5,699 results match your criteria Calcified tissue international[Journal]


Prevalence of Frailty in Older Men and Women: Cross-Sectional Data from the Geelong Osteoporosis Study.

Calcif Tissue Int 2020 Jul 2. Epub 2020 Jul 2.

Epi-Centre for Healthy Ageing, IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine , Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.

Few studies have investigated the prevalence of frailty in the Australian general population. This study determined the prevalence of frailty in a population-based sample of older adults and examined the relationship between frailty and comorbid conditions. Men (n = 347) and women (n = 360) aged ≥ 60 year from the Geelong Osteoporosis Study (GOS) were assessed between 2016-2019 and 2011-2014, respectively. Read More

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http://dx.doi.org/10.1007/s00223-020-00713-3DOI Listing

Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats.

Calcif Tissue Int 2020 Jun 30. Epub 2020 Jun 30.

Department of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Viale S. Venuta, 88100, Catanzaro, Italy.

C-peptide therapy protects against diabetic micro- and macrovascular damages and neuropatic complications. However, to date, the role of C-peptide in preventing diabetes-related bone loss has not been investigated. Our aim was to evaluate if C-peptide infusion improves bone quality in diabetic rats. Read More

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http://dx.doi.org/10.1007/s00223-020-00716-0DOI Listing

Three-Dimensional Microstructural Basis for Differential Occurrence of Subcapital versus Basicervical Hip Fractures in Men.

Calcif Tissue Int 2020 Jun 29. Epub 2020 Jun 29.

Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, 11000, Serbia.

We analyzed the bone microarchitecture of the subcapital and basicervical subregions of the femoral neck in men, to determine whether microarchitectural differences of cortical or trabecular bone can explain differential frequency of subcapital vs. basicervical fractures, especially in aged persons. The study sample encompassed twenty male proximal femora obtained during autopsy. Read More

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http://dx.doi.org/10.1007/s00223-020-00717-zDOI Listing

The Distinct Role of the Extra-Large G Protein ɑ-Subunit XLɑs.

Calcif Tissue Int 2020 Jun 28. Epub 2020 Jun 28.

Laboratory of Endocrinology and Metabolism, Department of Endocrinology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, China.

GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Read More

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http://dx.doi.org/10.1007/s00223-020-00714-2DOI Listing

Successful Intravascular Treatment of an Intraosseous Arteriovenous Fistula in Fibrous Dysplasia.

Calcif Tissue Int 2020 Jun 17. Epub 2020 Jun 17.

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD, 20892-4320, USA.

Fibrous dysplasia (FD) is a benign bone disease characterized by expansile lesions that typically stabilize with age. Rarely, FD can undergo malignant transformation, presenting with atypical, rapid growth and destruction of adjacent bone. Other potential causes of rapid FD expansion include secondary lesions, such as aneurysmal bone cysts. Read More

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http://dx.doi.org/10.1007/s00223-020-00712-4DOI Listing

New Therapies for Hypophosphatemia-Related to FGF23 Excess.

Calcif Tissue Int 2020 Jun 5. Epub 2020 Jun 5.

Department of Medicine Section of Endocrinology, Yale School of Medicine, PO Box 802080, New Haven, CT, 06520, USA.

FGF23 is a hormone produced by osteocytes in response to an elevation in the concentration of extracellular phosphate. Excess production of FGF23 by bone cells, or rarely by tumors, is the hormonal basis for several musculoskeletal syndromes characterized by hypophosphatemia due to renal phosphate wasting. FGF23-dependent chronic hypophosphatemia causes rickets and osteomalacia, as well as other skeletal complications. Read More

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http://dx.doi.org/10.1007/s00223-020-00705-3DOI Listing

Tumor-Induced Osteomalacia.

Calcif Tissue Int 2020 Jun 5. Epub 2020 Jun 5.

Skeletal Disorders and Mineral Homeostasis Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include hypophosphatemia due to renal phosphate wasting, inappropriately normal or frankly low 1,25-dihydroxy-vitamin D, and inappropriately normal or elevated FGF23. TIO is caused by typically small, slow growing, benign phosphaturic mesenchymal tumors (PMTs) that are located almost anywhere in the body from the skull to the feet, in soft tissue or bone. Read More

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http://dx.doi.org/10.1007/s00223-020-00691-6DOI Listing

The Predictive Value of Sarcopenia and Falls for 2-Year Major Osteoporotic Fractures in Community-Dwelling Older Adults.

Calcif Tissue Int 2020 May 30. Epub 2020 May 30.

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

To evaluate the associations of sarcopenia and previous falls with 2-year major osteoporotic fractures (MOFs) in community-dwelling older adults. Four thousand Chinese men and women ≥ 65 years recruited from Hong Kong communities were prospectively followed up. Measures of muscle mass, grip strength, gait speed and falls in the previous year were recorded at baseline, the 2nd year and the 4th year visit for each subject. Read More

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http://dx.doi.org/10.1007/s00223-020-00709-zDOI Listing

Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus.

Calcif Tissue Int 2020 May 28. Epub 2020 May 28.

Department of Nephrology and Endocrinology, Nordsjællands University Hospital, Hillerød, Denmark.

Preclinical studies have shown a potential osteoanabolic effect of metformin but human studies of how metformin affects bone turnover are few. A post hoc sub-study analysis of an 18-month multicenter, placebo-controlled, double-blinded trial in type 2 diabetes mellitus (T2DM), randomizing participants to metformin versus placebo both in combination with different insulin analogue regimens (Metformin + Insulin vs. Placebo + Insulin). Read More

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http://dx.doi.org/10.1007/s00223-020-00711-5DOI Listing
May 2020
3.272 Impact Factor

Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice.

Calcif Tissue Int 2020 May 27. Epub 2020 May 27.

Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine, Osakasayama, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.

Microgravity causes both muscle and bone loss. Although we previously revealed that gravity change influences muscle and bone through the vestibular system in mice, its detailed mechanism has not been elucidated. In this study, we investigated the roles of olfactomedin 1 (OLFM1), whose expression was upregulated during hypergravity in the soleus muscle, in mouse bone cells. Read More

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http://dx.doi.org/10.1007/s00223-020-00710-6DOI Listing

Unloading-Induced Cortical Bone Loss is Exacerbated by Low-Dose Irradiation During a Simulated Deep Space Exploration Mission.

Calcif Tissue Int 2020 May 25. Epub 2020 May 25.

INSERM U1059-SAINBIOSE, Université de Lyon, 10 rue de la Marandière, 42270, Saint-Priest-en-Jarez, France.

Spaceflight-induced bone losses have been reliably reproduced in Hind-Limb-Unloading (HLU) rodent models. However, a considerable knowledge gap exists regarding the effects of low-dose radiation and microgravity together. Ten-week-old male C57BL/6J mice, randomly allocated to Control (CONT), Hind-Limb Unloading (HLU), and Hind-Limb Unloading plus Irradiation (HLUIR), were acclimatized at 28 °C, close to thermoneutral temperature, for 28 days prior to the 14-day HLU protocol. Read More

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http://dx.doi.org/10.1007/s00223-020-00708-0DOI Listing

Bisphosphonate Therapy and Tooth Development in Children and Adolescents with Osteogenesis Imperfecta.

Calcif Tissue Int 2020 May 25. Epub 2020 May 25.

Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.

Osteogenesis imperfecta (OI) is a heterogeneous connective tissue disorder characterized by repeated fractures and skeletal disorders. At present, bisphosphonate (BP) therapy is the gold standard for OI treatment. The present retrospective study evaluated the effect of BP therapy on tooth development and eruption of permanent teeth in a cohort of children receiving pamidronate. Read More

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http://dx.doi.org/10.1007/s00223-020-00707-1DOI Listing

Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons.

Calcif Tissue Int 2020 May 21. Epub 2020 May 21.

Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Sunshine Hospital, L3 WCHRE Bldg, 176 Furlong Road, St Albans, VIC, 3021, Australia.

Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. Read More

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http://dx.doi.org/10.1007/s00223-020-00706-2DOI Listing
May 2020
3.272 Impact Factor

Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).

Calcif Tissue Int 2020 May 19. Epub 2020 May 19.

Reference Center for Inborn Errors of Metabolism, Pediatric Unit, University Hospital of Nancy, Nancy, France.

Vitamin D-dependent rickets type 1B (VDDR1B) is an autosomal semidominant genetic disorder caused by a deficiency in CYP2R1, which encodes vitamin D 25-hydroxylase, an enzyme that plays a crucial role in the conversion of vitamin D to 25-dihydroxyvitamin D. VDDR1B is a severe form of rickets that occurs during infancy and which is responsive to 25-OH vitamin D supplementation. We studied three adult patients from a multi-consanguineous family with VDDR1B. Read More

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http://dx.doi.org/10.1007/s00223-020-00704-4DOI Listing

Where Two Common Conditions of Aging Meet: Osteoarthritis and Sarcopenia.

Calcif Tissue Int 2020 May 18. Epub 2020 May 18.

Service de Rhumatologie et Pathologie Osseuse, Hôpital Edouard Herriot, 69437, Lyon cedex 03, France.

Osteoarthritis and sarcopenia are the most frequently described musculoskeletal disorders in older persons but the intertwining of these conditions and of their functional and cellular causes is complex. This narrative review aims to identify the links between osteoarthritis and sarcopenia described 1-in clinical studies, 2-in in vitro studies, and 3-the available treatment strategies for both conditions. Electronic databases were used for the literature search of all studies investigating the relationship between sarcopenia and the presence of concomitant osteoarthritis. Read More

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http://dx.doi.org/10.1007/s00223-020-00703-5DOI Listing

Congenital Conditions of Hypophosphatemia Expressed in Adults.

Calcif Tissue Int 2020 May 14. Epub 2020 May 14.

Bone Metabolic Diseases Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, AOU Careggi, Florence, Italy.

The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a congenital disorder of vitamin D metabolism characterized by osteomalacia and hypophosphatemia in adult patients. Hypophosphatemia in adults is defined as serum phosphate concentration < 0.80 mmol/L. Read More

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http://dx.doi.org/10.1007/s00223-020-00695-2DOI Listing

The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.

Calcif Tissue Int 2020 May 11. Epub 2020 May 11.

Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

Congruent, low-friction relative movement between the articulating elements of a synovial joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint formation or maintenance exist, mechanical overloading and osteoarthritis (OA) follow. The heritable component of OA accounts for ~ 50% of susceptible risk. Read More

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http://dx.doi.org/10.1007/s00223-020-00702-6DOI Listing

Osteoarthritis: Current Molecular Biomarkers and the Way Forward.

Calcif Tissue Int 2020 May 4. Epub 2020 May 4.

Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.

The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint survival-measures such as provided by imaging biomarkers, molecular biomarkers and joint replacement frequency, respectively. Although biomarkers supporting investigational drug use and drug approval include surrogate endpoints that may not necessarily reflect or directly correlate with the clinical outcome of interest, a formal biomarker qualification process currently exists that is a rigorous three stage process that yields biomarker approvals (or denials) for specific contexts of use. Read More

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http://dx.doi.org/10.1007/s00223-020-00701-7DOI Listing

The Association Between Muscle Mass and Strength in Relation to Bone Measures in a Paediatric Population: Sex-Specific Effects.

Calcif Tissue Int 2020 May 2. Epub 2020 May 2.

Faculty of Health, Deakin University, Geelong, VIC, Australia.

Post-puberty, bone mass displays clear sex-specific patterns. However, research has suggested that a sexual dimorphism in bone mass is evident in younger children and is likely attributable to differences in lean mass. Thus, we aimed to determine whether the association with both overall muscle mass and/or muscle strength was different between the sexes in a paediatric population. Read More

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http://dx.doi.org/10.1007/s00223-020-00699-yDOI Listing

The Use of Collagen-Induced Arthritis Animal Model on Studying Bone Metabolism.

Calcif Tissue Int 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Pharmacology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.

CIA is a well-studied animal model of autoimmune arthritis. It resembles rheumatoid arthritis as far as histopathological changes and molecular pathogenesis are concerned. CIA is induced by immunization with collagen type II in susceptible strains. Read More

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http://dx.doi.org/10.1007/s00223-020-00697-0DOI Listing

Age-Related Increases in Marrow Fat Volumes have Regional Impacts on Bone Cell Numbers and Structure.

Calcif Tissue Int 2020 Apr 30. Epub 2020 Apr 30.

Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, 176 Furlong Road, St. Albans, VIC, 3021, Australia.

The increasing levels of bone marrow fat evident in aging and osteoporosis are associated with low bone mass and attributed to reduced osteoblastogenesis. Local lipotoxicity has been proposed as the primary mechanism driving this reduction in bone formation. However, no studies have examined the correlation between high levels of marrow fat volumes and changes in local cellularity. Read More

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http://dx.doi.org/10.1007/s00223-020-00700-8DOI Listing

Do Older Adults with Low Muscle Mass or Strength, in the Presence of Obesity, Have an Increased Risk of Joint Replacement Over 13 Years?

Calcif Tissue Int 2020 Jul 28;107(1):10-17. Epub 2020 Apr 28.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13 years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7. Read More

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http://dx.doi.org/10.1007/s00223-020-00698-zDOI Listing

The lncRNA GAS5 Inhibits the Osteogenic Differentiation and Calcification of Human Vascular Smooth Muscle Cells.

Calcif Tissue Int 2020 Jul 28;107(1):86-95. Epub 2020 Apr 28.

Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping Area, Shenyang, People's Republic of China.

Vascular calcification (VC), which is associated with high cardiovascular morbidity and mortality in patients with chronic kidney disease, is promoted by the osteoblastic differentiation of vascular smooth muscle cells (VSMCs). The present study explored the functional roles and molecular mechanisms of the long noncoding RNA growth arrest-specific transcript 5 (GAS5) in VC. Our results indicated that GAS5 was clearly downregulated in calcified human aortic vascular smooth muscle cells (HASMCs). Read More

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http://dx.doi.org/10.1007/s00223-020-00696-1DOI Listing

A Rare Cause of Hypophosphatemia: Raine Syndrome Changing Clinical Features with Age.

Calcif Tissue Int 2020 Jul 27;107(1):96-103. Epub 2020 Apr 27.

Department of Pediatric Endocrinology and Diabetes, Marmara University School of Medicine, Istanbul, Turkey.

Raine Syndrome (RS) is caused by biallelic loss-of-function mutations in FAM20C gene and characterized by hypophosphatemia, typical facial and skeletal features. Subperiosteal bone formation and generalized osteosclerosis are the most common radiological findings. Here we present a new case with RS. Read More

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http://dx.doi.org/10.1007/s00223-020-00694-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222149PMC

Congenital Conditions of Hypophosphatemia in Children.

Authors:
Erik Allen Imel

Calcif Tissue Int 2020 Apr 23. Epub 2020 Apr 23.

Division of Endocrinology, Departments of Medicine and Pediatrics, Indiana University School of Medicine, 1120 West Michigan Street, Gatch Building Room 365, Indianapolis, IN, 46112, USA.

Great strides over the past few decades have increased our understanding of the pathophysiology of hypophosphatemic disorders. Phosphate is critically important to a variety of physiologic processes, including skeletal growth, development and mineralization, as well as DNA, RNA, phospholipids, and signaling pathways. Consequently, hypophosphatemic disorders have effects on multiple systems, and may cause a variety of nonspecific signs and symptoms. Read More

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http://dx.doi.org/10.1007/s00223-020-00692-5DOI Listing

A Case of a Heterozygous Inactivating CASR Variant with Adult-Onset Symptomatic Hypercalcemia Requiring Extensive Surgery.

Calcif Tissue Int 2020 Jul 19;107(1):104-108. Epub 2020 Apr 19.

Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.

We describe the case of an adult female patient with symptomatic familial hypocalciuric hypercalcemia requiring a step-wise therapeutic approach and the eventual need for a total parathyroidectomy and thyroidectomy to cure symptoms. Genetic analysis demonstrated a heterozygous R227L inactivating CASR gene variant, previously only described in neonatal severe hyperparathyroidism. Post-operative histology showed diffuse hyperplasia of all four parathyroid glands along with the presence of intrathyroidal parathyroid tissue. Read More

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http://dx.doi.org/10.1007/s00223-020-00693-4DOI Listing

Correction to: Identifying Scoliosis in Population‑Based Cohorts: Automation of a Validated Method Based on Total Body Dual Energy X‑ray Absorptiometry Scans.

Calcif Tissue Int 2020 Apr 18. Epub 2020 Apr 18.

Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.

In the original version of the article, the co-author would like to add to the acknowledgements section to highlight their funding stream (EPSRC). The revised acknowledgements is given below. Read More

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http://dx.doi.org/10.1007/s00223-020-00690-7DOI Listing

JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.

Calcif Tissue Int 2020 Jul 13;107(1):72-85. Epub 2020 Apr 13.

Department of Oncology and Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK.

Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation. Pharmacological manipulation of monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (2-AG), reduced skeletal tumour burden and osteolysis associated with osteosarcoma and advanced breast and prostate cancers. MM and hematopoietic, immune and bone marrow cells express high levels of type 2 cannabinoid receptor and osteoblasts secrete 2-AG. Read More

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http://dx.doi.org/10.1007/s00223-020-00689-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271071PMC

The Causes of Hypo- and Hyperphosphatemia in Humans.

Calcif Tissue Int 2020 Apr 13. Epub 2020 Apr 13.

Reference Center for Rare Disorders of Calcium and Phosphate Metabolism, Reference Center for Rare Genetic Bone Disorders, OSCAR Filière, Rheumatology Department, Cochin Hospital, AP-HP Centre-Paris University, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.

Phosphate homeostasis involves several major organs that are the skeleton, the intestine, the kidney, and parathyroid glands. Major regulators of phosphate homeostasis are parathormone, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, which respond to variations of serum phosphate levels and act to increase or decrease intestinal absorption and renal tubular reabsorption, through the modulation of expression of transcellular transporters at the intestinal and/or renal tubular level. Any acquired or genetic dysfunction in these major organs or regulators may induce hypo- or hyperphosphatemia. Read More

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http://dx.doi.org/10.1007/s00223-020-00664-9DOI Listing

Glucocorticoids Enhanced Osteoclast Autophagy Through the PI3K/Akt/mTOR Signaling Pathway.

Calcif Tissue Int 2020 Jul 9;107(1):60-71. Epub 2020 Apr 9.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.

Autophagy is an evolutionarily conserved dynamic process and present in variety of cells at basal levels to maintain homeostasis and to promote cell survival in response to stresses. The early bone loss with excessive glucocorticoids (GCs) was reported to be related with the extension of the life span of osteoclasts. However, the connection between GCs induced bone loss and osteoclast autophagy remains to be elucidated. Read More

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http://dx.doi.org/10.1007/s00223-020-00687-2DOI Listing

Phosphate Metabolism in Health and Disease.

Authors:
Munro Peacock

Calcif Tissue Int 2020 Apr 7. Epub 2020 Apr 7.

Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, 1120 W Michigan Street, CL365, Indianapolis, IN, 46202, USA.

Phosphorus, a 5A element with atomic weight of 31, comprises just over 0.6% of the composition by weight of plants and animals. Three isotopes are available for studying phosphorus metabolism and kinetics. Read More

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http://dx.doi.org/10.1007/s00223-020-00686-3DOI Listing

Medications as a Risk Factor for Fragility Hip Fractures: A Systematic Review and Meta-analysis.

Calcif Tissue Int 2020 Jul 7;107(1):1-9. Epub 2020 Apr 7.

Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Fragility hip fractures and their associated morbidity and mortality pose a global healthcare problem. Several pharmaceutical products have been postulated to alter bone architecture and contribute to fragility hip fractures. We searched four electronic databases from inception to September 2017. Read More

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http://dx.doi.org/10.1007/s00223-020-00688-1DOI Listing

Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene.

Calcif Tissue Int 2020 Jul 3;107(1):52-59. Epub 2020 Apr 3.

Departments of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8016, USA.

Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Colony Stimulating Factor 1 (CSF1) induces expression of the rate limiting enzyme required for S1P synthesis, sphingosine kinase 1 (SPHK1) in bone in vivo, and in osteoclasts in vitro. To study the mechanism of CSF1-induced SPHK1 gene expression, a 2608 bp fragment of the murine SPHK1 gene (- 2497 to + 111 bp relative to the transcription start site) was cloned and transfected into pZen cells (murine fibroblasts engineered to express c-fms). Read More

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http://dx.doi.org/10.1007/s00223-020-00685-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274855PMC

Are Bisphosphonates Associated with Adverse Metabolic and Cognitive Effects? A Study in Intact Rats and Rats Fed High-Fat High-Fructose Diet.

Calcif Tissue Int 2020 Jul 24;107(1):41-51. Epub 2020 Mar 24.

Department of Pharmacology and Clinical Pharmacology and Therapeutics, Medical University of Varna, 55 Marin Drinov Str, 9002, Varna, Bulgaria.

Osteocalcin, known as a bone gla protein, is considered a regulator of energy metabolism and behavior in its undercarboxylated form (ucOC). Antiresorptive drugs, such as alendronate, reduce serum level of ucOC. The purpose of the current study was to verify if alendronate might impact on energy metabolism and animal behavior by reducing ucOC level and to find out if the presence of metabolic alterations would further worsen these potential adverse effects. Read More

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http://dx.doi.org/10.1007/s00223-020-00684-5DOI Listing

HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway.

Calcif Tissue Int 2020 May 18;106(5):518-532. Epub 2020 Mar 18.

Department of Joint Surgery, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, No.183 West Zhongshan Road, Tianhe District, Guangzhou, 510630, Guangdong, China.

Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was examined by CCK8 assay and Edu staining. Read More

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http://dx.doi.org/10.1007/s00223-020-00660-zDOI Listing
May 2020
3.272 Impact Factor

Urban-Rural Differences in Bone Mineral Density and its Association with Reproductive and Menstrual Factors Among Older Women.

Calcif Tissue Int 2020 Jun 16;106(6):637-645. Epub 2020 Mar 16.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.

Purpose: This study aimed to compare the bone mineral density (BMD) of older women living in rural and urban areas, and evaluate the potential factors affecting the risk of osteoporosis.

Methods: We recruited 574 women aged 65 years or older from rural areas and 496 from urban areas in Shanghai, China. The BMD values of the lumbar vertebrae and total left hip were measured by a dual energy X-ray absorptiometry densitometer. Read More

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http://dx.doi.org/10.1007/s00223-020-00681-8DOI Listing
June 2020
3.272 Impact Factor

Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients.

Calcif Tissue Int 2020 Jun 13;106(6):591-598. Epub 2020 Mar 13.

Section of Hematology and Coagulation, Department of Internal Medicine, Institute of Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy,, University of Gothenburg, Bruna Stråket 5, 413 45, Gothenburg, Sweden.

Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort study of adult Swedish lymphoma patients (n = 37,236), diagnosed 1995-2015 and compared with the entire Swedish population during the same period. Read More

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http://dx.doi.org/10.1007/s00223-020-00674-7DOI Listing

Distribution of Prevalent and Incident Vertebral Fractures and Their Association with Bone Mineral Density in Postmenopausal Women in the Teriparatide Versus Risedronate VERO Clinical Trial.

Calcif Tissue Int 2020 Jun 10;106(6):646-654. Epub 2020 Mar 10.

Department of Medical Research, Eli Lilly and Company, Avda. de la Industria 30, 28108, Alcobendas (Madrid), Spain.

Vertebral fractures (VFx) occur most frequently in the mid-thoracic and thoraco-lumbar regions, which experience the highest mechanical loading along the spine. The prevalence and incidence of VFx by their location and severity, and their relationship with bone mineral density (BMD), are seldom reported in randomized clinical trial cohorts. The VERO trial randomized 1360 postmenopausal women with at least two moderate or one severe VFx to receive either teriparatide or risedronate for up to 24 months. Read More

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http://dx.doi.org/10.1007/s00223-020-00683-6DOI Listing

Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss.

Calcif Tissue Int 2020 Jun 5;106(6):655-664. Epub 2020 Mar 5.

Institute of Musculoskeletal Medicine, University Münster, Münster, Germany.

Enhanced osteoclast formation and function is a fundamental cause of alterations to bone structure and plays an important role in several diseases impairing bone quality. Recent work revealed that TRP calcium channels 3 and 6 might play a special role in this context. By analyzing the bone phenotype of TRPC6-deficient mice we detected a regulatory effect of TRPC3 on osteoclast function. Read More

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http://dx.doi.org/10.1007/s00223-020-00673-8DOI Listing

Self-perceived Fracture Risk in the Global Longitudinal Study of Osteoporosis in Women: Its Correlates and Relationship with Bone Microarchitecture.

Calcif Tissue Int 2020 Jun 5;106(6):625-636. Epub 2020 Mar 5.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

The purpose of this study is to examine correlates of self-perceived fracture risk (SPR) and relationships between SPR and subsequent bone density and microarchitecture in the UK arm of the Global Longitudinal Study of Osteoporosis in Women. 3912 women completed baseline questionnaires detailing medical history and SPR; 492 underwent HRpQCT scans of the radius and tibia and DXA scans of total body, hip, femoral neck and lumbar spine a median of 7.5 years later. Read More

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http://dx.doi.org/10.1007/s00223-020-00680-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188698PMC

Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice.

Calcif Tissue Int 2020 Jul 5;107(1):31-40. Epub 2020 Mar 5.

Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden.

Epidemiological studies have shown that high bone mineral density (BMD) is associated with an increased risk of osteoarthritis (OA), but the causality of this relationship remains unclear. Both bone mass and OA have been associated with the WNT signaling pathway in genetic studies, there is thus an interest in studying molecular partners of the WNT signaling pathway and OA. Female mice overexpressing WNT16 in osteoblasts (Obl-Wnt16 mice) have an increased bone mass. Read More

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http://dx.doi.org/10.1007/s00223-020-00682-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270053PMC

Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study.

Calcif Tissue Int 2020 Jun 3;106(6):616-624. Epub 2020 Mar 3.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917 Health, Aging and Body Composition Study participants (aged 70-79 years). Read More

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http://dx.doi.org/10.1007/s00223-020-00679-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188697PMC

Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis.

Calcif Tissue Int 2020 Jul 27;107(1):18-30. Epub 2020 Feb 27.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Palagi 1, 50139, Florence, Italy.

Skeletal muscle has remarkable regenerative abilities regulated by a highly orchestrated process involving the activation of cellular and molecular responses, which are dependent on satellite cells. These cells maintain the stem cell population and provide numerous myogenic cells that proliferate, differentiate, fuse and lead to new myofiber formation for a functional contractile tissue. We have isolated and characterized satellite cells obtained from human biopsies and established an in vitro model of myogenesis, evaluating muscle regeneration, monitoring the dynamic increases of the specific myogenic regulatory factors and the final formation of multinucleated myofibers. Read More

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http://dx.doi.org/10.1007/s00223-020-00678-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271047PMC
July 2020
3.272 Impact Factor

Exosomes Secreted by Young Mesenchymal Stem Cells Promote New Bone Formation During Distraction Osteogenesis in Older Rats.

Calcif Tissue Int 2020 May 26;106(5):509-517. Epub 2020 Feb 26.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Rd 600, Shanghai, 200233, China.

Distraction osteogenesis (DO) is a clinically effective procedure to regenerate large bone defects. However, the treatment duration is undesirably lengthy, especially in elderly patients. Exosomes derived from mesenchymal stem cells (MSC-Exos) could exert the beneficial effects while avoiding the possible complications of stem cell transplantation. Read More

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http://dx.doi.org/10.1007/s00223-019-00656-4DOI Listing

Clinical Significance of Hypophosphatasemia in Children.

Calcif Tissue Int 2020 Jun 22;106(6):608-615. Epub 2020 Feb 22.

Division of Endocrinology, Department of Pediatrics, Marmara University School of Medicine, Istanbul, Turkey.

Low serum alkaline phosphatase (sALP)-hypophosphatasemia-is a characteristic of hypophosphatasia (HPP), but related to several clinical conditions. Here, we evaluated the frequency, persistency and the etiology of hypophosphatasemia in children. In retrospective analyses of sALP measurements from children, evaluated according to in-house constructed age- and sex-specific reference ranges, patients with no normal sALP measurement (Unresolved hypophosphatasemia) were invited for reanalysis. Read More

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http://dx.doi.org/10.1007/s00223-020-00677-4DOI Listing

Hyponatremia, Hypokalemia, and Fragility Fractures in Old Patients: More than an Association?

Calcif Tissue Int 2020 Jun 19;106(6):599-607. Epub 2020 Feb 19.

Gerontology Section, Department of Medical Science, University of Torino, Corso Bramante 88/90, 10126, Torino, Italy.

Purpose: Hyponatremia and hypokalemia are common among elderly and have been associated with osteoporosis, we evaluate the role of these electrolytes as risk for fragility fractures.

Methods: This study is divided in two parts: one retrospective and one prospective. We retrospectively collected data on urgently admitted patients for femoral fragility fractures (Fx) or for acute myocardial infarction (AMI), and patients admitted for elective hip/knee replacement surgery for osteoarthrosis (OA). Read More

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http://dx.doi.org/10.1007/s00223-020-00675-6DOI Listing

High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model.

Calcif Tissue Int 2020 Jun 19;106(6):665-677. Epub 2020 Feb 19.

Department of Pharmacology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.

Hypophosphatasia (HPP) is a systemic skeletal disease caused by mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNALP). We recently reported that survival of HPP model mice can be prolonged using an adeno-associated virus (AAV) vector expressing bone-targeted TNALP with deca-aspartate at the C terminus (TNALP-D); however, abnormal bone structure and hypomineralization remained in the treated mice. Here, to develop a more effective and clinically applicable approach, we assessed whether transfection with TNALP-D expressing virus vector at a higher dose than previously used would ameliorate bone structure defects. Read More

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http://dx.doi.org/10.1007/s00223-020-00676-5DOI Listing
June 2020
3.272 Impact Factor

Models of Osteoarthritis: Relevance and New Insights.

Calcif Tissue Int 2020 Feb 15. Epub 2020 Feb 15.

School of Applied Sciences, Edinburgh Napier University, Sighthill Campus, Edinburgh, UK.

Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most common form of arthritis, characterised by degradation of the articular cartilage, formation of osteophytes, subchondral sclerosis, synovial inflammation and ultimate loss of joint function. Understanding the pathogenesis of OA and its multifactorial aetiology will lead to the development of effective treatments, which are currently lacking. Read More

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http://dx.doi.org/10.1007/s00223-020-00670-xDOI Listing
February 2020

Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study.

Calcif Tissue Int 2020 May 14;106(5):476-485. Epub 2020 Feb 14.

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China.

Previous studies indicated a positive effect of vitamin K2 (VK2) supplementation on bone turnover biomarkers and bone mineral density (BMD), but the doses varied, and few studies have focused on the difference between VK2 supplementation alone and in combination with calcium and vitamin D. The aim of this study was to explore a low and effective dose of VK2 for improving BMD, and to examine whether the co-supplementation of VK2, calcium and vitamin D would bring greater effects. In this trial, a total of 311 community-dwelling men and postmenopausal women aged 50 and 75 years were randomly assigned to four groups, receiving placebo, 50 µg/day, 90 µg/day or co-supplementation with calcium (500 mg/day) and vitamin D (10 µg/day) for 1 year. Read More

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http://dx.doi.org/10.1007/s00223-020-00669-4DOI Listing
May 2020
3.272 Impact Factor

Prospects for Therapies in Osteoarthritis.

Calcif Tissue Int 2020 Feb 13. Epub 2020 Feb 13.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK.

Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. Read More

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http://dx.doi.org/10.1007/s00223-020-00672-9DOI Listing
February 2020