2,874 results match your criteria Calcinosis Cutis


Treatment of calcinosis cutis with sodium thiosulfate therapy.

J Am Acad Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Mass General Hospital of Harvard Medical School, 50 Staniford Street, Suite 200, Boston, MA 02114.

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http://dx.doi.org/10.1016/j.jaad.2020.06.996DOI Listing

Cutaneous Sarcoidosis.

Semin Respir Crit Care Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Sarcoidosis is a chronic, multisystem, inflammatory disorder of unknown etiology that is characterized by noncaseating granulomas that impair normal organ functioning. Sarcoidosis predominantly affects the lungs, but the skin is often cited as the second most frequently involved organ. Cutaneous manifestations of sarcoidosis are highly variable and ongoing research seeks to better understand the relationship between clinical morphology and disease prognosis. Read More

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http://dx.doi.org/10.1055/s-0040-1713130DOI Listing

Abatacept in the Treatment of Juvenile Dermatomyositis-Associated Calcifications in a 16-Year-Old Girl.

Case Rep Rheumatol 2020 28;2020:4073879. Epub 2020 May 28.

Division of Infectious Diseases, Department of Pediatrics, Valley Children's Hospital, Madera, CA, USA.

Calcinosis is a feared complication of JDM that may be seen in up to 40% of children with JDM. It is associated with negative impact on the patients' quality of life due to weakness, functional disability, joint contractures, muscle atrophy, skin ulcers, and secondary infections. Calcinosis can present as superficial nodules or plaques, larger nodular deposits extending into deeper tissue layers, accumulation of calcifications along the fascial planes of muscles or tendons, or an exoskeleton of calcium leading to limitations in mobility and joint contractures. Read More

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http://dx.doi.org/10.1155/2020/4073879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275234PMC

[Juvenile dermatomyositis: A series of 22 cases].

Authors:
C Moegle D Lipsker

Ann Dermatol Venereol 2020 Jun 9. Epub 2020 Jun 9.

Service de dermatologie, hôpital universitaire de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:

Purpose: To report on the characteristics of juvenile dermatomyositis (JDM).

Patients And Methods: This was a retrospective, descriptive, cross-sectional, non-interventional, multicenter study conducted in Alsace between 2000 and 2015. The patients, aged 0 to 16years, had JDM according to both the Bohan and Peter and the EULAR/ACR criteria. Read More

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http://dx.doi.org/10.1016/j.annder.2020.04.016DOI Listing

Calciphylaxis in the Setting of Hemodialysis, Liver Cirrhosis, and Warfarin Therapy for Atrial Fibrillation: An Argument for Alternative Anti-Embolic Therapy.

Cureus 2020 May 7;12(5):e8014. Epub 2020 May 7.

Division of Nephrology, Hypertension, and Transplant, Augusta University Medical College of Georgia, Augusta, USA.

Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare, life-threatening cutaneous systemic disease that typically occurs in the setting of end-stage renal disease (ESRD). ESRD is the most recognized risk factor for calciphylaxis but it is not the sole risk factor. Calciphylaxis has also been associated with liver cirrhosis with or without concurrent renal disease. Read More

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http://dx.doi.org/10.7759/cureus.8014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279680PMC

A Case of Dermatomyositis Coexisting with Both Anti-Mi-2 and Anti-NXP-2 Antibodies.

Case Rep Dermatol 2020 May-Aug;12(2):92-97. Epub 2020 May 5.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Myositis-specific autoantibodies (MSAs) including anti-Mi-2 and anti-nuclear matrix protein 2 (NXP-2) antibodies have been detected in the patients with dermatomyositis (DM), and are useful tools for identifying clinical subsets of DM. MSAs are exclusively found in DM patients. Anti-Mi-2 antibody-positive DM patients show the typical skin lesions and myositis and are rarely associated with internal malignancy and interstitial lung disease (ILD). Read More

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http://dx.doi.org/10.1159/000507504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250387PMC

Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases.

Neurology 2020 Jun 2. Epub 2020 Jun 2.

From the Departments of Clinical Immunology and Internal Medicine (Y.A., S.T., G.L., B.H., N.C., K.M., O.B.), Immunobiology (M.M.), and Biostatistics, Public Health, and Medical Information (B.G.), Pitié-Salpêtrière Hospital, APHP, Sorbonne Universities; Myology Research Centre (Y.A., O.B.), INSERM, UMRS 974, Paris; Department of Pneumology (Y.U., H.N.), APHP, Avicenne Hospital, INSERM U1272, Université Sorbonne Paris Nord, Bobigny; Department of Internal Medicine (L.G., A. Marquet), Lyon Sud Hospital, Lyon Sud University, Paris; Reference Centre for Rare Autoimmune Diseases (A. Meyer) and Medical Intensive Care Unit, Hautepierre Hospital (V. Castelain), Hôpitaux Universitaires de Strasbourg, Strasbourg University; Division of Pneumology (R.B.), Bichat Hospital, AP-HP, Paris-Diderot University, Paris; Department of Pneumology (F.G., P.P.), Centre Hospitalier Universitaire, Angers University; Department of Internal Medicine Infectieuses (C.D.), CHU de Martinique, Fort de France; Departments of Internal Medicine and Clinical Immunology (S.A.) and Internal Medicine and Systemic Diseases (H.D.), François-Mitterrand University Hospital, University of Bourgogne-Franche-Comté, Dijon; Internal Medicine Department (B.T., A.B.), Cochin Hospital, AP-HP, René Descartes University, Paris; Department of Internal Medicine (C.G., N.L.), Henri Mondor Hospital, Paris Est Créteil University, Créteil, France; Department of Neurology (N.V.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Internal Medicine (E.D.), Hôpital Bretonneau Tours, Tours University; Internal Medicine Department (A.S.), Hôpital Robert-Debré, Reims University; Departments of Rheumatology (T.M.) and Internal Medicine (L.D.S.M.), Bretagne Occidentale University, Centre Hospitalo-Universitaire de Brest; Department of Internal Medicine (S.H.), CHU de Besançon; Department of Internal Medicine (C.B.-D.), Centre Hospitalier Général de Niort; Department of Internal Medicine (N.T.), Nice University, CHU Nice; Department of Internal Medicine (P.C.), Institut Mutualiste Montsouris, Paris; Department of Internal Medicine (M.G.), Jean Verdier Hospital, Paris Seine-Saint-Denis University, Bondy; Department of Internal Medicine (A. Mekinian), Saint Antoine Hospital, APHP, Sorbonne Universities, Paris; Department of Pneumology CHU (J.C.M.), Poitiers University; Department of Pneumology (A.T.), Hôpital Saint-Louis, APHP, Sorbonne Paris Cité, University Paris-Diderot, Paris; Department of Respiratory Medicine (V. Cottin), National Reference Center for Rare Pulmonary Diseases, Hospices Civils de Lyon, Claude Bernard University Lyon 1, Lyon University; Department of Pneumology (D.I.-B.), European George Pompidou Hospital, APHP, Paris V University; Department of Pneumology (S.P.-H.), Sainte-Camille Hospital, Bry-sur-Marne; Department of Pneumology (C.B.), Foch Hospital, Saint Quentin en Yveline University, Suresnes; and Department of Immunology (N.F.), Lyon-Sud Hospital, Hospices Civils-de-Lyon, Pierre-Bénite, France.

Objectives: The predominance of extramuscular manifestations (e.g., skin rash, arthralgia, interstitial lung disease [ILD]) as well as the low frequency of muscle signs in anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis caused us to question the term myositis-specific antibody for the anti-MDA5 antibody, as well as the homogeneity of the disease. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009727DOI Listing

Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients?

Ren Fail 2020 Nov;42(1):483-488

Nephrology Department, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

The coronavirus disease-19 (COVID-19) has spread over many countries and regions since the end of 2019, becoming the most severe public health event at present. Most of the critical cases developed multiple organ dysfunction, including acute kidney injury (AKI). Cytokine storm syndrome (CSS) may complicate the process of severe COVID-19 patients. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1764369DOI Listing
November 2020

Milia-Like Idiopathic Calcinosis Cutis: When Waiting Is the Best Option.

J Pediatr 2020 May 8. Epub 2020 May 8.

Azienda USL Toscana Nord Ovest, UOS Dermatologia di Lucca, Lucca, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.05.003DOI Listing

MR imaging findings of calcinosis cutis in primary Sjogren syndrome, a rare manifestation.

Radiol Case Rep 2020 Jul 15;15(7):1029-1038. Epub 2020 May 15.

Department of Surgery, UF Health Jacksonville, Jacksonville, FL 32209, USA.

Soft tissue calcifications associated with various connective tissue diseases such as dermatomyositis and scleroderma have been well documented Plaque-like sheets of subcutaneous calcifications presenting as an indurated soft tissue mass in a patient with primary Sjogren syndrome have been rarely documented in the literature. We present the magnetic resonance and conventional radiographic findings of calcinosis cutis and calcinosis circumscripta of a 47-year-old woman with biopsy proven Sjogren syndrome. We also delineate various types of soft tissue calcification, histopathology of calcinosis cutis, and current treatment options. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229417PMC

Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease.

JAMA Dermatol 2020 May 20. Epub 2020 May 20.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamadermatol.2020.1157DOI Listing

Cytokine storm syndrome in severe COVID-19.

Autoimmun Rev 2020 07 3;19(7):102562. Epub 2020 May 3.

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

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http://dx.doi.org/10.1016/j.autrev.2020.102562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252135PMC

A 52-Year-Old Female with Multiple Swellings in Both Hands: Idiopathic Calcinosis Cutis.

Cureus 2020 Mar 30;12(3):e7471. Epub 2020 Mar 30.

Medicine, All India Institute of Medical Sciences, Jodhpur, IND.

Calcinosis cutis is a rare disorder characterized by deposition of insoluble calcium salts in skin and subcutaneous tissue. Depending upon the aetiology, there are five subtypes of calcinosis cutis described in the literature; dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Idiopathic calcinosis cutis is rarely described in the literature. Read More

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http://dx.doi.org/10.7759/cureus.7471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188000PMC

'Narrow-sense' and 'broad-sense' vascular abnormalities of systemic sclerosis.

Authors:
Masatoshi Jinnin

Immunol Med 2020 Apr 23:1-8. Epub 2020 Apr 23.

Department of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan.

Systemic sclerosis (SSc) induces skin thickening and numerous symptoms involving the entire body. Collagen deposition, immune disorder, and vascular abnormalities is currently estimated to be three major causal factors involved in the respective conditions. Vascular abnormalities usually develop in the initial phase of this disease, and may exist in all phases; therefore, they markedly influence the patient's quality of life. Read More

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http://dx.doi.org/10.1080/25785826.2020.1754692DOI Listing

Subcutaneous granuloma annulare mimicking dermatomyositis.

Pediatr Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

We present three children who presented with papules and plaques over the knuckles, mimicking Gottron's papules of juvenile dermatomyositis, as well as subcutaneous nodules over the joints of the extremities that were initially thought to represent calcinosis cutis. However, thorough clinical and laboratory evaluation, as well as imaging, failed to support this diagnosis. Skin biopsies were consistent with a diagnosis of subcutaneous granuloma annulare. Read More

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http://dx.doi.org/10.1111/pde.14167DOI Listing

Retrospective analysis of infliximab and adalimumab treatment in a large cohort of juvenile dermatomyositis patients.

Arthritis Res Ther 2020 04 15;22(1):79. Epub 2020 Apr 15.

Rheumatology Section, Great Ormond Street Hospital for Children NHS Trust, Level 6 Southwood Building, Great Ormond Street, London, WC1N 3JH, UK.

Background: Anti-TNF treatment may be useful for the treatment of patients with refractory juvenile dermatomyositis (JDM). The aim of this study was to describe the use of infliximab and adalimumab therapy in juvenile dermatomyositis as an adjunctive treatment.

Methods: Sixty children recruited to the UK JDM Cohort and Biomarker Study that had received at least 3 months of anti-TNF treatment (infliximab or adalimumab) were studied. Read More

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http://dx.doi.org/10.1186/s13075-020-02164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161150PMC

Clinical and sonographic features of nipple lesions.

Medicine (Baltimore) 2020 Apr;99(15):e19728

Department of Medical Ultrasound.

Background: The aim of this study was to present several cases of benign and malignant nipple lesions and contribute to diagnosis and differential diagnosis.

Methods: A retrospective study was conducted on 13 patients. All of the patients were evaluated by ultrasonography, and 11 of them had pathological results. Read More

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http://dx.doi.org/10.1097/MD.0000000000019728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220069PMC

Pathogenic Activation of Mesenchymal Stem Cells is induced by the Disease Microenvironment in Systemic Sclerosis.

Arthritis Rheumatol 2020 Mar 31. Epub 2020 Mar 31.

UCL Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital Campus, University College London Medical School, Rowland Hill Street, London, NW3 2PF, UK.

Objective: In systemic sclerosis (SSc) a persistent tissue repair process leads to progressive fibrosis of the skin and internal organs. The role of mesenchymal stem cells (MSCs), which characteristically initiate and regulate tissue repair, has not been fully evaluated. We sought to investigate whether dividing metakaryotic MSCs are present in SSc skin, and test whether exposure to the disease microenvironment activates MSCs leading to transdifferentation. Read More

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http://dx.doi.org/10.1002/art.41267DOI Listing

Calcinosis Biomarkers in Adult and Juvenile Dermatomyositis.

Autoimmun Rev 2020 Jun 28;19(6):102533. Epub 2020 Mar 28.

Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address:

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by muscle weakness and cutaneous manifestations in adults and children. Calcinosis, a complication of DM, is the abnormal deposition of insoluble calcium salts in tissues, including skin, subcutaneous tissue, tendons, fascia, and muscle. Calcinosis is more commonly seen in juvenile DM (JDM), but also develops in adult DM. Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225028PMC

[comIdiopathic scrotal calcinosis: A report of 10 cases and review of the literature].

Zhonghua Nan Ke Xue 2019 Jun;25(6):544-548

Department of Urology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Objective: To investigate the clinical features, pathogenesis, diagnosis and scrotal reconstruction in the treatment of idiopathic scrotal calcinosis (ISC).

Methods: From March 2007 to October 2018, 10 ISC patients, aged 28-79 (mean 45) years and with a disease course of 6-497 (mean 128.4) months, were treated in our hospital. Read More

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Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions.

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

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http://dx.doi.org/10.7759/cureus.6955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067514PMC
February 2020

Calcinosis Cutis Associated with Chronic Sclerodermoid Graft versus Host Disease: A Case and Review of the Literature.

Case Rep Dermatol Med 2020 27;2020:9250923. Epub 2020 Feb 27.

Department of Dermatology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

We present a rare case of calcinosis cutis associated with chronic sclerodermoid graft versus host disease in a 59-year-old male, 13 years following allogenic bone marrow transplantation. The etiology of calcification was thought to be dystrophic. Further research is needed to understand the link between calcinosis cutis and chronic sclerodermoid graft versus host disease to assist with selecting appropriate management for these patients. Read More

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http://dx.doi.org/10.1155/2020/9250923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064823PMC
February 2020

Epidemiology and Treatment of Calcinosis Cutis: 13 Years of Experience.

Indian J Dermatol 2020 Mar-Apr;65(2):105-111

Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Background: Calcinosis cutis is a rare condition associated with different diseases, which is difficult to manage.

Aims And Objectives: In this retrospective study, the epidemiology of calcinosis cutis and the effectiveness of various treatment regimens in its management were assessed in a single center.

Materials And Methods: The data of 34 patients suffering from calcinosis cutis (male:female = 12:22; mean age = 48. Read More

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http://dx.doi.org/10.4103/ijd.IJD_527_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059479PMC

Calcinosis Cutis.

Am J Med 2020 Mar 9. Epub 2020 Mar 9.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Japan.

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http://dx.doi.org/10.1016/j.amjmed.2020.01.040DOI Listing

Calcinosis cutis.

Authors:
S Mumtaz V Sharma

Br J Oral Maxillofac Surg 2020 May 4;58(4):491-492. Epub 2020 Mar 4.

Department of Oral and Maxillofacial Surgery, Royal Free London NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.bjoms.2019.10.324DOI Listing

Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil.

Turk J Pediatr 2019 ;61(5):771-775

Clinic of Pediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, İstanbul, Turkey.

Çakan M, Karadağ ŞG, Aktay Ayaz N. Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil. Turk J Pediatr 2019; 61: 771-775. Read More

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http://dx.doi.org/10.24953/turkjped.2019.05.018DOI Listing
January 2019

Old and rare complication of dermatomyositis: calcinosis cutis.

BMJ Case Rep 2020 Feb 20;13(2). Epub 2020 Feb 20.

Medicina Interna 2, Hospital do Espirito Santo EPE, Evora, Portugal.

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http://dx.doi.org/10.1136/bcr-2019-233988DOI Listing
February 2020

Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity.

PLoS One 2020 19;15(2):e0228503. Epub 2020 Feb 19.

Helmholtz Institute for Biomedical Engineering, Biointerface Lab, RWTH Aachen University Hospital, Aachen, Germany.

The plasma protein fetuin-A mediates the formation of protein-mineral colloids known as calciprotein particles (CPP)-rapid clearance of these CPP by the reticuloendothelial system prevents errant mineral precipitation and therefore pathological mineralization (calcification). The mutant mouse strain D2,Ahsg-/- combines fetuin-A deficiency with the calcification-prone DBA/2 genetic background, having a particularly severe compound phenotype of microvascular and soft tissue calcification. Here we studied mechanisms leading to soft tissue calcification, organ damage and death in these mice. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029858PMC

Idiopathic calcinosis cutis in a young male: A cytological diagnosis with histopathological correlation.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):140-141

Department of Lab Medicine, Max Lab, Max Super Speciality Hospital, 1 Press Enclave Road, Saket, New Delhi, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_206_19DOI Listing
February 2020

Ectopic Cushing's syndrome associated with a pheochromocytoma in a dog: a case report.

BMC Vet Res 2020 Feb 3;16(1):35. Epub 2020 Feb 3.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.

Background: Ectopic Cushing's syndrome (ECS) associated with malignant tumors, such as small cell lung carcinoma, bronchial carcinoids, and pheochromocytoma, has been reported in human medicine. However, ECS related to pheochromocytoma has not been reported in dogs.

Case Presentation: An 11-year-old castrated, male Scottish terrier was diagnosed with a left adrenal mass. Read More

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http://dx.doi.org/10.1186/s12917-020-2244-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998063PMC
February 2020

Calcinosis cutis universalis.

QJM 2020 Jan 30. Epub 2020 Jan 30.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/qjmed/hcaa017DOI Listing
January 2020

Characterizing calcinosis cutis in a pediatric population.

Pediatr Dermatol 2020 Mar 28;37(2):317-319. Epub 2020 Jan 28.

Department of Dermatology (Pediatric Dermatology) and Pediatrics, Medical College of Wisconsin, Milwaukee, WI.

Background/objectives: Calcinosis cutis is the abnormal deposition of calcium in the skin and subcutis. There is currently a paucity of data surrounding pediatric calcinosis cutis. The objective of this study is to characterize calcinosis cutis in a pediatric cohort. Read More

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http://dx.doi.org/10.1111/pde.14103DOI Listing

Calcinosis Cutis as the Initial Manifestation of Limited Scleroderma.

J Clin Rheumatol 2020 Jan 24. Epub 2020 Jan 24.

Division of Rheumatology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/RHU.0000000000001275DOI Listing
January 2020

Patient and physician discordance of global disease assessment in juvenile dermatomyositis: findings from the Childhood Arthritis & Rheumatology Research Alliance Legacy Registry.

Pediatr Rheumatol Online J 2020 Jan 15;18(1). Epub 2020 Jan 15.

Pediatric Rheumatology, Benioff Children's Hospital and University of San Francisco Medical Center, San Francisco, CA, USA.

Background: Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF and MD global activity scores in juvenile dermatomyositis (JDM), and determine factors associated with discordance.

Methods: Patients with JDM were included from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry (N = 563). Read More

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http://dx.doi.org/10.1186/s12969-020-0402-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964044PMC
January 2020

Pamidronate in Treatment of Calcinosis in Juvenile Dermatomyositis.

Indian Pediatr 2020 01;57(1):75-76

Department of Skin and VD, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

Juvenile dermatomyositis is a rare systemic autoimmune disease wth calcinosis as its hallmark sequelae. We report three patients with juvenile dermatomyositis with calcinosis, who were treated with pamidronate. There was complete clearance of calcinosis in one child. Read More

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January 2020

[AT THE BOTTOM OF THE ULCER - THE IMPORTANCE OF A BIOPSY IN DIAGNOSING HARD TO TREAT ULCERS].

Harefuah 2020 Jan;159(1):21-24

Department of Dermatology, Rambam Health Care Campus, Haifa.

Introduction: We report a case of a patient who presented with bilateral chronic painful necrotic leg ulcers. A skin biopsy revealed histopathological findings compatible with calciphylaxis, a rare phenomenon accompanied by high morbidity and mortality. Treatment options are limited and are based mainly on case reports and small series, so further research is needed in this area. Read More

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January 2020

Idiopathic Scrotal Calcinosis: A Case Report of a Rare Entity.

Case Rep Urol 2019 16;2019:6501964. Epub 2019 Dec 16.

Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Scrotal calcinosis is a benign condition where multiple calcified nodules are found within the dermis of the scrotal skin. It is a rare condition which is usually asymptomatic and has no clear aetiology although several theories have been proposed in the aetiopathogenesis. We report a 55-year-old man with extensive scrotal calcinosis. Read More

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http://dx.doi.org/10.1155/2019/6501964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939430PMC
December 2019

Favorable outcome of pheochromocytoma in a dog with atypical Cushing's syndrome and diabetes mellitus following medical treatment: a case report.

BMC Vet Res 2020 Jan 3;16(1). Epub 2020 Jan 3.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, # 1 Hwayang-dong, Gwang-jin-gu, Seoul, 143-701, South Korea.

Background: Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs.

Case Presentation: A 14-year-old castrated male Poodle dog presented with an abdominal mass. Read More

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http://dx.doi.org/10.1186/s12917-019-2225-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942262PMC
January 2020

The color of skin: purple diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):528-547. Epub 2019 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vessel vasculitis, immunoglobulin A (IgA) vasculitis, cryoglobulinemia, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosum, warfarin-induced skin necrosis, heparin-induced thrombocytopenia, purpura fulminans, antiphospholipid antibody syndrome, calciphylaxis, levamisole-induced vasculopathy, and thrombotic thrombocytopenic purpura. Dermatologists play a central role in treating patients with cutaneous vasculitis and vasculopathy and may have the opportunity to facilitate identification of systemic disease by diagnosing cutaneous vasculitis and vasculopathy. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.016DOI Listing

The color of skin: black diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):447-467. Epub 2019 Aug 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Gradations in skin color are a consequence of differing amounts of melanin and their varying distribution. Although many darkly pigmented skin lesions are melanocytic and can be attributed to melanin content, the color of a black lesion can also be due to blood, necrotic tissue, or exogenous pigment. The source, pattern, and distribution of the color in black lesions usually offer important insight into its etiology. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.08.003DOI Listing

Use of Neem oil and for treatment of calcinosis-related skin ulcers in systemic sclerosis.

J Int Med Res 2019 Dec 25:300060519882176. Epub 2019 Dec 25.

Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

Objective: This study evaluated Neem oil and (Holoil®) for treatment of scleroderma skin ulcers related to calcinosis (SU-calc). We retrospectively analyzed 21 consecutive systemic sclerosis (SSc) patients with a total of 33 SU-calcs treated daily with Holoil® cream compared with a control group of 20 patients with 26 SU-calcs. Holoil® was directly applied to skin lesions, while the control group received only standard medication. Read More

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http://dx.doi.org/10.1177/0300060519882176DOI Listing
December 2019

Pseudoxanthoma Elasticum, Kidney Stones and Pyrophosphate: From a Rare Disease to Urolithiasis and Vascular Calcifications.

Int J Mol Sci 2019 Dec 17;20(24). Epub 2019 Dec 17.

UMR S 1155 and Physiology Unit, AP-HP, Hôpital Tenon, Sorbonne Université and INSERM, F-75020 Paris, France.

Pseudoxanthoma elasticum is a rare disease mainly due to gene mutations and characterized by ectopic biomineralization and fragmentation of elastic fibers resulting in skin, cardiovascular and retinal calcifications. It has been recently described that pyrophosphate (a calcification inhibitor) deficiency could be the main cause of ectopic calcifications in this disease and in other genetic disorders associated to mutations of or . Patients affected by Pseudoxanthoma Elasticum seem also prone to develop kidney stones originating from papillary calcifications named Randall's plaque, and to a lesser extent may be affected by nephrocalcinosis. Read More

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http://dx.doi.org/10.3390/ijms20246353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940945PMC
December 2019

Subcutaneous fat necrosis of the newborn.

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Neonatology, Rotunda Hospital, Dublin, Ireland.

A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. Read More

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http://dx.doi.org/10.1136/bcr-2019-231458DOI Listing
December 2019

Delayed septic radiation-induced calcinosis cutis long after cured anorectal cancer.

Int J Colorectal Dis 2020 Feb 10;35(2):333-336. Epub 2019 Dec 10.

Oncologie-Radiothérapie-Radiopathologie, Groupe Hospitalier Universitaire, APHP site Saint-Louis, Université de Paris, 1 ave Claude Vellefaux, 75010, Paris, France.

Purpose: Calcinosis cutis is an anecdotal local injury seen long after irradiation in cancer survivors. Our purpose was to shed light on this little studied and potentially serious ulceration.

Cases: We report two cases of severe perineal-sacral infection with hard lesions, one decade after anorectal cancer irradiation. Read More

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http://dx.doi.org/10.1007/s00384-019-03467-zDOI Listing
February 2020

Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge.

BMJ Case Rep 2019 Dec 5;12(12). Epub 2019 Dec 5.

Plastic and Reconstructive Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Penile calciphylaxis is a rare but clinically challenging condition to manage. While multiple treatment options have been proposed, the underlying evidence is anecdotal, and the overall prognosis remains extremely poor. We describe the case of a patient who underwent urgent debridement of a suspected gangrenous penile tip, who was intraoperatively found to have penile calciphylaxis. Read More

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http://dx.doi.org/10.1136/bcr-2019-232138DOI Listing
December 2019

Long-term outcome in children with juvenile dermatomyositis: A single-center study from north India.

Int J Rheum Dis 2020 Mar 3;23(3):392-396. Epub 2019 Dec 3.

Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Juvenile dermatomyositis (JDM) is the commonest childhood inflammatory myopathy. Outcome of children with JDM has improved significantly with current treatment protocols. We undertook this study to evaluate long-term outcome of these children using validated outcome measures. Read More

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http://dx.doi.org/10.1111/1756-185X.13759DOI Listing

Milia-like idiopathic calcinosis cutis of the forehead in an adult without Down's syndrome successfully treated with a CO laser.

J Cosmet Dermatol 2020 Jan 29;19(1):102-104. Epub 2019 Nov 29.

Tennessee Clinical Research Center, Nashville, Tennessee.

Background: Idiopathic calcinosis cutis is an uncommon form of calcinosis cutis. It may present as tumoral calcinosis, subepidermal calcified nodules or scrotal calcinosis. Subepidermal calcified nodules may also present as milia-like lesions commonly seen in children with Down's syndrome in the absence of tissue damage or metabolic disorders, it has been seldom reported in adults. Read More

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http://dx.doi.org/10.1111/jocd.13233DOI Listing
January 2020
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