104 results match your criteria CBRNE - Vomiting Agents - Dm Da Dc


Acute Toxicity Related to Misuse (Non-Medical Use) of Tramadol: Experience of the European Drug Emergencies Network Plus (Euro-DEN Plus) Project.

Br J Clin Pharmacol 2020 Jun 5. Epub 2020 Jun 5.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.

Following the development of the tramadol crisis currently affecting countries in the Middle East, and Africa, there has been increasing international interest in the regulation of tramadol. This study investigates the misuse of tramadol in patients presenting to emergency departments across Europe. Data from 32 emergency departments in 21 countries were extracted from the Euro-DEN Plus database for the 4-year period from 1 January 2014 to 31 December 2017. Read More

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http://dx.doi.org/10.1111/bcp.14408DOI Listing

Antitumor, Anti-Inflammatory and Antiallergic Effects of Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, and : A Review of Preclinical and Clinical Studies.

Nutrients 2020 May 8;12(5). Epub 2020 May 8.

Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway.

Since the 1980s, medicinal effects have been documented in scientific studies with the related mushrooms Murill (AbM), (HE) and (GF) from Brazilian and Eastern traditional medicine. Special focus has been on their antitumor effects, but the mushrooms' anti-inflammatory and antiallergic properties have also been investigated. The antitumor mechanisms were either direct tumor attack, e. Read More

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http://dx.doi.org/10.3390/nu12051339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285126PMC

NETs analysed by novel calprotectin-based assays in blood donors and patients with multiple myeloma or rheumatoid arthritis: A pilot study.

Scand J Immunol 2020 May 4;91(5):e12870. Epub 2020 Mar 4.

Department of Immunology and Transfusion Medicine, Oslo University Hospital (OUH), Oslo, Norway.

Two novel enzyme-linked immunosorbent assays (ELISAs), designed to detect complexes containing DNA, leucocyte calprotectin and S100A12 proteins, were generated for improved specificity and rapid measurement of neutrophil extracellular traps (NETs). The assays were applied on plasma and serum samples from blood donors for establishment of reference values, and from patients with multiple myeloma (MM) or rheumatoid arthritis (RA) in order to examine putatively increased values in the two different inflammatory conditions. Although NETs were hardly detectable in healthy individuals, NET levels were as expected highly and statistically significantly increased in RA patients. Read More

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http://dx.doi.org/10.1111/sji.12870DOI Listing

Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes.

Basic Clin Pharmacol Toxicol 2020 Jul 5;127(1):47-51. Epub 2020 Feb 5.

Norwegian National Unit for CBRNE Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.

Paracetamol has a good safety profile, but pharmacogenetic differences in drug-metabolizing enzymes may have an impact on its risk of hepatotoxicity. We present a case of fatal acute liver failure (ALF) after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy, where pharmacogenetic screening was conducted. This 30-year-old man was electively admitted for a tracheostomy. Read More

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http://dx.doi.org/10.1111/bcpt.13389DOI Listing

Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum antipathogen inhibitor ABMA.

FEBS J 2020 Jan 4. Epub 2020 Jan 4.

Université Paris-Saclay, CEA, INRAE, Médicaments et Technologies pour la Santé (MTS), SIMoS, Gif-sur-Yvette, 91191, France.

The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins intoxication as well as pathogen infection. Read More

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http://dx.doi.org/10.1111/febs.15201DOI Listing
January 2020

Offline Next Generation Metagenomics Sequence Analysis Using MinION Detection Software (MINDS).

Genes (Basel) 2019 07 30;10(8). Epub 2019 Jul 30.

US Army, CCDC-Chemical Biological Center, Aberdeen Proving Ground, MD 21010, USA.

Field laboratories interested in using the MinION often need the internet to perform sample analysis. Thus, the lack of internet connectivity in resource-limited or remote locations renders downstream analysis problematic, resulting in a lack of sample identification in the field. Due to this dependency, field samples are generally transported back to the lab for analysis where internet availability for downstream analysis is available. Read More

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http://dx.doi.org/10.3390/genes10080578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723491PMC
July 2019
11 Reads

Consensus statements on the approach to patients in a methanol poisoning outbreak.

Clin Toxicol (Phila) 2019 12 22;57(12):1129-1136. Epub 2019 Jul 22.

The Norwegian CBRNE Centre of Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.

Methanol poisoning is an important cause of mortality and morbidity worldwide. Although it often occurs as smaller sporadic events, epidemic outbreaks are not uncommon due to the illicit manufacture and sale of alcoholic beverages. We aimed to define methanol poisoning outbreak (MPO), outline an approach to triaging an MPO, and define criteria for prioritizing antidotes, extracorporeal elimination treatments (i. Read More

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http://dx.doi.org/10.1080/15563650.2019.1636992DOI Listing
December 2019
17 Reads
3.122 Impact Factor

Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication.

Toxicol Lett 2019 Oct 10;314:37-42. Epub 2019 Jul 10.

Emergency Department, Hospital Clínic, Barcelona, IDIBAPS, Barcelona, Spain; Medical School, University of Barcelona, Spain.

Objective: Ethanol intake can increase the sedative effects of gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL), although the real clinical impact is unknown. We studied the clinical impact of the co-ingestion of ethanol in patients presenting to the Emergency Department (ED) with acute toxicity related to GHB/GBL use.

Method: We performed a secondary analysis of the Euro-DEN Plus Registry (14 countries, 22 EDs) which includes 17,371 consecutive patients presenting to the ED with acute recreational drug toxicity over 39 consecutive months (October 2013 - December 2016). Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.07.001DOI Listing
October 2019
21 Reads

Urine -2-Microglobulin, Osteopontin, and Trefoil Factor 3 May Early Predict Acute Kidney Injury and Outcome after Cardiac Arrest.

Crit Care Res Pract 2019 7;2019:4384796. Epub 2019 May 7.

Institute of Clinical Medicine, University of Oslo, P.O.Box 1072 Blindern, 0316 Oslo, Norway.

Purpose: Acute kidney injury (AKI) is a common complication after out-of-hospital cardiac arrest (OHCA), leading to increased mortality and challenging prognostication. Our aim was to examine if urine biomarkers could early predict postarrest AKI and patient outcome.

Methods: A prospective observational study of resuscitated, comatose OHCA patients admitted to Oslo University Hospital in Norway. Read More

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http://dx.doi.org/10.1155/2019/4384796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530154PMC
May 2019
22 Reads

Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) Science and the CBRNE Science Medical Operations Science Support Expert (CMOSSE).

Disaster Med Public Health Prep 2019 12;13(5-6):995-1010

Coalition for Epidemic Preparedness Innovations, London, England, UK.

A national need is to prepare for and respond to accidental or intentional disasters categorized as chemical, biological, radiological, nuclear, or explosive (CBRNE). These incidents require specific subject-matter expertise, yet have commonalities. We identify 7 core elements comprising CBRNE science that require integration for effective preparedness planning and public health and medical response and recovery. Read More

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http://dx.doi.org/10.1017/dmp.2018.163DOI Listing
December 2019
17 Reads
1.142 Impact Factor

Analysis by Monte Carlo of thermal neutron flux from a Am/Be source for a system of trace analysis in materials.

Appl Radiat Isot 2019 Sep 1;151:19-24. Epub 2019 May 1.

Departamento de Ingeniería Energética, ETSI Industriales, Universidad Politécnica de Madrid, José Gutiérrez Abascal 2, 28006, Madrid, Spain.

Neutron techniques to characterize materials have a wide range of applications, one of the major developments being the identification of terrorist threats with chemical, biological, radiological, nuclear and explosives (CBRNE) materials. In this work, a thermal neutron irradiation system, using aAm/Be source of 111 GBq inside polyethylene cylindrical moderators, has been designed, built and tested. The geometry of moderator and the neutron source position were fixed trying to maximize the thermal neutrons flux emitted from the system. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.04.041DOI Listing
September 2019
11 Reads

Characterizing the Current State of Training Courses Available to US Disaster Professionals.

Disaster Med Public Health Prep 2019 12;13(5-6):920-926

National Center for Disaster Medicine and Public Health, Uniformed Services University, Rockville, Maryland.

Objective: The objective of this study is to characterize US-based disaster training courses available to disaster response and disaster health professionals. Its purpose is to better inform policies and decision-making regarding workforce and professional development to improve performance.

Methods: Courses were identified from 4 inventories of courses: (1) National Library of Medicine Disaster Lit database; (2) TRAIN National Learning Network; (3) Federal Emergency Management Agency (FEMA) National Preparedness Course Catalog; and (4) Preparedness and Emergency Response Learning Centers. Read More

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http://dx.doi.org/10.1017/dmp.2019.15DOI Listing
December 2019
18 Reads

Methanol content in homemade alcohol from a province in North Vietnam.

Drug Alcohol Rev 2019 07 16;38(5):537-542. Epub 2019 May 16.

Norwegian National Unit for CBRNE Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.

Introduction And Aims: Methanol poisonings pose a major risk especially where illegal alcohol is consumed. The source of the methanol in the drinks are debated. We aimed to evaluate whether home distillation of alcohol made from rice was capable of producing toxic amounts of methanol. Read More

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http://dx.doi.org/10.1111/dar.12937DOI Listing
July 2019
16 Reads

Gender differences in acute recreational drug toxicity: a case series from Oslo, Norway.

BMC Emerg Med 2019 04 29;19(1):29. Epub 2019 Apr 29.

Oslo Accident and Emergency Outpatient Clinic, Department of Emergency General Practice, City of Oslo Health Agency, Oslo, Norway.

Background: Female drug users report poorer physical and mental health than male drug users. We describe female and male patients treated for acute recreational drug toxicity, and look for gender differences in clinical state, treatment, and toxic agents taken.

Methods: Retrospective case series from a primary care emergency outpatient clinic and a hospital emergency department in Oslo, Norway. Read More

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http://dx.doi.org/10.1186/s12873-019-0244-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489220PMC
April 2019
19 Reads

Development and Implementation of a Disaster Medicine Certificate Series (DMCS) for Medical Students.

Prehosp Disaster Med 2019 Apr 14;34(2):197-202. Epub 2019 Apr 14.

2.Department of Emergency Medicine, Division of Disaster Medicine,Beth Israel Deaconess Medical Center,Boston, Massachusetts,USA.

Introduction: The recent increase in natural disasters and mass shootings highlights the need for medical providers to be prepared to provide care in extreme environments. However, while physicians of all specialties may respond in emergencies, disaster medicine training is minimal or absent from most medical school curricula in the United States. A voluntary Disaster Medicine Certificate Series (DMCS) was piloted to fill this gap in undergraduate medical education. Read More

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http://dx.doi.org/10.1017/S1049023X19000165DOI Listing
April 2019
21 Reads

Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set.

Neurotoxicology 2019 07 8;73:183-187. Epub 2019 Apr 8.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK; Clinical Toxicology, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug Emergencies Plus (Euro-DEN Plus) Network, to compare presentations with and without seizures and estimate incidence and associated drugs. Amongst 23,947 presentations between January 2014 and December 2017, there were 1013 (4. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X193003
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http://dx.doi.org/10.1016/j.neuro.2019.04.003DOI Listing
July 2019
29 Reads

New filovirus disease classification and nomenclature.

Nat Rev Microbiol 2019 05;17(5):261-263

World Health Organization Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.

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http://dx.doi.org/10.1038/s41579-019-0187-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637750PMC
May 2019
27 Reads
23.574 Impact Factor

Impact of Gas Masks on the Work of Breathing and Breathing Pattern in Subjects With Stable COPD.

Respir Care 2019 Sep 26;64(9):1049-1056. Epub 2019 Mar 26.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.

Background: The gas mask constitutes the main respiratory protective equipment in a chemical, biological, radiological, or nuclear environment. The aim of the study was to evaluate the impact of the gas mask on respiratory pattern, gas exchange, and indexes of respiratory effort in patients with moderate to severe stable COPD.

Methods: Crossover evaluation with 3 randomized-order, 10-min conditions: at rest and with and without a gas mask using 2 different filtered cartridges, each with a distinct inspiratory resistance (cartridge A = 3. Read More

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http://dx.doi.org/10.4187/respcare.06550DOI Listing
September 2019
14 Reads

DETECTION OF IONIZING RADIATION TREATMENT IN GLASS USED FOR HEALTHCARE PRODUCTS.

Radiat Prot Dosimetry 2019 Dec;186(1):78-82

Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma, Italy.

The treatment with high doses of ionizing radiation is prescribed for the terminal sterilization of many healthcare products. In order to check the product irradiation, it may be useful to develop suitable detection methods. The aim of this work was to verify the suitability of the thermoluminescence (TL) and electron paramagnetic resonance (EPR) techniques to reveal illegal omission of radiation sterilization in glass used for blood test tubes. Read More

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http://dx.doi.org/10.1093/rpd/ncz014DOI Listing
December 2019
20 Reads

Preparedness for chemical crisis situations: experiences from European medical response exercises.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1239-1247

Comprehensive Defence Division, Norwegian Defence Research Establishment, Kjeller, Norway.

Objective: This study investigated how European first responders and hospital personnel, along with CBRN experts, approach an overwhelming surge situation after a chemical incident. Surge capacity and capability bottlenecks were discussed.

Materials And Methods: Two chemical warfare agent (CWA) scenarios were developed: in the first, a nerve agent was released indoors; in the second, there was an outdoor explosion containing a blister agent. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17017DOI Listing
February 2019
17 Reads

Thermodynamic Studies on a Hydrogen Bonded Acidic 3,5-Bis(trifluoromethyl)phenol-functionalized Polymer as a Gas Chromatography Stationary Phase for Selectively Speciating Chemical Warfare Agents.

Anal Sci 2019 Jun 15;35(6):671-677. Epub 2019 Feb 15.

Nano & Micro Sensors Department, Sandia National Laboratories.

We describe for the first time hydrogen bonded acid (HBA) polymer, poly{methyl[3-(2-hydroxyl, 4,6-bistrifluoromethyl)phenyl]propylsiloxane}, (DKAP), as stationary phase for gas chromatography (μGC) of organophosphate (OP), chemical warfare agent (CWA) surrogates, dimethylmethylphosphonate (DMMP), diisopropylmethylphosphonate (DIMP), diethylmethylphosphonate (DEMP), and trimethylphosphate (TMP), with high selectivity. Absorption of OPs to DKAP was one-to-several orders of magnitude higher relative to commercial polar, mid-polar, and nonpolar stationary phases. We also present for the first-time thermodynamic studies on the absorption of OP vapors and quantitative binding energy data for interactions with various stationary phases. Read More

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http://dx.doi.org/10.2116/analsci.18P537DOI Listing
June 2019
19 Reads

Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases.

Clin Toxicol (Phila) 2019 Aug 30;57(8):718-726. Epub 2019 Jan 30.

Emergency Department , Hospital Clínic, Barcelona; IDIBAPS , Barcelona , Spain.

: To analyse the epidemiology, clinical picture and emergency department (ED) management of a large series of patients who presented to European EDs after cocaine consumption, comparing data from powder (C group) and crack (C group) consumers. : Between October 2013 and December 2016, the Euro-DEN Plus Registry recorded 17,371 consecutive acute recreational drug toxicity presentations to 22 EDs in 14 European countries. Epidemiological and demographic data, co-ingestion of alcohol and other drugs, clinical features, ED management and outcome (death) were analysed for cocaine cases, and comparison of clinical picture in C and C patients were performed adjusting for alcohol and other drug co-ingestion. Read More

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http://dx.doi.org/10.1080/15563650.2018.1549735DOI Listing
August 2019
22 Reads

Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas.

Emergencias 2018 Dic;30(6):385-394

Área de Urgencias, Hospital Clínic, Barcelona; Grupo de Investigación "Urgencias: Procesos y Patologías", IDIBAPS, Barcelona, España.

Objectives: To analyze epidemiologic, clinical, and care characteristics in cases in which patients came to 2 Spanish emergency departments (EDs) with symptoms caused by recreational drug abuse. To compare the characteristics with those reported for other areas of Europe.

Material And Methods: Secondary analysis of the registry of the European Drug Emergencies Network (Euro-DEN Plus), which collects cases in 14 European countries and 20 EDs. Read More

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July 2019
49 Reads

Poor Identification of Emergency Department Acute Recreational Drug Toxicity Presentations Using Routine Hospital Coding Systems: the Experience in Denmark, Switzerland and the UK.

J Med Toxicol 2019 04 2;15(2):112-120. Epub 2019 Jan 2.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, St Thomas' Hospital, 3rd Floor, Block C, South Wing, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Understanding emergency department and healthcare utilisation related to acute recreational drug toxicity (ARDT) generally relies on nationally collated data based on ICD-10 coding. Previous UK studies have shown this poorly captures the true ARDT burden. The aim of this study was to investigate whether this is also the case elsewhere in Europe. Read More

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http://link.springer.com/10.1007/s13181-018-0687-z
Publisher Site
http://dx.doi.org/10.1007/s13181-018-0687-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440929PMC
April 2019
41 Reads

Emergency Department Response to Chemical, Biological, Radiological, Nuclear, and Explosive Events: A Systematic Review.

Prehosp Disaster Med 2018 Oct;33(5):543-549

Loughborough Design School,Loughborough University,Leicestershire,UK.

IntroductionA Chemical, Biological, Radiological, Nuclear, and explosive (CBRNe) event is an emergency which can result in injury, illness, or loss of life. The emergency department (ED) as a health system is at the forefront of the CBRNe response with staff acting as first receivers. Emergency departments are under-prepared to respond to CBRNe events - recognizing key factors which underlie the ED CBRNe response is crucial to provide evidence-based knowledge to inform policies and, most importantly, clinical practice. Read More

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http://dx.doi.org/10.1017/S1049023X18000900DOI Listing
October 2018
30 Reads

Emergency Preparedness Training for Hospital Nursing Staff, New York City, 2012-2016.

J Nurs Scholarsh 2019 01 17;51(1):81-87. Epub 2018 Sep 17.

Director, Hospital Readiness and Health Care Coalitions, Office of Emergency Preparedness and Response, New York City Department of Health and Mental Hygiene, New York, NY, USA.

Purpose: Many nurses are trained inadequately in emergency preparedness (EP), preventing them from effectively executing response roles during disasters, such as chemical, biological, radiological, nuclear, and explosive (CBRNE) events. Nurses also indicate lacking confidence in their abilities to perform EP activities. The purpose of this article is to describe the phased development of, and delivery strategies for, a CBRNE curriculum to enhance EP among nursing professionals. Read More

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http://doi.wiley.com/10.1111/jnu.12425
Publisher Site
http://dx.doi.org/10.1111/jnu.12425DOI Listing
January 2019
31 Reads

Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data.

Eur J Clin Pharmacol 2019 Jan 22;75(1):77-85. Epub 2018 Sep 22.

Clinical Toxicology, Guy's and St Thomas' Hospitals NHS Foundation Trust, and King's Health Partners, London, UK.

Background: Non-medical use of benzodiazepines and Z-drugs is common; however, there is limited information available on the extent of harm related to this in Europe, as well as the relationship between misuse and availability.

Aim: To describe presentations to the emergency department in Europe related to the recreational use of benzodiazepines and Z-drugs and compare regional differences in these presentations with legal drug sales of benzodiazepines and Z-drugs within each country.

Methods: Emergency department presentations with recreational misuse of benzodiazepines and Z-drugs were obtained from the Euro-DEN dataset for the period from October 2013 to September 2015; data extracted included demographics, clinical features, reported coused drugs, and outcome data. Read More

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http://link.springer.com/10.1007/s00228-018-2550-1
Publisher Site
http://dx.doi.org/10.1007/s00228-018-2550-1DOI Listing
January 2019
48 Reads

Concurrent Use of Benzodiazepine by Heroin Users-What Are the Prevalence and the Risks Associated with This Pattern of Use?

J Med Toxicol 2019 01 31;15(1):4-11. Epub 2018 Jul 31.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.

Introduction: Polydrug use involving heroin and benzodiazepines is common. The potential risk of additive pharmacological effects may be associated with poorer outcomes in patients who use benzodiazepines together with heroin. The aim of this study was to determine the clinical picture of patients presenting to the emergency department following acute drug toxicity involving heroin and benzodiazepines. Read More

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http://dx.doi.org/10.1007/s13181-018-0674-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314928PMC
January 2019
16 Reads

Preparedness and response against diseases with epidemic potential in the European Union: a qualitative case study of Middle East Respiratory Syndrome (MERS) and poliomyelitis in five member states.

BMC Health Serv Res 2018 07 6;18(1):528. Epub 2018 Jul 6.

European Centre for Disease Prevention and Control, Granits väg 8, 171 65, Solna, Sweden.

Background: EU Decision 1082/2013/EU on serious cross-border health threats provides a legal basis for collaboration between EU Member States, and between international and European level institutions on preparedness, prevention, and mitigation in the event of a public health emergency. The Decision provides a context for the present study, which aims to identify good practices and lessons learned in preparedness and response to Middle East Respiratory Syndrome (MERS) (in UK, Greece, and Spain) and poliomyelitis (in Poland and Cyprus).

Methods: Based on a documentary review, followed by five week-long country visits involving a total of 61 interviews and group discussions with experts from both the health and non-health sectors, this qualitative case study has investigated six issues related to preparedness and response to MERS and poliomyelitis: national plans and overall preparedness capacity; training and exercises; risk communication; linking policy and implementation; interoperability between the health and non-health sectors; and cross-border collaboration. Read More

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http://dx.doi.org/10.1186/s12913-018-3326-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034236PMC
July 2018
45 Reads

The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients With Methanol Poisoning - An Observational Study of 35 Patients.

Basic Clin Pharmacol Toxicol 2018 Dec 23;123(6):749-755. Epub 2018 Jul 23.

Department of Acute Medicine, Division of Medicine, Oslo University Hospital, Oslo, Norway.

Methanol mass poisoning is a global problem with high fatality rates and often severe sequelae in survivors. Patients typically present late to the hospital with severe metabolic acidosis followed by a rapid deterioration in their clinical status. The hypothesis 'Circulus hypoxicus' describes the metabolic acidosis following methanol poisoning as a self-enhancing hypoxic circle responsible for methanol toxicity. Read More

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http://dx.doi.org/10.1111/bcpt.13074DOI Listing
December 2018
54 Reads

Proposed "Exposure And Symptom Triage" (EAST) Tool to Assess Radiation Exposure After a Nuclear Detonation.

Disaster Med Public Health Prep 2018 Jun 31;12(3):386-395. Epub 2017 Jul 31.

CBRNE Science and Operations, US Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Office of Emergency Management, Washington, DC.

ABSTRACTOne of the biggest medical challenges after the detonation of a nuclear device will be implementing a strategy to assess the severity of radiation exposure among survivors and to triage them appropriately. Those found to be at significant risk for radiation injury can be prioritized to receive potentially lifesaving myeloid cytokines and to be evacuated to other communities with intact health care infrastructure prior to the onset of severe complications of bone marrow suppression. Currently, the most efficient and accessible triage method is the use of sequential complete blood counts to assess lymphocyte depletion kinetics that correlate with estimated whole-body dose radiation exposure. Read More

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http://dx.doi.org/10.1017/dmp.2017.86DOI Listing
June 2018
8 Reads

What's in a Rash? Viral Exanthem Versus CBRNE Exposure: Teleconsultation Support for Two Special Forces Soldiers With Diffuse Rash in an Austere Environment.

J Spec Oper Med Summer 2018;18(2):133-135

Objective: Review clinical thought process and key principles for diagnosing weaponized chemical and biologic injuries. Clinical Context: Special Operation Forces (SOF) team deployed in an undisclosed, austere environment. Organic Expertise: Two SOF Soldiers with civilian EMT-Basic certification. Read More

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October 2018
22 Reads

Good practices and challenges in addressing poliomyelitis and measles in the European Union.

Eur J Public Health 2018 08;28(4):730-734

Crisis Management and Preparedness in Health Unit, Public Health Directorate, Directorate-General for Health and Food Safety (DG SANTE), European Commission, Luxembourg, Luxembourg.

Background: All European Union (EU) and European Economic Area (EEA) Member States have pledged to ensure political commitment towards sustaining the region's poliomyelitis-free status and eliminating measles. However, there remain significant gaps between policy and practice in many countries. This article reports on an assessment conducted for the European Commission that aimed to support improvements in preparedness and response to poliomyelitis and measles in Europe. Read More

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http://dx.doi.org/10.1093/eurpub/cky056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051453PMC
August 2018
24 Reads

Comparison of three haemodynamic monitoring methods in comatose post cardiac arrest patients.

Scand Cardiovasc J 2018 06 16;52(3):141-148. Epub 2018 Mar 16.

d Department of Cardiology, Division of Medicine , Oslo University Hospital , Oslo , Norway.

Objectives: Haemodynamic monitoring during post arrest care is important to optimise treatment. We compared stroke volume measured by minimally-invasive monitoring devices with or without thermodilution calibration, and transthoracic echocardiography (TTE), and hypothesised that thermodilution calibration would give stroke volume index (SVI) more in agreement with TTE during targeted temperature management (TTM).

Design: Comatose out-of-hospital cardiac arrest survivors receiving TTM (33 °C for 24 hrs) underwent haemodynamic monitoring with arterial pulse contour analyses with (PiCCO2®) and without (FloTrac/Vigileo monitor) transpulmonary thermodilution calibration. Read More

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http://dx.doi.org/10.1080/14017431.2018.1450992DOI Listing
June 2018
26 Reads

Integrating Chemical Biological, Radiologic, and Nuclear (CBRN) Protocols Into TCCC Introduction of a Conceptual Model - TCCC + CBRN = (MARCHE)2.

J Spec Oper Med Spring 2018;18(1):118-123

The authors would like to introduce TCCC [Tactical Combat Casualty Care] + CBRN [chemical, biological, radiological, and nuclear] = (MARCHE)2 as a conceptual model to frame the response to CBRN events. This model is not intended to replace existing and well-established literature on CBRNE events but rather to serve as a response tool that is an adjunct to agent specific resources. Read More

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May 2018
106 Reads

Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series.

Medicine (Baltimore) 2018 02;97(5):e9784

Division of Clinical Pharmacology and Toxicology, Basel University Hospital and University of Basel, Basel, Switzerland.

The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Read More

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http://dx.doi.org/10.1097/MD.0000000000009784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805445PMC
February 2018
56 Reads

Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims.

Acta Anaesthesiol Scand 2017 Oct 17;61(9):1142-1154. Epub 2017 Aug 17.

Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: Acute fire smoke inhalation injury involves inflammatory mediators whose roles are poorly understood. We carried out a prospective observational study of fire smoke victims to identify clinical and biochemical markers that may predict pulmonary dysfunction and investigated possible correlations between dysfunction and cytokines in bronchoalveolar lavage (BAL) fluid and blood.

Methods: Forty patients with respiratory and/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months. Read More

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http://dx.doi.org/10.1111/aas.12962DOI Listing
October 2017
22 Reads

The draft genome of the hyperthermophilic archaeon strain hulk, an iron and nitrate reducer, reveals the capacity for sulfate reduction.

Stand Genomic Sci 2017 15;12:47. Epub 2017 Aug 15.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI USA.

strain Hulk is a newly sequenced strain isolated from chimney samples collected from the Hulk sulfide mound on the main Endeavour Segment of the Juan de Fuca Ridge (47.9501 latitude, -129.0970 longitude, depth 2200 m) in the Northeast Pacific Ocean. Read More

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http://dx.doi.org/10.1186/s40793-017-0260-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556600PMC
August 2017
26 Reads

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks.

Ann Intensive Care 2017 Dec 20;7(1):77. Epub 2017 Jul 20.

The Norwegian CBRNE Centre of Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.

Background: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors. Read More

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http://dx.doi.org/10.1186/s13613-017-0300-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519513PMC
December 2017
66 Reads

Mass-Fatality Incident Preparedness Among Faith-Based Organizations.

Prehosp Disaster Med 2017 Dec 4;32(6):596-603. Epub 2017 Jul 4.

1Phillip R. Lee Institute for Health Policy Studies,School of Medicine,University of California,San Francisco,San Francisco,CaliforniaUSA.

Introduction Members of faith-based organizations (FBOs) are in a unique position to provide support and services to their local communities during disasters. Because of their close community ties and well-established trust, they can play an especially critical role in helping communities heal in the aftermath of a mass-fatality incident (MFI). Faith-based organizations are considered an important disaster resource and partner under the National Response Plan (NRP) and National Response Framework; however, their level of preparedness and response capabilities with respect to MFIs has never been evaluated. Read More

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http://dx.doi.org/10.1017/S1049023X17006665DOI Listing
December 2017
25 Reads

Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse.

Toxicol Lett 2017 Aug 1;277:84-91. Epub 2017 Jun 1.

Pomeranian Centre of Toxicology, Gdansk, Poland; Medical University Gdansk, Department of Clinical Toxicology, Gdansk, Poland.

Objective: To study the profile of European gamma-hydroxybutyrate (GHB) and gammabutyrolactone (GBL) intoxication and analyse the differences in the clinical manifestations produced by intoxication by GHB/GBL alone and in combination with other substances of abuse.

Method: We prospectively collected data on all the patients attended in the Emergency Departments (ED) of the centres participating in the Euro-DEN network over 12 months (October 2013 to September 2014) with a primary presenting complaint of drug intoxication (excluding ethanol alone) and registered the epidemiological and clinical data and outcomes.

Results: We included 710 cases (83% males, mean age 31 years), representing 12. Read More

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http://dx.doi.org/10.1016/j.toxlet.2017.05.030DOI Listing
August 2017
114 Reads

Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway.

Clin Toxicol (Phila) 2017 Aug 13;55(7):636-644. Epub 2017 Apr 13.

f The Norwegian CBRNe Centre of Medicine, Department of Acute Medicine , Oslo University Hospital , Oslo , Norway.

Context: Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. Read More

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http://dx.doi.org/10.1080/15563650.2017.1312002DOI Listing
August 2017
27 Reads

Reply to "Letter in response to efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning".

Clin Toxicol (Phila) 2017 04;55(4):306-307

c The Norwegian CBRNe Centre of Medicine, Department of Acute Medicine , Oslo University Hospital , Oslo , Norway.

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http://dx.doi.org/10.1080/15563650.2017.1284338DOI Listing
April 2017
52 Reads

[Tattooed norwegian tourist with fever and rashes].

Tidsskr Nor Laegeforen 2017 02 7;137(3):205-207. Epub 2017 Feb 7.

Infeksjonsmedisinsk avdeling Oslo universitetssykehus, Ullevål og Nasjonal behandlingstjeneste for CBRNE-medisin Oslo universitetssykehus.

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http://dx.doi.org/10.4045/tidsskr.16.0710DOI Listing
February 2017
20 Reads

The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse.

PLoS One 2016 21;11(12):e0167754. Epub 2016 Dec 21.

Norwegian University of Life Sciences, Department of Food Safety and Infection Biology, Oslo, Norway.

Background: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine against cancer and other diseases. The mushroom contains immunomodulating β-glucans and is shown to have antitumor effects in murine cancer models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167754PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176274PMC
July 2017
49 Reads

Evaluation of Hospitals' Disaster Preparedness Plans in the Holy City of Makkah (Mecca): A Cross-Sectional Observation Study.

Prehosp Disaster Med 2017 Feb 14;32(1):33-45. Epub 2016 Dec 14.

3Harvard Medical Faculty Physicians Fellowship in Disaster Medicine, an affiliated fellowship of the Harvard Humanitarian Initiative,Harvard University,Boston,Massachusetts,USA.

Background: Makkah (Mecca) is a holy city located in the western region of the Kingdom of Saudi Arabia. Each year, millions of pilgrims visit Makkah. These numbers impact both routine health care delivery and disaster response. Read More

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http://dx.doi.org/10.1017/S1049023X16001229DOI Listing
February 2017
41 Reads

Erratum to: Psychosis associated with acute recreational drug toxicity: a European case series.

BMC Psychiatry 2016 11 16;16(1):405. Epub 2016 Nov 16.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.

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http://dx.doi.org/10.1186/s12888-016-1066-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112744PMC
November 2016
54 Reads

Deployment of the 1st Area Medical Laboratory in a Split-Based Configuration During the Largest Ebola Outbreak in History.

Mil Med 2016 11;181(11):e1675-e1684

1st Area Medical Laboratory Building 5116, Bel Air Street, Aberdeen Proving Ground, MD 21005.

Background: The U.S. Army 1 Area Medical Laboratory (1 AML) is currently the only deployable medical CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosives) laboratory in the Army's Forces Command. Read More

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http://dx.doi.org/10.7205/MILMED-D-15-00484DOI Listing
November 2016
25 Reads