1,051 results match your criteria COPD: Journal of Chronic Obstructive Pulmonary Disease [Journal]


Prevalence of Comorbid Chronic Obstructive Pulmonary Disease in Individuals Suffering from Schizophrenia and Bipolar Disorder: A Systematic Review.

COPD 2019 Feb 4:1-9. Epub 2019 Feb 4.

a Department of Pulmonology , School of Health Science, University of Patras , Patras , Greece.

The disease burden associated with schizophrenia and bipolar disorder is substantial, with affected individuals having a shorter life expectancy and a high risk of severe physical comorbid conditions. These individuals are more likely to smoke and have a longer smoking history compared to the general population. Furthermore, use of antipsychotic drugs has also been linked to active smoking. Read More

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http://dx.doi.org/10.1080/15412555.2019.1572730DOI Listing
February 2019
2 Reads

Palliative Care Provision for Patients with Advanced Chronic Obstructive Pulmonary Disease: A Systematic Integrative Literature Review.

COPD 2019 Feb 4:1-12. Epub 2019 Feb 4.

c International Observatory on End of Life Care, Faculty of Health and Medicine, Lancaster University, Lancaster , UK.

Although chronic obstructive pulmonary disease (COPD) is recognized as being a life-limiting condition with palliative care needs, palliative care provision is seldom implemented. The disease unpredictability, the misconceptions about palliative care being only for people with cancer, and only relevant in the last days of life, prevent a timely integrated care plan. This systematic review aimed to explore how palliative care is provided in advanced COPD and to identify elements defining integrated palliative care. Read More

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http://dx.doi.org/10.1080/15412555.2019.1566893DOI Listing
February 2019
1 Read

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

COPD 2019 Feb 4:1-9. Epub 2019 Feb 4.

c Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , USA.

Mucus hydration is important in mucus clearance and lung health. This study sought to test the relative utility of spontaneous sputum (SS) versus the reasonably noninvasive induced sputum (IS) samples for measurement of mucus hydration. SS and IS samples were collected over a 2-day study interval. Read More

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http://dx.doi.org/10.1080/15412555.2019.1566892DOI Listing
February 2019
1 Read

The role of physical activity in the context of pulmonary rehabilitation.

COPD 2019 Feb 4:1-8. Epub 2019 Feb 4.

a Department of Rehabilitation Sciences , KU Leuven - University of Leuven , Leuven , Belgium.

Pulmonary rehabilitation is an important treatment for patients with chronic obstructive pulmonary disease (COPD). Although this intervention leads to large and clinically meaningful improvements in exercise capacity and quality of life, the effect of pulmonary rehabilitation on physical activity is controversial. Physical activity is lower in patients with COPD as compared to healthy age-matched controls and it is related to important health outcomes (e. Read More

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http://dx.doi.org/10.1080/15412555.2018.1563060DOI Listing
February 2019
1 Read

Adenosine Metabolism in COPD: A Study on Adenosine Levels, 5'-Nucleotidase, Adenosine Deaminase and Its Isoenzymes Activity in Serum, Lymphocytes and Erythrocytes.

COPD 2019 Jan 19:1-13. Epub 2019 Jan 19.

a Department of Biochemistry , Vallabhbhai Patel Chest Institute, University of Delhi , Delhi , India.

Adenosine is a signaling molecule which is produced in high concentrations during airway inflammation. Airway inflammation is a characteristic feature of COPD. Therefore, the current study was designed to evaluate the changes in adenosine metabolism in COPD and correlate these changes with severity of the disease. Read More

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http://dx.doi.org/10.1080/15412555.2018.1537365DOI Listing
January 2019
1 Read

Spirometric instability - another hurdle in achieving real-world COPD diagnostic criteria?

COPD 2018 Dec 30:1-2. Epub 2018 Dec 30.

b Department of Clinical Medical Sciences, Faculty of Medical Sciences , The University of the West Indies, St Augustine Campus , Trinidad and Tobago.

Globally, mortality, morbidity and the economic burden of chronic obstructive pulmonary disease (COPD) are on the rise. In addition, its diagnosis continues to pose challenges to the physicians, which is compounded further by its new feature "spirometric instability." Based on the findings from the two recent observational studies, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommended repeat spirometry for the individuals with a fixed ratio between 0. Read More

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http://dx.doi.org/10.1080/15412555.2018.1534947DOI Listing
December 2018
1 Read

The Role of Cardiopulmonary Exercise Testing (CPET) in Pulmonary Rehabilitation (PR) of Chronic Obstructive Pulmonary Disease (COPD) Patients.

COPD 2018 Dec 30:1-11. Epub 2018 Dec 30.

b Respiratory Research Center, Royal University Hospital , University of Saskatchewan , Saskatoon , Canada.

Chronic obstructive pulmonary disease (COPD) is a common multisystem inflammatory disease with ramifications involving essentially all organ systems. Pulmonary rehabilitation is a comprehensive program designed to prevent and mitigate these disparate systemic effects and improve patient quality of life, functional status, and social functioning. Although initial patient assessment is a prominent component of any pulmonary rehabilitation (PR) program, cardiopulmonary exercise testing (CPET) is not regularly performed as a screening physiologic test prior to PR in COPD patients. Read More

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http://dx.doi.org/10.1080/15412555.2018.1550476DOI Listing
December 2018
1 Read

Obesity in COPD: Comorbidities with Practical Consequences?

COPD 2018 Dec 4:1-8. Epub 2018 Dec 4.

a Department of Pulmonary Disease , Rijnstate hospital , Arnhem , Netherlands.

COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPD) and non-obese COPD (COPD) individuals was studied. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1509951DOI Listing
December 2018
11 Reads

Minimal Important and Detectable Differences of Respiratory Measures in Outpatients with AECOPD.

COPD 2018 Dec 4:1-10. Epub 2018 Dec 4.

b Lab 3R - Respiratory Research and Rehabilitation Laboratory, School of Health Sciences , University of Aveiro , Aveiro , Portugal.

Interpreting clinical changes during acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is challenging due to the absence of established minimal detectable (MDD) and important (MID) differences for most respiratory measures. This study established MDD and MID for respiratory measures in outpatients with AECOPD following pharmacological treatment. COPD assessment test (CAT), modified Borg scale (MBS), modified British Medical Research Council (mMRC) questionnaire, peripheral oxygen saturation (SpO), computerised respiratory sounds and forced expiratory volume in one second (FEV) were collected within 24-48 hour of an AECOPD and after 45 days of pharmacological treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1537366DOI Listing
December 2018
9 Reads

Pattern of Cardiovascular Comorbidity in COPD in a Country with Low-smoking Prevalence: Results from Two-population-based Cohorts from Sweden.

COPD 2018 Nov 26:1-10. Epub 2018 Nov 26.

a Krefting Research Centre , Institute of Medicine, University of Gothenburg , Gothenburg , Sweden.

Cardiovascular diseases are the most common comorbidities in COPD, due to common risk factors such as smoking. The prevalence of current smokers in Sweden has decreased over four decades to around 10%. The aim of the present study was to investigate the prevalence, distribution and associations of cardiovascular comorbidities in COPD by disease severity in two large areas of Sweden, both with low-smoking prevalence. Read More

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http://dx.doi.org/10.1080/15412555.2018.1535580DOI Listing
November 2018
12 Reads

Monitoring Antioxidant Enzyme Activity during Exacerbations of Chronic Obstructive Pulmonary Disease.

COPD 2018 Nov 26:1-7. Epub 2018 Nov 26.

a Department of Pathophysiology , National Koranyi Institute for TB and Pulmonology , Budapest , Hungary.

Superoxide dismutases (SODs) and catalase (CAT) have been implicated as major antioxidant enzymes of the human lungs. In this study, we investigated whether activities of these enzymes are altered in the airways of patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). SOD and CAT activities were measured in the sputum, exhaled breath condensate, and serum of 36 COPD patients experiencing a severe exacerbation. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1535581DOI Listing
November 2018
8 Reads

COPD Assessment Test (CAT) is a Valid and Simple Tool to Measure the Impact of Bronchiectasis on Affected Patients.

COPD 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Postgraduate Program in Rehabilitation Sciences , Universidade Nove de Julho - UNINOVE , São Paulo , Brazil.

The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremental shuttle walk test (ISWT), Saint George`s Respiratory Questionnaire (SGRQ), and received pedometer. Read More

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http://dx.doi.org/10.1080/15412555.2018.1540034DOI Listing
November 2018
8 Reads

Role of Stem Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema.

COPD 2018 Oct 23;15(5):536-556. Epub 2018 Nov 23.

a Dipartimento di Scienze Biomediche, Unità Operativa Complessa di Pneumologia , Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di Messina , Messina , Italy.

There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we strongly believe that more human translational studies are essential, otherwise, the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this incurable disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1536116DOI Listing
October 2018
10 Reads

The Impact of Loneliness on Outcomes of Pulmonary Rehabilitation in Patients with COPD.

COPD 2018 Nov 7:1-8. Epub 2018 Nov 7.

a Health Psychology , University of Leuven , Leuven , Belgium.

Psychological factors such as negative affect have been demonstrated to impact course and treatment of chronic obstructive pulmonary disease (COPD). However, little is known about the respective impact of social factors. In several other chronic diseases, loneliness has been shown to predict morbidity, but little is known about its impact on COPD. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1471128DOI Listing
November 2018
17 Reads

Health Status in Patients with COPD According to GOLD 2017 Classification: Use of the COMCOLD Score in Routine Clinical Practice.

COPD 2018 Nov 6:1-8. Epub 2018 Nov 6.

a Hospital Universitario Nuestra Señora de la Candelaria , Santa Cruz de Tenerife , Spain.

The COMCOLD score was developed to quantify the impact of comorbidities on health status in patients with chronic obstructive pulmonary disease (COPD). The objective of this study is to evaluate the association between health status in outpatients with COPD according to COMCOLD score and the GOLD 2017 groups according to symptoms (B and D vs. A and C) and exacerbations (C and D vs. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1531388DOI Listing
November 2018
15 Reads

Combining the Pulmonary Rehabilitation Decisional Score with the Bode Index and Clinical Opinion in Assigning Priority for Pulmonary Rehabilitation.

COPD 2018 06 6;15(3):238-244. Epub 2018 Nov 6.

a Istituti Clinici Scientifici Maugeri IRCCS, Scientific Direction of the Institute of Lumezzane , Brescia , Italy.

Combining objective tools with clinical decision (CD) may help clinicians identify the priority for pulmonary rehabilitation (PR) in patients with COPD. We aimed to assess the specificity, sensitivity and efficiency of a new tool, the Pulmonary Rehabilitation Decisional Score (PRDS), and its correlation with the BODE index (BI) and CD in assigning PR priority. We retrospectively compared the three methods (CD vs. Read More

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http://dx.doi.org/10.1080/15412555.2018.1531389DOI Listing
June 2018
1 Read

Current Status of Pulmonary Rehabilitation: Introductory Remarks on Pulmonary Rehabilitation, the Importance and the Practice.

COPD 2018 06 2;15(3):215-218. Epub 2018 Nov 2.

b School of Medical and Pharmaceutical Sciences , University of Genoa , Genoa , Italy.

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http://dx.doi.org/10.1080/15412555.2018.1478398DOI Listing
June 2018
2 Reads

Geographical Distribution of COPD Prevalence in the Americas.

COPD 2018 Oct 30:1-9. Epub 2018 Oct 30.

f Pneumology Department , Hospital Universitari Vall d'Hebron , Barcelona , Spain.

Surveys estimating chronic obstructive pulmonary disease (COPD) prevalence are unevenly distributed in the Americas, which make it difficult to estimate accurately its geographical distribution. The geographic information system inverse distance weighted (IDW) interpolation technique has proved to be an effective tool in spatial distribution estimation of epidemiological variables, even when real data are few or widely spread. We aimed to represent cartographically the COPD prevalence in the Americas by means of a blue to red scale representation of the prevalence data, where different values are represented as different colours, and a population density filtered IDW interpolation mapping, where areas with a population density <0. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1481936DOI Listing
October 2018
12 Reads

Postoperative outcomes of frequent exacerbator patients with Chronic Obstructive Pulmonary Disease after resection of Non-Small Cells Lung Cancer.

COPD 2018 Oct 30:1-8. Epub 2018 Oct 30.

c Departement of Thoracic Surgery, Paris Center University Hospital , Paris Descartes University , Paris , France.

Chronic obstructive pulmonary disease (COPD) is a risk factor of post-operative complications after lung cancer resection. The influence of the "frequent exacerbator (FE)" phenotype (at least three exacerbations per year) is unknown. Postoperative outcomes of frequent exacerbators (POFE) was a prospective observational study of patients with COPD undergoing lung resection for cancer. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1519784DOI Listing
October 2018
12 Reads

Analysis of Autonomic Modulation in Response to a Session of Aerobic Exercise at Different Intensities in Patients With Moderate and Severe COPD.

COPD 2018 Oct 30:1-9. Epub 2018 Oct 30.

a Department of Physiotherapy , Universidade Estadual Paulista (UNESP) , São Paulo , Brazil.

Despite the many benefits of performing physical exercise in patients with chronic obstructive pulmonary disease (COPD), information on the response of acute cardiac autonomic modulation in subjects with moderate and severe COPD during and after an aerobic exercise session at different intensities is unknown. The aim of this study was to evaluate the response of cardiac autonomic modulation in patients with moderate and severe COPD during and after an aerobic exercise session at different intensities. Twenty-seven patients with COPD, divided into: Moderate Group and Severe Group, underwent an aerobic exercise sessions with intensities equivalent to 60% and 90% of velocity corresponding to peak oxygen consumption. Read More

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http://dx.doi.org/10.1080/15412555.2018.1529744DOI Listing
October 2018
12 Reads

Correction.

Authors:

COPD 2018 06 2;15(3):314-315. Epub 2018 Oct 2.

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http://dx.doi.org/10.1080/15412555.2018.1518204DOI Listing
June 2018
1 Read

Correction.

Authors:

COPD 2018 06 2;15(3):313. Epub 2018 Oct 2.

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http://dx.doi.org/10.1080/15412555.2018.1509830DOI Listing
June 2018
1 Read

Comorbidities and length of stay in chronic obstructive pulmonary disease patients.

COPD 2018 Jun-Aug;15(4):355-360. Epub 2018 Oct 1.

c University of North Carolina-Charlotte , Charlotte , North Carolina , USA.

Chronic Obstructive Pulmonary Disease (COPD) has a significant burden on patients and the healthcare system. There is a link between COPD and comorbidities such as congestive heart failure (CHF), fluid and electrolyte disorders, and renal failure. This adds to the complexity of healthcare in these patients. Read More

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http://dx.doi.org/10.1080/15412555.2018.1513470DOI Listing
October 2018
1 Read

The Efficacy and Safety of Once-daily Fluticasone Furoate/Umeclidinium/Vilanterol Versus Twice-daily Budesonide/Formoterol in a Subgroup of Patients from China with Symptomatic COPD at Risk of Exacerbations (FULFIL Trial).

COPD 2018 Sep 28:1-7. Epub 2018 Sep 28.

k GSK , King of Prussia , PA , USA.

The FULFIL study evaluated once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100 µg/62.5 µg/25 µg versus twice-daily budesonide/formoterol (BUD/FOR) 400 µg/12 µg in patients with symptomatic COPD at risk of exacerbations. FULFIL demonstrated clinically meaningful and statistically significant improvements at Week 24 in trough forced expiratory volume in 1 second (FEV), St George's Respiratory Questionnaire (SGRQ) Total scores and reduced exacerbation frequency. Read More

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http://dx.doi.org/10.1080/15412555.2018.1481022DOI Listing
September 2018
7 Reads

Prevalence and Predictors of Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease Undergoing Inpatient Pulmonary Rehabilitation.

COPD 2018 06 21;15(3):265-270. Epub 2018 Sep 21.

a Respiratory Intensive Care Unit and Pulmonary Rehabilitation Unit , Istituti Clinici Scientifici Maugeri IRCCS, Istituto Scientifico di Pavia , Pavia , Italy.

The aim of our study was to evaluate the prevalence and predictors of obstructive sleep apnea (OSA) in patients with chronic obstructive pulmonary disease (COPD) undergoing inpatient pulmonary rehabilitation programs (PRPs). A retrospective data review of consecutive stable patients with a known diagnosis of COPD, admitted for PRP between January 2007 and December 2013. Full overnight polysomnography (PSG) and Epworth Sleepiness Scale (ESS) were assessed in all patients. Read More

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http://dx.doi.org/10.1080/15412555.2018.1500533DOI Listing
June 2018
3 Reads

Differing Approaches to Managing the Chronic Breathlessness Syndrome in Advanced COPD: A Multi-National Survey of Specialists.

COPD 2018 06 11;15(3):294-302. Epub 2018 Sep 11.

f Palliative Medicine , St Vincent's Hospital and Victorian Comprehensive Cancer Centre, University of Melbourne.

This study explored the approaches of respiratory and palliative medicine specialists to managing the chronic breathlessness syndrome in patients with severe chronic obstructive pulmonary disease. A voluntary, online survey was emailed to all specialists and trainees in respiratory medicine in Australia and New Zealand (ANZ), and to all palliative medicine specialists and trainees in ANZ and the United Kingdom (UK). Five hundred and seventy-seven (33. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1502264DOI Listing
June 2018
11 Reads

Does Adherence to Domiciliary NIMV Decrease the Subsequent Hospitalizations Rates and Cost for Patients Diagnosed with COPD?

COPD 2018 06 6;15(3):303-309. Epub 2018 Sep 6.

a Chest Disease Department , Yedikule Research and Training Hospital for Chest Diseases and Chest Surgery , Istanbul , Turkey.

Domiciliary noninvasive mechanical ventilation (NIMV) is used for treating patients with hypercapnic chronic obstructive pulmonary disease (COPD). We aimed to evaluate the association between adherence to the treatment and subsequent hospitalizations and costs. Data from 54 (27 adherent; 27 non-adherent) patients with COPD who were undergoing NIMV treatment at home for 6 months. Read More

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http://dx.doi.org/10.1080/15412555.2018.1500532DOI Listing
June 2018
3 Reads

Sleep Disturbances in COPD are Associated with Heterogeneity of Airway Obstruction.

COPD 2018 Jun-Aug;15(4):350-354. Epub 2018 Sep 6.

a Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.MIS) , University of Palermo . Palermo , Italy.

Individuals with Chronic Obstructive Pulmonary Disease (COPD) experience sleep disturbances due to the impact of respiratory symptoms on sleep quality. We explored whether sleep disturbances in COPD are linked to heterogeneity of airway constriction. The impact of breathing problems on sleep quality was measured in consecutive COPD outpatients with the COPD and Asthma Sleep Impact Scale (CASIS) questionnaire. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1504015DOI Listing
September 2018
19 Reads

Integrated Care in Chronic Obstructive Pulmonary Disease and Rehabilitation.

COPD 2018 Sep 5:1-8. Epub 2018 Sep 5.

c Pulmonary and Critical Care , St Francis Hospital (Trinity) , Hartford , Connecticut , USA.

Individuals with advanced chronic obstructive pulmonary disease (COPD) often have complex medical problems that require more than simple pharmacological therapy to optimize outcomes. Comprehensive care is necessary to meet the substantial burdens, not just from the primary respiratory disease process itself, but also those imposed by its systemic manifestations and comorbidities. These problems are intensified in the peri-exacerbation period, especially for newly discharged patients. Read More

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http://dx.doi.org/10.1080/15412555.2018.1501671DOI Listing
September 2018
2 Reads

Clinician-Facilitated Physical Activity Intervention Versus Pulmonary Rehabilitation for Improving Physical Activity in COPD: A Feasibility Study.

COPD 2018 06 5;15(3):254-264. Epub 2018 Sep 5.

i Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences , Queens University Belfast , Belfast , UK.

Pulmonary rehabilitation (PR) may not suit all individuals with chronic obstructive pulmonary disease (COPD) and may not result in increased physical activity. Higher levels of physical activity are associated with reduced mortality and morbidity. The aim of this study was to assess the feasibility of conducting a trial to investigate the effectiveness of a clinician-facilitated physical activity intervention (PAI) versus PR in improving physical activity in patients with COPD referred to PR. Read More

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http://dx.doi.org/10.1080/15412555.2018.1486396DOI Listing
June 2018
8 Reads

Pulmonary Rehabilitation: Where We've Succeeded and Where We've Failed.

Authors:
Richard Casaburi

COPD 2018 06 5;15(3):219-222. Epub 2018 Sep 5.

a Rehabilitation Clinical Trials Center , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance , California , USA.

Pulmonary rehabilitation has been established as the standard of care for patients with symptomatic chronic obstructive pulmonary disease (COPD). Benefits include improvements in exercise tolerance, dyspnoea and quality of life; magnitude of benefit is generally greater than for any other COPD therapy. A wide range of professional organizations and standards documents have recommended pulmonary rehabilitation; benefits accrue across the spectrum of disease severity. Read More

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http://dx.doi.org/10.1080/15412555.2018.1503245DOI Listing
June 2018
1 Read

Oxygen Uptake and Lactate Kinetics in Patients with Chronic Obstructive Pulmonary Disease during Heavy Intensity Exercise: Role of Pedaling Cadence.

COPD 2018 06 29;15(3):283-293. Epub 2018 Aug 29.

b Rehabilitation Clinical Trials Center , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance , California , USA.

Oxygen uptake slow component ([Formula: see text]) is associated with lactate accumulation, likely a contribution of poorly oxidative muscle fibers. We aimed to test the hypothesis that higher muscle tension during slow pedaling rates would yield more prominent [Formula: see text] in healthy subjects, but not in COPD patients. Eight severe COPD patients and 8 age-matched healthy individuals performed 4 rest-heavy exercise transitions at 40 and 80 RPM. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1487391DOI Listing
June 2018
7 Reads

Response to the letter of Liccardi et al.

COPD 2018 Aug 2. Epub 2018 Aug 2.

a Department of Health Sciences, Health Psychology Section, University Medical Center Groningen , University of Groningen , Groningen , The Netherlands.

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http://dx.doi.org/10.1080/15412555.2018.1485638DOI Listing
August 2018
1 Read

Investigating Fractional Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease (COPD) and Asthma-COPD Overlap (ACO): A Scoping Review.

COPD 2018 Jun-Aug;15(4):377-391. Epub 2018 Aug 1.

a Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre , Montréal , Québec , Canada.

Chronic obstructive pulmonary disease (COPD) is the most common fixed airflow limitation. Individuals may present with the features of both asthma and COPD called asthma-COPD overlap (ACO) with more severity and worse health-related quality of life than COPD or asthma. One of the promising biomarkers that could be used in clinical practice to differentiate ACO from COPD is fractional exhaled nitric oxide (F). Read More

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http://dx.doi.org/10.1080/15412555.2018.1485637DOI Listing
August 2018
7 Reads

Neutrophilic Inflammation in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

COPD 2018 Jul 31:1-13. Epub 2018 Jul 31.

a Institute of Inflammation and Ageing , University of Birmingham , Birmingham , UK.

Current paradigms of chronic obstructive pulmonary disease (COPD) treatment suggest stratifying patients by their symptoms, utilising three main drug classes, but it is unclear if this approach will substantially alter the progression of the disease in the long term. More treatment options are needed which target the underlying pathology of the condition. Whilst many inflammatory cells are implicated in COPD, the neutrophil is by far the most abundant and has been extensively associated with disease pathogenesis. Read More

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http://dx.doi.org/10.1080/15412555.2018.1476475DOI Listing
July 2018
3 Reads

Value of Exhaled Nitric Oxide (FeNO) And Eosinophilia During the Exacerbations of Chronic Obstructive Pulmonary Disease Requiring Hospital Admission.

COPD 2018 Jul 31:1-8. Epub 2018 Jul 31.

d Department of Intensive Care , CIBERES of Respiratory Diseases (CIBERES) Hospital Universitario de Getafe , Getafe , Spain.

The aim of this study was to analyze whether FeNO levels in acute exacerbation of COPD (AECOPD) with hospital admission have better diagnostic value than eosinophilia in blood, and to evaluate its usefulness in predicting a better clinical response. An observational prospective study of patients with AECOPD was carried out. FeNO determinations were made on arrival at the emergency room (ER), at discharge and during stability 3-6 months after discharge. Read More

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http://dx.doi.org/10.1080/15412555.2018.1482532DOI Listing
July 2018
4 Reads

5th International Workshop on Lung Health-Poster Awards' Winners Abstracts.

Authors:

COPD 2018 04 29;15(2):93-95. Epub 2018 May 29.

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http://dx.doi.org/10.1080/15412555.2018.1473078DOI Listing
April 2018
2 Reads

Physical Inactivity, Functional Status and Exercise Capacity in COPD Patients Receiving Home-Based Oxygen Therapy.

COPD 2018 May 25:1-6. Epub 2018 May 25.

a Postgraduate Program in Internal Medicine , Federal University of Paraná , Curitiba , PR , Brazil.

Chronic obstructive pulmonary disease (COPD) has systemic consequences that lead to reduced physical activity in daily life (PADL). Little is known about PADL and its associations in individuals with COPD on home-based long-term oxygen therapy (LTOT). The objective of the study was to determine whether there is an association between severe physical inactivity and pulmonary function, fatigue, dyspnea, functional status and exercise capacity in individuals with COPD on home-based LTOT using electric oxygen concentrators and to investigate which of these variables could influence inactivity in these individuals. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1469608DOI Listing
May 2018
3 Reads

Bronchodilator Responses in Respiratory Impedance, Hyperinflation and Gas Trapping in COPD.

COPD 2018 May 25:1-9. Epub 2018 May 25.

a The Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research and Sydney Medical School , University of Sydney , NSW , Australia.

Hyperinflation, gas trapping and their responses to long-acting bronchodilator are clinically important in COPD. The forced oscillation technique (FOT) measures of respiratory system resistance and reactance are sensitive markers of bronchodilator response in COPD. The relationships between changes in resistance and reactance, and changes in hyperinflation and gas trapping, following long-acting bronchodilator (LA-BD) have not been studied. Read More

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http://dx.doi.org/10.1080/15412555.2018.1458217DOI Listing
May 2018
3 Reads

Rehabilitation of Patients with Coexisting COPD and Heart Failure.

COPD 2018 May 25:1-7. Epub 2018 May 25.

a Respiratory Rehabilitation Unit , Istituti Clinici Scientifici Maugeri, IRCCS Lumezzane , Brescia , Italy.

Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist, significantly reducing the patient's quality of life (QoL) and increasing morbidity, disability and mortality. For both diseases, a multidisciplinary disease-management approach offers the best outcomes and reduces hospital readmissions. In both conditions, muscle dysfunction may dramatically influence symptoms, exercise tolerance/performance, health status and healthcare costs. Read More

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http://dx.doi.org/10.1080/15412555.2018.1468427DOI Listing
May 2018
2 Reads

Impact of Chronic Obstructive Pulmonary Disease on Cognitive and Motor Performances in Dual-Task Walking.

COPD 2018 May 25:1-6. Epub 2018 May 25.

a Cliniques du Souffle , Service Recherche , Groupe 5 Sante, Lodeve , France.

When two tasks are performed simultaneously, they compete for attentional resources, resulting in a performance decrement in one or both tasks. Patients with attention disorders have a reduced ability to perform several tasks simultaneously (e.g. Read More

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http://dx.doi.org/10.1080/15412555.2018.1469607DOI Listing
May 2018
2 Reads

Chronic Obstructive Pulmonary Disease and Stroke.

COPD 2018 Jun-Aug;15(4):405-413. Epub 2018 May 10.

d University General Hospital , Department of Thoracic Medicine, Stavrakia , Heraklion , Greece.

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world and its incidence and prevalence is on the rise. It is evident that COPD is linked to cardiovascular disease. In the last years, several studies demonstrated that COPD may also be a risk factor for stroke, another major cause of death worldwide. Read More

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http://dx.doi.org/10.1080/15412555.2018.1464551DOI Listing
May 2018
55 Reads

Psychological Stress, Lung Function and Exacerbation Risk in COPD: Is an Increase of Cholinergic Tone a Possible Link?

COPD 2018 06 7;15(3):310-311. Epub 2018 May 7.

b Post-graduate School of Respiratory Medicine. Department of Experimental Medicine and Surgery , University of Rome "Tor Vergata" , Rome , Italy.

at a glance: On the hypothesis that psychological distress might interfere with airway reactivity in patients suffering of mild to moderate COPD through a cholinergic-mediated-bronchial reflex. Read More

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http://dx.doi.org/10.1080/15412555.2018.1459533DOI Listing
June 2018
4 Reads

Grading Severity of Productive Cough Based on Symptoms and Airflow Obstruction.

COPD 2018 04 26;15(2):206-213. Epub 2018 Apr 26.

b COPD Program , Lovelace Respiratory Research Institute , Albuquerque , NM , USA.

The binary approach to the diagnosis of Chronic Bronchitis (CB) is a major barrier to the study of the disease. We investigated whether severity of productive cough can be graded using symptoms and presence of fixed airflow obstruction (FAO), and whether the severity correlates with health status, exposures injurious to the lung, biomarkers of inflammation, and measures of airway wall thickening. Findings from a cross-sectional sample of 1,422 participants from the Lovelace Smokers Cohort (LSC) were validated in 4,488 participants from the COPDGene cohort (COPDGene). Read More

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http://dx.doi.org/10.1080/15412555.2018.1458218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239864PMC
April 2018
6 Reads

Mortality Related to Chronic Obstructive Pulmonary Disease and Co-morbidities in the United States, A Multiple Causes of Death Analysis.

COPD 2018 04 26;15(2):200-205. Epub 2018 Apr 26.

b Department of Internal Medicine , Howard University College of Medicine , Washington, DC , USA.

Chronic obstructive pulmonary disease (COPD) mortality based on the underlying cause of death (UCOD) underestimates disease burden. We aimed to determine the current COPD mortality rate, trends and the distribution of co-morbidities using United States (US) multiple-cause of death (MCOD) records. All 38,905,575 death certificates of decedents aged ≥45 years in the United States were analyzed for 1999-2015. Read More

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http://dx.doi.org/10.1080/15412555.2018.1454897DOI Listing
April 2018
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Asthma-COPD Overlap Phenotypes and Smoking :Comparative features of asthma in smoking or non-smoking patients with an incomplete reversibility of airway obstruction.

COPD 2018 04 23;15(2):130-138. Epub 2018 Apr 23.

a Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval , Québec , Canada.

The development of COPD features, such as an incomplete reversibility of airway obstruction (IRAO), in smoking or non-smoking asthmatic patients, a condition often named Asthma-COPD Overlap (ACO), has been recognized for decades. However, there is a need to know more about the sub-phenotypes of this condition according to smoking. This study aimed at comparing the clinical, physiological and inflammatory features of smoking and non-smoking asthmatic patients exhibiting IRAO. Read More

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http://dx.doi.org/10.1080/15412555.2017.1395834DOI Listing
April 2018
6 Reads

Biologic Drugs: A New Target Therapy in COPD?

COPD 2018 04 23;15(2):99-107. Epub 2018 Apr 23.

a NIHR Leicester Biomedical Research Centre, Institute for Lung Health, Department of Infection, Immunity & Inflammation , University of Leicester , Leicester , United Kingdom.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria based on the presence of fixed airflow obstruction and symptoms do not integrate the complex pathological changes occurring within the lung and they do not define different airway inflammatory patterns. The current management of COPD is based on 'one size fits all' approach and does not take the importance of heterogeneity in COPD population into account. Read More

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http://dx.doi.org/10.1080/15412555.2018.1437897DOI Listing
April 2018
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Early Changes in eDiary COPD Symptoms Predict Clinically Relevant Treatment Response at 12 Weeks: Analysis from the CRYSTAL Study.

COPD 2018 04 16;15(2):185-191. Epub 2018 Apr 16.

a Global Medical Affairs, Novartis Pharma AG , Basel , Switzerland.

Early detection of treatment response is important in the long-term treatment and management of patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated whether early improvement in symptoms, recorded in the first 7 or 14 days via an electronic diary (eDiary) compared with baseline, can predict clinically meaningful treatment responders at 12 weeks. CRYSTAL was a 12-week, randomized, open-label study that demonstrated the increased effectiveness of indacaterol/glycopyrronium (IND/GLY) or glycopyrronium (GLY), after a direct switch from on-going baseline therapies, in patients with symptomatic COPD and moderate airflow obstruction. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1445213DOI Listing
April 2018
5 Reads

Comparison of Effects of Endurance and Strength Training Programs in Patients with COPD.

COPD 2018 04 16;15(2):192-199. Epub 2018 Apr 16.

b Department of Medicine , Wake Forest University , Winston-Salem , North Carolina , USA.

Comparisons between endurance and strength training in chronic obstructive pulmonary disease (COPD) patients have produced equivocal findings when examining physical function and health-related quality of life (HRQL). One reason for these differences may be due to individual patient responses to the different training modalities.

Purpose: To compare changes in physical function and HRQL in a group of COPD patients completing both an endurance and a strength training program. Read More

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http://dx.doi.org/10.1080/15412555.2018.1446926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116518PMC
April 2018
4 Reads