1,365 results match your criteria Calciphylaxis
Cureus 2018 Sep 19;10(9):e3334. Epub 2018 Sep 19.
Internal Medicine, King Edward Medical University, Mayo Hospital, Lahore, PAK.
Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare complication of chronic kidney disease (CKD). Its incidence is increasing due to a better understanding and diagnosis by physicians. Calciphylaxis is a fatal complication of many metabolic disorders. Read More
Inflamm Res 2018 Nov 19. Epub 2018 Nov 19.
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico -Piazza G. Cesare, 11, 70124, Bari, Italy.
Hans Selye was an endocrinologist, a pioneer of research on biological stress in human individuals and groups. His most important scientific contributions include in 1936 the evidence that the pituitary-adrenal-thymus axis was activated by various nocuous stimuli, which led to the involution of the thymus and of the lymphoid organs; in 1946, the theory of general adaptation syndrome (GAS), pointing out that this is a general reaction that leads to resistance of the organism to various insults. This review article is focused on the general interest of Selye on the important role played by mast cells in different pathological conditions and in particular in calciphylaxis and calcergy, summarized in a classic book, which is a lasting contribution on the subject. Read More
Case Rep Urol 2018 18;2018:9603680. Epub 2018 Oct 18.
Department of Urology, Aladan Hospital, Kuwait.
Calciphylaxis or calcific uremic arteriolopathy (CUA) is a potentially life-threatening vasculopathy involving the skin and subcutaneous tissues. It is usually associated with chronic kidney disease (CKD) and rarely with acute renal failure or predialysis patients. The clinical diagnosis of calcific uremic arteriolopathy relies on high index of suspicion. Read More
Nefrologia 2018 Nov - Dec;38(6):579-586. Epub 2018 Nov 8.
Servicio de Nefrología y Trasplante Renal, Hospital Clínic, Barcelona, España. Electronic address:
Calciphylaxis, also known as calcific uraemic arteriolopathy, is a rare syndrome that typically causes skin necrosis and usually affects dialysis patients. Its pathogenesis is multifactorial and is the consequence of many factors causing ectopic calcifications in patients with chronic kidney disease, such as calcium-phosphate metabolism disorders, hyper- or hypo-parathyroidism, diabetes, obesity, systemic inflammation and the use of vitamin K antagonists, among others. From a clinical point of view, calciphylaxis may progress from painful purpura to extensive areas of skin necrosis that can potentially lead to superinfection and the death of the patient due to sepsis. Read More
Nephrol Ther 2018 Nov 29;14(6):439-445. Epub 2018 Jun 29.
Service de néphrologie-hémodialyse et transplantation rénale, université Cadi Ayyad, CHU Mohammed VI, BP 2360 Principal, avenue Ibn Sina, Marrakech, Maroc.
Calcific uremic arteriolopathy, also called calciphylaxis, is a rare and severe disorder that presents with skin ischemia and necrosis, sometimes it presents with systemic necrosis, the process is secondary to the obliteration of the arterioles first by sub-intimal calcium deposits and then by thrombosis. These lesions can often lead to death due to infectious complications and comorbidities such as diabetes, obesity, arteritis, diffuse vascular calcifications, heart disease and undernutrition. The diagnosis is suggested by the characteristic ischemic skin lesions and their distribution, often bilateral and painful, associeted with calcific uremic arteriolopathy risk factors (phosphocalcic abnormalities, anti-vitamin K). Read More
J Pain Symptom Manage 2018 Nov 3. Epub 2018 Nov 3.
Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Palliative and Advanced Illness Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Wound Ostomy Continence Nurs 2018 Nov/Dec;45(6):536-539
Jacqueline M. Zillioux, MD, Department of Urology, University of Virginia, Charlottesville. Alexander Geisenhoff, BS, School of Medicine, Rush University, Chicago, Illinois. Mikel Gray, PhD, Department of Urology, University of Virginia, Charlottesville.
Background: Calciphylaxis, also called calcific uremic arteriolopathy, is a highly morbid syndrome characterized by calcium deposition and occlusion of small arterial vessels of the dermis and subdermal adipose tissue, leading to necrosis and gangrene. Penile involvement is rare and its management presents considerable challenges.
Case: We review the case of a 47-year-old man with end-stage renal disease managed with hemodialysis, diabetes mellitus, and urinary incontinence who presented with a painful necrotic lesion on his glans penis, and the second and third toes of his right foot. Read More
Int Wound J 2018 Nov 4. Epub 2018 Nov 4.
Department of Orthopaedics, Geisinger Medical Center, Danville, Pennsylvania.
Calciphylaxis is a rare and potentially fatal disease that affects the subcutaneous layer of the skin. It is a calcific vasculopathy induced by a systemic process that causes occlusion of small blood vessels. The mortality rate for individuals diagnosed with calciphylaxis is estimated between 52% and 81% with sepsis being the leading cause of death. Read More
Nephrol Ther 2018 Dec 29;14(7):548-553. Epub 2018 Oct 29.
Service de néphrologie, groupe hospitalier La Pitié-Salpêtrière, 75013 Paris, France. Electronic address:
Background: Calciphylaxis or calcific uremic arteriolopathy (CUA) is a cutaneous disease with ulcerations secondary to calcification of cutaneous and subcutaneous small arteries and arterioles. It is a rare but severe disease with significant morbidity and mortality affecting 1 to 4% of dialysis patients. The circumstances of occurrence are multiple. Read More
BMJ Case Rep 2018 Oct 24;2018. Epub 2018 Oct 24.
Medicine; Endocrinology, Diabetes and Nutrition, University of Maryland Medical Center, Baltimore, Maryland, USA.
Calciphylaxis is a rare and life-threatening disease characterized by cutaneous arteriolar stenosis and vascular thrombosis leading to skin ischaemia and necrosis. While calciphylaxis occurs mostly in patients with end-stage renal disease, the disorder has been described in patients with normal renal function, namely non-uraemic calciphylaxis (NUC). A 41-year-old African-American woman presented with a painful ulcerative rash on her thighs and right buttock 2 months after undergoing an orthotopic liver transplantation. Read More
Circulation 2018 Oct;138(15):1530-1533
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston (S.U.N., R.T.).
Burns 2018 Oct 12. Epub 2018 Oct 12.
Burn Center, US Army Institute of Surgical Research, Fort Sam Houston, TX, United States; Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address:
Calciphylaxis is a rare, necrotizing skin disorder usually associated with kidney disease, but also caused by many other systemic illnesses. This disease is associated with mortality rates as high as 80% at 1year. We present the demographic and clinical data of nine patients with calciphylaxis treated at our burn center over a 10year period. Read More
Rev Clin Esp 2018 Oct 9. Epub 2018 Oct 9.
Servicio de Dermatología, Complejo Hospitalario de Toledo, Toledo, España.
QJM 2018 Oct 10. Epub 2018 Oct 10.
Department of Internal Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA.
Calciphylaxis is a disease of significant morbidity and mortality, predominantly affecting dialysis patients. The term 'calciphylaxis' was coined by Seyle et al in 1961 to describe calcium deposition in the skin and subcutaneous soft tissue of uremic rats in response to 'triggers' (e.g. Read More
Clin Kidney J 2018 Oct 9;11(5):704-709. Epub 2018 Mar 9.
Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
Background: Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare but life-threatening condition predominately occurring in patients with end-stage renal disease on dialysis. In the absence of randomized clinical trials to guide management, clinicians must rely on observational data. We have previously reported the outcomes of our multi-intervention management in seven patients and now present a larger series of patients with extended follow-up. Read More
J Cutan Pathol 2018 Oct 2. Epub 2018 Oct 2.
Massachusetts General Hospital, Dermatopathology Unit, Department of Pathology, Boston, Massachusetts.
Background: Calciphylaxis is a rare, painful, and debilitating disorder of vascular calcification and skin necrosis that typically affects patients with advanced kidney disease. During our routine pathology practice, we noted several missed diagnoses on calciphylaxis consultation cases originating from outside institutions and sought to explore factors associated with false-negative pathologic diagnosis of calciphylaxis.
Methods: The pathology database of a large tertiary academic medical center was retrospectively searched for "calciphylaxis" in inside reports on outside surgical consultation cases between 2007 and 2017. Read More
Br J Clin Pharmacol 2018 Dec 3;84(12):2867-2876. Epub 2018 Oct 3.
Laboratoris Sanifit, Palma, Spain.
Aims: SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients.
Methods: This is a first-time-in-human, double-blind, randomized, placebo-controlled Phase I study to assess the safety, tolerability and PK of SNF472 after ascending single IV doses in HV and a single IV dose in HD patients. Read More
Retin Cases Brief Rep 2018 Fall;12(4):331-335
Vitreous Retina Macula Consultants of New York, New York.
Purpose: To report the posterior segment and retinal vascular manifestations of calcific uremic arteriolopathy (calciphylaxis). Clinical findings are correlated with multimodal imaging results.
Methods: Observational case report. Read More
J Clin Rheumatol 2018 Sep 27. Epub 2018 Sep 27.
From the American University of the Caribbean, Coral Gables, FL.
J Wound Ostomy Continence Nurs 2018 Nov/Dec;45(6):532-535
Richard Masoetsa, MPod, Podiatry, Dasman Diabetes Institution, Dasman, Kuwait. Ala A'Groof, MD, FRCSC, Vascular Surgery, Dasman Diabetes Institution, Dasman, Kuwait. Madan Kapoor, DM (Nephro); FRCP (EDIN), Nephrology, Dasman Diabetes Institution, Dasman, Kuwait. Grace Messenger, MRes, Podiatry, Dasman Diabetes Institution, Dasman, Kuwait. Imtiaz Hussain, BSc Honours, Podiatry, Dasman Diabetes Institution, Dasman, Kuwait.
Background: Calciphylaxis is a potentially life-threatening condition involving painful necrotic skin ulcerations, especially of the lower extremities. It is generally associated with chronic kidney failure but may be seen in nonuremic cases.
Case Report: We report a case of calciphylaxis in a 60-year-old man with diabetes on dialysis for end-stage renal disease and known to have other typical combination of risk factors associated with calciphylaxis syndrome. Read More
Skinmed 2018 1;16(4):235-237. Epub 2018 Jul 1.
From the Department of Dermatology and Venereology, Centro Hospitalar São João, EPE, Porto, Portugal.
Calciphylaxis is a rare and severe syndrome of vascular calcification with unclear pathogenesis. This disease mainly affects patients with end-stage renal disease; however, it also has been described in nonuremic patients. We report four cases of nonuremic calciphylaxis (NUC) with ulcerated lesions associated with autoimmune disease. Read More
Mayo Clin Proc 2018 Sep;93(9):1164-1166
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address:
Thromb J 2018 29;16:23. Epub 2018 Aug 29.
St John Providence-Providence Park Hospitals, 19001 W. 9 Mile Rd, Southfield, MI 48075 USA.
Background: Anticoagulation therapy for mechanical prosthetic valves is limited to vitamin K antagonists, unfractionated heparin and low-molecular-weight-heparin. Other forms of anticoagulation are either contraindicated or have not been well studied. Hence, anticoagulation for preexisting mechanical valves is controversial if vitamin K antagonists are contraindicated. Read More
Am J Nephrol 2018 3;48(3):168-171. Epub 2018 Sep 3.
Department of Dermatology, Boston, Massachusetts, USA.
Calciphylaxis is a disease of dermal arteriolar calcification that results in necrosis. It commonly occurs in individuals with end-stage renal disease (ESRD) on hemodialysis and is associated with a high morbidity and mortality. Warfarin use is an identified risk factor. Read More
Am J Nephrol 2018 3;48(3):165-167. Epub 2018 Sep 3.
CNR-IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases, Reggio Calabria, Italy.
Rom J Morphol Embryol 2018 ;59(2):591-594
Department of Internal Medicine and Rheumatology, "Dr. Ion Cantacuzino" Hospital, Bucharest, Romania;
Calciphylaxis is a condition with unclear etiopathogeny with vascular calcifications and thrombotic occlusion that lead to necrotic lesions. It is usually described in patients with end-stage renal disease (ESRD), but also in other conditions. The mortality rate is high, due to sepsis and internal organ failure. Read More
J Am Coll Cardiol 2018 Oct 27;72(18):2152-2163. Epub 2018 Aug 27.
Mount Sinai Heart and Icahn School of Medicine at Mount Sinai, New York, New York.
Background: Critical limb ischemia (CLI) is the most serious complication of peripheral artery disease (PAD).
Objectives: The purpose of this study was to characterize pathology of PAD in below- and above-knee amputation specimens in patients presenting with CLI.
Methods: Peripheral arteries from 95 patients (121 amputation specimens) were examined; 75 patients had presented with CLI, and the remaining 20 had amputations performed for other reasons. Read More
Clin Case Rep 2018 Aug 25;6(8):1641-1642. Epub 2018 Jun 25.
Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville FL USA.
Calciphylaxis or calcific uremic arteriolopathy is a rare and serious disorder typically seen in patients with end-stage renal disease that manifests as skin ischemia and necrosis and histologically characterized by calcification of dermal arterioles. Penis is a rare site of involvement and biopsy is not typically recommended, making the diagnosis clinico-radiologic. Read More
Case Rep Transplant 2018 24;2018:2182083. Epub 2018 Jul 24.
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Hypocalcemia is a frequent complication of parathyroidectomy for secondary/tertiary hyperparathyroidism. In patients with a history of prior Roux-en-Y gastric bypass (RYGBP), changes in nutritional absorption make management of hypocalcemia after parathyroidectomy difficult.
Case Report: A 41-old-year morbidly obese female with c-peptide negative diabetes mellitus and renal failure had RYGBP. Read More
Clin Kidney J 2018 Aug 10;11(4):528-529. Epub 2017 Nov 10.
Canberra Hospital Renal Unit, Garran, ACT, Australia.
Calciphylaxis has high mortality. Vitamin K deficiency is common in haemodialysis patients and may be a trigger for calciphylaxis due to its role in activating matrix Gla protein (a tissue inhibitor of calcification). We report the case of a 43-year-old female haemodialysis patient who developed calciphylaxis. Read More
Dtsch Med Wochenschr 2018 Aug 7;143(16):1155-1156. Epub 2018 Aug 7.
Klinik für Innere Medizin und Nephrologie, Universitätsklinikum Marburg.
Mayo Clin Proc 2018 Sep 27;93(9):1202-1212. Epub 2018 Jul 27.
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA. Electronic address:
Objective: To define concomitant risk factors, treatment, and outcomes for patients with nonnephrogenic calciphylaxis (NNC).
Patients And Methods: A retrospective review of Massachusetts General Hospital (MGH) medical records (January 1, 2014, through February 29, 2016) and a systematic literature review of PubMed, Google Scholar, EMBASE, MEDLINE, and CENTRAL (August 1, 1970, through July 31, 2016) were performed. Demographic characteristics and concomitant features were summarized and compared between patients with different lesion characteristics. Read More
N Engl J Med 2018 07;379(4):398-9
Hospital Virgen de Valme, Seville, Spain
N Engl J Med 2018 07;379(4):398
Northern Hospital, Epping, VIC, Australia
N Engl J Med 2018 07;379(4):398
Centre Hospitalier Régional Universitaire de Lille, Lille, France
N Engl J Med 2018 07;379(4):397-8
Mayo Clinic, Rochester, MN
N Engl J Med 2018 07;379(4):399-400
Rhein-Maas Klinikum, Würselen, Germany
Kidney Int 2018 Aug;94(2):244-246
Department of Pathology, Division of Dermatopathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare disorder that predominantly afflicts patients with end-stage renal disease. In this issue of Kidney International, a report describing histologic features of calciphylaxis questions the specificity of histologic findings typically considered to be characteristic of calciphylaxis. Validated diagnostic criteria are much needed for the clinical care and the investigational studies of patients with calciphylaxis. Read More
Intern Med J 2018 Jul 10. Epub 2018 Jul 10.
Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Victoria.
Background: Secondary hyperparathyroidism (SHPT) in chronic kidney disease is associated with cardiovascular and bone pathology. Measures to achieve parathyroid hormone (PTH) target values and control biochemical abnormalities associated with SHPT require complex therapies, and severe SHPT often requires parathyroidectomy or the calcimimetic cinacalcet. In Australia, cinacalcet was publicly funded for dialysis patients from 2009 to 2015 when funding was withdrawn following publication of the EVOLVE study, which resulted in most patients on cinacalcet ceasing therapy. Read More
J Dtsch Dermatol Ges 2018 Jul;16(7):873-890
Department of Dermatology, Venereology and Allergology, University Medical Center Bochum, Bochum, Germany.
Successful management of patients with leg ulcers requires identification of the underlying etiology, with subsequent initiation of causal treatment, if feasible. Supplementary measures of first choice include stage-adjusted wound treatment, usually combined with compression therapy. The significance of systemic drugs has been the subject of controversial debate, depending on the underlying cause of the condition. Read More
Am J Case Rep 2018 Jul 9;19:804-807. Epub 2018 Jul 9.
Department of Internal Medicine, University of Nevada, School of Medicine, Reno, NV, USA.
BACKGROUND Calciphylaxis is a rare cutaneous disease, also known as calcific uremic arteriolopathy, that occurs most frequently in patients with advanced chronic kidney disease and on long-term hemodialysis. CASE REPORT We describe the case of a 61-year-old female patient with worsening chronic kidney disease not on dialysis therapy, who presented with severe progressive calciphylaxis on both lower limbs. CONCLUSIONS Calcific uremic arteriolopathy is a rare fatal condition that requires prompt diagnosis and treatment. Read More
Medicine (Baltimore) 2018 Jul;97(27):e11300
University of Medicine and Pharmacy Grigore T. Popa Iasi.
Rationale: Though to be rare, calcific uremic arteriolophathy (CUA) is an ectopic calcification entity causing pain and disabilities in patients with chronic renal insufficiency, thus increasing the morbidity and mortality.
Patient Concern: We report a case of four years old boy admitted with acute respiratory failure. Physical examination revealed: irritability, purple subcutaneous hard nodules, tachypnea, dry spasmodic cough, respiratory rate 45/min, heart rate 110/min, blood pressure 100/60 mmHg, with normal heart sounds, no murmurs, hepatomegaly with hepato-jugular reflux. Read More
JAAPA 2018 Jul;31(7):28-30
At the Mayo Clinic in Rochester, Minn., Amber Hesse practices in the Division of Hematology and Andrew Herber and Mike Breunig practice in the Division of Hospital Internal Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Calciphylaxis is a rare disease that typically presents in patients with end-stage renal disease on dialysis or those who have received a renal transplant. Nonuremic calciphylaxis leads to ischemia and subsequent necrosis of subcutaneous tissue. Diseases associated with nonuremic calciphylaxis include primary hyperparathyroidism, connective tissue disease, malignancy, and alcoholic liver disease. Read More
JAMA Dermatol 2018 Aug;154(8):970-971
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
JAMA Dermatol 2018 Aug;154(8):970
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
J Vasc Surg Cases Innov Tech 2018 Jun 27;4(2):133-135. Epub 2018 Apr 27.
Division of Vascular Surgery, Henry Ford Hospital, Detroit, Mich.
Reports of calciphylaxis or calcific uremic arteriolopathy associated with acral and gastrointestinal involvement are rare. We describe a 36-year-old white woman with end-stage renal disease on hemodialysis after failed kidney and pancreas transplantation who developed dry gangrene of bilateral digits, osteomyelitis, and small bowel ischemia within several months of each presentation. She had multiple débridements of a septic right ankle. Read More
An Bras Dermatol 2018 Jun;93(3):397-404
Dermatology Department, University Hospital "Dr. José Eleuterio González", Nuevo León, México, México.
Purpura is defined as a visible hemorrhage in the skin or mucosa, which is not evanescent upon pressure. Proper classification allows a better patient approach due to its multiple diagnoses. Purpuras can be categorized by size, morphology, and other characteristics. Read More
Curr Cardiol Rev 2018 ;14(3):192-199
Department of Nephrology, Einstein Medical Center, Sidney Kimmel College of Thomas Jefferson University, Philadelphia, PA, United States.
Background: Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process. Read More
J Community Hosp Intern Med Perspect 2018 12;8(3):163-166. Epub 2018 Jun 12.
Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal.
Calciphylaxis is commonly associated with end-stage renal disease patients on haemodialysis. We present a rare case of calciphylaxis in a non-uremic patient. The diagnosis was made clinically and confirmed with skin biopsy showing calcification of the dermal and subcutaneous tissues in the von Kossa stain. Read More