5,497 results match your criteria Calcified tissue international[Journal]


Annual Injection of Zoledronic Acid Improves Bone Status in Children with Cerebral Palsy and Rett Syndrome.

Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.

Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.

Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0505-2DOI Listing
December 2018

Bone Marrow Transplantation for Treatment of the Col1a2 Osteogenesis Imperfecta Mouse Model.

Calcif Tissue Int 2018 Dec 8. Epub 2018 Dec 8.

Orthopaedic Research and Biotechnology Unit, Kids Research, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.

Bone marrow transplantation (BMT) of healthy donor cells has been postulated as a strategy for treating osteogenesis imperfecta (OI) and other bone fragility disorders. The effect of engraftment by tail vein injection and/or marrow ablation by 6 Gy whole body irradiation were tested in Col1a2 (OI) mice as a model of mild-moderate OI. Dual-emission X-ray absorptiometry, microCT, and 4-point bending were used to measure bone volume (BV), bone mineral density (BMD), and biomechanical strength. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0504-3DOI Listing
December 2018

Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca/Calmodulin-Dependent Protein Kinase II.

Calcif Tissue Int 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China.

Hyperglycemia induces osteoclastogenesis and bone resorption through complicated, undefined mechanisms. Ca/calmodulin-dependent protein kinase II (CaMKII) promotes osteoclastogenesis, and could be activated by hyperglycemia. Here, we investigated whether CaMKII is involved in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0499-9DOI Listing
December 2018
1 Read

Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification.

Calcif Tissue Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA.

Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities of daily living and pain. While soft tissue injury is a prerequisite of developing HO, the exact molecular pathology leading to trauma-induced HO remains unknown. Through prior investigations aimed at identifying the causative factors of HO, it has been suggested that additional predisposing factors that favor ossification within the injured soft tissues environment are required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0502-5DOI Listing
December 2018
2 Reads

Association Between the Decline in Muscle Health and the Decline in Bone Health in Older Individuals from the SarcoPhAge Cohort.

Calcif Tissue Int 2018 Dec 3. Epub 2018 Dec 3.

World Health Organization Collaborating Center for the Public Health Aspects of Musculoskeletal Health and Aging, Department of Public Health Sciences, Epidemiology and Health Economics, University of Liège, CHU of Liège, B.23, Avenue Hippocrate, 13, 4000, Liège, Belgium.

The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the relationship between bone decline and muscle decline over 1 year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0503-4
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0503-4DOI Listing
December 2018
2 Reads

Fracture Risk in Women with Dysglycaemia: Assessing Effects of Baseline and Time-Varying Risk Factors.

Calcif Tissue Int 2018 Nov 27. Epub 2018 Nov 27.

Deakin University, Geelong, VIC, 3220, Australia.

Although individuals with diabetes appear to have a higher fracture risk compared to those without diabetes, fracture risk in impaired fasting glucose (IFG) has not been thoroughly explored. This study determined associations between glycaemia status and fracture risk. Women (n = 575, aged 50 + years) enrolled in the Geelong Osteoporosis Study, were followed from baseline (1993-1997), to date of first fracture, death or December 31, 2010, whichever occurred first (median 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0498-xDOI Listing
November 2018
3 Reads

Sequential Treatment with Eldecalcitol After PTH Improves Bone Mechanical Properties of Lumbar Spine and Femur in Aged Ovariectomized Rats.

Calcif Tissue Int 2018 Nov 22. Epub 2018 Nov 22.

Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan.

Parathyroid hormone (PTH) analogs have a powerful anabolic effect on bone and are used in the treatment of patients with severe osteoporosis. However, there are limitations to how long they can be safely administered. Withdrawal of PTH results in the cancelation of its effects, necessitating subsequent treatment to maintain the bone quantity and quality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0497-yDOI Listing
November 2018
4 Reads

Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading.

Calcif Tissue Int 2018 Nov 21. Epub 2018 Nov 21.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio - Coppito 2, 67100, L'aquila, Italy.

During mechanical unloading, endothelial cells reduce osteogenesis and increase bone resorption. Here we describe the feedback response of endothelial cells to unloaded osteoblasts. Primary endothelial cells, ex vivo mouse aortic rings and chicken egg yolk membranes were incubated with conditioned medium from mouse primary osteoblasts (OB-CM) subjected to unit gravity or simulated microgravity, to assess its effect on angiogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0496-zDOI Listing
November 2018
13 Reads

Chronic Non-bacterial Osteomyelitis: A Review.

Calcif Tissue Int 2018 Nov 19. Epub 2018 Nov 19.

Department of Endocrinology, Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Chronic non-bacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disorder, with a prevalence of around one in a million patients. In the more severe form, it is referred to as chronic recurrent multifocal osteomyelitis (CRMO). We present the current knowledge on epidemiology, pathophysiology as well as diagnostic options and treatment regimens. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0495-0
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0495-0DOI Listing
November 2018
7 Reads

Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Phenotype Markers in Primary Human Chondrocytes by a Calcium/Calmodulin Kinase 2-Dependent Mechanism.

Calcif Tissue Int 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, School of Medicine, University of Auckland, Auckland, New Zealand.

Chondrocytes in osteoarthritis undergo a phenotype shift leading to increased production of cartilage-degrading enzymes. There are similarities between the phenotype of osteoarthritic chondrocytes and those of growth plate chondrocytes. Hydroxyapatite can promote chondrocyte differentiation in the growth plate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0494-1DOI Listing
November 2018
6 Reads

Bisphosphonates Use and Risk of Subtrochanteric and Diaphyseal Femur Fractures in Korea: Results from the National Claim Registry.

Calcif Tissue Int 2018 Nov 16. Epub 2018 Nov 16.

Department of Orthopaedic Surgery, School of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Although Asian with bisphosphonate has been considered to have higher risk of subtrochanteric and diaphyseal femur (ST/DF) fractures, the occurrence of those fractures has been still unclear in Asia. The purpose of this study was to investigate the incidence rate of ST/DF fractures among bisphosphonate users from nationwide database in South Korea. Using national health insurance claim database, we only included the bisphosphonate users who took bisphosphonate for the first time in 2008 and evaluated the incidence rate of ST/DF fracture from 2008 to 2013. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0493-2
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0493-2DOI Listing
November 2018
8 Reads

Trabecular Bone Score (TBS) and Bone Metabolism in Patients Affected with Type 1 Neurofibromatosis (NF1).

Calcif Tissue Int 2018 Nov 12. Epub 2018 Nov 12.

Unit of Endocrinology and Metabolic Diseases, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

In patients with neurofibromatosis type 1 (NF1), decreased bone mineral density (BMD) and low levels of 25-hydroxy vitamin D3 (25OHD) have been reported. Recently, the trabecular bone score (TBS) measurement has been proposed as index of bone microarchitecture and fracture risk. In 74 NF1 patients (48 females, 26 males, age 41 ± 12), we measured TBS and investigated clinical stage, lifestyle, vitamin D, serum bone turnover markers, vertebral and femoral BMD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0488-zDOI Listing
November 2018
1 Read

A Bibliometric Study of Authorship and Collaboration Trends Over the Past 30 Years in Four Major Musculoskeletal Science Journals.

Calcif Tissue Int 2018 Nov 11. Epub 2018 Nov 11.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

This study explored changes in bibliometric variables over the last 30 years for four major musculoskeletal science journals (BONE®), Calcified Tissue International® (CTI®), Journal of Bone and Mineral Research® (JBMR®), and Journal of Orthopaedic Research® (JOR®), with a specific focus on author gender. Bibliometric data were collected for all manuscripts in 1985 (BONE®, CTI®, JOR®), 1986 (JBMR®), 1995, 2005, and 2015; 2776 manuscripts met inclusion criteria. Manuscripts from Europe were more often published in BONE® or CTI®, while those from North America in JBMR® or JOR®. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0492-3DOI Listing
November 2018
1 Read

Effect of Long-Term Green Tea Polyphenol Supplementation on Bone Architecture, Turnover, and Mechanical Properties in Middle-Aged Ovariectomized Rats.

Calcif Tissue Int 2018 Nov 9. Epub 2018 Nov 9.

Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA.

We investigated the effects of 6-month green tea polyphenols (GTP) supplementation on bone architecture, turnover, and mechanical properties in middle-aged ovariectomized (OVX) rats. Female rats were sham-operated (n = 39, 13/group) or OVX (n = 143, 13/group). Sham-control and OVX-control rats (n = 39) receiving no GTP were assigned for sample collection at baseline, 3, or 6 months. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0489-y
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0489-yDOI Listing
November 2018
7 Reads

Association of Serum Sclerostin with Bone Sclerostin in Chronic Kidney Disease is Lost in Glucocorticoid Treated Patients.

Calcif Tissue Int 2018 Nov 7. Epub 2018 Nov 7.

Division of Renal Medicine and Baxter Novum, Karolinska University Hospital at Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.

The osteocytic protein sclerostin inhibits bone turnover. Serum sclerostin rises early in chronic kidney disease (CKD), but if this reflects osteocyte sclerostin production is unclear, since sclerostin is also expressed in extra-skeletal tissue. Glucocorticoid treatment impacts on serum sclerostin, but the effect on the association between serum and bone sclerostin is unknown. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0491-4
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0491-4DOI Listing
November 2018
2 Reads

Effect of Adding a Galacto-Oligosaccharides/Fructo-Oligosaccharides (GOS/FOS®) Mixture to a Normal and Low Calcium Diet, on Calcium Absorption and Bone Health in Ovariectomy-Induced Osteopenic Rats.

Calcif Tissue Int 2018 Nov 2. Epub 2018 Nov 2.

Metabolic Bone Diseases Laboratory, Clinical Hospital, Immunology, Genetic and Metabolism Institute (INIGEM), National Council for Scientific and Technologic Research (CONICET), Buenos Aires University (UBA), Av. Córdoba 2351-8vo. Piso (1120), Buenos Aires, Argentina.

Menopause is associated with bone loss. Prebiotics increase Ca, inorganic phosphorus (Pi), and Mg absorption, improving bone health. These increases would supply an extra amount of minerals, decreasing bone resorption and possibly reversing ovariectomy-induced bone loss. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0490-5
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0490-5DOI Listing
November 2018
4 Reads

Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis.

Calcif Tissue Int 2018 Oct 26. Epub 2018 Oct 26.

Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0486-1
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0486-1DOI Listing
October 2018
3 Reads
3.272 Impact Factor

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival.

Calcif Tissue Int 2018 Oct 24. Epub 2018 Oct 24.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, 1120 15th St, Augusta, GA, 30912, USA.

Osteocytes experience plasma membrane disruptions (PMD) that initiate mechanotransduction both in vitro and in vivo in response to mechanical loading, suggesting that osteocytes use PMD to sense and adapt to mechanical stimuli. PMD repair is crucial for cell survival; antioxidants (e.g. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0487-0
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0487-0DOI Listing
October 2018
1 Read

Reduction of Hip and Other Fractures in Patients Receiving Teriparatide in Real-World Clinical Practice: Integrated Analysis of Four Prospective Observational Studies.

Calcif Tissue Int 2018 Oct 20. Epub 2018 Oct 20.

Eli Lilly and Company, Indianapolis, IN, USA.

The phase 3 teriparatide Fracture Prevention Trial showed significant reductions in vertebral (VF) and nonvertebral (NVF) fractures; however, patient exposure was insufficient for full analysis of low-incidence fractures, including hip. We assessed fracture results in pooled data from four prospective, observational teriparatide studies. Ambulatory women and men with osteoporosis received subcutaneous teriparatide 20 µg/day for up to 24 months per routine clinical practice. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0485-2
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0485-2DOI Listing
October 2018
2 Reads

Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts.

Calcif Tissue Int 2018 Oct 19. Epub 2018 Oct 19.

Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa, 142-8555, Japan.

Nephronectin (Npnt), an extracellular matrix protein, is known to be a ligand of integrin α8β1, and it has also been known to play critical roles as various organs. In the present study, elevated extracellular inorganic phosphate (Pi) strongly inhibited the expression of Npnt in MC3T3-E1 cells, while the existence of extracellular calcium (Ca) was indispensable for its effect. Furthermore, Pi-induced inhibition of Npnt gene expression was recovered by inhibitors of both sodium-dependent Pi transporter (Pit) and fibroblast growth factor receptors (Fgfrs). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0484-3
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0484-3DOI Listing
October 2018
7 Reads

Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis.

Calcif Tissue Int 2018 Oct 10. Epub 2018 Oct 10.

School of Basic Medical Sciences, Central South University, 410000, Changsha, People's Republic of China.

Osteoporosis is a common metabolic bone disease. The impact of global blood plasma proteins on the risk of osteoporosis remains elusive now. We performed a large-scale polygenic risk score (PRS) analysis to evaluate the potential effects of blood plasma proteins on the development of osteoporosis in 2286 Caucasians, including 558 males and 1728 females. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0483-4DOI Listing
October 2018
4 Reads
3.272 Impact Factor

Pre-treatment with Pamidronate Improves Bone Mechanical Properties in Mdx Mice Treated with Glucocorticoids.

Calcif Tissue Int 2018 Oct 9. Epub 2018 Oct 9.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

Duchenne muscular dystrophy (DMD) is an X-linked disease of progressive muscle deterioration and weakness. Patients with DMD have poor bone health which is partly due to treatment with glucocorticoids, a standard therapy to prolong muscle function that also induces bone loss. Bisphosphonates are used to treat adults at risk of glucocorticoid-induced osteoporosis but are not currently used in DMD patients until after they sustain fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0482-5DOI Listing
October 2018
3 Reads

Bone Microstructure in Response to Vitamin D3 Supplementation: A Randomized Placebo-Controlled Trial.

Calcif Tissue Int 2018 Oct 6. Epub 2018 Oct 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus, Denmark.

Vitamin D supplementation is often used in the prevention and treatment of osteoporosis, but the role of vitamin D has lately been questioned. We aimed to investigate the effect of 3 months of daily vitamin D3 supplementation (70 µg [2800 IU] vs. placebo) initiated in winter months on bone health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0481-6DOI Listing
October 2018
2 Reads

Lack of Association Between Vitamin D and Hand Grip Strength in Asians: A Nationwide Population-Based Study.

Calcif Tissue Int 2018 Oct 3. Epub 2018 Oct 3.

Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Despite the beneficial role and plausible mechanism of vitamin D on skeletal muscle in animal studies, its association in humans remains a controversial issue due to inconsistent clinical results, especially in older Asians. This was a population-based, cross-sectional study from the Korea National Health and Nutrition Examination Surveys, which enrolled 354 men aged ≥ 50 years and 328 postmenopausal women. Hand grip strength (HGS) was measured using a digital grip strength dynamometer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0480-7DOI Listing
October 2018

Coexistence of Pre-sarcopenia and Metabolic Syndrome in Arab Men.

Calcif Tissue Int 2018 Sep 24. Epub 2018 Sep 24.

Prince Mutaib bin Abdullah Chair for Biomarkers Research on Osteoporosis, Department of Biochemistry, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Saudi Arabia.

Objective: The present single-center observational study determined the prevalence and coexistence of sarcopenia, pre-sarcopenia, and metabolic syndrome (MetS) among apparently healthy Arab men and whether having both conditions present a unique cardiometabolic profile that is distinct than having the conditions separately.

Methods: A total of 471 out of 530 Arab men aged 20-77 years old were included after screening for the presence of pre-sarcopenia (ALM/ht < 7.26 kg/m), sarcopenia (presence of both low muscle mass and low function), and MetS. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0477-2
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0477-2DOI Listing
September 2018
1 Read

Large Bone not Necessarily High Bone Mineral Density: Evidence from a National Survey.

Calcif Tissue Int 2018 Sep 22. Epub 2018 Sep 22.

Southeast Missouri State University, Cape Girardeau, USA.

There is scarcity of population-level data on the bone areal size (BA) that produces the highest bone mineral density (BMD), and how BA relates to BMD among racial groups. We use population-level data to estimate the BA that coincide with the highest BMD among racial groups in the United States. A total of 7425 participants, age 18-75 years, whose BA and BMD were measured in the United States National Health and Nutrition Examination Survey (NHANES) 2009-2014, were assessed in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0479-0DOI Listing
September 2018

Health Care Costs Associated With Muscle Weakness: A UK Population-Based Estimate.

Calcif Tissue Int 2018 Sep 22. Epub 2018 Sep 22.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

Sarcopenia and muscle weakness are responsible for considerable health care expenditure but little is known about these costs in the UK. To address this, we estimated the excess economic burden for individuals with muscle weakness regarding the provision of health and social care among 442 men and women (aged 71-80 years) who participated in the Hertfordshire Cohort Study (UK). Muscle weakness, characterised by low grip strength, was defined according to the Foundation for the National Institutes of Health criteria (men < 26 kg, women < 16 kg). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0478-1
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0478-1DOI Listing
September 2018
11 Reads

OFELIA: Prevalence of Osteoporosis in Fragility Fracture Patients.

Calcif Tissue Int 2018 Sep 17. Epub 2018 Sep 17.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.

Worldwide, a care gap has been recognized between presenting with a fracture and prevention of the next fracture. Fracture Liaison Service is the most cost-effective method to close this gap, but its implementation is sparse in the Nordic countries. To assess the need for a fracture prevention program, the primary aim of this study was to estimate the prevalence of osteoporosis in patients treated for fragility fractures at Aarhus University Hospital, Denmark. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0476-3DOI Listing
September 2018
1 Read

Longitudinal Examination of Bone Loss in Male Rats After Moderate-Severe Contusion Spinal Cord Injury.

Calcif Tissue Int 2018 Sep 14. Epub 2018 Sep 14.

Research Service, Malcom Randall Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, 1601 SW Archer Road, Research 151, Gainesville, FL, 32608, USA.

To elucidate mechanisms of bone loss after spinal cord injury (SCI), we evaluated the time-course of cancellous and cortical bone microarchitectural deterioration via microcomputed tomography, measured histomorphometric and circulating bone turnover indices, and characterized the development of whole bone mechanical deficits in a clinically relevant experimental SCI model. 16-weeks-old male Sprague-Dawley rats received T laminectomy (SHAM, n = 50) or moderate-severe contusion SCI (n = 52). Outcomes were assessed at 2-weeks, 1-month, 2-months, and 3-months post-surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0471-8DOI Listing
September 2018
1 Read
3.270 Impact Factor

Vitamin D and Bone Mineral Density in HIV Newly Diagnosed Therapy-Naive Patients Without Any Secondary Causes of Osteoporosis.

Calcif Tissue Int 2018 Sep 12. Epub 2018 Sep 12.

Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile.

Bone loss and vitamin D deficiency are common in HIV patients. However, bone health status in newly diagnosed HIV patients has not been thoroughly described. Our aim was to assess the bone mineral density (BMD), bone resorption and vitamin D status in newly diagnosed HIV patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0474-5DOI Listing
September 2018
1 Read

Circulating Levels of Inflammation and the Effect on Exercise-Related Changes in Bone Mass, Structure and Strength in Middle-Aged and Older Men.

Calcif Tissue Int 2018 Sep 12. Epub 2018 Sep 12.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Geelong, Melbourne, VIC, 3215, Australia.

Chronic, low-grade systematic inflammation has been associated with bone loss and increased fracture risk. We previously reported that exercise improved femoral neck bone mineral density (BMD), geometry and strength and lumbar spine trabecular BMD in middle-aged and older men, but had no effect on markers of inflammation. The aim of this study was to examine the association between basal inflammatory status and the adaptive skeletal responses to exercise. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0475-4DOI Listing
September 2018

A Mild Inhibition of Cathepsin K Paradoxically Stimulates the Resorptive Activity of Osteoclasts in Culture.

Calcif Tissue Int 2018 Sep 7. Epub 2018 Sep 7.

Department of Clinical Cell Biology, Vejle Hospital/Lillebaelt Hospital, Institute of Regional Health Research, University of Southern Denmark, 7100, Vejle, Denmark.

Cathepsin K (CatK) inhibition allows reducing bone resorption with specific advantages compared to the existing anti-osteoporosis drugs. Its clinical use appears even more promising with the recent development of ectosteric inhibitors. A confusing observation, however, is that a low dose of the active site CatK inhibitor odanacatib (ODN) was reported to decrease bone mineral density and increase serum levels of the bone resorption marker carboxy-terminal collagen crosslinks (CTX). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0472-7
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0472-7DOI Listing
September 2018
8 Reads

Atrophic Gastritis as a Risk Factor for Bone Loss in Premenopausal Women in Their 40s: A Retrospective Cohort Study.

Calcif Tissue Int 2018 Sep 6. Epub 2018 Sep 6.

Department of Family Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 130 Dongduk-ro, Jung-gu, Daegu, 41944, South Korea.

This study assessed the effects of atrophic gastritis on bone mineral density (BMD) in premenopausal women in their 40s. We performed a retrospective analysis of medical records of premenopausal women in their 40s who underwent a health checkup, esophagogastroduodenoscopy, and bone densitometry at least thrice, 24 months apart, between January 2006 and December 2016. Based on first-visit esophagogastroduodenoscopy results, patients were divided into atrophic and non-atrophic gastritis groups; BMD changes over time were analyzed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0473-6
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0473-6DOI Listing
September 2018
3 Reads

Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling.

Calcif Tissue Int 2018 Sep 6. Epub 2018 Sep 6.

College of Life Science, Hebei Normal University, Shijiazhuang, 050051, China.

It has been found that iron disorder may lead to osteoporosis. However, the mechanism has been little explored. In the present study, we try to investigate the effects of iron disorder on bone metabolism using Irp2 knockout (Irp2) mice. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0469-2
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0469-2DOI Listing
September 2018
5 Reads

Bone Mass Development in Childhood and Its Association with Physical Activity and Vitamin D Levels. The CHAMPS-Study DK.

Calcif Tissue Int 2018 Sep 3. Epub 2018 Sep 3.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000, Odense C, Denmark.

This longitudinal study examined associations of bone mass with physical activity and vitamin D level over more than 6 years through puberty. A total of 663 participants (320 boys) with mean age 9.6 years at baseline (10-17 years at follow-up), underwent dual energy X-ray absorptiometry, anthropometry and blood samples for vitamin D at least twice during the study period (with three possible time-points). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0466-5
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0466-5DOI Listing
September 2018
5 Reads

Metacarpal Indices and Their Association with Fracture in South African Children and Adolescents.

Calcif Tissue Int 2018 Aug 22. Epub 2018 Aug 22.

South African MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, South Africa.

This prospective study assessed whether metacarpal indices predict fracture risk in children and adolescents. Radiogrammetry was performed at the second metacarpal midshaft on annual hand-wrist radiographs of 359 South African (SA) children aged 10-17 years. Bone length, bone width, and medullary width were measured, and the following proxies for bone strength calculated: metacarpal index (MCI), bone mineral density (BMD), section modulus (SM), stress-strain index (SSI), and slenderness index (SLI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0467-4DOI Listing
August 2018
1 Read

Metformin Alleviates the Bone Loss Induced by Ketogenic Diet: An In Vivo Study in Mice.

Calcif Tissue Int 2018 Aug 22. Epub 2018 Aug 22.

Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.

Metformin (Met), an anti-diabetes drug, has also shown therapeutic effects for ovariectomy-induced (OVX) osteoporosis. However, similar effects against bone loss induced by a ketogenic diet (KD) have not been tested. This study was aimed to evaluate the microarchitectures and biomechanics of KD-induced osteoporosis with and without administration of Met, and compare the effect of Met on bone loss induced by KD with OVX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0468-3DOI Listing
August 2018
11 Reads

Elevated Red Blood Cell Distribution Width Is Associated with Morphometric Vertebral Fracture in Community-Dwelling Older Adults, Independent of Anemia, Inflammation, and Nutritional Status: The Korean Urban Rural Elderly (KURE) Study.

Calcif Tissue Int 2018 Aug 29. Epub 2018 Aug 29.

Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Elevated red blood cell distribution width (RDW), a simple measure of red blood cell size heterogeneity, has been associated with increased mortality and morbidity in the elderly population, which might reflect systemic inflammation and malnutrition. However, whether elevated RDW is associated with prevalent morphometric vertebral fracture (VF) in older adults has not been investigated. We examined 2127 individuals (mean age 71. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0470-9DOI Listing
August 2018
7 Reads

Characterization of a Novel Calcific Achilles Tendinopathy Model in Mice: Contralateral Tendinopathy Induced by Unilateral Tenotomy.

Calcif Tissue Int 2018 Dec 21;103(6):698-707. Epub 2018 Aug 21.

Department of Orthopaedics, The Third Affiliated Hospital of Southern Medical University, 183 West Zhongshan Avenue, Guangzhou, 510665, Guangdong, People's Republic of China.

Achilles tendinopathy is a significant clinical disease characterized by activity-related pain, focal movement limitation, and intratendinous imaging changes. However, treatment of Achilles tendinopathy has been based mainly on theoretical rationale and clinical experience because of its unclear underlying pathogenesis and mechanism. The purpose of the study was to develop a simple but reproducible overuse-induced animal model of Achilles tendinopathy in mice to better understand the underlying mechanism and prevent calcific Achilles tendinopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0465-6DOI Listing
December 2018
2 Reads

Cortical Bone Loss in a Spontaneous Murine Model of Systemic Lupus Erythematosus.

Calcif Tissue Int 2018 Dec 16;103(6):686-697. Epub 2018 Aug 16.

Department of Physiology and Skeletal Disorders Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Patients with systemic lupus erythematosus (SLE), a chronic inflammatory disease characterized by loss of T- and B-cell tolerance to autoantigens, are at increased risk for osteoporosis and fractures. Mice deficient in Fc gamma receptor IIb (FcγRIIB) exhibit spontaneous SLE and its restoration rescues the disease. To determine whether deleting FcγRIIB affects cortical bone mass and mechanical properties, we analyzed cortical bone phenotype of FcγRIIB knockouts at different ages. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0464-7
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0464-7DOI Listing
December 2018
6 Reads

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size.

Calcif Tissue Int 2018 Dec 14;103(6):675-685. Epub 2018 Aug 14.

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.

Hormonal changes during lactation are associated with profound changes in bone cell biology, such as osteocytic osteolysis, resulting in larger lacunae. Larger lacuna shape theoretically enhances the transmission of mechanical signals to osteocytes. We aimed to provide experimental evidence supporting this theory by comparing the mechanoresponse of osteocytes in the bone of lactating mice, which have enlarged lacunae due to osteocytic osteolysis, with the response of osteocytes in bone from age-matched virgin mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0463-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208961PMC
December 2018

Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass.

Calcif Tissue Int 2018 Dec 9;103(6):638-652. Epub 2018 Aug 9.

Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that PGC1α plays a role in skeletal homeostasis since aged PGC1α-deficient mice (PGC1α) display impaired bone structure. Micro-CT of the tibial mid-shaft showed a marked decrease of cortical thickness in PGC1α (- 11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0459-4DOI Listing
December 2018

Early Fracture Healing is Delayed in the Col1a2 Osteogenesis Imperfecta Murine Model.

Calcif Tissue Int 2018 Dec 3;103(6):653-662. Epub 2018 Aug 3.

Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Via Taramelli 3B, 27100, Pavia, Italy.

Osteogenesis imperfecta (OI) is a rare heritable skeletal dysplasia mainly caused by type I collagen abnormalities and characterized by bone fragility and susceptibility to fracture. Over 85% of the patients carry dominant mutations in the genes encoding for the collagen type I α1 and α2 chains. Failure of bone union and/or presence of hyperplastic callus formation after fracture were described in OI patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0461-xDOI Listing
December 2018
9 Reads

VWC2 Increases Bone Formation Through Inhibiting Activin Signaling.

Calcif Tissue Int 2018 Dec 3;103(6):663-674. Epub 2018 Aug 3.

Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

By a bioinformatics approach, we have identified a novel cysteine knot protein member, VWC2 (von Willebrand factor C domain containing 2) previously known as Brorin. Since Brorin has been proposed to function as a bone morphogenetic protein (BMP) antagonist, we investigated the binding of Brorin/VWC2 to several BMPs; however, none of the BMPs tested were bound to VWC2. Instead, the βA subunit of activin was found as a binding partner among transforming growth factor (TGF)-β superfamily members. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0462-9DOI Listing
December 2018
1 Read

Transcriptomic Data Identified Key Transcription Factors for Osteoporosis in Caucasian Women.

Calcif Tissue Int 2018 Dec 28;103(6):581-588. Epub 2018 Jul 28.

Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.

Osteoporosis is a prevalent bone metabolic disease, mainly caused by excessive bone resorption (by osteoclasts) over bone formation (by osteoblasts). Identifying the key transcription factors and understanding the regulatory network influencing osteoclastogenesis will be helpful to explore the potential biological mechanism for osteoporosis. In our study, peripheral blood monocyte (PBM) was used as a cell model for bone mineral density (BMD) research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0457-6DOI Listing
December 2018
7 Reads

The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus.

Calcif Tissue Int 2018 Dec 26;103(6):599-605. Epub 2018 Jul 26.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

Osteocalcin acts as an endocrine hormone to regulate energy homeostasis. Although several in vivo and in vitro studies suggest that osteocalcin is involved in chronic inflammation, the association between osteocalcin and chronic inflammation in humans is unknown. In this cross-sectional study, 246 patients with type 2 diabetes mellitus (T2DM) were recruited to investigate the association of bone turnover markers with chronic inflammation parameters such as high-sensitive C-reactive protein (hsCRP), ferritin, and leukocyte subtype counts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0460-yDOI Listing
December 2018
1 Read

Aortic Calcification is Associated with Five-Year Decline in Handgrip Strength in Older Women.

Calcif Tissue Int 2018 Dec 23;103(6):589-598. Epub 2018 Jul 23.

Sir Charles Gairdner Hospital Unit, Medical School, University of Western Australia, Nedlands, WA, Australia.

The objective of the study was to determine the association between AAC and neuromuscular function over 5 years. Participants in this study were ambulant women over 70 years old residing in Perth, Western Australia who participated in the Calcium Intake Fracture Outcomes Study, a randomised controlled trial of calcium supplementation. 1046 women (mean age = 74. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00223-018-0458-5
Publisher Site
http://dx.doi.org/10.1007/s00223-018-0458-5DOI Listing
December 2018
7 Reads

Deproteinization of Cortical Bone: Effects of Different Treatments.

Calcif Tissue Int 2018 Nov 18;103(5):554-566. Epub 2018 Jul 18.

Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.

Bone is a biological composite material having collagen and mineral as its main constituents. In order to better understand the arrangement of the mineral phase in bone, porcine cortical bone was deproteinized using different chemical treatments. This study aims to determine the best method to remove the protein constituent while preserving the mineral component. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0453-xDOI Listing
November 2018
14 Reads

Spatial Distribution of Microcracks in Osteoarthritic Femoral Neck: Influence of Osteophytes on Microcrack Formation.

Calcif Tissue Int 2018 Dec 18;103(6):617-624. Epub 2018 Jul 18.

INSERM UMR 1033, Université de Lyon, Lyon, France.

Osteophytes have been suggested to influence the bone mechanical properties. The aim of this study was to compare the microcrack density in osteophytes with that in the other parts of the osteoarthritic femoral neck (FN). The presence of microcracks was investigated in the ultra-distal FN and in the osteophytes in samples obtained during hip arthroplasty in 24 postmenopausal women aged 67 ± 10 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0456-7DOI Listing
December 2018
9 Reads

Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits.

Calcif Tissue Int 2018 Dec 17;103(6):625-637. Epub 2018 Jul 17.

St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.

Bone is formed by deposition of a collagen-containing matrix (osteoid) that hardens over time as mineral crystals accrue and are modified; this continues until bone remodeling renews that site. Pharmacological agents for osteoporosis differ in their effects on bone remodeling, and we hypothesized that they may differently modify bone mineral accrual. We, therefore, assessed newly formed bone in mature ovariectomized rabbits treated with the anti-resorptive bisphosphonate alendronate (ALN-100µ g/kg/2×/week), the anabolic parathyroid hormone (PTH (1-34)-15µ g/kg/5×/week), or the experimental anti-resorptive odanacatib (ODN 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-018-0455-8DOI Listing
December 2018
1 Read