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    1 OF 26

    Clinical course after parathyroidectomy in adults with end-stage renal disease on maintenance dialysis.
    Clin Kidney J 2018 Apr 17;11(2):265-269. Epub 2017 Aug 17.
    Department of Nephrology, Serdang Hospital, Malaysia.
    Background: Parathyroidectomy (PTX) is done in cases of secondary hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy. Despite this widespread practice, clinical outcomes regarding the benefits of this procedure are still lacking. Most studies in the literature have opted to report the laboratory outcome instead. Read More

    A Rare Case of Calciphylaxis in an Orthotopic Liver Transplant Recipient with Acute Kidney Injury.
    Exp Clin Transplant 2018 Apr 9. Epub 2018 Apr 9.
    From the Department of Transplant Nephrology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.
    Calciphylaxis is a rare disease characterized by calcification of small- to medium-sized blood vessels in the dermis and subcutaneous fat, resulting in cutaneous necrosis. Although most commonly shown in patients with end-stage kidney disease, it has also been reported in patients with other diseases, including alcoholic cirrhosis and malignancies. Here, we report an unusual case of calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury. Read More

    Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.
    CEN Case Rep 2018 Mar 28. Epub 2018 Mar 28.
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Calciphylaxis presents with painful purpura and intractable skin ulcers on the trunk and particularly the distal extremities, and it mainly occurs in patients on chronic dialysis. A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years. He developed calciphylaxis of the penis, which was diagnosed from the skin biopsy findings and clinical observation. Read More

    Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series.
    Wounds 2018 Mar;30(3):72-78
    Wayne UNC Health Care's Wound Healing and Hyperbaric Center, Goldsboro, NC.
    Introduction: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase. Read More

    Calcimimetics versus parathyroidectomy: What is preferable?
    Int Urol Nephrol 2018 Mar 12. Epub 2018 Mar 12.
    University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia.
    Secondary hyperparathyroidism (SHPT) is common among patients with end-stage renal disease (ESRD). SHPT is associated with high-turnover bone disease, interstitial and vascular calcifications, cardiovascular morbidity and mortality. The pharmacological management of SHPT has progressed in recent years. Read More

    [Breast calciphylaxis: An uncommon and difficult pathology].
    Presse Med 2018 Mar 9;47(3):288-291. Epub 2018 Mar 9.
    CHRU, hôpital de Hautepierre, pôle de gynécologie et obstétrique, unité de sénologie, avenue Molière, 67200 Strasbourg, France; Université de Strasbourg, IGBMC, institut de génétique et biologie moléculaire et cellulaire, CNRS UMR 7104, Inserm U964, 1, rue Laurent-Fries, 67400 Illkirch-Graffenstaden, France; Centre hospitalier de Sarrebourg, rue des Roses, 57400 Sarrebourg, France.

    Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
    Clin J Am Soc Nephrol 2018 Mar 9. Epub 2018 Mar 9.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California, Irvine, California
    Secondary hyperparathyroidism develops in CKD due to a combination of vitamin D deficiency, hypocalcemia, and hyperphosphatemia, and it exists in nearly all patients at the time of dialysis initiation. There is insufficient data on whether to prefer vitamin D analogs compared with calcimimetics, but the available evidence suggests advantages with combination therapy. Calcium derangements, patient adherence, side effects, and cost limit the use of these agents. Read More

    Calciphylaxis in a Patient With Non-Hodgkin Lymphoma: Case Report and Literature Review.
    J Cutan Med Surg 2018 Feb 1:1203475418761867. Epub 2018 Feb 1.
    1 Dermatology Department, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
    Background: Calciphylaxis is a well-known entity in end-stage kidney disease and after renal transplant. Cases of nonuremic calciphylaxis (NUC) have also been reported, but data on this rare condition are mainly empirical.

    Objective: We discuss a case of NUC secondary to spontaneous tumour lysis syndrome in a patient who had chemotherapy for non-Hodgkin lymphoma and present a review of the literature to better characterize malignancy-associated NUC. Read More

    [Calcific uremic arteriolopathy (calciphylaxis)  : update in 2018].
    Rev Med Suisse 2018 Feb;14(595):426-429
    Service de néphrologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
    Calciphylaxis is a rare disease with a poor prognostic that mostly occurs in patients with renal failure. Diagnosis is difficult and skin biopsy is the gold standard diagnostic procedure, although it may aggravate skin lesions. Identification of the typical cutaneous signs is important to initiate adequate medical care. Read More

    A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh.
    Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):18-23. Epub 2017 Nov 16.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis. Read More

    Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease.
    Am J Case Rep 2018 Feb 1;19:118-122. Epub 2018 Feb 1.
    Department of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, KS, USA.
    BACKGROUND Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function. CASE REPORT We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. Read More

    Sodium thiosulfate mediated cardioprotection against myocardial ischemia-reperfusion injury is defunct in rat heart with co-morbidity of vascular calcification.
    Biochimie 2018 Apr 3;147:80-88. Epub 2018 Feb 3.
    Vascular Biology Lab, SASTRA Deemed University, Thanjavur, 613401, India. Electronic address:
    Sodium thiosulfate (STS) has shown promising effects in amelioration of myocardial ischemia-reperfusion injury (IR) in a rat model and is clinically useful in the treatment of chronic kidney disease (CKD) associated calciphylaxis. As the prevalence of cardiac complications is higher in CKD, we tested the effectiveness of STS in a rat model of adenine-induced vascular calcification and subjected the heart to IR. We observed an increased infarct size (29%) by TTC staining, lactate dehydrogenase (54%) and creatine kinase (32%) release in the coronary perfusate and altered hemodynamics compared to a normal rat treated with STS and subjected to IR. Read More

    SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels.
    J Nephrol 2018 Apr 19;31(2):287-296. Epub 2018 Jan 19.
    Nephrology and Renal Transplantation, Hospital Clínic, Barcelona, Spain.
    Background: Cardiovascular calcification (CVC) is a major concern in hemodialysis (HD) and the loss of endogenous modulators of calcification seems involved in the process. Phytate is an endogenous crystallization inhibitor and its low molecular mass and high water solubility make it potentially dialyzable. SNF472 (the hexasodium salt of phytate) is being developed for the treatment of calciphylaxis and CVC in HD patients. Read More

    Evaluating the validity of subclassifying warfarin-associated nonuremic calciphylaxis: a retrospective cohort study.
    Int J Dermatol 2018 May 16;57(5):572-574. Epub 2018 Jan 16.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Background: Calciphylaxis is a devastating multifactorial disorder of the subcutaneous fat that is known to be associated with hypercoagulability. Recent literature has proposed subclassifying patients with calciphylaxis as having warfarin-associated or warfarin-unassociated disease.

    Aim: We aimed to determine whether patients with warfarin-associated calciphylaxis differ clinically from patients with warfarin-unassociated calciphylaxis. Read More

    [A POEMS syndrome revealed by a blue toe syndrome].
    Rev Med Interne 2018 Feb 26;39(2):127-129. Epub 2017 Dec 26.
    Service de médecine vasculaire, hôpitaux de Brabois, CHRU de Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm UMR-S 1116, université de Lorraine, 54000 Nancy, France.
    Introduction: Arterial and venous thromboses occur in almost one in five patients with POEMS syndrome and usually in macrocirculation.

    Case Report: We report a 67-year-old male with a POEMS syndrome who presented initially with a blue toe syndrome. He complained of Raynaud's syndrome and left foot paresthesia. Read More

    Association Between Hypercoagulable Conditions and Calciphylaxis in Patients With Renal Disease: A Case-Control Study.
    JAMA Dermatol 2018 Feb;154(2):182-187
    Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School, Boston.
    Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis.

    Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD. Read More

    3DTEE imaging of a descending aorta floating thrombus in a patient with calciphylaxis.
    Echocardiography 2018 Jan 11;35(1):132-134. Epub 2017 Dec 11.
    Department of Cardiology, King's College Hospital NHS Foundation Trust, King's College London, London, UK.
    We present a case of a 68-year-old man with calciphylaxis, who was found to have a floating thrombus in the descending aorta on a transesophageal echocardiogram. The use of 3D echocardiography demonstrated nicely the free motion of the thrombus, emerging from an atherosclerotic plaque in the descending aorta. Anticoagulation was started for thromboembolism prevention. Read More

    Patterns of vascular calcification in patients with end-stage renal disease and calcific uremic arteriolopathy.
    Clin Case Rep 2017 Dec 9;5(12):2143-2145. Epub 2017 Oct 9.
    Division of Nephrology, Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFlorida.
    Calcific uremic arteriolopathy or calciphylaxis is a rare and potentially fatal condition, which manifests as skin ischemia and necrosis, usually seen in patients with end-stage renal disease. It is frequently associated with vascular calcification visible on plain radiographs, which can occur in various patterns. Read More

    Clinical Assessment of Warfarin Therapy in Patients with Maintenance Dialysis-Clinical Efficacy, Risks and Development of Calciphylaxis.
    Ann Vasc Dis 2017 Sep;10(3)
    Department of Nephrology and Hypertension, and Blood Purification Center, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
    Recent years, multiple studies regarding clinical efficacy and risks of Warfarin therapy in dialysis patients have been reported, and not a few reports conclude that clinical advantage of Warfarin is questionable in dialysis patients. Conversely, its hemorrhagic risk might be a little more serious in dialysis patients comparing to non-dialysis patients. Basically, it is assumed that long-term administration of Warfarin accelerates the development of vascular athelosclerosis because of the abolished anti-calcification effect of Gla-protein activation by decreased vitamin K activity. Read More

    Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis.
    Am J Nephrol 2017 9;46(5):429-438. Epub 2017 Nov 9.
    Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Background: The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis.

    Methods: Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies directed against BMP effector proteins phosphorylated-SMAD (p-SMAD) 1/5/9, inhibitor of DNA 1 (Id1), inhibitor of DNA 3 (Id3), and Runx2. Read More

    Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair.
    Urology 2018 Feb 26;112:222-224. Epub 2017 Oct 26.
    Thomas Jefferson University School of Medicine, Philadelphia, PA.
    Objective: To present our technique for staged urethroplasty with buccal mucosa graft.

    Methods: The patient presented is a 42-year-old man with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self-intermittent dilation. Read More

    Calciphylaxis with pseudoxanthoma elasticum-like changes: A case series.
    J Cutan Pathol 2018 Feb 12;45(2):118-121. Epub 2017 Dec 12.
    The Ronald O. Perelman Department of Dermatology, Section of Dermatopathology, New York University, New York, New York.
    Background: Calciphylaxis and pseudoxanthoma elasticum (PXE) are rare, clinically distinct disorders that share a common feature of cutaneous calcification and that vary widely in their cutaneous presentation.

    Methods: We conducted a descriptive, retrospective review of biopsy specimens collected over a 2-year period. Only specimens with a histologic and clinical diagnosis of calciphylaxis were included in the review. Read More

    Calciphylaxis after parathyroidectomy.
    Hemodial Int 2017 10;21 Suppl 2:S62-S66
    Methodist Dallas Medical Center and Dallas Nephrology Associates, Dallas, Texas, USA.
    A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. Read More

    Clinical characteristics and risk factors associated with mortality in calcific uremic arteriolopathy.
    Int Urol Nephrol 2017 Dec 20;49(12):2247-2256. Epub 2017 Oct 20.
    Division of Nephrology, Hennepin County Medical Center, Minneapolis, MN, USA.
    Background: Calcific uremic arteriolopathy (CUA) is an often-fatal condition in dialysis patients. The clinical descriptions and treatments of CUA patients have been confined mostly to case reports. We report a comprehensive characterization of CUA and its associated diagnosis, treatment patterns, and outcome. Read More

    Histopathology of Calciphylaxis: Cohort Study With Clinical Correlations.
    Am J Dermatopathol 2017 Nov;39(11):795-802
    *Medical Student, Mayo Medical School, Mayo Clinic, Rochester, MN; †Associate Professor, Department of Dermatology, Mayo Clinic, Rochester, MN; ‡Professor, Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; §Biostatistician, Department of Health Sciences Research, Mayo Clinic, Rochester, MN; and ‖Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.
    Calciphylaxis is a rare, painful, and life-threatening condition with a high mortality rate. Although the etiology of calciphylaxis is not well understood, it has been proposed that calcium deposition within and around subcutaneous vessels restricts blood flow chronically, thereby predisposing the patient to acute pannicular and dermal thrombosis. Given increasing recognition of the role of hypercoagulability in calciphylaxis, this retrospective cohort study sought to evaluate the presence of thromboses and dermal angioplasia in calciphylaxis. Read More

    Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen.
    Clin Nephrol Case Stud 2017 6;5:38-41. Epub 2017 Jul 6.
    Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, and.
    Background: Calciphylaxis in a nondialysis patient is a rare condition and is characterized by calcific deposition in tissue. We present a case of calciphylaxis in a nondialysis patient who was diagnosed by clinical presentation and skin biopsy and was treated with sodium thiosulfate with improvement of skin lesions.

    Case: A 43-year-old female with type 2 diabetes and atrial fibrillation taking oral anticoagulation medication presented with reddish drainage from the right buttock. Read More

    Anterior Ischemic Optic Neuropathy Due to Calciphylaxis.
    J Neuroophthalmol 2018 Mar;38(1):54-56
    Departments of Ophthalmology (MSS, ØKJ), Pathology (EHS) and Dermatology (KMAE), Oslo University Hospital, Oslo, Norway.
    A 72-year-old woman experienced anterior ischemic optic neuropathy in her left eye. The funduscopic and fluorescein angiographic findings were strongly suggestive of giant cell arteritis. Temporal artery biopsy revealed extensive calcification in the vessel wall consistent with calciphylaxis. Read More

    Parathyroidectomy in Hyperparathyroidism-Associated Calciphylaxis in End-Stage Renal Disease Should be Prompt and Radical - a Case Report with Two Original Therapeutic Modifications and Successful Outcome.
    Acta Medica (Hradec Kralove) 2017 ;60(2):85-88
    Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Králové, Czech Republic.
    We present a case of severe calciphylaxis in both thighs and calves in a patient with end-stage renal disease and advanced secondary hyperparathyroidism with successful outcome after modified therapeutic approach. The cause of calciphylaxis is multifactorial. In our case, not only severe hyperparathyroidism and mediocalcinosis, but also medication (warfarin, calcium and active vitamin D) was involved. Read More

    Extraosseous Calcification of the Esophagus: Clinicopathologic Correlates of Esophageal Mucosal Calcinosis.
    ACG Case Rep J 2017 13;4:e108. Epub 2017 Sep 13.
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH.
    Esophageal mucosal calcinosis (EMC) is a rare cause of dysphagia with high morbidity. We present a patient who experienced melena and 3 months of solid and liquid dysphagia along with bilateral lower extremity pain, erythema, and edema later determined to be calcific uremic arteriolopathy (CUA), or calciphylaxis. An esophagogastroduodenoscopy revealed nodularity and linear ulcerations in the upper third of the esophagus. Read More

    Seeing the difference-Painless progressive vision loss in a vasculopath.
    Surv Ophthalmol 2017 Sep 18. Epub 2017 Sep 18.
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia.
    A 78-year-old Caucasian man with significant vascular disease reported sudden onset of worsened vision during a routine wound-care appointment for nonhealing necrotic leg ulcers. He described painless blurring of vision with grey scotomas in his right eye, his only well-seeing eye, after trauma to the left eye as a child. He presented with retinal ischemia, a cotton wool spot, and optic nerve swelling. Read More

    Evaluation of osteopontin expression in chronic wounds: a potential prognostic and therapeutic biomarker.
    J Wound Care 2017 Sep;26(Sup9):S4-S8
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, US.
    Objective: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. Read More

    Sodium Thiosulfate in the Treatment of Lung and Breast Calciphylaxis: CT and Bone Scintigraphy Findings.
    Clin Nucl Med 2017 Nov;42(11):893-895
    From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
    A 19-year-old woman, with normal kidney function, was diagnosed as having visceral calciphylaxis, especially diffuse breast and lung calcification. The calcification findings were clearly shown on CT, and bone scintigraphy revealed diffuse uptake in the thoracic area. Although there was no standard therapeutic approach for this clinical setting, the patient received empiric therapy with sodium thiosulfate. Read More

    Pseudoxanthoma elasticum-like changes in nonuremic calciphylaxis: Case series and brief review of a helpful diagnostic clue.
    J Cutan Pathol 2017 Dec 19;44(12):1064-1069. Epub 2017 Sep 19.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
    Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. Read More

    Direct oral anticoagulant medications in calciphylaxis.
    Int J Dermatol 2017 Oct 30;56(10):1065-1070. Epub 2017 Aug 30.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Background: Recent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis. Our objective is to report the use of oral direct thrombin and factor Xa inhibitors (termed direct oral anticoagulants [DOACs]) in patients with calciphylaxis. Read More

    Calciphylaxis of the Postmenopausal Female Breast: An Uncommonly Encountered Mimic of Carcinoma.
    Case Rep Pathol 2017 9;2017:4541620. Epub 2017 Aug 9.
    Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
    Calciphylaxis is a serious medical condition that is typically associated with end-stage renal disease and presents as the sequelae of calcifications in arterioles with subsequent ischemia of affected tissues. Classically, calciphylaxis produces ulcerated and necrotic skin lesions. These may be biopsied to aid in confirmation of the diagnosis. Read More

    Vasculopathies, cutaneous necrosis and emergency in dermatology.
    G Ital Dermatol Venereol 2017 Dec 28;152(6):615-637. Epub 2017 Jul 28.
    Department of Dermatology, de La Princesa University Hospital, Madrid, Spain.
    Most emergencies in dermatology comprise a variety of entities with a usually benign course. However, vasculopathies and vasculitis are not common, but they could represent respectively 1.9% and 4. Read More

    [Calciphylaxis].
    Medicina (B Aires) 2017 ;77(4):331-333
    Departamento de Ortopedia y Traumatología, Hospital Universitario, Fundación Favaloro, Buenos Aires, Argentina.
    Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. It most frequently compromises patients with terminal chronic renal failure and has a high mortality rate. Biopsy of skin lesions is used as a diagnostic method. Read More

    Calciphylaxis with extensive arterial calcification.
    Clin Case Rep 2017 Aug 3;5(8):1418-1419. Epub 2017 Jul 3.
    Division of Nephrology, Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFlorida.
    Calciphylaxis is a clinical syndrome of arteriolar calcification with resultant tissue necrosis, most commonly seen in patients with end-stage renal disease (ESRD) on dialysis. This condition carries a high mortality rate mainly due to infection. Helpful interventions include adequate dialytic therapy, medical management of hyperparathyroidism, hyperphosphatemia, and intravenous sodium thiosulfate therapy. Read More

    Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases.
    Semin Arthritis Rheum 2017 Dec 17;47(3):451-455. Epub 2017 Jun 17.
    Service de pédiatrie, Hopital de la Mère et de l'Enfant, Limoges, France. Electronic address:
    Introduction: Tumoral calcinosis (TC) is a difficult-to-treat complication that can occur during several diseases such as dermatomyositis or genetic hyperphosphatemia. It is a painful and disabling condition that can lead to local complications including joint mobility reduction, cutaneous ulceration and superinfection. For the largest lesions, the treatment relies essentially on surgery. Read More

    Gastric Pneumatosis from Isolated Gastric Calciphylaxis.
    ACG Case Rep J 2017 19;4:e91. Epub 2017 Jul 19.
    Department of Gastroenterology, University of Cincinnati Medical Center, Cincinnati, OH.
    A 58-year-old man with end-stage renal disease presented with hypotension and emesis, pale conjunctivae, and a distended abdomen. Labs revealed hypercalcemia and leukocytosis. Abdominal imaging showed gastric pneumatosis. Read More

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