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    Lacrimal punctal and peripunctal involvement in calcinosis cutis.
    Indian J Ophthalmol 2018 May;66(5):720-722
    Govindram Seksaria Institute of Dacryology, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
    Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. Read More

    Does nailfold capillaroscopy help predict future outcomes in systemic sclerosis? A systematic literature review.
    Semin Arthritis Rheum 2018 Feb 14. Epub 2018 Feb 14.
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK; Royal National Hospital for Rheumatic Diseases (at Royal United Hospitals), Upper Borough Walls, Bath, Bath BA1 1RL, UK. Electronic address:
    Background: Nailfold capillaroscopy (NC) is an important diagnostic tool in systemic sclerosis (SSc). Confirmation of NC as a prognostic factor could facilitate earlier intervention and slow disease progression in SSc. We undertook a systematic literature review to evaluate the prognostic value of NC in predicting SSc disease progression. Read More

    Calcinosis Cutis and Negative Pressure Wound Therapy as Adjuncts to Surgical Management: Case Report and Review of the Literature.
    Wounds 2018 Mar;30(3):E32-E35
    Flushing Hospital Medical Center, Queens, NY.
    Calcinosis cutis (CC), or calcium deposition in soft tissue, can cause significant morbidity associated with arthralgias and ulceration. This condition has an elusive pathophysiology and is often associated with autoimmune disorders, significantly impacting the disease burden. The clinical presentation of CC varies, and there is no gold standard treatment modality. Read More

    Calcinosis of the mandible in dermatomyositis.
    Arthritis Rheumatol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building, Center Tower, Suite 4100 Baltimore, MD 21224, USA.
    A 52-year-old woman presented to the Rheumatology clinic complaining of new tender nodules along the inferior border of her jaw. She has an 8-year history of amyopathic dermatomyositis with anti-MDA5 antibodies complicated by interstitial lung disease. Her current treatments include tacrolimus, prednisone and hydroxychloroquine. Read More

    Ultrasound characterization of cutaneous ulcers in systemic sclerosis.
    Clin Rheumatol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
    Skin ulcers in scleroderma (SSc) patients are considered a major challenge, both in clinical assessment and treatment decisions. The objective of our study is to assess ultrasonographic (US) morphology of skin ulcers in SSc patients and evaluate if US will be of value in enhancing our clinical information and influence our management plans. We examined a convenience sample of 21 skin ulcers reported in 10 SSc patients by US. Read More

    Multiple Asymptomatic Juxta-Articular Nodules Mimicking Tuberous-Xanthoma-A Unusual Presentation of Tophaceous Gout.
    J Cutan Aesthet Surg 2017 Oct-Dec;10(4):223-225
    Department of Dermatology, STD and Leprosy, Indira Gandhi E.S.I.C Hospital, Jhilmil, New Delhi.
    Asymptomatic, juxta-articular nodules are an uncommon morphology, which is usually diagnosed as xanthomas, calcinosis cutis or rheumatoid nodules. This study was represented as a case of gout, which is a disorder of purine metabolism resulting in elevation of serum uric acid and deposition of monosodium urate crystals within and around joints and manifests clinically as inflammatory arthritis. Urate crystal deposits have also been found in tendons, ligaments, viscera, and the skin, with the term "tophi" being used for the non-articular deposits. Read More

    Spontaneous and Experimentally Induced Pathologies in the Naked Mole Rat (Heterocephalus glaber).
    Biochemistry (Mosc) 2017 Dec;82(12):1504-1512
    Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia.
    The naked mole rat (Heterocephalus glaber, Rüppell, 1842) is a unique eusocial rodent with unusually long lifespan. Therefore, the study of spontaneous and experimentally induced pathologies in these animals is one of the most important tasks of gerontology. Various infections, noninfectious pathologies (including age-dependent changes), and tumors have been described in the naked mole rat. Read More

    Idiopathic Scrotal Calcinosis - A Case Report.
    Open Access Maced J Med Sci 2018 Jan 10;6(1):108-109. Epub 2018 Jan 10.
    University of Rome, Institute of Deramtology, Rome, Italy.
    Idiopathic scrotal calcinosis is a rare disorder presenting with firm and painless nodules on the scrotal skin. The most common site is the frontal aspect of the scrotum whereas the dorsal aspect with the transition to the perineum is rarely involved. Surgery is the gold standard of treatment. Read More

    Idiopathic scrotal calcinosis - A case report.
    Int J Surg Case Rep 2018 15;44:51-53. Epub 2018 Feb 15.
    Dept. of Plasticsurgery, Herlev Hospital, Copenhagen, Denmark. Electronic address:
    Introduction: Idiopathic scrotal calcinosis is a rare benign condition which presents with asymptomatic multiple nodules on the scrotal skin.

    Presentation Of Case: Our patient, a 64-year-old Indian male with Fitzpatrick skin type 4, presented with multiple nodules, which were completely surgically excised with no complications. Histological examination reveals extensive intradermal deposition of calcium surrounded by histiocytes and without cystic structure. Read More

    Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Baylor College of Medicine, Department of Dermatology, Houston, Texas.
    Eruptaneous metastasis is an uncommon presentation of colorectal adenocarcinoma that can occur years after diagnosis of the primary cancer or manifest as the first sign of malignancy. It is essential to diagnose these metastases immediately, as this late-stage development carries a poor prognosis. The scalp is one of the less common sites for skin metastases and nodules may be mistaken for benign entities. Read More

    Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database.
    Medicine (Baltimore) 2017 Dec;96(51):e8980
    Division of Rheumatology, University of California San Francisco, CA.
    Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled to date (the Genome Research in African American Scleroderma Patients (GRASP) cohort).African American SSc patients were enrolled retrospectively and prospectively over a 30-year period (1987-2016), from 18 academic centers throughout the United States. Read More

    [Dystrophic Calcinosis Cutis: a rare fearsome issue of Chronic Kidney Disease].
    G Ital Nefrol 2018 Feb;35(1)
    SOC Nefrologia e Dialisi Firenze II.
    Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma. Read More

    Cavernous hemangiomas of the temporalis muscle with prominent formation of phleboliths: Case report and review of the literature.
    Medicine (Baltimore) 2017 Dec;96(48):e8948
    Department of neurosurgery.
    Rationale: Hemangiomas are benign tumors characterized by an abnormal proliferation of blood vessels, most often occur in the skin and subcutaneous tissue, intramuscular hemangioma, a distinctive type of hemangioma within the skeletal muscle, account for <1% of all hemangiomas, temporalis muscle is a very uncommon site, cavernous hemangioma of the temporalis muscle with prominent formation of phleboliths is rare reported.

    Patient Concerns: A 62-year-old man presented with a slowly increased mass in his right temporal fossa.

    Diagnoses: Computed tomography (CT) scan showed the lesion across the zygomatic arch, with many calcified nodules differ in sizes and no erosion to the bone, magnetic resonance imaging (MRI) showed an oval lesion with hypointense and isointense on T2-weighted imaging within the temporal muscle, and preoperation diagnosis was hemangioma. Read More

    Calcinosis Cutis: WOC Nurse Management.
    J Wound Ostomy Continence Nurs 2018 Jan/Feb;45(1):83-86
    Debra Netsch, DNP, APRN, FNP-BC, CWOCN, CFCN, WEB WOC Education Programs, Minneapolis, Minnesota; and Ridgeview Medical Center, Waconia, Minnesota.
    Background: Calcinosis cutis is characterized by deposition of calcium in the dermis and the subcutaneous tissue. This condition may be initially identified by the WOC nurse, and its management requires a team approach. Calcinosis cutis is a debilitating and painful condition; it is difficult to manage, and widely agreed-upon standards for treatment have not been established. Read More

    Calcifying Acne: An Unusual Extraoral Radiographic Finding.
    Case Rep Dent 2017 2;2017:3514936. Epub 2017 Nov 2.
    Bristol Dental School, Lower Maudlin Street, Bristol, BS1 2LY, UK.
    Calcinosis cutis is a condition of accumulation of calcium salts within the dermis leading to the formation of a calcified mass. This complication has been reported in acne vulgaris and other systemic metabolic disorders. This paper presents a rare case of calcinosis cutis in a 14-year-old male which was found at a routine orthodontic assessment. Read More

    Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.
    BMC Genet 2017 Dec 8;18(1):105. Epub 2017 Dec 8.
    Department of Internal Medicine-Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Background: Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences. Read More

    Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature.
    Autoimmun Rev 2018 Feb 2;17(2):155-164. Epub 2017 Dec 2.
    Chair and Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy. Electronic address:
    Background: Skin ulcers (SU) are one of the most frequent manifestations of systemic sclerosis (SSc). SSc-SU are very painful, often persistent and recurrent; they may lead to marked impairment of patient's activities and quality of life. Despite their severe impact on the whole SSc patient's management, the proposed definition, classification criteria, and therapeutic strategies of SSc-SU are still controversial. Read More

    [A man with strange genital warts].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1715
    Catharina Ziekenhuis, afd. Dermatologie, Eindhoven.
    A 36-year-old man came to the outpatient dermatology department with asymptomatic, skin-coloured to white/yellow, firm papules on his prepuce. Over the last 10 years he had received different treatments for condylomata accuminata, with no effect. After shave excision, the diagnosis of idiopathic calcinosis cutis was made. Read More

    Calciphylaxis after parathyroidectomy.
    Hemodial Int 2017 10;21 Suppl 2:S62-S66
    Methodist Dallas Medical Center and Dallas Nephrology Associates, Dallas, Texas, USA.
    A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. Read More

    Points to consider for skin ulcers in systemic sclerosis.
    Rheumatology (Oxford) 2017 Sep;56(suppl_5):v67-v71
    Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy.
    This article discusses points to consider when undertaking a clinical trial to test therapy for skin ulcers in SSc. A validated definition of skin ulcers should be used if available. Defining a uniform SSc patient population, including consideration of disease duration, history of digital ulcers and capillaroscopic patterns, is important. Read More

    Bilateral leg ulcers secondary to dystrophic calcinosis in a patient with rheumatoid arthritis.
    J Med Invest 2017 ;64(3.4):308-310
    Department of Dermatology, Tokushima University Graduate School of Medical Science.
    Calcinosis cutis can be classified into four subtypes: dystrophic, metastatic, idiopathic, and iatrogenic. Of these subtypes, dystrophic calcinosis (DC) is the most common, and is most frequently associated with connective tissue disease, particularly dermatomyositis and systemic sclerosis, and less commonly with systemic lupus erythematosus. However, DC associated with rheumatoid arthritis (RA) is extremely rare. Read More

    J Zoo Wildl Med 2017 Sep;48(3):813-817
    Three juvenile, genetically related African lions (Panthera leo) were evaluated for discrete dome-shaped subcutaneous masses present over the proximal lateral metatarsal-tarsal area. The lesions measured 3-8 cm in diameter, were fluctuant to firm, nonulcerated, and attached to underlying structures. On radiographic evaluation, the lesions were characterized by well-circumscribed punctate mineralizations in the soft tissue surrounded by soft tissue swelling without evidence of adjacent bony involvement. Read More

    Juvenile Dermatomyositis: Key Roles of Muscle Magnetic Resonance Imaging and Early Aggressive Treatment.
    Actas Dermosifiliogr 2017 Sep 11. Epub 2017 Sep 11.
    Servicio de Dermatología, Hospital Universitario Son Espases, Palma de Mallorca, España.
    Juvenile dermatomyositis is a rare systemic connective tissue disease with onset during childhood. It presents clinically with proximal muscle weakness and characteristic skin involvement. Diagnosis is based on the Bohan and Peter criteria, though many authors are now substituting biopsy with muscle magnetic resonance imaging (MRI) for both diagnosis and follow-up. Read More

    Endothelin-1, α-Klotho, 25(OH) Vit D levels and severity of disease in scleroderma patients.
    Rheumatol Int 2017 Oct 22;37(10):1651-1657. Epub 2017 Aug 22.
    Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Considering the role of endothelin-1 (ET-1) in tissue remodeling and fibrosis during the development of scleroderma as well as the effect of α-Klotho in pathogenesis of calcinosis and/or endothelial cell injury and its correlation with severity of disease, this study aimed to evaluate serum ET-1, α-Klotho and 25(OH) vitamin D levels in patients with limited and diffuse scleroderma compared to healthy subjects. In this cross-sectional study, 60 scleroderma patients according to the ACR/EULAR 2013 criteria and 60 age- and sex-matched healthy controls were included. In patients, clinical examination was performed and Medsger severity scale was assessed. Read More

    Life-threatening subdural hematoma after aortic valve replacement in a patient with Heyde syndrome: a case report.
    J Cardiothorac Surg 2017 Aug 8;12(1):65. Epub 2017 Aug 8.
    Second Department of Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
    Background: Heyde syndrome is known as a triad of calcific aortic stenosis, anemia due to gastrointestinal bleeding from angiodysplasia, and acquired type 2A von Willebrand disease. This acquired hemorrhagic disorder is characterized by the loss of the large von Willebrand factor multimers due to the shear stress across the diseased aortic valve. The most frequently observed type of bleeding in these patients is mucosal or skin bleeding, such as epistaxis, followed by gastrointestinal bleeding. Read More

    Idiopathic Calcinosis Cutis Universalis Treated Successfully with Oral Diltiazem-A Case Report.
    Pediatr Dermatol 2017 Sep 2;34(5):e241-e244. Epub 2017 Aug 2.
    Department of Dermatology, SMS Medical College & Hospital, Jaipur, Rajasthan, India.
    Idiopathic calcinosis cutis is very rare and difficult to treat. Various medical modalities of treatment described with inconsistent results include chelating agents, colchicine, and probenecid. Calcium channel blockers are known to work by inhibiting intracellular entry of calcium. Read More

    Quartz Crystal Microbalance Assay of Clinical Calcinosis Samples and Their Synthetic Models Differentiates the Efficacy of Chelation-Based Treatments.
    ACS Appl Mater Interfaces 2017 Aug 15;9(33):27544-27552. Epub 2017 Aug 15.
    Manchester Institute of Biotechnology, University of Manchester , 131 Princess Street, Manchester, M1 7DN, U.K.
    This paper sets out in vitro protocols for studying the relative effectiveness of chelators used in the dissolution-based treatment of hard calcinosis. Pulverized hard calcinosis samples from human donors or synthetic hydroxyapatite nanoparticles were deposited by electrophoretic deposition on the surface of a quartz crystal microbalance sensor. Over 150 deposits of <20 μg were dissolved over the course of 1 h by aliquots of buffered, aqueous solutions of two calcium chelators, EDTA and citrate, with the surface-limited dissolution kinetics monitored with <1 s time resolution. Read More

    Phenotypic characteristics and outcome of juvenile dermatomyositis in Arab children.
    Rheumatol Int 2017 Sep 6;37(9):1513-1517. Epub 2017 Jul 6.
    Consultant and Section Head, Rheumatology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Po Box 3354, Riyadh, 11211, Saudi Arabia.
    This study describes the disease characteristics and outcome of Arab children with juvenile dermatomyositis (JDM) and compares the findings with other ethnicities. We retrospectively reviewed the hospital registries of the participating hospitals for children with JDM seen between 1990 and 2016 in three Arab countries. All patients fulfilled Bohan and Peter criteria for JDM, diagnosed before 14 years of age and were of Arab ethnicity. Read More

    Management of a Complex Peristomal Calciphylaxis: A Case Study.
    J Wound Ostomy Continence Nurs 2017 Jul/Aug;44(4):380-383
    Mary Famorca, MAN, RN, WCC, COCN, Mayo Clinic Arizona, Phoenix, Arizona. Debra Beauchaine, MN, RN, AGPCNP, CWOCN-AP, Mayo Clinic Arizona, Phoenix, Arizona. Nancy Angulo, BS, RN, CWOCN, Cancer Treatment Center of America, Goodyear, Arizona.
    Background: Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare and serious syndrome of small blood vessels with a high mortality rate. Calciphylaxis lesions require intensive wound management with medical interventions for the patient to survive the sequelae of sepsis and present unique challenges when found in the peristomal skin.

    Case: A 33-year-old man presented with multiple malodorous stage 4 pressure injuries of his sacrococcygeal and gluteal area. Read More

    Metastatic calcinosis cutis in end-stage renal disease.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):368-369
    Department of Internal Medicine, Baylor Scott and White Hospital and Texas A&M Health Science Center College of Medicine, Temple, Texas.
    Alterations in calcium and phosphorus levels and joint pain are a common occurrence in end-stage renal disease patients. However, metastatic calcinosis cutis is a rare diagnosis that often combines these two findings, with extensive soft tissue calcification surrounding a large joint being the hallmark of this disease. The exact mechanism behind this clinical entity is unknown. Read More

    Lack of response to intravenous sodium thiosulfate in three cases of extensive connective tissue disease-associated calcinosis cutis.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Brigham and Women's Hospital, Department of Dermatology, Harvard Medical School, Boston, MA, U.S.A.
    Dystrophic calcinosis cutis is a debilitating condition of calcium salt deposition in the skin often occurring in association with connective tissue disease (CTD). Available treatments for calcinosis cutis are unsatisfactory, but given the recent use of topical and intralesional sodium thiosulfate (STS) to treat calcifying disorders, we sought to describe the use of intravenous (IV) STS for CTD-associated dystrophic calcinosis cutis. We report three patients with long-standing and extensive CTD-associated calcinosis cutis treated with IV STS after having failed multiple prior therapies. Read More

    High-Velocity Paint Gun Injuries.
    Am J Dermatopathol 2017 Aug;39(8):606-613
    *Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX; †Department of Pathology, University of Colorado, Denver, CO; ‡Western Pathology, Inc., San Luis Obispo, CA; and §Loyola Stritch School of Medicine, Chicago, IL.
    Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. Read More

    Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy.
    Arthritis Rheumatol 2017 10 22;69(10):2081-2091. Epub 2017 Aug 22.
    INSERM UMR 1163, Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, and Hôpital Necker Enfants Malades, AP-HP Paris, Paris, France, and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Objective: To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet, including camptodactyly, subluxation, and tendon rupture, reminiscent of Jaccoud's arthropathy.

    Methods: We identified 2 families segregating an autosomal-dominant phenotype encompassing musculoskeletal disease and variable additional features, including psoriasis, dental abnormalities, cardiac valve involvement, glaucoma, and basal ganglia calcification. We measured the expression of interferon (IFN)-stimulated genes in the peripheral blood and skin, and undertook targeted Sanger sequencing of the IFIH1 gene encoding the cytosolic double-stranded RNA (dsRNA) sensor melanoma differentiation-associated protein 5 (MDA-5). Read More

    Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.
    Sci Transl Med 2017 Jun;9(393)
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
    Biallelic mutations in cause pseudoxanthoma elasticum (PXE), a disease characterized by calcification in the skin, eyes, and blood vessels. The function of ATP-binding cassette C6 (ABCC6) and the pathogenesis of PXE remain unclear. We used mouse models and patient fibroblasts to demonstrate genetic interaction and shared biochemical and cellular mechanisms underlying ectopic calcification in PXE and related disorders caused by defined perturbations in extracellular adenosine 5'-triphosphate catabolism. Read More

    Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules.
    PLoS One 2017 11;12(5):e0177375. Epub 2017 May 11.
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Gamma-glutamyl carboxylase (GGCX) gene mutation causes GGCX syndrome (OMIM: 137167), which is characterized by pseudoxanthoma elasticum (PXE)-like symptoms and coagulation impairment. Here, we present a 55-year-old male with a novel homozygous deletion mutation, c.2,221delT, p. Read More

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