79 results match your criteria Caffeine-Related Psychiatric Disorders


Mendelian Randomization Studies of Coffee and Caffeine Consumption.

Nutrients 2018 Sep 20;10(10). Epub 2018 Sep 20.

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, Bristol BS8 1TU, UK.

Habitual coffee and caffeine consumption has been reported to be associated with numerous health outcomes. This perspective focuses on Mendelian Randomization (MR) approaches for determining whether such associations are causal. Genetic instruments for coffee and caffeine consumption are described, along with key concepts of MR and particular challenges when applying this approach to studies of coffee and caffeine. Read More

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September 2018
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Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study.

Anesthesiology 2018 Nov;129(5):912-920

From the Departments of Anesthesia and Critical Care (R.F., L.W., J.P.Z., S.K., J.L.A., Z.X.) Neurobiology (A.P.F.), University of Chicago, Chicago, Illinois the Department of Anesthesia, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China (L.W.) the Cancer Center (J.P.Z.) the College of Medicine (S.K.), University of Illinois at Chicago, College of Medicine, Chicago, Illinois.

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: There are currently no drugs clinically available to reverse general anesthesia. We previously reported that caffeine is able to accelerate emergence from anesthesia in rodents. This study was carried out to test the hypothesis that caffeine accelerates emergence from anesthesia in humans. Read More

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November 2018
2 Reads

Controlling for caffeine in cardiovascular research: A critical review.

Int J Psychophysiol 2018 Nov 5;133:193-201. Epub 2018 Jul 5.

Department of Psychology, Virginia Polytechnic Institute and State University, 109 Williams Hall, Blacksburg, VA 24061, United States of America. Electronic address:

Caffeine, the most widely consumed drug in the world, exerts numerous effects on cardiovascular activity. Thus, it is important and advisable to control for caffeine consumption in studies examining caffeine and/or cardiovascular activity and reactivity. This paper 1) reviews the literature concerning caffeine's effects on cardiovascular parameters; 2) summarizes the widely varying protocols used to control for the drug in extant cardiovascular literature, and 3) provide guidelines for caffeine control procedures to minimize potentially confounding acute and withdrawal effects of the drug. Read More

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November 2018
1 Read

Adolescent habitual caffeine consumption and hemodynamic reactivity during rest, psychosocial stress, and recovery.

J Psychosom Res 2018 Jul 26;110:16-23. Epub 2018 Apr 26.

Reykjavík University, Iceland.

Objective: Most adolescents regularly consume caffeine. Whereas observational studies have suggested that coffee may be cardio-protective, pharmacological experimentation with adults shows that caffeine at dietary doses increases blood pressure, thereby implicating regular caffeine consumption as a potential source of harm for cardiovascular health. The present study was in response to the dearth of caffeine research among younger consumers. Read More

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July 2018
6 Reads

Caffeine-Related Deaths: Manner of Deaths and Categories at Risk.

Nutrients 2018 May 14;10(5). Epub 2018 May 14.

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Caffeine is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Read More

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May 2018
1 Read

Caffeine does not affect susceptibility to cortical spreading depolarization in mice.

J Cereb Blood Flow Metab 2018 04 13:271678X18768955. Epub 2018 Apr 13.

1 Neurovascular Research Laboratory, Department of Radiology, Harvard Medical School, 2348 Massachusetts General Hospital , Charlestown, MA, USA.

Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly headache. Here, we tested whether caffeine, known to alleviate or trigger headache after acute exposure or chronic use/withdrawal, respectively, modulates CSD. Read More

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April 2018
2 Reads

The negative impact of sugar-sweetened beverages on children's health: an update of the literature.

BMC Obes 2018 20;5. Epub 2018 Feb 20.

2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.

While sugar sweetened beverage (SSB) consumption has declined in the last 15 years, consumption of SSBs is still high among children and adolescents. This research synthesis updates a prior review on this topic and examines the evidence regarding the various health impacts of SSBs on children's health (overweight/obesity, insulin resistance, dental caries, and caffeine-related effects). We searched PubMed, CAB Abstracts and PAIS International to identify cross-sectional, longitudinal and intervention studies examining the health impacts of SSBs in children published after January 1, 2007. Read More

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February 2018
5 Reads

Caffeine Consumption Is Associated With Higher Level of Physical Activity in Japanese Women.

Int J Sport Nutr Exerc Metab 2018 Sep 23;28(5):474-479. Epub 2018 Jul 23.

2 National Institutes of Biomedical Innovation, Health and Nutrition.

Caffeine has been described as a sports performance-enhancing substance. However, it is unclear whether it can increase the level of physical activity (PA) in nonathletic individuals. This study investigates the relationship between daily caffeine consumption and (a) daily PA/fitness or (b) intervention-induced changes in PA in women and men. Read More

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September 2018
1 Read

Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor.

Oncotarget 2017 Jul;8(28):45190-45199

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.

Two recent investigations found serum lipid and energy metabolites related to aggressive prostate cancer up to 20 years prior to diagnosis. To elucidate whether those metabolomic profiles represent etiologic or tumor biomarker signals, we prospectively examined serum metabolites of prostate cancer cases by size and extent of primary tumors in a nested case-control analysis in the ATBC Study cohort that compared cases diagnosed with T2 (n = 71), T3 (n = 51), or T4 (n = 15) disease to controls (n = 200). Time from fasting serum collection to diagnosis averaged 10 years (range 1-20). Read More

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July 2017
9 Reads

Caffeine addiction: Need for awareness and research and regulatory measures.

Asian J Psychiatr 2017 Feb 4. Epub 2017 Feb 4.

Department of Psychiatry, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi 221005, India. Electronic address:

Caffeine consumption has been constantly growing in India especially among children and youngsters. Addictive potential of caffeine has long been reported, still there is lack of awareness about caffeine abuse in India. There is an intense need for appropriate public health regulatory measures and awareness about addictive potential & harms related to caffeine. Read More

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February 2017
10 Reads

Symptoms Attributed to Consumption of Caffeinated Beverages in Adolescents.

J Caffeine Res 2015 Dec;5(4):187-191

Division of Developmental Medicine, Boston Children's Hospital , Boston, Massachusetts.

Pediatric caffeine use has become increasingly prevalent. The American Academy of Pediatrics discourages caffeine use by children and adolescents due to its adverse impact on sleep and blood pressure. The objective of this study was to measure prevalence of physical and emotional symptoms related to caffeine consumption among adolescents receiving primary care. Read More

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December 2015
3 Reads

Differences in the resting-state fMRI global signal amplitude between the eyes open and eyes closed states are related to changes in EEG vigilance.

Neuroimage 2016 Jan 29;124(Pt A):24-31. Epub 2015 Aug 29.

Center for Functional Magnetic Resonance Imaging, University of California San Diego, La Jolla, CA, USA; Department of Radiology, University of California San Diego, La Jolla, CA, USA; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. Electronic address:

In resting-state functional connectivity magnetic resonance imaging (fcMRI) studies, measures of functional connectivity are often calculated after the removal of a global mean signal component. While the application of the global signal regression approach has been shown to reduce the influence of physiological artifacts and enhance the detection of functional networks, there is considerable controversy regarding its use as the method can lead to significant bias in the resultant connectivity measures. In addition, evidence from recent studies suggests that the global signal is linked to neural activity and may carry clinically relevant information. Read More

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January 2016
1 Read

Prediction of plasma caffeine concentrations in young adolescents following ingestion of caffeinated energy drinks: a Monte Carlo simulation.

Eur J Pediatr 2015 Dec 26;174(12):1671-8. Epub 2015 Jun 26.

Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Unlabelled: The fast-growing consumption of caffeinated energy drinks (CEDs) is linked to increasing reports of caffeine intoxication in adolescents. There is limited data available regarding plasma caffeine concentrations in this population after CED intake and the potential implications for caffeine-related toxicity. This study was an in silico population pharmacokinetic analysis of caffeine. Read More

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December 2015
9 Reads

Autopsy report for a caffeine intoxication case and review of the current literature.

J Toxicol Pathol 2015 Jan 7;28(1):33-6. Epub 2014 Dec 7.

Division of Forensic Pathology and Science, Unit of Social Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan.

Caffeine (1,3,7-trimethylxanthine) is a popular mild central nervous system stimulant found in the leaves, seeds and fruits of various plants and in foodstuffs such as coffee, tea, and chocolate, among others. Caffeine is widely used and is not associated with severe side effects when consumed at relatively low doses. Although rarely observed, overdoses can occur. Read More

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January 2015
1 Read

Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer.

Am J Clin Nutr 2015 May 11;101(5):1000-11. Epub 2015 Mar 11.

From the Nutritional Epidemiology Branch (KAG, EL, SCM, QX, NDF, and RS), the Biostatistics Branch (JNS), and the Occupational and Environmental Epidemiology Branch (W-YH), Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD; the Innovation Center for Biomedical Informatics and Department of Oncology, Georgetown University Medical Center, Washington, DC (SMB); Information Management Services Inc., Silver Spring, MD (XX); and the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London, United Kingdom (AJC).

Background: Coffee intake may be inversely associated with colorectal cancer; however, previous studies have been inconsistent. Serum coffee metabolites are integrated exposure measures that may clarify associations with cancer and elucidate underlying mechanisms.

Objectives: Our aims were 2-fold as follows: 1) to identify serum metabolites associated with coffee intake and 2) to examine these metabolites in relation to colorectal cancer. Read More

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May 2015
20 Reads

Arousal and the attentional network in panic disorder.

Hum Psychopharmacol 2014 Nov 14;29(6):599-603. Epub 2014 Oct 14.

Department of Psychiatry, University of Würzburg, Würzburg, Germany.

Although a great deal of information about the neurobiology of panic disorder is now available, there is a need for an updated etiological model integrating recent findings on the neurobiology of the arousal system and its relationship with higher cortical functions in panic disorder. The current mini-review presents psychophysiological, molecular biological/genetic and functional neuroimaging evidence for dysfunction in major arousal systems of the brain. Such dysfunction may influence the development of panic disorder by precipitating autonomic bodily symptoms and at the same time increasing vigilance to these sensations by modulating cortical attentional networks. Read More

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November 2014
8 Reads

Differential regulation of caffeine metabolism in Coffea arabica (Arabica) and Coffea canephora (Robusta).

Planta 2015 Jan 24;241(1):179-91. Epub 2014 Sep 24.

Nestlé R&D Center, 101 Av. Gustave Eiffel, Notre Dame D'Oé, BP 49716, 37097, Tours, France.

Caffeine is a metabolite of great economic importance, especially in coffee, where it influences the sensorial and physiological impacts of the beverage. Caffeine metabolism in the Coffea species begins with the degradation of purine nucleotides through three specific N-methyltransferases: XMT, MXMT and DXMT. A comparative analysis was performed to clarify the molecular reasons behind differences in caffeine accumulation in two Coffea species, namely Coffea arabica and Coffea canephora var. Read More

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January 2015
7 Reads

Caffeine Use Disorder: A Review of the Evidence and Future Implications.

Curr Addict Rep 2014 Sep;1(3):186-192

Department of Psychiatry and Behavioral Sciences, Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina, USA.

The latest edition of the Diagnostic and Statistical Manual (DSM-5) has introduced new provisions for caffeine-related disorders. Caffeine Withdrawal is now an officially recognized diagnosis, and criteria for caffeine use disorder have been proposed for additional study. caffeine use disorder is intended to be characterized by cognitive, behavioral, and physiological symptoms indicative of caffeine use despite significant caffeine-related problems, similar to other Substance Use Disorders. Read More

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September 2014
12 Reads

Evidence for anxiolytic effects of acute caffeine on anxiety-related behavior in male and female rats tested with and without bright light.

Behav Brain Res 2014 Sep 27;271:7-15. Epub 2014 May 27.

Department of Psychology, University of Canterbury, Christchurch 8140, New Zealand.

Male and female PVG/c rats were observed in an open field (OF) and an elevated plus maze (EPM) either with or without a bright light stressor (600-692 lx) following an intraperitoneal injection of saline, 25 or 50mg/kg of caffeine. One week later, the same rats were observed under the same drug and lighting conditions but in the opposite apparatus to that experienced earlier. Either the higher or both doses of caffeine decreased anxiety as indicated by increased OF rearing and decreased grooming, immobility and corner occupancy (in the presence of bright light). Read More

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September 2014
21 Reads

Review of the energy drink literature from 2013: findings continue to support most risk from mixing with alcohol.

Curr Opin Psychiatry 2014 Jul;27(4):263-8

Department of Epidemiology, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: In the field of caffeine research, interest in and concern for energy drink consumption have grown. Most caffeine-related research studies published in 2013 focused on energy drink consumption. This article reviews this literature. Read More

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July 2014
12 Reads

Caffeine Content Labeling: A Missed Opportunity for Promoting Personal and Public Health.

J Caffeine Res 2013 Sep;3(3):108-113

Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.

Current regulation of caffeine-containing products is incoherent, fails to protect consumers' interests, and should be modified in multiple ways. We make the case for one of the regulatory reforms that are needed: all consumable products containing added caffeine should be required by the Food and Drug Administration (FDA) to include caffeine quantity on their labels. Currently, no foods or beverages that contain caffeine are required to include caffeine content on their labels. Read More

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September 2013
1 Read

Caffeine Withdrawal and Dependence: A Convenience Survey Among Addiction Professionals.

J Caffeine Res 2013 Jun;3(2):67-71

Department of Psychology, American University , Washington, District of Columbia.

Aims: Caffeine withdrawal was included in the research appendix of the DSM-IV to encourage additional research to assist with determining its status for the next version of the manual. Caffeine dependence was not included because of a lack of empirical research at the time of publication. This study assessed the beliefs of addiction professionals about the clinical importance of caffeine withdrawal and dependence. Read More

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June 2013
22 Reads

"Clozapine makes me quite drowsy, so when I wake up in the morning those first cups of coffee are really handy": an exploratory qualitative study of excessive caffeine consumption among individuals with schizophrenia.

BMC Psychiatry 2014 Apr 16;14:116. Epub 2014 Apr 16.

Neami National, 247 - 249 Rosanna Road, 3084 Rosanna, VIC, Australia.

Background: Research has shown that individuals with schizophrenia use caffeine at higher rates than the general population; however, no qualitative research has been undertaken investigating problematic caffeine use and its effects on this population. This article explores the role of caffeine consumption in the lives of people with schizophrenia through a narrative analysis of the attitudes and beliefs associated with this practice, and how these, in turn, influence caffeine consumption.

Methods: A qualitative study was undertaken with individuals who had previously scored in either a 'moderate' or 'high' risk category for caffeine use on the Alcohol, Smoking and Substance Involvement Screening Tool (ASSIST). Read More

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April 2014
11 Reads

Acute caffeine administration effect on brain activation patterns in mild cognitive impairment.

J Alzheimers Dis 2014 ;41(1):101-12

Department of Mental Health and Psychiatry, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland.

Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in 17 individuals with mild cognitive impairment (MCI) compared to 17 age-matched healthy controls (HC). All individuals were regular caffeine consumers with an overnight abstinence and given 200 mg caffeine versus placebo tablets 30 minutes before testing. Read More

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January 2015
12 Reads

Energy drinks and caffeine-related adverse effects.

Authors:
Kent A Sepkowitz

JAMA 2013 Jan;309(3):243-4

Infectious Disease Service, Department of Medicine, Infection Control, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.

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January 2013
2 Reads

A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.

Sleep 2012 Jul 1;35(7):967-75. Epub 2012 Jul 1.

Queensland Institute of Medical Research, Brisbane, Australia.

Objectives: To identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia.

Design: A hypothesis-free, genome-wide association study.

Setting: Community-based sample of Australian twins from the Australian Twin Registry. Read More

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July 2012
14 Reads

The effect of caffeine on working memory load-related brain activation in middle-aged males.

Neuropharmacology 2013 Jan 21;64:160-7. Epub 2012 Jun 21.

School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.

Caffeine is commonly consumed in an effort to enhance cognitive performance. However, little is known about the usefulness of caffeine with regard to memory enhancement, with previous studies showing inconsistent effects on memory performance. We aimed to determine the effect of caffeine on working memory (WM) load-related activation during encoding, maintenance and retrieval phases of a WM maintenance task using functional magnetic resonance imaging (fMRI). Read More

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January 2013
29 Reads

Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.

Br J Pharmacol 2012 Nov;167(5):946-59

Neuropsychopharmacology Research Group, School of Pharmacy and Pharmaceutical Sciences & Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.

Concomitant consumption of caffeine with recreational psychostimulant drugs of abuse can provoke severe acute adverse reactions in addition to longer term consequences. The mechanisms by which caffeine increases the toxicity of psychostimulants include changes in body temperature regulation, cardiotoxicity and lowering of the seizure threshold. Caffeine also influences the stimulatory, discriminative and reinforcing effects of psychostimulant drugs. Read More

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November 2012
2 Reads

Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.

J Bone Miner Res 2012 Mar;27(3):563-74

Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells. Little is known about how osteocytic networks respond to physiological mechanical stimuli. In this study, we compared the mechanical sensitivity of osteocytic and osteoblastic networks under physiological-related fluid shear stress (0. Read More

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March 2012
1 Read

Coffee, caffeine, and risk of hospitalization for arrhythmias.

Perm J 2011 ;15(3):19-25

Context: Population study data about relations of coffee drinking to arrhythmia are sparse.

Objective: To study relations of coffee drinking to risk of cardiac arrhythmia in 130,054 persons with previous data about coffee habits.Design and Outcome Measure: We used Cox proportional hazards models with 8 covariates to study coffee-related risk in 3137 persons hospitalized for cardiac arrhythmia. Read More

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November 2011
3 Reads

Caffeine enhances real-world language processing: evidence from a proofreading task.

J Exp Psychol Appl 2012 Mar 10;18(1):95-108. Epub 2011 Oct 10.

Cognitive Science Team, U.S. Army NSRDEC, 15 Kansas Street, Natick, MA 01760, USA.

Caffeine has become the most prevalently consumed psychostimulant in the world, but its influences on daily real-world functioning are relatively unknown. The present work investigated the effects of caffeine (0 mg, 100 mg, 200 mg, 400 mg) on a commonplace language task that required readers to identify and correct 4 error types in extended discourse: simple local errors (misspelling 1- to 2-syllable words), complex local errors (misspelling 3- to 5-syllable words), simple global errors (incorrect homophones), and complex global errors (incorrect subject-verb agreement and verb tense). In 2 placebo-controlled, double-blind studies using repeated-measures designs, we found higher detection and repair rates for complex global errors, asymptoting at 200 mg in low consumers (Experiment 1) and peaking at 400 mg in high consumers (Experiment 2). Read More

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March 2012
1 Read

Caffeine-related atrial fibrillation.

Am J Ther 2010 Sep-Oct;17(5):e169-71

Section of Cardiology, Department of Medicine, Rosalind Franklin University of Medicine and Science/Chicago Medical School, North Chicago, IL, USA.

We present a case of caffeine-induced atrial fibrillation which spontaneously reverted to normal sinus rhythm. Caffeine is a methylxanthine alkaloid that can cause various supraventricular and ventricular arrhythmias. It is important to improve public awareness of the potential adverse effects of high consumption of caffeine-containing products as fatal and serious events can occur. Read More

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March 2011
6 Reads

The drink remains the same: implicit positive associations in high but not moderate or non-caffeine users.

Psychol Addict Behav 2010 Jun;24(2):274-81

Department of Psychology, University of Portsmouth, ortsmouth PO1 2DY, UnitedKingdom.

Research has demonstrated that high, but not low caffeine users exhibit an attentional bias to caffeine related stimuli. Separately, the Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998) has been used to investigate the valence of implicit cognitions to drugs with some contradictory findings, though no work has addressed this issue with respect to caffeine. Here, we examined whether attentional bias would be found in high and moderate caffeine users using a pictorial version of the dot-probe task. Read More

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June 2010
4 Reads

Genetics of caffeine consumption and responses to caffeine.

Psychopharmacology (Berl) 2010 Aug 9;211(3):245-57. Epub 2010 Jun 9.

Department of Psychiatry & Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Ave, MC 3077, Chicago, IL 60637, USA.

Rationale: Caffeine is widely consumed in foods and beverages and is also used for a variety of medical purposes. Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term effects of caffeine.

Objective: This paper reviews the literature on the genetics of caffeine from the following: (1) twin studies comparing heritability of consumption and of caffeine-related traits, including withdrawal symptoms, caffeine-induced insomnia, and anxiety, (2) association studies linking genetic polymorphisms of metabolic enzymes and target receptors to variations in caffeine response, and (3) case-control and prospective studies examining relationship between polymorphisms associated with variations in caffeine response to risks of Parkinson's and cardiovascular diseases in habitual caffeine consumers. Read More

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August 2010
4 Reads

Mountain Dew or mountain don't?: a pilot investigation of caffeine use parameters and relations to depression and anxiety symptoms in 5th- and 10th-grade students.

J Sch Health 2009 Aug;79(8):380-7

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Background: Caffeine, the only licit psychoactive drug available to minors, may have a harmful impact on students' health and adjustment, yet little is known about its use or effects on students, especially from a developmental perspective. Caffeine use in 5th- and 10th-grade students was examined in a cross-sectional design, and relations and potential mediators of caffeine use to depression and anxiety symptoms were investigated.

Methods: Children (n = 135) and adolescents (n = 79) completed a measure of naturalistic use of caffeinated and noncaffeinated beverages. Read More

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August 2009
3 Reads

Caffeinated energy drinks--a growing problem.

Drug Alcohol Depend 2009 Jan 21;99(1-3):1-10. Epub 2008 Sep 21.

Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

Since the introduction of Red Bull in Austria in 1987 and in the United States in 1997, the energy drink market has grown exponentially. Hundreds of different brands are now marketed, with caffeine content ranging from a modest 50 mg to an alarming 505 mg per can or bottle. Regulation of energy drinks, including content labeling and health warnings differs across countries, with some of the most lax regulatory requirements in the U. Read More

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January 2009
7 Reads

Coffee, caffeine-related genes, and Parkinson's disease: a case-control study.

Mov Disord 2008 Oct;23(14):2033-40

Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA.

An inverse association between coffee and Parkinson's disease (PD) has been reported. However, it remains uncertain why some but not all coffee drinkers are less susceptible to PD. We considered the possibility of a pharmacogenetic effect. Read More

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October 2008
3 Reads

Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray.

Anticancer Res 2008 Mar-Apr;28(2A):645-53

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Caffeine enhances the cytocidal effects of DNA-damaging agents. This study investigated genes involved in the synergistic effect of caffeine on osteosarcoma cells using gene-profiling analysis.

Materials And Methods: Sensitivity to cisplatin and the synergistic effect of caffeine were evaluated in five osteosarcoma cell lines with different p53 gene status. Read More

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June 2008
2 Reads

Caffeine-related genital skin pain.

Authors:
Atef Rizk Markos

J Low Genit Tract Dis 2008 Jan;12(1):38-9

Mid Staffordshire General Hospitals, NHS Trust, Stafford, United Kingdom.

Genital hyperesthesia is more recognized in women but may affect men. We report both a female and a male patient in whom caffeine intake was associated with genital hyperesthesia. Read More

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January 2008
1 Read

Pentoxifylline suppresses transduction by HIV-1-based vectors.

Intervirology 2007 15;50(5):377-86. Epub 2007 Oct 15.

Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Pentoxifylline, a caffeine-related compound, was shown to suppress human immunodeficiency virus type 1 (HIV-1) replication. This effect is thought to be mediated by inhibition of tumor necrosis factor-alpha (TNFalpha)-mediated long-terminal repeat (LTR)-driven expression. We now demonstrate that pentoxifylline efficiently inhibits transduction by HIV-1-based vectors. Read More

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November 2007
12 Reads

Determination of caffeine and caffeine-related metabolites in ephedra-containing standard reference materials using liquid chromatography with absorbance detection and tandem mass spectrometry.

J AOAC Int 2007 Jul-Aug;90(4):934-40

National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-8392, USA.

The concentrations of caffeine and caffeine-related compounds in 2 ephedra-containing reference materials have been determined by 3 independent methods with measurements performed by the National Institute of Standards and Technology (NIST) and a collaborating laboratory. Results from the 3 methods were used for value assignment of caffeine, theobromine, and theophylline in these Standard Reference Materials (SRMs). The methods used at NIST to determine the concentration levels of caffeine, theobromine, and theophylline in SRM 3243 Ephedra-Containing Solid Oral Dosage Form and SRM 3244 Ephedra-Containing Protein Powder used reversed-phase liquid chromatography with absorbance detection and tandem mass spectrometry. Read More

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November 2007
3 Reads

Awareness and use of caffeine by athletes competing at the 2005 Ironman Triathlon World Championships.

Int J Sport Nutr Exerc Metab 2006 Oct;16(5):545-58

School of Public Health and Heart Foundation Research Centre, Griffith University, Gold Coast, Queensland, Australia.

This study assessed the knowledge, prevalence, and quantity of caffeine use by athletes competing at the 2005 Ironman Triathlon World Championships. Caffeine-related questionnaires were self-administered to 140 (105 male and 35 female, 40.3 +/- 10. Read More

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October 2006
10 Reads

Placebo effects of caffeine on cycling performance.

Med Sci Sports Exerc 2006 Dec;38(12):2159-64

Canterbury Christ Church University, Canterbury, United Kingdom.

Purpose: The placebo effect-a change attributable only to an individual's belief in the efficacy of a treatment-might provide a worthwhile improvement in physical performance. Although sports scientists account for placebo effects by blinding subjects to treatments, little research has sought to quantify and explain the effect itself. The present study explored the placebo effect in laboratory cycling performance using quantitative and qualitative methods. Read More

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December 2006
14 Reads

Caffeine attenuates practice effects in word stem completion as measured by fMRI BOLD signal.

Hum Brain Mapp 2007 Jul;28(7):654-62

Department of Psychology, Cognition and Neuroimaging Laboratories, University of Arizona, Tucson, Arizona.

Caffeine ingestion results in increased brain cell metabolism (Nehlig et al. [1992] Brain Res Brain Res Rev 17:139-170) and decreased cerebral blood flow (Field et al. [2003] Radiology 227:129-135; Mulderink et al. Read More

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July 2007
1 Read

Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: an epidemiologic and co-twin control analysis.

Psychol Med 2006 Dec 8;36(12):1717-25. Epub 2006 Aug 8.

Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA 23298-0126, USA.

Background: Although caffeine is the most commonly used psychoactive substance and often produces symptoms of toxicity and dependence, little is known, especially in community samples, about the association between caffeine use, toxicity and dependence and risk for common psychiatric and substance use disorders.

Method: Assessments of lifetime maximal caffeine use and symptoms of caffeine toxicity and dependence were available on over 3600 adult twins ascertained from the population-based Virginia Twin Registry. Lifetime histories of major depression (MD), generalized anxiety disorder (GAD) and panic disorder, alcohol dependence, adult antisocial behavior and cannabis and cocaine abuse/dependence were obtained at personal interview. Read More

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December 2006
7 Reads

Differences in pharmacokinetic and electroencephalographic responses to caffeine in sleep-sensitive and non-sensitive subjects.

C R Biol 2006 Jul 6;329(7):512-9. Epub 2006 May 6.

Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics, Medicine Faculty of Sousse, 4002 Sousse, Tunisia.

The present study investigated pharmacokinetic and electroencephalographic responses to caffeine (140 mg) in two groups of healthy volunteers reporting, or not, caffeine-related sleep disturbances. Significant differences in caffeine consumption and smoking habits were observed between the two groups. Plasma samples were taken from each subject before (T0) and after caffeine intake at 0. Read More

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July 2006
1 Read

Analysis of diacetylmorphine, caffeine, and degradation products after volatilization of pharmaceutical heroin for inhalation.

J Anal Toxicol 2006 Jan-Feb;30(1):6-13

Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, PO Box 90440, 1006 BK Amsterdam, The Netherlands.

Pharmaceutical smokable heroin was developed for a clinical trial on medical co-prescription of heroin and methadone. This product, consisting of 75% w/w diacetylmorphine base and 25% w/w caffeine anhydrate, was intended for use via "chasing the dragon", that is, inhalation after volatilization. This procedure involves heating the powder mixture, which may lead to formation of degradation products that could subsequently be inhaled. Read More

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May 2006
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Effects of caffeine on olfactory and visual learning in the honey bee (Apis mellifera).

Pharmacol Biochem Behav 2005 Dec 10;82(4):664-72. Epub 2006 Jan 10.

Visual Sciences and Centre for the Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Canberra, ACT.

Although caffeine is known to improve alertness and arousal in humans and other mammals, its impacts on specific behaviours, including complex cognitive processes, remain controversial. We reasoned that the availability of an easily manipulable, but behaviourally complex invertebrate organism with a simpler nervous system would be beneficial to this field of research. We used a popular behavioural model, the honeybee, to evaluate the effects of caffeine on (1) the development of olfactory learning and (2) the performance in complex learning paradigms, including a 'delayed-match-to-sample' task and visual associative learning. Read More

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December 2005
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Caffeine and psychiatric medication interactions: a review.

J Okla State Med Assoc 2005 Aug;98(8):380-4

University of Oklahoma, USA.

Caffeine can cause or worsen psychiatric symptoms but also has the potential to interact with many psychiatric medications. This article provides a literature review regarding interactions between caffeine and psychiatric medications. Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme. Read More

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August 2005
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