113,004 results match your criteria CNS & Neurological Disorders - Drug Targets [Journal]


Long-term treatment with kefir probiotics ameliorates cardiac function in spontaneously hypertensive rats.

J Nutr Biochem 2019 Jan 18;66:79-85. Epub 2019 Jan 18.

Department of Pharmacy, University Vila Velha, Vila Velha, ES, Brazil. Electronic address:

This work evaluated the effects of long-term kefir treatment in cardiac function (cardiac contractility and calcium-handling proteins) and the central nervous system (CNS) control of the sympathetic signaling in spontaneously hypertensive rats (SHR). Male normotensive rats [Wistar Kyoto rats (WKYs)] and SHRs were divided into three groups: WKYs and SHRs treated with vehicle, and SHRs treated with milk fermented by the grains of kefir (5%; SHR-Kefir; oral gavage, 0.3 ml/100 g daily/9 weeks). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jnutbio.2019.01.006DOI Listing
January 2019

Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease. A systematic review.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019

Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA.

Background: Brain insulin resistance is a well-recognized abnormality in Alzheimer's disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity.

Objective: This study was designed to determine whether systemic and central nervous system (CNS) insulin resistant disease states emerge together and thus may be integrally related. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180906DOI Listing
February 2019

Scalable synthesis of FeS nanoparticles encapsulated into N-doped carbon nanosheets as a high-performance sodium-ion battery anode.

Nanoscale 2019 Feb 18. Epub 2019 Feb 18.

School of Materials Science & Engineering, Georgia Institute of Technology, 771 Ferst Drive, Atlanta, GA 30332-0245, USA.

Pyrite (FeS2) has been considered as one of the most potential anode materials for sodium ion batteries (SIBs) due to its low cost, environmentally friendly features and high theoretical capacity. However, the huge volume changes during a charge/discharge process and poor conductivity of FeS2 hindered its practical applications. Herein, we propose a facile scalable approach to prepare nanostructured FeS2 embedded in an N-doped carbon nanosheet composite (FeS2/CNS) via a combined template method and a solid state sulfuration method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8nr10444aDOI Listing
February 2019

The effect of enzyme replacement therapy on clinical outcomes in male patients with Fabry disease: A systematic literature review by a European panel of experts.

Mol Genet Metab Rep 2019 Jun 6;19:100454. Epub 2019 Feb 6.

Department of Paediatrics, University of Torino, Torino, Italy.

Background: Enzyme replacement therapy (ERT) with recombinant human α-galactosidase has been available for the treatment of Fabry disease since 2001 in Europe and 2003 in the USA. Treatment outcomes with ERT are dependent on baseline patient characteristics, and published data are derived from heterogeneous study populations.

Methods: We conducted a comprehensive systematic literature review of all original articles on ERT in the treatment of Fabry disease published up until January 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgmr.2019.100454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365982PMC

Stereotactic radiosurgery for the treatment of brain metastasis from gastrointestinal primary cancers.

J Radiosurg SBRT 2019 ;6(1):27-34

Department of Radiation Oncology, 251 E. Huron St. Galter Pavilion, Chicago, IL 60611, USA.

Purpose: We aimed to determine the efficacy of gamma knife stereotactic radiosurgery (SRS) to control brain metastases (BM) from GI primaries and report on the patient outcomes.

Materials/methods: We retrospectively evaluated patients who had undergone SRS at our institution for the treatment BM from GI primaries from 2000 to 2016. Actuarial rates for overall survival (OS) and local control (LC) were calculated. Read More

View Article

Download full-text PDF

Source
January 2019

Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy.

Transl Neurodegener 2019 6;8. Epub 2019 Feb 6.

1Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.

Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (αS) transgenic mice, Line G2-3, develops αS-driven neurological and motor impairments after 9 months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40035-019-0146-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364448PMC
February 2019

Central nervous system infection mimicking central nervous system idiopathic inflammatory demyelinating disease.

Infect Drug Resist 2019 22;12:255-259. Epub 2019 Jan 22.

Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China,

(Lm) is an opportunistic pathogen that causes life-threatening infections, especially when the central nervous system (CNS) is involved. Here, we report a patient who was admitted to the hospital with headache, dizziness, right side facial numbness, and hoarseness. The individual was initially diagnosed with central nervous system idiopathic inflammatory demyelinating disease (CNS IIDD), which was then found to be CNS Lm infection (brainstem and cervical cord infection). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IDR.S189930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348973PMC
January 2019

Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors.

J Vis Exp 2019 Jan 29(143). Epub 2019 Jan 29.

VIB-KU Leuven Center for Brain and Disease Research; Department of Neuroscience, KU Leuven; Leuven Brain Institute;

Gene delivery tools based on adeno-associated viruses (AAVs) are a popular choice for the delivery of transgenes to the central nervous system (CNS), including gene therapy applications. AAV vectors are non-replicating, able to infect both dividing and non-dividing cells and provide long-term transgene expression. Importantly, some serotypes, such as the newly described PHP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/58960DOI Listing
January 2019

A standard operating procedure for King's ALS clinical staging.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Feb 18:1-6. Epub 2019 Feb 18.

c Department of Basic and Clinical Neuroscience , Maurice Wohl Clinical Neuroscience Institute, King's College London , London , UK.

Objective: Clinical stages in amyotrophic lateral sclerosis (ALS) can be measured using a simple system based on the number of CNS regions involved and requirement for gastrostomy or noninvasive ventilation (NIV). We aimed to design a standard operating procedure (SOP) to define the standardized use and application of the King's staging system.

Methods: We designed a SOP for the King's staging system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1556696DOI Listing
February 2019

Rosai-Dorfman disease with spinal and multiple intracranial involvement: a case report and literature review.

Br J Neurosurg 2019 Feb 18:1-5. Epub 2019 Feb 18.

b Department of Pathology , People's Hospital of Guangxi Zhuang Autonomous Region , Nanning , Guangxi , China.

Rosai-Dorfman disease (RDD) is a condition of unknown etiology, and characterized by the proliferation of histiocytes. RDD most commonly affects lymph nodes, and central nervous system (CNS) involvement is rare. Here, we describe the case of a 43-year-old man who presented with an intradural tumour of the thoracic spine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02688697.2019.1567681DOI Listing
February 2019

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy.

Adv Mater 2019 Feb 17:e1805697. Epub 2019 Feb 17.

Department of Neurosurgery, Tianjin Medical University General Hospital; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin Neurological Institute, Tianjin, 300052, China.

As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class of powerful therapeutics for treatment of a broad range of diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability to enter the CNS. A platform technology is reported here that enables effective delivery of mAbs to the CNS for brain tumor therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201805697DOI Listing
February 2019

Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.

Bioorg Med Chem Lett 2019 Jan 30. Epub 2019 Jan 30.

Translational Science, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France.

In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson's disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2019.01.024DOI Listing
January 2019

Long-Term Evaluation of Combination Treatment of Single Agent HD-MTX Chemotherapy up to Three Cycles and Moderate Dose Whole Brain Irradiation for Primary CNS Lymphoma.

J Chemother 2019 Feb;31(1):35-41

b Department of Radiation Medicine , Hokkaido University Faculty of Medicine , Sapporo , Japan.

High-dose methotrexate (HD-MTX)-based chemotherapy in combination with whole brain radiotherapy (WBRT) has been a common therapy for primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the survival benefit of a minimized cycle of HD-MTX monotherapy prior to WBRT. A maximum of three cycles of HD-MTX was combined with a WBRT dose of 30 Gy and an additional localized boost was administered where remnant was observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1120009X.2018.1546984DOI Listing
February 2019

Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.

Sleep Med 2018 Dec 26;55:74-80. Epub 2018 Dec 26.

European Sleep Institute, Santiago, Chile. Electronic address:

Objectives: To determine whether long-term treatment with dopaminergic agents (DAs) might dampen the response to a non-dopaminergic agent, such as gabapentin enacarbil.

Methods: We performed a two-week randomized, double-blind, crossover, and placebo-controlled study in a single, referral center in dopamine treatment-naive patients and non-augmented patients continuously treated with dopaminergics for the last five consecutive years. Following washout from any previous CNS-active drugs, patients were randomized into one of two groups for two consecutive two-week treatment periods with gabapentin enacarbil (GBPen) and placebo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2018.11.025DOI Listing
December 2018

Nonmedical prescription psychiatric drug use and the darknet: A cryptomarket analysis.

Int J Drug Policy 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.

Background: Nonmedical prescription psychiatric drug use (NMPDU) is an increasing global health problem, with recent concern focusing on darknet cryptomarkets as sources of procurement. There is a shortage of evidence regarding comparative worldwide NMPDU trends, due in part to data collection difficulties. This problem is particularly marked for non-opioid drugs, particularly those psychiatric drugs which act on the central nervous system (CNS) and have high misuse potential and are associated with high levels of dependency and fatal overdose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugpo.2019.01.016DOI Listing
February 2019

Milk haptoglobin detection based on enhanced chemiluminescence of gold nanoparticles.

Talanta 2019 May 8;197:257-263. Epub 2019 Jan 8.

Institute of Agricultural Engineering, ARO, The Volcani Center, Bet Dagan 50250, Israel. Electronic address:

The suggested research specifically addresses the major source of economic loss of the dairy industry, the bovine mastitis (BM), an inflammatory disease of mammary gland caused by bacterial intramammary infection. During udder inflammation, the concentrations of acute phase proteins (APP) in both plasma and milk are escalated, which can be distinctively utilized as predicting diagnostic biomarkers of cattle's BM clinical status. Herein, we demonstrate a liquid-phase luminol chemiluminescence (CL) system for sensitive detection of haptoglobin (Hp), a predictive APP of BM, by utilizing the binding capacity of hemoglobin (Hb). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.talanta.2019.01.027DOI Listing

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis. The fact that medulloblastomas rarely metastasize outside the CNS but rather spread almost exclusively to the spinal and intracranial leptomeninges has fostered the long-held belief that medulloblastoma cells spread directly through the CSF, not the bloodstream. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019
1 Read

Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease.

Mult Scler Relat Disord 2019 Feb 8;30:123-128. Epub 2019 Feb 8.

Navy Clinical College, Anhui Medical University, Hefei, 230032 Anhui, China; Department of Neurology, The Sixth Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, 100048 China. Electronic address:

Background: Central nervous system (CNS) inflammatory demyelinating disease (IDD) is an immune-mediated disease that is pathologically characterized by demyelination and inflammatory infiltration in the CNS and includes clinically isolated syndrome (CIS), multiple sclerosis (MS), and neuromyelitis optica spectrum disorders (NMOSD). IDD is usually characterized by variable symptoms, multivariate imaging, uncertain reactions to treatment, and a variable prognosis, which makes it difficult to diagnose early. In recent years, the role of the neurofilament light chain (NFL), an axonal injury biomarker, in IDD has become increasingly important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2019.02.009DOI Listing
February 2019

Aquaporin-4 antibody positive short transverse myelitis associated with breast cancer.

Mult Scler Relat Disord 2019 Feb 8;30:119-122. Epub 2019 Feb 8.

Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS). A typical finding on spinal magnetic resonance imaging (MRI) of NMOSD is longitudinally extensive transverse myelitis (LETM). However, patients with NMOSD presenting with short-segment transverse myelitis (STM) during myelitis attacks associated with breast cancer are uncommon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2019.02.011DOI Listing
February 2019

Foxp3+ regulatory T cells expression in neuromyelitis optica spectrum disorders.

Mult Scler Relat Disord 2019 Jan 30;30:114-118. Epub 2019 Jan 30.

Department of Neurology and the Multiple Sclerosis Center, the Agnes-Ginges Center for Neurogenetics, Hadassah- Medical Center, Hebrew University, Ein Karem, P.O.B. 12000, Jerusalem 91120, Israel. Electronic address:

Background: Alterations in the frequency or function of regulatory T cells (Tregs), which play a critical role in the maintenance of peripheral immune tolerance, are known to be involved in the pathogenesis of several autoimmune diseases. Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune inflammatory diseases of the central nervous system (CNS), of which the etiology and mechanisms underlying its development are not completely understood. Although there is increasing evidence for the involvement of effector T cells in NMOSD, no data are available regarding the role of Tregs in its pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2019.01.047DOI Listing
January 2019

Cumulative multiple early life hits- a potent threat leading to neurological disorders.

Brain Res Bull 2019 Feb 13. Epub 2019 Feb 13.

School of Studies in Neuroscience, Jiwaji University, Gwalior, India; School of Studies in Zoology, Jiwaji University, Gwalior, India. Electronic address:

Early life Stress is a worldwide concern linked with development of later life neurological disorder. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.02.005DOI Listing
February 2019

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Methods Mol Biol 2019 ;1948:45-57

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common feature found in several neurodegenerative disorders including Parkinson's disease (PD). Emerging evidence indicates that aSyn amyloid fibrils, a configuration that is present within these characteristic inclusions, are capable of self-replicating by templating the conversion of endogenously expressed aSyn in neurons. Stereotaxic administration of synthetic α-synuclein preformed fibrils (PFFs) into the mouse brain has been shown to seed the formation of intracellular aSyn pathology reminiscent of Lewy body (LB) inclusions present in human PD and related synucleinopathies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9124-2_5DOI Listing
January 2019

CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys.

Cell Res 2019 Feb 15. Epub 2019 Feb 15.

Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, 510632, Guangzhou, Guangdong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41422-019-0142-yDOI Listing
February 2019

Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103 dendritic cell differentiation.

Nat Commun 2019 Feb 15;10(1):862. Epub 2019 Feb 15.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

The original version of this Article contained errors in the author affiliations. Qingnan Zhao, Xueqing Xia, Longfei Huo and Shulin Li were incorrectly associated with Beijing Institute for Brain Disorders, 100069, Beijing, China.This has now been corrected in both the PDF and HTML versions of the Article. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-019-08770-5
Publisher Site
http://dx.doi.org/10.1038/s41467-019-08770-5DOI Listing
February 2019
1 Read
10.742 Impact Factor

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment.

Arthritis Res Ther 2019 Feb 15;21(1):60. Epub 2019 Feb 15.

Rheumatology Unit, Department of Medicine, Solna, Center of Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, SE-17176, Stockholm, Sweden.

Background: Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF blockade. We therefore investigated the effects of TNF blockade on the arthritis CSF proteome and how candidate proteins related to clinical measures of disease activity and inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-019-1846-6DOI Listing
February 2019

Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis.

Brain 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, Japan.

The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS), characterized by accumulating fixed disability, is yet to be fully understood. Although alterations in the gut microbiota have recently been highlighted in multiple sclerosis pathogenesis, the mechanism linking the altered gut environment with the remote CNS pathology remains unclear. Here, we analyse human CD4+ memory T cells expressing the gut-homing chemokine receptor CCR9 and found a reduced frequency of CCR9+ memory T cells in the peripheral blood of patients with SPMS relative to healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awz012DOI Listing
February 2019

Molecular Control of Oligodendrocyte Development.

Trends Neurosci 2019 Feb 12. Epub 2019 Feb 12.

The Center for Peripheral Neuropathy, The Department of Neurology, University of Chicago, Chicago, IL, USA. Electronic address:

Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for the efficient propagation of action potentials. During developmental myelination of the central nervous system (CNS), oligodendrocyte progenitor cells (OPCs) proliferate and migrate to their final destination, where they terminally differentiate into mature oligodendrocytes and myelinate axons. Lineage progression and terminal differentiation of oligodendrocyte lineage cells are under tight transcriptional and post-transcriptional control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2019.01.002DOI Listing
February 2019

Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.

Brain Res Bull 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.02.003DOI Listing
February 2019

A multidimensional concept for mercury neuronal and sensory toxicity in fish - from toxicokinetics and biochemistry to morphometry and behavior.

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Background: Neuronal and sensory toxicity of mercury (Hg) compounds has been largely investigated in humans/mammals with a focus on public health, while research in fish is less prolific and dispersed by different species. Well-established premises for mammals have been governing fish research, but some contradictory findings suggest that knowledge translation between these animal groups needs prudence [e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2019.01.020DOI Listing
February 2019
4.381 Impact Factor

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response.

J Neurosci Methods 2019 Feb 12. Epub 2019 Feb 12.

Mylan School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, PA, USA. Electronic address:

Background: Challenges specific to the discovery and development of candidate CNS drugs have led to implementation of various in silico, in vitro and in vivo approaches to improve the odds for commercialization of novel treatments.

New Method: Advances in analytical methodology and microdialysis probe design have enabled development of a non-human primate model capable of measuring concentrations of drugs or endogenous chemicals in brain extracellular fluid (ECF) and cerebrospinal fluid (CSF). Linking these to population modeling reduces animal numbers to support predictive translational sciences in primates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2019.02.005DOI Listing
February 2019

Iatrogenic CNS demyelination in the era of modern biologics.

Mult Scler 2019 Feb 15:1352458519828601. Epub 2019 Feb 15.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Multiple Sclerosis and Neuroimmunology Program, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

The number of reported cases of iatrogenic demyelination of the central nervous system (CNS) is on the rise. This is, in part, related to the recent expansion in the use of biologics. Review of literature from the past decade suggests that in addition to vaccines, tumor necrosis factor (TNF)-alpha inhibitors and checkpoint inhibitors are the most frequently cited inducers of central inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519828601DOI Listing
February 2019
1 Read

Isolation and characterization of cerebellum-derived stem cells in post-stroke human brain.

Stem Cells Dev 2019 Feb 15. Epub 2019 Feb 15.

Hyogo College of Medicine, 12818, Nishinomiya, Hyogo, Japan ;

There is compelling evidence that the mature central nervous system (CNS) harbors stem cell populations outside conventional neurogenic regions. We previously demonstrated that brain pericytes (PCs) in both mouse and human exhibit multipotency to differentiate into various neural lineages following cerebral ischemia. Pericytes are found throughout the CNS, including cerebellum, but it remains unclear whether cerebellar PCs also form ischemia-induced multipotent stem cells (iSCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2018.0232DOI Listing
February 2019

How far will the Voyager take us?

Authors:
Victor A Levin

CNS Oncol 2019 Feb 15:CNS26. Epub 2019 Feb 15.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77005, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/cns-2018-0019DOI Listing
February 2019

Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker.

CNS Neurosci Ther 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Aims: LncRNAs play a vital role in the pathological and physiological process. This study aimed to explore the involvement of lncRNAs in cryptococcal meningitis.

Methods: Microarray was performed in cryptococcal meningitis patients, and then, GO and KEGG pathways were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cns.13109DOI Listing
February 2019
3.931 Impact Factor

Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy.

J Pharm Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

Objectives: Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13075DOI Listing
February 2019
1 Read

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

J Neurovirol 2019 Feb 14. Epub 2019 Feb 14.

Department of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-019-00723-4DOI Listing
February 2019

Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jnrp.jnrp_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337963PMC
February 2019

Is Crush Cytology of Central Nervous System Lesions Relevant in Surgical Practice Today?

J Neurosci Rural Pract 2019 Jan-Mar;10(1):34-38

Department of Neurosurgery and Pathology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Background: Intraoperative crush cytology is a useful tool for diagnosing the lesions of the central nervous system (CNS). However, because of the development of newer and better imaging techniques, it is important to evaluate if crush cytology is still relevant in neurosurgical practice.

Aims: We evaluated the crush cytology smears in a series of cases where neurosurgical intervention was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jnrp.jnrp_222_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337991PMC
February 2019

Invasive sino-orbital fungal infections in immunocompetent patients: a clinico-pathological study.

Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Orbit, Oculoplasty & Ocular Oncology, Aravind Eye Hospital, Madurai, India.

Objective: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition.

Design: Retrospective case series. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41433-019-0358-6DOI Listing
February 2019

Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%-12% of paediatric central nervous system tumours and have poor prognosis, with 2-year survival less than 30% and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated anaplastic astrocytoma treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite metastatic disease at presentation and subtotal resection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228153DOI Listing
February 2019

Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.

Acta Neuropathol Commun 2019 Feb 14;7(1):20. Epub 2019 Feb 14.

Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Monocytes/macrophages have begun to emerge as key cellular modulators of brain homeostasis and central nervous system (CNS) disease. In the healthy brain, resident microglia are the predominant macrophage cell population; however, under conditions of blood-brain barrier leakage, peripheral monocytes/macrophages can infiltrate the brain and participate in CNS disease pathogenesis. Distinguishing these two populations is often challenging, owing to a paucity of universally accepted and reliable markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-019-0665-yDOI Listing
February 2019

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
February 2019

Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin.

Antioxidants (Basel) 2019 Feb 5;8(2). Epub 2019 Feb 5.

Department of Microbiology and Immunology, and Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

Inflammation has been reported to be intimately linked to the development or worsening of several non-infectious diseases. A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antiox8020035DOI Listing
February 2019
1 Read

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

J Neuroimmunol 2019 Feb 7;330:5-11. Epub 2019 Feb 7.

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, USA.

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneuroim.2019.02.002DOI Listing
February 2019

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.

Neuropharmacology 2019 Feb 11;149:83-96. Epub 2019 Feb 11.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia. Electronic address:

Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu) have been proposed as potential therapies for various CNS disorders. These ligands bind to sites distinct from the orthosteric (or endogenous) ligand, often with improved subtype selectivity and spatio-temporal control over receptor responses. We recently revealed that mGlu allosteric agonists and positive allosteric modulators exhibit biased agonism and/or modulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2019.02.005DOI Listing
February 2019
2 Reads

TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation.

Exp Cell Res 2019 Feb 11. Epub 2019 Feb 11.

Clinical Medicine Research Center, Affiliated Hospital 2 of Nantong University, Nantong 226001, People's Republic of China; Jiangsu Key Laboratory of Neurogeneration, Nantong University, Nantong 226001, People's Republic of China; Cancer Research Center of Nantong, Tumor Hospital Affiliated to Nantong University, Nantong 226361, People's Republic of China. Electronic address:

Activating transcription factor 2 (ATF2), a member of the alkaline-leucine zipper family, is widely expressed in various tissues, and reportedly involved in inflammatory responses to various irritates, but its role in the central nervous system (CNS) remains unclear. This study aimed to investigate the expression and biological function of ATF2 in CNS inflammation. Utilizing the LPS-induced neuroinflammation model on mice, we first found ATF2 up-regulation and its co-localization with microglia in inflamed mice brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2019.02.005DOI Listing
February 2019
3.246 Impact Factor