9,062 results match your criteria CTS: Clinical and Translational Science [Journal]


The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia.

J Neuroinflammation 2018 Dec 15;15(1):343. Epub 2018 Dec 15.

Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Avd. Conocimiento 17, PTS Granada, 18016, Granada, Spain.

Background: Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular molecules in primary microglia that play a role in the transition of microglia to a ramified, neuroprotective phenotype. Read More

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December 2018

A novel software tool for semi-automatic quantification of thoracic aorta dilatation on baseline and follow-up computed tomography angiography.

Int J Cardiovasc Imaging 2018 Dec 14. Epub 2018 Dec 14.

LKEB, LUMC, Leiden, The Netherlands.

A dedicated software package that could semi-automatically assess differences in aortic maximal cross-sectional diameters from consecutive CT scans would most likely reduce the post-processing time and effort by the physicians. The aim of this study was to present and assess the quality of a new tool for the semi-automatic quantification of thoracic aorta dilation dimensions. Twenty-nine patients with two CTA scans of the thoracic aorta for which the official clinical report indicated an increase in aortic diameters were included in the study. Read More

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December 2018

Occurrence and diversity of cyanotoxins in Greek lakes.

Sci Rep 2018 Dec 14;8(1):17877. Epub 2018 Dec 14.

Institute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Grigoriou E' & Neapoleos 27, 15341, Athens, Greece.

Toxic cyanobacteria occur in Greek surface water bodies. However, studies on the occurrence of cyanotoxins (CTs) are often limited to mainly microcystins (MCs), with use of screening methods, such as ELISA, that are not conclusive of the chemical structure of the CT variants and can be subject to false positive results. A multi-lake survey in Greece (14 lakes) was conducted in water and biomass, targeted to a wide range of multi-class CTs including MCs, nodularin-R (NOD), cylindrospermopsin (CYN), anatoxin-a (ANA-a) and saxitoxins (STXs), using multi-class/variant LC-MS/MS analytical workflows, achieving sensitive detection, definitive identification and accurate quantitation. Read More

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December 2018

Posttreatment surveillance PET/CT for HPV-associated oropharyngeal cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Surveillance positron emission tomography-computed tomography (PET/CT) is commonly used for treatment assessment of radiation therapy in head and neck cancer. However, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC) patients represent a unique subpopulation, for which the utility of surveillance PET/CT has not been well studied.

Methods: In this retrospective chart review comprising 233 HPV+OPSCC patients, we evaluated surveillance PET/CT for diagnostic accuracy, downstream clinical impact, and survival. Read More

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December 2018

Analysis of condensed tannins in Populus spp. using reversed phase UPLC-PDA-(-)esi-MS following thiolytic depolymerisation.

Phytochem Anal 2018 Dec 11. Epub 2018 Dec 11.

Department of Entomology, University of Wisconsin-Madison, Madison, WI, USA.

Introduction: Condensed tannins (CTs) are proanthocyanidin heteropolymers that are widely distributed among plants. Their biochemical properties are determined by molecular structure (e.g. Read More

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December 2018

Development of a modified score system as prediction model for successful vaginal birth after cesarean delivery.

Clin Transl Sci 2018 Dec 10. Epub 2018 Dec 10.

The Second Department of Obstetrics, Cangzhou Central Hospital, NO.16, Xinhua Road, Yunhe District, Cangzhou, 061000, Hebei Province, China.

This study was designed to establish a modified prediction score system to improve the safety and success rate of vaginal birth after cesarean delivery (VBAC). We recruited 406 patients (between January 2012 and December 2016) and generated a modified score system in predicting the success rate of VBAC. All patients were required to sign informed consent forms. Read More

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December 2018

Tranilast treatment attenuates cerebral ischemia-reperfusion injury in rats through the inhibition of inflammatory responses mediated by NF- κB and PPARs.

Authors:
Yue Zhuo Jun Zhuo

Clin Transl Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Interventional Radiology, Affiliated Hospital of Jining Medical University, 89 Guhuai Rd, Jining, 272000, Shandong, China.

Ischemia-reperfusion injury (IRI) occurs when blood supply returns to tissue after interruption, which is associated with life-threatening inflammatory response. Tranilast is a widely used anti-allergic agent in the treatment against bronchial asthma and keloid. To study the function of tranilast, we used IRI rat model. Read More

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December 2018

Implementing the package of CDC and WHO recommended linkage services: Methods, outcomes, and costs of the Bukoba Tanzania Combination Prevention Evaluation: Peer-delivered, linkage case management program, 2014-2017.

PLoS One 2018 13;13(12):e0208919. Epub 2018 Dec 13.

National AIDS Control Program, MoHCDGEC, Dar es Salaam, Tanzania.

Although several studies have evaluated one or more linkage services to improve early enrollment in HIV care in Tanzania, none have evaluated the package of linkage services recommended by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). We describe the uptake of each component of the CDC/WHO recommended package of linkage services, and early enrollment in HIV care and antiretroviral therapy (ART) initiation among persons with HIV who participated in a peer-delivered, linkage case management (LCM) program implemented in Bukoba, Tanzania, October 2014 -May 2017. Of 4206 participants (88% newly HIV diagnosed), most received recommended services including counseling on the importance of early enrollment in care and ART (100%); escort by foot or car to an HIV care and treatment clinic (CTC) (83%); treatment navigation at a CTC (94%); telephone support and appointment reminders (77% among clients with cellphones); and counseling on HIV-status disclosure and partner/family testing (77%), and on barriers to care (69%). Read More

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December 2018

Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2018 Dec 13. Epub 2018 Dec 13.

Brigham and Women\'s Hospital, 1861, Medicine, Boston, Massachusetts, United States ;

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede the development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data from imaging studies.

Objectives: To assess quantitative measures of airway wall thickness (AWT) in populations characterized for interstitial lung abnormalities (ILA) and for IPF.

Methods: Chest computed tomography scans (CTs) and measures of AWT were available on 6073, 615, 1167, and 38 participants from COPDGene, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE), the Framingham Heart Study (FHS), and in IPF patients from the Brigham and Women's Hospital Herlihy Registry, respectively. Read More

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December 2018

Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy.

Front Neurosci 2018 27;12:796. Epub 2018 Nov 27.

Department of Medical Imaging, Jinling Hospital, Southern Medical University, Nanjing, China.

The objective was to study the modulation effects of levetiracetam on the fMRI activation/deactivation patterns associated with centrotemporal spikes (CTS) in Rolandic epilepsy. Forty patients with Rolandic epilepsy, including levetiracetam-medicated patients ( = 20) and drug-naive patients ( = 20), were studied. Single and sequential hemodynamic response functions-based EEG-fMRI analysis was performed to detect dynamic activation/deactivation associated with CTS. Read More

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November 2018

Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations.

Phys Med Biol 2018 Nov 22. Epub 2018 Nov 22.

Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, UNITED STATES.

Purpose: To develop an online plan adaptation algorithm for intensity modulated proton therapy (IMPT) based on fast Monte Carlo dose calculation and cone beam CT (CBCT) imaging. Methods: A cohort of 10 head and neck cancer patients with an average of 6 CBCT scans were studied. To adapt the treatment plan to the new patient geometry, contours were propagated to the CBCTs with a vector field (VF) calculated with deformable image registration between the CT and the CBCTs. Read More

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November 2018

CT-based dose recalculations in head and neck cancer radiotherapy: comparison of daily dose recalculations to less time-consuming approaches.

Strahlenther Onkol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Straße 22, 81675, Munich, Germany.

Background: The goal of this study was to investigate if daily dose recalculations are necessary or if less time-consuming approaches can be used to identify dose differences to the planned dose in patients with head and neck cancers (H&N).

Methods: For 12 H&N patients treated with helical tomotherapy, daily dose calculations were performed retrospectively. Four different summation doses (SuDo) were calculated: DayDo (daily dose calculation), MVCTx2, MVCTx5, and MVCTx10 (dose calculations every second, fifth, and tenth fraction). Read More

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December 2018

Bilateral Cerebrovascular Stroke as an Initial Presenting Symptom of Moyamoya Disease.

Case Rep Crit Care 2018 13;2018:2591494. Epub 2018 Nov 13.

Lincoln Medical and Mental Health Center, 234 E 149Th St., Bronx, NY 10451, USA.

Moyamoya disease is a rare condition affecting the circle of Willis and its branching arteries. While the pathogenesis is unclear, it causes progressive occlusion of multiple cerebral vessels leading to severe strokes. We report a case of a 47-year-old Hispanic woman with HTN presented with altered mental status and bilateral upper and lower extremity weakness with dystonic-like upper extremity movement. Read More

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November 2018

The Meningococcal Cysteine Transport System Plays a Crucial Role in Survival in Human Brain Microvascular Endothelial Cells.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

RIKEN Structural Biology Laboratory, Yokohama, Japan.

While typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive to meningococci, needs to exploit nutrients from host environments. In the present study, the utilization of cysteine by the meningococcal cysteine transport system (CTS) was analyzed for the pathogenesis of meningococcal infections. Read More

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December 2018
4 Reads

Cold effect in median nerve conductions in clinical carpal tunnel syndrome with normal nerve conduction studies.

J Clin Neurosci 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Kirikkale University, Faculty of Medicine, Yenişehir Mahallesi, Ankara Road 7.Km., Kırıkkale Üniversitesi Kampüsü, 71450 Yahşihan, Kırıkkale, Turkey. Electronic address:

Clinical diagnosis of carpal tunnel syndrome (CTS) is confirmed by nerve conduction studies (NCS). In some cases, NCS may be normal. We aimed to demonstrate changes of distal motor latency (DML) and nerve conduction velocity (NCV) pathology of demyelination in entrapment neuropathy with cold application in case of clinical CTS with normal NCS. Read More

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December 2018
1 Read

Hind- and Midfoot Bone Morphology Varies with Foot Type and Sex.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

RR&D Center for Limb Loss and MoBility, VA Puget Sound, Seattle, WA.

Foot type has been associated with pain, injury, and altered gait mechanics. Morphological variations in foot bones due to foot type variation may impact surgical and therapeutic treatments. The purpose of this study was to utilize principal component analysis (PCA) to determine how morphology of the hind- and midfoot bones differs among foot types and sex. Read More

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December 2018
1 Read

Simultaneous Co-segmentation of Tumors in PET-CT Images Using Deep Fully Convolutional Networks.

Med Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Electrical and Computer Engineering, the University of Iowa.

Purpose: To investigate the use and efficiency of 3-D deep learning, fully convolutional networks (DFCN) for simultaneous tumor co-segmentation on dual-modality non-small cell lung cancer (NSCLC) PET-CT images.

Methods: We used DFCN co-segmentation for NSCLC tumors in PET-CT images, considering both the CT and PET information. The proposed DFCN-based co-segmentation method consists of two coupled 3D-UNets with an encoder-decoder architecture, which can communicate with the other in order to share complementary information between PET and CT. Read More

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December 2018
1 Read

Relative bioavailability of orally dispersible/disintegrating tablet formulations of levo- and racemic praziquantel: Two Phase I studies.

Clin Transl Sci 2018 Dec 7. Epub 2018 Dec 7.

Quantitative Pharmacology, Merck KGaA, Frankfurter Strasse 250, 64293, Darmstadt, Germany.

Orally dispersible tablet (ODT) formulations of L- and racemic praziquantel (PZQ) are being developed to treat schistosomiasis in preschool-aged children. Two cross-over studies (N=32 and 36 resp.) assessed the relative bioavailability of these ODTs versus Cysticide in adults. Read More

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December 2018
2 Reads

Exclusion of Older Adults from Ongoing Clinical Trials on Low Back Pain: A Review of the WHO Trial Registry Database.

J Am Geriatr Soc 2018 Dec 8. Epub 2018 Dec 8.

School of Rehabilitation Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Background/objectives: The burden of low back pain (LBP) is high, especially for older adults who experience a higher number of years living with a disability. However, this population is not being well represented in clinical trials (CTs). This study analyzed the International Clinical Trial Registry Platform (ICTRP) database from the World Health Organization to verify the future trend in the participation of older adults in registered CTs on LBP. Read More

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December 2018
1 Read

Nutritional potentialities of some tree leaves based on polyphenols and rumen gas production.

Vet World 2018 Nov 23;11(10):1479-1485. Epub 2018 Oct 23.

Department of Animal Nutrition, Veterinary College, Bengaluru, Karnataka, India.

Aim: The study was conducted to evaluate eight tree leaves based on polyphenolic content and rumen incubation and gas production technique (RIVIGPT) for their nutritive potentiality.

Materials And Methods: Eight selected tree leaves, namely , , spp., , , , , and , were selected for proximate composition, forage fiber fractions, total phenolics (TPs), non-tannin phenols (NTPs), total tannins (TTs), condensed tannins (CTs), and hydrolysable tannins (HTs); RIVIGP with and without polyethylene glycol (PEG); and dry matter digestibility (IVDMD) (modified two stage) analysis was conducted. Read More

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November 2018
1 Read

Preparation of nanochitin-contained magnetic chitosan microfibers via continuous injection gelation method for removal of Ni(II) ion from aqueous solution.

Int J Biol Macromol 2018 Dec 6. Epub 2018 Dec 6.

College of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China; Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Shanghai Genius Advanced Material Co., Ltd, Shanghai 201109, China. Electronic address:

In this study, nanochitin-contained magnetic chitosan (FPCC) microfibers were prepared successfully via continuous injection gelation method and employed to remove Ni(II) ion from aqueous solution. Firstly, FeO-nanoparticles were encapsulated into ε-caprolactam (CL) monomer solution in the presence of polystyrene (PSE), followed by CL anionic ring-opening polymerization and PSE removal, and obtained magnetic polyamide 6 (PA 6) microparticles (FP). After that, the economical FPCC microfibers can be prepared by adding FP microparticles and nanochitin (n-CT) into poly(vinyl alcohol)/chitosan hybrids (PVA/CTS). Read More

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December 2018

Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis.

Prog Lipid Res 2018 Dec 4;73:65-91. Epub 2018 Dec 4.

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China. Electronic address:

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is removed by the reverse cholesterol transport (RCT) pathway, representing a major antiatherogenic mechanism. In addition to the RCT, other pathways are required for maintaining the whole-body cholesterol homeostasis. Read More

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December 2018

Carpal tunnel syndrome due to hibernoma of the wrist: Case report.

Hand Surg Rehabil 2018 Dec 5. Epub 2018 Dec 5.

Service de traumatologie orthopédie I, Hôpital militaire d'instruction Mohamed V, Hay Ryad (avenue des FAR), 10000 Rabat, Morocco.

Carpal tunnel syndrome (CTS) is the most frequent among entrapment neuropathies. The usual etiology is idiopathic, but can be caused by space-occupying lesions, a relatively rare condition. This condition becomes exceptional when the space-occupying lesion corresponds to a rare tumor whose location is atypical. Read More

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December 2018

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

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December 2018
5 Reads

An RK/ST C-terminal Motif is Required for Targeting of OEP7.2 and a Subset of Other Arabidopsis Tail-Anchored Proteins to the Plastid Outer Envelope Membrane.

Plant Cell Physiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Tail-anchored (TA) proteins are a unique class of integral membrane proteins that possess a single C-terminal transmembrane domain and target post-translationally to the specific organelles at which they function. While significant advances have been made in recent years in elucidating the mechanisms and molecular targeting signals involved in the proper sorting of TA proteins, particularly to the endoplasmic reticulum and mitochondria, relatively little is known about the targeting of TA proteins to the plastid outer envelope. Here we show that several known or predicted plastid TA outer envelope proteins (OEPs) in Arabidopsis possess a C-terminal RK/ST sequence motif that serves as a conserved element of their plastid targeting signal. Read More

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December 2018
3 Reads

Cryptotanshinone inhibits RANKL-induced osteoclastogenesis by regulating ERK and NF-κB signaling pathways.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Orthopedics, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Osteoporosis (OS) is one of the most common healthy problems characterized by low bone mass. Osteoclast, the primary bone-resorbing cell, is responsible for destructive bone diseases including osteoporosis (OS). Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza bunge, has been shown to prevent the destruction of cartilage and the thickening of subchondral bone in mice osteoarthritis models. Read More

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December 2018
1 Read

Clinical Care Redesign to Improve Value in Carpal Tunnel Syndrome: A Before-and-After Implementation Study.

J Hand Surg Am 2018 Nov 28. Epub 2018 Nov 28.

Department of Orthopedics, VOICES Health Policy Research Center, Stanford University, Redwood City, CA; One Medical, San Francisco, CA.

Purpose: Carpal tunnel surgery is one of the most common procedures completed on the upper limb in the United States. There is currently no evidence-based high-value clinical care pathway to inform the management of carpal tunnel syndrome (CTS). We created an evidence-based care pathway and implemented a quality improvement initiative to evaluate its effect on patient time, quality, and cost in a tertiary care ambulatory surgery center. Read More

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November 2018
1 Read

Cost-Effectiveness Evaluation of Manual Physical Therapy Versus Surgery for Carpal Tunnel Syndrome: Evidence From a Randomized Clinical Trial.

J Orthop Sports Phys Ther 2018 Nov 30:1-27. Epub 2018 Nov 30.

Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Spain.

Study Design: A randomized clinical trial.

Background: Carpal tunnel syndrome (CTS) results in substantial costs for the society and can be treated by either nonsurgical or surgical approaches.

Objective: To evaluate cost-effectiveness differences of manual physical therapy versus surgery in women with CTS. Read More

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November 2018
1 Read

Considerations for Implementing Precision Therapeutics for Children.

Clin Transl Sci 2018 Dec 5. Epub 2018 Dec 5.

Children's Mercy Hospital, Kansas City, MO.

Improving the utilization of pharmacologic agents in the pediatric population yields significant, perhaps life-long, benefits. Genetic factors related to the disposition of a medication or an alteration at the target receptor site contribute to the observed variability of exposure and response between individuals. An additional source of this variability specific to the pediatric population is ontogeny, where age-specific changes during development may require dose adjustments to obtain the same levels of drug exposure and response. Read More

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December 2018

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.

Parasit Vectors 2018 Dec 4;11(1):622. Epub 2018 Dec 4.

Department of Parasitology, Faculty of Science, University of Granada, Granada, Spain.

Background: Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. In this study, we examine the potential functions of two proteins of Leishmania major, PHB1 and PHB2, as well as how they might help protect the protozoan against oxidative stress. Read More

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December 2018
1 Read

Menopausal hormone therapy and the incidence of carpal tunnel syndrome in postmenopausal women: Findings from the Women's Health Initiative.

PLoS One 2018 4;13(12):e0207509. Epub 2018 Dec 4.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States of America.

Importance: Carpal tunnel syndrome (CTS) is a common and debilitating condition that commonly affects postmenopausal women.

Objective: To determine the effect of menopausal hormone therapy (HT) in healthy postmenopausal women on CTS risk.

Design: We conducted a secondary analysis of the Women's Health Initiative's (WHI) HT trials linked to Medicare claims data. Read More

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December 2018
2 Reads

Arthropathy-like findings and a carpal tunnel syndrome as the presenting features of Scheie syndrome: Three cases from the same family.

Turk J Pediatr 2018 ;60(3):344-347

Pediatric Rheumatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Gökay S, Kardaş F, Kendirci M, Sözeri B. Arthropathy-like findings and a carpal tunnel syndrome as the presenting features of Scheie syndrome: Three cases from the same family. Turk J Pediatr 2018; 60: 344-347. Read More

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January 2018
4 Reads

The 2015 Amtrak Philadelphia Train Derailment: After-Action Review of the Emergency Radiology Response at Temple University Health System.

J Am Coll Radiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania.

Purpose: The aim of this article is to assess a large tertiary care medical center's emergency radiology response after the 2015 Amtrak Philadelphia train derailment.

Methods And Materials: A total of 55 patients with 308 total CTs and radiographs ordered within 12 hours of arrival to Temple University Health System (combining Temple University Hospital and Episcopal Hospital) emergency departments on May 12 to 13, 2015, were included in this study. A retrospective PACS and electronic medical record chart review of emergency department imaging turnaround times (TAT) during this event was completed and compared with emergency department radiology operations for the same 12-hour period throughout the preceding year. Read More

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November 2018
1 Read

The Association Between Concomitant Ulnar Nerve Compression at the Elbow and Carpal Tunnel Syndrome.

Hand (N Y) 2018 Nov 30:1558944718813669. Epub 2018 Nov 30.

1 NYU Langone Orthopedic Hospital, New York City, USA.

Background: Many patients treated for ulnar nerve compression at the elbow (UNE) are concomitantly treated for carpal tunnel syndrome (CTS). We sought to investigate the association between the conditions.

Methods: The Statewide Planning and Research Cooperative System (SPARCS) database was used to determine the number of patients with UNE concomitantly treated for CTS in New York State from 2003 to 2014. Read More

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November 2018
1 Read

Dosimetric Impact of MRI distortions - A study on Head and Neck Cancers.

Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Sciences, Umeå University, Sweden.

Purpose: To evaluate the effect of magnetic resonance imaging (MRI) geometric distortions on head and neck radiotherapy treatment planning (RTP) in for an MRI-only RTP. We also assessed the potential benefits of patient-specific shimming to reduce the magnitude of MR distortions for a 3 T scanner.

Materials And Methods: Using an in-house Matlab algorithm, shimming within entire imaging volumes and user-defined region of interest (ROI) were simulated. Read More

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November 2018

Properties of the anisotropy of dose contributions: A planning study on prostate cases.

Med Phys 2018 Nov 29. Epub 2018 Nov 29.

University of Würzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Purpose: To characterize the static properties of the anisotropy of dose contributions for different treatment techniques on real patient data (prostate cases). From this, we aim to define a class of treatment techniques with invariant anisotropy distribution carrying information of target coverage and organ-at-risk sparing. The anisotropy presumably is a helpful quantity for plan adaptation problems. Read More

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November 2018
2 Reads

Missing Cases of Herpes simplex virus (HSV) Infection of the Central Nervous System Applying Reller Criteria for HSV PCR testing: A Multicenter Study.

J Clin Microbiol 2018 Nov 28. Epub 2018 Nov 28.

Microbiology Service, Hospital Clínico Universitario, Instituto de Investigación INCLIVA, Valencia, Spain

Previous studies suggested that Herpes simplex virus (HSV) PCR testing can be safely deferred in patients with normal cerebrospinal fluid (CSF) white blood cell (WBC) counts and protein levels as long as they are older than two years of age and are not immunocompromised, the so-called Reller criteria. In this multicenter study, we retrospectively assessed the validity of this screening criteria in our setting. A total of 4,404 CSF specimens submitted to the respective microbiology laboratories at the participating hospitals between 2012 and 2018 for HSV PCR testing were included. Read More

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November 2018
1 Read

Predicting outcomes in rheumatoid arthritis related interstitial lung disease.

Eur Respir J 2018 Nov 28. Epub 2018 Nov 28.

Interstitial Lung Disease Unit, Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

To compare radiology-based prediction models in rheumatoid arthritis-related interstitial lung disease (RA-ILD) to identify patients with a progressive fibrosis phenotype. RAILD patients had CTs scored visually and by CALIPER and forced vital capacity (FVC) measurements. Outcomes were evaluated using three techniques: 1. Read More

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November 2018
1 Read
7.636 Impact Factor

Current Data on Effects of Long-Term Missions on the International Space Station on Skin Physiological Parameters.

Skin Pharmacol Physiol 2019 28;32(1):43-51. Epub 2018 Nov 28.

DermaTronnier, Institute for Experimental Dermatology, Witten/Herdecke University, Witten, Germany.

Background: Skin reaction to spaceflight has not really been studied yet, although the skin has a very important barrier function to protect the body and can contribute to a more general understanding of physiology. It is proposed here to make a more thorough investigation of the skin during long-term spaceflight, using noninvasive techniques.

Aims: The aim of the present Skin-B study is to investigate the kinetics and range of possible skin modifications during long-duration spaceflights and their recovery. Read More

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November 2018

Hyaluronic Acid-Functionalized Gadolinium Doped Iron Oxide Nanoparticles for Atherosclerosis-Targeted Mr Imaging.

J Biomed Nanotechnol 2019 Jan;15(1):127-137

Magnetic resonance imaging (MRI) contrast agents (CTs) with both positive () and negative (₂) contrast abilities have attracted considerable interests due to their complementary diagnostic information for more precise diagnosis. In this study, gadolinium-doped oxide nanoparticles functionalized by hyaluronic acid (HA-GdIO NPs) were synthesized for atherosclerosis-targeting -₂ dual-model MR imaging. The results showed that the HA-GdIO NPs exhibited high magnetic susceptibility and good biocompatibility. Read More

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January 2019
2 Reads

miR-146a regulates the crosstalk between intestinal epithelial cells, microbial components and inflammatory stimuli.

Sci Rep 2018 Nov 26;8(1):17350. Epub 2018 Nov 26.

Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Granada, Spain.

Regulation of miR-146a abundance and its role in intestinal inflammation and particularly in intestinal epithelial cells (IECs) has been poorly studied. Here we study the relationship between bacterial antigens and inflammatory stimuli, and miR-146a expression using IEC lines and models of colitis (trinitrobenzenesulfonic acid (TNBS), dextran sulfate sodium (DSS) and the CD4 + CD62L + T cell transfer model). Specific bacterial antigens and cytokines (LPS, flagelin and IL-1β/TNF) stimulate miR-146a expression, while peptidoglycan, muramyldipeptide and CpG DNA have no effect. Read More

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November 2018
5 Reads

Ultrasound assisted preparation, characterization and adsorption study of ternary chitosan-ZnO-TiO nanocomposite: Advantage over conventional method.

Ultrason Sonochem 2018 Nov 7. Epub 2018 Nov 7.

Department of Chemical Engineering, National Institute of Technology, Warangal 506004, Telangna State, India.

In the present work, the synthesis of ternary chitosan/zinc oxide/titanium dioxide (CTS-ZnO-TiO) nanocomposite was carried out with the use of mechanical stirring (conventional) and ultrasound assisted method. The characterization of prepared CTS-ZnO-TiO adsorbent was carried out using XRD, TEM, FTIR and the results of these analysis methods proved the successful preparation of ternary nanocomposite. Crystal violet (CV) dye was used as a pollutant to observe the adsorption ability of the prepared nanocomposite and the nanocomposite prepared by ultrasonic-assisted method proved to be a better adsorbent. Read More

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November 2018

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial.

J Clin Med 2018 Nov 24;7(12). Epub 2018 Nov 24.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, "Virgen de las Nieves" University Hospital, 18014 Granada, Spain.

This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise ( = 26) or usual care ( = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40⁻75% of the individual's heart rate reserve. Read More

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November 2018
21 Reads

Men's perspectives on the impact of female-directed cash transfers on gender relations: Findings from the HPTN 068 qualitative study.

PLoS One 2018 26;13(11):e0207654. Epub 2018 Nov 26.

Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: HIV is an inherently gendered disease in eastern and southern Africa, not only because more women than men are infected, but also because socially constructed gender norms work to increase women's HIV-infection risk. The provision of cash transfers to young women alone in such a context adds another dimension to already existing complex social relations where patriarchal values are entrenched, gender inequality is the norm, and violence against women and girls is pervasive. It raises concerns about complicating young women's relationships with their male partners or possibly even setting them up for more violence. Read More

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November 2018
3.230 Impact Factor

Unveiling the Genetic Architecture of Human Disease for Precision Medicine.

Clin Transl Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, Arizona, USA.

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November 2018
5 Reads

Dosimetric evaluation of an atlas-based synthetic CT generation approach for MR-only radiotherapy of pelvis anatomy.

J Appl Clin Med Phys 2018 Nov 26. Epub 2018 Nov 26.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To investigate the potential of an atlas-based approach in generation of synthetic CT for pelvis anatomy.

Methods: Twenty-three matched pairs of computed tomography (CT) and magnetic resonance imaging (MRI) scans were selected from a pool of prostate cancer patients. All MR scans were preprocessed to reduce scanner- and patient-induced intensity inhomogeneities and to standardize their intensity histograms. Read More

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November 2018
2 Reads

Comparative study of nomophobia among Spanish and Portuguese nursing students.

Nurse Educ Pract 2018 Nov 17;34:79-84. Epub 2018 Nov 17.

Department of Nursing, Physiotherapy and Medicine, Research Group for Health Sciences CTS-451, Faculty of Health Sciences, University of Almeria, Sacramento S/N, en La Cañada de San Urbano, CP: 04120, Spain. Electronic address:

Nomophobia is the fear of leaving the house without a mobile and being out of mobile phone contact and affects different areas of a person's life, especially in terms of social, work and academic relationships due to a dependence on the use of smartphones. Discovering the prevalence of nomophobia among nursing students is very important, as the misuse of smartphones in clinical practice may cause distractions, affecting the quality of care and putting patient safety at risk. Furthermore, it can lead to poorer academic performance during class. Read More

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November 2018
5 Reads

Revision surgery in carpal tunnel syndrome: a retrospective study comparing the Canaletto® device alone versus a combination of Canaletto and Dynavisc gel.

Hand Surg Rehabil 2018 Nov 21. Epub 2018 Nov 21.

Department of hand surgery, SOS main, CCOM, university hospital of Strasbourg, FMTS, University of Strasbourg, Icube CNRS 7357, 10, avenue Baumann, 67400 Illkirch, France. Electronic address:

The aim of our study was to demonstrate the benefits of combining the Canaletto® implant with carboxymethylcellulose/polyethylene oxide gel in the surgical treatment of carpal tunnel syndrome (CTS) recurrences. Our case series included 39 patients (40 hands, one bilateral case) who underwent revision surgery for recurrent CTS (28 cases) or resistant CTS (12 cases). The mean age of the patients was 56 years. Read More

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November 2018
12 Reads

A fast, linear Boltzmann transport equation solver for computed tomography dose calculation (Acuros CTD).

Med Phys 2018 Nov 24. Epub 2018 Nov 24.

Department of Biomedical Engineering, Marquette University, Milwaukee, WI, 53201, USA.

Purpose: To improve dose reporting of CT scans, patient-specific organ doses are highly desired. However, estimating the dose distribution in a fast and accurate manner remains challenging, despite advances in Monte Carlo methods. In this work, we present an alternative method that deterministically solves the linear Boltzmann transport equation (LBTE), which governs the behavior of x-ray photon transport through an object. Read More

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November 2018