1,297,721 results match your criteria CA Cancer J Clin[Journal]


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

DNA methylation acts at the interface of genetic and environmental factors relevant for autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child. Here, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) of high-risk pregnancies. Read More

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http://dx.doi.org/10.1093/hmg/ddz084DOI Listing

Inherent thermal regeneration performance of different MnO crystallographic structures for mercury removal.

J Hazard Mater 2019 Apr 3;374:267-275. Epub 2019 Apr 3.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada; Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. Electronic address:

Manganese oxides with different crystallographic structures were investigated for gas-phase elemental mercury removal. The inherent thermal regeneration performance and mechanism of α- and γ-MnO were studied. The manganese dioxides were found to possess a mercury removal efficiency of higher than 96% even after 120 min mercury exposure except for β-MnO which removed much less mercury than MnO. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.006DOI Listing

Re-imagining miyo-wicehtowin: Human-nature relations, land-making, and wellness among Indigenous youth in a Canadian urban context.

Soc Sci Med 2019 Apr 13;230:122-130. Epub 2019 Apr 13.

Wiyasiwewin Mikiwahp Native Law Centre, College of Law, University of Saskatchewan, Canada.

Relationships to land and nature have long been recognized globally as a central Indigenous determinant of health. As more Indigenous peoples migrate to larger urban centers, it is crucial to better understand how these relationships are maintained or function within urban spaces. This article outlines the results of a year-long collaborative study that qualitatively explored Indigenous young peoples' connections between "land," nature, and wellness in an urban Canadian context. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.04.012DOI Listing

A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice.

J Pharm Biomed Anal 2019 Apr 8;171:180-192. Epub 2019 Apr 8.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address:

The pathology of cholestatic liver injury (CLI) was complicated, which has limited the development of anti-cholestatic drugs for a long period. Metabolomic researches focused on global and dynamic changes of the organism could shed some light on mechanism investigation. In order to characterize and validate metabolite alterations of alpha-naphthylisothiocyanate (ANIT) induced CLI in C57BL/6 mice, a systemic metabolomic approach combining nontargeted HPLC-ESI-QTOF-MS and targeted UFLC-ESI-MS/MS technologies were developed innovatively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183291
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http://dx.doi.org/10.1016/j.jpba.2019.04.009DOI Listing
April 2019
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Carbonic anhydrase activity as a potential biomarker for acute exposure to copper in corals.

Chemosphere 2019 Apr 15;227:598-605. Epub 2019 Apr 15.

Instituto Coral Vivo, Rua dos Coqueiros, Parque Yaya, Santa Cruz Cabrália, BA, 45807-000, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália, Km 8, Rio Grande, RS, 96203-900, Brazil. Electronic address:

Coral reefs are subjected to climate change and are severely impacted by human activities, with copper (Cu) being a relevant physiological stressor for corals at local scale. The ecological relevance of parameters measured at biochemical or cellular level is now considered an extremely important feature in environmental studies, and can be used as early warning signs of environmental degradation. In this context, the effects of acute exposure (96 h) to Cu were assessed on the maximum photochemical efficiency of zooxanthellae (Fv/Fm) and on the activity of key enzymes [carbonic anhydrase (CA) and Ca-ATPase] involved in coral physiology using the scleractinian coral Mussismilia harttii as a biological model. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.089DOI Listing

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.

Leuk Res 2019 Apr 13;81:43-49. Epub 2019 Apr 13.

University of Colorado Division of Hematology, Aurora, CO, United States. Electronic address:

Background: Patients with relapsed and refractory (R/R) acute myeloid leukemia (AML) have limited treatment options. Genomically-defined personalized therapies are only applicable for a minority of patients. Therapies without identifiable targets can be effective but patient selection is challenging. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.04.005DOI Listing

Corrigendum to "The moderating effect of perceived social support on the relation between heaviness of smoking and quit attempts among adult homeless smokers" [Drug and Alcohol Depend. 190 (2018) 128-132].

Drug Alcohol Depend 2019 Apr 19;199:69. Epub 2019 Apr 19.

The University of Oklahoma Health Sciences Center, Oklahoma Tobacco Research Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.003DOI Listing

Corrigendum to "Concurrent nicotine and tobacco product use among homeless smokers and associations with cigarette dependence and other factors related to quitting" [Drug Alcohol Depend. 185 (2018) 133-140].

Drug Alcohol Depend 2019 Apr 19;199:68. Epub 2019 Apr 19.

Oklahoma Tobacco Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.002DOI Listing

CRAC channels and disease - From human CRAC channelopathies and animal models to novel drugs.

Authors:
Stefan Feske

Cell Calcium 2019 Mar 11;80:112-116. Epub 2019 Mar 11.

Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA. Electronic address:

Ca release-activated Ca (CRAC) channels are intimately linked with health and disease. The gene encoding the CRAC channel, ORAI1, was discovered in part by genetic analysis of patients with abolished CRAC channel function. And patients with autosomal recessive loss-of-function (LOF) mutations in ORAI1 and its activator stromal interaction molecule 1 (STIM1) that abolish CRAC channel function and store-operated Ca entry (SOCE) define essential functions of CRAC channels in health and disease. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.03.004DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
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Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Bioprocess Engineering, Otto von Guericke University, Universitätsplatz 2, Magdeburg 39106, Germany. Electronic address:

Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory bowel diseases (IBD) of the gastrointestinal tract. This study used non-invasive LC-MS/MS to find disease specific microbial and human proteins which might be used later for an easier diagnosis. Therefore, 17 healthy controls, 11 CD patients and 14 UC patients but also 13 Irritable Bowel Disease (IBS) patients, 8 Colon Adenoma (CA) patients, and 8 Gastric Carcinoma (GCA) patients were investigated. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.009DOI Listing

Genetic Factors and Continental Ancestry Account for Some Disparities in Nonalcoholic Fatty Liver Disease Among Hispanic Subgroups.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.034DOI Listing

Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Boston Children's Hospital, Boston, MA. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) is commonly used to treat Clostridium difficile infection (CDI). CDI is an increasing cause of diarrheal illness in pediatric patients, but the effects of FMT have not been well studied in children. We performed a multi-center retrospective cohort study of pediatric and young adult patients to evaluate the efficacy, safety, and factors associated with a successful FMT for the treatment of CDI. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.037DOI Listing

Spatial Patterns From High-Resolution Electrogastrography Correlate With Severity of Symptoms in Patients With Functional Dyspepsia and Gastroparesis.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

GI Innovation Group, University of California-San Diego, La Jolla, CA, USA; GI Motility & Physiology Program, University of California-San Diego, La Jolla, CA, USA. Electronic address:

Background & Aims: Invasive gastric electrical mapping has revealed spatial abnormalities of the slow wave in subjects with gastroparesis and functional gastrointestinal disorders. Cutaneous high-resolution electrogastrography (HR-EGG) is a non-invasive method that can detect spatial features of the gastric slow wave. We performed HR-EGG in subjects with active foregut symptoms to evaluate associations between gastric myoelectric abnormalities, symptoms (based on a validated questionnaire), and gastric emptying. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.039DOI Listing

Should We Divide Crohn's Disease Into Ileum-dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

University of California San Diego, La Jolla CA.

Crohn's disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

At present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated "bad luck" theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalized medicine, are genome-obsessed and focused on identifying and targeting these mutated genes. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing

Possible drop metastasis after treatment of renal cell carcinoma with percutaneous cryoablation.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Division of Urology and Urologic Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.1016/j.urology.2019.04.010DOI Listing

Urinary and Sexual Outcomes following Bulbar Urethroplasty - An Analysis of Two Common Approaches.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Clinical Professor of Urology, University of California - Irvine, Department of Urology, 333 City Blvd West, Suite 1240, Orange, CA 92868. Electronic address:

Objective: To report success and patient reported urinary and sexual outcomes of patients who underwent anastomotic urethroplasty and dorsal buccal onlay urethroplasty.

Materials And Methods: Patients who underwent primary transecting anastomotic or dorsal buccal onlay urethroplasty for bulbar strictures at our institution between 1998 and 2015 were analyzed. Patients who had a prior urethroplasty, involvement of a different portion of the urethra, or a diagnosis of LS or hypospadias were excluded. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.042DOI Listing

A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

Thrombolysis for Management of Phlegmasia Cerulea Dolens in the First Trimester of Pregnancy.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.018DOI Listing

Laparoscopic Surgery in Chronic Mesenteric Ischaemia: Release of the Superior Mesenteric Artery from the Median Arcuate Ligament using the Transperitoneal Left Retrorenal Approach.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular and Thoracic Surgery, Hôpital Bichat, and SURVI (Structure d'URgences Vasculaires Intestinales), Intestinal Stroke Center, Groupe Hospitalier Universitaire Paris Nord Val de Seine (GHUPNVS), Faculté de Médecine Denis Diderot, Paris 7, France.

Median arcuate ligament (MAL) syndrome usually involves the celiac artery (CA) only. Far less frequently, both the CA and superior mesenteric artery (SMA) are compressed, leading to chronic mesenteric ischaemia. We report the case of a 46-year-old woman with a 4-year history of permanent nausea, postprandial abdominal pain and asthenia. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.009DOI Listing

Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Pediatric Pneumology and Allergology unit, Necker-Enfants Malades Hospital, Paris, France; Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1016/j.anai.2019.04.011DOI Listing

Impella use in acute myocardial infarction complicated by cardiogenic shock and cardiac arrest : Analysis of 10 years registry data.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193013
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.022DOI Listing
April 2019
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Analysis of genetic and clinical risk factors of post-transplant thrombocytopenia in kidney allograft recipients.

Transpl Immunol 2019 Apr 19. Epub 2019 Apr 19.

Western University of Health Sciences, Pomona, CA, United States; St. Vincent Medical Center, Los Angeles, CA, United States. Electronic address:

Background: Hematological abnormalities after transplantation are complications that may arise after renal transplantation, of which thrombocytopenia is associated with increased risk of bleeding and other complications. The development of thrombocytopenia is affected by various clinical conditions, and the stromal-derived factor 1 (SDF1) and platelet factor 4 (PF4) genes are known to be involved in the production or destruction of platelets. The purpose of this study was to investigate the prevalence of posttransplant thrombocytopenia and its association with other clinical conditions and genetic polymorphisms of SDF1 and PF4 genes a long time after transplantation. Read More

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http://dx.doi.org/10.1016/j.trim.2019.04.001DOI Listing
April 2019
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Experience-dependent mechanisms in the regulation of parental care.

Front Neuroendocrinol 2019 Apr 19. Epub 2019 Apr 19.

University of California, Davis, Department of Psychology, One Shields Ave. Davis, CA 95616.

Maternal behavior is a defining characteristic of mammals, which is regulated by a core, conserved neural circuit. However, mothering behavior is not always a default response to infant conspecifics. For example, initial fearful, fragmented or aggressive responses toward infants in laboratory rats and mice can give way to highly motivated and organized caregiving behaviors following appropriate hormone exposure or repeated experience with infants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00913022183012
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http://dx.doi.org/10.1016/j.yfrne.2019.04.002DOI Listing
April 2019
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Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

Blunt Curettage for Post-Operative Hematomas.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, University of California, Davis, Sacramento.

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http://dx.doi.org/10.1016/j.jaad.2019.04.031DOI Listing

Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca]i and mitochondrial fission/fusion.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. Electronic address:

This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's antagonizing the proliferation, Mdivi-1, DRP1 inhibitor, which has an inhibitory effect on mitochondrial fission, is used to compare with Mab. Cell viability was measured by either MTT or CCK-8. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.023DOI Listing

Development and Pilot Testing of an Assessment Tool for Performance of Invasive Mediastinal Staging.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

Thoracic Surgery, University of Alberta.

Background: To develop and evaluate a surgical trainee competency assessment instrument for invasive mediastinal staging, including cervical mediastinoscopy and endobronchial ultrasound (EBUS), a comprehensive instrument was developed utilizing expert review and simulated and clinical pilot-testing: Thoracic Competency Assessment Tool-Invasive Staging (TCAT-IS).

Methods: Validity and reliability evidence was collected and item analysis was performed. Initially, a 27-item instrument was developed, which underwent expert review with members of the Canadian Association of Thoracic Surgeons (n=86) in 2014-2015 (response rate 57%). Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.050DOI Listing

Improved Model Prediction of Glioma Growth Utilizing Tissue-Specific Boundary Effects.

Math Biosci 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Phoenix, AZ, USA.

Kinetic parameter estimates for mathematical models of glioblastoma multiforme (GBM), derived from clinical scans, have been used to predict the occurrence of hypoxia, necrosis, response to radiation therapy, and overall survival. Modeling GBM growth in a cerebral model encounters anatomical boundaries that interfere with model calibration from clinical measurements.

Methods: The effect of boundaries is examined on both spherically symmetric and anatomical models of tumor growth. Read More

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http://dx.doi.org/10.1016/j.mbs.2019.04.004DOI Listing

Validation and interpretation of short form 12 and comparison with dermatology life quality index in atopic dermatitis in adults.

J Invest Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Oregon Health & Science University, Portland, OR.

Quality of life (QOL) assessments are not standardized in atopic dermatitis (AD). We sought to determine the validity of Short-Form 12 (SF-12), a generic QOL assessment, in AD and compare its measurement properties with Dermatology Life Quality Index (DLQI). A cross-sectional, population-based study of 3495 adults was performed, including 602 that met a modified UK Working Party Criteria for AD. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1152DOI Listing

A reliable fluorimetric method to screen the nitric oxide synthase inhibitors in 96 well plate.

Anal Biochem 2019 Apr 19. Epub 2019 Apr 19.

Dr. BR Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110007, India. Electronic address:

In general, 4 amino-5-methylamino-2',7'-difluorescein diacetate (DAF-FM-DA) dye is used to detect nitric oxide in biological systems through cell imaging. In this study, we have used 96 well plate format to quantify nitric oxide using DAF-FM-DA through a multimode reader (or independently using fluorospectrometer) and could be visualized in fluorescence microscope. Similar study otherwise will require a high-end instrument. Read More

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http://dx.doi.org/10.1016/j.ab.2019.04.014DOI Listing

Refractive Laser-Assisted Cataract Surgery vs. Conventional Manual Surgery: Comparing Efficacy and Safety in 3144 Eyes.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Uptown Eye Specialists, Vaughan, Canada. Electronic address:

Purpose: To report on outcomes of efficacy and safety in one of the largest series of eyes undergoing either conventional manual cataract surgery (MCS) or refractive femtosecond laser-assisted cataract surgery (ReLACS).

Design: Retrospective, consecutive, interventional comparative case series.

Methods: This study included 3144 consecutive eyes of which 1580 were treated via MCS and 1564 were treated via ReLACS at Uptown Surgical Centre in Vaughan, Canada. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.010DOI Listing

Predictive factors of anemia during sofosbuvir and ribavirin therapy for genotype 2 chronic hepatitis C patients.

Hepatol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Aim: Sofosbuvir (SOF) and ribavirin (RBV) combination therapy has improved the sustained response rate (SVR) and shortened the treatment duration for patients with chronic HCV genotype 2 infection. RBV-induced hemolytic anemia is one of the most troublesome side effects of SOF/RBV therapy; however, factors associated with this condition have not been fully elucidated. We aimed to identify a safer way to complete treatment with SOF/RBV therapy by examining factors related to RBV-induced hemolytic anemia and identifying patients who did not develop anemia. Read More

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http://dx.doi.org/10.1111/hepr.13354DOI Listing

Relative Performance and Impacts of the Psyllid Arytinnis hakani (Hemiptera: Psyllidae) on Nontarget Plants and the Target Weed Genista monspessulana (Fabales: Fabaceae).

Environ Entomol 2019 Apr 22. Epub 2019 Apr 22.

Invasive Species and Pollinator Health Research Unit, USDA-ARS, Albany, CA.

No-choice tests can help select weed biological control agents with a high degree of host specificity but may exclude potentially effective agents that can develop on nontarget plants under laboratory conditions. The actual amount of damage to nontarget plants often goes unstudied, even though agents may exploit nontarget plants without inflicting significant harm. Furthermore, tests typically assess whether prospective agents can complete one generation on nontarget plants, and rarely examine whether agents are likely to persist on the nontarget plants over the long term. Read More

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http://dx.doi.org/10.1093/ee/nvz041DOI Listing

Six Month Abstinence Heterogeneity in the Best Quit Study.

Ann Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Understanding the characteristics of smokers who are successful in quitting may help to increase smoking cessation rates.

Purpose: To examine heterogeneity in cessation outcome at 6 months following smoking cessation behavioral counseling with or without weight management counseling.

Methods: 2,540 smokers were recruited from a large quitline provider and then randomized to receive proactive smoking cessation behavioral counseling without or with two versions of weight management counseling. Read More

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https://academic.oup.com/abm/advance-article/doi/10.1093/abm
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http://dx.doi.org/10.1093/abm/kaz014DOI Listing
April 2019
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Confidence boosts serial dependence in orientation estimation.

J Vis 2019 Apr;19(4):25

University of Wisconsin-Madison, Department of Psychology and Department of Psychiatry, Madison, WI.

In the absence of external feedback, a decision maker must rely on a subjective estimate of their decision accuracy in order to appropriately guide behavior. Normative models of perceptual decision-making relate subjective estimates of internal signal quality (e.g. Read More

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http://jov.arvojournals.org/article.aspx?doi=10.1167/19.4.25
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http://dx.doi.org/10.1167/19.4.25DOI Listing
April 2019
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Abundance and diversity of nitrogen-removing microorganisms in the UASB-anammox reactor.

PLoS One 2019 22;14(4):e0215615. Epub 2019 Apr 22.

College of Resources and Environmental Science, Xinjiang University, Urumqi, China.

Anaerobic ammonium oxidation is considered to be the most economical and low-energy biological nitrogen removal process. So far, anammox bacteria have not yet been purified from cultures. Some nitrogen-removing microorganisms cooperate to perform the anammox process. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215615PLOS

A priority based energy harvesting scheme for charging embedded sensor nodes in wireless body area networks.

PLoS One 2019 22;14(4):e0214716. Epub 2019 Apr 22.

Department of EECS, University of Tennessee, Knoxville, United States of America.

This research work proposes a novel priority aware schedule based charging algorithm that uses wireless power transfer (WPT) technique in order to charge embedded sensor nodes (SNs) in a wireless body area network (WBAN). Implanted sensor nodes in WBANs require energy for both information extraction and data transmission to the remote controller unit. Thus, energy shortage of these SNs deteriorates due to the data transmission process of the patient health monitoring system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214716PLOS

A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation.

PLoS Comput Biol 2019 Apr 22;15(4):e1006534. Epub 2019 Apr 22.

Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland.

Bacterial populations that colonize a host can play important roles in host health, including serving as a reservoir that transmits to other hosts and from which invasive strains emerge, thus emphasizing the importance of understanding rates of acquisition and clearance of colonizing populations. Studies of colonization dynamics have been based on assessment of whether serial samples represent a single population or distinct colonization events. With the use of whole genome sequencing to determine genetic distance between isolates, a common solution to estimate acquisition and clearance rates has been to assume a fixed genetic distance threshold below which isolates are considered to represent the same strain. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006534DOI Listing

BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data.

PLoS Comput Biol 2019 Apr 22;15(4):e1006971. Epub 2019 Apr 22.

Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Genome-scale metabolic models (GEMs) are mathematically structured knowledge bases of metabolism that provide phenotypic predictions from genomic information. GEM-guided predictions of growth phenotypes rely on the accurate definition of a biomass objective function (BOF) that is designed to include key cellular biomass components such as the major macromolecules (DNA, RNA, proteins), lipids, coenzymes, inorganic ions and species-specific components. Despite its importance, no standardized computational platform is currently available to generate species-specific biomass objective functions in a data-driven, unbiased fashion. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006971DOI Listing

Dermal Calcium Loss is Not the Primary Determinant of PTH Secretion during Exercise.

Med Sci Sports Exerc 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver, Aurora, CO.

Introduction: Exercise can cause a decrease in serum ionized calcium (iCa) concentration, which stimulates parathyroid hormone (PTH) secretion and activates bone resorption. We postulated that dermal Ca loss during cycling exercise is the major determinant of the serum iCa, PTH, and bone resorption (C-terminal telopeptide of type 1 collagen; CTX) responses.

Methods: To investigate this, women (n=13) and men (n=12) aged 18 to 45 years performed the same exercise bout under cool (18°C) and warm (26°C) conditions. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002017DOI Listing
April 2019
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Persistent Upper Lip Swelling in a Young Woman: Answer.

Am J Dermatopathol 2019 May;41(5):386-387

Departments of Dermatology, and.

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http://dx.doi.org/10.1097/DAD.0000000000001048DOI Listing

Machine Learning and Deep Neural Networks in Thoracic and Cardiovascular Imaging.

J Thorac Imaging 2019 May;34(3):192-201

Department of Radiology, University of California San Diego.

Advances in technology have always had the potential and opportunity to shape the practice of medicine, and in no medical specialty has technology been more rapidly embraced and adopted than radiology. Machine learning and deep neural networks promise to transform the practice of medicine, and, in particular, the practice of diagnostic radiology. These technologies are evolving at a rapid pace due to innovations in computational hardware and novel neural network architectures. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000385DOI Listing

Comment on "US FDA Breast Implant Postapproval Studies: Long-term Outcomes in 99,993 Patients".

Ann Surg 2019 Apr 18. Epub 2019 Apr 18.

Past President, American Society of Plastic Surgeons, Lenox Hill Hospital/Manhattan Eye, Ear, and Throat Hospital, Northwell Health System, Hofstra School of Medicine, New York, NY Past President, American Society for Aesthetic Plastic Surgery, Aesthetic Plastic Surgical Institute, Laguna Beach, CA; Loma Linda University, Loma Linda, CA Past President, American Society for Aesthetic Plastic Surgery, Private Practice, Eugene, OR Loma Linda University Medical Center, Loma Linda, CA.

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http://dx.doi.org/10.1097/SLA.0000000000003293DOI Listing
April 2019
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Local and Visiting Physician Perspectives on Short Term Surgical Missions in Guatemala: A Qualitative Study.

Ann Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, Stanford University, Stanford, CA.

Objective: To explore the impact of short-term surgical missions (STMs) on medical practice in Guatemala as perceived by Guatemalan and foreign physicians.

Summary Background Data: STMs send physicians from high-income countries to low and middle-income countries to address unmet surgical needs. Although participation among foreign surgeons has grown, little is known of the impact on the practice of foreign or local physicians. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003292DOI Listing

Assessment of Resistance in Potato Cultivars to Verticillium Wilt Caused by and .

Plant Dis 2019 Apr 19:PDIS10181815RE. Epub 2019 Apr 19.

4 Department of Plant Pathology, University of California, Davis, Salinas, CA 93905, U.S.A.

Verticillium wilt caused by spp., also called potato early dying disease, is one of the most serious soilborne diseases affecting potato production in China. The disease has been expanding into most potato production areas over the past few years. Read More

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https://apsjournals.apsnet.org/doi/10.1094/PDIS-10-18-1815-R
Publisher Site
http://dx.doi.org/10.1094/PDIS-10-18-1815-REDOI Listing
April 2019
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