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    1 OF 51

    Relationship between calcium channel blockers and skin fibrosis in patients with systemic sclerosis.
    Clin Exp Rheumatol 2017 Jan 31. Epub 2017 Jan 31.
    St. Joseph's Healthcare Hamilton, ON; and Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
    Objectives: Recent experimental evidence suggests that calcium channel blockers (CCBs) may have anti-fibrotic effects on liver and pulmonary fibrosis. We aimed to investigate whether use of CCBs was associated with the skin fibrosis in patients with systemic sclerosis (SSc).

    Methods: Based on the 5-year follow-up data from the Canadian Scleroderma Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin fibrosis measured by the modified Rodnan skin score (mRSS). Read More

    Unilateral Idiopathic Calcinosis Cutis: A Case Report.
    Case Rep Dermatol 2017 Jan-Apr;9(1):20-24. Epub 2017 Jan 27.
    Department of Dermatology, King Saud Medical City, Riyadh, Saudi Arabia.
    Calcinosis cutis is a rare disorder characterized by the deposition of calcium in the skin and subcutaneous tissue. Unilateral idiopathic calcinosis cutis has only rarely been reported in the literature. Here, we report the case of a 7-year-old healthy girl who presented with multiple asymptomatic hard nodules on the right side of her body. Read More

    Juvenile dermatomyositis in a 4-year-old Kenyan girl.
    Clin Case Rep 2017 Feb 17;5(2):134-138. Epub 2017 Jan 17.
    Department of Internal Medicine Kilimanjaro Christian Medical Centre Moshi United Republic of Tanzania.
    To our knowledge, this is the first case report of juvenile dermatomyositis (JDM) in Tanzania. It demonstrates that the characteristic cutaneous findings of JDM may easily be overlooked, especially on dark skin, and the difficulty of clinical management in resource-constrained settings. Read More

    The family impact of caring for a child with juvenile dermatomyositis.
    Chronic Illn 2017 Jan 1:1742395317690034. Epub 2017 Jan 1.
    Pacific Graduate School of Psychology, Palo Alto University, Palo Alto, CA, USA.
    Background Juvenile dermatomyositis (JDM), a rare autoimmune disease, accounts for more than 80% of idiopathic inflammatory myopathy childhood cases, making it the most common idiopathic inflammatory myopathy among children. The average age of onset is approximately 7 years and commonly leads a chronic course. Symptoms of JDM include cutaneous features (Gottron's rash, heliotrope rash, or nail fold capillary changes), musculoskeletal features, calcinosis and lipodystrophy (a symmetrical deficit of subcutaneous fatty tissue), and acanthosis (thickening of the skin). Read More

    The cutaneous and systemic findings associated with nuclear matrix protein-2 antibodies in adult dermatomyositis patients.
    Arthritis Care Res (Hoboken) 2017 Jan 27. Epub 2017 Jan 27.
    Department of Dermatology, Stanford University School of Medicine, Stanford, CA.
    Objective: To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with anti-NXP-2 antibodies.

    Methods: We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. Electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Read More

    Calcinosis Cutis Circumscripta Of Knee-A Rare Presentation.
    J Orthop Case Rep 2016 Jul-Aug;6(3):78-79
    Department of Orthopaedics, ACPM Medical College, Dhule-424001, Maharashtra, India.
    Introduction: Calcinosis circumscripta is a form of ectopic mineralization characterized by single or multiple cutaneous nodules containing calcium salts. Calcinosis cutis circumscripta is a very rare form of idiopathic calcinosis cutis arising in the second half oflife. It typically involves the extremities and is associated with prior trauma and scleroderma. Read More

    Dermatomyositis Patients with Anti-Nuclear Matrix Protein-2 Autoantibodies Have More Edema, More Severe Muscle Disease, and Increased Malignancy Risk.
    Arthritis Care Res (Hoboken) 2017 Jan 13. Epub 2017 Jan 13.
    Johns Hopkins University School of Medicine, Baltimore, MD.
    Objectives: Dermatomyositis (DM) patients typically present with proximal weakness and autoantibodies that are associated with distinct clinical phenotypes. We observed that DM patients with autoantibodies recognizing the nuclear matrix protein NXP-2 often presented with especially severe weakness. The aim of this study was to characterize clinical features associated with anti-NXP-2 autoantibodies. Read More

    Juvenile dermatomyositis: a tertiary center experience.
    Clin Rheumatol 2017 Feb 5;36(2):361-366. Epub 2017 Jan 5.
    Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
    Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of patients with JDM at a referral pediatric rheumatology center in Turkey. Read More

    [Advanced Systemic Sclerosis: Endovascular Reconstruction of the Aortic Bifurcation for Limb Salvage].
    Dtsch Med Wochenschr 2017 Jan 5;142(1):43-46. Epub 2017 Jan 5.
    Zentrum für Radiologie, Bergisches Gefäßzentrum, HELIOS Universitätsklinikum Wuppertal, Universität Witten/Herdecke.
    History and admission findings A 69-year-old patient was initially hospitalized because of a 1.5 cm ulceration at the back of the right foot which had existed for the last year and become increasingly swollen and painful. Medical history revealed PmScl-positive systemic sclerosis presenting with a massive calcinosis cutis, advanced pulmonary fibrosis and peripheral artery disease. Read More

    Rothmund-Thomson syndrome and osteoma cutis in a patient previously diagnosed as COPS syndrome.
    Eur J Pediatr 2017 Feb 30;176(2):279-283. Epub 2016 Dec 30.
    Department of Clinical genetics, Leiden University Medical Centre, Postzone K5-R, PO box 9600, 2300 RC, Leiden, The Netherlands.
    We present a patient with poikiloderma, severe osteoporosis and a mild intellectual disability. At the age of 9 years, this patient was proposed to suffer from a novel disease entity designated as calcinosis cutis, osteoma cutis, poikiloderma and skeletal abnormalities (COPS) syndrome. At the age of 35, he was diagnosed with Hodgkin's lymphoma. Read More

    Hand Impairment in Systemic Sclerosis: Various Manifestations and Currently Available Treatment.
    Curr Treatm Opt Rheumatol 2016 Sep 19;2(3):252-269. Epub 2016 Jul 19.
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; University of Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Systemic sclerosis (SSc) is an autoimmune disease initially recognized by hand involvement due to characteristic Raynaud's phenomenon (RP), puffy hands, skin thickening, and contractures resembling claw deformities. SSc contributes to hand impairment through inflammatory arthritis, joint contractures, tendon friction rubs (TFRs), RP, digital ulcers (DU), puffy hands, skin sclerosis, acro-osteolysis, and calcinosis. These manifestations, which often co-exist, can contribute to difficulty with occupational activities and activities of daily living (ADL), which can result in impaired quality of life. Read More

    Nail involvement in systemic sclerosis.
    J Am Acad Dermatol 2016 Dec 20. Epub 2016 Dec 20.
    Department of Internal Medicine, Rouen University Hospital, Rouen, France; Institut National de la Santé et de la Recherche Médicale U 905, University of Rouen Institut Fédératif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France.
    Background: Nail involvement has rarely been recognized in systemic sclerosis (SSc). Indeed, only a few small series have assessed nail changes in SSc, most of which are case reports.

    Objective: The aims of the current case-control study were to: (1) determine the prevalence of fingernail changes in SSc; and (2) evaluate the correlation between fingernail changes and other features of SSc. Read More

    Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.
    Genet Mol Res 2016 Dec 19;15(4). Epub 2016 Dec 19.
    Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde, Universidade Luterana do Brasil, Canoas, RS, Brasil
    The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and degradation. Read More

    Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases.
    Joint Bone Spine 2016 Dec 7. Epub 2016 Dec 7.
    Pôle locomoteur, service de rhumatologie, centre Viggo Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris 7 Denis Diderot, Paris Cité Sorbonne, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:
    Intravenous sodium thiosulfate (ivSTS) is a promising new therapeutic option for calciphylaxis related to end-stage renal disease. However, its effect on tumoral calcinosis (TC) complicating autoimmune connective-tissue diseases has been scarcely described. We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. Read More

    Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study.
    Diagn Pathol 2016 Nov 21;11(1):134. Epub 2016 Nov 21.
    Department of Pathology, University of Medicine and Pharmacy Craiova, Petru Rares 2, Craiova, 200349, Romania.
    Background: Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and immunohistochemical data.

    Case Presentation: Here we report the case of a 45-year-old female with a CEOT diagnosed and treated at the Oral & Maxillofacial Surgery Department, County Clinical Emergency Hospital of Craiova, Romania. Read More

    Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis.
    Intern Med 2016;55(22):3315-3320. Epub 2016 Nov 15.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
    Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. Read More

    A case of a generalized symptomatic calcinosis in systemic sclerosis.
    Rom J Morphol Embryol 2016 ;57(2 Suppl):865-869
    Department of Plastic and Reconstructive Surgery, "Prof. Dr. Agrippa Ionescu" Emergency Clinical Hospital, Bucharest, Romania;
    Calcinosis consists of abnormal calcium deposition in soft tissues, which appears often in patients with limited systemic sclerosis, being one of the criteria of CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) syndrome. With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. Read More

    Milia-like calcinosis cutis in a girl with Down syndrome.
    An Bras Dermatol 2016 Sep-Oct;91(5):655-657
    Sakarya University Training and Research Hospital - Sakarya, Turkey.
    Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome. Read More

    Worsening of calcinosis cutis with teriparatide treatment in two osteoporotic patients.
    Br J Dermatol 2016 Nov 20;175(5):1049-1051. Epub 2016 Jun 20.
    Unit of Rheumatology, Fundación Valle del Lili, Cali, Colombia.
    We present two cases of patients with systemic autoimmune diseases (one with dermatomyositis and one with CREST syndrome) who presented with a worsening of calcinosis cutis after treatment of osteoporosis with teriparatide. To our knowledge, this association is not described in the literature and might be considered in the spectrum of adverse reactions to teriparatide. Read More

    Iatrogenic calcinosis cutis: A rare cytological diagnosis.
    J Cytol 2016 Jul-Sep;33(3):166-168
    Department of Pathology, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
    Calcinosis cutis is an uncommon condition characterized by the deposition of calcium salts in the subcutaneous tissues of the body. Calcifications can also occur in a variety of other clinical settings and can be subjected to fine-needle aspiration (FNA). Since cutaneous calcific deposits may clinically mimic a tumor, it is feasible to diagnose them by FNA cytology (FNAC). Read More

    Phenotypic and Genotypic Characterization and Treatment of a Cohort With Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome.
    J Bone Miner Res 2016 Oct 20;31(10):1845-1854. Epub 2016 Sep 20.
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
    Familial tumoral calcinosis (FTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is a rare disorder caused by mutations in the genes encoding fibroblast growth factor-23 (FGF23), N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO. The result is functional deficiency of, or resistance to, intact FGF23 (iFGF23), causing hyperphosphatemia, increased renal tubular reabsorption of phosphorus (TRP), elevated or inappropriately normal 1,25-dihydroxyvitamin D3 (1,25D), ectopic calcifications, and/or diaphyseal hyperostosis. Eight subjects with FTC/HHS were studied and treated. Read More

    Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis.
    Am J Dermatopathol 2016 Nov;38(11):838-841
    Departments of *Dermatology, †Biochemistry and Molecular Biology, ‡Surgery, and §Pathology and Dermatology, Indiana University School of Medicine, Indianapolis, IN.
    In this report, the authors present a case of diffuse dermal angiomatosis (DDA) with an underlying mass lesion of the breast, which proved to be a large calcified, thrombosed artery with adjacent fat necrosis. Histologically, DDA consists of hyperplastic vessels, which diffusely infiltrate the papillary and reticular dermis forming small vascular lumina. The condition is associated with various underlying conditions, many of which result in local tissue ischemia. Read More

    Safety and efficacy of extracorporeal shock wave therapy (ESWT) in calcinosis cutis associated with systemic sclerosis.
    Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):177-180. Epub 2016 Aug 3.
    Division of Rheumatology, University Hospital Zurich, Switzerland.
    Objectives: Calcinosis cutis is a frequent, difficult to treat manifestation of systemic sclerosis (SSc) associated with high morbidity. The aim of this prospective, controlled, monocentric study was to assess safety and efficacy of extracorporeal shock wave therapy (ESWT) for calcinosis cutis of the finger in SSc patients.

    Methods: A 12-week proof of concept study in which 4 SSc patients with calcinosis cutis were treated at one painful finger with high-energy, focused ESWT, in 3 sessions with one-week interval between each session. Read More

    Different contributions of angiostatin and endostatin in angiogenesis impairment in systemic sclerosis: a cohort study.
    Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):37-42. Epub 2016 Feb 16.
    Clinical Immunology Unit, Dept.
 of Medicine, Hosp. de Santo António (HSA), Centro Hospitalar do Porto (CHP); and Multidisciplinary Unit for Biomedical Investigation (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Univ. do Porto, Portugal.
    Objectives: To determine the concentrations of circulating endostatin and angiostatin in patients with systemic sclerosis (SSc) and to assess its relationship to disease subsets, evolution phase, organ involvement and nailfold capillaroscopic changes.

    Methods: Endostatin and angiostatin serum levels were measured by ELISA in a cohort of 57 patients with SSc, and correlated with disease subsets, evolution phase, organ involvement and nailfold capillaroscopic changes.

    Results: Endostatin and angiostatin serum levels were significantly higher in patients with SSc than in healthy controls. Read More

    Clinical, biochemical, and radiological characterization of the calcinosis in a cohort of Mexican patients with systemic sclerosis.
    Clin Rheumatol 2017 Jan 7;36(1):111-117. Epub 2016 Oct 7.
    Direction of Education and Research, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico.
    Calcinosis is a frequent complication of systemic sclerosis (SSc) that is usually located in extremities but may occur across the board. The aim of our study was to identify and quantify the distribution of calcinosis in a cohort of Mexican patients with SSc and its association with clinical features and autoantibodies. A cohort of patients with SSc (2013 ACR/EULAR criteria), classified in diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) (Le Roy criteria), was studied. Read More

    The Association of Pseudohypoparathyroidism Type Ia with Chiari Malformation Type I: A Coincidence or a Common Link?
    Case Rep Med 2016 14;2016:7645938. Epub 2016 Sep 14.
    Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, ON, Canada.
    A 19-month-old boy was referred for progressive weight gain. His past medical history included congenital hypothyroidism and developmental delay. Physical examination revealed characteristics of Albright Hereditary Osteodystrophy, macrocephaly, and calcinosis cutis. Read More

    ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review.
    Immunol Res 2016 Dec;64(5-6):1142-1149
    Nephrology Unit, Department of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00161, Rome, Italy.
    An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Read More

    Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology.
    Dermatology 2016 14;232(5):523-533. Epub 2016 Sep 14.
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists. They share the same clinical patterns: necrotizing livedo, skin infarctions at typical locations and acral gangrene in calciphylaxis. Read More

    Milia-like idiopathic calcinosis cutis in a child with Down syndrome.
    Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.
    Dermatology, Katihar Medical college , Katihar.
    Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Read More

    Idiopathic Scrotal Calcinosis.
    Indian J Surg 2016 Aug 19;78(4):329-30. Epub 2016 Mar 19.
    Bharati Vidyapeeth Deemed University Medical College and Hospital, Sangli, India.
    Idiopathic scrotal calcinosis (ISC) is a rare benign condition which presents with multiple, asymptomatic, and painless nodules on the scrotal skin wall. The lesions have been attributed as sebaceous cysts, calcified steatocystoma, fibroma, atheroma, and xanthoma. Shapiro et al. Read More

    Recent advances in dermatomyositis-specific autoantibodies.
    Curr Opin Rheumatol 2016 Nov;28(6):636-44
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
    Purpose Of Review: In dermatomyositis, disease-specific autoantibodies now cover more than 70% of patients. These autoantibodies closely correlate with distinct clinical manifestations. In the past few years, extensive evidence has been accumulated on clinical significance of dermatomyositis-specific autoantibodies including autoantibodies against melanoma differentiation antigen 5 (MDA5), transcriptional intermediary factor 1 (TIF1), nuclear matrix protein 2 (NXP2), and small ubiquitin-like modifier activating enzyme (SAE). Read More

    Serial changes in the proliferation and differentiation of adipose-derived stem cells after ionizing radiation.
    Stem Cell Res Ther 2016 Aug 17;7(1):117. Epub 2016 Aug 17.
    Department of Plastic and Reconstructive Surgery, Institute for Medical Science, Keimyung University School of Medicine, Daegu, Republic of Korea.
    Background: Adipose-derived stem cells (ASCs) are important to homeostasis and the regeneration of subcutaneous fat. Hence, we examined the proliferation and differentiation capacity of irradiated ASCs over time.

    Methods: Two female pigs received a single 18 Gy dose of ionizing radiation to an 18 × 8 cm area on the dorsal body skin via a 6 MeV electron beam. Read More

    Subepidermal Calcified Nodules of the Eyelid Differ in Children and Adults.
    Ophthal Plast Reconstr Surg 2016 Jul 29. Epub 2016 Jul 29.
    *Department of Ophthalmology, King Saud University College of Medicine, Riyadh, Saudi Arabia; †Department of Ophthalmic Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; ‡Katzen Eye Group, Mercy Medical Center, Baltimore, Maryland, U.S.A.; and §King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
    Purpose: Subepidermal calcified nodule of the eyelid is considered as one of the types of calcinosis cutis. It generally occurs in children, and is not known to be associated with systemic disease. The authors report histopathological and clinical findings in 14 cases of subepidermal calcified nodule of the eyelid, including 3 older patients with unique microscopic features. Read More

    Can SLE classification rules be effectively applied to diagnose unclear SLE cases?
    Lupus 2016 Jun 27. Epub 2016 Jun 27.
    Department of Biological Sciences, Florida International University, Miami, FL, USA; International Forensic Research Institute, Florida International University, Miami, FL, USA
    Objective: The objective of this paper is to develop novel classification criteria to distinguish between unclear systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) cases.

    Methods: A total of 205 variables from 111 SLE and 55 MCTD patients were evaluated to uncover unique molecular and clinical markers for each disease. Binomial logistic regressions (BLRs) were performed on currently used SLE and MCTD classification criteria sets to obtain six reduced models with power to discriminate between unclear SLE and MCTD patients that were confirmed by receiving operating characteristic (ROC) curve. Read More

    Calciphylaxis of the Breast: A Case Report and Literature Review.
    Breast J 2016 Sep 22;22(5):568-72. Epub 2016 Jun 22.
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
    Calciphylaxis, or calcific uremic arteriolopathy, is a rare but particularly morbid condition involving systemic medial calcification of arterioles causing ischemia and subsequent tissue necrosis. Although most commonly occurring over the abdomen and proximal extremities, calciphylaxis can present on nearly any skin surface with a tendency toward areas of increased adiposity. We report a case of a 53-year-old female with end-stage renal disease who presented with bilateral palpable breast masses and overlying skin changes. Read More

    Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.
    Semin Arthritis Rheum 2016 Oct 18;46(2):200-8. Epub 2016 May 18.
    Department of Internal Medicine, Hospital Valld'Hebron, Barcelona, Spain.
    Objective: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc.

    Methods: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Read More

    Tumoral Calcinosis as an Initial Complaint of Juvenile-Onset Amyopathic Dermatomyositis.
    Ann Dermatol 2016 Jun 25;28(3):375-80. Epub 2016 May 25.
    Department of Dermatology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
    Calcinosis is rarely observed in juvenile-onset amyopathic dermatomyositis in contrast to juvenile-onset dermatomyositis. A 6-year-old female presented with several 0.5 to 2 cm-sized painless grouped masses on both knees for 3 years. Read More

    Calcinosis in systemic sclerosis: subsets, distribution and complications.
    Rheumatology (Oxford) 2016 Sep 30;55(9):1610-4. Epub 2016 May 30.
    Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy.
    Objective: To retrospectively analyse the features of calcinosis in a cohort of SSc patients.

    Methods: Charts of SSc patients attending the Ulcer Unit of the Rheumatology Department, University of Florence and presenting a clinical suspicion of calcinosis were considered in the study. Data on clinical history, including recent skin changes, and clinical examination of all areas with suspected calcinosis, radiological imaging of the calcinotic area, demographics and SSc-related organ involvement and pain measured by a visual analogue scale were recorded. Read More

    Retrograde Approach Using Surgical Cutdown Technique for Limb Salvage in a Case of Critical Limb Ischemia With Severely Calcified Tibial Occlusive Disease.
    Vasc Endovascular Surg 2016 May;50(4):295-8
    Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Hyogo, Japan.
    We here report a successful angioplasty for tibial artery occlusion using direct tibial puncture and subsequent retrograde approach under surgical cutdown technique. An 82-year-old man with ulcer/gangrene in first and second digits was referred to our hospital for endovascular therapy (EVT) of lower extremity ischemia. Diagnostic angiogram revealed anterior tibial artery (ATA) occlusion with severe calcification. Read More

    Active subcutaneous calcinosis demonstrated by fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in a case of limited cutaneous systemic sclerosis.
    Indian J Nucl Med 2016 Apr-Jun;31(2):154-5
    Department of Nuclear Medicine, IRCCS Cà Granda Maggiore Policlinico Hospital Foundation, Milan, Italy.
    Systemic sclerosis (SSc) is a rheumatic autoimmune disease of unknown origin causing fibrosis of the skin and the internal organs. The limited cutaneous variant is the most common subtype of SSc, and it is predominantly characterized by skin and soft-tissues involvement. A 72-year-old woman, who had been diagnosed with the limited cutaneous form of SSc 16 years before, underwent fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) examination due to unexplained weight loss and recent onset of fatigue and joint pain. Read More

    POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification.
    Orphanet J Rare Dis 2016 Apr 12;11:35. Epub 2016 Apr 12.
    Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
    Background: Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, a systemic disease associated with plasma cell dyscrasia and upregulation of vascular endothelial growth factor (VEGF). Read More

    Pathomorphological features of calcinosis circumscripta in a dog.
    Lab Anim Res 2016 Mar 24;32(1):74-7. Epub 2016 Mar 24.
    College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.; Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Korea.
    A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple well-circumscribed nodules with a chalky appearance. Read More

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