Ben Abdellah University, Fez, MAR.

Calcifying uremic arteriolopathy (CUA), also called calciphylaxis, refers to the calcification of the walls of the arteries of medium and small caliber, causing ischemic skin lesions. Diagnosis should be made if ischemic lesion develops in a patient with chronic renal failure (CRF), and it is confirmed based on clinical, radiological, and histological criteria. Generalized CUA characterized by ischemia of the penis (IP) along with other localizations of cutaneous ischemia is exceptional, and the morbidity and high mortality rate associated with this entity most often warrant multidisciplinary and conservative management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188450PMC

A 52-Year-Old Female with Multiple Swellings in Both Hands: Idiopathic Calcinosis Cutis.

Cureus 2020 Mar 30;12(3):e7471. Epub 2020 Mar 30.

Medicine, All India Institute of Medical Sciences, Jodhpur, IND.

Calcinosis cutis is a rare disorder characterized by deposition of insoluble calcium salts in skin and subcutaneous tissue. Depending upon the aetiology, there are five subtypes of calcinosis cutis described in the literature; dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Idiopathic calcinosis cutis is rarely described in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188000PMC

Partial Penectomy for Dry Penile Gangrene in a Patient With Penile Calciphylaxis.

Urology 2020 Jul 27;141:e3-e4. Epub 2020 Apr 27.

Department of Urology, University of Arizona College of Medicine Tucson, Tucson, AZ.

Penile calciphylaxis is a difficult urologic condition to manage. First described by Wood et al in 1997, penile calciphylaxis is a rare cause of penile gangrene. One study found the overall mortality rate associated with penile calciphylaxis to be 64%, with a mean time to death of 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2020.04.072DOI Listing

Sodium-Thiosulfate Induced Life-Threatening Metabolic Acidosis Limiting Treatment of Calciphylaxis.

Am J Case Rep 2020 Apr 27;21:e919926. Epub 2020 Apr 27.

Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.

BACKGROUND Calcific uremic arteriolopathy (CUA) is a rare and incredibly painful cutaneous disorder secondary to microvascular involvement in which calcium dysregulation leads to stenosis of medium sized arterial blood vessels along with endothelial dysregulation and thrombosis. Ultimately, these patients are at high risk for non-healing wounds with risk of death from sepsis and multi-organ failure. It is a poorly understood condition with limited therapies that do not offer mortality benefit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.919926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200089PMC

Calciphylaxis: An Analysis of Concomitant Factors, Treatment Effectiveness and Prognosis in 30 Patients.

Int J Nephrol Renovasc Dis 2020 5;13:65-71. Epub 2020 Apr 5.

Department of Medicine - Division of Nephrology, University of Missouri School of Medicine, Columbia, MO 65212, USA.

Background: Calciphylaxis is a rare but severe complication mostly affecting patients with end-stage renal disease (ESRD) and is associated with high morbidity and mortality. The natural history, concomitant factors, pathogenesis, and treatment for calciphylaxis remain equivocal.

Methods: We conducted a retrospective study on patients diagnosed with calciphylaxis in a tertiary care center between January 1, 2012, and December 31, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJNRD.S241422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147606PMC

Nonuraemic cutaneous calciphylaxis: our experience with a challenging disease.

Clin Exp Dermatol 2020 Aug 18;45(6):745-746. Epub 2020 May 18.

Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.14242DOI Listing

Penile Calciphylaxis: A Rare Case of Penile Lesion.

Indian J Nephrol 2020 Mar-Apr;30(2):138-140. Epub 2020 Jan 3.

Department of Internal Medicine, Saint Vincent Hospital, 123 Summer Street Worcester, Massachusetts, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijn.IJN_135_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132857PMC
January 2020

A Case of Early Calciphylaxis Diagnosed by Bone Scan.

Case Rep Med 2020 17;2020:9526836. Epub 2020 Mar 17.

Nephrology, Department of Nephrology, Changzhou First People's Hospital, Changzhou, China.

Calcium uremic aortic disease (calciphylaxis) has long been considered as a rare, life-threatening small vessel disease. The diagnosis of calciphylaxis depends mainly on clinical symptoms and high risk factors, and skin biopsy can be used to confirm the diagnosis. However, noninvasive testing methods are still the focus of exploration currently. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/9526836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103050PMC

Dermatoscopy in life-threatening and severe acute rashes.

Clin Dermatol 2020 Jan - Feb;38(1):113-121. Epub 2019 Nov 11.

Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy.

A prompt recognition of life-threatening and severe acute rashes is of utmost importance to start an appropriate therapy as soon as possible. Consequently, clinicians often must rely only on clinical data to make a diagnosis because some diagnostic procedures may take a relatively long time to be performed (eg, histologic examination, microbiologic tests). In this scenario, dermatoscopy may be useful as an auxiliary tool to support the diagnosis by highlighting subclinical features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clindermatol.2019.10.013DOI Listing
November 2019

Penile Calciphylaxis.

Urology 2020 Jun 16;140:e8-e9. Epub 2020 Mar 16.

Urgences Néphrologiques et Transplantation Rénale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Paris, France; Sorbonne Université, Paris, Île-de-France, France; Inserm, UMRS_1155, Paris, Île-de-France, France.

The proposed image reports the case of penile calciphylaxis. Calciphylaxis is a rare obliterative small vessel vasculopathy associated with diabetes mellitus, end-stage renal disease. Penile involvement is even rarer with only 50 cases reported, and agreement on appropriate diagnosis and management is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2020.03.003DOI Listing

Epidemiology and Treatment of Calcinosis Cutis: 13 Years of Experience.

Indian J Dermatol 2020 Mar-Apr;65(2):105-111

Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Background: Calcinosis cutis is a rare condition associated with different diseases, which is difficult to manage.

Aims And Objectives: In this retrospective study, the epidemiology of calcinosis cutis and the effectiveness of various treatment regimens in its management were assessed in a single center.

Materials And Methods: The data of 34 patients suffering from calcinosis cutis (male:female = 12:22; mean age = 48. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.IJD_527_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059479PMC

Hyperbaric oxygen therapy in patients suffering from wounds in calciphylaxis: a narrative review.

Undersea Hyperb Med 2020 First Quarter;47(1):111-123

Professor of Anesthesiology/Hyperbaric Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Calcific uremic arteriolopathy (calciphylaxis) is a rare and highly lethal vascular disease. Vascular calcification with calcium depositions lead to ischemic ulcers associated with gangrene, severe pain and poor healing. Although hyperbaric oxygen (HBO2) therapy has been used in the treatment of calciphylaxis, evidence of its effectiveness is limited. Read More

View Article

Download full-text PDF

Source

Calciphylaxis in Association with Alcoholic Cirrhosis and Hepatorenal Syndrome.

Skinmed 2020 1;18(1):46-49. Epub 2020 Jan 1.

Department of Dermatology, Hofstra Northwell School of Medicine, Manhasset, NY;

A 45-year-old woman with cirrhosis secondary to alcohol abuse was transferred from an outside hospital for management of a painful cutaneous eruption, progressively worsening over 2 weeks. On examination, the patient was a middle-aged white woman lying in bed in no acute distress, with jaundice and a protuberant abdomen consistent with ascites. The patient was afebrile (98. Read More

View Article

Download full-text PDF

Source
January 2020

Calciphylaxis of the fingers.

J Gen Fam Med 2020 Mar 22;21(2):25-26. Epub 2020 Jan 22.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

A 69-year-old Japanese man with a 10-year history of hemodialysis for end-stage renal disease presented with painful necrosis of the fingers of his right hand. A plain radiograph of the right hand revealed severely calcified arteries, particularly in the ring finger, suggesting the diagnosis of calciphylaxis of the fingers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgf2.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060295PMC

Calciphylaxis: looking for clues beyond skin biopsy.

Int Urol Nephrol 2020 May 3;52(5):991-992. Epub 2020 Mar 3.

Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-020-02424-yDOI Listing
May 2020
1.293 Impact Factor

Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: a case-control study.

BMC Nephrol 2020 02 26;21(1):63. Epub 2020 Feb 26.

Department of Nephrology and Immunology, Institute of Transplantation Urology and Nephrology, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Background: Calcific Uremic Arteriolopathy (CUA) is a rare disease, causing painful skin ulcers in patients with end stage renal disease. Recommendations for CUA management and treatment are lacking.

Methods: We conducted a retrospective cohort study on CUA cases identified in western France, in order to describe its management and outcome in average clinical practices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01722-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045437PMC
February 2020

Nonuremic calciphylaxis triggered by rapid weight loss and hypotension.

Cutis 2020 Jan;105(1):E11-E14

Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, Michigan, USA.

Calciphylaxis is a potentially fatal disease caused by metastatic calcification of the small- and medium-sized blood vessels of the dermis and subcutis. It most commonly is seen in patients with renal disease requiring dialysis, but it also may be triggered by nonuremic causes in patients with known risk factors for calciphylaxis. We report a case of nonuremic calciphylaxis (NUC) occurring in the setting of multiple risk factors, including chronic corticosteroid use, obesity, rapid weight loss, and hypotension. Read More

View Article

Download full-text PDF

Source
January 2020

Calciphylaxis resulting in acute coronary syndrome through calcified nodule formation.

Eur Heart J 2020 Feb 14. Epub 2020 Feb 14.

Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, 454, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehaa088DOI Listing
February 2020

Calciphylaxis: A Deceiving Cellulitis.

Cureus 2019 Dec 30;11(12):e6518. Epub 2019 Dec 30.

Internal Medicine, The University of Texas Health Science Center/Christus Good Shepherd Medical Center, Longview, USA.

Calciphylaxis is a rare and serious disorder seen most in end-stage renal disease (ESRD) patients on dialysis. It is associated with the calcium deposits in small and medium blood vessels of the skin and subcutaneous tissues resulting in painful skin lesions, plaques, ulcerations, gangrene, and secondary infections. The aim of our present report is to create awareness and encourage providers to consider calciphylaxis in the differential diagnosis of cellulitis in the appropriate clinical setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.6518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988719PMC
December 2019

Differential diagnosis of calciphylaxis in chronic dialysis patients.

Int Urol Nephrol 2020 Mar 1;52(3):595-597. Epub 2020 Feb 1.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-020-02388-zDOI Listing

[AT THE BOTTOM OF THE ULCER - THE IMPORTANCE OF A BIOPSY IN DIAGNOSING HARD TO TREAT ULCERS].

Harefuah 2020 Jan;159(1):21-24

Department of Dermatology, Rambam Health Care Campus, Haifa.

Introduction: We report a case of a patient who presented with bilateral chronic painful necrotic leg ulcers. A skin biopsy revealed histopathological findings compatible with calciphylaxis, a rare phenomenon accompanied by high morbidity and mortality. Treatment options are limited and are based mainly on case reports and small series, so further research is needed in this area. Read More

View Article

Download full-text PDF

Source
January 2020

The color of skin: purple diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):528-547. Epub 2019 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vessel vasculitis, immunoglobulin A (IgA) vasculitis, cryoglobulinemia, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosum, warfarin-induced skin necrosis, heparin-induced thrombocytopenia, purpura fulminans, antiphospholipid antibody syndrome, calciphylaxis, levamisole-induced vasculopathy, and thrombotic thrombocytopenic purpura. Dermatologists play a central role in treating patients with cutaneous vasculitis and vasculopathy and may have the opportunity to facilitate identification of systemic disease by diagnosing cutaneous vasculitis and vasculopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clindermatol.2019.07.016DOI Listing

The color of skin: black diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):447-467. Epub 2019 Aug 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Gradations in skin color are a consequence of differing amounts of melanin and their varying distribution. Although many darkly pigmented skin lesions are melanocytic and can be attributed to melanin content, the color of a black lesion can also be due to blood, necrotic tissue, or exogenous pigment. The source, pattern, and distribution of the color in black lesions usually offer important insight into its etiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clindermatol.2019.08.003DOI Listing

Hybrid image (SPECT/CT) in the early diagnosis of a patient with calciphylaxis.

Nefrologia 2019 Dec 28. Epub 2019 Dec 28.

Servicio de Medicina Nuclear, Hospital Universitario Virgen del Rocío, Sevilla, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nefro.2019.11.003DOI Listing
December 2019

Calciphylaxis: Challenges in the diagnosis and management.

J Family Med Prim Care 2019 Dec 10;8(12):4044-4045. Epub 2019 Dec 10.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfmpc.jfmpc_852_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924228PMC
December 2019