6,169 results match your criteria CBD Lipid Signaling [Journal]


Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5904-5911

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States.

Purpose: It has been known for nearly 50 years that cannabis and the psychoactive constituent Δ9-tetrahydrocannabinol (THC) reduce intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a major cause of blindness. THC likely acts via one of the known cannabinoid-related receptors (CB1, CB2, GPR18, GPR119, GPR55) but this has never been determined explicitly. Read More

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December 2018
1 Read

Chemical characterization of leaves, male and female flowers from spontaneous cannabis (Cannabis sativa var. spontanea) growing in Hungary.

Chem Biodivers 2018 Dec 13. Epub 2018 Dec 13.

University of Camerino, School of Pharmacy, Via Sant'Agostino 1, 62032, Camerino, ITALY.

Cannabis sativa var. spontanea is a spontaneous form of hemp with a low content of psychoactive cannabinoids and can be considered as a valuable source of other phytoconstituents to be used in nutraceuticals or for their health promoting properties. Chemical data on this hemp variety are rather scarce. Read More

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December 2018

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes.

EJNMMI Res 2018 Dec 13;8(1):110. Epub 2018 Dec 13.

Department of Nuclear Medicine and Molecular Imaging, Division of Nuclear Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage. The objective of this study was to classify patients with amyotrophic lateral sclerosis (ALS) and Parkinson plus syndromes (PP). To this end, different approaches were evaluated using generalized linear models and corresponding glucose metabolic brain patterns. Read More

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December 2018

Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.

J Altern Complement Med 2018 Dec 13. Epub 2018 Dec 13.

4 Department of Naturopathic Medicine, Wholeness Center , Fort Collins, CO.

Objectives: Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis. Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). This effect is believed to be due to the action of CBD on the endocannabinoid system. Read More

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December 2018

High fidelity moving Z-Score based controlled breakdown fabrication of solid-state nanopore.

Nanotechnology 2018 Nov 28. Epub 2018 Nov 28.

Electrical Engieering, Pennsylvania State University, 111F Electrical Engineering West, University Park, Pennsylvania, 16802-1503, UNITED STATES.

We investigate the current transport characteristics in the electrolyte-dielectric-electrolyte structure commonly used in the in-situ controlled breakdown (CBD) fabrication of solid-state nanopores. It is found that the stochastic breakdown process could lead to fidelity issues of false positives (an incorrect indication of a true nanopore formation) and false negatives (inability to detect initial nanopore formation). Robust and deterministic detection of initial physical breakdown to alleviate false positives and false negatives is critical for precise nanopore size control. Read More

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November 2018

Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors.

Neuropsychopharmacology 2018 Nov 27. Epub 2018 Nov 27.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5C1, Canada.

The use of cannabis for therapeutic and recreational purposes is growing exponentially. Nevertheless, substantial questions remain concerning the potential cognitive and affective side-effects associated with cannabis exposure. In particular, the effects of specific marijuana-derived phytocannabinoids on neural regions such as the prefrontal cortex (PFC) are of concern, given the role of the PFC in both executive cognitive function and affective processing. Read More

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November 2018

Evaluation of methods for generative modeling of cell and nuclear shape.

Bioinformatics 2018 Dec 7. Epub 2018 Dec 7.

Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, USA.

Motivation: Cell shape provides both a geometry for, and a reflection of, cell function. Numerous methods for describing and modeling cell shape have been described, but previous evaluation of these methods in terms of the accuracy of generative models has been limited.

Results: Here we compare traditional methods and deep autoencoders to build generative models for cell shapes in terms of the accuracy with which shapes can be reconstructed from models. Read More

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December 2018

A cabbage leaf like nanostructure of a NiS@ZnS composite on Ni foam with excellent electrochemical performance for supercapacitors.

Dalton Trans 2018 Dec 10. Epub 2018 Dec 10.

School of Electrical Engineering, Pusan National University, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea.

In the present study, a NiS@ZnS composite nanostructure was synthesized on a nickel foam substrate by a facile chemical bath deposition (CBD) method. The prepared composites were analyzed by X-ray photoelectron spectroscopy, high resolution transmission electron microscopy, and field emission scanning electron microscopy. The electrochemical performance of the supercapacitor (SC) electrodes was examined by cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy. Read More

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December 2018
3 Reads

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans.

Front Pharmacol 2018 26;9:1365. Epub 2018 Nov 26.

Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.

Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to collate published data in this area. Read More

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November 2018

Simultaneous quantification of thirteen cannabinoids and metabolites in human plasma by liquid chromatography tandem mass spectrometry in adult epilepsy patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Experimental and Clinical Pharmacology and.

Background: A sensitive, robust method was developed and validated to quantitate thirteen major natural cannabinoid parent and metabolite compounds in human plasma at or below 0.5 ng/mL.

Methods: A liquid chromatography-tandem mass spectrometry method was developed and validated to measure thirteen cannabinoid compounds: cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), Δ-tetrahydocannabinol (THC), Δ-tetrahydrocannabinolic acid A (THCA), Δ-tetrahydrocannabivarin (THCV), 11-hydroxy-Δ-tetrahydrocannbinol (11-OH-THC), 11-nor-9-carboxy-Δ-tetrahydrocannbinol (THC-COOH), and 11-nor-9-carboxy-Δ-tetrahydrocannabinol-glucuronide (THC-COOH-glu). Read More

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December 2018
2 Reads

Index Admission Emergency Laparoscopic Cholecystectomy and Common Bile Duct Exploration: Results From a Specialist Center in the United Kingdom.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Royal Derby Hospital, Uttoxeter Road, Derby, UK.

Background: The incidence of common bile duct (CBD) stones is between 10% to 18% in people undergoing cholecystectomy for gallstones. Laparoscopic exploration of the CBD is now becoming routine practice in the elective setting, however its safety and efficacy in emergencies is poorly understood.

Methods: We analyzed our results for index emergency admission laparoscopic cholecystectomy within a specialist center in the United Kingdom. Read More

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December 2018
1 Read

Crystal Structure of LysB4, an Endolysin from Bacillus cereus-Targeting Bacteriophage B4.

Mol Cells 2018 Dec 5. Epub 2018 Dec 5.

Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Center for Food Safety and Toxicology, Seoul National University, Seoul 08826, Korea.

Endolysins are bacteriophage-derived enzymes that hydrolyze the peptidoglycan of host bacteria. Endolysins are considered to be promising tools for the control of pathogenic bacteria. LysB4 is an endolysin produced by Bacillus cereus-infecting bacteriophage B4, and consists of an N-terminal enzymatic active domain (EAD) and a C-terminal cell wall binding domain (CBD). Read More

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December 2018

Cholangioscopy-guided electrohydraulic lithotripsy of a large bile duct stone through a percutaneous T-tube tract.

VideoGIE 2018 Dec 25;3(12):390-391. Epub 2018 Oct 25.

Department of Gastroenterology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.

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December 2018
1 Read

Endobiliary polypectomy of biliary tumor using a prototype dedicated cholangioscope with double-bending technology.

VideoGIE 2018 Dec 4;3(12):386-389. Epub 2018 Oct 4.

Department of Gastroenterology, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.

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December 2018
1 Read

Endoscopic restoration of completely transected and prolapsed common bile duct.

VideoGIE 2018 Dec 4;3(12):384-385. Epub 2018 Oct 4.

Social Security System of Costa Rica, Hospital of Liberia, Guanacaste, Costa Rica.

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December 2018
2 Reads

A case of hemobilia secondary to cancer of the gallbladder confirmed by cholangioscopy and treated with a fully covered self-expanding metal stent.

VideoGIE 2018 Dec 4;3(12):381-383. Epub 2018 Oct 4.

Department of Gastroenterology and Hepatology, St George Hospital, Kogarah, Australia.

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December 2018
2 Reads

Success of intraoperative imaging and management of suspected choledocholithiasis without pre-operative bile duct imaging - A case series.

Ann Med Surg (Lond) 2018 Dec 5;36:173-177. Epub 2018 Nov 5.

Consultant Upper GI Surgeon, South Devon NHS Foundation Trust, United Kingdom.

Background: Laparoscopic common bile duct exploration (LCBDE) is gaining popularity over endoscopic retrograde cholangiopancreatography (ERCP) for the management of common bile duct stones. However, its application has been almost exclusively following preoperative stone confirmation via magnetic retrograde cholangiopancreatography (MRCP), endoscopic ultrasound (EUS) or ERCP. We present our series of LCBDE following detection of common bile duct stones with intraoperative imaging (IOI) alone, in consecutive elective and emergency patients with suspected choledocholithiasis. Read More

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December 2018
1 Read

Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis.

Nat Commun 2018 11 30;9(1):5123. Epub 2018 Nov 30.

Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Bat 4R3, 118 route de Narbonne, F-31062, Toulouse, France.

To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. Read More

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November 2018
1 Read

Access and benefit sharing--The perspective of basic research.

Authors:
Erwin Beck

Phytomedicine 2018 Oct 26. Epub 2018 Oct 26.

University of Bayreuth, Department of Plant Physiology, Universitätsstr. 30, Bayreuth D 95440, Germany. Electronic address:

Background: With the adoption of the Convention on Biological Diversity (CBD) the 196 member countries have agreed that organisms and their derivatives are the property of the country of their origin (CBD Art.3, Art 15). While the spirit of the CBD is generally acknowledged, the ownership causes considerable problems, last not least for research which by the CBD is considered as "use of genetic (=biological) resources" (GR). Read More

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October 2018

Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Cannabis Cannabinoid Res 2018 30;3(1):228-241. Epub 2018 Nov 30.

Program in Neuroscience, Indiana University Bloomington, Bloomington, Indiana.

Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are bioactive cannabinoids. We recently showed that acute THC administration drives region-dependent changes in the mouse brain lipidome. This study tested the hypothesis that cell lines representing cell types present in the central nervous system (CNS), neurons (N18 cells), astrocytes (C6 glioma cells), and microglia (BV2 cells) would respond differently to THC, CBD, or their combination. Read More

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November 2018
1 Read

Comment on "Is it Useful to Classify PSP and CBD as Different Disorders?"

Authors:
Anthony E Lang

Mov Disord Clin Pract 2018 Sep-Oct;5(5):564-565. Epub 2018 Oct 3.

Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital Toronto Canada.

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October 2018

Laparoscopic common bile duct exploration plus cholecystectomy versus endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for cholecystocholedocholithiasis: a meta-analysis.

Surg Endosc 2018 Dec 3. Epub 2018 Dec 3.

Department of Hepatobiliary Surgery, Dongyang People's Hospital, Dongyang, 322100, Zhejiang, China.

Background: The purpose of the study was to compare the safety and effectiveness of laparoscopic common bile duct exploration plus laparoscopic cholecystectomy (LCBDE+LC) with preoperative endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy (pre-ERCP+LC) for cholecystocholedocholithiasis.

Methods: An electronic search was performed using the following databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov until 1 July 2018. Read More

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December 2018
2 Reads

Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal.

Mult Scler Relat Disord 2018 Nov 20;27:383-390. Epub 2018 Nov 20.

Department of Neurology, University of Colorado School of Medicine, 12700 East 19th Ave, B182, Aurora, CO 80045, United States. Electronic address:

Background: Studies suggest cannabis may improve symptoms like pain and muscle spasticity in patients with multiple sclerosis (PwMS). Despite cannabis' new-found legality and availability, few studies have explored the profile of PwMS cannabis users and characteristics of their use, particularly in a state where cannabis is legal both for recreational and medicinal use. The purpose of the current study was to evaluate cannabis use among PwMS at a large academic multiple sclerosis (MS) clinic, specifically: (1) prevalence, (2) products used (e. Read More

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November 2018
4 Reads

Use of fluorescent CTP1L endolysin cell wall-binding domain to study the evolution of Clostridium tyrobutyricum during cheese ripening.

Food Microbiol 2019 Apr 29;78:11-17. Epub 2018 Sep 29.

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Departamento de Tecnología de Alimentos, Carretera de La Coruña Km 7, 28040, Madrid, Spain.

Clostridium tyrobutyricum is a bacteria of concern in the cheese industry, capable of surviving the manufacturing process and causing butyric acid fermentation and late blowing defect of cheese. In this work, we implement a method based on the cell wall-binding domain (CBD) of endolysin CTP1L, which detects C. tyrobutyricum, to monitor its evolution in cheeses challenged with clostridial spores and in the presence or absence of reuterin, an anti-clostridial agent. Read More

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April 2019
2 Reads

Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl] Decrease in Ciliated Human Nasal Epithelial Cells.

Int J Mol Sci 2018 Nov 26;19(12). Epub 2018 Nov 26.

Research Center for Drug Discovery and Pharmaceutical Development Science, Research Organization of Science and Technology, BKC, Ritsumeikan University, Kusatsu 525-8577, Japan.

The effects of the isoflavone daidzein on the ciliary beat distance (CBD, which is a parameter assessing the amplitude of ciliary beating) and the ciliary beat frequency (CBF) were examined in ciliated human nasal epithelial cells (cHNECs) in primary culture. Daidzein decreased [Cl] and enhanced CBD in cHNECs. The CBD increase that was stimulated by daidzein was mimicked by Cl-free NO₃ solution and bumetanide (an inhibitor of Na⁺/K⁺/2Cl cotransport), both of which decreased [Cl] Moreover, the CBD increase was inhibited by 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB, a Cl channel blocker), which increased [Cl]. Read More

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November 2018

Emerging drugs for the treatment of Dravet syndrome.

Expert Opin Emerg Drugs 2018 Nov 27. Epub 2018 Nov 27.

d Neurology Unit, S. Anna Hospital , Como , Italy.

Introduction: Dravet syndrome (DS) is an early-onset genetic developmental epileptic encephalopathy characterized by multiple seizure types which are refractory to antiseizure medication. There is an unmet need for effective and tolerable drugs to control different seizure types in DS types, with the aim of improving quality of life and preventing neurological impairment. Areas covered: Narrative review of efficacy and tolerability of fenfluramine, cannabidiol (CBD), verapamil and modulators of serotonin signaling pathways (lorcaserin or trazodone) in the treatment of DS. Read More

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November 2018
3 Reads

Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.

Eur J Pharmacol 2018 Nov 24;843:251-259. Epub 2018 Nov 24.

Laboratory of Experimental Pathophysiology, Extreme University South of Santa Catarina, Criciúma, Brazil; Department of Pneumology, Asthma Research Centre, Federal University of Santa Catarina, Florianópolis, Brazil. Electronic address:

Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Asthma remains a major public health problem and, at present, there are no effective interventions capable of reversing airway remodelling. Cannabidiol (CBD) is known to exert immunomodulatory effects through the activation of cannabinoid-1 and - 2 (CB and CB) receptors located in the central nervous system and immune cells, respectively. Read More

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November 2018
16 Reads

Novel inverse agonists for the orphan G protein-coupled receptor 6.

Heliyon 2018 Nov 16;4(11):e00933. Epub 2018 Nov 16.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, 40292, United States.

The orphan G protein-coupled receptor 6 (GPR6) displays unique promise as a therapeutic target for the treatment of neuropsychiatric disorders due to its high expression in the striatopallidal neurons of the basal ganglia. GPR6, along with closely related orphan receptors GPR3 and GPR12, are phylogenetically related to CB1 and CB2 cannabinoid receptors. In the current study, we performed concentration-response studies on the effects of three different classes of cannabinoids: endogenous, phyto-, and synthetic, on both GPR6-mediated cAMP accumulation and β-arrestin2 recruitment. Read More

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November 2018

Cholecystectomy following percutaneous cholecystostomy tube placement leads to higher rate of CBD injuries.

Surg Endosc 2018 Nov 26. Epub 2018 Nov 26.

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, 100 Nichols Road, HSC T19, Stony Brook, NY, 11794, USA.

Introduction: Percutaneous cholecystostomy tube (PCT) placement is often the management of severe acute cholecystitis in the unstable patient. PCT can be later reversed and cholecystectomy performed. The purpose of this study is to investigate the incidence of subsequent cholecystectomy and clinical factors associated with subsequent procedure. Read More

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November 2018
6 Reads

An ethical appraisal of the choice of vaccines against Poliomyelitis.

Indian J Med Ethics 2018 Sep 21;-(-):1-4. Epub 2018 Sep 21.

Consultant in Paediatrics and Paediatric Infectious Diseases, Apollo Hospitals, CBD Belapur, Navi Mumbai 400614.,

Medical ethics is invoked for immunisation of children as it involves an interaction between a healthcare professional and the child. Immunisation under the national immunisation programme is a public health intervention and the common belief is that ethics is not relevant. Two vaccines with contrasting safety and efficacy profiles were available against polio before the national immunisation programme was launched: the inactivated poliovirus vaccine (IPV) and the live attenuated oral poliovirus vaccine (OPV). Read More

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September 2018
3 Reads

Perceptions on Competence by Design in urology.

Can Urol Assoc J 2018 Nov 20. Epub 2018 Nov 20.

Department of Medicine, Faculty of Education, Western University, London, ON, Canada.

Introduction: The Royal College of Physicians and Surgeons of Canada has begun implementing Competence by Design (CBD). However, it is unclear how much urology trainees and faculty know about CBD, their attitudes towards this change, and their willingness to embrace and participate in this new model of training.

Methods: This cross-sectional study was conducted through an online survey, which was administered to all trainees and faculty at Canadian urology programs prior to the implementation of CBD. Read More

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November 2018
3 Reads

Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for glioma therapy: In vitro screening of critical parameters.

Eur J Pharm Biopharm 2019 Jan 22;134:126-137. Epub 2018 Nov 22.

Department of Pharmaceutics and Food Technology, Complutense University, Madrid, Spain; University Institute of Industrial Pharmacy, Complutense University, Madrid, Spain. Electronic address:

The therapeutic potential of cannabinoids has been truly constrained heretofore due to their strong psychoactive effects and their high lipophilicity. In this context, precisely due to the lack of psychoactive properties, cannabidiol (CBD), the second major component of Cannabis sativa, arises as the phytocannabinoid with the most auspicious therapeutic potential. Hence, the incorporation of CBD in lipid nanocapsules (LNCs) will contribute to overcome the dosing problems associated with cannabinoids. Read More

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January 2019
3 Reads

Impact of recreational and medicinal marijuana on surgical patients: A review.

Am J Surg 2018 Nov 14. Epub 2018 Nov 14.

Penn State Health St. Joseph's Medical Center, 2494 Bernville Road, Reading, PA, 19605, USA. Electronic address:

Background: As medicinal and recreational marijuana use broadens across the United States, knowledge of its effects on the body will become increasingly important to all health care providers, including surgeons.

Data Sources: We performed a literature review of Pubmed for articles discussing the basic science related to cannabinoids, as well as articles regarding cannabinoid medications, and cannabis use in surgical patients.

Conclusions: The primary components in the cannabis plant, tetrahydrocannabinol (THC) and cannabidiol (CBD), have been made available in numerous forms and formulations to treat multiple medical conditions, and recreational access to marijuana is increasing. Read More

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November 2018
1 Read

High-Efficiency Cu(In,Ga)Se₂ Thin Film Solar Cells Using ZnS and CdS Buffer Layers.

J Nanosci Nanotechnol 2019 Mar;19(3):1814-1819

College of Electrical and Computer Engineering, Chungbuk National University, Cheongju, 28644, Korea.

Most of the existing copper indium gallium diselenide (CIGS) thin film solar cells are based on a cadmium sulfide (CdS) buffer layer fabricated using a chemical bath deposition (CBD) process. However, due to environmental pollution caused by material toxicity and the unique wet process's incompatibility with the vacuum process, many studies are now being actively carried out on nontoxic buffer layers. In this study, to replace CdS buffer layers, zinc sulfide (ZnS) buffer layers with a big band gap and a low optical loss at a short wavelength were fabricated using a magnetron sputtering system. Read More

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March 2019
1 Read

Preoperative Predictors of Choledocholithiasis in Patients Presenting with Acute Calculous Cholecystitis.

Gastrointest Endosc 2018 Nov 19. Epub 2018 Nov 19.

University of Michigan Health Care System; VA Healthcare System, Ann Arbor Michigan.

Background And Aims: Markedly elevated liver chemistries in patients presenting with acute calculous cholecystitis (AC) often prompt an evaluation for concomitant choledocholithiasis (CDL). However, current guidelines directing the workup for CDL fail to address this unique population. The aims of this study are to define the range of presenting lab values and imaging findings in AC, develop a model to predict the presence of concurrent CDL, and develop a management algorithm that can be easily applied on presentation. Read More

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November 2018
3 Reads

Developing and validating Parkinson's disease subtypes and their motor and cognitive progression.

J Neurol Neurosurg Psychiatry 2018 Dec 25;89(12):1279-1287. Epub 2018 Jul 25.

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK.

Objectives: To use a data-driven approach to determine the existence and natural history of subtypes of Parkinson's disease (PD) using two large independent cohorts of patients newly diagnosed with this condition.

Methods: 1601 and 944 patients with idiopathic PD, from Tracking Parkinson's and Discovery cohorts, respectively, were evaluated in motor, cognitive and non-motor domains at the baseline assessment. Patients were recently diagnosed at entry (within 3. Read More

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December 2018
2 Reads

Multimodality imaging: Bird's eye view from The European Society of Cardiology Congress 2018 Munich, August 25-29, 2018.

J Nucl Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiology, Heart Lung Centrum, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.

At the European Society of Cardiology (ESC) congress of this year 2018, held in Munich from August 25th to 29th, 4594 abstracts were presented. Of those, 423 (10.8%) belonged to an imaging category. Read More

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November 2018
2 Reads

PM and surface dust source characterization in Baguio City Central Business District (CBD), Philippines.

Environ Geochem Health 2018 Nov 20. Epub 2018 Nov 20.

Institute of Environmental Science and Meteorology, University of the Philippines Diliman, 1101, Quezon City, Philippines.

This study measured both PM and surface dust concentrations at roadside in the Central Business District of Baguio City. A total of 66 PM filters and 25 surface dust samples were analyzed for 14 metals (Na, Mg, Al, Ca, Cr, Mn, Co, Ni, Cu, Zn, As, Sr, Cd and Pb) using inductively coupled plasma mass spectrometer ICP-MS to characterize sources of airborne particulate matter (APM). Calculation of enrichment factors indicated elements Zn, Cd, Pb and As to be enriched in both PM and surface dust samples. Read More

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November 2018
2 Reads

The discovered chimeric protein plays the cohesive role to maintain scallop byssal root structural integrity.

Sci Rep 2018 Nov 20;8(1):17082. Epub 2018 Nov 20.

MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.

Adhesion is essential for many marine sessile organisms. Unraveling the compositions and assembly of marine bioadheisves is the fundamental to understand their physiological roles. Despite the remarkable diversity of animal bioadhesion, our understanding of this biological process remains limited to only a few animal lineages, leaving the majority of lineages remain enigmatic. Read More

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November 2018

Epilepsy and Cannabis: A Literature Review.

Cureus 2018 Sep 10;10(9):e3278. Epub 2018 Sep 10.

Internal Medicine, Basic Health Unit Larhi, Gambat, Gambat, PAK.

Epilepsy is considered to be one of the most common non-communicable neurological diseases especially in low to middle-income countries. Approximately one-third of patients with epilepsy have seizures that are resistant to antiepileptic medications. Clinical trials for the treatment of medically refractory epilepsy have mostly focused on new drug treatments, and result in a significant portion of subjects whose seizures remain refractory to medication. Read More

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September 2018
2 Reads

The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids.

Forensic Sci Int 2018 Nov 1. Epub 2018 Nov 1.

Virginia Commonwealth University, Department of Forensic Science, 1015 Floyd Avenue, Room 2015, Richmond, VA 23284, USA.

Electronic cigarettes (e-cigarettes) were developed as an alternative method for nicotine delivery and had a significant surge in popularity. E-liquids are formulations used in e-cigarettes, and consist of a ratio of propylene glycol (PG) and vegetable glycerin (VG), a pharmaceutical and/or herbal remedy and, usually, a flavoring agent. Presented is the evaluation of nine cannabidiol (CBD) e-liquids from a single manufacturer for cannabinoids and other psychoactive compounds by Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Gas Chromatography Mass Spectrometry (GC/MS). Read More

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November 2018

Biliary tract exploration through a common bile duct incision or left hepatic duct stump in laparoscopic left hemihepatectomy for left side hepatolithiasis: which is better?: A single-center retrospective case-control study.

Medicine (Baltimore) 2018 Nov;97(46):e13080

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu.

Laparoscopic left hemihepatectomy (LLH) followed by biliary tract exploration is used to treat left-sided hepatolithiasis (LSH). The purpose of this study was to compare the efficacy of 2 methods of biliary tract exploration in LLH:biliary tract exploration through a common bile duct (CBD) incision (with T-tube drainage) or through the left hepatic duct (LHD) stump (without T-tube drainage).LSH patients (113 patients) were recruited retrospectively in our hospital from December 2008 to January 2016. Read More

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November 2018
7 Reads

The reliability of a portfolio of workplace-based assessments in anesthesia training.

Can J Anaesth 2018 Nov 14. Epub 2018 Nov 14.

Centre for Medical and Health Sciences Education, School of Medicine, University of Auckland, Auckland, New Zealand.

Purpose: Competency-based anesthesia training programs require robust assessment of trainee performance and commonly combine different types of workplace-based assessment (WBA) covering multiple facets of practice. This study measured the reliability of WBAs in a large existing database and explored how they could be combined to optimize reliability for assessment decisions.

Methods: We used generalizability theory to measure the composite reliability of four different types of WBAs used by the Australian and New Zealand College of Anaesthetists: mini-Clinical Evaluation Exercise (mini-CEX), direct observation of procedural skills (DOPS), case-based discussion (CbD), and multi-source feedback (MSF). Read More

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November 2018
5 Reads

Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats.

Neurotox Res 2018 Nov 14. Epub 2018 Nov 14.

Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, CEP 87020-900, Brazil.

Diabetes and aging are risk factors for cognitive impairments after chronic cerebral hypoperfusion (CCH). Cannabidiol (CBD) is a phytocannabinoid present in the Cannabis sativa plant. It has beneficial effects on both cerebral ischemic diseases and diabetes. Read More

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November 2018
4 Reads

Ultrasensitive and Fast Diagnostics of Viable Cells by CBD Magnetic Separation Combined with A511:: Detection.

Viruses 2018 Nov 13;10(11). Epub 2018 Nov 13.

Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland.

The genus includes foodborne pathogens that cause life-threatening infections in those at risk, and sensitive and specific methods for detection of these bacteria are needed. Based on their unrivaled host specificity and ability to discriminate viable cells, bacteriophages represent an ideal toolbox for the development of such methods. Here, the authors describe an ultrasensitive diagnostic protocol for by combining two phage-based strategies: (1) specific capture and concentration of target cells by magnetic separation, harnessing cell wall-binding domains from phage endolysins (CBD-MS); and (2) highly sensitive detection using an adaptation of the A511:: bioluminescent reporter phage assay in a microwell plate format. Read More

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November 2018
1 Read

Use of a Lithotripter to Salvage a Bile duct stone and Kinking Retrieval Basket In the Distal Common Bile Duct.

Dig Endosc 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea.

A 65-year-old man was transferred from a secondary hospital after a bile duct stone and a retrieval basket became impacted in the common bile duct (CBD) during an endoscopic retrograde cholangiopancreatography (ERCP). Prior to transfer, lithotripsy after exchanging the basket sheath for a metal sheath was tried but failed because of the fracture of a wire near the patient's mouth. After transfer to our facility, we attempted an ERCP prior to considering surgery. Read More

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November 2018
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Systematics at the Levels of Family, Genus, and Species.

Cannabis Cannabinoid Res 2018 1;3(1):203-212. Epub 2018 Oct 1.

Department of Molecular Biology, GW Pharmaceuticals, Cambridge, United Kingdom.

New concepts are reviewed in systematics, including phylogenetics and nomenclature. The family now includes , , and eight genera formerly in the . Grouping , , and actually goes back 250 years. Read More

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October 2018
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Detection of Common Bile Duct Stones in Mild Acute Biliary Pancreatitis Using Magnetic Resonance Cholangiopancreatography.

Surg Res Pract 2018 22;2018:5216089. Epub 2018 Oct 22.

Department of General Surgery, Beilinson Hospital, Rabin Medical Center, Petach-Tikva, Israel.

Background: All patients with mild acute biliary pancreatitis should undergo early cholecystectomy. Whether routine common bile duct (CBD) imaging should be employed before the surgical procedure in these patients is a matter of current controversy. The aim of this study was to investigate the rate of detection of CBD stones using magnetic resonance cholangiopancreatography (MRCP) at different time intervals from admission. Read More

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October 2018
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Fluid biomarkers for frontotemporal dementias.

Neuropathol Appl Neurobiol 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Frontotemporal dementias (FTDs) are clinically, genetically and pathologically heterogeneous neurodegenerative disorders that affect the frontal and anterior temporal lobes of the brain. They are relatively common causes of young-onset dementia and usually present with behavioural disturbance (behavioural variant FTD) or language impairment (primary progressive aphasia), but there is also overlap with motor neurone disease and the atypical parkinsonian disorders, corticobasal syndrome and progressive supranuclear palsy. At post mortem, neuronal inclusions containing tau, TDP-43 or infrequently FUS protein are seen in most cases. Read More

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November 2018
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