78,888 results match your criteria COPD: Journal of Chronic Obstructive Pulmonary Disease [Journal]


Low-Dose Budesonide/Formoterol Counteracts Airway Inflammation and Improves Lung Function in COPD.

Am J Respir Crit Care Med 2018 Dec 12. Epub 2018 Dec 12.

Imperial College London & Royal Brompton Hospital, London, United Kingdom of Great Britain and Northern Ireland.

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December 2018
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Indacaterol/Glycopyrronium versus Salmeterol/Fluticasone in Patients with COPD-A Cost-Effectiveness Analysis in the Czech Republic.

Value Health Reg Issues 2018 Sep 27;16:112-118. Epub 2018 Oct 27.

Novartis s.r.o., Prague, Czech Republic.

Background: Chronic obstructive pulmonary disease (COPD) represents an illness with significant healthcare and societal impacts. Fixed combinations of long-acting beta-agonists (LABA) and inhaled corticosteroids have been used for COPD treatment as the standard of care for many years. A daily dose of indacaterol and glycopyrronium (IND/GLY) at 110/50 µg has recently been gaining attention due to its improved efficacy and tolerability versus the standard of care. Read More

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September 2018

Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib.

Target Oncol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

Background: Acquired epidermal growth factor receptor (EGFR) T790M mutation is the primary resistance mechanism to first-generation EGFR tyrosine kinase inhibitors (TKIs) used in advanced, EGFR mutation-positive non-small-cell lung cancer (NSCLC). Available data, predominantly in Asian patients, suggest that this mutation is also the major cause of resistance to the irreversible ErbB family blocker, afatinib. For EGFR T790M-positive patients who progress on EGFR TKI therapy, osimertinib is an effective treatment option. Read More

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December 2018

FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells.

Front Endocrinol (Lausanne) 2018 27;9:708. Epub 2018 Nov 27.

Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.

The hexosamine biosynthetic pathway (HBP) generates the substrate for the O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins. The HBP also serves as a stress sensor and has been reported to be involved with nuclear factor of activated T-cells (NFAT) activation, which can contribute to multiple cellular processes including cell metabolism, proliferation, and inflammation. In our previously published report, Fibroblast Growth Factor (FGF) 23, an important endocrine pro-inflammatory mediator, was shown to activate the FGFR4/phospholipase Cγ (PLCγ)/nuclear factor of activated T-cells (NFAT) signaling in chronic inflammatory airway diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Read More

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November 2018

A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls.

J Pain Res 2018 21;11:2981-2990. Epub 2018 Nov 21.

Symptoms Biology Unit, National Institute of Nursing Research (NINR), Bethesda, MD, USA.

Objectives: Fibromyalgia syndrome (FMS) is a chronic and often debilitating condition that is characterized by persistent fatigue, pain, bowel abnormalities, and sleep disturbances. Currently, there are no definitive prognostic or diagnostic biomarkers for FMS. This study attempted to utilize a novel predictive algorithm to identify a group of genes whose differential expression discriminated individuals with FMS diagnosis from healthy controls. Read More

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November 2018

Evaluating the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire.

Int J Chron Obstruct Pulmon Dis 2018 26;13:3837-3844. Epub 2018 Nov 26.

Pneumology Department, Hospital Universitari Vall d'Hebron/Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain,

Purpose: The aim of this study was to evaluate the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire and to determine the clinical variables that are related to CDLM scores.

Methods: This was an observational, cross-sectional, and multicenter study conducted in stable COPD patients. CDLM scores ranged from 0 to 5 and were transformed into a qualitative variable according to tertile values to compare patient characteristics. Read More

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November 2018

Digitalizing multidisciplinary pulmonary rehabilitation in COPD with a smartphone application: an international observational pilot study.

Int J Chron Obstruct Pulmon Dis 2018 23;13:3831-3836. Epub 2018 Nov 23.

Lung Center, Department of Internal Medicine, Cantonal Hospital St Gallen, St Gallen, Switzerland,

Background: Concerning COPD, pulmonary rehabilitation (PR) has a positive effect on disease progression and mortality, is cost-effective, and is a part of recommendations of international guidelines. Only a minority of patients profit from conventional PR due to a lack of resources, physicians' guideline adherence, or patients' motivation. Novel digital therapies like Kaia COPD, a smartphone application that digitizes PR in COPD, are promising solutions to fill this void. Read More

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November 2018

Long-term macrolide treatment for the prevention of acute exacerbations in COPD: a systematic review and meta-analysis.

Int J Chron Obstruct Pulmon Dis 2018 22;13:3813-3829. Epub 2018 Nov 22.

Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China,

Background: Acute exacerbation of COPD (AECOPD) is associated with an increased hospitalization and mortality. Azithromycin and erythromycin are the recommended drugs to reduce the risk of exacerbations. However, the most suitable duration of therapy and drug-related adverse events are still a matter of debate. Read More

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November 2018

Impact of chemotherapy in the prognosis of non-small-cell lung cancer patients with severe to very severe COPD.

Int J Chron Obstruct Pulmon Dis 2018 21;13:3805-3812. Epub 2018 Nov 21.

Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, People's Republic of China,

Background: The aim of the study was to investigate if first-line chemotherapy improves total survival time in non-small-cell lung cancer (NSCLC) patients complicated with severe to very severe COPD.

Materials And Methods: This retrospective observational clinical study included 267 consecutive NSCLC patients with COPD complications at the Department of Respiratory and Critical Care Medicine of Tianjin Chest Hospital between January 2009 and January 2018. Sixty-nine evaluable patients were included. Read More

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November 2018

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study.

Int J Chron Obstruct Pulmon Dis 2018 21;13:3791-3803. Epub 2018 Nov 21.

Department of Respiratory Medicine, Gansu Provincial Hospital, Lanzhou, China.

Background: The aim of this study was to disclose the correlation between the serum levels of hypoxia-inducible factor 1 alpha (HIF-1α) and IL-19 and stable COPD.

Methods: The serum levels of HIF-1α and IL-19 were tested by ELISA. The relationships between their levels and clinical parameters of stable COPD patients were analyzed by linear regression methods. Read More

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November 2018

miR-190a-5p participates in the regulation of hypoxia-induced pulmonary hypertension by targeting KLF15 and can serve as a biomarker of diagnosis and prognosis in chronic obstructive pulmonary disease complicated with pulmonary hypertension.

Int J Chron Obstruct Pulmon Dis 2018 20;13:3777-3790. Epub 2018 Nov 20.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People's Republic of China,

Purpose: miR-190a-5p expression alters dynamically in response to hypoxia. However, the role of miR-190a-5p expression in hypoxia-induced pulmonary hypertension (PH) remains unclear. We sought to correlate the miR-190a-5p expression levels with the severity, diagnosis, and prognosis of PH in relation to chronic obstructive pulmonary disease (COPD-PH). Read More

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November 2018

Impact of COPD on prognosis of lung cancer: from a perspective on disease heterogeneity.

Int J Chron Obstruct Pulmon Dis 2018 20;13:3767-3776. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China,

Background: COPD is an important comorbidity of lung cancer, but the impact of COPD on the outcomes of lung cancer remains uncertain. Because both COPD and lung cancer are heterogeneous diseases, we evaluated the link between COPD phenotypes and the prognosis of different histological subtypes of lung cancer.

Methods: In this retrospective study, subjects with a newly and pathologically confirmed diagnosis of lung cancer were enrolled from patients preparing for lung cancer surgery. Read More

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November 2018

Enhancing our understanding of the time course of acute exacerbations of COPD managed on an outpatient basis.

Int J Chron Obstruct Pulmon Dis 2018 20;13:3759-3766. Epub 2018 Nov 20.

Respiratory Research and Rehabilitation Laboratory Lab3R, School of Health Sciences, University of Aveiro, Aveiro, Portugal,

Purpose: Acute exacerbations of COPD (AECOPD) are associated with pulmonary/systemic changes; however, quantification of those changes during AECOPD managed on an outpatient basis and factors influencing recovery are lacking. This study aimed to characterize patients' changes during AECOPD and identify factors influencing their recovery.

Methods: Body mass index, the modified British Medical Research Council questionnaire, number of exacerbations in the previous year, and the Charlson comorbidity index (independent variables) were collected within 24-48 hours of hospital presentation (T0). Read More

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November 2018

A COPD Case-Finding Program in a Large Cohort of HIV-Infected Persons.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.

Background: COPD screening guidelines in patients with HIV are lacking, and data about its under-diagnosis are still limited. This study aimed to determinate the feasibility of a case-finding program and the prevalence of COPD under-diagnosis in a large cohort of HIV-infected subjects.

Methods: All out-patients attending their routine visit for HIV monitoring at Spedali Civili General Hospital in Brescia, Italy, from February 2015 to January 2016, were enrolled. Read More

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December 2018

Health beliefs and chronic illnesses of refugees: a systematic review.

Ethn Health 2018 Dec 11:1-13. Epub 2018 Dec 11.

a School of Health & Biomedical Sciences , RMIT University , Bundoora , Australia.

Objective: To evaluate beliefs, and attitudes about health of refugees with chronic conditions such as diabetes mellitus type 2, hypertension, chronic obstructive pulmonary disease, and posttraumatic stress disorder and the consequent effects on self-care in comparison to resident populations.

Design: A systematic review methodology was used. PubMed, Embase, PsycINFO and CINAHL databases were searched for relevant articles. Read More

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December 2018

Remote monitoring of implantable cardioverter defibrillators: Patient experiences and preferences for follow-up.

Pacing Clin Electrophysiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Patient satisfaction with remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) seems to be high, yet knowledge on long-term patient experiences is limited. The European REMOTE-CIED study explored patient experiences with RPM, examined patient preferences for ICD follow-up, and identified determinants of patient preferences in the first two years post-implantation.

Methods: European heart failure patients (N = 300; median age = 66 years (IQR = 59-73), and 22% female) with a first-time ICD received a Boston Scientific LATITUDE® RPM system and had scheduled in-clinic follow-ups once a year. Read More

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December 2018
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Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev 2018 Dec 11;12:CD011594. Epub 2018 Dec 11.

Faculty of Medicine, SEGi University, Hospital Sibu, Jalan Ulu Oya, Sibu, Sarawak, Malaysia, 96000.

Background: Several dual bronchodilator combinations of long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS). Fixed-dose combination (FDC) of aclidinium/formoterol is one of the approved LABA/LAMA therapies for people with stable COPD. Read More

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December 2018

Inflammasome in the Pathogenesis of Pulmonary Diseases.

Exp Suppl 2018 ;108:111-151

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. Read More

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January 2018

Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.

Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.

Nontypeable Haemophilus influenzae (NTHi) is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease (COPD). Here, we report the complete genome sequences of NTHi strains 10P129H1 and 84P36H1, isolated from COPD patients, which contain the phase-variable epigenetic regulators ModA15 and ModA18, respectively. Read More

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Role of microparticles derived from monocytes, endothelial cells and platelets in the exacerbation of COPD.

Int J Chron Obstruct Pulmon Dis 2018 15;13:3749-3757. Epub 2018 Nov 15.

Department of Anesthesiology and Intensive Therapy, University of Pécs, Medical School, Pécs, Hungary,

Background: Microparticles (MPs) are shedding membrane vesicles released from activated blood and endothelial cells under inflammatory conditions. The role of endothelial MPs (EMPs) in pathophysiology of COPD is relatively well known. However, the release and function of MPs of other cellular origins, eg, platelets, red blood cells and leukocytes, are not clearly evaluated in COPD. Read More

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November 2018

Identification of novel candidate genes involved in the progression of emphysema by bioinformatic methods.

Int J Chron Obstruct Pulmon Dis 2018 14;13:3733-3747. Epub 2018 Nov 14.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China,

Purpose: By reanalyzing the gene expression profile GSE76925 in the Gene Expression Omnibus database using bioinformatic methods, we attempted to identify novel candidate genes promoting the development of emphysema in patients with COPD.

Patients And Methods: According to the Quantitative CT data in GSE76925, patients were divided into mild emphysema group (%LAA-950<20%, n=12) and severe emphysema group (%LAA-950>50%, n=11). Differentially expressed genes (DEGs) were identified using Agilent GeneSpring GX v11. Read More

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November 2018

Validation of clinical control in COPD as a new tool for optimizing treatment.

Int J Chron Obstruct Pulmon Dis 2018 14;13:3719-3731. Epub 2018 Nov 14.

CIBER of Respiratory Diseases (CIBERES), Spain,

Background: It has recently been proposed that the concept of clinical control in COPD may be useful for deciding treatment in COPD, but the original control criteria (OCC) were considered too restrictive.

Objective: Define and subsequently validate "modified" control criteria (MCC) of COPD.

Method: Prospective observational study in COPD patients with a 1-year follow-up. Read More

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November 2018

Towards quantitative perfusion MRI of the lung in COPD: The problem of short-term repeatability.

PLoS One 2018 10;13(12):e0208587. Epub 2018 Dec 10.

Department of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.

Purpose: 4D perfusion magnetic resonance imaging (MRI) with intravenous injection of contrast agent allows for a radiation-free assessment of regional lung function. It is therefore a valuable method to monitor response to treatment in patients with chronic obstructive pulmonary disease (COPD). This study was designed to evaluate its potential for monitoring short-term response to hyperoxia in COPD patients. Read More

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December 2018
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Comparison of Inpatient and Outpatient Preoperative Factors and Postoperative Outcomes in 2-Level Cervical Disc Arthroplasty.

Neurospine 2018 Sep 9. Epub 2018 Sep 9.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Objective: The purpose of this study was to evaluate factors associated with inpatient admission following 2-level cervical disc arthroplasty (CDA). A secondary aim was to compare outcomes between those treated on an inpatient versus outpatient basis.

Methods: Using data from the American College of Surgeons National Surgical Quality Improvement Program database, multivariate logistic regression analysis was used to assess the independent effect of each variable on inpatient or outpatient selection for surgery. Read More

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September 2018

Functional Status is Associated With 30-Day Potentially Preventable Readmissions Following Home Health Care.

Med Care 2018 Dec 10. Epub 2018 Dec 10.

Division of Rehabilitation Sciences.

Background: Beginning in 2019, home health agencies' rates of potentially preventable hospital readmissions over the 30 days following discharge will be publicly reported.

Objectives: Our primary objective was to determine the association between patients' functional status at discharge from home health care and 30-day potentially preventable readmissions. A secondary objective was to identify the most common conditions resulting in potentially preventable readmissions. Read More

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December 2018
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Cardiorespiratory and Muscle Oxygenation Responses to Isokinetic Test in COPD.

Med Sci Sports Exerc 2018 Dec 5. Epub 2018 Dec 5.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Québec, CANADA.

Purpose: To describe cardiorespiratory, quadriceps oxygenation, and muscle fatigue responses during a one-legged quadriceps isokinetic endurance exercise in COPD and control subjects.

Methods: Fourteen patients with COPD and 14 control subjects performed a cardiopulmonary cycling exercise test (CPET) to exhaustion to assess peak oxygen consumption (V˙O2peak), minute ventilation (V˙E2peak) and heart rate (HRpeak). They also performed a quadriceps isokinetic endurance exercise consisting in 30 maximal knee-extensions at 90°/s with continuous monitoring of expired gases, cardiac output (CO) and oxygenation of the quadriceps by near-infrared spectroscopy. Read More

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December 2018

Physical Activity Is Associated with Attenuated Disease Progression in COPD.

Med Sci Sports Exerc 2018 Dec 7. Epub 2018 Dec 7.

ISGlobal, Barcelona, Spain[ZERO WIDTH SPACE].

Introduction: COPD progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression.

Method: We studied 114 COPD patients from the PAC-COPD cohort [94% male, mean (SD) 70 (8) years of age, 54 (16) FEV1 % predicted] at baseline and 2. Read More

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December 2018

Paradigm changes for diagnosis: using big data for prediction.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care. Read More

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December 2018

TGF-β Upregulated Mitochondria Mass through the SMAD2/3→C/EBPβ→PRMT1 Signal Pathway in Primary Human Lung Fibroblasts.

J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Pneumology and Pulmonary Cell Research, Department of Biomedicine, University of Basel and University Hospital Basel, CH-4031 Basel, Switzerland; and

Tissue remodeling of subepithelial mesenchymal cells is a major pathologic condition of chronic obstructive pulmonary disease and asthma. Fibroblasts contribute to fibrotic events and inflammation in both airway diseases. Recent mechanistic studies established a link between mitochondrial dysfunction or aberrant biogenesis leading to tissue remodeling of the airway wall in asthma. Read More

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December 2018

Correction: .

Authors:

BMJ Open 2018 Dec 9;8(12):e022051corr1. Epub 2018 Dec 9.

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December 2018

Effects of ambient benzene and toluene on emergency COPD hospitalizations: A time series study in Hong Kong.

Sci Total Environ 2018 Dec 4;657:28-35. Epub 2018 Dec 4.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China. Electronic address:

Background: Although numerous studies have demonstrated that the criteria air pollutants increased the risk of exacerbation of chronic obstructive pulmonary disease (COPD), few have explored the effects of ambient benzene and toluene on COPD.

Objective: This study aimed to evaluate the short-term effects of ambient benzene and toluene on emergency COPD (eCOPD) hospitalizations.

Methods: We obtained daily mean and maximum concentrations of benzene and toluene during April 1, 2011 - December 31, 2014 from the Hong Kong Environmental Protection Department, and daily counts of eCOPD hospitalizations from the Hospital Authority. Read More

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December 2018

The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation.

Heart Lung Circ 2018 Nov 30. Epub 2018 Nov 30.

The Heart Centre, Royal Stoke Hospital, University Hospital of North Midlands Trust, Stoke-on-Trent, UK; Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK.

Background: Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of comorbid conditions in patients undergoing TAVI using the Charlson Comorbidity Index (CCI) and to assess their impact on clinical and procedural outcomes.

Methods: We analysed 158 patients who underwent a TAVI at our institution between June 2009 and September 2015 to define their co-morbid burden as measured with CCI, and study its impact on procedural characteristics and mortality at 30 days. Read More

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November 2018
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Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 4. Epub 2018 Dec 4.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.

Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators here collectively named oxylipins. These include classical eicosanoids, but also pro-resolving mediators. Read More

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December 2018

Effect of critical care complications on perioperative mortality and hospital length of stay after hepatectomy: A multicenter analysis of 21,443 patients.

Am J Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery - Transplant Division, University of Kentucky, College of Medicine, Lexington, KY, 40536, USA. Electronic address:

Objective: To determine predictors of critical care complications (CCC) in patients undergoing hepatectomy.

Methods: All hepatectomy patients in NSQIP from 2012 to 2016 were analyzed. CCC included prolonged ventilation (>48 h), sepsis/septic shock, renal failure/insufficiency, cardiac arrest/AMI and pulmonary embolism. Read More

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November 2018

[Living with Chronic Illness Scale: Pilot study in patients with several chronic diseases].

Aten Primaria 2018 Dec 7. Epub 2018 Dec 7.

Centro Nacional de Epidemiología y CIBERNED, Instituto de Salud Carlos III, Madrid, España.

Objective: To present the pilot study of the Living with Chronic Illness Scale (EC-PC) in patients with diabetes mellitus type 2, chronic heart failure, chronic obstructive pulmonary disease and osteoarthritis.

Design: Observational, cross-sectional and multicenter study.

Location: Two specialized hospitals in Navarre and Madrid. Read More

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December 2018

Common femoral artery antegrade and retrograde approaches have similar access site complications.

J Vasc Surg 2018 Dec 4. Epub 2018 Dec 4.

Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass.

Objective: Ipsilateral antegrade access (AA) is an alternative access option for contralateral retrograde access (RA) in treating infrainguinal occlusive disease. Our goal was to assess whether AA is associated with higher access site complications.

Methods: The Vascular Quality Initiative database was searched from 2010 to 2017 for all infrainguinal peripheral vascular interventions. Read More

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December 2018

Erratum to "Clinical and molecular markers in COPD" [Pulmonology 24 (4) (2018) 250-259].

Pulmonology 2018 Dec 4. Epub 2018 Dec 4.

Pulmonology Department, Hospital Pedro Hispano, Matosinhos, Portugal. Electronic address:

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December 2018

COPD and Cardiovascular Disease.

Pulmonology 2018 Dec 6. Epub 2018 Dec 6.

Pulmonology Department, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, EPE (CHLC), Lisbon, Portugal; Nova Medical School, Nova University, Lisbon, Portugal. Electronic address:

COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020. COPD and cardiac comorbidities are frequently associated. Read More

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December 2018

Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study.

Schizophr Res 2018 Dec 5. Epub 2018 Dec 5.

Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Introduction: People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality.

Method: A register-based retrospective nested case-control study was conducted, identifying incident cases of cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), cancer and diabetes, as well as mortality due to these diseases, across the lifespan in schizophrenia. Read More

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December 2018

COUNTERPOINT: Should Chest CT Be Part of Routine Clinical Care for COPD? No.

Authors:
MeiLan K Han

Chest 2018 Dec;154(6):1278-1281

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI. Electronic address:

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December 2018

POINT: Should Chest CT Be Part of Routine Clinical Care for COPD? Yes.

Authors:
George R Washko

Chest 2018 Dec;154(6):1276-1278

Lung Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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December 2018

Asthma/COPD Overlap: A Gene by Environment Interaction?

Chest 2018 Dec;154(6):1270-1271

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Colege of Medicine, Tucson, University of Arizona Health Sciences, Tucson, AZ. Electronic address:

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December 2018

Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking.

Respir Res 2018 Dec 7;19(1):244. Epub 2018 Dec 7.

Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, 90187, Umeå, Sweden.

Background: Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in lung function.

Methods: Bronchoscopy with BAL was performed in 52 subjects recruited from the longitudinal OLIN COPD study according to pre-determined criteria; 12 with COPD and a rapid decline in lung function (loss of FEV ≥ 60 ml/year), 10 with COPD and a non-rapid decline in lung function (loss of FEV ≤ 30 ml/year), 15 current and ex-smokers and 15 non-smokers with normal lung function. Read More

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December 2018
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PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD).

BMC Cancer 2018 Dec 10;18(1):1238. Epub 2018 Dec 10.

Airways Disease, National Heart and Lung Institute, Imperial College London, London, UK.

Background: COPD patients are at increased risk of developing non-small cell lung carcinoma that has a worse prognosis. Oxidative stress contributes to carcinogenesis and is increased in COPD patients due to mitochondrial dysfunction. We determined whether mitochondrial dysfunction is a contributing factor to the reduced survival of COPD patients with non-small cell lung carcinoma (NSCLC). Read More

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December 2018

T-cell immunology of the lung: maintaining the balance between host defence and immune pathology.

Authors:
Daniel M Altmann

Immunology 2019 Jan;156(1):1-2

Department of Medicine, Hammersmith Hospital, London, UK.

Respiratory immunology poses the dual questions of how to grapple with lung infection as one of the greatest unmet global health needs of our time, while also dealing with the growing challenge posed by chronic diseases of excessive or inappropriate lung inflammation and immunity, such as chronic obstructive lung disease and asthma. These separate branches of pulmonary research are linked by the clear observation that, in a tissue as fragile as the lung, protection from microbial attack may come at the cost of chronic inflammatory damage. A number of recent studies have considered specific aspects of this double-edged sword, including the diversity of responses to fungal exposure, sources and consequences of interleukin-17 immunity, and the role of tertiary lymphoid follicles in the lung. Read More

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January 2019
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Cost of medical attention in patients with Chronic Obstructive Pulmonary Disease

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):371-378. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Unidad de Investigación Epidemiológica y en Servicios de Salud. Querétaro, Querétaro, México

Background: The chronic obstructive pulmonary disease is a preventable entity, when it develops the patient suffers severe complications, with a high economic impact for the patient and for health services.

Objetive: To determine the cost of medical care in patients with chronic obstructive pulmonary disease (COPD).

Methods: Using a cost design, the files of patients with COPD who attended the pulmonology clinic were analyzed. Read More

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November 2018

Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis.

Cochrane Database Syst Rev 2018 Dec 3;12:CD012620. Epub 2018 Dec 3.

Division of Pulmonary and Critical Care Medicine, University of Missouri, Columbia, MO, USA.

Background: Long-acting bronchodilators such as long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA), and LABA/inhaled corticosteroid (ICS) combinations have been used in people with moderate to severe chronic obstructive pulmonary disease (COPD) to control symptoms such as dyspnoea and cough, and prevent exacerbations. A number of LABA/LAMA combinations are now available for clinical use in COPD. However, it is not clear which group of above mentioned inhalers is most effective or if any specific formulation works better than the others within the same group or class. Read More

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December 2018
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Variability of arterial and peripheral venous blood gases parameters in subjects with stable obstructive pulmonary disease

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):342-346. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Cardiología, Departamento de Hipertensión Pulmonar y Corazón Derecho. Ciudad de México, México

Background: Peripheral venous blood gases may be useful in subjects with exacerbation of chronic obstructive pulmonary disease to evaluate their gas exchange.

Objective: To describe the variability of parameters of arterial and peripheral venous blood gases in subjects with stable obstructive pulmonary disease.

Methods: Cross-sectional design, consecutive subjects were studied in a blinded manner, while arterial and peripheral venous blood was obtained for analysis. Read More

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November 2018

Biomarkers for chronic obstructive pulmonary disease diagnosis and progression: insights, disappointments and promise.

Authors:
David M Mannino

Curr Opin Pulm Med 2018 Dec 4. Epub 2018 Dec 4.

Medical Affairs, GlaxoSmithKline, Philadelphia, Pennsylvania.

Purpose Of Review: This article reviews the status of biomarkers useful in the diagnosis and progression of chronic obstructive pulmonary disease (COPD). Biomarkers have been the focus of a great deal of COPD-related research in recent years, although useful markers in these specific arenas remain elusive.

Recent Findings: No biomarker other than lung function has been shown to be useful, to date, for the diagnosis of COPD. Read More

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December 2018
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A Functional Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism is Associated with Reduced Diffusing Capacity.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pulmonary and Critical Care, Yale University School of Medicine, United States.

Cigarette smoke exposure is the leading modifiable risk factor for COPD, however the clinical and pathologic consequences of chronic cigarette smoke exposure are variable amongst smokers. MIF (Macrophage Migration Inhibitory Factor) is a pleiotropic cytokine implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT microsatellite repeat) ( rs5844572). Read More

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December 2018