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    Early clinical presentations and progression of calciphylaxis.
    Int J Dermatol 2017 Apr 23. Epub 2017 Apr 23.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Background: Untreated calciphylaxis is a fatal disease of intra- and extravascular calcification, most commonly presenting in end-stage renal disease (ESRD) patients. While early identification is critical for timely treatment, early-stage clinical and histopathological descriptions have not, to our knowledge, been elucidated. As early clinical recognition is essential to prompt definitive histopathological diagnosis, this study describes a range of clinical and histopathological manifestations of early-stage calciphylaxis. Read More

    A case report of severe calciphylaxis - suggested approach for diagnosis and treatment.
    BMC Nephrol 2017 Apr 21;18(1):137. Epub 2017 Apr 21.
    Department of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg-Straße 1, 30635, Hannover, Germany.
    Background: Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. Read More

    Calciphylaxis Presenting with Various Symptoms: A Case Report.
    Case Rep Dermatol 2017 Jan-Apr;9(1):25-29. Epub 2017 Feb 8.
    Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.
    Calciphylaxis causes ischemia in multiple organs and skin ulcers owing to progressive calcification in small and medial arteries. It has a poor prognosis and often occurs in patients with hyperparathyroidism associated with end-stage renal failure and those undergoing hemodialysis. Here, we present a case of calciphylaxis associated with a wide range of symptoms, including lower thigh skin ulcers, a rectovaginal fistula, and femoral neck fracture. Read More

    Calciphylaxis: Beyond CKD-MBD.
    Nefrologia 2017 Apr 5. Epub 2017 Apr 5.
    Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
    Introduction: Calcific uraemic arteriolopathy (CUA), also called calciphylaxis, is a rare but potentially fatal vascular disorder that almost exclusively affects patients with chronic renal failure. The objective of this study was to analyse various risk factors for developing CUA and its subsequent clinical course according to the treatment received.

    Materials And Methods: A retrospective study that included patients diagnosed with CUA from December 1999 to December 2015. Read More

    Fractures in calciphylaxis patients following intravenous sodium thiosulfate therapy.
    J Eur Acad Dermatol Venereol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA.
    Calciphylaxis is a highly fatal syndrome of small vessel calcification that results in skin ischemia and necrosis.[1] Affected patients present with extremely painful, violaceous skin lesions that progress to non-healing ulcers, and can be complicated by superimposed infections and sepsis.[2] The mortality rate from calciphylaxis is estimated at 60-80%. Read More

    Curr Opin Nephrol Hypertens 2017 Apr 1. Epub 2017 Apr 1.
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Purpose Of Review: Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calciphylaxis.

    Recent Findings: The most recent estimate places the incidence of calciphylaxis at 3. Read More

    Benefits of intralesional injections of sodium thiosulfate in the treatment of calciphylaxis.
    Int Wound J 2017 Mar 21. Epub 2017 Mar 21.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Calciphylaxis (CPX) is a rare calcifying thrombotic vasculopathy responsible for painful necrotic ulcers, with a high mortality rate, and its management is often difficult. Recently, intravenous infusions of sodium thiosulfate (STS) have shown efficacy. The aim of this study was to assess the efficacy of intralesional STS (IL STS) in four patients. Read More

    Metaplastic ossification of the temporal artery with osteoclast-like giant cells: a mimicker of giant cell (temporal) arteritis.
    Eur J Ophthalmol 2017 Feb 28. Epub 2017 Feb 28.
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY - USA.
    Purpose: To describe a patient presenting with suspected giant cell (temporal) arteritis (GCA) in whom subsequent temporal artery biopsy showed luminal narrowing by medial calcification, metaplastic ossification, and fibrointimal proliferation, consistent with calciphylaxis.

    Methods: A 55-year-old man with end-stage renal disease presented with unilateral loss of vision and elevated erythrocyte sedimentation rate and was initially treated as though he had GCA; however, a subsequent temporal artery biopsy showed marked luminal narrowing by medial calcification, metaplastic ossification, and fibrointimal proliferation, consistent with calciphylaxis. In addition, the tunica media of the affected artery contained multinucleate giant cells, but these represented osteoclasts and foreign body giant cells reacting to calcium, rather than a part of GCA. Read More

    Calciphylaxis: Comparison of radiologic imaging and histopathology.
    J Am Acad Dermatol 2017 Mar 9. Epub 2017 Mar 9.
    Department of Department of Hyperbaric Medicine and Wound Healing, Greenwich Hospital, Greenwich, Connecticut.
    Background: The current gold standard for diagnosis of calciphylaxis is a skin biopsy specimen demonstrating calcification of small-caliber arteries or arterioles.

    Objective: The aim of this study is to compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis.

    Methods: We conducted a retrospective study of patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images taken as part of their routine care. Read More

    Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis.
    J Eur Acad Dermatol Venereol 2017 Mar 2. Epub 2017 Mar 2.
    Department of Dermatology, Universitätsklinikum Erlangen, Erlangen, Germany.
    Background: Livedoid vasculopathy and calciphylaxis are rare skin disorders. Large cohorts of patients have been missing so far for detailed analysis.

    Patients And Methods: Data from diagnosis-related groups (DRGs) of hospitalized cases of livedoid vasculopathy (ntotal = 1357) and calciphylaxis (ntotal = 699) were analysed for the years 2008-2013 concerning sex, age and frequency of diagnosis. Read More

    Calciphylaxis on bone scan: correlation between molecular and cross-sectional findings.
    Radiol Case Rep 2017 Mar 24;12(1):175-178. Epub 2016 Dec 24.
    Department of Radiology, MSC 10-5530, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.
    Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity with the classic clinical presentation and imaging features of this rare entity may help its early identification and treatment. Read More

    Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy.
    S Afr Med J 2017 Jan 30;107(2):140-144. Epub 2017 Jan 30.
    Division of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
    Background: Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage renal disease (ESRD) on haemodialysis, but may rarely occur in the absence of ESRD in conditions such as primary hyperparathyroidism, malignancy, alcoholic liver disease and connective tissue disease.

    Methods: We reviewed the records of all patients diagnosed with calciphylaxis while on renal replacement therapy at Tygerberg Hospital, Cape Town, South Africa, between 1990 and 2014, to describe its presentation, course and final outcome. Read More

    Vasculitic and autoimmune wounds.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 14;5(2):280-292. Epub 2016 Dec 14.
    Division of Rheumatology, The George Washington University, School of Medicine and Health Sciences, Washington, D.C.
    Objective: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions. Read More

    Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry.
    PLoS One 2017 17;12(2):e0172407. Epub 2017 Feb 17.
    Department of Medicine, Division of Nephrology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
    Introduction: Calciphylaxis/calcific uremic arteriolopathy affects mainly end-stage kidney disease patients but is also associated with malignant disorders such as myeloma, melanoma and breast cancer. Genetic risk factors of calciphylaxis have never been studied before.

    Methods: We investigated 10 target genes using a tagging SNP approach: the genes encoding CD73/ ecto-5'-nucleotidase (purinergic pathway), Matrix Gla protein, Fetuin A, Bone Gla protein, VKORC1 (all related to intrinsic calcification inhibition), calcium-sensing receptor, FGF23, Klotho, vitamin D receptor, stanniocalcin 1 (all related to CKD-MBD). Read More

    A Case of Nonuremic Calciphylaxis in a Caucasian Woman.
    Case Rep Dermatol Med 2017 16;2017:6831703. Epub 2017 Jan 16.
    Canberra Hospital, ACT Health, Canberra, ACT, Australia.
    We report a case of nonuremic calcific arteriolopathy (NUCA) in an 82-year-old Caucasian woman from rural Australia. The patient had no history of kidney disease or dialysis. NUCA is rare disease suspected on cutaneous and clinical features and diagnosed by characteristic findings on skin biopsy and vasculature imaging. Read More

    Conservative management of distal leg necrosis in lung transplant recipients.
    J Tissue Viability 2017 Jan 28. Epub 2017 Jan 28.
    Division of Pulmonology, University Hospital of Zurich, Switzerland. Electronic address:
    Critical limb ischemia (CLI) with distal leg necrosis in lung transplant recipients (LTR) is associated with a high risk for systemic infection and sepsis. Optimal management of CLI has not been defined so far in LTR. In immunocompetent individuals with leg necrosis, surgical amputation would be indicated and standard care. Read More

    Warfarin-Associated Nonuremic Calciphylaxis.
    JAMA Dermatol 2017 Mar;153(3):309-314
    Department of Dermatology, University of California-San Francisco, San Francisco.
    Importance: Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated calciphylaxis, present data from 2 others from our institution, and review all cases of warfarin-associated calciphylaxis available in the literature. Read More

    Patient Outcomes and Factors Associated with Healing in Calciphylaxis Patients Undergoing Adjunctive Hyperbaric Oxygen Therapy.
    J Am Coll Clin Wound Spec 2015 Dec 30;7(1-3):8-12. Epub 2016 Aug 30.
    Department of Emergency Medicine, Division of Hyperbaric Medicine and Wound Care, SUNY Upstate Medical University, 550 East Genesee Street, Suite 103, Syracuse, NY 13202, USA.
    Calcific uremic arteriolopathy, also known as calciphylaxis, is a rare syndrome of small vessel calcification of unknown etiology causing painful, violaceous skin lesions that progress to form chronic non-healing ulcers and gangrene. Hyperbaric oxygen therapy (HBOT) can be used as adjunctive therapy in the treatment of these ulcers. However, due to paucity of cases, there is limited data on the clinical benefit of HBOT and identifying factors associated with healing. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jan 3. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases.
    Joint Bone Spine 2016 Dec 7. Epub 2016 Dec 7.
    Pôle locomoteur, service de rhumatologie, centre Viggo Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris 7 Denis Diderot, Paris Cité Sorbonne, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:
    Intravenous sodium thiosulfate (ivSTS) is a promising new therapeutic option for calciphylaxis related to end-stage renal disease. However, its effect on tumoral calcinosis (TC) complicating autoimmune connective-tissue diseases has been scarcely described. We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. Read More

    Ischemic myopathy revealing systemic calciphylaxis.
    Muscle Nerve 2016 Dec 9. Epub 2016 Dec 9.
    Reference Center for Neuromuscular Diseases, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris (APHP); INSERM U955-Team 10, Université Paris Est-Créteil, 94 Avenue du Marechal de Lattre de Tassigny, 94010, Creteil, France.
    Introduction: Patients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure-associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life-threatening condition usually observed in patients with end-stage renal disease on chronic dialysis or after renal transplantation.

    Methods: We describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis. Read More

    Penile calcific uremic arteriolopathy occurring postparathyroidectomy in a hemodialysis patient.
    Saudi J Kidney Dis Transpl 2016 Nov-Dec;27(6):1265-1269
    Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
    Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare condition most frequently seen in patients with advanced chronic kidney disease. The clinical picture is characterized by painful skin lesions and ulcerations. The underlying pathology is medial calcification and intimal proliferation with microthrombi of small arteries. Read More

    Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis.
    Intern Med 2016;55(22):3315-3320. Epub 2016 Nov 15.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
    Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. Read More

    Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen
    Clin Nephrol 2016 Nov 14. Epub 2016 Nov 14.
    Background: Calciphylaxis in a nondialysis patient is a rare condition and is characterized by calcific deposition in tissue. We present a case of calciphylaxis in a nondialysis patient who was diagnosed by clinical presentation and skin biopsy and was treated with sodium thiosulfate with improvement of skin lesions.

    Case: A 43-year-old female with type 2 diabetes and atrial fibrillation taking oral anticoagulation medication presented with reddish drainage from the right buttock. Read More

    Resolution of Calciphylaxis After Urgent Kidney Transplantation in 3 Patients With End-Stage Kidney Failure.
    Transplant Direct 2016 Nov 25;2(11):e113. Epub 2016 Oct 25.
    Section of Nephrology, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Norway.
    Background: Calcific uremic arteriolopathy (CUA), also referred to as calciphylaxis, is a rare and serious complication of kidney failure with limited treatment options. Kidney transplantation (KTX) restores kidney function and is hence a potential treatment option for CUA. We present 3 patients who had their CUA lesions successfully healed after urgent KTX. Read More

    [Cutaneous manifestations in renal diseases].
    Hautarzt 2016 Dec;67(12):960-969
    Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Read More

    Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis.
    Iran Red Crescent Med J 2016 Aug 15;18(8):e30913. Epub 2016 Jun 15.
    Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Life Science, Tunghai University, Taichung, Taiwan.
    Introduction: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials.

    Case Presentation: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. Read More

    Generalized Weakness in a Transplant Patient: A Case Presentation.
    PM R 2016 Oct 16;8(10):1011-1015. Epub 2016 Apr 16.
    Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA(†).
    Generalized weakness in transplant patients is a major complaint in tertiary rehabilitation hospitals. The diagnosis and management of generalized weakness in this population pose challenges for physicians. We present the case of a transplant patient with generalized weakness who was eventually diagnosed with calciphylaxis using a multidisciplinary diagnostic approach of electrodiagnostics, vascular study, and skin biopsy. Read More

    Calciphylaxis: A Disease of Pannicular Thrombosis.
    Mayo Clin Proc 2016 Oct;91(10):1395-1402
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
    Objective: To identify coagulation risk factors in patients with calciphylaxis and the relationship between anticoagulation use and overall survival.

    Patients And Methods: Study subjects were 101 patients with calciphylaxis seen at Mayo Clinic from 1999 to September 2014. Data including thrombophilia profiles were extracted from the medical records of each patient. Read More

    Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis.
    Mayo Clin Proc 2016 Oct;91(10):1384-1394
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
    Objective: To report on the survival and the associations of treatments upon survival of patients with calciphylaxis seen at a single center.

    Patients And Methods: Using the International Classification of Diseases, Ninth Revision diagnosis code of 275.49 and the keyword "calciphylaxis" in the dismissal narrative, we retrospectively identified 101 patients with calciphylaxis seen at our institution between January 1, 1999, through September 20, 2014, using a predefined, consensus-developed classification scheme. Read More

    Calciphylaxis in peritoneal dialysis patients: a single center cohort study.
    Int J Nephrol Renovasc Dis 2016 19;9:235-241. Epub 2016 Sep 19.
    Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA.
    Background: Calciphylaxis is a rare but devastating condition in end-stage renal disease (ESRD) patients. Most research in the field of calciphylaxis is focused on hemodialysis (HD) patients; however, data on calciphylaxis incidence, risk factors, and mortality in peritoneal dialysis (PD) patients are limited.

    Methods: In this cohort study, we examined data from adult patients who initiated PD for ESRD management at our institute's PD unit from January 2001 to December 2015. Read More

    Plant phosphates, phytate and pathological calcifications in chronic kidney disease.
    Nefrologia 2017 Jan - Feb;37(1):20-28. Epub 2016 Sep 30.
    Laboratorio de Investigación en Litiasis Renal, Instituto de Ciencias de la Salud Investigación (IUNICS-IdISPa), Departamento de Química, Universidad de las Islas Baleares, Palma de Mallorca, Islas Baleares, España.
    Phytate, or myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate (InsP6), is a naturally occurring phosphorus compound that is present in many foods, mainly legumes, whole grains and nuts. Patients with chronic kidney disease (CKD) have cardiovascular disease mortality up to 30times higher than the general population. Vascular calcifications (VCs) directly contribute to overall morbidity and mortality, especially in CKD. Read More

    Bilateral optic neuropathy, acral gangrene and visceral ischaemia as a rare presentation of calciphylaxis: A case report.
    J Pak Med Assoc 2016 Oct;66(10):1324-1326
    Neurology Clinics, Ankara Ataturk Education and Research Hospital, Bilkent, Ankara, Turkey.
    We report a case with calciphylaxis very rarely presenting with bilateral optic neuropathy, acral gangrene and visceral ischaemia. Bilateral papilloedaema was found in a 43 year-old female with chronic renal failure. Acral dry gangrene was observed. Read More

    The efficacy and safety of sevelamer and lanthanum versus calcium-containing and iron-based binders in treating hyperphosphatemia in patients with chronic kidney disease: a systematic review and meta-analysis.
    Nephrol Dial Transplant 2017 Jan;32(1):111-125
    Department of Epidemiology & Biostatistics, Western University, London, ON, Canada.
    Background.: It remains unclear which phosphate binders should be preferred for hyperphosphatemia management in chronic kidney disease (CKD).

    Methods. Read More

    Clinical Application and Pharmacodynamic Monitoring of Apixaban in a Patient with End-Stage Renal Disease Requiring Chronic Hemodialysis.
    Pharmacotherapy 2016 Nov 14;36(11):e166-e171. Epub 2016 Oct 14.
    Department of Pharmacy, Upstate University Hospital, Syracuse, New York.
    Despite prescribing guidance, limited data exist to describe the use of apixaban in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD). Current apixaban dosing recommendations for this patient population are based largely on a single-dose pharmacokinetic study of eight patients. We describe the clinical application and pharmacodynamic monitoring of apixaban in a 62-year-old 156-kg African-American woman with nonvalvular atrial fibrillation and ESRD requiring hemodialysis who developed calciphylaxis while receiving warfarin therapy. Read More

    Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology.
    Dermatology 2016 14;232(5):523-533. Epub 2016 Sep 14.
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists. They share the same clinical patterns: necrotizing livedo, skin infarctions at typical locations and acral gangrene in calciphylaxis. Read More

    Sodium Thiosulfate: Calciphylaxis.
    Hosp Pharm 2015 Nov 24;50(11):975-7. Epub 2015 Nov 24.
    Founder and Contributing Editor , The Formulary, and Editor, Off-Label Drug Facts , e-mail: .
    This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a publication available from Wolters Kluwer Health. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. This new guide to the literature enables the health care professional or clinician to quickly identify published studies on off-label uses and determine if a specific use is rational in a patient care scenario. Read More

    Cardiovascular calcifications in chronic kidney disease: Potential therapeutic implications.
    Nefrologia 2016 Nov - Dec;36(6):597-608. Epub 2016 Aug 30.
    Servicio de Nefrología, Fundació Puigvert, IIB Sant Pau, RedinRen, Barcelona, España.
    Cardiovascular (CV) calcification is a highly prevalent condition at all stages of chronic kidney disease (CKD) and is directly associated with increased CV and global morbidity and mortality. In the first part of this review, we have shown that CV calcifications represent an important part of the CKD-MBD complex and are a superior predictor of clinical outcomes in our patients. However, it is also necessary to demonstrate that CV calcification is a modifiable risk factor including the possibility of decreasing (or at least not aggravating) its progression with iatrogenic manoeuvres. Read More

    Case Report of Calciphylaxis Secondary to Calcium and Vitamin D3 Supplementation.
    J Cutan Med Surg 2017 Mar/Apr;21(2):162-163. Epub 2016 Sep 21.
    1 Department of Dermatology, University College Hospital, Galway, Ireland.
    Background: Calciphylaxis is a rare disorder that is very unusual outside the setting of end-stage kidney disease.

    Case Summary: A 64-year-old woman with normal renal function presented with painful leg ulcers. She had previously received 300 000 IU of vitamin D3 followed by daily calcium and vitamin D3 supplementation. Read More

    Hypothesis: Phytate is an important unrecognised nutrient and potential intravenous drug for preventing vascular calcification.
    Med Hypotheses 2016 Sep 12;94:89-92. Epub 2016 Jul 12.
    Laboratoris Sanifit, Parc Bit, Palma de Mallorca, Spain; Institute of Health Sciences Research, University of Balearic Sciences, Palma de Mallorca, Spain.
    Cardiovascular calcification (CVC) associated with conditions such as ageing, diabetes or renal impairment, results from the deposition of hydroxyapatite in the endothelium or media of blood vessels. Key medical management options are directed towards controlling plasma calcium and phosphate concentrations (e.g. Read More

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