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    2591 results match your criteria Calcinosis Cutis

    1 OF 52

    [A man with strange genital warts].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1715
    Catharina Ziekenhuis, afd. Dermatologie, Eindhoven.
    A 36-year-old man came to the outpatient dermatology department with asymptomatic, skin-coloured to white/yellow, firm papules on his prepuce. Over the last 10 years he had received different treatments for condylomata accuminata, with no effect. After shave excision, the diagnosis of idiopathic calcinosis cutis was made. Read More

    Points to consider for skin ulcers in systemic sclerosis.
    Rheumatology (Oxford) 2017 Sep;56(suppl_5):v67-v71
    Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy.
    This article discusses points to consider when undertaking a clinical trial to test therapy for skin ulcers in SSc. A validated definition of skin ulcers should be used if available. Defining a uniform SSc patient population, including consideration of disease duration, history of digital ulcers and capillaroscopic patterns, is important. Read More

    Bilateral leg ulcers secondary to dystrophic calcinosis in a patient with rheumatoid arthritis.
    J Med Invest 2017 ;64(3.4):308-310
    Department of Dermatology, Tokushima University Graduate School of Medical Science.
    Calcinosis cutis can be classified into four subtypes: dystrophic, metastatic, idiopathic, and iatrogenic. Of these subtypes, dystrophic calcinosis (DC) is the most common, and is most frequently associated with connective tissue disease, particularly dermatomyositis and systemic sclerosis, and less commonly with systemic lupus erythematosus. However, DC associated with rheumatoid arthritis (RA) is extremely rare. Read More

    Extensive Dystrophic Calcinosis Cutis: A Severe Complication of Polymyositis/Systemic Sclerosis Overlap Syndrome.
    J Clin Rheumatol 2017 Sep 19. Epub 2017 Sep 19.
    From the *Department of Medicine, Cairns Hospital; and †College of Medicine and Dentistry, James Cook University Cairns Campus, Cairns; ‡The Kirby Institute, University of New South Wales, Sydney; and §Menzies School of Health Research, Darwin, Australia.

    CALCINOSIS CIRCUMSCRIPTA IN A COHORT OF RELATED JUVENILE AFRICAN LIONS (PANTHERA LEO).
    J Zoo Wildl Med 2017 Sep;48(3):813-817
    Three juvenile, genetically related African lions (Panthera leo) were evaluated for discrete dome-shaped subcutaneous masses present over the proximal lateral metatarsal-tarsal area. The lesions measured 3-8 cm in diameter, were fluctuant to firm, nonulcerated, and attached to underlying structures. On radiographic evaluation, the lesions were characterized by well-circumscribed punctate mineralizations in the soft tissue surrounded by soft tissue swelling without evidence of adjacent bony involvement. Read More

    Juvenile Dermatomyositis: Key Roles of Muscle Magnetic Resonance Imaging and Early Aggressive Treatment.
    Actas Dermosifiliogr 2017 Sep 11. Epub 2017 Sep 11.
    Servicio de Dermatología, Hospital Universitario Son Espases, Palma de Mallorca, España.
    Juvenile dermatomyositis is a rare systemic connective tissue disease with onset during childhood. It presents clinically with proximal muscle weakness and characteristic skin involvement. Diagnosis is based on the Bohan and Peter criteria, though many authors are now substituting biopsy with muscle magnetic resonance imaging (MRI) for both diagnosis and follow-up. Read More

    Endothelin-1, α-Klotho, 25(OH) Vit D levels and severity of disease in scleroderma patients.
    Rheumatol Int 2017 Oct 22;37(10):1651-1657. Epub 2017 Aug 22.
    Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Considering the role of endothelin-1 (ET-1) in tissue remodeling and fibrosis during the development of scleroderma as well as the effect of α-Klotho in pathogenesis of calcinosis and/or endothelial cell injury and its correlation with severity of disease, this study aimed to evaluate serum ET-1, α-Klotho and 25(OH) vitamin D levels in patients with limited and diffuse scleroderma compared to healthy subjects. In this cross-sectional study, 60 scleroderma patients according to the ACR/EULAR 2013 criteria and 60 age- and sex-matched healthy controls were included. In patients, clinical examination was performed and Medsger severity scale was assessed. Read More

    Idiopathic Calcinosis Cutis Universalis Treated Successfully with Oral Diltiazem-A Case Report.
    Pediatr Dermatol 2017 Sep 2;34(5):e241-e244. Epub 2017 Aug 2.
    Department of Dermatology, SMS Medical College & Hospital, Jaipur, Rajasthan, India.
    Idiopathic calcinosis cutis is very rare and difficult to treat. Various medical modalities of treatment described with inconsistent results include chelating agents, colchicine, and probenecid. Calcium channel blockers are known to work by inhibiting intracellular entry of calcium. Read More

    Quartz Crystal Microbalance Assay of Clinical Calcinosis Samples and Their Synthetic Models Differentiates the Efficacy of Chelation-Based Treatments.
    ACS Appl Mater Interfaces 2017 Aug 15;9(33):27544-27552. Epub 2017 Aug 15.
    Manchester Institute of Biotechnology, University of Manchester , 131 Princess Street, Manchester, M1 7DN, U.K.
    This paper sets out in vitro protocols for studying the relative effectiveness of chelators used in the dissolution-based treatment of hard calcinosis. Pulverized hard calcinosis samples from human donors or synthetic hydroxyapatite nanoparticles were deposited by electrophoretic deposition on the surface of a quartz crystal microbalance sensor. Over 150 deposits of <20 μg were dissolved over the course of 1 h by aliquots of buffered, aqueous solutions of two calcium chelators, EDTA and citrate, with the surface-limited dissolution kinetics monitored with <1 s time resolution. Read More

    Phenotypic characteristics and outcome of juvenile dermatomyositis in Arab children.
    Rheumatol Int 2017 Jul 6. Epub 2017 Jul 6.
    Consultant and Section Head, Rheumatology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Po Box 3354, Riyadh, 11211, Saudi Arabia.
    This study describes the disease characteristics and outcome of Arab children with juvenile dermatomyositis (JDM) and compares the findings with other ethnicities. We retrospectively reviewed the hospital registries of the participating hospitals for children with JDM seen between 1990 and 2016 in three Arab countries. All patients fulfilled Bohan and Peter criteria for JDM, diagnosed before 14 years of age and were of Arab ethnicity. Read More

    Management of a Complex Peristomal Calciphylaxis: A Case Study.
    J Wound Ostomy Continence Nurs 2017 Jul/Aug;44(4):380-383
    Mary Famorca, MAN, RN, WCC, COCN, Mayo Clinic Arizona, Phoenix, Arizona. Debra Beauchaine, MN, RN, AGPCNP, CWOCN-AP, Mayo Clinic Arizona, Phoenix, Arizona. Nancy Angulo, BS, RN, CWOCN, Cancer Treatment Center of America, Goodyear, Arizona.
    Background: Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare and serious syndrome of small blood vessels with a high mortality rate. Calciphylaxis lesions require intensive wound management with medical interventions for the patient to survive the sequelae of sepsis and present unique challenges when found in the peristomal skin.

    Case: A 33-year-old man presented with multiple malodorous stage 4 pressure injuries of his sacrococcygeal and gluteal area. Read More

    Metastatic calcinosis cutis in end-stage renal disease.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):368-369
    Department of Internal Medicine, Baylor Scott and White Hospital and Texas A&M Health Science Center College of Medicine, Temple, Texas.
    Alterations in calcium and phosphorus levels and joint pain are a common occurrence in end-stage renal disease patients. However, metastatic calcinosis cutis is a rare diagnosis that often combines these two findings, with extensive soft tissue calcification surrounding a large joint being the hallmark of this disease. The exact mechanism behind this clinical entity is unknown. Read More

    Lack of Response to Intravenous Sodium Thiosulfate in Three Cases of Extensive Connective Tissue Disease-Associated Calcinosis Cutis.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Brigham and Women's Hospital, Department of Dermatology, Harvard Medical School.
    Dystrophic calcinosis cutis is a debilitating condition of calcium salt deposition in the skin often occurring in association with connective tissue disease (CTD). Available treatments for calcinosis cutis are unsatisfactory, but given the recent use of topical and intralesional sodium thiosulfate (STS) to treat calcifying disorders, we sought to describe the use of intravenous (IV) STS for CTD-associated dystrophic calcinosis cutis. We report three patients with longstanding and extensive CTD-associated calcinosis cutis treated with IV STS after having failed multiple prior therapies. Read More

    High-Velocity Paint Gun Injuries.
    Am J Dermatopathol 2017 Aug;39(8):606-613
    *Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX; †Department of Pathology, University of Colorado, Denver, CO; ‡Western Pathology, Inc., San Luis Obispo, CA; and §Loyola Stritch School of Medicine, Chicago, IL.
    Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. Read More

    Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy.
    Arthritis Rheumatol 2017 Oct 22;69(10):2081-2091. Epub 2017 Aug 22.
    INSERM UMR 1163, Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, and Hôpital Necker Enfants Malades, AP-HP Paris, Paris, France, and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Objective: To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet, including camptodactyly, subluxation, and tendon rupture, reminiscent of Jaccoud's arthropathy.

    Methods: We identified 2 families segregating an autosomal-dominant phenotype encompassing musculoskeletal disease and variable additional features, including psoriasis, dental abnormalities, cardiac valve involvement, glaucoma, and basal ganglia calcification. We measured the expression of interferon (IFN)-stimulated genes in the peripheral blood and skin, and undertook targeted Sanger sequencing of the IFIH1 gene encoding the cytosolic double-stranded RNA (dsRNA) sensor melanoma differentiation-associated protein 5 (MDA-5). Read More

    Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules.
    PLoS One 2017 11;12(5):e0177375. Epub 2017 May 11.
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Gamma-glutamyl carboxylase (GGCX) gene mutation causes GGCX syndrome (OMIM: 137167), which is characterized by pseudoxanthoma elasticum (PXE)-like symptoms and coagulation impairment. Here, we present a 55-year-old male with a novel homozygous deletion mutation, c.2,221delT, p. Read More

    CREST Calcinosis Affecting the Lumbar and Cervical Spine and the Use of Minimally-Invasive Surgery.
    Cureus 2017 Apr 8;9(4):e1145. Epub 2017 Apr 8.
    Michigan Head and Spine Institute, Oakland University William Beaumont School of Medicine.
    Calcinosis in CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome can affect the spinal and paraspinal areas. We present the first case to our knowledge where a CREST syndrome patient required surgery for spinal calcinosis in both the cervical and lumbar areas. A 66-year-old female with a history of CREST syndrome presented with right-sided lower extremity radicular pain. Read More

    Subepidermal Calcinosis in the Ocular Adnexa: A Systematic Review.
    Ophthal Plast Reconstr Surg 2017 Apr 20. Epub 2017 Apr 20.
    *Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, and †Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, U.S.A.
    Purpose: To review the clinical and histopathologic findings associated with subepidermal calcinosis of the eyelids.

    Methods: A systematic review of the literature on subepidermal calcinosis of the eyelids was performed. Cases included were idiopathic in nature and met the histologic criteria for subepidermal calcinosis with calcium deposits in the dermis of the skin. Read More

    Iatrogenic Calcinosis Cutis Successfully Treated with Topical Sodium Thiosulfate.
    Pediatr Dermatol 2017 May 6;34(3):356-358. Epub 2017 Apr 6.
    Department of Pediatrics, Hospital Universitario Virgen del Rocío, Seville, Spain.
    Calcinosis cutis is a term used to describe a group of disorders in which calcium salt deposits form in the skin and subcutaneous tissue. We report a 6-year-old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia being treated with calcium gluconate intravenous infusion through peripheral veins. Within a few days we made a diagnosis of iatrogenic calcinosis cutis and treatment with 10% topical sodium thiosulfate was prescribed; complete resolution of lesions was achieved after 6 months, with no local or systemic adverse effects. Read More

    Anetodermic pilomatricoma: clinical, histopathologic, and sonographic findings.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Hospital Universitario de Cabueñes, Servicio de Dermatología, Gijón, Asturias, España.
    Pilomatricoma is a benign cutaneous tumor originatingfrom hair matrix cells. Anetodermic changes inthe skin overlying pilomatricomas are sometimesreported, although their precise mechanisms remainunknown. We present an unusual case of anetodermicpilomatricoma on the upper extremity of a 17-yearoldboy and report its clinical, histopathologic, andsonographic findings. Read More

    Presentation of calcinosis cutis universalis in mixed connective tissue disorder: an encounter during hip arthroplasty.
    BMJ Case Rep 2017 Mar 13;2017. Epub 2017 Mar 13.
    Department of Orthopedics, KG Hospital, Coimbatore, Tamil Nadu, India.
    A woman aged 23 years with a diagnosis of mixed connective tissue disorder presented with left groin pain extending over 6 months. Workup revealed avascular necrosis of the femoral head (Grade 3) secondary to systemic lupus erythematosus and chronic steroid intake. An uncemented total hip arthroplasty was considered as the patient was only in the third decade of life. Read More

    Calciphylaxis: Comparison of radiologic imaging and histopathology.
    J Am Acad Dermatol 2017 Aug 9;77(2):241-246.e3. Epub 2017 Mar 9.
    Department of Department of Hyperbaric Medicine and Wound Healing, Greenwich Hospital, Greenwich, Connecticut.
    Background: The current gold standard for diagnosis of calciphylaxis is a skin biopsy specimen demonstrating calcification of small-caliber arteries or arterioles.

    Objective: The aim of this study is to compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis.

    Methods: We conducted a retrospective study of patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images taken as part of their routine care. Read More

    Clinical utility of hypo- and hyperpigmentation of skin in diffuse cutaneous systemic sclerosis.
    Int J Rheum Dis 2017 Jun 6;20(6):767-773. Epub 2017 Mar 6.
    Rheumatology Department, Waikato Hospital, Hamilton, New Zealand.
    Aim: Cutaneous involvement is an early manifestation of systemic sclerosis (SSc). Localized areas of 'salt and pepper skin' (S&P) may develop. We hypothesize that S&P skin occurs frequently in diffuse cutaneous (dc) SSc which can be used in its early diagnosis and may correlate with joint contractures. Read More

    Benign Miliary Osteoma Cutis of the Face: A Common Incidental CT Finding.
    AJNR Am J Neuroradiol 2017 Apr 23;38(4):789-794. Epub 2017 Feb 23.
    From the Department of Radiology (D.K., P.H.), Lahey Hospital and Medical Center, Burlington, Massachusetts
    Background And Purpose: Osteoma cutis of the face represents a primary or secondary formation of ossific foci in the facial skin. Its primary form has been sparsely described in the plastic surgery and dermatology literature. As radiologists, we routinely encounter incidental, very small facial calcified nodules on CT studies performed for a variety of unrelated reasons. Read More

    Relationship between calcium channel blockers and skin fibrosis in patients with systemic sclerosis.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):56-60. Epub 2017 Jan 31.
    St. Joseph's Healthcare Hamilton, ON; and Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
    Objectives: Recent experimental evidence suggests that calcium channel blockers (CCBs) may have anti-fibrotic effects on liver and pulmonary fibrosis. We aimed to investigate whether use of CCBs was associated with the skin fibrosis in patients with systemic sclerosis (SSc).

    Methods: Based on the 5-year follow-up data from the Canadian Scleroderma Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin fibrosis measured by the modified Rodnan skin score (mRSS). Read More

    Unilateral Idiopathic Calcinosis Cutis: A Case Report.
    Case Rep Dermatol 2017 Jan-Apr;9(1):20-24. Epub 2017 Jan 27.
    Department of Dermatology, King Saud Medical City, Riyadh, Saudi Arabia.
    Calcinosis cutis is a rare disorder characterized by the deposition of calcium in the skin and subcutaneous tissue. Unilateral idiopathic calcinosis cutis has only rarely been reported in the literature. Here, we report the case of a 7-year-old healthy girl who presented with multiple asymptomatic hard nodules on the right side of her body. Read More

    Juvenile dermatomyositis in a 4-year-old Kenyan girl.
    Clin Case Rep 2017 Feb 17;5(2):134-138. Epub 2017 Jan 17.
    Department of Internal Medicine Kilimanjaro Christian Medical Centre Moshi United Republic of Tanzania.
    To our knowledge, this is the first case report of juvenile dermatomyositis (JDM) in Tanzania. It demonstrates that the characteristic cutaneous findings of JDM may easily be overlooked, especially on dark skin, and the difficulty of clinical management in resource-constrained settings. Read More

    The family impact of caring for a child with juvenile dermatomyositis.
    Chronic Illn 2017 Dec 30;13(4):262-274. Epub 2017 Jan 30.
    Pacific Graduate School of Psychology, Palo Alto University, Palo Alto, CA, USA.
    Background Juvenile dermatomyositis (JDM), a rare autoimmune disease, accounts for more than 80% of idiopathic inflammatory myopathy childhood cases, making it the most common idiopathic inflammatory myopathy among children. The average age of onset is approximately 7 years and commonly leads a chronic course. Symptoms of JDM include cutaneous features (Gottron's rash, heliotrope rash, or nail fold capillary changes), musculoskeletal features, calcinosis and lipodystrophy (a symmetrical deficit of subcutaneous fatty tissue), and acanthosis (thickening of the skin). Read More

    Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
    Arthritis Care Res (Hoboken) 2017 Jan 27. Epub 2017 Jan 27.
    Stanford University School of Medicine, Stanford, California.
    Objective: To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti-NXP-2) antibodies.

    Methods: We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Read More

    Calcinosis Cutis Circumscripta Of Knee-A Rare Presentation.
    J Orthop Case Rep 2016 Jul-Aug;6(3):78-79
    Department of Orthopaedics, ACPM Medical College, Dhule-424001, Maharashtra, India.
    Introduction: Calcinosis circumscripta is a form of ectopic mineralization characterized by single or multiple cutaneous nodules containing calcium salts. Calcinosis cutis circumscripta is a very rare form of idiopathic calcinosis cutis arising in the second half oflife. It typically involves the extremities and is associated with prior trauma and scleroderma. Read More

    Antinuclear Matrix Protein 2 Autoantibodies and Edema, Muscle Disease, and Malignancy Risk in Dermatomyositis Patients.
    Arthritis Care Res (Hoboken) 2017 Nov;69(11):1771-1776
    Johns Hopkins University School of Medicine, Baltimore, Maryland, and National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
    Objective: Dermatomyositis (DM) patients typically present with proximal weakness and autoantibodies that are associated with distinct clinical phenotypes. We observed that DM patients with autoantibodies recognizing the nuclear matrix protein NXP-2 often presented with especially severe weakness. The aim of this study was to characterize the clinical features associated with anti-NXP-2 autoantibodies. Read More

    Juvenile dermatomyositis: a tertiary center experience.
    Clin Rheumatol 2017 Feb 5;36(2):361-366. Epub 2017 Jan 5.
    Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
    Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of patients with JDM at a referral pediatric rheumatology center in Turkey. Read More

    [Advanced Systemic Sclerosis: Endovascular Reconstruction of the Aortic Bifurcation for Limb Salvage].
    Dtsch Med Wochenschr 2017 Jan 5;142(1):43-46. Epub 2017 Jan 5.
    Zentrum für Radiologie, Bergisches Gefäßzentrum, HELIOS Universitätsklinikum Wuppertal, Universität Witten/Herdecke.
    History and admission findings A 69-year-old patient was initially hospitalized because of a 1.5 cm ulceration at the back of the right foot which had existed for the last year and become increasingly swollen and painful. Medical history revealed PmScl-positive systemic sclerosis presenting with a massive calcinosis cutis, advanced pulmonary fibrosis and peripheral artery disease. Read More

    Rothmund-Thomson syndrome and osteoma cutis in a patient previously diagnosed as COPS syndrome.
    Eur J Pediatr 2017 Feb 30;176(2):279-283. Epub 2016 Dec 30.
    Department of Clinical genetics, Leiden University Medical Centre, Postzone K5-R, PO box 9600, 2300 RC, Leiden, The Netherlands.
    We present a patient with poikiloderma, severe osteoporosis and a mild intellectual disability. At the age of 9 years, this patient was proposed to suffer from a novel disease entity designated as calcinosis cutis, osteoma cutis, poikiloderma and skeletal abnormalities (COPS) syndrome. At the age of 35, he was diagnosed with Hodgkin's lymphoma. Read More

    Hand Impairment in Systemic Sclerosis: Various Manifestations and Currently Available Treatment.
    Curr Treatm Opt Rheumatol 2016 Sep 19;2(3):252-269. Epub 2016 Jul 19.
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; University of Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Systemic sclerosis (SSc) is an autoimmune disease initially recognized by hand involvement due to characteristic Raynaud's phenomenon (RP), puffy hands, skin thickening, and contractures resembling claw deformities. SSc contributes to hand impairment through inflammatory arthritis, joint contractures, tendon friction rubs (TFRs), RP, digital ulcers (DU), puffy hands, skin sclerosis, acro-osteolysis, and calcinosis. These manifestations, which often co-exist, can contribute to difficulty with occupational activities and activities of daily living (ADL), which can result in impaired quality of life. Read More

    Nail involvement in systemic sclerosis.
    J Am Acad Dermatol 2017 Jun 20;76(6):1115-1123. Epub 2016 Dec 20.
    Department of Internal Medicine, Rouen University Hospital, Rouen, France; Institut National de la Santé et de la Recherche Médicale U 905, University of Rouen Institut Fédératif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France.
    Background: Nail involvement has rarely been recognized in systemic sclerosis (SSc). Indeed, only a few small series have assessed nail changes in SSc, most of which are case reports.

    Objective: The aims of the current case-control study were to: (1) determine the prevalence of fingernail changes in SSc; and (2) evaluate the correlation between fingernail changes and other features of SSc. Read More

    Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.
    Genet Mol Res 2016 Dec 19;15(4). Epub 2016 Dec 19.
    Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde, Universidade Luterana do Brasil, Canoas, RS, Brasil
    The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and degradation. Read More

    Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases.
    Joint Bone Spine 2017 May 7;84(3):341-344. Epub 2016 Dec 7.
    Pôle locomoteur, service de rhumatologie, centre Viggo Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris 7 Denis Diderot, Paris Cité Sorbonne, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:
    Intravenous sodium thiosulfate (ivSTS) is a promising new therapeutic option for calciphylaxis related to end-stage renal disease. However, its effect on tumoral calcinosis (TC) complicating autoimmune connective-tissue diseases has been scarcely described. We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. Read More

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