12,861 results match your criteria CIN: Computers Informatics Nursing[Journal]
Data Brief 2018 Dec 22;21:2405-2409. Epub 2018 Nov 22.
Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Via F. Gallini 2, Aviano, Italy.
During pregnancy, the only diagnosis that may alter management is invasive cancer. Thus, the primary aim of the cytological screening and subsequent colposcopy performed during pregnancy should be the exclusion of invasive cancer, "Practice Bulletin No. 140: management of abnormal cervical cancer screening test results and cervical cancer precursors," (American College of Obstetricians and Gynecologists, 2013) . Read More
Oncol Lett 2018 Dec 28;16(6):7189-7194. Epub 2018 Sep 28.
Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200127, P.R. China.
This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. Read More
Oncol Lett 2018 Dec 26;16(6):7166-7174. Epub 2018 Sep 26.
Department of Obstetrics and Gynecology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, SK-03601 Martin, Slovakia.
Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Read More
Oncol Lett 2018 Dec 3;16(6):6887-6894. Epub 2018 Oct 3.
Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, I-35127 Padua, Italy.
Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low- and intermediate-risk classes, have favorable outcomes and display several numerical CNVs. Read More
J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.
Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.
High-risk human papillomaviruses (HPVs) have been identified as the main contributors to cervical cancer. Despite various diagnostic tools available, including the predominant Papanicolaou test (Pap test), technical limitations affect the efficiency of cervical cancer screening. The aim of this study was to evaluate the diagnostic performance of spliced HPV16 E6/E7 mRNA viral loads (VL) for grade 2 or higher cervical intraepithelial neoplasia diagnosis. Read More
Viruses 2018 Dec 8;10(12). Epub 2018 Dec 8.
Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.
Zika virus (ZIKV) is an emerging pathogen member of the family. ZIKV has spread rapidly in the Latin American region, causing hundreds of thousands of cases of ZIKV disease, as well as microcephaly in congenital infections. Detailed studies on the pattern of evolution of ZIKV strains have been extremely important to our understanding of viral survival, fitness, and evasion of the host's immune system. Read More
Comput Inform Nurs 2018 Dec 12. Epub 2018 Dec 12.
Author Affiliations: School of Nursing, University of Nevada, Las Vegas (Dr Serafica); John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu (Dr Inouye); School of Nursing, Johns Hopkins University, Baltimore, MD (Dr Lukkahatai); School of Nursing & Dental Hygiene, University of Hawaii at Manoa, Honolulu, (Dr Braginsky); and Department of Kinesiology and Exercise Science (Dr Pacheco) and School of Nursing (Dr Daub), University of Hawaii at Hilo.
The purpose of this study was to explore the barriers to and needs for using mobile health technology to assist low-income Asian American and Pacific Islander participants living in rural Hawaii in their healthcare. Three focus groups consisting of patients, family support/significant others, and providers (N = 19) were conducted to assess the unique needs of low-income Asian American and Pacific Islander patients in rural Hawaii. The electronic health literacy scale was also used among participants in the patients and family support/significant other groups. Read More
Front Immunol 2018 22;9:2729. Epub 2018 Nov 22.
Clinical Research Institute, The First People's Hospital of FoShan (Affiliated FoShan Hospital of Sun Yat-sen University), Foshan, China.
There is increasing evidence that deep sequencing-based T cell repertoire can sever as a biomarker of immune response in cancer patients; however, the characteristics of T cell repertoire including diversity and similarity, as well as its prognostic significance in patients with cervical cancer (CC) remain unknown. In this study, we applied a high throughput T cell receptor (TCR) sequencing method to characterize the T cell repertoires of peripheral blood samples from 25 CC patients, 30 cervical intraepithelial neoplasia (CIN) patients and 20 healthy women for understanding the immune alterations during the cervix carcinogenesis. In addition, we also explored the signatures of TCR repertoires in the cervical tumor tissues and paired sentinel lymph nodes from 16 CC patients and their potential value in predicting the prognosis of patients. Read More
J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.
Werner Reichardt Centre for Integrative Neuroscience, Germany.
Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well-studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Read More
Dis Markers 2018 14;2018:4826547. Epub 2018 Nov 14.
Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cervical cancer is the second leading cause of death in female genital malignancies. Persistent infection with high-risk HPV is closely related to cervical intraepithelial neoplasia (CIN). Wide-scale HPV screening has already been implemented in developed countries. Read More
Nurs Forum 2018 Dec 9. Epub 2018 Dec 9.
Center of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI.
Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. Read More
Cancer 2018 Dec 10. Epub 2018 Dec 10.
Department of Women's and Children's Health, Karolinska University Hospital and Institute, Stockholm, Sweden.
Background: The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among women with cytology negative for intraepithelial lesions or malignancy (NILM).
Methods: This was a nested case-control study including women with NILM baseline cytology participating in the Swedish cervical screening program in 2005-2007. Read More
Comput Intell Neurosci 2018 11;2018:4097561. Epub 2018 Nov 11.
School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, China.
To study the relationship between brain network and shooting performance during shooting aiming, we collected electroencephalogram (EEG) signals from 40 skilled shooters during rifle shooting and calculated the EEG functional coupling, functional brain network topology, and correlation coefficients between these EEG characteristics and shooting performance. Our result shows a significant negative correlation between shooting performance and functional coupling between the prefrontal, frontal, and temporal regions of the right brain in the Beta1 and Beta2 frequency bands. Global and local brain network topology characteristics were also significantly correlated with shooting performance. Read More
Comput Intell Neurosci 2018 5;2018:6587049. Epub 2018 Nov 5.
Carlos III University, Applied Artificial Intelligence Group, Madrid, Spain.
This work proposes a methodology that reduces the error of future estimations in commercialization based on multivariate spatial prediction techniques (cokriging) considering the products with strong associations. It is based on the algorithm to find association rules in sales of agricultural products of local markets. Results show the improvement in spatial prediction accuracy after using the best association rules. Read More
Comput Intell Neurosci 2018 8;2018:4685187. Epub 2018 Nov 8.
School of Manufacturing Science & Engineering, Sichuan University, Chengdu, China.
In the conceptual design stage, inspirational sources play an important role in designers' creative thinking. This paper proposes a retrieval method for semantic-based inspirational sources, which helps designers obtain inspirational images in the conceptual design stage of emotional design. The core principle involves solving the designer's own deficiencies in associations and limited knowledge, by bridging the "semantic gap" faced by designers when they use Kansei words for inspirational sources. Read More
Comput Intell Neurosci 2018 5;2018:1576927. Epub 2018 Nov 5.
División Académica de Informática y Sistemas, Universidad Juárez Autónoma de Tabasco, Tabasco, Mexico.
Nowadays, Machine Learning methods have proven to be highly effective on the identification of various types of diseases, in the form of predictive models. Guillain-Barré syndrome (GBS) is a potentially fatal autoimmune neurological disorder that has barely been studied with computational techniques and few predictive models have been proposed. In a previous study, single classifiers were successfully used to build a predictive model. Read More
Comput Intell Neurosci 2018 5;2018:1458962. Epub 2018 Nov 5.
College of Electronic and Information Engineering, Southwest University, 400715 Chongqing, China.
The rapid development of modern communication technology makes the identification of emitter signals more complicated. Based on Ward's clustering and probabilistic neural networks method with correlation analysis, an ensemble identification algorithm for mixed emitter signals is proposed in this paper. The algorithm mainly consists of two parts, one is the classification of signals and the other is the identification of signals. Read More
Front Immunol 2018 23;9:2742. Epub 2018 Nov 23.
Department of Gynecology, Clinical Hospital, Federal University of Parana, Curitiba, Brazil.
MBL-associated serine proteases (MASP-1, MASP-2, MASP-3, MAp-44, and MAp-19) are key factors in the activation of the lectin pathway of complement. Serum levels of these components have been associated with recurrence and poor survival of some types of cancer, such as colorectal and ovarian cancer. In this investigation, we determined the serum levels of MASP-1, MASP-2, MASP-3, MAp-44, and MAp-19 in patients with cervical cancer and cervical intraepithelial neoplasia (CIN). Read More
Comput Inform Nurs 2018 Dec 11. Epub 2018 Dec 11.
Author Affiliations: Departments of Nursing and Physiotherapy (Drs Fernández-Gutiérrez and Bas-Sarmiento), Faculty of Nursing, University of Cadiz; and Valora Prevention Ltd (Dr Poza-Méndez), Cádiz, Spain.
Health literacy is a social determinant of the basic health of populations and is especially important to enhancing and developing the empowerment of migrant populations. To evaluate the effectiveness of an mHealth intervention to improve the cognitive and social skills that enable migrants to access and use health services, we developed a quasi-experimental design to encompass a single group of enrolled immigrants (N = 93). They completed preintervention and postintervention questionnaires of the European Health Literacy Survey Questionnaire, the self-created questionnaire HL-APP-Q14 (Health Literacy App Questionnaire), and a practical simulation test. Read More
Comput Inform Nurs 2018 Dec;36(12):615
Comput Inform Nurs 2018 Dec;36(12):576-578
Institute for Informatics, Department of Medicine, Division of General Medical Sciences, Washington University School of Medicine; Goldfarb School of Nursing, Barnes Jewish College, BJC Healthcare, St Louis, MO.
Comput Inform Nurs 2018 Dec;36(12):569-575
Author Affiliations: Southern University College of Nursing and Allied Health (Dr Hebert), Baton Rouge, LA; Frances Payne Bolton School of Nursing, Case Western Reserve University (Dr Madigan), Cleveland, OH.
Comput Inform Nurs 2018 Dec 5. Epub 2018 Dec 5.
Author Affiliations: Oslo Accident and Emergency Out-Patient Clinic, Oslo (Ms Halvorsen, Dr Tomasevic, and Mr Trondsen); and SINTEF Digital (Ms Austad, Mr Ausen, and Ms Svagård) and SINTEF Technology and Society (Mr Landmark), Trondheim, Norway.
Coordination of information and resources is central to efficient ward management. Tools to aid coordination include standardized procedures and paper lists and, more recently, electronic tools such as whiteboards and mobile solutions. This study reports on the experiences and effects of designing and implementing collaboration technology, and how the use of light-weight technology has enabled redesign of traditional work processes. Read More
Eur J Intern Med 2018 Dec;58:77-83
UOC Oncoematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano; Università degli Studi di Milano, Italy.
The physiology of the immune system involves morphologic and functional changes occurring along ageing, with a decrease in immune response and an increase in autoimmune phenomena, even in the absence of overt disese. Autoimmune cytopenias, namely autoimmune hemolytic anemia (AIHA), chronic idiopathic neutropenia (CIN) and aplastic anemia (AA), show different epidemiologic predilection, but are increasingly diagnosed in the elderly, where complications and comorbidities are more frequent. A systematic review of recent literature, shows that comorbidities as well as underlying deficiencies, medications, neoplasms, and, pathophysiologic chronic organ failures, frequently challenge the differential diagnosis in this setting and should always be evaluated and excluded. Read More
J Stroke Cerebrovasc Dis 2018 Dec 6. Epub 2018 Dec 6.
UTHSC College of Graduate Health Sciences, Department of Preventive Medicine, Memphis, Tennessee.
Goal: Computed tomography angiography (CTA) is a well-tolerated, noninvasive study of the intracranial vascular circulation; however, contrast-induced nephropathy (CIN) has been reported in 5%-7% of patients undergoing CTA. Limited studies have evaluated the risks of CIN in patients undergoing CTA. Our study was designed to evaluate the prevalence and risk factors for CIN in patients with ischemic stroke who receive a CTA. Read More
Angiology 2018 Dec 9:3319718816206. Epub 2018 Dec 9.
1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
Background:: Low serum albumin, high blood urea nitrogen (BUN), and uric acid are regarded closely related to the incidence of contrast-induced nephropathy (CIN), whereas it remains unclear whether they can function as predictors of CIN onset. The objective of this systematic review and meta-analysis was to explore the association between abovementioned indicators and CIN incidence rate in patients receiving coronary angiography (CAG) and/or intervention.
Methods:: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and ScienceDirect from their inception to July 13, 2018. Read More
Infect Agent Cancer 2018 26;13:37. Epub 2018 Nov 26.
Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.
Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Read More
Anticancer Res 2018 Dec;38(12):6673-6681
Gynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, Sao Paulo, Brazil.
Aim: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.
Materials And Methods: Staining with antibody clones G175-405 for CDKN2A and OV-TL 12/30 for CK7 were evaluated and the detection of protein expressions were compared in 147 patients with CIN.
Results: Clinical follow-up of patients with CIN1 and CIN2 showed that most patients had a favorable outcome. Read More
PLoS One 2018 5;13(12):e0207714. Epub 2018 Dec 5.
Department of Women´s and Children's Health, Uppsala University, Uppsala, Sweden.
Background: About 30% of the cervical cancer cases in Sweden occur in women older than 60. The primary aim was to evaluate the acceptability of repeated self-sampling at home for HPV-testing in elderly women. The prevalence of HPV and HPV related dysplasia as well as the sensitivity of cytology was evaluated. Read More
Comput Intell Neurosci 2018 1;2018:9704672. Epub 2018 Nov 1.
School of Software, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
The KDD CUP 1999 intrusion detection dataset was introduced at the third international knowledge discovery and data mining tools competition, and it has been widely used for many studies. The attack types of KDD CUP 1999 dataset are divided into four categories: user to root (U2R), remote to local (R2L), denial of service (DoS), and Probe. We use five classes by adding the normal class. Read More
Comput Intell Neurosci 2018 1;2018:7098389. Epub 2018 Nov 1.
Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
As excessive crossed disparity is known to cause visual discomfort, this study aims to establish a classification model to discriminate excessive crossed disparity in stereoscopic viewing in combination with subjective assessment of visual discomfort. A stereo-visual evoked potentials (VEPs) experimental system was built up to obtain the VEPs evoked by stereoscopic stimulus with different disparities. Ten volunteers participated in this experiment, and forty VEP datasets in total were extracted when the viewers were under comfortable viewing conditions. Read More
Comput Intell Neurosci 2018 1;2018:6798042. Epub 2018 Nov 1.
School of Computer and Information Technology, Xinyang Normal University, Xinyang 464000, Henan, China.
Rotation Forest is an ensemble learning approach achieving better performance comparing to Bagging and Boosting through building accurate and diverse classifiers using rotated feature space. However, like other conventional classifiers, Rotation Forest does not work well on the imbalanced data which are characterized as having much less examples of one class (minority class) than the other (majority class), and the cost of misclassifying minority class examples is often much more expensive than the contrary cases. This paper proposes a novel method called Embedding Undersampling Rotation Forest (EURF) to handle this problem (1) sampling subsets from the majority class and learning a projection matrix from each subset and (2) obtaining training sets by projecting re-undersampling subsets of the original data set to new spaces defined by the matrices and constructing an individual classifier from each training set. Read More
Comput Intell Neurosci 2018 1;2018:5865168. Epub 2018 Nov 1.
College of Information Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
The artificial bee colony (ABC) algorithm has become one of the popular optimization metaheuristics and has been proven to perform better than many state-of-the-art algorithms for dealing with complex multiobjective optimization problems. However, the multiobjective artificial bee colony (MOABC) algorithm has not been integrated into the common multiobjective optimization frameworks which provide the integrated environments for understanding, reusing, implementation, and comparison of multiobjective algorithms. Therefore, a unified, flexible, configurable, and user-friendly MOABC algorithm framework is presented which combines a multiobjective ABC algorithm named RMOABC and the multiobjective evolution algorithms (MOEA) framework in this paper. Read More
Comput Intell Neurosci 2018 1;2018:5462563. Epub 2018 Nov 1.
Sustainable and Infrastructure Research and Development Center, Department of Mechanical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002, Thailand.
This paper presents a novel constraint handling technique for optimum path generation of four-bar linkages using evolutionary algorithms (EAs). Usually, the design problem is assigned to minimize the error between desired and obtained coupler curves with penalty constraints. It is found that the currently used constraint handling technique is rather inefficient. Read More
Comput Intell Neurosci 2018 1;2018:5060857. Epub 2018 Nov 1.
Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
This study proposes a multilayer hybrid deep-learning system (MHS) to automatically sort waste disposed of by individuals in the urban public area. This system deploys a high-resolution camera to capture waste image and sensors to detect other useful feature information. The MHS uses a CNN-based algorithm to extract image features and a multilayer perceptrons (MLP) method to consolidate image features and other feature information to classify wastes as recyclable or the others. Read More
Comput Intell Neurosci 2018 1;2018:4759405. Epub 2018 Nov 1.
Department of Computer Science, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Web service composition is a method of developing a new web service from an existing one based on business goals. Web services selected for composition should provide accurate operational results and reliable applications. However, most alternative service providers have not yet fulfilled users' needs in terms of services and processes. Read More
Comput Intell Neurosci 2018 1;2018:1853517. Epub 2018 Nov 1.
Department of Communication and Information Engineering, Shanghai Technical Institute of Electronics & Information, Shanghai 201411, China.
Multiple kernel learning (MKL) as an approach to automated kernel selection plays an important role in machine learning. Some learning theories have been built to analyze the generalization of multiple kernel learning. However, less work has been studied on multiple kernel learning in the framework of semisupervised learning. Read More
Comput Intell Neurosci 2018 1;2018:1275290. Epub 2018 Nov 1.
Mathematical Science Center, University of Yamanashi, Takeda 4-3-11, Kofu, Yamanashi 400-8511, Japan.
A twin-multistate quaternion Hopfield neural network (TMQHNN) is a multistate Hopfield model and can store multilevel information, such as image data. Storage capacity is an important problem of Hopfield neural networks. Jankowski et al. Read More
Biochem Biophys Res Commun 2018 Dec 1. Epub 2018 Dec 1.
Department of Life Science, College of Natural Sciences, Chung-Ang University, 06974, Seoul, Republic of Korea. Electronic address:
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most lethal cancer worldwide. Although gene mutations associated with HCC development have been intensively studied, how epigenetic factors specifically modulate the functional properties of HCC by regulating target gene expression is unclear. Here we demonstrated the overexpression of KDM3B in liver tissue of HCC patients using public RNA-seq data. Read More
Cell Cycle 2018 4;17(23):2622-2636. Epub 2018 Dec 4.
a Cancer Biology Program , Philadelphia , PA , USA.
We characterized a panel of cancer cells and found that they exhibited chromosome instability (CIN) that was associated with high frequencies of aberrant kinetochore:microtubule attachments. Failure to resolve these defective attachments before anaphase onset can lead to missegregation of chromosomes. Aurora B kinase is concentrated at the inner centromere where it contributes to multiple kinetochore functions, one of which is in error-correction. Read More
Comput Intell Neurosci 2018 28;2018:9593682. Epub 2018 Oct 28.
Institute of Intelligent Control and Robotics, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China.
Classification of motor imagery (MI) electroencephalogram (EEG) plays a vital role in brain-computer interface (BCI) systems. Recent research has shown that nonlinear classification algorithms perform better than their linear counterparts, but most of them cannot extract sufficient significant information which leads to a less efficient classification. In this paper, we propose a novel approach called FDDL-ELM, which combines the discriminative power of extreme learning machine (ELM) with the reconstruction capability of sparse representation. Read More
Comput Intell Neurosci 2018 29;2018:1365747. Epub 2018 Oct 29.
China University of Mining and Technology, Xuzhou 221116, China.
Compressed sensing (CS) is an important research area of signal sampling and compression, and the essence of signal recovery in CS is an optimization problem of solving the underdetermined system of equations. Greedy pursuit algorithms are widely used to solve this problem. They have low computational complexity; however, their recovery performance is limited. Read More
Genes Dev 2018 12;32(23-24):1459-1460
Department of Molecular Genetics, University of Kaiserslautern, Kaiserslautern 67663, Germany.
Chromosomal instability (CIN) generates continuously novel aneuploid genomes-unbalanced chromosome combinations that differ from the haploid chromosome set and its multiples. On one hand, this causes problems for cells, as high CIN and aneuploidy impair cellular proliferation by inducing multiple cellular stresses. At the same time, some genomes might provide an advantage under suboptimal conditions. Read More
BMC Cancer 2018 Dec 3;18(1):1197. Epub 2018 Dec 3.
MVZ CytoMol, Berner Str. 76, Frankfurt, Germany.
Background: A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs.
Results: In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. Read More
Ann Surg Oncol 2018 Nov 29. Epub 2018 Nov 29.
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, USA.
Background: Current guidelines recommend radical cholecystectomy with regional lymphadenectomy (RC-RL) for patients with T1b gallbladder cancer (GBC). However, the extent to which these guidelines are followed is unclear. This study aimed to evaluate current surgical practices for T1b GBC and their implications for overall management strategies and associated outcomes. Read More
J Neural Transm (Vienna) 2018 Nov 29. Epub 2018 Nov 29.
Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstr.14, 72076, Tübingen, Germany.
Attention biases towards threat signals have been linked to the etiology and symptomatology of social anxiety disorder (SAD). Dysfunction of the dorsolateral prefrontal cortex (dlPFC) may contribute to attention biases in anxious individuals. The aim of this study was to investigate the feasibility of near-infrared spectroscopy (NIRS) neurofeedback (NF) training-targeting the dlPFC-and its effects on threat-related attention biases of individuals with SAD. Read More
Cancer Res 2018 Nov 29. Epub 2018 Nov 29.
Department of Biochemistry and Molecular, Beijing Cancer Hospital.
The oncogenic phosphatase PRL-3 is highly expressed in metastatic colorectal cancer (CRC) but not in non-metastatic CRC or non-CRC metastatic cancers. Although the pro-invasive capacity of PRL-3 has been validated in multiple types of cancer, its impact on CRC progression and the underlying mechanisms remain poorly understood. Here we report that overexpressed PRL-3 stimulates G2/M arrest, chromosomal instability (CIN), self-renewal, and growth of CRC cells in xenograft models, while CRC cell proliferation is decreased. Read More
BMC Cancer 2018 Nov 29;18(1):1182. Epub 2018 Nov 29.
Department of Gynecology, Guangdong Women and Children Hospital, 521 Xing Nan Road, Guangzhou, 511400, Guangdong Province, China.
Background: To explore the diagnostic value of FAM19A4 methylation in high-risk human papilloma virus (hrHPV)-positive cervical samples from Chinese women for estimating cervical cancer or its precancerous lesions.
Methods: Cervical samples from 215 women infected with high-risk HPV were collected by smear testing. We purposely chose 61 patients with cervical cancer, 57 with high-grade squamous intraepithelial lesions (HSIL), 31 with low-grade squamous intraepithelial lesions (LSIL), and 66 without cervical intraepithelial neoplasia (CIN) after histological confirmation. Read More
Asian Pac J Cancer Prev 2018 Nov 29;19(11):3071-3075. Epub 2018 Nov 29.
Preventative Gynecology Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Email:
Background: Anal cancer is uncommon. Although uncommon, the incidence of anal cancer has increased among the general population of the United States and other countries over the past 30 years. We evaluated anal cytology in women with the history of abnormal pap smear, cervical intraepithelial neoplasia, cervical cancer and high risk HPV for anogenital dysplasia. Read More
Braz J Med Biol Res 2018 Nov 23;52(1):e7517. Epub 2018 Nov 23.
Department of Obstetrics and Gynecology, Institution Zaozhuang Municipal Hospital, Zaozhuang, Shandong Province, China.
The aim of this study was to explore the value of different combination schemes of liquid-based cytology (LBC) and high-risk human papilloma virus (HPV) test in the screening of high-grade (≥CIN 2) cervical lesions. From 5727 women who had undergone examinations with LBC and high-risk HPV test, 1884 patients with positive results of either or both LBC and HPV test were included in this study and underwent cervical biopsy. Based on the pathological examination results, comparisons of the assessment indicators of all diagnostic tests were made, and the application values of LBC and high-risk HPV test and different combination schemes of the two in the screening of high-grade (≥CIN II) cervical lesions were estimated. Read More