6,288 results match your criteria CBD Lipid Signaling [Journal]


Sphincterotomy plus balloon dilation versus sphincterotomy alone for choledocholithiasis: a meta-analysis.

Endoscopy 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background:  Endoscopic sphincterotomy plus balloon dilation (ESBD) is considered to be a promising method for the removal of large common bile duct (CBD) stones. However, when compared with endoscopic sphincterotomy (EST) alone, the efficacy and safety of ESBD remain controversial. This meta-analysis aimed to compare the efficacy and safety of ESBD vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0848-8271DOI Listing
February 2019

Digital cholangioscopy-guided laser versus mechanical lithotripsy for large bile duct stone removal after failed papillary large-balloon dilation: a randomized study.

Endoscopy 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background:  Endoscopic papillary large-balloon dilation (EPLBD) allows for the complete removal of large common bile duct (CBD) stones without fragmentation; however, a significant proportion of very large stones and stones floating above a tapering CBD require lithotripsy. Mechanical lithotripsy and cholangioscopy-guided laser lithotripsy are both effective for stone fragmentation. This study aimed to directly compare, for the first time, the efficacy of these two techniques in terms of stone clearance rate, procedure duration, patient radiation exposure, and safety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0848-8373DOI Listing
February 2019

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.

Oncotarget 2019 Jan 25;10(8):825-846. Epub 2019 Jan 25.

Center for Radiological Research, Department of Radiation Oncology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance radiosensitivity of GBM but not normal astrocytes. Inhibition of ATM kinase is an alternative mechanism for radiosensitization of cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368233PMC
January 2019

Spatio-Temporal Dynamics of Arabica Coffee Berry Disease Caused by Colletotrichum kahawae on a Plot Scale.

Plant Dis 2007 Oct;91(10):1229-1236

CIRAD-INRA-ENSAM, UMR BGPI, Campus International de Baillarguet, TA41/k, 34398 Montpellier Cedex 5 France.

Coffee berry disease (CBD) is caused by Colletotrichum kahawae. This pathogen only attacks green berries; it causes cherry rot and premature fruit fall. The disease leads to major harvest losses in the western highland region of Cameroon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1094/PDIS-91-10-1229DOI Listing
October 2007

Adsorption and Desorption of Carbendazim and Thiamethoxam in Five Different Agricultural Soils.

Bull Environ Contam Toxicol 2019 Feb 18. Epub 2019 Feb 18.

Institute of Pesticide and Environmental Toxicology, College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China.

The adsorption and desorption behaviors of carbendazim (CBD) and thiamethoxam (TMX) were systematically studied in five different agricultural soils. The adsorption and desorption isotherms of CBD and TMX in the five different soils were fitted well by the Freundlich model. The Freundlich adsorption coefficient (K) and Freundlich desorption coefficient (K) of CBD in the five different soils were 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00128-019-02568-3DOI Listing
February 2019

The Potential Clinical Implications and Importance of Drug Interactions Between Anticancer Agents and Cannabidiol in Patients With Cancer.

J Pharm Pract 2019 Feb 18:897190019828920. Epub 2019 Feb 18.

2 Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, USA.

The objective of this review was to identify and examine the pharmacokinetic and pharmacodynamic interactions between cannabidiol (CBD)-only products, such as CBD oil, and anticancer agents. A literature search of PubMed (1980 to September 2018) and the Cochrane Collection (1980 to September 2018) was performed using the following search terms: "cannabidiol," "cancer," "cannabis," "marijuana," and "interaction," as well as any combination of these terms. Literature was excluded if it did not appear in the search when limited to the "full text" filter on PubMed, if it was not published in the English language, or if it did not explore potential pharmacodynamic or pharmacokinetic interactions of CBD and anticancer agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0897190019828920DOI Listing
February 2019

U.K. hemophilia treaters' knowledge of risk assessment for prolonged bleeding associated with dental procedures.

Spec Care Dentist 2019 Feb 17. Epub 2019 Feb 17.

Professor and Consultant in Special Care Dentistry , Division of Public & Child Dental Health, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Lincoln Place, Dublin 2.

Introduction: Optimal delivery of dental care for adults with congenital bleeding disorders (CBD) requires close collaboration between hemophilia treaters and dentists.

Aim: To explore U.K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/scd.12359DOI Listing
February 2019

Prevalence and correlates of medical cannabis patients' use of cannabis for recreational purposes.

Addict Behav 2019 Feb 7;93:233-239. Epub 2019 Feb 7.

Oberlin College, Department of Psychology, 120 West Lorain Street, Oberlin, OH 44074, USA. Electronic address:

Background: Rates of legal medical cannabis (MC) use are increasing, but little is known about the prevalence and correlates of recreational cannabis (RC) use among medical users (MC/R).

Methods: 348 MC users who resided in a state in which MC is legal and had medical authorization to use MC legally completed an anonymous survey in Spring 2017 (64.1% female, 82. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addbeh.2019.02.003DOI Listing
February 2019

Predictive criteria of response to endoscopic treatment for severe strictures in primary sclerosing cholangitis.

Clin Res Hepatol Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris AP-HP, Sorbonne university, 75012 Paris, France. Electronic address:

Background: The aim of this study was to identify predictive criteria of improvement after endoscopic treatment (ET) for severe strictures of extrahepatic bile ducts in patients with primary sclerosing cholangitis (PSC).

Methods: PSC patients who had at least one ET for severe stricture were included. Features of magnetic resonance cholangiography (MRC), performed before ET, were evaluated according to a standard model of interpretation, and a radiologic qualitative score of probability of improvement after ET was built. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinre.2019.01.003DOI Listing
February 2019
1 Read

The malate-activated ALMT12 anion channel in the grass is co-activated by Ca/calmodulin.

J Biol Chem 2019 Feb 15. Epub 2019 Feb 15.

University of Saskatchewan, Canada.

In plants, strict regulation of stomatal pores is critical for modulation of CO fixation and transpiration. Under certain abiotic and biotic stressors, pore closure is initiated through anionic flux, with calcium (Ca), playing a central role. The aluminum-activated malate transporter 12 (ALMT12) is a malate-activated, voltage-dependent member of the aluminum-activated malate transporter family, implicated in anionic flux from guard cells controlling stomatal aperture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.005301DOI Listing
February 2019

Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias: study protocol of a randomized controlled trial.

BMC Psychiatry 2019 Feb 13;19(1):69. Epub 2019 Feb 13.

Department of Experimental Psychology and Helmholtz Institute, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.

Background: Phobic anxiety disorders are among the most prevalent psychiatric disorders and are burdensome in terms of loss of quality of life and work productivity. Evidence-based treatments are relatively successful in the majority of patients, especially exposure therapy. However, a substantial subset of patients fails to achieve or stay in remission. Read More

View Article

Download full-text PDF

Source
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12888-019-2022-xDOI Listing
February 2019
3 Reads

Billroth-I reconstruction using an overlap method in totally laparoscopic distal gastrectomy: propensity score matched cohort study of short- and long-term outcomes compared with Roux-en-Y reconstruction.

Surg Endosc 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-ku, Kitakyushu, 802-0077, Japan.

Background: Delta-shaped anastomosis is an established procedure for intracorporeal Billroth-I reconstruction (B-I). However, this procedure has several technical and economic problems. The aim of the current study was to present the technique of B-I using an overlap method (overlap B-I), which is a side-to-side intracorporeal gastroduodenostomy in laparoscopic distal gastrectomy (LDG), and to evaluate the short- and long-term outcomes of this overlap B-I procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-019-06688-zDOI Listing
February 2019

Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder.

Neuropsychopharmacology 2019 Feb 6. Epub 2019 Feb 6.

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

There is increasing interest in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders, such as autism spectrum disorder (ASD). However, before launching large-scale clinical trials, a better understanding of the effects of CBD on brain would be desirable. Preclinical evidence suggests that one aspect of the polypharmacy of CBD is that it modulates brain excitatory glutamate and inhibitory γ-aminobutyric acid (GABA) levels, including in brain regions linked to ASD, such as the basal ganglia (BG) and the dorsomedial prefrontal cortex (DMPFC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-019-0333-8DOI Listing
February 2019

Management of Bouveret's Syndrome.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri,, United States.

Bouveret's syndrome is a rare condition characterized by gastric outlet obstruction caused by gallstone impaction in the stomach or duodenum. Gallstones that are too large to pass through the cystic and common bile ducts (CBD) can result in chronic irritation and inflammation of the gallbladder wall. This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1751-2980.12713DOI Listing
February 2019

Chromophore binding to two cysteines increases quantum yield of near-infrared fluorescent proteins.

Sci Rep 2019 Feb 12;9(1):1866. Epub 2019 Feb 12.

Institut für Chemie, Sekr. PC14, Technische Universität Berlin, Straße des 17. Juni 135, 10623, Berlin, Germany.

Phytochromes are red/far-red light sensing photoreceptors employing linear tetrapyrroles as chromophores, which are covalently bound to a cysteine (Cys) residue in the chromophore-binding domain (CBD, composed of a PAS and a GAF domain). Recently, near-infrared (NIR) fluorescent proteins (FPs) engineered from bacterial phytochromes binding biliverdin IXα (BV), such as the iRFP series, have become invaluable probes for multicolor fluorescence microscopy and in vivo imaging. However, all current NIR FPs suffer from relatively low brightness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-38433-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372600PMC
February 2019
1 Read

Performance of low-literate community health workers treating severe acute malnutrition in South Sudan.

Matern Child Nutr 2019 Jan;15 Suppl 1:e12716

Health Unit, International Rescue Committee, New York, New York, USA.

Previous studies have described barriers to access of childhood severe acute malnutrition (SAM) treatment, including long travel distances and high opportunity costs. To increase access in remote communities, the International Rescue Committee developed a simplified SAM treatment protocol and low-literacy-adapted tools for community-based distributors (CBD, the community health worker cadre in South Sudan) to deliver treatment in the community. A mixed-methods pilot study was conducted to assess whether low-literate CBDs can adhere to a simplified SAM treatment protocol and to examine the community acceptability of CBDs providing treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/mcn.12716DOI Listing
January 2019

Influence of Trainer Role, Subspecialty and Hospital Status on Consultant Workplace-based Assessment Completion.

J Surg Educ 2019 Feb 8. Epub 2019 Feb 8.

Wales Deanery PGMDE School of Surgery, Health Education and Improvement Wales, Nantgarw, Cardiff, United Kingdom. Electronic address:

Objective: Performance assessment is challenging to administer and validate, yet remains central to patient safety and quality of care. The aim of this study was to evaluate Consultant Surgeon trainer performance with respect to Workplace Based Assessment (WBA) completion.

Design: All WBAs for 60 Core Surgical Trainees (n = 2932) recorded in one academic year were analyzed using the Intercollegiate Surgical Curriculum Progamme. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsurg.2019.01.013DOI Listing
February 2019

miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia-Effect of cannabinoids.

PLoS One 2019 11;14(2):e0212039. Epub 2019 Feb 11.

The Dr Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Mammalian microRNAs (miRNAs) play a critical role in modulating the response of immune cells to stimuli. Cannabinoids are known to exert beneficial actions such as neuroprotection and immunosuppressive activities. However, the underlying mechanisms which contribute to these effects are not fully understood. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212039PLOS
February 2019

Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

GW Research Ltd, Cambridge, UK.

Objective: Patients with Lennox-Gastaut syndrome (LGS) who completed 1 of 2 randomized, double-blind, placebo-controlled trials of add-on cannabidiol (CBD) (GWPCARE3, NCT02224560 or GWPCARE4, NCT02224690) were invited to enroll in an open-label extension (OLE) study evaluating the long-term safety and efficacy of CBD (GWPCARE5, NCT02224573). Herein we present an interim analysis of the safety, efficacy, and patient-reported outcomes from this trial.

Methods: Patients received a pharmaceutical formulation of highly purified CBD oral solution (Epidiolex; 100 mg/mL), titrated from 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14670DOI Listing
February 2019
1 Read

Development of a validated method for the qualitative and quantitative analysis of cannabinoids in plant biomass and medicinal cannabis resin extracts obtained by super-critical fluid extraction.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 30;1109:76-83. Epub 2019 Jan 30.

Agriculture Victoria Research, AgriBio, Centre for AgriBioscience, Bundoora, VIC 3083, Australia.

The social push for the therapeutic use of cannabis extracts has increased significantly over recent years. Cannabis is being used for treatment for conditions such as epilepsy, cancer and pain management. There are a range of medicinal cannabis products available, but the use of cannabis resin obtained by super critical fluid extraction, often diluted in oil, is becoming increasingly more prominent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2019.01.027DOI Listing
January 2019

Bax to the future - A novel, high-yielding approach for purification and expression of full-length Bax protein for structural studies.

Protein Expr Purif 2019 Feb 6;158:20-26. Epub 2019 Feb 6.

Department of Chemistry, University of Umeå, SE-901 87, Umeå, Sweden. Electronic address:

Mitochondria-mediated apoptosis (programmed cell death) involves a sophisticated signaling and regulatory network that is regulated by the Bcl-2 protein family. Members of this family have either pro- or anti-apoptotic functions. An important pro-apoptotic member of this family is the cytosolic Bax. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2019.02.004DOI Listing
February 2019
1 Read

Domain structure and expression along the midgut and carcass of peritrophins and cuticle proteins analogous to peritrophins in insects with and without peritrophic membrane.

J Insect Physiol 2019 Feb 5;114:1-9. Epub 2019 Feb 5.

Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. Electronic address:

Most insects have a peritrophic membrane (matrix) (PM) surrounding the food bolus. This structure, similarly to the cuticle, is mainly composed of chitin and proteins. The main proteins forming PM are known as peritrophins (PMP), whereas some of the cuticle proteins are the cuticle proteins analogous to peritrophins (CPAP). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00221910183044
Publisher Site
http://dx.doi.org/10.1016/j.jinsphys.2019.02.002DOI Listing
February 2019
2 Reads

A soybean-based diet modulates cadmium-induced vascular apoptosis.

J Trace Elem Med Biol 2019 Mar 11;52:239-246. Epub 2019 Jan 11.

Laboratory of Experimental and Translational Medicine, Multidisciplinary Institute of Biological Research-San Luis, CCT-San Luis, CONICET-National University of San Luis, San Luis, 5700 San Luis, Argentina. Electronic address:

Cadmium (Cd) exposure has been associated with an increased risk of cardiovascular diseases. The diet is a modifiable source of protecting or damaging factors that may affect this risk. Herein we tested the hypothesis that a soybean-based diet (SBD) protects the vascular wall of the aorta against Cd-induced pro-inflammatory and pro-apoptotic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2019.01.007DOI Listing

A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential.

Authors:
C Michael White

J Clin Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA.

Cannabidiol (CBD) is a highly touted product for many different disorders among the lay press. Numerous CBD products are available, ranging from a US Food and Drug Administration (FDA)-approved product called Epidiolex to products created for medical marijuana dispensaries and products sold in smoke shops, convenience stores, and over the Internet. The legal status of the non-FDA-approved products differs depending on the source of the CBD and the state, while the consistency and quality of the non-FDA-approved products vary markedly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.1387DOI Listing
February 2019
1 Read

A cumulative meta-analysis of endoscopic papillary balloon dilation versus endoscopic sphincterotomy for removal of common bile duct stones.

Endoscopy 2019 Feb 6. Epub 2019 Feb 6.

Endoscopy Unit, Department of Surgery, Ospedale Niguarda Ca Granda, Milan, Italy.

Background:  Endoscopic papillary balloon dilation (EPBD) was introduced to overcome the risk of adverse events associated with endoscopic sphincterotomy in the removal of common bile duct (CBD) stones. We performed a meta-analysis of randomized controlled trials (RCTs) comparing efficacy and safety of EPBD vs. endoscopic sphincterotomy, focusing on stone size, balloon diameter, and balloon dilation time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0818-3638DOI Listing
February 2019
3 Reads

Efficacy and Safety of a Weekly Cyclophosphamide-Bortezomib-Dexamethasone Regimen as Induction Therapy Prior to Autologous Stem Cell Transplantation in Japanese Patients with Newly Diagnosed Multiple Myeloma: A Phase 2 Multicenter Trial.

Acta Haematol 2019 Feb 6;141(2):111-118. Epub 2019 Feb 6.

Department of Medical Oncology, Ibaraki Prefectural Central Hospital, Kasama,

We assessed the efficacy and safety of weekly cyclophosphamide-bortezomib-dexamethasone (CBD) induction prior to autologous stem cell transplantation (ASCT) in newly diagnosed Japanese patients with multiple myeloma (MM). This regimen consisted of four 28-day cycles of once-weekly oral cyclophosphamide (300 mg/m2), subcutaneous bortezomib (1.3 mg/m2), and oral dexamethasone (40 mg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495338DOI Listing
February 2019
1 Read

Enzymatic Modification of N-Terminal Proline Residues Using Phenol Derivatives.

J Am Chem Soc 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry , University of California , Berkeley , California 94720 , United States.

A convenient enzymatic strategy is reported for the modification of proline residues in the N-terminal positions of proteins. Using a tyrosinase enzyme isolated from Agaricus bisporus (abTYR), phenols and catechols are oxidized to highly reactive o-quinone intermediates that then couple to N-terminal proline residues in high yield. Key advantages of this bioconjugation method include (1) the use of air-stable precursors that can be prepared on large scale if needed, (2) mild reaction conditions, including low temperatures, (3) the targeting of native functional groups that can be introduced readily on most proteins, and (4) the use of molecular oxygen as the sole oxidant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.8b10845DOI Listing
February 2019
12.113 Impact Factor

Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation.

Mol Pharm 2019 Feb 5. Epub 2019 Feb 5.

Inserm , U1144 , Paris F-75006 , France.

The effect of cannabidiol (CBD), a high-affinity agonist of the transient receptor potential vanilloid-2 (TRPV2) channel, has been poorly investigated in human brain microvessel endothelial cells (BMEC) forming the blood-brain barrier (BBB). TRPV2 expression and its role on Ca cellular dynamics, trans-endothelial electrical resistance (TEER), cell viability and growth, migration, and tubulogenesis were evaluated in human primary cultures of BMEC (hPBMEC) or in the human cerebral microvessel endothelial hCMEC/D3 cell line. Abundant TRPV2 expression was measured in hCMEC/D3 and hPBMEC by qRT-PCR, Western blotting, nontargeted proteomics, and cellular immunofluorescence studies. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01252
Publisher Site
http://dx.doi.org/10.1021/acs.molpharmaceut.8b01252DOI Listing
February 2019
4 Reads

Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.

ACS Chem Biol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, College of Physicians and Surgeons , Columbia University , New York , NY , United States.

Cellular retinol-binding proteins (CRBPs) facilitate the uptake and intracellular transport of vitamin A. They integrate retinoid metabolism, playing an important role in regulating the synthesis of bioactive vitamin A metabolites. Thus, CRBPs constitute potential pharmacological targets to modulate cellular retinoid status that in turn may have applications in the treatment of certain immunological, metabolic, and ocular disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.8b01070DOI Listing
February 2019
1 Read
5.331 Impact Factor

Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation.

Int J Mol Sci 2019 Feb 4;20(3). Epub 2019 Feb 4.

Laboratory of Immunotherapy and Bone Marrow Transplantation, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research dedicated to medical cannabis and cannabinoids is limited. The influence of these treatments on hematologic reconstitution and on the development of graft versus host disease (GVHD) after bone marrow transplantation (BMT) is largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030668DOI Listing
February 2019

Corticobasal Syndrome: Neuroimaging and Neurophysiological Advances.

Eur J Neurol 2019 Feb 5. Epub 2019 Feb 5.

IRCCS Neuromed Institute, Pozzilli, IS.

Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood. The prototypical clinical phenotype of CBD is corticobasal syndrome (CBS). Important insights into the pathophysiological mechanisms underlying motor and higher cortical symptoms in CBS have been gained by using advanced neuroimaging and neurophysiological techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.13928DOI Listing
February 2019

Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification.

Cancers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

School of Medicine, Institute of Medical Sciences, Örebro University, SE-70182 Örebro, Sweden.

In order to find out the most valuable biomarkers and pathways for diagnosis, therapy and prognosis in colorectal cancer (CRC) we have collected the published CRC biomarkers and established a CRC biomarker database (CBD: http://sysbio.suda.edu. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020172DOI Listing
February 2019

Facts and conjectures on calmodulin and its cousin proteins, parvalbumin and troponin C.

Biochim Biophys Acta Mol Cell Res 2019 Feb 1. Epub 2019 Feb 1.

Laboratoire d'Excellence Medalis, Université de Strasbourg, BSC CNRS UMR 7242, F-67412 Illkirch Cedex France.

This review aims at giving a rational frame to understand the diversity of EF hand containing calcium binding proteins and their roles, with special focus on three members of this huge protein family, namely calmodulin, troponin C and parvalbumin. We propose that these proteins are members of structured macromolecular complexes, termed calcisomes, which constitute building devices allowing treatment of information within eukaryotic cells and namely calcium signals encoding and decoding, as well as control of cytosolic calcium levels in resting cells. Calmodulin is ubiquitous, present in all eukaryotic cells, and pleiotropic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2019.01.014DOI Listing
February 2019

Novel Approaches for Treating Pain in Children.

Authors:
William Splinter

Curr Oncol Rep 2019 Feb 4;21(2):11. Epub 2019 Feb 4.

Palliative Medicine, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada.

Purpose Of Review: Good pain management in children, especially those at end of life, is a crucial component of palliative medicine. The current review assesses some of the new and/or innovative ways to manage pain in children. The article focuses on some recent medications/pharmaceutical options such as cannabinoids and also innovative ways to administer medication to children, such as intranasal and inhalation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11912-019-0766-6DOI Listing
February 2019
1 Read

Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol.

Front Oncol 2018 18;8:643. Epub 2019 Jan 18.

Department of Pathology, Santa Casa de São Paulo, São Paulo, Brazil.

We describe two patients with a confirmed diagnosis of high-grade gliomas (grades III/IV), both presenting with O6-methylguanine-DNA methyltransferase (MGMT) methylated and isocitrate dehydrogenase (IDH-1) mutated who, after subtotal resection, were submitted to chemoradiation and followed by PCV, a multiple drug regimen (procarbazine, lomustine, and vincristine) associated with cannabidiol (CBD). Both patients presented with satisfactory clinical and imaging responses at periodic evaluations. Immediately after chemoradiation therapy, one of the patients presented with an exacerbated and precocious pseudoprogression (PSD) assessed by magnetic resonance imaging (MRI), which was resolved in a short period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2018.00643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345719PMC
January 2019

Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.

Oncotarget 2019 Jan 1;10(1):45-59. Epub 2019 Jan 1.

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Neuroblastoma (NBL) is one of the most common childhood cancers that originate from the immature nerve cells of the sympathetic system. Studies with NBL cancers have also shown that miRNAs are dysregulated and may play a critical role in pathogenesis. Cannabidiol (CBD) is a non-psychoactive compound found in marijuana which has been previously shown by our laboratory and others to induce apoptosis in cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343753PMC
January 2019

Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome.

J Neurol Sci 2019 Jan 29;398:142-147. Epub 2019 Jan 29.

1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece.

Background: Corticobasal syndrome (CBS) can harbor diverse pathologies, such as corticobasal degeneration (CBD) and Alzheimer's disease (AD). CSF biochemical analysis in CBS patients can confidently distinguish between an AD (CBS-AD) and a non-AD (CBS-nAD) pathology.

Objective: We utilized classical CSF biomarkers to make a distinction between the two groups and examine their clinical, neuropsychological, neuropsychiatric and imaging differences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.01.046DOI Listing
January 2019
1 Read

A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety.

Curr Oncol Rep 2019 Feb 1;21(1):10. Epub 2019 Feb 1.

Park Nicollet Oncology Research, HealthPartners Institute, Frauenshuh Cancer Center, 3800 Park Nicollet Blvd, Minneapolis, MN, 55416, USA.

Purpose Of Review: As the legalization of medical cannabis continues across the USA, oncology care providers will be increasingly asked to provide recommendations regarding its use in the cancer setting. In this article, we review recent literature that analyzes cannabis use specifically in patients with cancer and provide an accessible guide for clinicians, researchers, and patients.

Recent Findings: We aimed to answer questions about the availability of cannabis in the USA, the trials supporting its use in the cancer setting, and the important factors to consider related to safety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11912-019-0757-7DOI Listing
February 2019

A stoichiometric CdS interlayer for the photovoltaic performance enhancement of quantum-dot sensitized solar cells.

Phys Chem Chem Phys 2019 Feb;21(7):3970-3975

Center for Advanced Optoelectronic Functional Materials Research, and Key Laboratory of UV-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, 5268 Renmin Street, Changchun, 130024, China.

The CdS interlayer plays an important role as the seed layer and energy barrier in photovoltaic performance enhancement of CdSe quantum-dot sensitized solar cells (QDSCs). However, the CdS (CdS-CBD) interlayer is generally synthesized by the chemical bath deposition method (CBD) and suffers from excessive Cd2+ due to the poor controllability of interfacial chemical reactions. Here, we employed a sol-gel method to prepare a CdS interlayer (CdS-SG) with a stoichiometric ratio of Cd2+ to S2- on a TiO2 mesoporous photoanode and then fabricated CdSe QDSCs. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C8CP06426A
Publisher Site
http://dx.doi.org/10.1039/c8cp06426aDOI Listing
February 2019
6 Reads

Is cannabidiol the ideal drug to treat non-motor Parkinson's disease symptoms?

Eur Arch Psychiatry Clin Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits, and psychiatric disorders such as psychosis, depression, and anxiety. The pharmacological treatment for these symptoms is limited in efficacy and induce significant adverse reactions, highlighting the need for better treatment options. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00406-019-00982-6DOI Listing
January 2019

How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review.

Eur Arch Psychiatry Clin Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Cannabinoid Research and Treatment Group, Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nußbaumstr. 7, 80336, Munich, Germany.

We conducted a review of systematic reviews (SRs) and randomized-controlled trials (RCTs) to analyze efficacy and safety of cannabis-based medication in patients with mental disorders. Five data bases were systematically searched (2006-August 2018); 4 SRs (of 11 RCTs) and 14 RCTs (1629 participants) were included. Diagnoses were: dementia, cannabis and opioid dependence, psychoses/schizophrenia, general social anxiety, posttraumatic stress disorder, anorexia nervosa, attention-deficit hyperactivity disorder, and Tourette`s disorder. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00406-019-00984-4
Publisher Site
http://dx.doi.org/10.1007/s00406-019-00984-4DOI Listing
January 2019
4 Reads

Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer.

J Pancreat Cancer 2019 25;5(1):1-7. Epub 2019 Jan 25.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Australia.

Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes. The aim of this review is to determine the potentially utility of cannabinoids in the treatment of pancreatic cancer. A literature review focused on the biological effects of cannabinoids in cancer treatment, with a focus on pancreatic cancer, was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/pancan.2018.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352507PMC
January 2019

Galenic Preparations of Therapeutic Differ in Cannabinoids Concentration: A Quantitative Analysis of Variability and Possible Clinical Implications.

Front Pharmacol 2018 17;9:1543. Epub 2019 Jan 17.

Section of Pharmacology and Toxicology, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Magistral preparations of therapeutic cannabis are extracted from standardized products imported from Holland or from the Florence Military Pharmaceutical Chemical Works, but extraction protocols differ among galenic laboratories. This study assessed the inter-laboratory variability in concentrations of cannabidiol (CBD), cannabinol (CBN), tetrahydrocannabinol (THC), and tetrahydrocannabinolic acid (THCA) among different magistral oil preparations. 219 samples of Bediol, Bedrobinol, Bedrolite or FM-2 70 or 100 mg/ml in oil were collected from 3 laboratories. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fphar.2018.01543
Publisher Site
http://dx.doi.org/10.3389/fphar.2018.01543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344428PMC
January 2019
3 Reads

Outcomes of endoscopic sphincterotomy open choledochotomy for common bile duct stones.

World J Gastroenterol 2019 Jan;25(4):485-497

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.

Background: Endoscopic sphincterotomy (EST) for the management of common bile duct stones (CBDS) is used increasingly widely because it is a minimally invasive procedure. However, some clinical practitioners argued that EST may be complicated by post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and accompanied by a higher recurrence of CBDS than open choledochotomy (OCT). Whether any differences in outcomes exist between these two approaches for treating CBDS has not been thoroughly elucidated to date. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v25.i4.485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350168PMC
January 2019

FDG-PET patterns associated with underlying pathology in corticobasal syndrome.

Neurology 2019 Jan 30. Epub 2019 Jan 30.

From the Departments of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health (M.P., F.N.) and Health Sciences (S.M.), University of Genoa; IRCCS Ospedale Policlinico San Martino (M.P., S.M., F.N.), Genoa, Italy; Cognitive Neuroscience Division, Department of Neurology (E.D.H.), Gertrude H. Sergievsky Center, New York; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.H., W.C.K.), Columbia University Medical Center, New York, NY; Department of Neurology (S.S.), UCSF Memory and Aging Center, UCSF, San Francisco, CA; Department of Pathology and Laboratory Medicine (S.S., B.G.), Indiana University School of Medicine, Indianapolis; Nuclear Medicine Unit (S.M.), IRCCS AOU San Martino, IST, Genoa, Italy; Behavioral Neurology Unit (E.M.W.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Psychiatry and Behavioral Sciences & Cognitive Neurology/Alzheimer's Disease Research Center (J.G.), Feinberg School of Medicine and Department of Psychology, Northwestern University; and Brain Injury Research, Cognitive Neuroscience Lab, Think and Speak Lab (J.G.), Shirley Ryan AbilityLab, Chicago, IL.

Objective: To evaluate brain Fluorodeoxyglucose PET (FDG-PET) differences among patients with a clinical diagnosis of corticobasal syndrome (CBS) and distinct underling primary pathologies.

Methods: We studied 29 patients with a diagnosis of CBS who underwent FDG-PET scan and postmortem neuropathologic examination. Patients were divided into subgroups on the basis of primary pathologic diagnosis: CBS-corticobasal degeneration (CBS-CBD) (14 patients), CBS-Alzheimer disease (CBS-AD) (10 patients), and CBS-progressive supranuclear palsy (CBS-PSP) (5 patients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007038DOI Listing
January 2019

Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review.

Alcohol Clin Exp Res 2019 Jan 30. Epub 2019 Jan 30.

Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University & St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.

There is substantial interest in the therapeutic potential of cannabidiol (CBD), a nonpsychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a candidate pharmacotherapy for alcohol use disorder (AUD). Using a comprehensive search strategy, 303 unique potential articles were identified and 12 ultimately met criteria for inclusion (8 using rodent models, 3 using healthy adult volunteers, and 1 using cell culture). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.13964DOI Listing
January 2019
1 Read

Decarbonylation: a metabolic pathway of cannabidiol in humans.

Drug Test Anal 2019 Jan 30. Epub 2019 Jan 30.

Institute of Forensic Medicine, Forensic Toxicology, University Bonn, Stiftsplatz 12, 53111, Bonn, Germany.

Cannabidiol (CBD) is a non-psychoactive cannabinoid, which is of growing medical interest. Previous studies on the metabolism of CBD showed mainly the formation of hydroxylated or oxidized derivatives, of carboxylic acids or modifications of the aliphatic side chain. Using incubation of CBD with hepatic microsomes of mice, the formation of carbon monoxide was reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dta.2572DOI Listing
January 2019

Anti-Tumor Activity of Cembranoid-Type Diterpenes Isolated from Nicotiana tabacum L.

Biomolecules 2019 Jan 28;9(2). Epub 2019 Jan 28.

Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.

Recently, the incidence of hepatocellular carcinoma has increased worldwide. Cembranoid-type diterpenes (CBDs) from tobacco exhibit good antimicrobial, antitumor, and neuroprotective activities. Therefore, in this study, we isolated CBDs from L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9020045DOI Listing
January 2019
1 Read

Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model.

J Surg Res 2019 Mar 30;235:210-215. Epub 2018 Oct 30.

Department of Oral Biology/Dental College of Georgia, Augusta University Medical Center, Augusta, Georgia; Division of Plastic Surgery/Medical College of Georgia, Department of Surgery, Augusta University Medical Center, Augusta, Georgia.

Background: Malignant melanoma is a complex malignancy with significant morbidity and mortality. The incidence continues to rise, and despite advances in treatment, the prognosis is poor. Thus, it is necessary to develop novel strategies to treat this aggressive cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804183062
Publisher Site
http://dx.doi.org/10.1016/j.jss.2018.08.055DOI Listing
March 2019
8 Reads

US Veterinarians' Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions.

Front Vet Sci 2018 10;5:338. Epub 2019 Jan 10.

Veterinary Information Network, Davis, CA, United States.

Due to the myriad of laws concerning cannabis, there is little empirical research regarding the veterinary use of cannabidiol (CBD). This study used the Veterinary Information Network (VIN) to gauge US veterinarians' knowledge level, views and experiences related to the use of in the medical treatment of dogs. Participants ( = 2130) completed an anonymous, online survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fvets.2018.00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338022PMC
January 2019
2 Reads