1,397,287 results match your criteria CA: a cancer journal for clinicians[Journal]


LGBT youth in foster care and the critical advocacy role of Public Health Nurses.

Public Health Nurs 2020 Jun 4. Epub 2020 Jun 4.

School of Nursing, San Francisco State University, San Francisco, CA, USA.

Aims And Objectives: The purpose of this study was to describe the role of public health nurses working with lesbian, gay, bisexual, and transgender (LGBT) children in foster care in the San Francisco Bay Area.

Background: LGBT youth are disproportionately represented in foster care and experience poor health and education outcomes. Foster care public health nurses (FCPHN) are in a unique position to address disparities with timely and appropriate referrals and advocate for policy changes. Read More

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http://dx.doi.org/10.1111/phn.12757DOI Listing

Subspecies differentiation in an enigmatic chaparral shrub species.

Am J Bot 2020 Jun 4. Epub 2020 Jun 4.

University of California, Riverside, Riverside, CA, 92521.

Premise: Delimiting biodiversity units is difficult in organisms in which differentiation is obscured by hybridization, plasticity, and other factors that blur phenotypic boundaries. Such work is more complicated when the focal units are subspecies, the definition of which has not been broadly explored in the era of modern genetic methods. Eastwood manzanita (Arctostaphylos glandulosa Eastw. Read More

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http://dx.doi.org/10.1002/ajb2.1496DOI Listing

Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

San Raffaele Pisana Scientific Institute, Rome, Italy.

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has important implications for the safety of participants in clinical trials and the research staff caring for them and, consequently, for the trials themselves. Patients with heart failure may be at greater risk of infection with COVID-19 and the consequences might also be more serious, but they are also at risk of adverse outcomes if their clinical care is compromised. As physicians and clinical trialists, it is our responsibility to ensure safe and effective care is delivered to trial participants without affecting the integrity of the trial. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa461DOI Listing

Systematic manipulations of the biological stress systems result in sex-specific compensatory stress responses and negative mood outcomes.

Neuropsychopharmacology 2020 Jun 4. Epub 2020 Jun 4.

Faculty of Medicine, McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada.

Women are twice as likely as men to be diagnosed with anxiety and mood disorders. One potential underlying mechanism is sex differences in physiological and psychological responses to stress; however, no studies to date have investigated this proposed mechanism experimentally. In a double-blind, placebo-controlled design, pharmacological challenges were administered to individually suppress the hypothalamic-pituitary-adrenal (HPA) axis, or the sympathetic nervous system (SNS) prior to stress exposure, to investigate sex differences in the resulting cross talk among the physiological and psychological stress responses. Read More

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http://dx.doi.org/10.1038/s41386-020-0726-8DOI Listing

Ultrasound assisted wet media milling synthesis of nanofiber-cage LiFePO/C.

Ultrason Sonochem 2020 May 27;68:105177. Epub 2020 May 27.

Department of Chemical Engineering, Polytechnique Montréal, Québec, Canada. Electronic address:

To meet the objectives of the Intergovernmental Panel on Climate Change nations are adopting policies to encourage consumers to purchase electric vehicles. Electrification of the automobile industry reduces greenhouse gases but active metals for the cathode-LiCoO and LiNiO-are toxic and represent an environmental challenge at the end of their lifetime. LiFePO (LFP) is an attractive alternative that is non-toxic, thermally stable, and durable but with a moderate theoretical capacity and a low electrical conductivity. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105177DOI Listing

Pregnancy outcomes and postpartum relapse rates in women with RRMS treated with alemtuzumab in the phase 2 and 3 clinical development program over 16 years.

Mult Scler Relat Disord 2020 May 6;43:102146. Epub 2020 May 6.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is frequently diagnosed in women of reproductive age. Because the use of disease-modifying therapies (DMTs) early in the disease course is increasing, it is important to evaluate the safety of DMTs in pregnant women and their developing fetuses. Alemtuzumab, approved for the treatment of relapsing forms of MS, is administered as 2 courses of 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102146DOI Listing

Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis.

Gait Posture 2020 May 19;80:96-100. Epub 2020 May 19.

Division of Physical Medicine and Rehabilitation, Stanford University, Stanford, CA, United States.

Background: Functional ambulation limitations are features of lumbar spinal stenosis (LSS) and knee osteoarthritis (OA). With numerous validated walking assessment protocols and a vast number of spatiotemporal gait parameters available from sensor-based assessment, there is a critical need for selection of appropriate test protocols and variables for research and clinical applications.

Research Question: In patients with knee OA and LSS, what are the best sensor-derived gait parameters and the most suitable clinical walking test to discriminate between these patient populations and controls?

Methods: We collected foot-mounted inertial measurement unit (IMU) data during three walking tests (fast-paced walk test-FPWT, 6-min walk test- 6MWT, self-paced walk test - SPWT) for subjects with LSS, knee OA and matched controls (N = 10 for each group). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.019DOI Listing

Systemic therapy in metastatic renal cell carcinoma: Emerging challenges in therapeutic choice.

Crit Rev Oncol Hematol 2020 Jun 1;152:102971. Epub 2020 Jun 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada; Canadian Centre for Applied Research in Cancer Control, Toronto, Ontario, Canada. Electronic address:

The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone a substantial evolution in the past decade, with a dramatic increase in the number of available systemic therapies. Although this offers promise for improved patient outcomes, this rapid pace in development has led to new challenges in therapeutic choice. For instance, the absence of direct comparative evidence across all therapeutic options has led to a critical gap in evidence to clearly define preferred systemic therapy choice. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102971DOI Listing

Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids.

J Nutr Biochem 2020 Apr 30;83:108403. Epub 2020 Apr 30.

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China; Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA. Electronic address:

Glycolipid metabolism disorder is one of the causes of type 2 diabetes (T2D). Alternate-day fasting (ADF) is an effective dietary intervention to counteract T2D. The present study is aimed to determine the underlying mechanisms of the benefits of ADF metabolic on diabetes-induced glycolipid metabolism disorders in db/db mice. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108403DOI Listing

Columnar aerosol properties and radiative effects over Dushanbe, Tajikistan in Central Asia.

Environ Pollut 2020 May 25;265(Pt B):114872. Epub 2020 May 25.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China; Center for Excellence in Tibetan Plateau Earth Sciences, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

This paper presents the results of the study on columnar aerosol optical and physical properties and radiative effects directly observed over Dushanbe, the capital city of Tajikistan, a NASA AERONET site (equipped with a CIMEL sunphotometer) in Central Asia. The average aerosol optical depth (AOD) and Ångström exponent (AE) during the observation period from July 2010 to April 2018 were found to be 0.28 ± 0. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114872DOI Listing

Chemical and physical properties of nanocrystalline chitosan by the method: Modified nanochitosan complex and process of obtaining modified nanochitosan.

Carbohydr Res 2020 May 21;493:108035. Epub 2020 May 21.

Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande Do Sul - UFRGS, Porto Alegre, RS, Brazil.

Nanocrystalline chitosan (NCC) is a modified form of chitosan, prepared from the method for obtaining chitosan acetate (CA). Due to the greater crystallinity of chitosan nanoparticles in relation to CA, NCC is more thermally stable and thus has great potential in the development of a new generation of biomaterials potentially useful in regenerative medicine and tissue engineering. NCC is also characterized by having similar properties to its precursor chitosan, such as its biocompatibility, bioactivity, ability to be bioabsorbed and lack of toxicity. Read More

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http://dx.doi.org/10.1016/j.carres.2020.108035DOI Listing

Exposure to childhood interpersonal trauma and mental health service urgency.

Child Abuse Negl 2020 Jun 1;106:104464. Epub 2020 Jun 1.

University of Western Ontario, 1137 Western Road, London, Ontario, N6G 1G7, Canada.

Background: Children and youth with a history of maltreatment experience different developmental, psychiatric and health problems. Ensuring there is streamlined access to services is imperative to recovery. Yet, few reports of standardized methods for directing and prioritizing risk for children seeking services exist. Read More

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http://dx.doi.org/10.1016/j.chiabu.2020.104464DOI Listing

Teaching old precursors new tricks: Fast room temperature synthesis of surfactant-free colloidal platinum nanoparticles.

J Colloid Interface Sci 2020 May 25;577:319-328. Epub 2020 May 25.

University of Bern, Department of Chemistry and Biochemistry, Freiestrasse 3 CH-3012 Bern, Switzerland. Electronic address:

A fast, simple, instrument-free room temperature synthesis of stable electroactive surfactant-free colloidal Pt nanoparticles in alkaline methanol and methanol-water mixtures is presented. Pair distribution function (PDF) analysis suggests that methoxy substitution of chloride ligands from HPtCl occurs in methanol. X-ray absorption spectroscopy (XAS) studies and UV-vis measurements show that solutions of HPtCl in methanol age and are reduced to Pt(II) species over time. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.05.078DOI Listing

Outcomes in Kawasaki disease patients with coronary artery abnormalities at admission.

Am Heart J 2020 May 3;225:120-128. Epub 2020 May 3.

Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Previous studies demonstrated that coronary artery lesions (CALs) resulting from Kawasaki disease (KD) can improve over time. However, limited information is available on sub-acute outcomes of CALs detected at admission during KD illness.

Methods: The nationwide Japanese KD survey contained substantial information on KD patients with CALs detected at admission and who received standard IVIG treatment within 10 days of disease onset. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.019DOI Listing

Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause.

Neurobiol Aging 2020 Apr 29;94:1-6. Epub 2020 Apr 29.

Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Toronto, Ontario, Canada; Tema Genus, Linköping University, Linköping, Sweden.

Oophorectomy prior to menopause is associated with late-life dementia. Memory decline may start within 6 months after oophorectomy in middle-aged women, suggested by lower verbal and working memory performance. Unknown is whether such changes persist beyond 6 months, and whether they are reversed by estradiol. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.019DOI Listing

Perfluorinated compounds are not necessary: pegylated organosilanes can endow good water sliding/removal properties.

J Hazard Mater 2020 May 18;398:122625. Epub 2020 May 18.

National Institute of Advanced Industrial Science and Technology (AIST), 2266-98, Anagahora, Shimo-shidami, Moriyama, Nagoya 463-8560, Japan. Electronic address:

From a viewpoint of reducing the burden on both human health and the environment, alternative surface modification techniques for preparing highly water-repellent surfaces without the use of environmentally damaging perfluorocarbons are highly desirable. Among them, the development of hydrophilic surfaces showing superior water sliding/removal properties has been scarcely reported. In this study, we have successfully demonstrated the fabrication of smooth, transparent, and hydrophilic pegylated organosilanes (PEG-Si, CHO-(CHO)-CH-Si(OCH) where n = 3, 6-9, 9-12)-derived hybrid films showing excellent water sliding/removal properties using a simple sol-gel reaction of PEG-Si and tetraethoxysilane (TEOS, Si(OCH)). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122625DOI Listing

Effect of groundwater ions (Ca, Na, and HCO) on removal of hexavalent chromium by Fe(II)-phosphate mineral.

J Hazard Mater 2020 May 25;398:122948. Epub 2020 May 25.

Department of Civil and Environmental Engineering, Green Environment and Energy Lab., National Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, Kazakhstan. Electronic address:

A systematic study was conducted to investigate the effect of major groundwater ions (i.e., Ca, Na, and HCO) on removal of hexavalent chromium (Cr(VI)) by an Fe(II)-phosphate mineral (i. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122948DOI Listing

Low-current electro-oxidation enhanced the biodegradation of the recalcitrant naphthenic acids in oil sands process water.

J Hazard Mater 2020 May 19;398:122807. Epub 2020 May 19.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, T6G 2W2, Canada. Electronic address:

Combining electro-oxidation (EO) with biodegradation for real oil sands process water (OSPW) treatment was evaluated in terms of naphthenic acid (NA) biodegradation enhancement. Ion mobility spectrometry (IMS) qualitative analysis showed that EO by graphite was able to degrade the different NA clusters in OSPW including: classical, oxidized and heteroatomic NAs. Applying EO even at current density as low as 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122807DOI Listing

Assessment of Online Sites Reliability, Accountability, Readability, Accessibility and Translation for Intravitreal Injections.

Ophthalmol Retina 2020 Jun 1. Epub 2020 Jun 1.

Palo Alto Medical Foundation, Palo Alto, CA. Electronic address:

Purpose: Patients increasingly use the internet to access health-related information to further understand their treatments and conditions. This study compares the quality, accountability, readability, accessibility and presence of translation between private and academic online source material available to the public regarding intravitreal injections.

Design: Cross-sectional analysis PARTICIPANTS: Top 20 websites on a Google search for the terms 'eye injections', 'intravitreal injections' and 'anti-VEGF injections'. Read More

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http://dx.doi.org/10.1016/j.oret.2020.05.019DOI Listing

Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos.

Chemosphere 2020 May 27;257:127170. Epub 2020 May 27.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address:

Ammonia (including NH and NH) is a major pollutant of freshwater environments. However, the toxic effects of ammonia on the early stages of fish are not fully understood, and little is known about the effects on the sensory system. In this study, we hypothesized that ammonia exposure can cause adverse effects on embryonic development and impair the lateral line system of fish. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127170DOI Listing

Source apportionment and health risk assessment of airborne particulates over central Indo-Gangetic Plain.

Chemosphere 2020 May 22;257:127145. Epub 2020 May 22.

Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, India; DST-Mahamana Centre of Excellence in Climate Change Research, Banaras Hindu University, Varanasi, India. Electronic address:

Sources of airborne particulates (PM) were investigated in two contrasting sites over central Indo-Gangetic Plain (IGP), one representing a rural background (Mirzapur) and another as an urban pollution hotspot (Varanasi). Very high PM concentration was noted both in Varanasi (178 ± 105 μgm; N:435) and Mirzapur (131 ± 56 μgm; N:169) with 72% and 62% of monitoring days exceeded the national air quality standard, respectively. Particulate-bound elements contribute significant proportion of PM mass (15%-18%), with highest contribution from Ca (7%-10%) and Fe (2%-3%). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127145DOI Listing

Rivers of Indochina as potential drivers of lineage diversification in the spotted flying lizard (Draco maculatus) species complex.

Mol Phylogenet Evol 2020 Jun 1:106861. Epub 2020 Jun 1.

Department of Biology and M.I. Bean Life Science Museum, Brigham Young University, 150 East Bulldog Boulevard, Provo, UT, 84602; Department of Biology, Austin Peay State University, Clarksville, TN, 37044. Electronic address:

Southeast Asia hosts a rich concentration of biodiversity within multiple biodiversity hotspots. Indochina, a region with remarkably high levels of in situ diversification, possesses five major rivers (Chiang Mai, Ayeyarwady, Mekong, Salween, and Red), several of which coincide with phylogenetic breaks of terrestrial taxa. Draco maculatus possesses a range that stretches across Indochina, which widespread geographic distribution along with potential discrete variation within subspecies alludes to the possibility of this taxon constituting multiple divergent lineages. Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106861DOI Listing

A five-gene molecular phylogeny reveals Parapanteles Ashmead (Hymenoptera: Braconidae) to be polyphyletic as currently composed.

Mol Phylogenet Evol 2020 Jun 1:106859. Epub 2020 Jun 1.

Department of Entomology, University of Illinois Urbana-Champaign, Urbana IL 61801. Electronic address:

Parapanteles Ashmead (Braconidae: Microgastrinae) is a medium-sized genus of microgastrine wasps that was erected over a century ago and lacks a unique synapomorphic character, and its monophyly has not been tested by any means. Parapanteles usually are parasitoids of large, unconcealed caterpillars (macrolepidoptera) and have been reared from an unusually large diversity of hosts for a relatively small microgastrine genus. We used Cytochrome Oxidase I sequences ("DNA barcodes") available for Parapanteles and other microgastrines to sample the generic diversity of described and undescribed species currently placed in Parapanteles, and then sequenced four additional genes for this subsample (wingless, elongation factor 1-alpha, ribosomal subunit 28s, and NADH dehydrogenase subunit 1). Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106859DOI Listing

Funneled angle landscapes for helical proteins.

J Inorg Biochem 2020 May 11;208:111091. Epub 2020 May 11.

Department of Chemistry and Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711, United States of America. Electronic address:

We use crystallographic data for four helical iron proteins (cytochrome c-b, cytochrome c', sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states. From these data we construct an angle phase diagram to display the evolution of each protein from its native state; and, in turn, the phase diagram is used to construct a funneled angle landscape for comparison with the topography of its folding energy landscape. We quantify the departure of individual helical and turning regions from the areal, angular profile of corresponding regions of the native state. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111091DOI Listing

A crack in the wall: Chronic pain management in integrative group medical visits.

Soc Sci Med 2020 May 20;258:113061. Epub 2020 May 20.

Substance Use Disorders Treatment & Services Research, Department of Psychiatry, University of California, San Francisco, USA. Electronic address:

Amidst a national crisis of opioid overdose, substantial uncertainty remains over how to safely and effectively address chronic pain. In response to this crisis, safety-net primary care clinics are instituting integrative group medical visits (IGMVs) for chronic pain management. Through two qualitative studies of IGMVs, we found that these groups acted as workarounds implemented by clinicians seeking to innovate upon standard pain management protocols. Read More

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http://dx.doi.org/10.1016/j.socscimed.2020.113061DOI Listing

Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments.

J Inorg Biochem 2020 May 26;209:111122. Epub 2020 May 26.

Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland. Electronic address:

A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2'-bipyridine and 5-ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules rapidly liberating on average ca. 2. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111122DOI Listing

After the COVID 19 outbreak in Italy: What have we learnt?

Travel Med Infect Dis 2020 Jun 1:101761. Epub 2020 Jun 1.

Department of Biomedical Sciences for Health, University of Milan - ASST Fatebenefratelli - Sacco, Milan, Italy.

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http://dx.doi.org/10.1016/j.tmaid.2020.101761DOI Listing

Loss of Ventricular Pre-excitation During Non-invasive Testing Does Not Exclude High-Risk Accessory Pathways: A Multicenter Study of WPW in Children.

Heart Rhythm 2020 Jun 1. Epub 2020 Jun 1.

The Children's Hospital at Montefiore Medical Center, Bronx, NY.

Background: Abrupt loss of ventricular pre-excitation on non-invasive evaluation, or non-persistent pre-excitation, in Wolff-Parkinson-White syndrome (WPW) is thought to indicate a low risk of life-threatening events.

Objective: To compare accessory pathway (AP) characteristics and occurrences of sudden cardiac arrest (SCA) and rapidly conducted pre-excited atrial fibrillation (RC-AF) in patients with non-persistent and persistent pre-excitation.

Methods: Patients ≤21 years with WPW and invasive electrophysiology study (EPS) data, SCA, or RC-AF were identified from multicenter databases. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.05.035DOI Listing

NMDA receptors in visual and olfactory sensory integration in male long evans rats: a role for the orbitofrontal cortex.

Neuroscience 2020 Jun 1. Epub 2020 Jun 1.

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada. Electronic address:

Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory features to create a comprehensive representation of the environment. Integration of sensory input is necessary to achieve a coherent perception of the environment, and to subsequently plan and coordinate action. The neural mechanisms mediating SI are poorly understood; however, recent studies suggest that the regulation of SI involves N-methyl-D-aspartate receptors (NMDARs) in orbitofrontal cortex (OFC). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.05.041DOI Listing

Functional PVDF ultrafiltration membrane for Tetrabromobisphenol-A (TBBPA) removal with high water recovery.

Water Res 2020 May 18;181:115952. Epub 2020 May 18.

Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada; Institute for Energy, Environment and Sustainable Communities, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.

Tetrabromobisphenol-A (TBBPA) is one of the most important brominated flame retardants (BFRs), accounting for 60% of the total commercial BFR market. Increasing amounts of TBBPA and byproducts are released to the aquatic environment due to their extensive utilization in various sectors. However, research on the treatment of TBBPA contaminated wastewater using membrane filtration is still lacked. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115952DOI Listing

Special Communication: Evaluation and Treatment of Thoracic Outlet Syndrome During the Global Pandemic Due to SARS-CoV-2 and COVID-19.

J Vasc Surg 2020 Jun 1. Epub 2020 Jun 1.

The Center for Thoracic Outlet Syndrome and the Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO. Electronic address:

The global SARS-CoV-2/COVID-19 pandemic has required a reduction in non-emergency treatment for a variety of disorders. This report summarizes conclusions of an international multidisciplinary consensus group assembled to address evaluation and treatment of patients with thoracic outlet syndrome (TOS), a group of conditions characterized by extrinsic compression of the neurovascular structures serving the upper extremity. The following recommendations were developed in relation to the 3 defined types of TOS (neurogenic, venous, and arterial) and 3 phases of pandemic response (preparatory, urgent with limited resources, and emergency with complete diversion of resources): (1) In-person evaluation and treatment for neurogenic TOS (interventional or surgical) is generally postponed during all pandemic phases, with telephone/telemedicine visits and at-home physical therapy exercises recommended when feasible. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.048DOI Listing

Crayfish and Drosophila NMJs.

Neurosci Lett 2020 Jun 1:135110. Epub 2020 Jun 1.

Department of Biological Sciences, University at Albany, SUNY, Albany, NY 12222, United States. Electronic address:

Many synaptic studies have utilized the experimental advantages of the Arthropod NMJ and the most prominent preparations have been the crayfish and Drosophila larval NMJs. Early cellular studies in the crayfish established the framework for later molecular studies in Drosophila. The two neuromuscular systems are compared including the advantages presented by each preparation for cellular analysis. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135110DOI Listing

Modifications to Dermatology Residency Education During the COVID-19 Pandemic.

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Division of Dermatology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.106DOI Listing

Pulmonary embolism response teams in the challenging era of venous thromboembolism associated with COVID-19.

J Vasc Surg Venous Lymphat Disord 2020 Jun 1. Epub 2020 Jun 1.

Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center; Los Angeles, California; USA.

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http://dx.doi.org/10.1016/j.jvsv.2020.04.032DOI Listing

A data-driven network model for the emerging COVID-19 epidemics in Wuhan, Toronto and Italy.

Math Biosci 2020 Jun 1:108391. Epub 2020 Jun 1.

Lamps and Center of Disease Modelling (CDM), Department of Mathematics and Statistics, York University, Toronto, ON, M3J 1P3, Canada. Electronic address:

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic threatens the health of humans and causes great economic losses. Predictive modelling and forecasting the epidemic trends are essential for developing countermeasures to mitigate this pandemic. We develop a network model, where each node represents an individual and the edges represent contacts between individuals where the infection can spread. Read More

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http://dx.doi.org/10.1016/j.mbs.2020.108391DOI Listing

An explicitly multi-component arterial gas embolus dissolves much more slowly than its one-component approximation.

Math Biosci 2020 Jun 1:108393. Epub 2020 Jun 1.

Facultad de Ciencias Químicas, Benemérita Unversidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, 72570 Puebla, Mexico. Electronic address:

We worked out the growth and dissolution rates of an arterial gas embolism (AGE), to illustrate the evolution over time of its size and composition, and the time required for its total dissolution. We did this for a variety of breathing gases including air, pure oxygen, Nitrox and Heliox (each over a range of oxygen mole fractions), in order to assess how the breathing gas influenced the evolution of the AGE. The calculations were done by numerically integrating the underlying rate equations for explicitly multi-component AGEs, that contained a minimum of three (water, carbon dioxide and oxygen) and a maximum of five components (water, carbon dioxide, oxygen, nitrogen and helium). Read More

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http://dx.doi.org/10.1016/j.mbs.2020.108393DOI Listing

Enhanced Recovery After Cesarean Delivery: is protocol compliance the missing link?

Authors:
G Nelson R D Wilson

Am J Obstet Gynecol 2020 Jun 1. Epub 2020 Jun 1.

Department of Obstetrics & Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.ajog.2020.05.053DOI Listing

Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy.

Neuropharmacology 2020 Jun 1:108174. Epub 2020 Jun 1.

Graduate Program in Neuroscience, University of British Columbia, Canada; Department of Psychology, University of British Columbia, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada. Electronic address:

Perinatal depression (PND) affects approximately 15% of women, and de novo postpartum depression affects approximately 40% of PND cases. Selective serotonin reuptake inhibitors (SSRIs) are a common class of antidepressants prescribed to treat PND. However, the safety and efficacy of SSRIs have been questioned in both clinical and preclinical research. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108174DOI Listing

Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis.

Comp Biochem Physiol B Biochem Mol Biol 2020 Jun 1:110461. Epub 2020 Jun 1.

Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa K1S 5B6, Canada. Electronic address:

In arid conditions, the African Clawed frog Xenopus laevis enters a state of estivation dormancy as an adaptive survival strategy. Under estivation, X. laevis experience severe dehydration stress as 25-35% of total body water is lost. Read More

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http://dx.doi.org/10.1016/j.cbpb.2020.110461DOI Listing

Clinical history and management of bicuspid aortic valve in children and adolescents.

Prog Cardiovasc Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, United States of America; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Bicuspid aortic valve (BAV) is one of the most common congenital heart defects in children, adolescents and adults. BAV can occur as an isolated lesion or in association with other congenital heart defects, such as coarctation of the aorta or genetic syndromes like Turner syndrome. Although the majority of long term complications associated with BAV manifest later in life, children and adolescents may present with early onset valvular dysfunction or dilation of the aorta. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.05.012DOI Listing

Pseudoaneurysm formation following myocarditis: a rare cause of a systolic murmur.

Can J Cardiol 2020 Jun 1. Epub 2020 Jun 1.

Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

A 49-year-old male was diagnosed myopericarditis following an episode of pleuritic chest pain. He underwent coronary angiography, which was unremarkable. He presented a year later with shortness of breath and chest pain. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.05.019DOI Listing

Outcomes and complications of immediate versus delayed sequential bilateral cataract surgery in children.

J AAPOS 2020 Jun 1. Epub 2020 Jun 1.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: To present the largest series to date comparing outcomes and complications of immediate versus delayed sequential bilateral cataract surgery (ISBCS vs DSBCS) in children at a single center over a 10-year period.

Methods: The medical records of children <2 years of age who underwent ISBCS and DSBCS were reviewed retrospectively. Data was collected on outcomes and complications (ophthalmological and anesthesia-related) up to 8 weeks postoperatively. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.02.009DOI Listing

Coronary angiography and percutaneous coronary intervention after transcatheter aortic valve replacement with medtronic self-expanding prosthesis: Insights from correlations with computer tomography.

Int J Cardiol 2020 Jun 1. Epub 2020 Jun 1.

Division of Cardiology, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America. Electronic address:

Objectives: We aim to describe the feasibility, challenges, success rates and techniques utilized in coronary angiography (CA) and percutaneous coronary intervention (PCI) in patients post transcatheter aortic valve replacement (TAVR).

Background: CA and PCI after TAVR are becoming increasingly encountered in clinical practice. There have been technical difficulties reported in re-accessing the coronary arteries through the self-expanding CoreValve prosthesis. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.05.065DOI Listing

Attention control and the attention schema theory of consciousness.

Prog Neurobiol 2020 Jun 1:101844. Epub 2020 Jun 1.

Department of Psychology, Princeton University, Princeton, NJ 08544, United States. Electronic address:

In the attention schema theory (AST), the brain constructs a schematic, simplified model of attention. The model is associated with three cognitive processes: a model of one's own attention contributes to the endogenous control of attention, a model of the attention of others contributes to theory of mind, and the contents of these models leads to the common human claim that we contain a non-physical consciousness or awareness inside us. Because AST is a control-engineering style theory, it can make specific predictions in complex situations. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2020.101844DOI Listing

Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?

Front Neuroendocrinol 2020 Jun 1:100849. Epub 2020 Jun 1.

Department of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. Electronic address:

Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for microbiota-brain communication in brain development, behavior, and brain function over the life span, clinical studies have started to consider the microbiome in psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.yfrne.2020.100849DOI Listing

Effects of high fructose corn syrup on ethanol self-administration in rats.

Alcohol 2020 Jun 1. Epub 2020 Jun 1.

Department of Psychology, University of Guelph (ON). Electronic address:

Objective: the addition of sweeteners to alcoholic beverages is thought to facilitate heavy alcohol consumption, and this may be of particular concern when the additive is high fructose corn syrup (HFCS).

Methods: four experiments in male Sprague-Dawley rats were performed to investigate whether the addition of 25% HFCS to ethanol (5%, 10% & 20% v/v EtOH) would alter its intraoral operant self-administration, palatability, and sensitivity to food deprivation stress.

Results: as anticipated, HFCS drastically increased EtOH intake, and this effect appeared driven by its caloric value. Read More

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http://dx.doi.org/10.1016/j.alcohol.2020.05.003DOI Listing

Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa.

Mol Ther 2020 May 20. Epub 2020 May 20.

Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA. Electronic address:

Systemic skin-selective therapeutics would be a major advancement in the treatment of diseases affecting the entire skin, such as recessive dystrophic epidermolysis bullosa (RDEB), which is caused by mutations in the COL7A1 gene and manifests in transforming growth factor-β (TGF-β)-driven fibrosis and malignant transformation. Homing peptides containing a C-terminal R/KXXR/K motif (C-end rule [CendR] sequence) activate an extravasation and tissue penetration pathway for tumor-specific drug delivery. We have previously described a homing peptide CRKDKC (CRK) that contains a cryptic CendR motif and homes to angiogenic blood vessels in wounds and tumors, but it cannot penetrate cells or tissues. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.05.017DOI Listing

Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis.

Lancet 2020 Jun 1. Epub 2020 Jun 1.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Michael G DeGroote Cochrane Canada and GRADE Centres, Hamilton, ON, Canada. Electronic address:

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is spread person-to-person through close contact. We aimed to investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.

Methods: We did a systematic review and meta-analysis to investigate the optimum distance for avoiding person-to-person virus transmission and to assess the use of face masks and eye protection to prevent transmission of viruses. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)31142-9DOI Listing

Salty Taste: From Transduction to Transmitter Release, Hold the Calcium.

Authors:
Emily R Liman

Neuron 2020 Jun;106(5):709-711

Department of Biological Sciences, Section of Neurobiology, University of Southern California, 3641 Watt Way, Los Angeles, CA 90089, USA. Electronic address:

Detection of NaCl by the gustatory system is fundamental for salt intake and tissue homeostasis. Yet, signal transduction mechanisms for salty taste have remained obscure. In this issue of Neuron, Nomura et al. Read More

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http://dx.doi.org/10.1016/j.neuron.2020.05.012DOI Listing

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.

Cell 2020 May 22. Epub 2020 May 22.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address:

The rise of antibiotic resistance and declining discovery of new antibiotics has created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism of action (MoA) with undetectably low resistance frequencies. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.005DOI Listing
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