Mol Pharmacol 2015 Jul 22;88(1):64-74. Epub 2015 Apr 22.
Department of Molecular and Cellular Biochemistry (L.D.), Department of Psychological and Brain Sciences (L.D., B.L.C., K.M., A.G.H.), The Linda and Jack Gill Center for Biomolecular Science (L.D., B.L.C., K.M., A.G.H.), Indiana University, Bloomington, Indiana
Cannabinoids suppress neuropathic pain through activation of cannabinoid CB1 and/or CB2 receptors; however, unwanted CB1-mediated cannabimimetic effects limit clinical use. We asked whether CP55,940 [(-)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexanol], a potent cannabinoid that binds with similar affinity to CB1 and CB2 in vitro, produces functionally separable CB1- and CB2-mediated pharmacological effects in vivo. We evaluated antiallodynic effects, possible tolerance, and cannabimimetic effects (e. Read More