496 results match your criteria CEN case reports[Journal]


Bevacizumab-associated glomerular microangiopathy that occurred after postoperative chemotherapy for ovarian cancer.

CEN Case Rep 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, Japan.

Bevacizumab is a monoclonal antibody against vascular endothelial growth factor (VEGF) that is used to treat patients with various cancers. However, it is known to be associated with adverse events, such as hypertension and proteinuria. The histology of bevacizumab-induced nephropathy is known as thrombotic microangiopathy or minimal change nephrotic syndrome. Read More

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http://dx.doi.org/10.1007/s13730-020-00504-7DOI Listing

A different clinical manifestation in a Japanese family with autosomal dominant distal renal tubular acidosis caused by SLC4A1 mutation.

CEN Case Rep 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Mutations in SLC4A1, encoding the chloride-bicarbonate exchanger known as anion exchanger 1, have been reported as the sole genetic cause of autosomal dominant distal renal tubular acidosis (dRTA). This disorder is extremely rare and most patients show no clinical symptoms during childhood. Here, we report a case of an infant with early-onset autosomal dominant dRTA caused by SLC4A1 mutation p. Read More

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http://dx.doi.org/10.1007/s13730-020-00500-xDOI Listing

Hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis.

CEN Case Rep 2020 Jul 6. Epub 2020 Jul 6.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan.

Hypercalcemia is usually secondary to one etiology, although two coexisting etiologies can rarely cause hypercalcemia. Here, we report a 47-year-old woman with hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis. Primary hyperparathyroidism is the most common cause of hypercalcemia. Read More

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http://dx.doi.org/10.1007/s13730-020-00509-2DOI Listing

A case of acute renal failure with multiple origins of the renal injury.

CEN Case Rep 2020 Jul 4. Epub 2020 Jul 4.

Nephrology and Dialysis Unit, Belcolle Hospital, Via Sammartinese, Snc, 01100, Viterbo, Italy.

Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). Patients with AKI must be evaluated promptly to determine cause. Different disorders can BE associated with AKI, and biopsy is the most accurate instrument for diagnosis of different types of diseases. Read More

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http://dx.doi.org/10.1007/s13730-020-00505-6DOI Listing

A case with somatic and germline mosaicism in COL4A5 detected by multiplex ligation-dependent probe amplification in X-linked Alport syndrome.

CEN Case Rep 2020 Jul 4. Epub 2020 Jul 4.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

X-linked Alport syndrome (XLAS) is a progressive hereditary kidney disease caused by mutations in the COL4A5 gene encoding the type IV collagen α5 chain. To date, 11 cases having somatic mosaic variants in COL4A5 have been reported; however, all of them involved single-nucleotide variations (SNVs). Here, we report a female XLAS patient with somatic mosaicism identified by copy number variation (CNV) in COL4A5. Read More

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http://dx.doi.org/10.1007/s13730-020-00503-8DOI Listing

Rapid progression to end-stage renal disease in a child with IgA-dominant infection-related glomerulonephritis associated with parvovirus B19.

CEN Case Rep 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Parvovirus B19 (PVB19) has been known to cause acute glomerulonephritis and nephrotic syndrome with various renal histologic patterns, such as endocapillary glomerulonephritis and collapsing glomerulopathy. Remission is achieved spontaneously or by treatment with steroid and/or immunosuppressants in most patients, except those with sickle cell anemia or two APOL1 risk alleles. In this study, we report the case of a previously healthy 5-year-old boy with infection-related glomerulonephritis (IRGN) associated with PVB19 that progressed to end-stage renal disease (ESRD). Read More

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http://dx.doi.org/10.1007/s13730-020-00501-wDOI Listing

Ultrasound appearance of the lymphomatous infiltration of the kidney.

CEN Case Rep 2020 Jun 30. Epub 2020 Jun 30.

Division of Nephrology, Medical College of Wisconsin, Milwaukee, Room A 7633, 8701 W Watertown Plank Rd, Wauwatosa, WI, 53226, USA.

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http://dx.doi.org/10.1007/s13730-020-00502-9DOI Listing

Poststreptococcal acute glomerulonephritis can be a risk factor for accelerating kidney dysfunction in Alport syndrome: a case experience.

CEN Case Rep 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo, Kobe, Hyogo, 650-0017, Japan.

Alport syndrome (AS) is a progressive kidney disease. Male cases with X-linked AS (XLAS) are reported to develop end-stage kidney disease (ESKD) at the age of around 20-30 years. One risk factor for developing ESKD at a young age is a genotype of having truncating variants in the COL4A5 gene. Read More

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http://dx.doi.org/10.1007/s13730-020-00498-2DOI Listing

A rare case of peritonitis in a young woman on peritoneal dialysis.

CEN Case Rep 2020 Jun 24. Epub 2020 Jun 24.

Department of Nephrology, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

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http://dx.doi.org/10.1007/s13730-020-00499-1DOI Listing

Secondary bladder amyloidosis due to Crohn's disease: a case report and literature review.

CEN Case Rep 2020 Jun 22. Epub 2020 Jun 22.

Department of Urology, S. Orsola-Malpighi University Hospital, Via P. Palagi 9, 40138, Bologna, Italy.

The presence of amyloid deposits in bladder walls is a rare histological finding. It can be linked to primary (limited to bladder) or secondary (systemic, associated with chronic inflammatory disorders) amyloidosis. Secondary bladder involvement is very uncommon; it usually presents with gross hematuria, which is challenging to manage, due to frail bladder mucosa and/or necrosis. Read More

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http://dx.doi.org/10.1007/s13730-020-00497-3DOI Listing

Fatal SARS-CoV-2 infection in a renal transplant recipient.

CEN Case Rep 2020 Jun 20. Epub 2020 Jun 20.

Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) caused a pandemic that first discovered in Wuhan, China. While 10% of the patients have asymptomatic infection, 15-20% have lung involvement, 5-10% have multiple organ failure, and macrophage activation syndrome. Chronic respiratory diseases, diabetes mellitus, hypertension, and cancer are risk factors for mortality. Read More

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http://dx.doi.org/10.1007/s13730-020-00496-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305930PMC

Low-density lipoprotein apheresis for PLA2R-related membranous glomerulonephritis accompanied by IgG4-related tubulointerstitial nephritis.

CEN Case Rep 2020 Jun 16. Epub 2020 Jun 16.

Department of Medicine, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa, Tokyo, 116-8567, Japan.

IgG4-related disease preferentially involves the kidney by tubulointerstitial nephritis with IgG4-positive plasma cell filtration and/or membranous glomerulonephritis. We reported the case of a 68-year-old man with IgG4-related tubulointerstitial nephritis combined with antiphospholipase A2 receptor (PLA2R)-related membranous glomerulonephritis, in which distinguishing between idiopathic PLA2R-related and IgG4-related secondary membranous glomerulonephritis was difficult. We diagnosed him as having IgG4-related disease, based on a serum IgG4 level of 170 mg/dL and the presence of IgG4-related parotiditis. Read More

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http://dx.doi.org/10.1007/s13730-020-00494-6DOI Listing

The first case of COVID-19 pneumonia in a hemodialysis patient in Japan.

CEN Case Rep 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

On 31 December 2019, cases of pneumonia whose cause was later identified as SARS-CoV-2 were detected in Wuhan City, Hubei Province of China, and now COVID-19 has spread worldwide. On March 1, 2020, a 69-year-old Japanese man who had been on hemodialysis for 3 years was diagnosed as having COVID-19 pneumonia and hospitalized at our Medical Center. Pulmonary CT revealed bilateral multiple consolidation with bilateral pleural effusion. Read More

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http://dx.doi.org/10.1007/s13730-020-00495-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300373PMC

The case of Kawasaki disease after rituximab infusion triggered by human anti-chimeric antibodies.

CEN Case Rep 2020 Jun 13. Epub 2020 Jun 13.

Department of Pediatric Nephrology, Shizuoka Children's Hospital, Urushiyama 860, Aoi-ku, Shizuoka, 420-8660, Japan.

Rituximab (RTX) is an effective treatment for refractory nephrotic syndrome (NS), but may produce human anti-chimeric antibodies (HACA) which can cause severe infusion reaction or rituximab-induced serum sickness (RISS). RISS presents with a fever, rash, and arthralgia, which typically occurs 7-21 days after RTX infusion. On the other hand, Kawasaki disease (KD) also presents with fever and rash. Read More

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http://dx.doi.org/10.1007/s13730-020-00492-8DOI Listing

Secondary renal amyloidosis associated with asbestos-related pleuropulmonary diseases.

CEN Case Rep 2020 Jun 13. Epub 2020 Jun 13.

Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonan-ku, Fukuoka, 814-0180, Japan.

Here, we present a 67-year-old Japanese man who developed insidious-onset nephrotic syndrome. He had a history of occupational asbestos exposure for about 8 years during his 30s, and was found to have pleural effusion 3 years before his present illness. At that time, repeated cytology testing of his pleural effusion found no malignant cells, and pleural biopsy found fibrous pleuritis without evidence of malignant mesothelioma. Read More

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http://dx.doi.org/10.1007/s13730-020-00493-7DOI Listing

A rare case of nephrotic syndrome associated with Dent's disease: a case report.

CEN Case Rep 2020 Jun 12. Epub 2020 Jun 12.

Department of Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba-shi, Chiba, 260-8677, Japan.

Dent's disease is a rare X-linked condition caused by a mutation in CLCN5 and OCRL gene, which impair the megalin-cubilin receptor-mediated endocytosis in kidney's proximal tubules. Thus, it may manifest as nephrotic-range low-molecular-weight proteinuria (LMWP). On the other hand, glomerular proteinuria, hypoalbuminemia, and edema formation are the key features of nephrotic syndrome that rarely found in Dent's disease. Read More

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http://dx.doi.org/10.1007/s13730-020-00491-9DOI Listing

Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency.

CEN Case Rep 2020 Jun 6. Epub 2020 Jun 6.

Department of Nephrology, Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8102, Japan.

Bartter syndrome and Gitelman syndrome (GS) are autosomal recessive disorders usually caused by homozygous or compound heterozygous mutations in causative genes. In some patients, these two syndromes cannot be discriminated based on clinical features or mutation type; thus, a single disease concept, salt-losing tubulopathies (SLTs), has been used instead. Despite the existence of several SLT causative genes, cases of digenic heterozygous mutations in two different genes are extremely rare. Read More

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http://dx.doi.org/10.1007/s13730-020-00489-3DOI Listing

Candida albicans and Staphylococcus lugdunensis superinfection of liver cysts in a patient with autosomal dominant polycystic kidney disease under prednisolone treatment.

CEN Case Rep 2020 May 21. Epub 2020 May 21.

Department of Nephrology, Nephrology Center, Toranomon Hospital Kajigaya, Takatsu-ku Kajigaya 1-3-1, Kawasaki City, Kanagawa, 213-8587, Japan.

We report a case of superinfection of liver cysts caused by Candida albicans and Staphylococcus lugdunensis in a patient with autosomal dominant polycystic kidney disease. A 69-year-old man with chief complaints of headache and blurred vision was admitted to the former institution for the evaluation of suspected temporal arteritis. He was prescribed oral prednisolone (55 mg/day) as a preemptive treatment; however, he became febrile and presented with bilateral flank pain during prednisolone tapering. Read More

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http://dx.doi.org/10.1007/s13730-020-00488-4DOI Listing

Comparison of clinical outcomes following early rehabilitation in 3 cases of nephrotic syndrome with different treatment courses.

CEN Case Rep 2020 May 10. Epub 2020 May 10.

Department of Nephrology, Shiga University of Medical Science, Otsu, Shiga, Japan.

There have been few published reports regarding rehabilitation for nephrotic syndrome. We compared the clinical outcomes of three cases of nephrotic syndrome with different treatment courses during 5 weeks of early rehabilitation.We report on three cases of nephrotic syndrome. Read More

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http://dx.doi.org/10.1007/s13730-020-00486-6DOI Listing

A case of long-term dasatinib-induced proteinuria and glomerular injury.

CEN Case Rep 2020 May 9. Epub 2020 May 9.

Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma, 371-8511, Japan.

A 52-year-old woman was diagnosed with chronic myeloid leukemia. Treatment with dasatinib, a second-generation Bcr-Abl tyrosine kinase inhibitor, was initiated, and complete cytogenetic remission was achieved. Two years later, proteinuria occurred, and the urinary protein level increased gradually in the next 3 years. Read More

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http://dx.doi.org/10.1007/s13730-020-00484-8DOI Listing

A case report of progressive multifocal leukoencephalopathy during steroid treatment for ANCA-associated renal vasculitis.

CEN Case Rep 2020 May 9. Epub 2020 May 9.

Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Case Report: an 80-year-old woman presented with rapidly progressive glomerulonephritis and was admitted to our hospital. Myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA) was positive. We diagnosed ANCA-associated renal vasculitis (ANCA-RV). Read More

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http://dx.doi.org/10.1007/s13730-020-00482-wDOI Listing

Rapidly progressive glomerulonephritis caused by tegafur/gimeracil/oteracil resulted in diabetes nephropathy, in a patient with minor risk of diabetes nephropathy: a case report.

CEN Case Rep 2020 May 7. Epub 2020 May 7.

Nephrology Center and Department of Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 212-0015, Japan.

A 79-year-old Japanese male with a history of type 2 diabetes mellitus (T2DM) for 16 years was admitted to evaluate possible renal disease. The T2DM was well controlled in this patient using nutrition therapy without the need for any diabetes medication, and both diabetes retinopathy and proteinuria were negative. At the age of 78 advanced colorectal cancer (stage IIIa) was diagnosed and laparoscopic-assisted colectomy was performed. Read More

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http://dx.doi.org/10.1007/s13730-020-00485-7DOI Listing

Recurrent macroscopic hematuria in a pediatric patient: is it early to diagnose as having type I hereditary C2 deficiency?

CEN Case Rep 2020 May 5. Epub 2020 May 5.

Department of Pediatric Rheumatology, Faculty of Medicine, Cukurova University, Saricam, Adana, 01331, Turkey.

Hereditary C2 deficiency is the most common early complement deficiency and characterized by recurrent infections and autoimmunity despite most patients are also asymptomatic. Type I hereditary C2 deficiency is caused by a heterozygous deletion in C2 gene resulting in early stop codon and lack of C2 production. Clinical spectrum may vary and pure nephrological involvement without the presence of recurrent infections is scarce in hereditary C2 deficiency. Read More

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http://dx.doi.org/10.1007/s13730-020-00487-5DOI Listing

Characteristic Renal Histology of a 81-Year-Old Patient with a 30-Year History of Diabetes Mellitus: A Case Report.

CEN Case Rep 2020 May 2. Epub 2020 May 2.

Nephrology Center, Toranomon Hospital, 1-3-1, Takatsu, KajigayaKawasaki, Kanagawa, 212-0015, Japan.

A renal histology of an 81-year-old man with a 30-year history of diabetes mellitus (DM), as well as diabetic retinopathy and neuropathy, was examined. The patient's blood pressure was controlled within the normal range (less than 140/75 mmHg) using antihypertensive agents including angiotensin receptor blocker. Edematous management was achieved by a strict salt diet (less than 6 g/per day). Read More

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http://dx.doi.org/10.1007/s13730-020-00483-9DOI Listing

Effective improvement of minimal change nephrotic syndrome with uncontrollable high low-density lipoprotein cholesterol level using evolocumab accompanied by the development of acute pancreatitis.

CEN Case Rep 2020 May 1. Epub 2020 May 1.

Department of Nephrology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

Nephrotic syndrome is sometimes refractory; however, it is rarely accompanied by acute pancreatitis. A 47-year-old Japanese woman complaining of limb edema was diagnosed with nephrotic syndrome. Blood and urine examinations suggested minimal change nephrotic syndrome (MCNS), and pulse intravenous methylprednisolone was administered, followed by oral prednisolone. Read More

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http://dx.doi.org/10.1007/s13730-020-00481-xDOI Listing

A case of proliferative glomerulonephritis with immunoglobulin A1-lambda deposits successfully treated by chemotherapy.

CEN Case Rep 2020 Apr 30. Epub 2020 Apr 30.

Division of Nephrology, Department of Internal Medicine, Toyonaka Municipal Hospital, 4-14-1, Shibahara-cho, Toyonaka, Osaka, 560-8565, Japan.

A 74-year-old man presented with nephrotic syndrome and kidney insufficiency. Laboratory tests revealed monoclonal gammopathy of immunoglobulin A-lambda. Renal biopsy revealed diffuse mesangial proliferation and double-contoured basement membranes. Read More

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http://dx.doi.org/10.1007/s13730-020-00480-yDOI Listing

Correction to: Dietary potassium restriction attenuates urinary sodium wasting in the generalized form of pseudohypoaldosteronism type 1.

CEN Case Rep 2020 Aug;9(3):294

Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center, Mutsukawa, 2‑138‑4, Minami‑ku, Yokohama, 232‑8555, Japan.

In the Original publication of the article, there are two minor errors in Fig. 2 and these include one missing arrow in Fig. 2d and appears as an incorrectly drawn solid lines as dashed line in Fig. Read More

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http://dx.doi.org/10.1007/s13730-020-00477-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320077PMC

Tocilizumab-induced immunocomplex glomerulonephritis: a report of two cases.

CEN Case Rep 2020 Apr 27. Epub 2020 Apr 27.

Department of Nephrology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

We report here two cases of membranoproliferative glomerulonephritis that developed during treatment of rheumatoid arthritis with tocilizumab. In both cases, the initial findings were proteinuria and haematuria, followed by development of bilateral lower leg oedema. One of the patients was weakly positive for anti-nuclear antibody; both had hypocomplementaemia. Read More

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http://dx.doi.org/10.1007/s13730-020-00478-6DOI Listing

Coexistence of emphysematous cystitis and bilateral emphysematous pyelonephritis: a case report and review of the literature.

CEN Case Rep 2020 Apr 23. Epub 2020 Apr 23.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico, Mexico.

Emphysematous pyelonephritis (EPN) is a necrotizing infection characterized by the production of gas in the renal parenchyma, collecting system or perirenal tissue. Meanwhile, emphysematous cystitis (EC) is a clinical entity characterized by the presence of gas inside and around the bladder wall. Interestingly, although both diseases are common in patients with diabetes mellitus, these are rarely combined. Read More

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http://dx.doi.org/10.1007/s13730-020-00479-5DOI Listing

Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient.

CEN Case Rep 2020 Apr 22. Epub 2020 Apr 22.

Department of Nephrology, Saiyu Soka Hospital, 1-7-22 Matsubara, Soka, Saitama, Japan.

Recently, postmortem imaging is sometimes used as an alternative to conventional autopsy. However, there are few case reports of postmortem imaging of dialysis patients. Here, we report a fatal case of gas gangrene involving a 76-year-old man who underwent dialysis. Read More

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http://dx.doi.org/10.1007/s13730-020-00456-yDOI Listing

Refractory secondary thrombotic microangiopathy with kidney injury associated with systemic lupus erythematosus in a pediatric patient.

CEN Case Rep 2020 Apr 18. Epub 2020 Apr 18.

Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan.

Thrombotic microangiopathy (TMA) is generally diagnosed through clinical features characterized as microangiopathic hemolytic anemia, thrombocytopenia, and multiple organ injury, as well as by pathological findings such as vascular damage and endothelial cell injury. Rheumatic and autoimmune diseases could be accompanied by secondary TMA; in fact, systemic lupus erythematosus (SLE) is a common disease associated with secondary TMA, and SLE complicated with TMA has been reported to have a poor prognosis. Although TMA occurs rarely in pediatric SLE patients, it often leads to severe clinical conditions. Read More

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http://dx.doi.org/10.1007/s13730-020-00475-9DOI Listing

In response to the comment on "Sequential nonarteritic anterior ischemic optic neuropathy in patient on chronic hemodialysis".

CEN Case Rep 2020 Apr 13. Epub 2020 Apr 13.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, 801 Eglinton Ave West, Suite 301, Toronto, ON, M5N 1E3, Canada.

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http://dx.doi.org/10.1007/s13730-020-00476-8DOI Listing

Nintedanib-induced glomerular microangiopathy: a case report.

CEN Case Rep 2020 Apr 11. Epub 2020 Apr 11.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan.

Nintedanib, a triple tyrosine kinase inhibitor of vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has been used in idiopathic pulmonary fibrosis and adenocarcinoma in advanced non-small cell lung cancer. Although vascular endothelial growth factor inhibitors have been reported to cause endothelial injury and glomerular microangiopathy, nintedanib-induced glomerular microangiopathy has not been reported. A 68-year-old man with a history of primary aldosteronism, idiopathic pulmonary fibrosis, and pleomorphic carcinoma of the lung developed proteinuria and leg edema after nintedanib initiation. Read More

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http://dx.doi.org/10.1007/s13730-020-00474-wDOI Listing

Ask-Upmark kidney in a girl with neurofibromatosis type 1.

CEN Case Rep 2020 Aug 10;9(3):285-288. Epub 2020 Apr 10.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Ask-Upmark kidney (AUK) is a scarred segment of the kidney, characterized by formation of primitive tubular and glomerular structures, and sporadically diagnosed as a cause of hypertension (HTN). A 6-year-old girl with neurofibromatosis type 1 (NF1) and moyamoya syndrome had severe HTN. Based on past history, she had HTN at the age of 1. Read More

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http://dx.doi.org/10.1007/s13730-020-00470-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320095PMC

Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature.

CEN Case Rep 2020 Aug 10;9(3):278-284. Epub 2020 Apr 10.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 8128582, Japan.

A 71-year-old woman was hospitalized for the treatment of fatigue, fever, and cough. On admission, she showed increased serum inflammation markers, severe anemia, pulmonary hemorrhage, and advanced acute kidney injury requiring hemodialysis. Her serum anti-glomerular basement membrane (GBM) antibody titer was found to be extremely high on the 7th hospital day. Read More

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http://dx.doi.org/10.1007/s13730-020-00473-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320086PMC

The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD.

CEN Case Rep 2020 Aug 9;9(3):271-277. Epub 2020 Apr 9.

Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, 827 Linden Avenue, 2nd floor, Baltimore, MD, 21201, USA.

Although diabetes remains the number one cause of renal failure nationwide, spontaneous hypoglycemia in patients with CKD has also been described in the absence of exogenous insulin or any other diabetes treatment. Decreased renal gluconeogenesis and impaired renal insulin clearance are underlying mechanisms of hypoglycemia in individuals with ESRD. Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release. Read More

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http://dx.doi.org/10.1007/s13730-020-00471-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320103PMC

Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review.

CEN Case Rep 2020 Aug 8;9(3):266-270. Epub 2020 Apr 8.

Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, 520-2192, Japan.

A 43-year-old male patient on maintenance hemodialysis had an enhanced computed tomography scan examination with iohexol for the first time 10 min before regular hemodialysis therapy. At the start of hemodialysis, no symptoms were observed, and the platelet count was 148,000/μl. Approximately 1 h after starting hemodialysis, dyspnea and chest discomfort appeared. Read More

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http://dx.doi.org/10.1007/s13730-020-00468-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320079PMC

Bardet-Biedl syndrome in two unrelated patients with identical compound heterozygous SCLT1 mutations.

CEN Case Rep 2020 Aug 6;9(3):260-265. Epub 2020 Apr 6.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Bardet-Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy characterized by retinitis pigmentosa (RP), truncal obesity, cognitive impairment, hypogonadism in men, polydactyly, and renal abnormalities with severe renal dysfunction. Twenty-two causative genes have already been reported for this disorder. In this study, we identified two unrelated Japanese patients with clinical diagnoses of BBS associated with compound heterozygous SCLT1 mutation. Read More

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http://dx.doi.org/10.1007/s13730-020-00472-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320120PMC

Aortic dissection or spontaneous renal artery dissection, a rare diagnosis?

CEN Case Rep 2020 Aug 3;9(3):257-259. Epub 2020 Apr 3.

Department of Emergency Medicine, Health Science University Antalya Training and Research Hospital, Kazım Karabekir Street, Muratpaşa, 07100, Antalya, Turkey.

Spontaneous renal artery dissection (SRAD) is a rare entity causing muscle spasm due to acute low back pain, back pain, or flank pain symptoms or misleading clinical diagnosis such as renal colic. A 25-year-old Syrian male refugee presented to the emergency department with sudden onset of left-sided flank pain in the evening. Physical examination results were normal except left-sided costovertebral angle sensitivity. Read More

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http://dx.doi.org/10.1007/s13730-020-00469-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320080PMC

Localized solitary left renal vein thrombus complicating nutcracker syndrome: a case report and review of the literature.

CEN Case Rep 2020 Aug 3;9(3):252-256. Epub 2020 Apr 3.

Department of Cardiology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.

Nutcracker syndrome (NCS) refers to compression of the left renal vein (LRV) between the abdominal aorta and the superior mesenteric artery (SMA). The clinical presentation of NCS includes hematuria, abdominal and left flank pain, gonadal varices, and varicocele formation. Theoretically, thrombosis can occur in the LRV in patients with NCS. Read More

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http://dx.doi.org/10.1007/s13730-020-00467-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320084PMC

Prophylactic amoxicillin for the prevention of meningococcal infection in infants with atypical hemolytic uremic syndrome under treatment with eculizumab: a report of two cases.

CEN Case Rep 2020 Aug 2;9(3):247-251. Epub 2020 Apr 2.

Department of Nephrology, Aichi Children's Health and Medical Center, 7-426 Morioka-cho, Obu, Aichi, 474-8710, Japan.

Eculizumab, a humanized monoclonal antibody to complement C5, is a therapeutic drug for atypical hemolytic-uremic syndrome (aHUS) that inhibits the terminal pathway of complement. Patients on eculizumab therapy may become more susceptible to infection with capsule-forming bacteria, including meningococci. Therefore, meningococcal vaccination is required for patients who are on eculizumab therapy. Read More

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http://dx.doi.org/10.1007/s13730-020-00465-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320125PMC

Hypersensitivity reactions to bicarbonate dialysate containing acetate: a case report with literature review.

CEN Case Rep 2020 Aug 27;9(3):243-246. Epub 2020 Mar 27.

Department of Kidney Disease, Kawashima Hospital, 1-39 Kitasakoichiban-cho, Tokushima, 770-0011, Japan.

Although hemodialysis-hypersensitivity reactions have various causes, only a few cases of hypersensitivity to acetate dialysate accompanied by fever have been reported. We present the case of a 69-year-old hemodialysis patient who was admitted due to fever after dialysis. He had undergone online hemodiafiltration using acetate-free citrate-containing dialysate. Read More

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http://dx.doi.org/10.1007/s13730-020-00466-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320085PMC

Clinical course and pathological findings of two late-onset Fabry hemizygous patients including mulberry cell counts after enzyme replacement therapy.

CEN Case Rep 2020 Aug 18;9(3):237-242. Epub 2020 Mar 18.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Inashiki, Ibaraki, 300-0395, Japan.

Fabry disease is an X-linked inherited lysosomal storage disorder caused by a deficiency of α-galactosidase A activity, resulting in the intracellular accumulation of globotriaosylceramide and related glycosphingolipids. The phenotypes of Fabry disease in both males and females are grouped into two categories: the classical type and the late-onset type. The classical type shows general symptoms including angiokeratoma(s), acroparesthesia, hypohidrosis, corneal opacity, and gastrointestinal symptoms from an early age. Read More

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http://dx.doi.org/10.1007/s13730-020-00463-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320132PMC

Isolated nephrocalcinosis due to compound heterozygous mutations in renal outer medullary potassium channel.

CEN Case Rep 2020 Aug 17;9(3):232-236. Epub 2020 Mar 17.

Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Identification of a monogenic etiology is possible in a proportion of patients with childhood-onset nephrolithiasis or nephrocalcinosis. Bartter syndrome (BS), a hereditary tubulopathy characterized by polyuria, hypokalemic alkalosis and growth retardation that rarely presents with isolated nephrocalcinosis. Patients with defect in renal outer medullary potassium channel, encoded by the KCNJ1 gene causing BS type 2, typically present during the neonatal period. Read More

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http://dx.doi.org/10.1007/s13730-020-00464-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320131PMC

Incidental detection of Corynebacterium jeikeium endocarditis via regular blood examination in an afebrile hemodialysis patient.

CEN Case Rep 2020 Aug 16;9(3):220-224. Epub 2020 Mar 16.

Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan.

Herein, we describe a rare case of Corynebacterium jeikeium endocarditis that silently progressed in a 65-year-old man undergoing hemodialysis. Because routine monthly blood examination revealed high C-reactive protein levels, blood cultures were collected, although he had no symptom and was afebrile. After 2 days, a Gram-positive rod was detected in one set of the blood culture. Read More

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http://dx.doi.org/10.1007/s13730-020-00458-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320099PMC

Induction of hemodialysis with an arteriovenous fistula in a patient with hemophilia A.

CEN Case Rep 2020 Aug 16;9(3):225-231. Epub 2020 Mar 16.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, Japan.

An 88-year-old man with congenital hemophilia A developed end-stage renal disease due to microscopic polyangiitis. He was at risk for catheter-related infection because he was taking immunosuppressive agents for the treatment of polyangiitis. He was also unable to manipulate the peritoneal dialysis device. Read More

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http://dx.doi.org/10.1007/s13730-020-00461-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320112PMC

Pembrolizumab-associated nephrotic syndrome recovered from transient hemodialysis in a patient with lung cancer.

CEN Case Rep 2020 Aug 13;9(3):215-219. Epub 2020 Mar 13.

Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, 438-8550, Japan.

A 70-year-old man diagnosed with lung adenocarcinoma was referred to our department for an evaluation of acute onset of nephrotic syndrome with acute kidney injury (AKI) after the 7th course of pembrolizumab treatment. Renal biopsy could not be performed, because he needed anticoagulation therapy for venous thrombosis. Pembrolizumab was discontinued, and prednisolone was started. Read More

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http://dx.doi.org/10.1007/s13730-020-00462-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320121PMC

Unexpected restoration of an arteriovenous graft function: the significance of vascular access surveillance.

CEN Case Rep 2020 Aug 10;9(3):291-293. Epub 2020 Mar 10.

Department of Nephrology, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41110, Larissa, Greece.

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http://dx.doi.org/10.1007/s13730-020-00460-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320096PMC

HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout.

CEN Case Rep 2020 Aug 3;9(3):210-214. Epub 2020 Mar 3.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Unlike complete deficiency of hypoxanthine phosphoribosyltransferase (HPRT) (i.e., Lesch-Nyhan syndrome), partial HPRT deficiency causes HPRT-related hyperuricemia without neurological symptoms. Read More

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http://dx.doi.org/10.1007/s13730-020-00459-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320122PMC

Crescentic IgA nephropathy after administration of human monoclonal interleukin-12/23p40 antibody in a patient with Crohn's disease: a case report.

CEN Case Rep 2020 Aug 25;9(3):204-209. Epub 2020 Feb 25.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.

Ustekinumab (UST), an interleukin (IL)-12/IL-23-blocking monoclonal antibody, is a novel therapeutic option for Crohn's disease (CD). We describe a 24-year-old man with CD who showed an abrupt decline in renal function after administration of UST. Twenty-nine months previously, the patient was diagnosed with CD, and abnormal urinalysis findings in health checkup were coincidentally found at that time. Read More

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http://dx.doi.org/10.1007/s13730-020-00457-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320091PMC