7,333 results match your criteria CBD Lipid Signaling [Journal]


THC and CBD Produce Divergent Effects on Perception and Panic Behaviours via Distinct Cortical Molecular Pathways.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 2:110029. Epub 2020 Jul 2.

Addiction Research Group, University of Western Ontario, London, Ontario, N6A 5C1, Canada; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, N6A 5C1, Canada; Department of Psychiatry. Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada. Electronic address:

Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs. CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays antipsychotic and anxiolytic properties. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110029DOI Listing

Development of food grade 3D printable ink based on pectin containing cannabidiol/cyclodextrin inclusion complexes.

Drug Dev Ind Pharm 2020 Jul 3:1-32. Epub 2020 Jul 3.

Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.

In the current study a 3D-printable system was developed, based on natural, food-grade and non-toxic materials that may be used as a platform technology to host cannabinoids, and more specifically CBD for medicinal purposes. Pectin and honey were combined towards the fabrication of 3D printable inks that form solid structures upon drying. This model food-grade 3D-printed system was evaluated as a host matrix for the incorporation of CBD, in the form of inclusion complexes with β-cyclodextrins. Read More

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http://dx.doi.org/10.1080/03639045.2020.1791168DOI Listing

Controlling Binder Adhesion to Impact Electrode Mesostructure and Transport.

ACS Appl Mater Interfaces 2020 Jul 2. Epub 2020 Jul 2.

The complex three-phase composition of lithium-ion battery electrodes - containing an ion-conducting pore phase, a nanoporous electron-conducting carbon binder domain (CBD) phase, and an active material (AM) phase - provides several avenues of mesostructural engineering to enhance battery performance. We demonstrate a promising strategy for engineering electrode mesostructures by controlling the strength of adhesion between the AM and CBD phases. Using high-fidelity, physics-based colloidal and granular dynamics simulations, we predict that this strategy can provide significant control over electrochemical transport-relevant properties such as ionic conductivity, electronic conductivity, and available AM surface area. Read More

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http://dx.doi.org/10.1021/acsami.0c08251DOI Listing

Interactions between cannabidiol and Δ -tetrahydrocannabinol in modulating seizure susceptibility and survival in a mousae model of Dravet syndrome.

Br J Pharmacol 2020 Jul 1. Epub 2020 Jul 1.

Brain and Mind Centre, The University of Sydney, Sydney, Australia.

Background And Purpose: Extracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet syndrome. These extracts typically contain cannabidiol (CBD), a phytocannabinoid with well-documented anticonvulsant effects, but may also contain Δ -tetrahydrocannabinol (Δ -THC). It is unclear whether the presence of Δ -THC modulates the anticonvulsant efficacy of CBD. Read More

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http://dx.doi.org/10.1111/bph.15181DOI Listing

Hemobilia as a Complication of Transhepatic Percutaneous Biliary Drainage: a Rare Indication for Laparoscopic Common Bile Duct Exploration.

J Gastrointest Surg 2020 Jun 30. Epub 2020 Jun 30.

General Surgery Division, NYU Langone Health - Bellevue Hospital, 550 1st Avenue, New York, NY, |10016, USA.

Background: Hemobilia is the presence of blood in the biliary tree and is a frequent complication after percutaneous transhepatic biliary drainage (PTBD). Most of these episodes are self-limited; nevertheless, in less than 5% of cases, hemobilia is clinically significant, requiring an intervention (hepatic artery embolization, stenting, or percutaneous thrombin injection). Adequate treatment requires control of hemorrhage and restoration of bile flow. Read More

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http://dx.doi.org/10.1007/s11605-020-04664-wDOI Listing

The Effectiveness of Flower for Immediate Relief from Symptoms of Depression.

Yale J Biol Med 2020 06 29;93(2):251-264. Epub 2020 Jun 29.

Department of Psychology, University of New Mexico, Albuquerque, NM.

: Scientific research on how consumption of whole, natural flower affects low mood and behavioral motivations more generally is largely nonexistent, and few studies to date have measured how common and commercially available flower used may affect the experience of "depression" in real-time. : We observed 1,819 people who completed 5,876 cannabis self-administration sessions using the ReleafApp™ between 06/07/2016 and 07/08/2019, with the goal of measuring real-time effects of consuming flower for treating symptoms of depression. Results: On average, 95. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309674PMC

Dopamine mediates life-history responses to food abundance in .

Proc Biol Sci 2020 Jul 1;287(1930):20201069. Epub 2020 Jul 1.

Centre for Biodiversity Dynamics (CBD), Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 5, 7491 Trondheim, Norway.

Expression of adaptive reaction norms of life-history traits to spatio-temporal variation in food availability is crucial for individual fitness. Yet little is known about the neural signalling mechanisms underlying these reaction norms. Previous studies suggest a role for the dopamine system in regulating behavioural and morphological responses to food across a wide range of taxa. Read More

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http://dx.doi.org/10.1098/rspb.2020.1069DOI Listing

Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.

Sleep Med Rev 2020 May 16;53:101339. Epub 2020 May 16.

The University of Sydney, Faculty of Science, School of Psychology, Sydney, New South Wales, Australia; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Camperdown, New South Wales, Australia; The University of Sydney, Brain and Mind Centre, Sydney, New South Wales, Australia. Electronic address:

Cannabinoids, including the two main phytocannabinoids Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders. THC and CBD are known to interact with the endocannabinoid and other neurochemical systems to influence anxiety, mood, autonomic function, and circadian sleep/wake cycle. However, their therapeutic efficacy and safety as treatments for sleep disorders are unclear. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101339DOI Listing

Long-term loss in extent and current protection of terrestrial ecosystem diversity in the temperate and tropical Americas.

PLoS One 2020 30;15(6):e0234960. Epub 2020 Jun 30.

NatureServe, Arlington, VA, United States of America.

Documenting changes in ecosystem extent and protection is essential to understanding status of biodiversity and related ecosystem services and have direct applications to measuring Essential Biodiversity Variables, Targets under the Convention on Biological Diversity (CBD), and IUCN Red List of Ecosystems. We developed both potential and current distribution maps of terrestrial ecosystem types for the temperate and tropical Americas; with "potential" estimating where a type would likely occur today had there not been prior land conversion for modern land uses. We utilized a hierarchical classification to describe and map natural ecosystem types at six levels of thematic detail, with lower thematic levels defining more units each with narrower floristic range than upper levels. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234960PLOS

The impact of foetal restrictions on mode of delivery in women with inherited bleeding disorders.

Eur J Haematol 2020 Jun 30. Epub 2020 Jun 30.

RCSI Department of Obstetrics and Gynaecology, Coombe Women and Infants University Hospital, Dublin 8, Dublin, Ireland.

Objectives: Management of pregnancy in women with congenital bleeding disorders (CBD) is challenging and requires understanding of risks conferred to both the mother and foetus. Some elements of labour management are considered to increase the risk of neonatal bleeding and are not recommended for neonates at risk of a significant bleeding disorder. The impact of these restrictions on obstetric outcomes in women with CBD is unknown. Read More

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http://dx.doi.org/10.1111/ejh.13481DOI Listing

Antioxidants help favorably regulate the kinetics of lipid peroxidation, polyunsaturated fatty acids degradation and acidic cannabinoids decarboxylation in hempseed oil.

Sci Rep 2020 Jun 29;10(1):10567. Epub 2020 Jun 29.

Food, Nutrition, and Health, Faculty of Land & Food Systems. The University of British Columbia, 2205 East Mall., Vancouver, BC, V6T 1Z4, Canada.

The seed of the hemp plant (Cannabis sativa L.) has been revered as a nutritional resource in Old World Cultures. This has been confirmed by contemporary science wherein hempseed oil (HSO) was found to exhibit a desirable ratio of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) considered optimal for human nutrition. Read More

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http://dx.doi.org/10.1038/s41598-020-67267-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324387PMC

Use of Cannabis for Agitation in Patients With Dementia.

Sr Care Pharm 2020 Jul;35(7):312-317

Studies have reported changes in the endocannabinoid system in the brain of patients with Alzheimer's disease (AD), playing a role in the pathophysiology of AD. Cannabinoids have been shown to have neuroprotective properties, reduce neuroinflammation, and enhance neurogenesis. Evidence suggests that the utilization of marijuana products containing both tetrahydrocannabinol (THC) and cannabidiol (CBD) or CBD alone have been effective and safe for use in older people with agitation associated with dementia. Read More

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http://dx.doi.org/10.4140/TCP.n.2020.312.DOI Listing

Pharmacological analysis of Cannabis sativa: A potent herbal plant.

Mini Rev Med Chem 2020 Jun 27. Epub 2020 Jun 27.

Department of Chemistry, Faculty of Science, King Khalid University, Abha, 61413. Saudi Arabia.

Genus Cannabis belong to family Cannabaceae and is traditionally used as medicinal plant against many diseases notably asthma, malaria, treatment of skin diseases, diabetes and headache. The plant Cannabis sativa L. is flowering and an annual herbaceous plant located to eastern Asia but now of cosmopolitan distribution due to extensive cultivation. Read More

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http://dx.doi.org/10.2174/1389557520666200628031644DOI Listing

Cannabis knowledge and implications for health: Considerations regarding the legalization of non-medical cannabis.

Med Sci Law 2020 Jun 29:25802420934255. Epub 2020 Jun 29.

Department of Psychology, University of Bath, United Kingdom.

Cannabis contains over a hundred of different cannabinoids, of which Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well studied. The use of high-potency cannabis, containing high concentrations of THC and low concentrations of CBD, has been linked to adverse health outcomes, particularly for adolescents and young adults. Recently, an increase in cannabis potency has been observed in jurisdictions that legalized the sale of cannabis for non-medical purposes. Read More

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http://dx.doi.org/10.1177/0025802420934255DOI Listing

The role of cannabidiol oil in schizophrenia treatment. a systematic review and meta-analysis.

Psychiatry Res 2020 Jun 22;291:113246. Epub 2020 Jun 22.

Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece. Electronic address:

The purpose of the present meta-analysis was to assess the efficacy of cannabidiol (CBD) oil in patients with schizophrenia. A search was conducted in EMBASE, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) up to April 24th, 2020. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113246DOI Listing

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.

Neurobiol Dis 2020 Jun 26;143:104994. Epub 2020 Jun 26.

Instituto Maimónides de Investigación Biomédica de Córdoba, Spain; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Electronic address:

Multiple Sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes in the spinal cord and the brain. Natural and synthetic cannabinoids such as VCE-004.8 have been studied in preclinical models of MS and represent promising candidates for drug development. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.104994DOI Listing

Incidence and risk factors for postoperative common bile duct stones in patients undergoing endoscopic extraction and subsequent cholecystectomy.

Gastrointest Endosc 2020 Jun 26. Epub 2020 Jun 26.

Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.

Background And Aims: In patients who undergo cholecystectomy after endoscopic common bile duct (CBD) stone extraction, CBD stones found postoperatively could be problematic. This study aimed to investigate the incidence and risk factors of postoperative CBD stones after cholecystectomy.

Methods: A total of 278 patients (mean age, 59. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.060DOI Listing

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol.

Authors:
Katarina Černe

Arh Hig Rada Toksikol 2020 Mar;71(1):1-11

Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. Read More

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http://dx.doi.org/10.2478/aiht-2020-71-3301DOI Listing

THC and CBD blood and brain concentrations following daily administration to adolescent primates.

Drug Alcohol Depend 2020 Jun 18;213:108129. Epub 2020 Jun 18.

Laboratory of Addiction Neurobiology, McLean Hospital, 115 Mill St, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA. Electronic address:

Background: Cannabis availability with high concentrations of Δ-9-tetrahydrocannabinol (THC) and a range of THC to cannabidiol (CBD) ratios has increased in parallel with a rise in daily cannabis consumption by adolescents. Unanswered questions in adolescents include: 1) whether THC blood concentrations and THC metabolites remain stable or change with prolonged daily dosing, 2) whether CBD modulates THC pharmacokinetic properties and alters THC accumulation in brain, 3) whether blood THC levels reflect brain concentrations.

Methods: In adolescent squirrel monkeys (Saimiri boliviensis), we determined whether a four-month regimen of daily THC (1 mg/kg) or CBD (3 mg/kg) + THC (1 mg/kg) administration (IM) affects THC, THC metabolites, and CBD concentrations in blood or brain. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108129DOI Listing

Cannabidiol efficacy independent of clobazam: meta-analysis of four randomized-controlled trials.

Acta Neurol Scand 2020 Jun 26. Epub 2020 Jun 26.

GW Research Ltd, Cambridge, UK.

Objective: The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four large randomized controlled trials, two in Lennox-Gastaut syndrome and two in Dravet syndrome.

Methods: Each trial of CBD (Epidiolex® in the US; Epidyolex® in the EU; 10 and 20 mg/kg/day) was evaluated by CLB use. The treatment ratio was analyzed using negative binomial regression for changes in seizure frequency and logistic regression for the 50% responder rate, where the principle analysis combined both indications and CBD doses in a stratified meta-analysis. Read More

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http://dx.doi.org/10.1111/ane.13305DOI Listing

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Drug Metab Dispos 2020 Jun 25. Epub 2020 Jun 25.

Department of Pharmaceutics, University of Washington, United States

Cannabis is used for both recreational and medicinal purposes. The most abundant constituents are the cannabinoids - cannabidiol (CBD, non-psychoactive) and (-)--Δ⁹-tetrahydrocannabinol (THC, psychoactive). Both have been reported to reversibly inhibit or inactivate cytochrome P450 (CYP) enzymes. Read More

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http://dx.doi.org/10.1124/dmd.120.000073DOI Listing

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies.

Brain Sci 2020 Jun 23;10(6). Epub 2020 Jun 23.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the context of autoimmune encephalitis with antineuronal antibodies, such as anti-glycine receptor (anti-GlyR) antibodies, which are typically associated with Stiff-Person spectrum syndrome, or progressive encephalomyelitis with rigidity and myoclonus. Overlaps between neurodegenerative and immunological mechanisms have been recently suggested in anti-IgLON5 disease. Read More

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http://dx.doi.org/10.3390/brainsci10060399DOI Listing

Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review.

Medicina (Kaunas) 2020 Jun 23;56(6). Epub 2020 Jun 23.

Clinical Pharmacology Department, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias (HUGTiP-IGTP), 08916 Badalona, Spain.

Background And Objective: Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. From a therapeutic perspective, oral cannabis containing Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is a promising route of administration but there is still little information about its pharmacokinetics (PK) effects in humans. Read More

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http://dx.doi.org/10.3390/medicina56060309DOI Listing

Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish.

Epilepsy Behav 2020 Jun 22;110:107152. Epub 2020 Jun 22.

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States of America. Electronic address:

Current antiepileptic drugs (AEDs) are undesirable for many reasons including the inability to reduce seizures in certain types of epilepsy, such as Dravet syndrome (DS) where in one-third of patients does not respond to current AEDs, and severe adverse effects that are frequently experienced by patients. Epidiolex, a cannabidiol (CBD)-based drug, was recently approved for treatment of DS. While Epidiolex shows great promise in reducing seizures in patients with DS, it is used in conjunction with other AEDs and can cause liver toxicity. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107152DOI Listing

Adaptation of Complete Denture Base Fabricated by Conventional, Milling, and 3-D Printing Techniques: An Study.

J Contemp Dent Pract 2020 Apr 1;21(4):367-371. Epub 2020 Apr 1.

Research Center, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.

Aim: The aim of this study was to compare the adaptation of complete denture base (CDB) manufactured by three different techniques: conventional, milling, and three-dimensional (3-D) printing.

Materials And Methods: A master cast was duplicated to create 60 gypsum casts. Twenty casts ( = 20) were attributed to each group. Read More

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Access and Benefit Sharing Under the Nagoya Protocol-? Six Latin American Case Studies Assessing Opportunities and Risk.

Front Pharmacol 2020 8;11:765. Epub 2020 Jun 8.

Asociación Nacional de Conservación de la Naturaleza (National Association for the Conservation of Nature), Cd. de Panama City, Panamá.

Background: Global challenges related to access and benefit sharing (ABS) of biological resources have become a key concern in the area of research on herbal medicines, ethnopharmacology, drug discovery, and the development of other high value products for which Intellectual Property protection can be secured. While the Convention on Biological Diversity (CBD, Rio 1992) has been recognized as a huge step forward, the implementation of the Nagoya Protocol (NP) and of new forms of collaboration often remain unresolved, especially in the context of "the fair and equitable sharing of benefits arising from the utilization of genetic resources" (Convention on Biological Diversity, 2011). The vision and the specific implementation of this international treaty vary from country to country, which poses additional challenges. Read More

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http://dx.doi.org/10.3389/fphar.2020.00765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294742PMC

Collagen particle with collagen-binding bone morphogenetic protein-2 promotes vertebral laminar regeneration in infant rabbits.

Biomed Mater 2020 Jun 24. Epub 2020 Jun 24.

Chinese Academy of Sciences - Institute of Genetics and Developmental Biology, No 1 West Beichen Road, Chaoyang District, Beijing, 100101, Beijing, Beijing, CHINA.

The vertebral laminar defects caused by severe spina bifida occulta, spinal fracture, or bone tuberculosis require surgical treatment. The reconstruction of vertebral laminar defects remains challenging, especially in children. In this study, we created an animal model of vertebral laminar defects in newly weaned rabbits to evaluate the therapeutic effect of bovine bone collagen particle (BBCP) that combined with bone morphogenetic protein-2 with collagen binding domain (CBD-BMP-2). Read More

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http://dx.doi.org/10.1088/1748-605X/ab9fceDOI Listing
June 2020
3.697 Impact Factor

Impact of Urban Heat Island on Meteorology and Air Quality at Microenvironment.

J Air Waste Manag Assoc 2020 Jun 24. Epub 2020 Jun 24.

Department Urban and Environmental Sociology, Helmholtz Centre for Environmental Research-UFZ ,Leipzig, Germany.

This study analyses the air pollution characteristics and their relation to meteorological conditions in Chennai, India. Meteorological conditions were the primary factor determining variations in daily average pollutant concentrations. The influence of urban infrastructure on meteorology is an important prediction on air quality. Read More

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http://dx.doi.org/10.1080/10962247.2020.1783390DOI Listing

Chronic cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus: epigenetic implications for psychiatric disease.

Environ Mol Mutagen 2020 Jun 24. Epub 2020 Jun 24.

Department of Animal Science, University of Minnesota.

Cannabidiol (CBD) is the primary non-psychoactive compound found in cannabis (Cannabis sativa) and an increasingly popular dietary supplement as a result of widespread availability of CBD-containing products. CBD is FDA-approved for the treatment of epilepsy and exhibits anxiolytic, antipsychotic, prosocial, and other behavioral effects in animal and human studies, however, the underlying mechanisms governing these phenotypes are still being elucidated. The epigenome, particularly DNA methylation, is responsive to environmental input and can govern persistent patterns of gene regulation affecting phenotype across the life course. Read More

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http://dx.doi.org/10.1002/em.22396DOI Listing

Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.

Neuropharmacology 2020 Jun 20:108156. Epub 2020 Jun 20.

Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil. Electronic address:

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence supporting the hypothesis that the PI3Kγ signaling pathway may mediate the powerful anticonvulsant properties associated with the cannabinoidergic system. This work aims to investigate if the anticonvulsant and neuroprotective effects of cannabidiol (CBD) are mediated by PI3Kγ. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108156DOI Listing

Characterization of By-products from Commercial Cannabidiol Production.

J Agric Food Chem 2020 Jun 23. Epub 2020 Jun 23.

The chemical compositions of by-products from commercial cannabidiol (CBD) extraction were characterized and quantitated employing gas chromatography mass spectrometry (GC-MS) and gas chromatography flame-ionization detection (GC-FID). The four major by-products included an ethanol-wax suspension (WAX), terpenoid distillate (DIST-A), tar-like residue (TAR), and red resin (RES). The composition of WAX consisted of ~28 wt % n-alkanes and ~33-38 wt % cannabidiolic acid and CBD combined. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c03032DOI Listing

Aortic remodelling after thoracic endovascular aortic repair in acute and chronic type B aortic dissections.

Eur J Cardiothorac Surg 2020 Jun 23. Epub 2020 Jun 23.

Department of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Pennsylvania, PA, USA.

Objectives: Type B aortic dissections are routinely treated with thoracic endovascular aortic repair (TEVAR). The timing for TEVAR remains controversial and might have an impact on the remodelling capacity of the aorta. This study analyses and compares aortic remodelling in acute (ABD) and chronic (CBD) type B aortic dissections after TEVAR. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa118DOI Listing

Severe acute malnutrition treatment delivered by low-literate community health workers in South Sudan: A prospective cohort study.

J Glob Health 2020 Jun;10(1):010421

International Rescue Committee, New York, New York, USA.

Background: Community health worker (CHW)-delivered acute malnutrition treatment programs have been tested previously, but not with low-literate/-numerate cadres who operate in areas with the highest malnutrition burden and under-five mortality rates. The International Rescue Committee developed low-literacy-adapted tools and treatment protocol to enable low-literate/-numerate community-based distributors (CBD, the CHW cadre in South Sudan) to treat children for severe acute malnutrition (SAM) in their communities.

Methods: We conducted a prospective cohort study in March-September 2017, with 44 CBDs enrolling a total of 308 SAM children into treatment in their communities. Read More

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http://dx.doi.org/10.7189/jogh.10.010421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295452PMC

Chronic cannabidiol (CBD) treatment did not exhibit beneficial effects in 4-month-old male TAU58/2 transgenic mice.

Pharmacol Biochem Behav 2020 Jun 17:172970. Epub 2020 Jun 17.

School of Medicine, Western Sydney University, Campbelltown, Australia; Neuroscience Research Australia (NeuRA), Randwick, Australia. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, motor impairments, and accumulation of hallmark proteins, amyloid-beta (Aβ) and tau. Traditionally, transgenic mouse models for AD have focused on Aβ pathology, however, recently a number of tauopathy transgenic models have been developed, including the TAU58/2 transgenic model. Cannabidiol (CBD), a non-toxic constituent of the Cannabis sativa plant, has been shown to prevent and reverse cognitive deficits in Aβ transgenic mouse models of AD. Read More

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http://dx.doi.org/10.1016/j.pbb.2020.172970DOI Listing

Matching biodiversity indicators to policy needs.

Conserv Biol 2020 Jun 18. Epub 2020 Jun 18.

School of Life and Environmental Sciences, Centre for Integrative Ecology, Deakin University, Victoria, Australia.

Policy makers rely on biodiversity indicators to assess when, where and how nature is changing. Some indicators, however, respond more quickly to pressures than others, measuring short-term and potentially reversible change, while others capture permanent loss of biodiversity. These characteristics influence an indicator's suitability to perform predictive versus retrospective evaluation functions, but are rarely considered when developing or interpreting indicators. Read More

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http://dx.doi.org/10.1111/cobi.13575DOI Listing

Current application of cannabidiol (CBD) in the management and treatment of neurological disorders.

Neurol Sci 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Cannabidiol (CBD), which is nonintoxicating pharmacologically relevant constituents of Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative, anti-inflammatory, and neuroprotective effects. As the medicinal use of CBD is gaining popularity for treatment of various disorders, the recent flare-up of largely unproven and unregulated cannabis-based preparations on medical therapeutics may have its greatest impact in the field of neurology. Read More

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http://dx.doi.org/10.1007/s10072-020-04514-2DOI Listing

Plant derived versus synthetic cannabidiol: Wishes and commitment of epilepsy patients.

Seizure 2020 Jun 8;80:92-95. Epub 2020 Jun 8.

Department of Epileptology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; St Mauritius Therapieklinik, Strümper Straße 111, 40670 Meerbusch, Germany.

Purpose: A special component of cannabis, cannabidiol (CBD), is currently in the focus of epilepsy treatment and research. In this context, we investigated patients' expectations and preferences pertaining to plant-derived versus synthetic formulation of cannabidiol, as well as their willingness to get this treatment.

Methods: One hundred and four of 153 patients with different forms of epilepsy (54 % female, mean age 40 ± 16 yrs. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.012DOI Listing

Children and Youth Who Use Cannabis for Pain Relief: Benefits, Risks, and Perceptions.

Adolesc Health Med Ther 2020 21;11:53-61. Epub 2020 May 21.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

We provide up-to-date perspectives on the benefits and risks of medical cannabis for pain management in children and youth. To date, only two studies (a case report and a small observational study) have examined the effects of medical cannabis on pain in children and youth. No controlled trial has commented on long-term safety of medical cannabis. Read More

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http://dx.doi.org/10.2147/AHMT.S254264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247732PMC

Isolation, Purification, and Antimicrobial Characterization of Cannabidiolic Acid and Cannabidiol from L.

Biomolecules 2020 Jun 12;10(6). Epub 2020 Jun 12.

Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.

The emergence of multi-drug resistant bacteria such as methicillin-resistant (MRSA) causes a major threat to public health due to its limited therapeutic options. There is an urgent need for the development of new effective antimicrobial agents and alternative strategies that are effective against resistant bacteria. The parallel legalization of cannabis and its products has fueled research into its many therapeutic avenues in many countries around the world. Read More

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http://dx.doi.org/10.3390/biom10060900DOI Listing

Effectiveness of cannabidiol in a prospective cohort of children with drug-resistant epileptic encephalopathy in Argentina.

Seizure 2020 Jun 6;80:75-80. Epub 2020 Jun 6.

Department of Neurology, Hospital de Pediatría "Prof. Dr. Juan P Garrahan", Combate de los Pozos 1881, CP 1245, Buenos Aires, Argentina. Electronic address:

Objective: We report our preliminary findings regarding effectiveness, safety, and tolerability of cannabidiol (CBD) added to antiepileptic therapy in a cohort of children with drug-resistant epileptic encephalopathies (EEs) with a mean follow-up of 8.5 months (range, 3-12 months).

Methods: A prospective cohort study was designed with the aim of assessing the effectiveness, safety, and tolerability of the addition of CBD to standard antiseizure medications (ASMs) in children with drug-resistant EE enrolled at a single center (Neurology Department, Hospital de Pediatría "Juan P. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.005DOI Listing

Differentiating Full-Spectrum Hemp Extracts from CBD Isolates: Implications for Policy, Safety and Science.

J Diet Suppl 2020 Jun 16:1-10. Epub 2020 Jun 16.

Science, Regulation & Education, CV Sciences, Inc, San Diego, CA, USA.

The passage of the 2018 United States Agriculture Improvement Act removed industrial hemp, defined as L. containing less than 0.3% THC content by dry weight, from Schedule I of the Controlled Substances Act and made it an agricultural commodity. Read More

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http://dx.doi.org/10.1080/19390211.2020.1776806DOI Listing

Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches.

J Diet Suppl 2020 Jun 16:1-10. Epub 2020 Jun 16.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.

The proliferation in the last few years of cannabidiol (CBD)-containing products in the U.S. markets has been greatly accelerated by changes in the regulatory environment, and by perceptions of their health benefits and presumed safety. Read More

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http://dx.doi.org/10.1080/19390211.2020.1777244DOI Listing

Laparoendoscopic rendezvous versus ERCP followed by laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: a systemic review and meta-analysis.

Surg Endosc 2020 Jun 12. Epub 2020 Jun 12.

The First Clinical Medical College, Lanzhou University, Lanzhou, People's Republic of China.

Background: The ideal management for patients with cholecystocholedocholithiasis is still controversial. Laparoendoscopic rendezvous (LERV), combined with laparoscopy and endoscopy, is a novel and attractive technique. The aim of this research was to compare LERV with traditional two-stage management, preoperative ERCP and laparoscopic cholecystectomy (ERCP + LC), for treating patients with cholecystocholedocholithiasis. Read More

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http://dx.doi.org/10.1007/s00464-020-07698-yDOI Listing

Genetics of colour variation in wild versus cultured queen loach, Botia dario (Hamilton, 1822).

Genomics 2020 Jun 9. Epub 2020 Jun 9.

College of Fisheries, Central Agricultural University (Imphal), Lembucherra, Tripura 799210, India. Electronic address:

The Queen loach (Botia dario), an ornamental fish species having export potential, belongs to family Cobitidae of order Cypriniformes. The dull colouration in captive condition as compared to nature is a drawback in ornamental fisheries. We report the first comparative transcriptomic analysis of Cultured (CBD) and Natural (NBD) B. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.012DOI Listing

Synthetic Access to Cannabidiol and Analogs As Active Pharmaceutical Ingredients.

J Med Chem 2020 Jun 12. Epub 2020 Jun 12.

Cannabinoids have surely been one of the most widely self-administered drugs, other than caffeine. The US FDA recently approved one cannabinoid-based drug whose active pharmaceutical ingredient (API) is cannabidiol (CBD). The long history of individual use of cannabis for a wide range of conditions has sparked great interest in other uses of CBD, in ethical drugs and botanical supplements as well as in foods and non-prescription wellness products. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00095DOI Listing

Development and validation of LC-MS/MS method with QuEChERS clean-up for detecting cannabinoids in foods and dietary supplements.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2020 Jun 12:1-12. Epub 2020 Jun 12.

Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si, Republic of Korea.

a rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC) using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) clean-up for a variety of foods and dietary supplements (DS). QuEChERS is widely used in extraction or clean-up procedures to eliminate interference of matrices such as sugars, organic acids, lipids, and fatty acids. The samples were categorised into three types, and various pretreatment methods were compared for each type. Read More

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http://dx.doi.org/10.1080/19440049.2020.1769200DOI Listing

Effectiveness of endoscopic Doppler probe ultrasonography for identifying the source of colonic diverticular bleeding.

VideoGIE 2020 Jun 29;5(6):255-256. Epub 2020 Apr 29.

Division of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.vgie.2020.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278025PMC

Unraveling the Intoxicating and Therapeutic Effects of Cannabis Ingredients on Psychosis and Cognition.

Front Psychol 2020 14;11:833. Epub 2020 May 14.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Research evidence suggests a dose-response relationship for the association between cannabis use and risk of psychosis. Such relationship seems to reflect an increased risk of psychosis not only as a function of frequent cannabis use, but also of high-potency cannabis use in terms of concentration of Δ-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive component. This finding would be in line with the evidence that Δ9-THC administration induces transient psychosis-like symptoms in otherwise healthy individuals. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.00833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247841PMC

Long-term assessment of the cognitive effects of nabiximols in patients with multiple sclerosis: A pilot study.

Clin Neurol Neurosurg 2020 Jun 5;196:105990. Epub 2020 Jun 5.

Department of Neurology, S. Paolo Hospital, Via Genova 30, 17100, Savona, Italy. Electronic address:

Objective: Moderate to severe spasticity is commonly reported in Multiple Sclerosis (MS) and its management is still a challenge. Cannabinoids were recently suggested as add-on therapy for the treatment of spasticity and chronic pain in MS but there is no conclusive scientific evidence on their safety, especially on cognition and over long periods. The aim of this prospective pilot study was to assess the long-term effects of a tetrahydrocannabinol-cannabidiol (THC/CBD) oromucosal spray (Sativex®) on cognition, mood and anxiety. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105990DOI Listing

Considerations and Implications of Cannabidiol Use During Pregnancy.

Curr Pain Headache Rep 2020 Jun 10;24(7):38. Epub 2020 Jun 10.

Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

Purpose Of Review: Cannabis is a naturally occurring plant that is composed of over sixty phytocannabinoids, of which cannabidiol (CBD) has been recently identified as having therapeutic potential.

Recent Findings: Although not clearly understood in its mechanism of action, CBD contains potent anti-inflammatory, anti-hyperalgesia, and analgesic qualities now being further analyzed for its use in the treatment of a plethora of diseases. Related to its large safety profile and lack of psychoactive effects typically associated with cannabis and tetrahydrocannabinol (THC), CBD is being used more frequently for self-treatment of chronic pain, anxiety, and depression. Read More

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http://dx.doi.org/10.1007/s11916-020-00872-wDOI Listing