Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.

*Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX; †Department of Pathology, University of Colorado, Denver, CO; ‡Western Pathology, Inc., San Luis Obispo, CA; and §Loyola Stritch School of Medicine, Chicago, IL.

Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. Read More

Orthop Traumatol Surg Res 2017 May 30. Epub 2017 May 30.

Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Militaire Mohammed V, Rabat, Morocco.

Orthopedic surgeons are often consulted for diagnosis of MASS (mitral valve prolapse, aortic enlargement, skin and skeletal findings) syndrome, imaging showing periarticular calcification, or joint stiffness. Such presentations in a dialyzed patient should suggest tumoral calcinosis, which is a rare complication of dialysis, often diagnosed wrongly or late. It is often associated with calcium phosphate balance disorder, in which treatment is difficult and must take account of known contributing factors: severe hyperparathyroidism, increased phosphocalcic product, therapeutic calcium and vitamin D overload, and bone turnover slowed for varying reasons. Read More

JAMA Dermatol 2017 May 31. Epub 2017 May 31.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

Cureus 2017 Apr 8;9(4):e1145. Epub 2017 Apr 8.

Michigan Head and Spine Institute, Oakland University William Beaumont School of Medicine.

Calcinosis in CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome can affect the spinal and paraspinal areas. We present the first case to our knowledge where a CREST syndrome patient required surgery for spinal calcinosis in both the cervical and lumbar areas. A 66-year-old female with a history of CREST syndrome presented with right-sided lower extremity radicular pain. Read More

Ophthal Plast Reconstr Surg 2017 Apr 20. Epub 2017 Apr 20.

*Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, and †Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, U.S.A.

Purpose: To review the clinical and histopathologic findings associated with subepidermal calcinosis of the eyelids.

Methods: A systematic review of the literature on subepidermal calcinosis of the eyelids was performed. Cases included were idiopathic in nature and met the histologic criteria for subepidermal calcinosis with calcium deposits in the dermis of the skin. Read More

Pediatr Dermatol 2017 May 6;34(3):356-358. Epub 2017 Apr 6.

Department of Pediatrics, Hospital Universitario Virgen del Rocío, Seville, Spain.

Calcinosis cutis is a term used to describe a group of disorders in which calcium salt deposits form in the skin and subcutaneous tissue. We report a 6-year-old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia being treated with calcium gluconate intravenous infusion through peripheral veins. Within a few days we made a diagnosis of iatrogenic calcinosis cutis and treatment with 10% topical sodium thiosulfate was prescribed; complete resolution of lesions was achieved after 6 months, with no local or systemic adverse effects. Read More

Indian Pediatr 2017 Mar;54(3):253

Department of Pediatrics, AllMS, Jodhpur, Rajasthan, India.

BMJ Case Rep 2017 Mar 13;2017. Epub 2017 Mar 13.

Department of Orthopedics, KG Hospital, Coimbatore, Tamil Nadu, India.

A woman aged 23 years with a diagnosis of mixed connective tissue disorder presented with left groin pain extending over 6 months. Workup revealed avascular necrosis of the femoral head (Grade 3) secondary to systemic lupus erythematosus and chronic steroid intake. An uncemented total hip arthroplasty was considered as the patient was only in the third decade of life. Read More

Int J Rheum Dis 2017 Mar 6. Epub 2017 Mar 6.

Rheumatology Department, Waikato Hospital, Hamilton, New Zealand.

Aim: Cutaneous involvement is an early manifestation of systemic sclerosis (SSc). Localized areas of 'salt and pepper skin' (S&P) may develop. We hypothesize that S&P skin occurs frequently in diffuse cutaneous (dc) SSc which can be used in its early diagnosis and may correlate with joint contractures. Read More

Clin Exp Rheumatol 2017 Jan 31. Epub 2017 Jan 31.

St. Joseph's Healthcare Hamilton, ON; and Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Objectives: Recent experimental evidence suggests that calcium channel blockers (CCBs) may have anti-fibrotic effects on liver and pulmonary fibrosis. We aimed to investigate whether use of CCBs was associated with the skin fibrosis in patients with systemic sclerosis (SSc).

Methods: Based on the 5-year follow-up data from the Canadian Scleroderma Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin fibrosis measured by the modified Rodnan skin score (mRSS). Read More

Case Rep Dermatol 2017 Jan-Apr;9(1):20-24. Epub 2017 Jan 27.

Department of Dermatology, King Saud Medical City, Riyadh, Saudi Arabia.

Calcinosis cutis is a rare disorder characterized by the deposition of calcium in the skin and subcutaneous tissue. Unilateral idiopathic calcinosis cutis has only rarely been reported in the literature. Here, we report the case of a 7-year-old healthy girl who presented with multiple asymptomatic hard nodules on the right side of her body. Read More

Clin Case Rep 2017 Feb 17;5(2):134-138. Epub 2017 Jan 17.

Department of Internal Medicine Kilimanjaro Christian Medical Centre Moshi United Republic of Tanzania.

To our knowledge, this is the first case report of juvenile dermatomyositis (JDM) in Tanzania. It demonstrates that the characteristic cutaneous findings of JDM may easily be overlooked, especially on dark skin, and the difficulty of clinical management in resource-constrained settings. Read More

Chronic Illn 2017 Jan 1:1742395317690034. Epub 2017 Jan 1.

Pacific Graduate School of Psychology, Palo Alto University, Palo Alto, CA, USA.

Background Juvenile dermatomyositis (JDM), a rare autoimmune disease, accounts for more than 80% of idiopathic inflammatory myopathy childhood cases, making it the most common idiopathic inflammatory myopathy among children. The average age of onset is approximately 7 years and commonly leads a chronic course. Symptoms of JDM include cutaneous features (Gottron's rash, heliotrope rash, or nail fold capillary changes), musculoskeletal features, calcinosis and lipodystrophy (a symmetrical deficit of subcutaneous fatty tissue), and acanthosis (thickening of the skin). Read More

Arthritis Care Res (Hoboken) 2017 Jan 27. Epub 2017 Jan 27.

Department of Dermatology, Stanford University School of Medicine, Stanford, CA.

Objective: To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with anti-NXP-2 antibodies.

Methods: We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. Electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Read More

J Orthop Case Rep 2016 Jul-Aug;6(3):78-79

Department of Orthopaedics, ACPM Medical College, Dhule-424001, Maharashtra, India.

Introduction: Calcinosis circumscripta is a form of ectopic mineralization characterized by single or multiple cutaneous nodules containing calcium salts. Calcinosis cutis circumscripta is a very rare form of idiopathic calcinosis cutis arising in the second half oflife. It typically involves the extremities and is associated with prior trauma and scleroderma. Read More

Cutis 2016 Dec;98(6):E22-E23

Department of Dermatology, Faculty of Medicine, University of Harran, Turkey.

Arthritis Care Res (Hoboken) 2017 Jan 13. Epub 2017 Jan 13.

Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: Dermatomyositis (DM) patients typically present with proximal weakness and autoantibodies that are associated with distinct clinical phenotypes. We observed that DM patients with autoantibodies recognizing the nuclear matrix protein NXP-2 often presented with especially severe weakness. The aim of this study was to characterize clinical features associated with anti-NXP-2 autoantibodies. Read More

Clin Rheumatol 2017 Feb 5;36(2):361-366. Epub 2017 Jan 5.

Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of patients with JDM at a referral pediatric rheumatology center in Turkey. Read More

Dtsch Med Wochenschr 2017 Jan 5;142(1):43-46. Epub 2017 Jan 5.

Zentrum für Radiologie, Bergisches Gefäßzentrum, HELIOS Universitätsklinikum Wuppertal, Universität Witten/Herdecke.

History and admission findings A 69-year-old patient was initially hospitalized because of a 1.5 cm ulceration at the back of the right foot which had existed for the last year and become increasingly swollen and painful. Medical history revealed PmScl-positive systemic sclerosis presenting with a massive calcinosis cutis, advanced pulmonary fibrosis and peripheral artery disease. Read More

Eur J Pediatr 2017 Feb 30;176(2):279-283. Epub 2016 Dec 30.

Department of Clinical genetics, Leiden University Medical Centre, Postzone K5-R, PO box 9600, 2300 RC, Leiden, The Netherlands.

We present a patient with poikiloderma, severe osteoporosis and a mild intellectual disability. At the age of 9 years, this patient was proposed to suffer from a novel disease entity designated as calcinosis cutis, osteoma cutis, poikiloderma and skeletal abnormalities (COPS) syndrome. At the age of 35, he was diagnosed with Hodgkin's lymphoma. Read More

Curr Treatm Opt Rheumatol 2016 Sep 19;2(3):252-269. Epub 2016 Jul 19.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; University of Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Systemic sclerosis (SSc) is an autoimmune disease initially recognized by hand involvement due to characteristic Raynaud's phenomenon (RP), puffy hands, skin thickening, and contractures resembling claw deformities. SSc contributes to hand impairment through inflammatory arthritis, joint contractures, tendon friction rubs (TFRs), RP, digital ulcers (DU), puffy hands, skin sclerosis, acro-osteolysis, and calcinosis. These manifestations, which often co-exist, can contribute to difficulty with occupational activities and activities of daily living (ADL), which can result in impaired quality of life. Read More

J Am Acad Dermatol 2017 Jun 20;76(6):1115-1123. Epub 2016 Dec 20.

Department of Internal Medicine, Rouen University Hospital, Rouen, France; Institut National de la Santé et de la Recherche Médicale U 905, University of Rouen Institut Fédératif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France.

Background: Nail involvement has rarely been recognized in systemic sclerosis (SSc). Indeed, only a few small series have assessed nail changes in SSc, most of which are case reports.

Objective: The aims of the current case-control study were to: (1) determine the prevalence of fingernail changes in SSc; and (2) evaluate the correlation between fingernail changes and other features of SSc. Read More

Genet Mol Res 2016 Dec 19;15(4). Epub 2016 Dec 19.

Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde, Universidade Luterana do Brasil, Canoas, RS, Brasil

The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and degradation. Read More

Joint Bone Spine 2017 May 7;84(3):341-344. Epub 2016 Dec 7.

Pôle locomoteur, service de rhumatologie, centre Viggo Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris 7 Denis Diderot, Paris Cité Sorbonne, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:

Intravenous sodium thiosulfate (ivSTS) is a promising new therapeutic option for calciphylaxis related to end-stage renal disease. However, its effect on tumoral calcinosis (TC) complicating autoimmune connective-tissue diseases has been scarcely described. We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. Read More

Diagn Pathol 2016 Nov 21;11(1):134. Epub 2016 Nov 21.

Department of Pathology, University of Medicine and Pharmacy Craiova, Petru Rares 2, Craiova, 200349, Romania.

Background: Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and immunohistochemical data.

Case Presentation: Here we report the case of a 45-year-old female with a CEOT diagnosed and treated at the Oral & Maxillofacial Surgery Department, County Clinical Emergency Hospital of Craiova, Romania. Read More

Intern Med 2016;55(22):3315-3320. Epub 2016 Nov 15.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.

Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. Read More

Rom J Morphol Embryol 2016 ;57(2 Suppl):865-869

Department of Plastic and Reconstructive Surgery, "Prof. Dr. Agrippa Ionescu" Emergency Clinical Hospital, Bucharest, Romania;

Calcinosis consists of abnormal calcium deposition in soft tissues, which appears often in patients with limited systemic sclerosis, being one of the criteria of CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) syndrome. With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. Read More

An Bras Dermatol 2016 Sep-Oct;91(5):655-657

Sakarya University Training and Research Hospital - Sakarya, Turkey.

Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome. Read More

J Am Soc Nephrol 2016 Nov 14;27(11):3421-3429. Epub 2016 Apr 14.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Accurate identification of risk factors for calcific uremic arteriolopathy (CUA) is necessary to develop preventive strategies for this morbid disease. We investigated whether baseline factors recorded at hemodialysis initiation would identify patients at risk for future CUA in a matched case-control study using data from a large dialysis organization. Hemodialysis patients with newly diagnosed CUA (n=1030) between January 1, 2010, and December 31, 2014, were matched by age, sex, and race in a 1:2 ratio to hemodialysis patients without CUA (n=2060). Read More

Br J Dermatol 2016 Nov 20;175(5):1049-1051. Epub 2016 Jun 20.

Unit of Rheumatology, Fundación Valle del Lili, Cali, Colombia.

We present two cases of patients with systemic autoimmune diseases (one with dermatomyositis and one with CREST syndrome) who presented with a worsening of calcinosis cutis after treatment of osteoporosis with teriparatide. To our knowledge, this association is not described in the literature and might be considered in the spectrum of adverse reactions to teriparatide. Read More

J Cytol 2016 Jul-Sep;33(3):166-168

Department of Pathology, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India.

Calcinosis cutis is an uncommon condition characterized by the deposition of calcium salts in the subcutaneous tissues of the body. Calcifications can also occur in a variety of other clinical settings and can be subjected to fine-needle aspiration (FNA). Since cutaneous calcific deposits may clinically mimic a tumor, it is feasible to diagnose them by FNA cytology (FNAC). Read More

J Bone Miner Res 2016 Oct 20;31(10):1845-1854. Epub 2016 Sep 20.

Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Familial tumoral calcinosis (FTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is a rare disorder caused by mutations in the genes encoding fibroblast growth factor-23 (FGF23), N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO. The result is functional deficiency of, or resistance to, intact FGF23 (iFGF23), causing hyperphosphatemia, increased renal tubular reabsorption of phosphorus (TRP), elevated or inappropriately normal 1,25-dihydroxyvitamin D3 (1,25D), ectopic calcifications, and/or diaphyseal hyperostosis. Eight subjects with FTC/HHS were studied and treated. Read More

Am J Dermatopathol 2016 Nov;38(11):838-841

Departments of *Dermatology, †Biochemistry and Molecular Biology, ‡Surgery, and §Pathology and Dermatology, Indiana University School of Medicine, Indianapolis, IN.

In this report, the authors present a case of diffuse dermal angiomatosis (DDA) with an underlying mass lesion of the breast, which proved to be a large calcified, thrombosed artery with adjacent fat necrosis. Histologically, DDA consists of hyperplastic vessels, which diffusely infiltrate the papillary and reticular dermis forming small vascular lumina. The condition is associated with various underlying conditions, many of which result in local tissue ischemia. Read More

Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):177-180. Epub 2016 Aug 3.

Division of Rheumatology, University Hospital Zurich, Switzerland.

Objectives: Calcinosis cutis is a frequent, difficult to treat manifestation of systemic sclerosis (SSc) associated with high morbidity. The aim of this prospective, controlled, monocentric study was to assess safety and efficacy of extracorporeal shock wave therapy (ESWT) for calcinosis cutis of the finger in SSc patients.

Methods: A 12-week proof of concept study in which 4 SSc patients with calcinosis cutis were treated at one painful finger with high-energy, focused ESWT, in 3 sessions with one-week interval between each session. Read More

Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):37-42. Epub 2016 Feb 16.

Clinical Immunology Unit, Dept.
 of Medicine, Hosp. de Santo António (HSA), Centro Hospitalar do Porto (CHP); and Multidisciplinary Unit for Biomedical Investigation (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Univ. do Porto, Portugal.

Objectives: To determine the concentrations of circulating endostatin and angiostatin in patients with systemic sclerosis (SSc) and to assess its relationship to disease subsets, evolution phase, organ involvement and nailfold capillaroscopic changes.

Methods: Endostatin and angiostatin serum levels were measured by ELISA in a cohort of 57 patients with SSc, and correlated with disease subsets, evolution phase, organ involvement and nailfold capillaroscopic changes.

Results: Endostatin and angiostatin serum levels were significantly higher in patients with SSc than in healthy controls. Read More

Clin Rheumatol 2017 Jan 7;36(1):111-117. Epub 2016 Oct 7.

Direction of Education and Research, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico.

Calcinosis is a frequent complication of systemic sclerosis (SSc) that is usually located in extremities but may occur across the board. The aim of our study was to identify and quantify the distribution of calcinosis in a cohort of Mexican patients with SSc and its association with clinical features and autoantibodies. A cohort of patients with SSc (2013 ACR/EULAR criteria), classified in diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) (Le Roy criteria), was studied. Read More

Case Rep Med 2016 14;2016:7645938. Epub 2016 Sep 14.

Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, ON, Canada.

A 19-month-old boy was referred for progressive weight gain. His past medical history included congenital hypothyroidism and developmental delay. Physical examination revealed characteristics of Albright Hereditary Osteodystrophy, macrocephaly, and calcinosis cutis. Read More

Immunol Res 2016 Dec;64(5-6):1142-1149

Nephrology Unit, Department of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00161, Rome, Italy.

An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Read More

J Clin Rheumatol 2016 Oct;22(7):381

From the *Boonshoft School of Medicine, Wright State University, Dayton and †Department of Medical Education, Kettering, OH.

Dermatology 2016 14;232(5):523-533. Epub 2016 Sep 14.

Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists. They share the same clinical patterns: necrotizing livedo, skin infarctions at typical locations and acral gangrene in calciphylaxis. Read More

Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.

Dermatology, Katihar Medical college , Katihar.

Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Read More

Pediatr Dermatol 2016 Sep;33(5):555-6

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Indian J Surg 2016 Aug 19;78(4):329-30. Epub 2016 Mar 19.

Bharati Vidyapeeth Deemed University Medical College and Hospital, Sangli, India.

Idiopathic scrotal calcinosis (ISC) is a rare benign condition which presents with multiple, asymptomatic, and painless nodules on the scrotal skin wall. The lesions have been attributed as sebaceous cysts, calcified steatocystoma, fibroma, atheroma, and xanthoma. Shapiro et al. Read More

Curr Opin Rheumatol 2016 Nov;28(6):636-44

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Purpose Of Review: In dermatomyositis, disease-specific autoantibodies now cover more than 70% of patients. These autoantibodies closely correlate with distinct clinical manifestations. In the past few years, extensive evidence has been accumulated on clinical significance of dermatomyositis-specific autoantibodies including autoantibodies against melanoma differentiation antigen 5 (MDA5), transcriptional intermediary factor 1 (TIF1), nuclear matrix protein 2 (NXP2), and small ubiquitin-like modifier activating enzyme (SAE). Read More

Stem Cell Res Ther 2016 Aug 17;7(1):117. Epub 2016 Aug 17.

Department of Plastic and Reconstructive Surgery, Institute for Medical Science, Keimyung University School of Medicine, Daegu, Republic of Korea.

Background: Adipose-derived stem cells (ASCs) are important to homeostasis and the regeneration of subcutaneous fat. Hence, we examined the proliferation and differentiation capacity of irradiated ASCs over time.

Methods: Two female pigs received a single 18 Gy dose of ionizing radiation to an 18 × 8 cm area on the dorsal body skin via a 6 MeV electron beam. Read More

QJM 2016 Nov 9;109(11):753. Epub 2016 Aug 9.

Department of Dermatology, University School of Medicine Essen, Hufelandstr. 55, 45122 Essen, Germany.

Ophthal Plast Reconstr Surg 2016 Jul 29. Epub 2016 Jul 29.

*Department of Ophthalmology, King Saud University College of Medicine, Riyadh, Saudi Arabia; †Department of Ophthalmic Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; ‡Katzen Eye Group, Mercy Medical Center, Baltimore, Maryland, U.S.A.; and §King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: Subepidermal calcified nodule of the eyelid is considered as one of the types of calcinosis cutis. It generally occurs in children, and is not known to be associated with systemic disease. The authors report histopathological and clinical findings in 14 cases of subepidermal calcified nodule of the eyelid, including 3 older patients with unique microscopic features. Read More

Intern Med 2016 15;55(14):1899-905. Epub 2016 Jul 15.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.

We present the case of a non-dialyzed patient with chronic kidney disease and biopsy-proven calciphylaxis who presented with painful cutaneous ulcers on both legs. The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy. Notably, the patient's serum levels of C-reactive protein and calciprotein particles decreased and her serum albumin and fetuin-A levels increased in parallel with the alleviation of her calciphylaxis. Read More

Lupus 2016 Jun 27. Epub 2016 Jun 27.

Department of Biological Sciences, Florida International University, Miami, FL, USA; International Forensic Research Institute, Florida International University, Miami, FL, USA

Objective: The objective of this paper is to develop novel classification criteria to distinguish between unclear systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) cases.

Methods: A total of 205 variables from 111 SLE and 55 MCTD patients were evaluated to uncover unique molecular and clinical markers for each disease. Binomial logistic regressions (BLRs) were performed on currently used SLE and MCTD classification criteria sets to obtain six reduced models with power to discriminate between unclear SLE and MCTD patients that were confirmed by receiving operating characteristic (ROC) curve. Read More