6,381 results match your criteria CBD Lipid Signaling [Journal]


Laparoscopic Transcystic Versus Transductal Common Bile Duct Exploration: A Systematic Review and Meta-analysis.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of General Surgery, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Objective: To evaluate comparative outcomes of laparoscopic transcystic (TC) and transductal (TD) common bile duct (CBD) exploration.

Methods: We systematically searched MEDLINE, EMBASE, CINAHL, CENTRAL, the World Health Organization International Clinical Trials Registry, ClinicalTrials.gov, ISRCTN Register, and bibliographic reference lists. Read More

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http://dx.doi.org/10.1007/s00268-019-05005-yDOI Listing

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.

Clin Ter 2019 Mar-Apr;170(2):e93-e99

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.

Objective: To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.

Methods: A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment. Read More

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http://dx.doi.org/10.7417/CT.2019.2116DOI Listing

The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis.

Authors:
Felix B Yap

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e520-e523. Epub 2019 Mar 28.

Department of Medicine, Faculty of Medicine & Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia.

Objectives: This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD).

Methods: This retrospective study involved 32 patients with SSD who were prescribed CBD gel at the Subang Jaya Medical Centre, Selangor, Malaysia, between January 2016 and December 2017. The Physician Global Assessment Scale was used to assess disease severity. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443272PMC
November 2018
1 Read

Future Aspects for Cannabinoids in Breast Cancer Therapy.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Cannabinoids (CBs) from provide relief for tumor-associated symptoms (including nausea, anorexia, and neuropathic pain) in the palliative treatment of cancer patients. Additionally, they may decelerate tumor progression in breast cancer patients. Indeed, the psychoactive delta-9-tetrahydrocannabinol (THC), non-psychoactive cannabidiol (CBD) and other CBs inhibited disease progression in breast cancer models. Read More

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https://www.mdpi.com/1422-0067/20/7/1673
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http://dx.doi.org/10.3390/ijms20071673DOI Listing
April 2019
1 Read

Iatrogenic bile duct Injury with a retained T-tube in common bile duct for 10 years: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15127

Department of Pancreatic Surgery.

Rationale: Bile duct injury (BDI), a major complication of cholecystectomy, usually needs hepaticojejunostomy or primary repair over T-tube in severe cases. There were few cases about retained fragments of T-tube. Whereas, intact T-tube retained in common bile duct (CBD) for years after BDI was very rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000015127DOI Listing

Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System.

Alzheimers Dement (Amst) 2019 Dec 2;11:301-309. Epub 2019 Apr 2.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Introduction: Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials in atypical parkinsonian disorders. Read More

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http://dx.doi.org/10.1016/j.dadm.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446052PMC
December 2019

[Risk factors analysis of coronal imbalance after posterior long-level fixation and transforaminal lumbar interbody fusion for degenerative lumbar scoliosis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):430-435

Department of Orthopedics, Second Affiliated Hospital of Army Medical University, Chongqing, 400037,

Objective: To explore the risk factors of coronal imbalance after posterior long-level fixation and fusion for degenerative lumbar scoliosis.

Methods: Retrospectivly analyzed the clinical records of 41 patients with degenerative lumbar scoliosis who had received posterior long-level fixation and fusion with selective transforaminal lumbar interbody fusion (TLIF) accompanied by Ponte osteotomy between August 2011 and July 2016. Patients were divided into imbalance group (group A, 11 cases) and balance group (group B, 30 cases) according to state of coronal imbalance measured at last follow-up. Read More

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http://dx.doi.org/10.7507/1002-1892.201807149DOI Listing

Should CBD Be Part of My Patients' Treatment?

Authors:
Dick Benson

Altern Ther Health Med 2019 Jan;25(1):8-11

No Abstract Available. Read More

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January 2019

Beyond CBD: Exploring the Endocannabinoid System in Health and Disease.

Authors:
Carl Germano

Altern Ther Health Med 2018 Jun;24(S1):22-24

No Abstract Available. Read More

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The Bone Regeneration Capacity of 3D-Printed Templates in Calvarial Defect Models: A Systematic Review and Meta-Analysis.

Acta Biomater 2019 Apr 10. Epub 2019 Apr 10.

Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Norway. Årstadveien 19, 5009 Bergen, Norway. Electronic address:

3D-printed templates are being used for bone tissue regeneration (BTR) as temporary guides. In the current review, we analyze the factors considered in producing potentially bioresorbable/degradable 3D-printed templates and their influence on BTR in calvarial bone defect (CBD) animal models. In addition, a meta-analysis was done to compare the achieved BTR for each type of template material (polymer, ceramic or composites). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.017DOI Listing

Identification of an endo-chitinase from Corallococcus sp. EGB and evaluation of its antifungal properties.

Int J Biol Macromol 2019 Apr 10. Epub 2019 Apr 10.

Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Science, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

As the main component of the fungal cell wall, chitin has been regarded as an optimal molecular target for the biocontrol of plant-pathogenic fungi. In this study, the chitin hydrolase CcCti1, which belongs to the glycoside hydrolase family 18 (GH 18) and exhibits potential antifungal activity, was identified from Corallococcus sp. EGB. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.056DOI Listing

Sulfatase 2 promotes generation of a spinal cord astrocyte subtype that stands out through the expression of Olig2.

Glia 2019 Apr 13. Epub 2019 Apr 13.

Centre de Biologie du Développement (CBD) CNRS/UPS, Centre de Biologie Intégrative (CBI), Université de Toulouse, Toulouse, France.

Generation of glial cell diversity in the developing spinal cord is known to depend on spatio-temporal patterning programs. In particular, expression of the transcription factor Olig2 in neural progenitors of the pMN domain is recognized as critical to their fate choice decision to form oligodendrocyte precursor cells (OPCs) instead of astrocyte precursors (APs). However, generating some confusion, lineage-tracing studies of Olig2 progenitors in the spinal cord provided evidence that these progenitors also generate some astrocytes. Read More

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http://dx.doi.org/10.1002/glia.23621DOI Listing

Can Gossip Buffer the Effect of Job Insecurity on Workplace Friendships?

Int J Environ Res Public Health 2019 Apr 10;16(7). Epub 2019 Apr 10.

Business School, Queensland University of Technology, 2 George Street, Brisbane, QLD 4000, Australia.

Although previous research has documented a host of negative consequences of job insecurity, workplace interpersonal relationships have rarely been considered. This omission might be caused by the application of broad stress theories to the job insecurity literature without taking a nuanced perspective to understand the nature of job insecurity. To address this issue, we conceptualized job insecurity as a threat to employee social acceptance by their employer. Read More

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http://dx.doi.org/10.3390/ijerph16071285DOI Listing

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs.

Front Neurol 2019 27;10:277. Epub 2019 Mar 27.

Department of Medicinal Chemistry, University of Utah, Salt Lake, UT, United States.

Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy. The music playlist was created based on the modular progression of Mozart compositions for which reduction of seizures and epileptiform discharges were previously reported in people with epilepsy. Read More

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http://dx.doi.org/10.3389/fneur.2019.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446215PMC
March 2019
1 Read

Novel chemical route for CeO/MWCNTs composite towards highly bendable solid-state supercapacitor device.

Sci Rep 2019 Apr 10;9(1):5892. Epub 2019 Apr 10.

Department of Optical Science, Tokushima University, 2-1 Minamijosanjima Cho, Tokushima, 7708506, Japan.

Electrode materials having high capacitance with outstanding stability are the critical issues for the development of flexible supercapacitors (SCs), which have recently received increasing attention. To meet these demands, coating of CeO nanoparticles have been performed onto MWCNTs by using facile chemical bath deposition (CBD) method. The formed CeO/MWCNTs nanocomposite exhibits excellent electrochemical specific capacitance of 1215. Read More

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http://dx.doi.org/10.1038/s41598-019-42301-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458112PMC

Targeted antibody and cytokine cancer immunotherapies through collagen affinity.

Sci Transl Med 2019 Apr;11(487)

Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Cancer immunotherapy with immune checkpoint inhibitors (CPIs) and interleukin-2 (IL-2) has demonstrated clinical efficacy but is frequently accompanied with severe adverse events caused by excessive and systemic immune system activation. Here, we addressed this need by targeting both the CPI antibodies anti-cytotoxic T lymphocyte antigen 4 antibody (αCTLA4) + anti-programmed death ligand 1 antibody (αPD-L1) and the cytokine IL-2 to tumors via conjugation (for the antibodies) or recombinant fusion (for the cytokine) to a collagen-binding domain (CBD) derived from the blood protein von Willebrand factor (VWF) A3 domain, harnessing the exposure of tumor stroma collagen to blood components due to the leakiness of the tumor vasculature. We show that intravenously administered CBD protein accumulated mainly in tumors. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau3259DOI Listing
April 2019
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THC and CBD concentrations in blood, oral fluid and urine following a single and repeated administration of "light cannabis".

Clin Chem Lab Med 2019 Apr 8. Epub 2019 Apr 8.

Lambert Center for the Study of Medicinal Cannabis and Hemp, Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.

Background "Light cannabis" is a product legally sold in Europe with Δ9-tetrahydrocannabinol (THC) concentration lower than 0.2% and variable cannabidiol (CBD) content. We studied THC and CBD excretion profiles in blood, oral fluid (OF) and urine after smoking one or four light cannabis cigarettes. Read More

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http://dx.doi.org/10.1515/cclm-2019-0119DOI Listing
April 2019
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Don't Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy.

Authors:
M Scott Perry

Epilepsy Curr 2019 Mar-Apr;19(2):93-95

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897. Read More

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http://dx.doi.org/10.1177/1535759719835671DOI Listing
April 2019
6 Reads

Determination of Procalcitonin, C-Reactive Protein and White Blood Cell Levels to Diagnose Community-Acquired Pneumonia (CAP).

Indian J Pediatr 2019 Apr 4. Epub 2019 Apr 4.

Children's Hospital, Shaanxi Provincial People's Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.

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http://dx.doi.org/10.1007/s12098-019-02938-zDOI Listing
April 2019
1 Read

Patient involvement in resident assessment within the Competence by Design context: a mixed-methods study.

Can Med Educ J 2019 Mar 13;10(1):e84-e102. Epub 2019 Mar 13.

Department of Emergency Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada.

Background: Patients can contribute to resident assessment in Competence by Design (CBD). This study explored the extent, nature, as well as the facilitators and hindrances of patient involvement in resident assessment within and across Canadian specialty/sub-specialty/special programs that are transitioning or have transitioned to CBD.

Methods: We used a two-phase sequential explanatory mixed-methods design. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445318PMC

Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity.

Front Pharmacol 2019 20;10:226. Epub 2019 Mar 20.

National Research Council of Canada, Halifax, NS, Canada.

In this study, we aimed to investigate the effect of the two main active cannabinoids extracted from cannabis: Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on two distinct behavioral models of induced neuro-hyperactivity. We have taken advantage of two previously developed zebrafish models of neuro-hyperactivity: a chemically induced pentylenetetrazole model and a genetic model caused by loss-of-function mutations in the GABA receptor subunit alpha 1 (). Both CBD and THC have a significant effect on the behavioral changes induced by both models. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2019.00226
Publisher Site
http://dx.doi.org/10.3389/fphar.2019.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435997PMC
March 2019
6 Reads

Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature.

Cannabis Cannabinoid Res 2019 13;4(1):3-9. Epub 2019 Mar 13.

Department of Pediatrics, MIND Institute, University of California Davis Medical Center, Sacramento, California.

Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS. The objective of this study was to provide a brief narrative review of recent literature on endocannabinoids and FXS and to present a case series describing three patients with FXS who were treated with oral CBD-enriched (CBD+) solutions. Read More

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http://dx.doi.org/10.1089/can.2018.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446166PMC
March 2019
2 Reads

In vivo topology converts competition for cell-matrix adhesion into directional migration.

Nat Commun 2019 04 3;10(1):1518. Epub 2019 Apr 3.

Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062, Toulouse, Cedex 09, France.

When migrating in vivo, cells are exposed to numerous conflicting signals: chemokines, repellents, extracellular matrix, growth factors. The roles of several of these molecules have been studied individually in vitro or in vivo, but we have yet to understand how cells integrate them. To start addressing this question, we used the cephalic neural crest as a model system and looked at the roles of its best examples of positive and negative signals: stromal-cell derived factor 1 (Sdf1/Cxcl12) and class3-Semaphorins. Read More

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http://www.nature.com/articles/s41467-019-09548-5
Publisher Site
http://dx.doi.org/10.1038/s41467-019-09548-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447549PMC
April 2019
1 Read

Relating characteristics of global biodiversity targets to reported progress.

Conserv Biol 2019 Apr 2. Epub 2019 Apr 2.

RSPB Centre for Conservation Science, The Lodge, Potton Rd, Sandy, UK, SG19 2DL.

To inform governmental discussions on the nature of a revised Strategic Plan on Biodiversity of the Convention on Biological Diversity (CBD), we reviewed the relevant literature and assessed the framing of the 20 Aichi Biodiversity Targets in the current Strategic Plan. We asked international experts from non-governmental organizations, academia, government agencies, international organizations, research institutes and the CBD to score the Aichi Targets and their constituent elements against a set of 'SMART'-based criteria: Specific, Measurable, Ambitious, Realistic, Unambiguous, Scalable and Comprehensive (excluding 'Time-bound' as all targets are bound to 2015 or 2020). We then investigated the relationship between these expert scores and reported progress towards the target elements using the findings from two global progress assessments (Global Biodiversity Outlook and the Intergovernmental science-policy Platform on Biodiversity and Ecosystem Services). Read More

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http://dx.doi.org/10.1111/cobi.13322DOI Listing

Parameters Suggesting Spontaneous Passage of Stones from Common Bile Duct: A Retrospective Study.

Can J Gastroenterol Hepatol 2019 3;2019:5382708. Epub 2019 Mar 3.

Department of Surgery, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

Background: Common bile duct (CBD) stones are common. However, they are known to pass spontaneously, which obviates the need for ERCP.

Aim: The aim of this study is to identify specific predictors for spontaneous passage of CBD stones. Read More

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http://dx.doi.org/10.1155/2019/5382708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420964PMC
March 2019
1 Read

Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.

Drugs Today (Barc) 2019 Mar;55(3):177-196

Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy; Division of Neurology, "Franz Tappeiner" Hospital, Merano, Bolzano, Italy.

Epilepsy is one of the most common chronic disorders of the brain affecting around 70 million people worldwide. Treatment is mainly symptomatic, and most patients achieve long-term seizure control. Up to one-third of the affected subjects, however, are resistant to anticonvulsant therapy. Read More

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http://dx.doi.org/10.1358/dot.2019.55.3.2909248DOI Listing
March 2019
2 Reads

Long-term outcomes after biliary diversion operation for pancreaticobiliary maljunction in adult patients.

Ann Gastroenterol Surg 2019 Mar 19;3(2):217-223. Epub 2019 Feb 19.

Department of Pediatric Surgery Osaka City University Graduate School of Medicine Osaka Japan.

Aim: Pancreaticobiliary maljunction (PBM) with or without congenital biliary dilatation (CBD) is a risk factor for biliary tract cancer. We investigated long-term outcomes after biliary diversion operation with special reference to types of CBD.

Methods: Subjects comprised 40 adult patients who underwent biliary diversion operation for PBM without biliary tract cancer. Read More

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http://dx.doi.org/10.1002/ags3.12239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422791PMC
March 2019
1 Read

Standardization of common bile duct size using ultrasound in pediatric patients.

J Pediatr Surg 2019 Mar 1. Epub 2019 Mar 1.

Division of Pediatric General, Thoracic and Minimally Invasive Surgery, St. Christopher's Hospital for Children, Philadelphia, PA. Electronic address:

Background/purpose: The incidence of choledocholithiasis is increasing. The diagnosis of common bile duct (CBD) obstruction is based on abnormal CBD size. Establishing norms for CBD size in children would improve diagnostic accuracy. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.050DOI Listing

A Phase 1, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics and Safety of Cannabidiol (CBD) in Subjects With Mild to Severe Hepatic Impairment.

J Clin Pharmacol 2019 Mar 28. Epub 2019 Mar 28.

GW Research Ltd, Cambridge, United Kingdom.

The pharmacokinetics and safety of a single oral dose of 200-mg plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD) in oral solution (Epidiolex in the United States; 100 mg/mL) were assessed in subjects with mild to severe hepatic impairment (n =  8 each for mild and moderate, n = 6 for severe) relative to matched subjects with normal hepatic function (n = 8). Blood samples were collected until 48 hours after dosing and evaluated by liquid chromatography and tandem mass spectrometry. Pharmacokinetic parameters (primarily maximum measured plasma concentration, area under the plasma concentration-time curve from time zero to time t, area under the concentration-time curve from time zero to infinity, time to maximum plasma concentration, and terminal half-life) of CBD and its major metabolites were derived using non-compartmental analysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcph.1412
Publisher Site
http://dx.doi.org/10.1002/jcph.1412DOI Listing
March 2019
3 Reads

Joints for joints: cannabinoids in the treatment of rheumatoid arthritis.

Curr Opin Rheumatol 2019 May;31(3):271-278

Poliklinik, Funktionsbereich & Hiller Forschungszentrum für Rheumatologie, University Hospital Duesseldorf, Duesseldorf, Germany.

Purpose Of Review: An increasing number of patients with rheumatoid arthritis (RA) are using cannabis to treat their symptoms, although systematic studies regarding efficacy in RA are lacking. Within this review we will give an overview on the overall effects of cannabinoids in inflammation and why they might be useful in the treatment of RA.

Recent Findings: Peripherally, cannabinoids show anti-inflammatory effects by activating cannabinoid type 2 receptors (CB2) which decrease cytokine production and immune cell mobilization. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000590DOI Listing
May 2019
3 Reads

The Surprising Reach of FDA Regulation of Cannabis, Even After Descheduling.

Am Univ Law Rev 2019;68(3):823-925

University of Missouri School of Law.

As more states legalize cannabis, the push to "deschedule" it from the Controlled Substances Act is gaining momentum. At the same time, the Food and Drug Administration (FDA) recently approved the first conventional drug containing a cannabinoid derived from cannabis—cannabidiol (CBD) for two rare seizure disorders. This would all seem to bode well for proponents of full federal legalization of medical cannabis. Read More

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January 2019

Targeting microbial pathogens by expression of new recombinant dermaseptin peptides in tobacco.

Microbiologyopen 2019 Mar 25:e837. Epub 2019 Mar 25.

Agricultural Biotechnology Department, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.

Dermaseptin B1 (DrsB1), an antimicrobial cationic 31 amino acid peptide, is produced by Phyllomedusa bicolor. In an attempt to enhance the antimicrobial efficacy of DrsB1, the DrsB1 encoding 93 bp sequence was either fused to the N or C terminus of sequence encoding chitin-binding domain (CBD) of Avr4 gene from Cladosporium fulvum. Tobacco leaf disk explants were inoculated with Agrobacterium rhizogenes harboring pGSA/CBD-DrsB1 and pGSA/DrsB1-CBD expression vectors to produce hairy roots (HRs). Read More

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http://dx.doi.org/10.1002/mbo3.837DOI Listing

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment.

Life Sci 2019 May 22;224:120-127. Epub 2019 Mar 22.

Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy. Electronic address:

The pharmacological research on the Cannabis sativa-derived compounds has never terminated. Among the phytocannabinoids without psychotropic effects, the prevalent one in Cannabis is cannabidiol (CBD). Although CBD was initially considered a type 2 cannabinoid receptor (CB2R) antagonist, it did not show a good cannabinoidergic activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193021
Publisher Site
http://dx.doi.org/10.1016/j.lfs.2019.03.053DOI Listing
May 2019
4 Reads

Patterns of Medical Cannabis Use among Cancer Patients from a Medical Cannabis Dispensary in New York State.

J Palliat Med 2019 Mar 25. Epub 2019 Mar 25.

1 Department of Medicine, New York University School of Medicine, New York, New York.

Background: Research on the patterns of use of medical cannabis among cancer patients is lacking.

Objective: To describe patterns of medical cannabis use by patients with cancer, and how patterns differ from patients without cancer.

Design/measurements: We performed secondary data analysis using data from a medical cannabis licensee in New York State, analyzing demographic information, qualifying conditions, and symptoms, and the medical cannabis product used, including tetrahydrocannabinol (THC) to cannabidiol (CBD) ratios. Read More

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http://dx.doi.org/10.1089/jpm.2018.0529DOI Listing
March 2019
1 Read

HIV self-testing: breaking the barriers to uptake of testing among men and adolescents in sub-Saharan Africa, experiences from STAR demonstration projects in Malawi, Zambia and Zimbabwe.

J Int AIDS Soc 2019 Mar;22 Suppl 1:e25244

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Introduction: Social, structural and systems barriers inhibit uptake of HIV testing. HIV self-testing (HIVST) has shown promising uptake by otherwise underserved priority groups including men, young people and first-time testers. Here, we use characteristics of HIVST kit recipients to investigate delivery to these priority groups during HIVST scale-up in three African countries. Read More

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http://dx.doi.org/10.1002/jia2.25244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432104PMC
March 2019
1 Read

The role of time and storage conditions on the composition of hashish and marijuana samples: A four-year study.

Forensic Sci Int 2019 Mar 8;298:131-137. Epub 2019 Mar 8.

Laboratory of Environmental Hygiene and Forensic Toxicology, DMPO Department, AULSS 3 Serenissima, Venice, Italy.

The aim of this study was to investigate the role of time and different real-life storage conditions on the composition of different varieties of cannabis products (hashish and marijuana). Six high-potency cannabis products constituted by herbal and resin materials containing different initial concentrations of delta 9-Tetrahydrocannabinol (THC) were employed for this study. Four representative samples were collected from each study material and were maintained for a prolonged time (four years) under different controlled storage conditions: (A) light (24 h) and room temperature (22°C); (B) darkness (24 h) and room temperature; (C) darkness and refrigeration (4 °C); (D) darkness and freezing (-20 °C). Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.02.058DOI Listing

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil; Institute of Neurosciences and Behavior (INeC) and Laboratory of Neuropsychopharmacology of Faculty of Philosophy, Sciences and Letters of University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193015
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http://dx.doi.org/10.1016/j.brainres.2019.03.014DOI Listing
March 2019
6 Reads

A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains.

Front Immunol 2019 6;10:369. Epub 2019 Mar 6.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

The gut microbiome of animals consists of diverse microorganisms that include both prokaryotes and eukaryotes. Complex interactions occur among these inhabitants, as well as with the immune system of the host, and profoundly influence the overall health of both the host and its microbial symbionts. Despite the enormous importance for the host to regulate its gut microbiome, the extent to which animals generate immune-related molecules with the capacity to directly influence polymicrobial interactions remains unclear. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414549PMC

Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray: A Systematic Review of Observational Studies.

J Cent Nerv Syst Dis 2019 11;11:1179573519831997. Epub 2019 Mar 11.

Department of Neurology, Center of Clinical Neuroscience, University Hospital Dresden, Dresden, Germany.

Background/purpose: Spasticity is one of the most common symptoms in people with multiple sclerosis (MS). Conventional anti-spasticity agents have limitations in their efficacy and tolerability. Delta-9-tetrahydrocannabinol: cannabidiol (THC:CBD) spray, a cannabinoid-based medicine, is approved as an add-on therapy for MS spasticity not adequately controlled by other anti-spasticity medications. Read More

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http://dx.doi.org/10.1177/1179573519831997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413425PMC
March 2019
3 Reads

Allergenic ingredients in commercial topical cannabinoid preparations.

J Am Acad Dermatol 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1016/j.jaad.2019.03.015DOI Listing

Cannabidiol: The Need for More Information About Its Potential Benefits and Side Effects.

Authors:
Karen Hande

Clin J Oncol Nurs 2019 Apr;23(2):131-134

Vanderbilt University.

Consumer demand for cannabidiol (CBD) oil has increased, with growing sales from dispensaries because of the alleged medicinal benefits. Although studies examining the specific therapeutic effects of CBD are increasing, clinical data do not support the popular uses of CBD for Parkinson disease, schizophrenia, cancer palliation and treatment, chronic pain and spasticity, depression, anxiety disorder, insomnia, and inflammation. Read More

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http://dx.doi.org/10.1188/19.CJON.131-134DOI Listing
April 2019
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"Invisible" pancreatic masses identified by EUS by the "ductal cutoff sign".

Endosc Ultrasound 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology, Geisinger Health System, Danville, Pennsylvania, USA.

Making a tissue diagnosis of pancreatic adenocarcinoma is best accomplished by EUS and fine-needle aspiration (FNA) of the lesion. Typically, a dark, or "hypoechoic" mass will be seen, which presents an obvious target for FNA. For small lesions, computerized tomography (CT) may be negative, but the lesion is still almost always seen on EUS imaging. Read More

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http://dx.doi.org/10.4103/eus.eus_49_15DOI Listing

Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.

Eur Neuropsychopharmacol 2019 Mar 14. Epub 2019 Mar 14.

Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, The Netherlands. Electronic address:

The relation of heavy cannabis use with decreased neuropsychological function has frequently been described but the underlying biological mechanisms are still largely unknown. This study investigates the relation of cannabis use with genome wide gene expression and subsequently examines the relations with neuropsychological function. Genome-wide gene expression in whole blood was compared between heavy cannabis users (N = 90) and cannabis naïve participants (N = 100) that were matched for psychotic like experiences. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.03.004DOI Listing

Role Of Choledochoduodenostomy Revisited In The Era Of Minimal Invasive Procedures.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):86-89

Department of Surgery, Ayub Teaching Hospital Abbottabad, Pakistan.

Background: Present era of endoscopic and laparoscopic approaches have revolutionized surgical management of Common Bile Duct (CBD) stones. Open procedures like Choledochoduodenostomy (CDD) have become a rarity but are not completely obsolete. It may be considered a relatively safe alternative when dealing with recurrent, too large or impacted stones, a failed ERCP, and CBD stricture with stones. Read More

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March 2019
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CBD as the New Medicine in the Pain Provider's Armamentarium.

Pain Ther 2019 Mar 12. Epub 2019 Mar 12.

Valley Pain Consultants, Phoenix, AZ, USA.

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http://dx.doi.org/10.1007/s40122-019-0117-1DOI Listing

Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis.

Neural Dev 2019 Mar 13;14(1). Epub 2019 Mar 13.

Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse; CNRS, UPS, Toulouse, France.

In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of this process, from tissue-scale morphogens patterning to intrinsic determinants in neural progenitor cells. In a previous study (Bonnet et al. Read More

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http://dx.doi.org/10.1186/s13064-019-0131-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417072PMC
March 2019
1 Read

Epidemiology and disease characteristics of symptomatic choledocholithiasis in Sri Lanka.

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):41-45. Epub 2019 Feb 28.

Department of Surgery, Faculty of Medical Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka.

Backgrounds/aims: Published data on choledocholithiasis in Sri Lanka is scarce. This study was conducted to determine epidemiological, clinical and endoscopic characteristics of choledocholithiasis in Sri Lanka.

Methods: This was a retrospective study of consecutive patients for a period of three years until April 2016. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14701/ahbps.2019
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http://dx.doi.org/10.14701/ahbps.2019.23.1.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405359PMC
February 2019
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Intein-mediated expression and purification of common carp IFN-γ and its protective effect against spring viremia of carp virus.

Fish Shellfish Immunol 2019 May 9;88:403-406. Epub 2019 Mar 9.

College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi Province, 330022, China. Electronic address:

IFN-γ is a pleiotropic cytokine with significant roles in antiviral, antitumor and immune regulation. It could be used as an immuno-enhancer to improve fish protectiveness against pathogens. In this study, the prokaryotic expression plasmid pTwin1-N-IFN-γ was constructed to express Cyprinus carpio (common carp) IFN-γ fused with a chitin binding domain (CBD) and a self-cleavable intein-tag, Synechocystis sp DnaB. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.03.022DOI Listing
May 2019
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Bilirubin Correlation May Preclude MRCP in Acute Cholecystitis Patients With Normal Common Bile Duct Diameter.

AJR Am J Roentgenol 2019 Mar 12:1-6. Epub 2019 Mar 12.

1 Department of Radiology, Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY 10305.

Objective: In patients with acute cholecystitis (AC), accurate identification of a common bile duct (CBD) stone before cholecystectomy is of concern for surgeons, gastroenterologists, and radiologists. This study evaluates the utility of preoperative MRCP taking into consideration both sonographic findings and biochemical predictors for choledocholithiasis.

Materials And Methods: Fifty-seven patients (58% women; mean age, 54 years old) with signs of AC on right upper quadrant (RUQ) ultrasound (US) who underwent subsequent MRCP from 2007 to 2017 were identified using a text-based search and retrospectively analyzed, using ERCP as the reference standard. Read More

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http://dx.doi.org/10.2214/AJR.18.20613DOI Listing
March 2019
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Epidiolex as adjunct therapy for treatment of refractory epilepsy: a comprehensive review with a focus on adverse effects.

F1000Res 2019 28;8. Epub 2019 Feb 28.

Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Medically refractory epilepsy remains an area of intense clinical and scientific interest since a significant porportion of patients continue to suffer from debilitating seizures despite available therapies. In this setting, recent studies have focused on assessing the benefits of cannabidiol (CBD)-enriched cannabis, a plant based product without psychoactive properties which has been shown to decrease seizure frequency in animal models. More recently, several randomized controlled and open label trials have studied the effects of Epidiolex, a 99% pure oral CBD extract, on patients with refractory epilepsy. Read More

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https://f1000research.com/articles/8-234/v1
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http://dx.doi.org/10.12688/f1000research.16515.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396837PMC
February 2019
4 Reads