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    Calciphylaxis on bone scan: correlation between molecular and cross-sectional findings.
    Radiol Case Rep 2017 Mar 24;12(1):175-178. Epub 2016 Dec 24.
    Department of Radiology, MSC 10-5530, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.
    Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity with the classic clinical presentation and imaging features of this rare entity may help its early identification and treatment. Read More

    Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy.
    S Afr Med J 2017 Jan 30;107(2):140-144. Epub 2017 Jan 30.
    Division of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
    Background: Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage renal disease (ESRD) on haemodialysis, but may rarely occur in the absence of ESRD in conditions such as primary hyperparathyroidism, malignancy, alcoholic liver disease and connective tissue disease.

    Methods: We reviewed the records of all patients diagnosed with calciphylaxis while on renal replacement therapy at Tygerberg Hospital, Cape Town, South Africa, between 1990 and 2014, to describe its presentation, course and final outcome. Read More

    Vasculitic and autoimmune wounds.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 14;5(2):280-292. Epub 2016 Dec 14.
    Division of Rheumatology, The George Washington University, School of Medicine and Health Sciences, Washington, D.C.
    Objective: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions. Read More

    Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry.
    PLoS One 2017 17;12(2):e0172407. Epub 2017 Feb 17.
    Department of Medicine, Division of Nephrology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
    Introduction: Calciphylaxis/calcific uremic arteriolopathy affects mainly end-stage kidney disease patients but is also associated with malignant disorders such as myeloma, melanoma and breast cancer. Genetic risk factors of calciphylaxis have never been studied before.

    Methods: We investigated 10 target genes using a tagging SNP approach: the genes encoding CD73/ ecto-5'-nucleotidase (purinergic pathway), Matrix Gla protein, Fetuin A, Bone Gla protein, VKORC1 (all related to intrinsic calcification inhibition), calcium-sensing receptor, FGF23, Klotho, vitamin D receptor, stanniocalcin 1 (all related to CKD-MBD). Read More

    A Case of Nonuremic Calciphylaxis in a Caucasian Woman.
    Case Rep Dermatol Med 2017 16;2017:6831703. Epub 2017 Jan 16.
    Canberra Hospital, ACT Health, Canberra, ACT, Australia.
    We report a case of nonuremic calcific arteriolopathy (NUCA) in an 82-year-old Caucasian woman from rural Australia. The patient had no history of kidney disease or dialysis. NUCA is rare disease suspected on cutaneous and clinical features and diagnosed by characteristic findings on skin biopsy and vasculature imaging. Read More

    Conservative management of distal leg necrosis in lung transplant recipients.
    J Tissue Viability 2017 Jan 28. Epub 2017 Jan 28.
    Division of Pulmonology, University Hospital of Zurich, Switzerland. Electronic address:
    Critical limb ischemia (CLI) with distal leg necrosis in lung transplant recipients (LTR) is associated with a high risk for systemic infection and sepsis. Optimal management of CLI has not been defined so far in LTR. In immunocompetent individuals with leg necrosis, surgical amputation would be indicated and standard care. Read More

    Warfarin-Associated Nonuremic Calciphylaxis.
    JAMA Dermatol 2017 Jan 11. Epub 2017 Jan 11.
    Department of Dermatology, University of California-San Francisco, San Francisco.
    Importance: Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated calciphylaxis, present data from 2 others from our institution, and review all cases of warfarin-associated calciphylaxis available in the literature. Read More

    Patient Outcomes and Factors Associated with Healing in Calciphylaxis Patients Undergoing Adjunctive Hyperbaric Oxygen Therapy.
    J Am Coll Clin Wound Spec 2015 Dec 30;7(1-3):8-12. Epub 2016 Aug 30.
    Department of Emergency Medicine, Division of Hyperbaric Medicine and Wound Care, SUNY Upstate Medical University, 550 East Genesee Street, Suite 103, Syracuse, NY 13202, USA.
    Calcific uremic arteriolopathy, also known as calciphylaxis, is a rare syndrome of small vessel calcification of unknown etiology causing painful, violaceous skin lesions that progress to form chronic non-healing ulcers and gangrene. Hyperbaric oxygen therapy (HBOT) can be used as adjunctive therapy in the treatment of these ulcers. However, due to paucity of cases, there is limited data on the clinical benefit of HBOT and identifying factors associated with healing. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jan 3. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases.
    Joint Bone Spine 2016 Dec 7. Epub 2016 Dec 7.
    Pôle locomoteur, service de rhumatologie, centre Viggo Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris 7 Denis Diderot, Paris Cité Sorbonne, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:
    Intravenous sodium thiosulfate (ivSTS) is a promising new therapeutic option for calciphylaxis related to end-stage renal disease. However, its effect on tumoral calcinosis (TC) complicating autoimmune connective-tissue diseases has been scarcely described. We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. Read More

    Ischemic myopathy revealing systemic calciphylaxis.
    Muscle Nerve 2016 Dec 9. Epub 2016 Dec 9.
    Reference Center for Neuromuscular Diseases, Hôpital Henri Mondor APHP (Assistance Publique des Hôpitaux de Paris); INSERM U955-Team 10, Université Paris Est-Créteil, Créteil, France.
    Introduction: Patients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure-associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life-threatening condition usually observed in patients with end-stage renal disease on chronic dialysis or following renal transplantation.

    Methods: We describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis. Read More

    Penile calcific uremic arteriolopathy occurring postparathyroidectomy in a hemodialysis patient.
    Saudi J Kidney Dis Transpl 2016 Nov-Dec;27(6):1265-1269
    Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
    Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare condition most frequently seen in patients with advanced chronic kidney disease. The clinical picture is characterized by painful skin lesions and ulcerations. The underlying pathology is medial calcification and intimal proliferation with microthrombi of small arteries. Read More

    Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis.
    Intern Med 2016;55(22):3315-3320. Epub 2016 Nov 15.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
    Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. Read More

    Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen
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    Clin Nephrol 2016 Nov 14. Epub 2016 Nov 14.
    Background: Calciphylaxis in a nondialysis patient is a rare condition and is characterized by calcific deposition in tissue. We present a case of calciphylaxis in a nondialysis patient who was diagnosed by clinical presentation and skin biopsy and was treated with sodium thiosulfate with improvement of skin lesions.

    Case: A 43-year-old female with type 2 diabetes and atrial fibrillation taking oral anticoagulation medication presented with reddish drainage from the right buttock. Read More

    Resolution of Calciphylaxis After Urgent Kidney Transplantation in 3 Patients With End-Stage Kidney Failure.
    Transplant Direct 2016 Nov 25;2(11):e113. Epub 2016 Oct 25.
    Section of Nephrology, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Norway.
    Background: Calcific uremic arteriolopathy (CUA), also referred to as calciphylaxis, is a rare and serious complication of kidney failure with limited treatment options. Kidney transplantation (KTX) restores kidney function and is hence a potential treatment option for CUA. We present 3 patients who had their CUA lesions successfully healed after urgent KTX. Read More

    [Cutaneous manifestations in renal diseases].
    Hautarzt 2016 Dec;67(12):960-969
    Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Read More

    Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis.
    Iran Red Crescent Med J 2016 Aug 15;18(8):e30913. Epub 2016 Jun 15.
    Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Life Science, Tunghai University, Taichung, Taiwan.
    Introduction: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials.

    Case Presentation: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. Read More

    Generalized Weakness in a Transplant Patient: A Case Presentation.
    PM R 2016 Oct 16;8(10):1011-1015. Epub 2016 Apr 16.
    Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA(†).
    Generalized weakness in transplant patients is a major complaint in tertiary rehabilitation hospitals. The diagnosis and management of generalized weakness in this population pose challenges for physicians. We present the case of a transplant patient with generalized weakness who was eventually diagnosed with calciphylaxis using a multidisciplinary diagnostic approach of electrodiagnostics, vascular study, and skin biopsy. Read More

    Calciphylaxis: A Disease of Pannicular Thrombosis.
    Mayo Clin Proc 2016 Oct;91(10):1395-1402
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
    Objective: To identify coagulation risk factors in patients with calciphylaxis and the relationship between anticoagulation use and overall survival.

    Patients And Methods: Study subjects were 101 patients with calciphylaxis seen at Mayo Clinic from 1999 to September 2014. Data including thrombophilia profiles were extracted from the medical records of each patient. Read More

    Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis.
    Mayo Clin Proc 2016 Oct;91(10):1384-1394
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
    Objective: To report on the survival and the associations of treatments upon survival of patients with calciphylaxis seen at a single center.

    Patients And Methods: Using the International Classification of Diseases, Ninth Revision diagnosis code of 275.49 and the keyword "calciphylaxis" in the dismissal narrative, we retrospectively identified 101 patients with calciphylaxis seen at our institution between January 1, 1999, through September 20, 2014, using a predefined, consensus-developed classification scheme. Read More

    Calciphylaxis in peritoneal dialysis patients: a single center cohort study.
    Int J Nephrol Renovasc Dis 2016 19;9:235-241. Epub 2016 Sep 19.
    Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA.
    Background: Calciphylaxis is a rare but devastating condition in end-stage renal disease (ESRD) patients. Most research in the field of calciphylaxis is focused on hemodialysis (HD) patients; however, data on calciphylaxis incidence, risk factors, and mortality in peritoneal dialysis (PD) patients are limited.

    Methods: In this cohort study, we examined data from adult patients who initiated PD for ESRD management at our institute's PD unit from January 2001 to December 2015. Read More

    Plant phosphates, phytate and pathological calcifications in chronic kidney disease.
    Nefrologia 2017 Jan - Feb;37(1):20-28. Epub 2016 Sep 30.
    Laboratorio de Investigación en Litiasis Renal, Instituto de Ciencias de la Salud Investigación (IUNICS-IdISPa), Departamento de Química, Universidad de las Islas Baleares, Palma de Mallorca, Islas Baleares, España.
    Phytate, or myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate (InsP6), is a naturally occurring phosphorus compound that is present in many foods, mainly legumes, whole grains and nuts. Patients with chronic kidney disease (CKD) have cardiovascular disease mortality up to 30times higher than the general population. Vascular calcifications (VCs) directly contribute to overall morbidity and mortality, especially in CKD. Read More

    Bilateral optic neuropathy, acral gangrene and visceral ischaemia as a rare presentation of calciphylaxis: A case report.
    J Pak Med Assoc 2016 Oct;66(10):1324-1326
    Neurology Clinics, Ankara Ataturk Education and Research Hospital, Bilkent, Ankara, Turkey.
    We report a case with calciphylaxis very rarely presenting with bilateral optic neuropathy, acral gangrene and visceral ischaemia. Bilateral papilloedaema was found in a 43 year-old female with chronic renal failure. Acral dry gangrene was observed. Read More

    The efficacy and safety of sevelamer and lanthanum versus calcium-containing and iron-based binders in treating hyperphosphatemia in patients with chronic kidney disease: a systematic review and meta-analysis.
    Nephrol Dial Transplant 2016 Sep 20. Epub 2016 Sep 20.
    Department of Epidemiology & Biostatistics, Western University, London, ON, Canada Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Department of Anesthesia & Perioperative Medicine, Western University, Room B3-412, 339 Windermere Road, London, ON N6A 5A5, Canada.
    Background: It remains unclear which phosphate binders should be preferred for hyperphosphatemia management in chronic kidney disease (CKD).

    Methods: We performed a systematic review and meta-analysis of randomized trials comparing sevelamer or lanthanum with other phosphate binders in CKD.

    Results: Fifty-one trials (8829 patients) were reviewed. Read More

    Clinical Application and Pharmacodynamic Monitoring of Apixaban in a Patient with End-Stage Renal Disease Requiring Chronic Hemodialysis.
    Pharmacotherapy 2016 Nov 14;36(11):e166-e171. Epub 2016 Oct 14.
    Department of Pharmacy, Upstate University Hospital, Syracuse, New York.
    Despite prescribing guidance, limited data exist to describe the use of apixaban in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD). Current apixaban dosing recommendations for this patient population are based largely on a single-dose pharmacokinetic study of eight patients. We describe the clinical application and pharmacodynamic monitoring of apixaban in a 62-year-old 156-kg African-American woman with nonvalvular atrial fibrillation and ESRD requiring hemodialysis who developed calciphylaxis while receiving warfarin therapy. Read More

    Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology.
    Dermatology 2016 14;232(5):523-533. Epub 2016 Sep 14.
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists. They share the same clinical patterns: necrotizing livedo, skin infarctions at typical locations and acral gangrene in calciphylaxis. Read More

    Sodium Thiosulfate: Calciphylaxis.
    Hosp Pharm 2015 Nov 24;50(11):975-7. Epub 2015 Nov 24.
    Founder and Contributing Editor , The Formulary, and Editor, Off-Label Drug Facts , e-mail: .
    This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a publication available from Wolters Kluwer Health. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. This new guide to the literature enables the health care professional or clinician to quickly identify published studies on off-label uses and determine if a specific use is rational in a patient care scenario. Read More

    Cardiovascular calcifications in chronic kidney disease: Potential therapeutic implications.
    Nefrologia 2016 Nov - Dec;36(6):597-608. Epub 2016 Aug 30.
    Servicio de Nefrología, Fundació Puigvert, IIB Sant Pau, RedinRen, Barcelona, España.
    Cardiovascular (CV) calcification is a highly prevalent condition at all stages of chronic kidney disease (CKD) and is directly associated with increased CV and global morbidity and mortality. In the first part of this review, we have shown that CV calcifications represent an important part of the CKD-MBD complex and are a superior predictor of clinical outcomes in our patients. However, it is also necessary to demonstrate that CV calcification is a modifiable risk factor including the possibility of decreasing (or at least not aggravating) its progression with iatrogenic manoeuvres. Read More

    Case Report of Calciphylaxis Secondary to Calcium and Vitamin D3 Supplementation.
    J Cutan Med Surg 2016 Aug 26. Epub 2016 Aug 26.
    Department of Dermatology, University College Hospital, Galway, Ireland.
    Background: Calciphylaxis is a rare disorder that is very unusual outside the setting of end-stage kidney disease.

    Case Summary: A 64-year-old woman with normal renal function presented with painful leg ulcers. She had previously received 300 000 IU of vitamin D3 followed by daily calcium and vitamin D3 supplementation. Read More

    Hypothesis: Phytate is an important unrecognised nutrient and potential intravenous drug for preventing vascular calcification.
    Med Hypotheses 2016 Sep 12;94:89-92. Epub 2016 Jul 12.
    Laboratoris Sanifit, Parc Bit, Palma de Mallorca, Spain; Institute of Health Sciences Research, University of Balearic Sciences, Palma de Mallorca, Spain.
    Cardiovascular calcification (CVC) associated with conditions such as ageing, diabetes or renal impairment, results from the deposition of hydroxyapatite in the endothelium or media of blood vessels. Key medical management options are directed towards controlling plasma calcium and phosphate concentrations (e.g. Read More

    Successful Management of Calciphylaxis in a Kidney Transplant Patient: Case Report.
    Transplant Direct 2016 Apr 17;2(4):e70. Epub 2016 Mar 17.
    Renal Division, University Medical Center Freiburg, Freiburg, Germany.
    Unlabelled: Calciphylaxis is a rare and often fatal condition mostly associated with end-stage renal disease. The pathophysiology remains elusive and treatment options are scarce. We present a rare case of severe calciphylaxis after kidney transplantation in a patient with persistent hyperparathyroidism. Read More

    Calciphylaxis following acute renal injury: a case and literature review.
    Springerplus 2016 11;5(1):1043. Epub 2016 Jul 11.
    Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan.
    Background: Calciphylaxis following acute renal failure is rare.

    Findings: We report A 57-year-old male with an acute renal failure associated with necrotizing fasciitis. We also review the cases of calciphylaxis due to acute renal disorder further. Read More

    Calciphylaxis - A case study in a patient with Maori heritage.
    J Tissue Viability 2016 Nov 5;25(4):216-219. Epub 2016 Jul 5.
    School of Podiatry, Health & Rehabilitation Research Institute, Auckland University of Technology, Private Bag 92006, Auckland 1142, New Zealand; School of Health Science, University of Brighton, 49 Darley Rd, Eastbourne BN20 7UR, UK. Electronic address:
    This case history describes a rare complaint - Calciphylaxis, seen in a New Zealand Maori patient undergoing renal dialysis. This condition causes non-healing tissue ulceration, typically with sepsis and is associated with a very high mortality rate. The need for vigilance among health professionals is highlighted, including the risk factors that may faciliate an early diagnosis; together with the value associated with a multi-disciplinary team approach to management. Read More

    The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
    Intern Med 2016 15;55(14):1899-905. Epub 2016 Jul 15.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
    We present the case of a non-dialyzed patient with chronic kidney disease and biopsy-proven calciphylaxis who presented with painful cutaneous ulcers on both legs. The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy. Notably, the patient's serum levels of C-reactive protein and calciprotein particles decreased and her serum albumin and fetuin-A levels increased in parallel with the alleviation of her calciphylaxis. Read More

    [Calciphylaxis. A review of 9 cases].
    Med Clin (Barc) 2016 Aug 13;147(4):157-61. Epub 2016 Jul 13.
    Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona, España.
    Background And Objective: Calciphylaxis is a cutaneous ischaemic vascular disease of small vessels with high morbidity and mortality. To date very few series of patients with this disease have been published, none from a Spanish hospital. The main objectives of this work are to analyze the demographic, clinical and histological profile of patients diagnosed in our department to identify risk factors and potential therapeutic strategies. Read More

    Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis.
    PLoS One 2016 8;11(7):e0158196. Epub 2016 Jul 8.
    Service of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
    Objectives: Calcium-containing crystals participate in the pathogenesis of OA. Sodium thiosulfate (STS) has been shown to be an effective treatment in calcification disorders such as calciphylaxis and vascular calcification. This study investigated the effects and mechanisms of action of STS in a murine model of OA and in chondrocyte calcification. Read More

    Calciphylaxis of the Breast: A Case Report and Literature Review.
    Breast J 2016 Sep 22;22(5):568-72. Epub 2016 Jun 22.
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
    Calciphylaxis, or calcific uremic arteriolopathy, is a rare but particularly morbid condition involving systemic medial calcification of arterioles causing ischemia and subsequent tissue necrosis. Although most commonly occurring over the abdomen and proximal extremities, calciphylaxis can present on nearly any skin surface with a tendency toward areas of increased adiposity. We report a case of a 53-year-old female with end-stage renal disease who presented with bilateral palpable breast masses and overlying skin changes. Read More

    Warfarin-induced calciphylaxis in patients with normal renal function.
    J Clin Pharm Ther 2016 Aug 19;41(4):449-452. Epub 2016 Jun 19.
    Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
    What Is Known And Objective: Calciphylaxis is a rare and potentially life-threatening cause of skin necrosis and is poorly recognized by clinicians in non-uraemic patients.

    Case Description: We report five cases of warfarin-induced calciphylaxis in patients with normal renal function. In four cases, sodium thiosulphate was successfully used as a treatment. Read More

    [A man with an ulcer on his penis].
    Ned Tijdschr Geneeskd 2016 ;160:A9909
    St. Antonius Ziekenhuis, afd. Vaatchirurgie, Nieuwegein.
    A 51-year-old male presented with a painful ulcer on his glans penis. Histopathological and radiological examination showed extensive microangiopathy and calcification of small and medium-sized arteries and the diagnosis 'calciphylaxis cutis' was made. Calciphylaxis cutis is caused by calcium deposits in small and medium-sized arteries, and most commonly seen in patients with end-stage renal failure and hyperparathyroidism. Read More

    Integral pharmacological management of bone mineral disorders in chronic kidney disease (part II): from treatment of phosphate imbalance to control of PTH and prevention of progression of cardiovascular calcification.
    Expert Opin Pharmacother 2016 Jul 17;17(10):1363-73. Epub 2016 May 17.
    a Department of Nephrology , Fundació Puigvert, IIB Sant Pau, RedinRen , Barcelona , Spain.
    Introduction: Chronic kidney disease-mineral and bone disorders (CKD-MBD) are associated with costly complications and dismal hard-outcomes.

    Areas Covered: In two comprehensive articles we review contemporary and future pharmacological options for treatment of phosphate (P) imbalance (part 1) and hyperparathyroidism (this part 2), taking into account CKD-accelerated cardiovascular calcification (CVC) processes.

    Expert Opinion: Improvements in CKD-MBD require an integral approach, addressing all three components of the CKD-MBD triad. Read More

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