1,315 results match your criteria Calciphylaxis


Role of Bisphosphonates in Vascular calcification and Bone Metabolism: A Clinical Summary.

Curr Cardiol Rev 2018 Jun 18. Epub 2018 Jun 18.

Department of Nephrology, Einstein Medical Center, Sidney Kimmel College of Thomas Jefferson University, Philadelphia. United States.

Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process. Read More

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June 2018
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Multifactorial aetiology for non-uremic calciphylaxis: a case report.

J Community Hosp Intern Med Perspect 2018 12;8(3):163-166. Epub 2018 Jun 12.

Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal.

Calciphylaxis is commonly associated with end-stage renal disease patients on haemodialysis. We present a rare case of calciphylaxis in a non-uremic patient. The diagnosis was made clinically and confirmed with skin biopsy showing calcification of the dermal and subcutaneous tissues in the von Kossa stain. Read More

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Bone scintigraphy findings in calciphylaxis.

Radiol Case Rep 2018 Apr 28;13(2):315-319. Epub 2018 Jan 28.

Department of Radiology, Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA, USA.

Calciphylaxis is a poorly understood condition involving vascular calcification and thrombosis that leads to skin necrosis. Unfortunately, a noninvasive definitive test for calciphylaxis does not currently exist, and diagnosis relies on clinical symptoms and risk factors. Imaging can help guide diagnosis of this rare disorder. Read More

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Using Machine Learning Algorithms to Predict Risk for Development of Calciphylaxis in Patients with Chronic Kidney Disease.

AMIA Jt Summits Transl Sci Proc 2018 18;2017:139-146. Epub 2018 May 18.

Marshfield Clinic Research Institute, Marshfield, WI.

Calciphylaxis is a disorder that results in necrotic cutaneous lesions with a high rate of mortality. Due to its rarity and complexity, the risk factors for and the disease mechanism of calciphylaxis are not fully understood. This work focuses on the use of machine learning to both predict disease risk and model the contributing factors learned from an electronic health record data set. Read More

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A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum.

Dermatol Reports 2018 Apr 14;10(1):7445. Epub 2018 May 14.

Department of Pathology, Trakya University Faculty of Medicine, Edirne, Turkey.

The differential diagnosis of chronic ulcers covers a wide range of diseases and poses a diagnostic challenge. Subcutaneous ischemic arteriolosclerosis can lead to local ischaemia and ulceration as a result of arteriolar narrowing and reduction of tissue perfusion. This pathophysiological feature can be seen in eutrophication (nonuremic calciphylaxis) in morbid obesity, hypertensive ischemic leg ulcer (Martorell ulcer) and calciphylaxis in chronic renal insufficiency. Read More

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Questionable specificity of histologic findings in calcific uremic arteriolopathy.

Kidney Int 2018 Jun 6. Epub 2018 Jun 6.

Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:

A variety of criteria exist for histopathologic diagnosis of calciphylaxis, also known as calcific uremic arteriolopathy but data on their specificity are limited. To assess this, histologic findings of 38 skin biopsies performed for a suspicion of calcific uremic arteriolopathy were compared with histologic findings in skin obtained from healthy margins of 43 amputations in patients with end-stage renal disease (ESRD) without evidence of calcific uremic arteriolopathy. Abnormalities in small arteries or arterioles were present in 35% of amputation specimens and 55% of skin biopsies, and among these only thrombosis but not calcification was significantly more prevalent in skin biopsies. Read More

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June 2018
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An Update on Calciphylaxis.

Am J Clin Dermatol 2018 May 28. Epub 2018 May 28.

Department of Dermatology, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo León, Av. Madero y Gonzalitos S/N 64460 Col. Mitras Centro, Monterrey, Mexico.

Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial wall calcification and intimal hyperplasia, is a multifactorial cutaneous vascular disease characterized by chronic, painful, non-healing wounds that occur frequently in patients with chronic kidney disease, predominantly in those with end-stage renal disease. The pathogenesis remains unclear, and the development of calciphylaxis lesions depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. Despite an increase in reports of calciphylaxis in the literature and clinical recognition of demographic characteristics and risk factors associated with calciphylaxis, it remains a poorly understood disease with high morbidity and mortality. Read More

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May 2018
3 Reads

Bilateral breast calciphylaxis in a patient who survived earlier extensive tissue necrosis 5 years previously: A case report.

Int J Surg Case Rep 2018 May 7;48:22-25. Epub 2018 May 7.

Departement of general surgery. Máxima Medisch Centrum, De Run 4600, 5504 DB Veldhoven, The Netherlands. Electronic address:

Introduction: Calciphylaxis is a rare condition including patchy dermal necrosis that mostly affects chronic hemodialysis patients. The syndrome usually heralds impending death although patients may survive following a set of measures including an adapted dialysis regimen. The present case is a unique patient who recovered from an earlier episode of upper leg calciphylaxis 5 years previously but developed fatal bilateral breast necrosis. Read More

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May 2018
2 Reads

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism.

BMC Nephrol 2018 May 15;19(1):113. Epub 2018 May 15.

Department of Nephrology, The Royal Melbourne Hospital, 300 Grattan St, Parkville, Victoria, 3050, Australia.

Background: The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel biomarkers such as calciprotein particles (CPP). CPP are nanoparticles of mineral and protein in the circulation associated with increased vascular calcification in patients with chronic kidney disease. Read More

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May 2018
3 Reads

Penile Calciphylaxis in a Patient with End-stage Renal Disease: A Case Report and Review of the Literature.

Open Med (Wars) 2018 9;13:158-163. Epub 2018 May 9.

Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan.

Penile calciphylaxis is a rare cause of penile gangrene that presents in patients with end-stage renal disease. The rates of comorbidity and mortality of penile calciphylaxis are extremely high. Unlike other penile gangrene, such as Fournier's gangrene, the benefit of aggressive surgical therapy is controversial. Read More

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May 2018
1 Read

Calcific uremic arteriolopathy.

Oxf Med Case Reports 2017 Oct 20;2017(10):omx055. Epub 2017 Oct 20.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.

Calcific uremic arteriolopathy (CUA) or Calciphylaxis is a rare disease typically seen in end stage renal disease patients on dialysis and is associated with high mortality rates, mainly because of sepsis. Medial calcification of the dermal arterioles is the characteristic histologic finding together with vascular thrombosis and ischemic necrosis. CUA involves legs, abdomen and gluteal region in majority of the patients. Read More

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October 2017

Necrosis of the glans penis secondary to calciphylaxis.

Clin Exp Dermatol 2018 May 8. Epub 2018 May 8.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

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Calciphylaxis.

N Engl J Med 2018 May;378(18):1704-1714

From the Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston (S.U.N., R.T.); the Departments of Biomedical Sciences and Medicine, Cedars-Sinai Medical Center, Los Angeles (R.T.); and the Department of Cardiology, RWTH (Rheinisch-Westfälische Technische Hochschule) Aachen University Hospital, Aachen (V.M.B.), and the Department of Cardiology, Rhein-Maas Klinikum, Würselen (V.M.B.) - both in Germany.

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Calciphylaxis In End Stage Liver and Renal Disease Patients Before and After Transplant.

Clin Transplant 2018 Apr 30:e13272. Epub 2018 Apr 30.

University of Chicago Department of Internal Medicine Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, United States of America.

Calciphylaxis is a rare vascular disorder characterized by calcification of arterioles which causes tissue inflammation and necrosis. It is associated with the metabolic disturbances seen in end stage renal disease (ESRD) and has also been described in patients with cirrhosis with preserved kidney function. Characteristic calciphylaxis lesions are black eschars surrounded by retiform purpura, and the gold standard for diagnosis is skin biopsy. Read More

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Maggot therapy for calciphylaxis wound debridement complicated by bleeding.

JAAD Case Rep 2018 May 7;4(4):396-398. Epub 2018 Apr 7.

Yale School of Medicine, New Haven, Connecticut.

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May 2018
1 Read

Clinical course after parathyroidectomy in adults with end-stage renal disease on maintenance dialysis.

Clin Kidney J 2018 Apr 17;11(2):265-269. Epub 2017 Aug 17.

Department of Nephrology, Serdang Hospital, Malaysia.

Background: Parathyroidectomy (PTX) is done in cases of secondary hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy. Despite this widespread practice, clinical outcomes regarding the benefits of this procedure are still lacking. Most studies in the literature have opted to report the laboratory outcome instead. Read More

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April 2018
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A Rare Case of Calciphylaxis in an Orthotopic Liver Transplant Recipient with Acute Kidney Injury.

Exp Clin Transplant 2018 Apr 9. Epub 2018 Apr 9.

From the Department of Transplant Nephrology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Calciphylaxis is a rare disease characterized by calcification of small- to medium-sized blood vessels in the dermis and subcutaneous fat, resulting in cutaneous necrosis. Although most commonly shown in patients with end-stage kidney disease, it has also been reported in patients with other diseases, including alcoholic cirrhosis and malignancies. Here, we report an unusual case of calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury. Read More

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Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.

CEN Case Rep 2018 Mar 28. Epub 2018 Mar 28.

Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Calciphylaxis presents with painful purpura and intractable skin ulcers on the trunk and particularly the distal extremities, and it mainly occurs in patients on chronic dialysis. A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years. He developed calciphylaxis of the penis, which was diagnosed from the skin biopsy findings and clinical observation. Read More

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Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series.

Wounds 2018 Mar;30(3):72-78

Wayne UNC Health Care's Wound Healing and Hyperbaric Center, Goldsboro, NC.

Introduction: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase. Read More

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March 2018
3 Reads

Calcimimetics versus parathyroidectomy: What is preferable?

Authors:
M Rroji G Spasovski

Int Urol Nephrol 2018 Jul 12;50(7):1271-1275. Epub 2018 Mar 12.

University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia.

Secondary hyperparathyroidism (SHPT) is common among patients with end-stage renal disease (ESRD). SHPT is associated with high-turnover bone disease, interstitial and vascular calcifications, cardiovascular morbidity and mortality. The pharmacological management of SHPT has progressed in recent years. Read More

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July 2018
2 Reads

[Breast calciphylaxis: An uncommon and difficult pathology].

Presse Med 2018 Mar 9;47(3):288-291. Epub 2018 Mar 9.

CHRU, hôpital de Hautepierre, pôle de gynécologie et obstétrique, unité de sénologie, avenue Molière, 67200 Strasbourg, France; Université de Strasbourg, IGBMC, institut de génétique et biologie moléculaire et cellulaire, CNRS UMR 7104, Inserm U964, 1, rue Laurent-Fries, 67400 Illkirch-Graffenstaden, France; Centre hospitalier de Sarrebourg, rue des Roses, 57400 Sarrebourg, France.

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March 2018
2 Reads

[Calciphylaxis in hemodialysis patients: 8 cases treated with sodium thiosulfate].

Ann Dermatol Venereol 2018 Apr 8;145(4):288-292. Epub 2018 Mar 8.

Service de dermatologie, hôpital d'instruction des armées Ste-Anne, 83800 Toulon, France. Electronic address:

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April 2018
2 Reads

Calciphylaxis.

J Emerg Med 2018 May 7;54(5):690-691. Epub 2018 Mar 7.

Department of Emergency Medicine, Staten Island University Hospital, Northwell Health, Staten Island, New York.

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Parathyroidectomy in the Management of Secondary Hyperparathyroidism.

Clin J Am Soc Nephrol 2018 Jun 9;13(6):952-961. Epub 2018 Mar 9.

Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California, Irvine, California

Secondary hyperparathyroidism develops in CKD due to a combination of vitamin D deficiency, hypocalcemia, and hyperphosphatemia, and it exists in nearly all patients at the time of dialysis initiation. There is insufficient data on whether to prefer vitamin D analogs compared with calcimimetics, but the available evidence suggests advantages with combination therapy. Calcium derangements, patient adherence, side effects, and cost limit the use of these agents. Read More

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June 2018
2 Reads

Calciphylaxis in a Patient With Non-Hodgkin Lymphoma: Case Report and Literature Review.

J Cutan Med Surg 2018 Feb 1:1203475418761867. Epub 2018 Feb 1.

1 Dermatology Department, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.

Background: Calciphylaxis is a well-known entity in end-stage kidney disease and after renal transplant. Cases of nonuremic calciphylaxis (NUC) have also been reported, but data on this rare condition are mainly empirical.

Objective: We discuss a case of NUC secondary to spontaneous tumour lysis syndrome in a patient who had chemotherapy for non-Hodgkin lymphoma and present a review of the literature to better characterize malignancy-associated NUC. Read More

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February 2018
3 Reads

[Calcific uremic arteriolopathy (calciphylaxis)  : update in 2018].

Rev Med Suisse 2018 Feb;14(595):426-429

Service de néphrologie, Département des spécialités de médecine, HUG, 1211 Genève 14.

Calciphylaxis is a rare disease with a poor prognostic that mostly occurs in patients with renal failure. Diagnosis is difficult and skin biopsy is the gold standard diagnostic procedure, although it may aggravate skin lesions. Identification of the typical cutaneous signs is important to initiate adequate medical care. Read More

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February 2018
1 Read

A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh.

Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):18-23. Epub 2017 Nov 16.

Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis. Read More

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November 2017
5 Reads

Rheopheresis for Adjuvant Treatment in Resistant Calciphylaxis.

Ther Apher Dial 2018 Feb 11. Epub 2018 Feb 11.

Department of Nephrology, CHU Lille, France.

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February 2018
11 Reads

Pancreatitis associated with calciphylaxis successfully treated with sodium thiosulfate.

JAAD Case Rep 2018 Mar 16;4(2):159-161. Epub 2018 Jan 16.

Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.

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Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease.

Am J Case Rep 2018 Feb 1;19:118-122. Epub 2018 Feb 1.

Department of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, KS, USA.

BACKGROUND Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function. CASE REPORT We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. Read More

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February 2018

Sodium thiosulfate mediated cardioprotection against myocardial ischemia-reperfusion injury is defunct in rat heart with co-morbidity of vascular calcification.

Biochimie 2018 Apr 3;147:80-88. Epub 2018 Feb 3.

Vascular Biology Lab, SASTRA Deemed University, Thanjavur, 613401, India. Electronic address:

Sodium thiosulfate (STS) has shown promising effects in amelioration of myocardial ischemia-reperfusion injury (IR) in a rat model and is clinically useful in the treatment of chronic kidney disease (CKD) associated calciphylaxis. As the prevalence of cardiac complications is higher in CKD, we tested the effectiveness of STS in a rat model of adenine-induced vascular calcification and subjected the heart to IR. We observed an increased infarct size (29%) by TTC staining, lactate dehydrogenase (54%) and creatine kinase (32%) release in the coronary perfusate and altered hemodynamics compared to a normal rat treated with STS and subjected to IR. Read More

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April 2018
2 Reads

SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels.

J Nephrol 2018 Apr 19;31(2):287-296. Epub 2018 Jan 19.

Nephrology and Renal Transplantation, Hospital Clínic, Barcelona, Spain.

Background: Cardiovascular calcification (CVC) is a major concern in hemodialysis (HD) and the loss of endogenous modulators of calcification seems involved in the process. Phytate is an endogenous crystallization inhibitor and its low molecular mass and high water solubility make it potentially dialyzable. SNF472 (the hexasodium salt of phytate) is being developed for the treatment of calciphylaxis and CVC in HD patients. Read More

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April 2018
1 Read

Evaluating the validity of subclassifying warfarin-associated nonuremic calciphylaxis: a retrospective cohort study.

Int J Dermatol 2018 May 16;57(5):572-574. Epub 2018 Jan 16.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: Calciphylaxis is a devastating multifactorial disorder of the subcutaneous fat that is known to be associated with hypercoagulability. Recent literature has proposed subclassifying patients with calciphylaxis as having warfarin-associated or warfarin-unassociated disease.

Aim: We aimed to determine whether patients with warfarin-associated calciphylaxis differ clinically from patients with warfarin-unassociated calciphylaxis. Read More

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May 2018
2 Reads

[A POEMS syndrome revealed by a blue toe syndrome].

Rev Med Interne 2018 Feb 26;39(2):127-129. Epub 2017 Dec 26.

Service de médecine vasculaire, hôpitaux de Brabois, CHRU de Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm UMR-S 1116, université de Lorraine, 54000 Nancy, France.

Introduction: Arterial and venous thromboses occur in almost one in five patients with POEMS syndrome and usually in macrocirculation.

Case Report: We report a 67-year-old male with a POEMS syndrome who presented initially with a blue toe syndrome. He complained of Raynaud's syndrome and left foot paresthesia. Read More

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February 2018
2 Reads

Association Between Hypercoagulable Conditions and Calciphylaxis in Patients With Renal Disease: A Case-Control Study.

JAMA Dermatol 2018 Feb;154(2):182-187

Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School, Boston.

Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis.

Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD. Read More

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February 2018
7 Reads

3DTEE imaging of a descending aorta floating thrombus in a patient with calciphylaxis.

Echocardiography 2018 Jan 11;35(1):132-134. Epub 2017 Dec 11.

Department of Cardiology, King's College Hospital NHS Foundation Trust, King's College London, London, UK.

We present a case of a 68-year-old man with calciphylaxis, who was found to have a floating thrombus in the descending aorta on a transesophageal echocardiogram. The use of 3D echocardiography demonstrated nicely the free motion of the thrombus, emerging from an atherosclerotic plaque in the descending aorta. Anticoagulation was started for thromboembolism prevention. Read More

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January 2018
3 Reads

Patterns of vascular calcification in patients with end-stage renal disease and calcific uremic arteriolopathy.

Clin Case Rep 2017 Dec 9;5(12):2143-2145. Epub 2017 Oct 9.

Division of Nephrology, Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFlorida.

Calcific uremic arteriolopathy or calciphylaxis is a rare and potentially fatal condition, which manifests as skin ischemia and necrosis, usually seen in patients with end-stage renal disease. It is frequently associated with vascular calcification visible on plain radiographs, which can occur in various patterns. Read More

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December 2017
9 Reads

Calciphylaxis: Overview for the vascular nurse.

Authors:
Anne M Foley

J Vasc Nurs 2017 12;35(4):224-229

Department of Vascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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December 2017
2 Reads

Clinical Assessment of Warfarin Therapy in Patients with Maintenance Dialysis-Clinical Efficacy, Risks and Development of Calciphylaxis.

Authors:
Hajime Hasegawa

Ann Vasc Dis 2017 Sep;10(3)

Department of Nephrology and Hypertension, and Blood Purification Center, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.

Recent years, multiple studies regarding clinical efficacy and risks of Warfarin therapy in dialysis patients have been reported, and not a few reports conclude that clinical advantage of Warfarin is questionable in dialysis patients. Conversely, its hemorrhagic risk might be a little more serious in dialysis patients comparing to non-dialysis patients. Basically, it is assumed that long-term administration of Warfarin accelerates the development of vascular athelosclerosis because of the abolished anti-calcification effect of Gla-protein activation by decreased vitamin K activity. Read More

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September 2017
1 Read

Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis.

Am J Nephrol 2017 9;46(5):429-438. Epub 2017 Nov 9.

Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis.

Methods: Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies directed against BMP effector proteins phosphorylated-SMAD (p-SMAD) 1/5/9, inhibitor of DNA 1 (Id1), inhibitor of DNA 3 (Id3), and Runx2. Read More

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November 2017
6 Reads

Calciphylaxis: Another Piece of the Puzzle.

Am J Nephrol 2017 9;46(5):427-428. Epub 2017 Nov 9.

Department of Renal Medicine, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre, Salford, United Kingdom.

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November 2017
5 Reads

Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair.

Urology 2018 Feb 26;112:222-224. Epub 2017 Oct 26.

Thomas Jefferson University School of Medicine, Philadelphia, PA.

Objective: To present our technique for staged urethroplasty with buccal mucosa graft.

Methods: The patient presented is a 42-year-old man with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self-intermittent dilation. Read More

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February 2018
2 Reads

Calciphylaxis with pseudoxanthoma elasticum-like changes: A case series.

J Cutan Pathol 2018 Feb 12;45(2):118-121. Epub 2017 Dec 12.

The Ronald O. Perelman Department of Dermatology, Section of Dermatopathology, New York University, New York, New York.

Background: Calciphylaxis and pseudoxanthoma elasticum (PXE) are rare, clinically distinct disorders that share a common feature of cutaneous calcification and that vary widely in their cutaneous presentation.

Methods: We conducted a descriptive, retrospective review of biopsy specimens collected over a 2-year period. Only specimens with a histologic and clinical diagnosis of calciphylaxis were included in the review. Read More

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February 2018
7 Reads

Calciphylaxis after parathyroidectomy.

Hemodial Int 2017 10;21 Suppl 2:S62-S66

Methodist Dallas Medical Center and Dallas Nephrology Associates, Dallas, Texas, USA.

A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. Read More

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October 2017
5 Reads

Clinical characteristics and risk factors associated with mortality in calcific uremic arteriolopathy.

Int Urol Nephrol 2017 Dec 20;49(12):2247-2256. Epub 2017 Oct 20.

Division of Nephrology, Hennepin County Medical Center, Minneapolis, MN, USA.

Background: Calcific uremic arteriolopathy (CUA) is an often-fatal condition in dialysis patients. The clinical descriptions and treatments of CUA patients have been confined mostly to case reports. We report a comprehensive characterization of CUA and its associated diagnosis, treatment patterns, and outcome. Read More

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December 2017
1 Read

Histopathology of Calciphylaxis: Cohort Study With Clinical Correlations.

Am J Dermatopathol 2017 Nov;39(11):795-802

*Medical Student, Mayo Medical School, Mayo Clinic, Rochester, MN; †Associate Professor, Department of Dermatology, Mayo Clinic, Rochester, MN; ‡Professor, Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; §Biostatistician, Department of Health Sciences Research, Mayo Clinic, Rochester, MN; and ‖Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.

Calciphylaxis is a rare, painful, and life-threatening condition with a high mortality rate. Although the etiology of calciphylaxis is not well understood, it has been proposed that calcium deposition within and around subcutaneous vessels restricts blood flow chronically, thereby predisposing the patient to acute pannicular and dermal thrombosis. Given increasing recognition of the role of hypercoagulability in calciphylaxis, this retrospective cohort study sought to evaluate the presence of thromboses and dermal angioplasia in calciphylaxis. Read More

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November 2017
3 Reads

Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen.

Clin Nephrol Case Stud 2017 6;5:38-41. Epub 2017 Jul 6.

Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, and.

Background: Calciphylaxis in a nondialysis patient is a rare condition and is characterized by calcific deposition in tissue. We present a case of calciphylaxis in a nondialysis patient who was diagnosed by clinical presentation and skin biopsy and was treated with sodium thiosulfate with improvement of skin lesions.

Case: A 43-year-old female with type 2 diabetes and atrial fibrillation taking oral anticoagulation medication presented with reddish drainage from the right buttock. Read More

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July 2017
2 Reads

Anterior Ischemic Optic Neuropathy Due to Calciphylaxis.

J Neuroophthalmol 2018 Mar;38(1):54-56

Departments of Ophthalmology (MSS, ØKJ), Pathology (EHS) and Dermatology (KMAE), Oslo University Hospital, Oslo, Norway.

A 72-year-old woman experienced anterior ischemic optic neuropathy in her left eye. The funduscopic and fluorescein angiographic findings were strongly suggestive of giant cell arteritis. Temporal artery biopsy revealed extensive calcification in the vessel wall consistent with calciphylaxis. Read More

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March 2018
2 Reads