5,525 results match your criteria Calcified tissue international[Journal]


Paget's Disease of Long Bones: Microstructural Analyses of Historical Bone Samples.

Calcif Tissue Int 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Although Paget's disease of bone (PDB) is the second most common metabolic bone disease, there is only limited information about the microarchitecture of affected bones. Therefore, the aim of this study was to determine cortical and trabecular bone properties in clinically relevant locations by microcomputed tomography (µCT). Ten femora and ten tibiae affected by Paget's disease taken from the Natural History Museum Vienna were compared to 13 femora and 10 tibiae of non-affected body donors. Read More

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http://dx.doi.org/10.1007/s00223-019-00539-8DOI Listing
March 2019
3.272 Impact Factor

Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells.

Calcif Tissue Int 2019 Feb 26. Epub 2019 Feb 26.

Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

Previous studies suggested that advanced glycation end products (AGEs) and insulin-like growth factor-I (IGF-I) are involved in the mechanism of diabetes-induced sarcopenia. In this study, we examined effects of treatments with AGEs and/or IGF-I for 24 h on myogenic differentiation and apoptosis in mouse myoblastic C2C12 cells. Real-time PCR and Western blot were performed to investigate mRNA and protein expressions, and apoptosis was examined by using a DNA fragment detection ELISA kit. Read More

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http://dx.doi.org/10.1007/s00223-019-00537-wDOI Listing
February 2019
1 Read

Executive summary of the European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Calcif Tissue Int 2019 Mar;104(3):235-238

Prince Mutaib Chair for Biomarkers, College of Science, King Saud University, Riyadh, Saudi Arabia.

A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Kanis et al. in Osteoporos Int https://doi.org/10. Read More

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http://dx.doi.org/10.1007/s00223-018-00512-xDOI Listing

A Comprehensive Study of Bone Manifestations in Adult Gaucher Disease Type 1 Patients in Argentina.

Calcif Tissue Int 2019 Feb 21. Epub 2019 Feb 21.

IIFP, Universidad Nacional de La Plata, CONICET, Facultad de Ciencias Exactas, Departamento de Ciencias Biologicas, Calle 47 y 115-La Plata, 1900, Buenos Aires, Argentina.

Gaucher disease (GD) is the most prevalent lysosomal storage disease, and bone involvement is the most disabling condition. The aim of the present study was to evaluate bone involvement in adult patients with GD, using an observational cross-sectional study. Patients were evaluated using X-rays, bone densitometry (BMD), trabecular bone score (TBS), magnetic resonance imaging (MRI), and biochemical bone markers. Read More

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http://link.springer.com/10.1007/s00223-019-00536-x
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http://dx.doi.org/10.1007/s00223-019-00536-xDOI Listing
February 2019
1 Read

An Optimised Fracture Liaison Service Model: Maintained Diagnostic Sensitivity Despite Reduced Number of Diagnostic Tests Performed.

Calcif Tissue Int 2019 Feb 19. Epub 2019 Feb 19.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, G317, Aarhus N, 8200, Denmark.

Patients suffering a low-energy fracture are at high risk of subsequent fractures. Investigation of all fragility fracture patients above the age of 50 years is recommended in order to prevent further fractures. The aim of this study was to investigate alternative strategies including known risk factors (age, sex, and body weight) for selecting fracture patients for osteoporosis assessment and investigate how these strategies would affect the proportion of patients with osteoporosis identified and the number of patients referred for Dual X-ray Absorptiometry (DXA) compared with the original FLS strategy. Read More

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http://dx.doi.org/10.1007/s00223-019-00535-yDOI Listing
February 2019

Rare Inherited forms of Paget's Disease and Related Syndromes.

Calcif Tissue Int 2019 Feb 13. Epub 2019 Feb 13.

Howard Hughes Medical Institute and Department of Cell and Molecular Biology, St Jude's Children's Research Hospital, Memphis, TN, USA.

Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of the TNFRSF11A gene, encoding the receptor activator of nuclear factor kappa B (RANK), cause severe PDB-like disorders including familial expansile osteolysis, early-onset familial PDB and expansile skeletal hyperphosphatasia. Read More

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http://dx.doi.org/10.1007/s00223-019-00520-5DOI Listing
February 2019
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Calciotropic Hormones and the Prevalence of Vertebral Fractures in Chinese Postmenopausal Women with Vitamin D Insufficiency: Peking Vertebral Fracture Study.

Calcif Tissue Int 2019 Feb 8. Epub 2019 Feb 8.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, National Commission of Health, Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing, 100730, China.

This case-control study aimed to examine the effect of high serum parathyroid hormone (PTH) level, especially the effect of secondary hyperparathyroidism (SHPT) related to hypovitaminosis D, on bone metabolism and bone phenotypes. We included a total of 830 Chinese postmenopausal women aged ≥ 50 years with serum 25-hydroxyvitamin D (25(OH)D) level < 30 ng/ml, among whom 415 women had prevalent vertebral fractures (VFs) and others were age-matched controls. We measured serum levels of 25(OH)D, PTH and bone turnover markers (BTMs), which included C-terminal telopeptide of type I collagen (β-CTX), N-aminoterminal prepeptide of type I procollagen (P1NP) and osteocalcin (OC). Read More

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http://dx.doi.org/10.1007/s00223-019-00531-2DOI Listing
February 2019
4 Reads

Genetic Variation in RIN3 in the Belgian Population Supports Its Involvement in the Pathogenesis of Paget's Disease of Bone and Modifies the Age of Onset.

Calcif Tissue Int 2019 Feb 6. Epub 2019 Feb 6.

Center of Medical Genetics, University of Antwerp & Antwerp University Hospital, Prins Boudewijnlaan 43, Edegem, 2650, Antwerp, Belgium.

Paget's disease of bone (PDB) is a common, late-onset bone disorder characterized by focal increase of bone turnover. Mutations in the SQSTM1 gene are found in up to 40% of patients and recent GWAS have led to novel associations with several loci. RIN3, the candidate gene located at the associated 14q32 locus, has recently been studied in a British cohort to elucidate its contribution to the pathogenesis. Read More

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http://dx.doi.org/10.1007/s00223-019-00530-3DOI Listing
February 2019
2 Reads

Proof of Concept on Functionality Improvement of Mesenchymal Stem-Cells, in Postmenopausal Osteoporotic Women Treated with Teriparatide (PTH1-34), After Suffering Atypical Fractures.

Calcif Tissue Int 2019 Feb 6. Epub 2019 Feb 6.

Unidad de Gestión Clínica de Endocrinología y Nutrición, CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, RETICEF, 14004, Córdoba, Spain.

Osteoporosis long-term treatment with nitrogen-containing bisphosphonates, has been associated with uncommon adverse effects, as atypical femoral fractures (AFF). Thus, treatment with teriparatide (TPTD; fragment of human parathyroid hormone; PTH) has been proposed for such patients. Besides its anabolizing effect on bone, TPTD may affect stem-cell mobilization and expansion. Read More

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http://dx.doi.org/10.1007/s00223-019-00533-0DOI Listing
February 2019
1 Read

Camurati-Engelmann Disease.

Calcif Tissue Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

Camurati-Engelmann disease or progressive diaphyseal dysplasia is a rare autosomal dominant sclerosing bone dysplasia. Mainly the skull and the diaphyses of the long tubular bones are affected. Clinically, the patients suffer from bone pain, easy fatigability, and decreased muscle mass and weakness in the proximal parts of the lower limbs resulting in gait disturbances. Read More

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http://dx.doi.org/10.1007/s00223-019-00532-1DOI Listing
February 2019
1 Read

Genetic Disruption of Anoctamin 5 in Mice Replicates Human Gnathodiaphyseal Dysplasia (GDD).

Calcif Tissue Int 2019 Feb 2. Epub 2019 Feb 2.

Beijing Stomatological Hospital, Capital Medical University, Beijing, People's Republic of China.

Gnathodiaphyseal dysplasia (GDD; OMIM#166260) is a rare skeletal disorder which is mainly characterized by cemento-osseous lesions in mandibles, bone fragility, bowing and diaphyseal sclerosis of tubular bones. GDD is caused by point mutations in Anoctamin-5 (ANO5); however, the disease mechanisms remain unclear. Here we generated Ano5-knockout (KO) mice using a CRISPR/Cas 9 approach to study loss of function aspects of GDD mutations. Read More

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http://dx.doi.org/10.1007/s00223-019-00528-xDOI Listing
February 2019

Elevated Bone Remodeling Markers of CTX and P1NP in Addition to Sclerostin in Patients with X-linked Hypophosphatemia: A Cross-Sectional Controlled Study.

Calcif Tissue Int 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatrics, Kolding Hospital at Lillebaelt Hospital, Kolding, Denmark.

Aspects of bone remodeling have only been scarcely studied in X-linked hypophosphatemia (XLH). In this cross-sectional controlled study, we assessed biochemical indices of bone remodeling and sclerostin in 27 adult patients (median age 47 [range 24-79] years, 19 women, 8 men) with XLH matched with 81 healthy control subjects (1:3) with respect to age-, sex-, and menopausal status. Markers of bone resorption (carboxyterminal cross-linked telopeptide of type 1 collagen, CTX) and formation (N-terminal propeptide of type 1 procollagen, P1NP) were higher in XLH patients compared to controls (median [IQR] 810 [500-1340] vs 485 [265-715] ng/l and 90 [57-136] vs 49 [39-65] ug/l, respectively, both p < 0. Read More

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http://dx.doi.org/10.1007/s00223-019-00526-zDOI Listing
February 2019
1 Read

The Association of Vitamin D in Youth and Early Adulthood with Bone Mineral Density and Microarchitecture in Early Adulthood.

Calcif Tissue Int 2019 Feb 1. Epub 2019 Feb 1.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

This study aimed to describe the association of vitamin D status at different stages of growth with bone measures in adolescence and early adulthood. There were 415 participants followed from age 8 to 16, and 201 further followed to age 25. Areal bone mineral density (BMD) at the spine, hip and total body was measured by dual-energy X-ray absorptiometry at ages 16 and 25, and tibial and radial trabecular and cortical bone microarchitecture by high resolution peripheral quantitative computerised tomography at age 25. Read More

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http://dx.doi.org/10.1007/s00223-019-00529-wDOI Listing
February 2019

Prospective Follow-Up of Cortical Interruptions, Bone Density, and Micro-structure Detected on HR-pQCT: A Study in Patients with Rheumatoid Arthritis and Healthy Subjects.

Calcif Tissue Int 2019 Feb 1. Epub 2019 Feb 1.

Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands.

Objectives: The purpose of the study was to prospectively investigate change (repair or progression) in the number, surface area and volume of cortical interruptions, bone density (vBMD) and micro-structural parameters assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in finger joints of patients with rheumatoid arthritis (RA) treated with synthetic disease modifying anti-rheumatic drugs (sDMARDs) and/or biologic DMARDs (bDMARDs) over a 1-year follow-up period, and in comparison with healthy subjects (HS).

Methods: Thirty-two patients with RA (221 joints, 53% on bDMARDs) and 32 HS (117 joints) were assessed at baseline and after 1 year using semi-automatic analysis of HR-pQCT images. Mean changes (group level) and the proportion of joints (joint level) with changes beyond the least significant change were calculated. Read More

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http://dx.doi.org/10.1007/s00223-019-00523-2DOI Listing
February 2019

Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia.

Calcif Tissue Int 2019 Feb 1. Epub 2019 Feb 1.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan.

Patients with achondroplasia (ACH) require various medical interventions throughout the lifetime. Survey of health-related quality of life (HRQoL) in adult ACH patients is essential for the evaluation of treatment outcomes performed during childhood such as growth hormone administration and limb lengthening surgeries, but no study focused on the treatment strategy by analyzing HRQoL of ACH patients. The purpose of this study was to assess whether final height impacted on HRQoL and to evaluate what kinds of medical interventions were positively or negatively associated with HRQoL. Read More

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http://link.springer.com/10.1007/s00223-019-00518-z
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http://dx.doi.org/10.1007/s00223-019-00518-zDOI Listing
February 2019
2 Reads

Bone Turnover Markers in Men and Women with Impaired Fasting Glucose and Diabetes.

Calcif Tissue Int 2019 Jan 24. Epub 2019 Jan 24.

Deakin University, Geelong, Australia.

Bone turnover markers (BTMs) are reduced in diabetes, but whether BTM changes occur in impaired fasting glucose (IFG) is unknown. The aim of this study was to investigate whether BTMs are altered in IFG and diabetes compared to normoglycaemia. For men and women (n = 2222) in the Geelong Osteoporosis Study, IFG was defined as fasting plasma glucose (FPG) 5. Read More

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http://dx.doi.org/10.1007/s00223-019-00527-yDOI Listing
January 2019
1 Read

Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods.

Calcif Tissue Int 2019 Jan 23. Epub 2019 Jan 23.

Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Inorganic phosphate (Pi) is an essential nutrient for maintaining various biological functions, particularly during growth periods. Excess intake of dietary Pi increases the secretion of fibroblast growth factor 23 (FGF23) and parathyroid hormone to maintain plasma Pi levels. FGF23 is a potent phosphaturic factor that binds to the α-klotho/FGFR complex in the kidney to promote excretion of Pi into the urine. Read More

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http://dx.doi.org/10.1007/s00223-019-00525-0DOI Listing
January 2019
1 Read

Effects of High-Intensity Interval Running Versus Cycling on Sclerostin, and Markers of Bone Turnover and Oxidative Stress in Young Men.

Calcif Tissue Int 2019 Jan 23. Epub 2019 Jan 23.

Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON, L2S 3A1, Canada.

This study compared sclerostin's response to impact versus no-impact high-intensity interval exercise in young men and examined the association between exercise-induced changes in sclerostin and markers of bone turnover and oxidative stress. Twenty healthy men (22.3 ± 2. Read More

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http://dx.doi.org/10.1007/s00223-019-00524-1DOI Listing
January 2019
1 Read

Paget's Disease of Bone.

Calcif Tissue Int 2019 Jan 23. Epub 2019 Jan 23.

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites. As a result, bone pain, noticeable deformities, arthritis at adjacent joints, and fractures can occur. In a small proportion of cases neoplastic degeneration in osteosarcoma, or, less frequently, giant cell tumor has been also described at PDB sites. Read More

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http://dx.doi.org/10.1007/s00223-019-00522-3DOI Listing
January 2019
8 Reads

Interleukin-6 Inhibitor Suppresses Hyperalgesia Without Improvement in Osteoporosis in a Mouse Pain Model of Osteoporosis.

Calcif Tissue Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

The aim of this study was to evaluate skeletal pain associated with osteoporosis and examine the inhibitory effect of interleukin-6 (IL-6) on pain in ovariectomized (OVX) mice. The mechanism of osteoporotic pain in OVX mice was evaluated by examining pain-related behavior and immunohistochemistry. The effects of IL-6 receptor inhibitor (IL-6i) on these parameters were also assessed. Read More

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http://dx.doi.org/10.1007/s00223-019-00521-4DOI Listing
January 2019

Baseball and Softball Pitchers are Distinct Within-Subject Controlled Models for Exploring Proximal Femur Adaptation to Physical Activity.

Calcif Tissue Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA.

Within-subject controlled models in individuals who preferentially load one side of the body enable efficient exploration of the skeletal benefits of physical activity. There is no established model of physical activity-induced side-to-side differences (i.e. Read More

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http://dx.doi.org/10.1007/s00223-019-00519-yDOI Listing
January 2019
3.272 Impact Factor

Effect of Endogenous Parathyroid Hormone on Bone Geometry and Skeletal Microarchitecture.

Calcif Tissue Int 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Parathyroid hormone (PTH) has anabolic or catabolic effects on bones; however, the skeletal effect of endogenous PTH on cortical and trabecular bones is not yet clear. Therefore, we aimed to examine the effects of an excess and a deficiency of endogenous PTH on the lumbar spine trabecular bone score (TBS) and bone geometry using dual-energy X-ray absorptiometry. We retrospectively included 70 patients with primary hyperparathyroidism (PHPT), 26 patients with idiopathic or postoperative hypoparathyroidism (HypoPT), and 96 normal controls matched by age, sex, and body mass index. Read More

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http://link.springer.com/10.1007/s00223-019-00517-0
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http://dx.doi.org/10.1007/s00223-019-00517-0DOI Listing
January 2019
9 Reads

All-Trans Retinoic Acid Promotes Osteogenic Differentiation and Bone Consolidation in a Rat Distraction Osteogenesis Model.

Calcif Tissue Int 2019 Mar 11;104(3):320-330. Epub 2019 Jan 11.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Distraction osteogenesis (DO) is used to treat specific disorders associated with growth abnormalities and/or loss of bone stock secondary to trauma or disease. However, a high rate of complications and discomfort hamper its further application in clinical practice. Here, we investigated the effects of all-trans retinoic acid (ATRA) on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) and bone consolidation in a rat DO model. Read More

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http://link.springer.com/10.1007/s00223-018-0501-6
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http://dx.doi.org/10.1007/s00223-018-0501-6DOI Listing
March 2019
7 Reads

OPG is Required for the Postnatal Maintenance of Condylar Cartilage.

Calcif Tissue Int 2019 Jan 8. Epub 2019 Jan 8.

Maxillofacial Surgery, Xuzhou Stomatological Hospital, 130 Huaihaixi Rd, 221002, Xuzhou, Jiangsu, China.

Osteoprotegerin (OPG) is one of the protective factors of bony tissue. However, the function of OPG in cartilage tissues remains elusive. The aim of this study is to explore the function of OPG in the postnatal maintenance and the occurring of osteoarthritis (OA) of temporomandibular joint (TMJ) in the rodent models. Read More

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http://dx.doi.org/10.1007/s00223-018-00510-zDOI Listing
January 2019
2 Reads

Osteoporosis Changes Collagen/Apatite Orientation and Young's Modulus in Vertebral Cortical Bone of Rat.

Calcif Tissue Int 2018 Dec 26. Epub 2018 Dec 26.

Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.

This study revealed the distinguished changes of preferential orientation of collagen and apatite and Young's modulus in two different types of osteoporotic bones compared with the normal bone. Little is known about the bone material properties of osteoporotic bones; therefore, we aimed to assess material properties in osteoporotic bones. 66 female Sprague-Dawley rats were used. Read More

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http://dx.doi.org/10.1007/s00223-018-0508-zDOI Listing
December 2018
2 Reads

Normative Data for Lean Mass Using FNIH Criteria in an Australian Setting.

Calcif Tissue Int 2018 Dec 20. Epub 2018 Dec 20.

Deakin University, Geelong, Australia.

Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m for men and < 0.512 m for women. Read More

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http://dx.doi.org/10.1007/s00223-018-0506-1DOI Listing
December 2018
1 Read

Once-Weekly Teriparatide Treatment Prevents Microdamage Accumulation in the Lumbar Vertebral Trabecular Bone of Ovariectomized Cynomolgus Monkeys.

Calcif Tissue Int 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turnover, and collagen cross-linking in the lumbar vertebral trabecular bone of ovariectomized (OVX) cynomolgus monkeys. Female monkeys were divided into four groups (n = 18-20 per group): (1) SHAM group, (2) OVX group, (3) OVX with 1. Read More

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http://dx.doi.org/10.1007/s00223-018-0500-7DOI Listing
December 2018
7 Reads

Sitagliptin Alters Bone Composition in High-Fat-Fed Mice.

Calcif Tissue Int 2018 Dec 18. Epub 2018 Dec 18.

GEROM, UPRES EA 4658, UNIV Angers, SFR ICAT, Institut de Biologie en Santé - CHU, 4 rue Larrey, 49933, Angers, France.

Type 2 diabetes mellitus is recognized as a significant risk factor for fragility of bone. Among the newer anti-diabetic agents, dipeptidyl peptidase-4 inhibitors (DPP4i) have been reported to decrease the occurrence of bone fractures although the reason is unclear. The main aim of this study was to evaluate the impact of sitagliptin treatment on tissue bone strength and compositional parameters in the high-fat-fed mouse model. Read More

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http://link.springer.com/10.1007/s00223-018-0507-0
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http://dx.doi.org/10.1007/s00223-018-0507-0DOI Listing
December 2018
8 Reads

Annual Injection of Zoledronic Acid Improves Bone Status in Children with Cerebral Palsy and Rett Syndrome.

Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.

Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.

Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More

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http://dx.doi.org/10.1007/s00223-018-0505-2DOI Listing
December 2018
1 Read

Bone Marrow Transplantation for Treatment of the Col1a2 Osteogenesis Imperfecta Mouse Model.

Calcif Tissue Int 2018 Dec 8. Epub 2018 Dec 8.

Orthopaedic Research and Biotechnology Unit, Kids Research, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.

Bone marrow transplantation (BMT) of healthy donor cells has been postulated as a strategy for treating osteogenesis imperfecta (OI) and other bone fragility disorders. The effect of engraftment by tail vein injection and/or marrow ablation by 6 Gy whole body irradiation were tested in Col1a2 (OI) mice as a model of mild-moderate OI. Dual-emission X-ray absorptiometry, microCT, and 4-point bending were used to measure bone volume (BV), bone mineral density (BMD), and biomechanical strength. Read More

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http://dx.doi.org/10.1007/s00223-018-0504-3DOI Listing
December 2018
1 Read

Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca/Calmodulin-Dependent Protein Kinase II.

Calcif Tissue Int 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China.

Hyperglycemia induces osteoclastogenesis and bone resorption through complicated, undefined mechanisms. Ca/calmodulin-dependent protein kinase II (CaMKII) promotes osteoclastogenesis, and could be activated by hyperglycemia. Here, we investigated whether CaMKII is involved in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption. Read More

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http://dx.doi.org/10.1007/s00223-018-0499-9DOI Listing
December 2018
3 Reads

Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification.

Calcif Tissue Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA.

Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities of daily living and pain. While soft tissue injury is a prerequisite of developing HO, the exact molecular pathology leading to trauma-induced HO remains unknown. Through prior investigations aimed at identifying the causative factors of HO, it has been suggested that additional predisposing factors that favor ossification within the injured soft tissues environment are required. Read More

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http://dx.doi.org/10.1007/s00223-018-0502-5DOI Listing
December 2018
5 Reads

Association Between the Decline in Muscle Health and the Decline in Bone Health in Older Individuals from the SarcoPhAge Cohort.

Calcif Tissue Int 2019 Mar 3;104(3):273-284. Epub 2018 Dec 3.

World Health Organization Collaborating Center for the Public Health Aspects of Musculoskeletal Health and Aging, Department of Public Health Sciences, Epidemiology and Health Economics, University of Liège, CHU of Liège, B.23, Avenue Hippocrate, 13, 4000, Liège, Belgium.

The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the relationship between bone decline and muscle decline over 1 year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. Read More

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http://link.springer.com/10.1007/s00223-018-0503-4
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http://dx.doi.org/10.1007/s00223-018-0503-4DOI Listing
March 2019
3 Reads

Fracture Risk in Women with Dysglycaemia: Assessing Effects of Baseline and Time-Varying Risk Factors.

Calcif Tissue Int 2019 Mar 27;104(3):262-272. Epub 2018 Nov 27.

Deakin University, Geelong, VIC, 3220, Australia.

Although individuals with diabetes appear to have a higher fracture risk compared to those without diabetes, fracture risk in impaired fasting glucose (IFG) has not been thoroughly explored. This study determined associations between glycaemia status and fracture risk. Women (n = 575, aged 50 + years) enrolled in the Geelong Osteoporosis Study, were followed from baseline (1993-1997), to date of first fracture, death or December 31, 2010, whichever occurred first (median 13. Read More

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http://dx.doi.org/10.1007/s00223-018-0498-xDOI Listing
March 2019
5 Reads

Sequential Treatment with Eldecalcitol After PTH Improves Bone Mechanical Properties of Lumbar Spine and Femur in Aged Ovariectomized Rats.

Calcif Tissue Int 2019 Mar 22;104(3):251-261. Epub 2018 Nov 22.

Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan.

Parathyroid hormone (PTH) analogs have a powerful anabolic effect on bone and are used in the treatment of patients with severe osteoporosis. However, there are limitations to how long they can be safely administered. Withdrawal of PTH results in the cancelation of its effects, necessitating subsequent treatment to maintain the bone quantity and quality. Read More

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http://dx.doi.org/10.1007/s00223-018-0497-yDOI Listing
March 2019
12 Reads

Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading.

Calcif Tissue Int 2019 Mar 21;104(3):344-354. Epub 2018 Nov 21.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio - Coppito 2, 67100, L'aquila, Italy.

During mechanical unloading, endothelial cells reduce osteogenesis and increase bone resorption. Here we describe the feedback response of endothelial cells to unloaded osteoblasts. Primary endothelial cells, ex vivo mouse aortic rings and chicken egg yolk membranes were incubated with conditioned medium from mouse primary osteoblasts (OB-CM) subjected to unit gravity or simulated microgravity, to assess its effect on angiogenesis. Read More

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http://dx.doi.org/10.1007/s00223-018-0496-zDOI Listing
March 2019
22 Reads

Chronic Non-bacterial Osteomyelitis: A Review.

Calcif Tissue Int 2018 Nov 19. Epub 2018 Nov 19.

Department of Endocrinology, Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Chronic non-bacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disorder, with a prevalence of around one in a million patients. In the more severe form, it is referred to as chronic recurrent multifocal osteomyelitis (CRMO). We present the current knowledge on epidemiology, pathophysiology as well as diagnostic options and treatment regimens. Read More

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http://link.springer.com/10.1007/s00223-018-0495-0
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http://dx.doi.org/10.1007/s00223-018-0495-0DOI Listing
November 2018
14 Reads

Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Phenotype Markers in Primary Human Chondrocytes by a Calcium/Calmodulin Kinase 2-Dependent Mechanism.

Calcif Tissue Int 2019 Mar 19;104(3):331-343. Epub 2018 Nov 19.

Department of Medicine, School of Medicine, University of Auckland, Auckland, New Zealand.

Chondrocytes in osteoarthritis undergo a phenotype shift leading to increased production of cartilage-degrading enzymes. There are similarities between the phenotype of osteoarthritic chondrocytes and those of growth plate chondrocytes. Hydroxyapatite can promote chondrocyte differentiation in the growth plate. Read More

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http://dx.doi.org/10.1007/s00223-018-0494-1DOI Listing
March 2019
13 Reads

Bisphosphonates Use and Risk of Subtrochanteric and Diaphyseal Femur Fractures in Korea: Results from the National Claim Registry.

Calcif Tissue Int 2019 Mar 16;104(3):313-319. Epub 2018 Nov 16.

Department of Orthopaedic Surgery, School of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Although Asian with bisphosphonate has been considered to have higher risk of subtrochanteric and diaphyseal femur (ST/DF) fractures, the occurrence of those fractures has been still unclear in Asia. The purpose of this study was to investigate the incidence rate of ST/DF fractures among bisphosphonate users from nationwide database in South Korea. Using national health insurance claim database, we only included the bisphosphonate users who took bisphosphonate for the first time in 2008 and evaluated the incidence rate of ST/DF fracture from 2008 to 2013. Read More

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http://link.springer.com/10.1007/s00223-018-0493-2
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http://dx.doi.org/10.1007/s00223-018-0493-2DOI Listing
March 2019
15 Reads

Trabecular Bone Score (TBS) and Bone Metabolism in Patients Affected with Type 1 Neurofibromatosis (NF1).

Calcif Tissue Int 2019 Feb 12;104(2):207-213. Epub 2018 Nov 12.

Unit of Endocrinology and Metabolic Diseases, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

In patients with neurofibromatosis type 1 (NF1), decreased bone mineral density (BMD) and low levels of 25-hydroxy vitamin D3 (25OHD) have been reported. Recently, the trabecular bone score (TBS) measurement has been proposed as index of bone microarchitecture and fracture risk. In 74 NF1 patients (48 females, 26 males, age 41 ± 12), we measured TBS and investigated clinical stage, lifestyle, vitamin D, serum bone turnover markers, vertebral and femoral BMD. Read More

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http://dx.doi.org/10.1007/s00223-018-0488-zDOI Listing
February 2019
7 Reads

A Bibliometric Study of Authorship and Collaboration Trends Over the Past 30 Years in Four Major Musculoskeletal Science Journals.

Calcif Tissue Int 2019 Mar 11;104(3):239-250. Epub 2018 Nov 11.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

This study explored changes in bibliometric variables over the last 30 years for four major musculoskeletal science journals (BONE®), Calcified Tissue International® (CTI®), Journal of Bone and Mineral Research® (JBMR®), and Journal of Orthopaedic Research® (JOR®), with a specific focus on author gender. Bibliometric data were collected for all manuscripts in 1985 (BONE®, CTI®, JOR®), 1986 (JBMR®), 1995, 2005, and 2015; 2776 manuscripts met inclusion criteria. Manuscripts from Europe were more often published in BONE® or CTI®, while those from North America in JBMR® or JOR®. Read More

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http://dx.doi.org/10.1007/s00223-018-0492-3DOI Listing
March 2019
5 Reads

Effect of Long-Term Green Tea Polyphenol Supplementation on Bone Architecture, Turnover, and Mechanical Properties in Middle-Aged Ovariectomized Rats.

Calcif Tissue Int 2019 Mar 9;104(3):285-300. Epub 2018 Nov 9.

Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA.

We investigated the effects of 6-month green tea polyphenols (GTP) supplementation on bone architecture, turnover, and mechanical properties in middle-aged ovariectomized (OVX) rats. Female rats were sham-operated (n = 39, 13/group) or OVX (n = 143, 13/group). Sham-control and OVX-control rats (n = 39) receiving no GTP were assigned for sample collection at baseline, 3, or 6 months. Read More

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http://link.springer.com/10.1007/s00223-018-0489-y
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http://dx.doi.org/10.1007/s00223-018-0489-yDOI Listing
March 2019
18 Reads

Association of Serum Sclerostin with Bone Sclerostin in Chronic Kidney Disease is Lost in Glucocorticoid Treated Patients.

Calcif Tissue Int 2019 Feb 7;104(2):214-223. Epub 2018 Nov 7.

Division of Renal Medicine and Baxter Novum, Karolinska University Hospital at Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.

The osteocytic protein sclerostin inhibits bone turnover. Serum sclerostin rises early in chronic kidney disease (CKD), but if this reflects osteocyte sclerostin production is unclear, since sclerostin is also expressed in extra-skeletal tissue. Glucocorticoid treatment impacts on serum sclerostin, but the effect on the association between serum and bone sclerostin is unknown. Read More

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http://link.springer.com/10.1007/s00223-018-0491-4
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http://dx.doi.org/10.1007/s00223-018-0491-4DOI Listing
February 2019
10 Reads

Effect of Adding a Galacto-Oligosaccharides/Fructo-Oligosaccharides (GOS/FOS®) Mixture to a Normal and Low Calcium Diet, on Calcium Absorption and Bone Health in Ovariectomy-Induced Osteopenic Rats.

Calcif Tissue Int 2019 Mar 2;104(3):301-312. Epub 2018 Nov 2.

Metabolic Bone Diseases Laboratory, Clinical Hospital, Immunology, Genetic and Metabolism Institute (INIGEM), National Council for Scientific and Technologic Research (CONICET), Buenos Aires University (UBA), Av. Córdoba 2351-8vo. Piso (1120), Buenos Aires, Argentina.

Menopause is associated with bone loss. Prebiotics increase Ca, inorganic phosphorus (Pi), and Mg absorption, improving bone health. These increases would supply an extra amount of minerals, decreasing bone resorption and possibly reversing ovariectomy-induced bone loss. Read More

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http://link.springer.com/10.1007/s00223-018-0490-5
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http://dx.doi.org/10.1007/s00223-018-0490-5DOI Listing
March 2019
17 Reads

Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis.

Calcif Tissue Int 2019 Feb 26;104(2):115-129. Epub 2018 Oct 26.

Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Read More

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http://link.springer.com/10.1007/s00223-018-0486-1
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http://dx.doi.org/10.1007/s00223-018-0486-1DOI Listing
February 2019
10 Reads
3.272 Impact Factor

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival.

Calcif Tissue Int 2019 Feb 24;104(2):224-234. Epub 2018 Oct 24.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, 1120 15th St, Augusta, GA, 30912, USA.

Osteocytes experience plasma membrane disruptions (PMD) that initiate mechanotransduction both in vitro and in vivo in response to mechanical loading, suggesting that osteocytes use PMD to sense and adapt to mechanical stimuli. PMD repair is crucial for cell survival; antioxidants (e.g. Read More

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http://link.springer.com/10.1007/s00223-018-0487-0
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http://dx.doi.org/10.1007/s00223-018-0487-0DOI Listing
February 2019
3 Reads

Reduction of Hip and Other Fractures in Patients Receiving Teriparatide in Real-World Clinical Practice: Integrated Analysis of Four Prospective Observational Studies.

Calcif Tissue Int 2019 Feb 20;104(2):193-200. Epub 2018 Oct 20.

Eli Lilly and Company, Indianapolis, IN, USA.

The phase 3 teriparatide Fracture Prevention Trial showed significant reductions in vertebral (VF) and nonvertebral (NVF) fractures; however, patient exposure was insufficient for full analysis of low-incidence fractures, including hip. We assessed fracture results in pooled data from four prospective, observational teriparatide studies. Ambulatory women and men with osteoporosis received subcutaneous teriparatide 20 µg/day for up to 24 months per routine clinical practice. Read More

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http://link.springer.com/10.1007/s00223-018-0485-2
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http://dx.doi.org/10.1007/s00223-018-0485-2DOI Listing
February 2019
4 Reads

Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts.

Calcif Tissue Int 2019 Feb 19;104(2):201-206. Epub 2018 Oct 19.

Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa, 142-8555, Japan.

Nephronectin (Npnt), an extracellular matrix protein, is known to be a ligand of integrin α8β1, and it has also been known to play critical roles as various organs. In the present study, elevated extracellular inorganic phosphate (Pi) strongly inhibited the expression of Npnt in MC3T3-E1 cells, while the existence of extracellular calcium (Ca) was indispensable for its effect. Furthermore, Pi-induced inhibition of Npnt gene expression was recovered by inhibitors of both sodium-dependent Pi transporter (Pit) and fibroblast growth factor receptors (Fgfrs). Read More

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http://link.springer.com/10.1007/s00223-018-0484-3
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http://dx.doi.org/10.1007/s00223-018-0484-3DOI Listing
February 2019
14 Reads

Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis.

Calcif Tissue Int 2019 Feb 10;104(2):171-181. Epub 2018 Oct 10.

School of Basic Medical Sciences, Central South University, 410000, Changsha, People's Republic of China.

Osteoporosis is a common metabolic bone disease. The impact of global blood plasma proteins on the risk of osteoporosis remains elusive now. We performed a large-scale polygenic risk score (PRS) analysis to evaluate the potential effects of blood plasma proteins on the development of osteoporosis in 2286 Caucasians, including 558 males and 1728 females. Read More

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http://dx.doi.org/10.1007/s00223-018-0483-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368453PMC
February 2019
11 Reads
3.272 Impact Factor

Pre-treatment with Pamidronate Improves Bone Mechanical Properties in Mdx Mice Treated with Glucocorticoids.

Calcif Tissue Int 2019 Feb 9;104(2):182-192. Epub 2018 Oct 9.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

Duchenne muscular dystrophy (DMD) is an X-linked disease of progressive muscle deterioration and weakness. Patients with DMD have poor bone health which is partly due to treatment with glucocorticoids, a standard therapy to prolong muscle function that also induces bone loss. Bisphosphonates are used to treat adults at risk of glucocorticoid-induced osteoporosis but are not currently used in DMD patients until after they sustain fractures. Read More

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http://dx.doi.org/10.1007/s00223-018-0482-5DOI Listing
February 2019
4 Reads