43,476 results match your criteria Calcinosis Cutis
J Med Case Rep 2018 Dec 12;12(1):366. Epub 2018 Dec 12.
Department of Dermatology and Venereology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.
Background: Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. Idiopathic calcinosis cutis of the scrotum is an uncommon entity. The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. Read More
J Cardiol Cases 2013 Dec 29;8(6):183-186. Epub 2013 Oct 29.
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
A 47-year-old Japanese woman was transported to our hospital due to acute heart failure (AHF). She had been diagnosed with primary hyperparathyroidism (pHPT) and undergone parathyroidectomy 3 months previously. Chest X-ray showed marked cardiomegaly and severe pulmonary congestion, and transthoracic echocardiography indicated both left ventricular (LV) systolic and diastolic dysfunction, complicated with extensive massive myocardial calcification and no LV hypertrophy. Read More
Angiol Sosud Khir 2018 ;24(4):43-48
Research Centre of Neurology, Moscow, Russia.
The authors revealed relation between the structure of an atherosclerotic plaque (ASP) and intensity of the ultrasound signal reflected form the ASP. Our prospective pilot study included a total of 90 patients (71 men and 19 women aged from 47 to 79 years, with the median age 62 years) presenting with atherosclerotic stenosis of the carotid sinus (CS) and undergoing treatment at the Research Centre of Neurology (Moscow) from April 2015 to March 2016. All patients underwent ultrasonographic examination followed by morphological study of the structure of the plaques removed during carotid endarterectomy (CEA). Read More
Intern Med J 2018 Dec;48(12):1544-1546
Department of Nephrology, The Third Affiliated Hospital, Soochow University, Changzhou, China.
Biochemistry (Mosc) 2018 Nov;83(11):1350-1357
Göring Consulting, Berlin, 12555, Germany.
The review discusses the data on vitamin D accumulation in animals, plants, and other organisms. 7-Dehydrocholesterol (7-DHC) and ergosterol are considered to be the only true precursors of vitamin D, although even vitamin D (ergocalciferol) is not fully comparable to vitamin D (cholecalciferol) in regard to their functions. These precursors are converted by UV radiation into the corresponding D vitamins. Read More
JAMA Dermatol 2018 Nov 21. Epub 2018 Nov 21.
Division of Dermatology, Department of Medicine, The Ohio State University, Columbus.
Medicine (Baltimore) 2018 Nov;97(47):e13319
Rationale: Dystrophic calcinosis occurs in chronically damaged tissue in patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic calcinosis treated with leflunomide in a patient with overlap syndrome. Read More
Pediatr Clin North Am 2019 Feb;66(1):135-157
Division of Nephrology, Department of Pediatrics, The Montreal Children's Hospital, McGill University Health Centre, Room B RC.6651, Montreal, Quebec H4A 3J1, Canada; Al Jalila Children's Hospital, Al Jadaf PO Box 7662, Dubai, UAE. Electronic address:
Renal tubular acidosis should be suspected in poorly thriving young children with hyperchloremic and hypokalemic normal anion gap metabolic acidosis, with/without syndromic features. Further workup is needed to determine the type of renal tubular acidosis and the presumed etiopathogenesis, which informs treatment choices and prognosis. The risk of nephrolithiasis and calcinosis is linked to the presence (proximal renal tubular acidosis, negligible stone risk) or absence (distal renal tubular acidosis, high stone risk) of urine citrate excretion. Read More
J Dermatol 2018 Nov 16. Epub 2018 Nov 16.
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
The objective was to evaluate the demographic and clinical characteristics of systemic sclerosis (SSc) patients with spinal calcinosis. Paraspinal and intraspinal calcinosis was assessed blindly by orthopedic surgeons specializing in spinal diseases using chest high-resolution computed tomography (CT) that was performed for the screening and prospecting of interstitial lung disease in 159 Japanese SSc patients. Among these patients, we identified 27 (17%) with spinal calcinosis, and the most common site was cervical level at 77. Read More
Clin Immunol 2018 Nov 13;198:11-18. Epub 2018 Nov 13.
Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Background: Several complications like calcinosis, interstitial lung disease (ILD) or malignancy, are primary causes leading to poor outcomes in idiopathic inflammatory myopathies (IIM) patients. Specific antibodies might help to indicate the occurrence or absence of these complications.
Objective: The aim of this study was to evaluate the association of anti-nuclear matrix protein 2 antibody (anti-NXP2) with calcinosis, ILD and malignancy in IIM patients. Read More
J Comput Assist Tomogr 2018 Nov/Dec;42(6):887-897
From the Johns Hopkins Hospital, Baltimore, MD.
Coronary artery calcium is a marker of overall atherosclerotic plaque burden, corresponding to approximately 20% overall atherosclerotic plaque burden. Coronary artery calcium screening, most commonly performed using the Agatston score, has been shown to be a predictor of future cardiovascular risk independent of conventional risk scores such as the Framingham risk score. Coronary artery calcium screening is also recommended on routine nongated, noncontrast chest computed tomography scans using several ordinal and visual scoring systems. Read More
Medicine (Baltimore) 2018 Oct;97(43):e12824
Department of Radiology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
The aim of the current study was to enhance the awareness of phlebosclerotic colitis (PC) through our clinical experience.A retrospective review of 25 patients who were diagnosed as PC in our 2 affiliated hospitals from January 2013 to October 2017 was conducted.The patients were found at a mean age of 63. Read More
Respir Investig 2018 Nov 24;56(6):457-463. Epub 2018 Oct 24.
Division of Infection Control and Prevention, National Cancer Center Hospital, Tokyo, Japan; Center for Nutrition Support and Infection Control, Gifu University Hospital, Gifu, Japan.
Background: Bronchoscopy is important to diagnose lung cancer. However, some patients who undergo bronchoscopic procedures develop respiratory tract infections. Little is known about the proportion of pathogen-positive results in bacterial cultures from diagnostic bronchoscopy samples in patients with suspected lung cancer. Read More
Korean J Radiol 2018 Nov-Dec;19(6):1147-1160. Epub 2018 Oct 18.
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Soft-tissue calcification refers to a broad category of lesions. Calcifications are frequently identified by radiologists in daily practice. Using a simple algorithm based on the distribution pattern of the lesions and detailed clinical information, these calcified lesions can be systematically evaluated. Read More
Medicine (Baltimore) 2018 Nov;97(44):e13107
Department of Radiology, Tongde Hospital of Zhejiang Province.
Rationale: Primary hyperparathyroidism (PHPTI) with respiratory tract symptom is extremely rare. It is caused by autonomic oversecretion of parathyroid hormone (PTH) owing to parathyroid adenoma, hyperplasia, or tumor. The diagnosis of PHPTI often needs to be made based on medical history, clinical manifestation, laboratory tests, and imaging examination. Read More
J Comput Assist Tomogr 2018 Nov/Dec;42(6):912-918
Objective: The aim of this study was to investigate the quantitative and qualitative effects of virtual monoenergetic images (VMI) by spectral detector computed tomography (SDCT) on calcium blooming in coronary computed tomography angiography.
Methods: Coronary computed tomography angiography using SDCT was performed on 42 patients with coronary artery calcifications. Stenosis grading by diameter and area of calcified plaques and free lumen using VMI from 70 to 140 keV was performed and compared with measurements by conventional images. Read More
Am J Surg Pathol 2018 Oct 26. Epub 2018 Oct 26.
Department of Pathology.
The term "idiopathic calcifying tenosynovitis" (ICT) refers to a clinically and radiologically defined syndrome of pain and tendinous calcifications, most often involving the shoulder joint. A distinctive subset of ICT cases, termed "tenosynovitis with psammomatous calcifications" (TPC), occurs in the distal extremities and shows characteristic morphology, in particular psammomatous calcifications. As only 14 cases have been reported to date, TPC remains poorly recognized by both pathologists and clinicians. Read More
Am J Med Sci 2018 Oct 13;356(4):e35. Epub 2018 Jun 13.
Department of Rheumatology, State University of New York Downstate Medical Center, Brooklyn, New York. Electronic address:
Cureus 2018 Aug 21;10(8):e3170. Epub 2018 Aug 21.
Dermatologist, San Diego Family Dermatology, San Diego, USA.
Osteoma cutis is the formation of bone within the skin. It can present as either primary osteoma cutis or secondary osteoma cutis. Secondary osteoma cutis is more common and is associated with inflammatory, infectious, and neoplastic disorders, including basal cell carcinoma. Read More
Front Pediatr 2018 9;6:284. Epub 2018 Oct 9.
Department of Pediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.
Juvenile dermatomyositis (JDM) is a rare autoimmune disease mainly characterized by muscle and skin involvement. Vasculopathy is considered central to the pathogenesis of the disease. The exact nature of vasculopathy is not yet understood but it is a complex process with both an inflammatory and a non-inflammatory, occlusive component. Read More
Pan Afr Med J 2018 29;30:82. Epub 2018 May 29.
Service de Médecine Interne B, Hôpital Charles Nicolle, Tunis, Tunisie.
Fahr syndrome is a rare disorder, whose prevalence is lower than 0.5%. Clinical manifestations are variable ranging from mere behavioral disorders to tetany crises and severe neuropsychiatric manifestations. Read More
Medicina (Kaunas) 2018 Apr 25;54(2). Epub 2018 Apr 25.
Department of Cardiology, Medical Academy, Hospital of Lithuanian University of Health Sciences, Eivenių g. 2, 50161 Kaunas, Lithuania.
Degenerative aortic stenosis (DAS) is the most frequently diagnosed heart valve disease in Europe and North America. DAS is a chronic progressive disease which resembles development of atherosclerosis. Endothelial dysfunction, lipid infiltration, calcification and ossification are evidenced in both diseases. Read More
Best Pract Res Clin Gastroenterol 2018 Jun - Aug;34-35:49-54. Epub 2018 May 23.
Dept. of Surgery, Oncology and Gastroenterology, University of Padova, Italy.
Patients with PBC have at least 60% of probability to have an autoimmune extrahepatic condition. The pathogenesis of these conditions includes a common mechanism involving both innate and adaptive immune responses targeting cholangiocytes and different extrahepatic tissues. The recent EASL guidelines recommend the management of these conditions, although detailed practical treatments have not been indicated. Read More
Medicine (Baltimore) 2018 Oct;97(42):e12918
Department of Psychiatry.
Idiopathic basal ganglia calcification (IBGC) is characterized by brain calcification and a wide variety of neurological and psychiatric symptoms. In families displaying an autosomal dominant inheritance pattern, three causative genes have been identified: SLC20A2, PDGFRB, and very recently, PDGFB. While in clinical practice sporadic presentation of IBGC is frequent, well-documented reports of true sporadic occurrences are rare. Read More
Medicine (Baltimore) 2018 Oct;97(41):e12675
Department of Pathology, Kosin University College of Medicine, Busan, Korea.
Ultrasonographic microcalcification is highly related to papillary thyroid cancer (PTC) and pathologic psammoma body is a poor prognostic factor. However, it is little known about whether the microcalcifications seen on ultrasonography are consistent with the pathologic psammoma bodies. We evaluated the relationship between ultrasonographic (US) calcification types and pathologic calcification features, and the consistency between observed pathologic and US calcifications. Read More
Heart Surg Forum 2018 Sep 13;21(5):E375-E381. Epub 2018 Sep 13.
Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Background: Chemically cross-linked animal tissues, such as porcine aortic valves (PAVs) have many documented advantages over mechanical valves. However, calcification is the major underlying pathologic process that results in bioprosthetic valve failure. Recently, several reports described the expression of noncollagenous bone matrix proteins in bioprosthetic valves and suggested an actively regulated process of tissue repair. Read More
J Cutan Pathol 2018 Oct 12. Epub 2018 Oct 12.
Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Acquired perforating calcific collagenosis (APCC), which is characterized by the calcification of dermal collagen fibers with subsequent transepidermal elimination and perforation, is an extremely rare entity. Thus far, it has only been reported in a patient with direct contact exposure to calcium chloride. Here, we report a unique case of APCC occurring in a drug addict admitted for rhabdomyolysis. Read More
J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295
Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.
With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More
J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1296
Universität des Saarlandes, Kliniken für Kinder- und Jugendmedizin, Sektion Pädiatrische Endokrinologie und Diabetologie, Homburg.
Das Down-Syndrom (DS) ist mit einer Inzidenz von 1 : 700 aller Geburten nicht selten und mit diversen Erkrankungen unterschiedlicher Organsysteme assoziiert. Zu den schwerwiegenden Erkrankungen zählen Herzfehler und Leukämie. Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leukämie über (transiente myeloproliferative Erkrankung). Read More
Rev Esp Med Nucl Imagen Mol 2018 Oct 2. Epub 2018 Oct 2.
Servicio de Medicina Nuclear, Hospital Universitari Son Espases, Palma de Mallorca, España; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, España.
J Med Syst 2018 Oct 3;42(11):221. Epub 2018 Oct 3.
Department of ECE, Mahendra College of Engineering, Salem, India.
Breast cancer is the important problem across the globe in which, most of the women are suffering without knowing the causes and effects of the cancer cells. Mammographic is the most powerful tool for the diagnosis of the Breast cancer. The analysis of this mammogram images proves to be more vital in terms of diagnosis but the accuracy level still needs improvisation. Read More
Rev Fac Cien Med Univ Nac Cordoba 2018 06 30;75(2):139-142. Epub 2018 Jun 30.
Hospital Privado Universitario de Córdoba.
Primary Sjögren's syndrome is a systemic and chronic autoimmune disease. Renal involvement may occur in up to 30% of patients. The incidence of tubulopathies ranges from 2. Read More
Int J Low Extrem Wounds 2018 Oct 1:1534734618799576. Epub 2018 Oct 1.
1 Department of Dermatology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Leg ulcers are not a disease themselves, they are a symptom of a disease. To manage them properly, finding the correct diagnosis of the disease is mandatory. Our case is a model to underline that leg ulcers are a significant burden for the patient, because leg ulcer got ahead of the patient's other serious complaints such as Raynaud's phenomenon or sclerodactyly. Read More
J Genet 2018 Sep;97(4):939-944
Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, Hebei, People's Republic of China.
Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive disorder with distinctive deposition of calcium phosphate microliths in the lungs. Mutation of the gene was proved to be responsible for PAM. Here, we report the study of a family affected by PAM in China. Read More
Clin Exp Dermatol 2018 Sep 25. Epub 2018 Sep 25.
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
In this case series, we retrospectively identified all patients treated with topical sodium thiosulfate (TST) for calcinosis cutis (CC) associated with underlying autoimmune connective tissue diseases at Mayo Clinic (Rochester, MN, USA) during the period 1 January 2012 to 27 June 2017. Of 28 patients identified (mean age 57.0 years; 96% female), 19 (68%) had clinical improvement of their CC with TST, 7 (25%) had no response and 2 (7%) had unknown response. Read More
Eur Heart J Cardiovasc Imaging 2018 Nov;19(11):1195-1221
Department of Cardiology, University of Liege Hospital, GIGA Cardiovascular Sciences, B35, Avenue de l'Hôpital, 1, Liege, Belgium.
The main goal of the present document is to provide a set of practical recommendations for ultrasound imagers who are interested in artery diseases or for physicians who intend to undertake vascular procedures. This is the first part of the work. It is dedicated to general principles of ultrasonography, cervicoencephalic, subclavian, aortoiliac and lower extremity arteries, abdominal aorta, and popliteal aneurysms. Read More
Lancet 2018 09;392(10151):950
Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
Medicine (Baltimore) 2018 Sep;97(38):e12517
Department of Orthopaedic Surgery, Kyung Hee University Hospital, College of medicine, Kyung Hee University, Seoul, Korea.
Rationale: Calcific myonecrosis is a very rare late sequela that occurs in patients who have had trauma accompanied by vascular compromise, in which a single muscle or entire muscles in a compartment undergoes necrosis and form a calcified mass. It is mostly a benign entity, but some cases cause bone destruction and form non-healing chronic sinuses. In such cases, wound management becomes difficult and there is a potential risk of secondary infection. Read More
Ren Fail 2018 Nov;40(1):520-526
a Department of Nephrology , Children's Hospital of Fudan University , Shanghai , China.
Objective: Primary distal renal tubular acidosis (dRTA) is a rare genetic disease characterized by distal tubular dysfunction leading to metabolic acidosis and alkaline urine. Growth retardation is a major concern in these children. The disease is caused by defects in at least three genes (SLC4A1, ATP6V0A4, and ATP6V1B1) involved in urinary distal acidification. Read More
Retin Cases Brief Rep 2018 Fall;12(4):331-335
Vitreous Retina Macula Consultants of New York, New York.
Purpose: To report the posterior segment and retinal vascular manifestations of calcific uremic arteriolopathy (calciphylaxis). Clinical findings are correlated with multimodal imaging results.
Methods: Observational case report. Read More
J Clin Invest 2018 Dec 29;128(12):5368-5373. Epub 2018 Oct 29.
Skeletal Disorders and Mineral Homeostasis Section, and.
Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. Read More
J Card Surg 2018 10 14;33(10):646-648. Epub 2018 Sep 14.
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan.
Med Phys 2018 Nov 1;45(11):4793-4805. Epub 2018 Oct 1.
Department of Radiology, Turku University Hospital, Kiinamyllynkatu 4-8, 20521, Turku, Finland.
Purpose: Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localized treatment of prostate cancer. One of the limiting factors of this therapy is prostatic calcifications. These attenuate and reflect ultrasound and thus reduce the efficacy of the heating. Read More
Sultan Qaboos Univ Med J 2018 May 9;18(2):e236-e238. Epub 2018 Sep 9.
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Bhopal, India.
Pulmonary alveolar microlithiasis (PAM) is an uncommon entity which can pose a diagnostic challenge. We report a 45-year-old female who was referred to the All India Institute of Medical Sciences, Bhopal, India, in 2017 with a two-year history of progressively worsening dyspnoea and dry coughing. She had been previously diagnosed with pulmonary tuberculosis elsewhere and prescribed antitubercular therapy; however, there was little improvement in her symptoms. Read More
Osteoporos Int 2018 Sep 11. Epub 2018 Sep 11.
Center For Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Generalized arterial calcification of infancy (GACI) is a rare genetic disorder with high infantile mortality, described to be due to ENPP1, and less commonly ABCC6 mutations. Bisphosphonate treatment has been described to improve survival in ENPP1-positive GACI patients, but few studies have described bisphosphonate treatment in ABCC6-positive patients. Without therapy, patients will die before 6 months of age. Read More
Medicine (Baltimore) 2018 Sep;97(36):e12255
Department of Radiotherapy, Hebei Provincial Hospital of Chinese Medicine, Hebei University of Chinese Medicine, Shijiazhuang.
Rationale: Tuberculosis remains a serious menace to the health of people. Isolated hepatic tuberculosis is rare and pancreatic tuberculosis is extremely rare. The preoperative diagnosis of pancreatic tuberculosis remains a great challenge. Read More
J Card Surg 2018 10 10;33(10):651-652. Epub 2018 Sep 10.
Department of Cardiovascular Surgery, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Seizure 2018 10 29;61:199. Epub 2018 Aug 29.
Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: