Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats.
- Yasuto Shikida,
- Masahide Mizobuchi,
- Takashi Inoue,
- Toma Hamada,
- Hiroaki Ogata,
- Fumihiko Koiwa,
- Takanori Shibata
Calcif Tissue Int 2018 Jun 7. Epub 2018 Jun 7.
Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, Japan.
Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with CKD. However, the mechanisms underlying stimulation of FGF23 remain to be investigated. We examined whether hypercalcemia induced by continuous intravenous (CIV) calcium (Ca) infusion regulates FGF23 levels in normal rats (Normal) and 5/6 nephrectomized uremic rats (Nx). Read More