1,296,776 results match your criteria CA: a cancer journal for clinicians[Journal]


Proposed endocrine funding priorities for the NICHD strategic plan: expert opinion from the Pediatric Endocrine Society.

Pediatr Res 2019 Apr 17. Epub 2019 Apr 17.

Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41390-019-0401-0
Publisher Site
http://dx.doi.org/10.1038/s41390-019-0401-0DOI Listing
April 2019
1 Read

Tunable spin-state bistability in a spin crossover molecular complex.

J Phys Condens Matter 2019 Apr 17. Epub 2019 Apr 17.

Department of Physics and Astronomy and Center for Materials Research and Analysis, University of Nebraska- Lincoln, Jorgensen Hall, 855 North 16th Str., NE 68588-0299, Lincoln, 68588-0299, UNITED STATES.

The spin crossover (SCO) transitions at both the surface and over the entire volume of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] polycrystalline films on Al2O3 substrates have been studied, where pz = pyrazol-1-yl and bipy = 2,2'-bipyridine. For [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] films of hundreds of nm thick, magnetometry and x-ray absorption spectroscopy measurements show thermal hysteresis in the SCO transition with temperature, although the transition in bulk [Fe{H2B(pz)2}2(bipy)] occurs in a non-hysteretic fashion at 157 K. While the size of the crystallites in those films are similar, the hysteresis becomes more prominent in thinner films, indicating a significant effect of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)]/Al<sub>2</sub>O<sub>3</sub> interface. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-648X/ab1a7d
Publisher Site
http://dx.doi.org/10.1088/1361-648X/ab1a7dDOI Listing
April 2019
1 Read
2.346 Impact Factor

Revelation of microalgae's lipid production and resistance mechanism to ultra-high Cd stress by integrated transcriptome and physiochemical analyses.

Environ Pollut 2019 Apr 8;250:186-195. Epub 2019 Apr 8.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address:

The ultra-high Cd polluted environment is a special habitat in nature. Analysis of the biological adaptation and resistance mechanism of Auxenochlorella protothecoides UTEX234 to ultra-high Cd stress would offer some inspiring understanding on Cd detoxification mechanism and help discovering highly active bioremediation agents. In this study, integrated analyses of the transcriptome, multi-physiological and biochemical data and fatty acid profilings of UTEX2341 were performed for the first time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.04.018DOI Listing

Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca-ATPase.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

State Key Laboratory of Natural Medicines and Department of Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

Schefflera kwangsiensis Merr. ex H.L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.04.005DOI Listing

Optimal oxygenation and role of free radicals in PPHN.

Free Radic Biol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USA. Electronic address:

Effective ventilation of the lungs is essential in mediating pulmonary vasodilation at birth to allow effective gas exchange and an increase in systemic oxygenation. Unsuccessful transition prevents the increase in pulmonary blood flow after birth resulting in hypoxemia and persistent pulmonary hypertension of the newborn (PPHN). Management of neonates with PPHN includes ventilation of the lungs with supplemental oxygen to correct hypoxemia. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08915849193023
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.001DOI Listing
April 2019
6 Reads

Reactive oxygen species as mediators of oxygen signaling during fetal-to-neonatal circulatory transition.

Free Radic Biol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Reactive oxygen species (ROS) are frequently seen as pathological agents of oxidative stress. However, ROS are not always deleterious and can also act as cell signaling molecules. Vascular oxygen sensing and signaling during fetal-to-neonatal circulatory transition is a remarkable example of the physiological regulatory actions of ROS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.008DOI Listing

Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options.

Neurosci Biobehav Rev 2019 Apr 14. Epub 2019 Apr 14.

Island Medical Program, University of British Columbia, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada. Electronic address:

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), and has a significant impact on the increasing burden of these neuropathologies. Over the past decades, some of the pathophysiological and molecular mechanisms that contribute to these diseases have been elucidated and these findings indicate that, despite presenting distinct features, there are several similarities between the neurobiological alterations that lead to MDD and neurodegeneration in AD, PD and HD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neubiorev.2019.04.002DOI Listing

The Cytokines of Asthma.

Immunity 2019 Apr;50(4):975-991

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA.

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.03.018DOI Listing

The IL-17 Family of Cytokines in Health and Disease.

Immunity 2019 Apr;50(4):892-906

Division of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 anniversary of its discovery. Although less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.03.021DOI Listing

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation.

Immunity 2019 Apr;50(4):871-891

Laboratory of Immunoregulation and Infection, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

Cytokines are among the most important effector and messenger molecules in the immune system. They profoundly participate in immune responses during infection and inflammation, protecting against or contributing to diseases such as allergy, autoimmunity, and cancer. Manipulating cytokine pathways, therefore, is one of the most effective strategies to treat various diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.03.020DOI Listing

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

Cell Rep 2019 Apr;27(3):971-986.e9

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 approaches in patient-derived GBM stem cells (GSCs) to interrogate function of the coding genome, we identify actionable pathways responsible for growth, which reveal the gene-essential circuitry of GBM stemness and proliferation. In particular, we characterize members of the SOX transcription factor family, SOCS3, USP8, and DOT1L, and protein ufmylation as important for GSC growth. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193036
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.03.047DOI Listing
April 2019
1 Read

PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation.

Cell Rep 2019 Apr;27(3):793-805.e4

Department of Pharmacology and Centre for Lung and Vascular Biology, University of Illinois, College of Medicine, Chicago, IL, USA. Electronic address:

Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM inflammatory signaling and prevent lethal edema, the hallmark of acute lung injury (ALI), remain unknown. Here, we demonstrate the essential role of AM protease-activating receptor 2 (PAR2) in rapidly suppressing inflammation to prevent long-lasting injury. We show that thrombin, released during TLR4-induced lung injury, directly activates PAR2 to generate cAMP, which abolishes Ca entry through the TRPV4 channel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.053DOI Listing

The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression.

Cell Rep 2019 Apr;27(3):776-792.e7

Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target selectivity during host shutoff remain poorly understood. Using transcriptome-wide and targeted reporter experiments, we demonstrate that the influenza A virus endoribonuclease PA-X usurps RNA splicing to selectively target host RNAs for destruction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.063DOI Listing

Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment.

Cell Rep 2019 Apr;27(3):658-665.e4

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Program in Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

CaMKIIα is a central mediator of bidirectional synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). To study how CaMKIIα movement during plasticity is affected by soluble amyloid-β peptide oligomers (Aβ), we used FingR intrabodies to simultaneously image endogenous CaMKIIα and markers for excitatory versus inhibitory synapses in live neurons. Aβ blocks LTP-stimulus-induced CaMKIIα accumulation at excitatory synapses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.041DOI Listing

Induction of EGFP expression in Pichia pastoris during co-culture with human endothelial cell line.

J Microbiol Methods 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, 155 Fifth Street, San Francisco, CA 94103.

While Pichia pastoris has been developed into a versatile recombinant protein expression system, there are only few studies that have investigated the efficacious use of this yeast with human cells. In this study, we demonstrated that P. pastoris can be cultured under mammalian cell culture conditions and co-cultured with human endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mimet.2019.04.006DOI Listing

Sex-specific differences in adult cognition and neuroplasticity following repeated combinatory stress and TrkB receptor antagonism in adolescence.

Horm Behav 2019 Apr 14. Epub 2019 Apr 14.

Behavioral Neuroscience Group, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, Canada. Electronic address:

Evidence supports brain-derived neurotrophic factor (BDNF) and its primary receptor tyrosine-related kinase B (TrkB) as targets in the treatment of mood disorders. This study characterized the impact of a 10-day combinatory stress paradigm (alternating days of restraint stress and forced swim) and administration of the selective TrkB antagonist ANA-12 (0.5 mg/kg, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yhbeh.2019.04.006DOI Listing

Expanding Knowledge of the Host Range of and Host Plant Preference of MEAM1.

Plant Dis 2019 Apr 17:PDIS11181941RE. Epub 2019 Apr 17.

2 United States Department of Agriculture-Agricultural Research Service, Salinas, CA, U.S.A.

The crinivirus (ToCV) is often found infecting tomato crops in Brazil, with variable incidence, but associated with prevalence of its primary vector, MEAM1. ToCV control is difficult because there are no resistant commercial tomato varieties or hybrids available and chemical spray for control of the whitefly vector has not been effective. The present study evaluated the partial host range of a Brazilian isolate of ToCV and the preference of MEAM1 for oviposition on those species identified as susceptible to the virus. Read More

View Article

Download full-text PDF

Source
https://apsjournals.apsnet.org/doi/10.1094/PDIS-11-18-1941-R
Publisher Site
http://dx.doi.org/10.1094/PDIS-11-18-1941-REDOI Listing
April 2019
1 Read

Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy. Reply.

N Engl J Med 2019 Apr;380(16)

University of California, Los Angeles, Los Angeles, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1805100DOI Listing

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 Apr;380(16):1585

McGill University, Montreal, QC, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

A Belmont Report for Health Data.

N Engl J Med 2019 Apr;380(16):1493-1495

From the Moritz College of Law and the College of Public Health, Ohio State University, Columbus (E. Parasidis); the Office of the Chief Information Officer, Department of Health and Human Services, Washington, DC (E. Pike); and Ciitizen, Palo Alto, CA (D.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp1816373DOI Listing

Oral Ketamine for Depression: A Systematic Review.

J Clin Psychiatry 2019 Apr 16;80(3). Epub 2019 Apr 16.

Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Intravenous (IV) ketamine has rapid and robust antidepressant effects; however, poor accessibility of the IV route often limits its use. Numerous alternative routes of administration are being investigated. Oral ketamine is particularly appealing for its ease of use with the potential for high accessibility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4088/JCP.18r12475DOI Listing
April 2019
1 Read

Commentary on: Rehabilitation of the Dysmorphic Lower Eyelid From Hyaluronic Acid Filler: What to Do After a Good Periocular Treatment Goes Bad.

Aesthet Surg J 2019 Apr 17. Epub 2019 Apr 17.

Dr Goldberg is a Professor of Ophthalmology, David Geffen School of Medicine at UCLA; and Chief, Orbital and Ophthalmic Plastic Surgery Division, UCLA Stein Eye Institute, Los Angeles, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/asj/sjz084DOI Listing

Commentary on: Sub-Scarpa's Lipectomy in Abdominoplasty: An Analysis of Risks and Rewards in 723 Consecutive Patients.

Aesthet Surg J 2019 Apr 17. Epub 2019 Apr 17.

Dr Rosenfield is a Professor of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco (UCSF), San Francisco, CA; and an Adjunct Clinical Professor, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/asj/sjz085DOI Listing

Differences in Tsimane children's growth outcomes and associated determinants as estimated by WHO standards vs. within-population references.

PLoS One 2019 17;14(4):e0214965. Epub 2019 Apr 17.

Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, United States of America.

Anthropometric measures are commonly converted to age stratified z-scores to examine variation in growth outcomes in mixed-age and sex samples. For many study populations, z-scores will differ if calculated from World Health Organization (WHO) growth standards or within-population references. The specific growth reference used may influence statistical estimates of growth outcomes and their determinants, with implications for biological inference. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214965PLOS

Response of grassland ecosystem to monsoonal precipitation variability during the Mid-Late Holocene: Inferences based on molecular isotopic records from Banni grassland, western India.

PLoS One 2019 17;14(4):e0212743. Epub 2019 Apr 17.

Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.

Banni, located in the arid western India, is one of the largest tropical grasslands of the Asian continent. The net primary production in this grassland ecosystem is currently mediated by precipitation during the Indian summer monsoon (ISM). However, timing of the grassland expansion and its link to the intensity of monsoonal precipitation remains enigmatic due to the paucity of datasets. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212743PLOS

Putative parapoxvirus-associated foot disease in the endangered huemul deer (Hippocamelus bisulcus) in Bernardo O'Higgins National Park, Chile.

PLoS One 2019 17;14(4):e0213667. Epub 2019 Apr 17.

One Health Institute, School of Veterinary Medicine, University of California, Davis, CA, United States of America.

The huemul (Hippocamelus bisulcus) is an endangered cervid endemic to southern Argentina and Chile. Here we report foot lesions in 24 huemul from Bernardo O'Higgins National Park, Chile, between 2005 and 2010. Affected deer displayed variably severe clinical signs, including lameness and soft tissue swelling of the limbs proximal to the hoof or in the interdigital space, ulceration of the swollen tissues, and some developed severe proliferative tissue changes that caused various types of abnormal wear, entrapment, and/or displacement of the hooves and/or dewclaws. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213667PLOS

Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia.

J Clin Oncol 2019 Apr 17:JCO1801460. Epub 2019 Apr 17.

18 Ulm University, Ulm, Germany.

Purpose: A randomized, double-blind, phase III study of idelalisib (IDELA) plus rituximab versus placebo plus rituximab in patients with relapsed chronic lymphocytic leukemia (CLL) was terminated early because of superior efficacy of the IDELA-plus-rituximab (IDELA/R) arm. Patients in either arm could then enroll in an extension study to receive IDELA monotherapy. Here, we report the long-term efficacy and safety data for IDELA-treated patients across the primary and extension studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.18.01460DOI Listing

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.

J Clin Oncol 2019 Apr 17:JCO1801575. Epub 2019 Apr 17.

17 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The primary objective was to determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival (RFS) compared with pelvic radiation therapy (RT) in high-intermediate and high-risk early-stage endometrial carcinoma.

Patients And Methods: A randomized phase III trial was performed in eligible patients with endometrial cancer. Eligible patients had International Federation of Gynecology and Obstetrics (2009) stage I endometrioid histology with Gynecologic Oncology Group protocol 33-based high-intermediate-risk criteria, stage II disease, or stage I to II serous or clear cell tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.18.01575DOI Listing

Identifying Developmental Language Disorder in Vietnamese Children.

J Speech Lang Hear Res 2019 Apr 17:1-16. Epub 2019 Apr 17.

San Diego State University, CA.

Purpose Developmental language disorder (DLD), defined by low language performance despite otherwise normal development, can negatively impact children's social and academic outcomes. This study is the 1st to examine DLD in Vietnamese. To lay the foundation, we identified cases of DLD in Vietnam and explored language-specific characteristics of the disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1044/2019_JSLHR-L-18-0305DOI Listing

A bipartite begomovirus infecting (family ) in the Dominican Republic represents a distinct phylogenetic lineage and has a high degree of host specificity.

Phytopathology 2019 Apr 17. Epub 2019 Apr 17.

University of California, Davis, Department of Plant Pathology , 1 Shields Ave , Davis, California, United States , 95616 ;

plants in and around agricultural fields in the Azua Valley of the southeastern Dominican Republic often show striking golden mosaic symptoms. Leaf samples from plants showing these symptoms were collected in 2012 and 2013, and PCR tests with degenerate primers revealed begomovirus DNA-A and DNA-B components. The complete sequences of the DNA-A and DNA-B components of four isolates show high degree of sequence identity (>96%), and a genome organization typical of New World (NW) bipartite begomoviruses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1094/PHYTO-02-19-0061-RDOI Listing

Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1).

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Neuroscience and Mental Health Institute and Dept. of Pharmacology, University of Alberta, Canada.

Peripheral nerve injury elicits an enduring increase in the excitability of the spinal dorsal horn. This change, which contributes to the development of neuropathic pain, is a consequence of release and prolonged exposure of dorsal horn neurons to various neurotrophins and cytokines. We have shown in rats that nerve injury increases excitatory synaptic drive to excitatory neurons but decreases drive to inhibitory neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00839.2018DOI Listing

Role of KASH domain lengths in the regulation of LINC complexes.

Mol Biol Cell 2019 Apr 17:mbcE19020079. Epub 2019 Apr 17.

Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, United States.

The LINC complex is formed by the conserved interactions between SUN and KASH domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. For example, In , SUN protein UNC-84 binds to two KASH proteins UNC-83 and ANC-1 to mediate nuclear migration and anchorage, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E19-02-0079DOI Listing

Tumour expressions of hypoxic markers predict the response to neo-adjuvant chemotherapy in children with inoperable rhabdomyosarcoma.

Biomarkers 2019 Apr 17:1-31. Epub 2019 Apr 17.

a Department of Paediatrics, Haematology and Oncology , Medical University of Gdansk , Poland.

Objective The study was to assess whether tumour expressions of hypoxia-inducible factor (HIF)-1α, glucose transporter (GLUT)-1, carbonic anhydrase (CA)IX and vascular endothelial growth factor (VEGF) predict response to neo-adjuvant chemotherapy (naCHT) in children with inoperable rhabdomyosarcoma (RMS). Methods Immunohistochemical expressions of hypoxia markers were determined semi-quantitatively in tumour tissue microarray of 46 patients with embryonal RMS (RME) and 20 with alveolar (RMA), treated with CWS protocols (1992-2013). Results In paediatric RME, response to naCHT was influenced significantly by tumour expression of CA IX and GLUT-1. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1
Publisher Site
http://dx.doi.org/10.1080/1354750X.2019.1606275DOI Listing
April 2019
1 Read

Detection and Localization of Prostate Cancer at 3-T Multiparametric MRI Using PI-RADS Segmentation.

AJR Am J Roentgenol 2019 Apr 17:W1-W10. Epub 2019 Apr 17.

3 Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

The purpose of this study is to determine the overall and sector-based performance of 3-T multiparametric MRI for prostate cancer (PCa) detection and localization by using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) scoring and segmentation compared with whole-mount histopathologic analysis. Multiparametric 3-T MRI examinations of 415 consecutive men were compared with thin-section whole-mount histopathologic analysis. A genitourinary radiologist and pathologist collectively determined concordance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2214/AJR.18.20113DOI Listing

Quantitative MRI Musculoskeletal Techniques: An Update.

AJR Am J Roentgenol 2019 Apr 17:1-10. Epub 2019 Apr 17.

1 Department of Radiology, University of California, San Diego Medical Center, San Diego, CA.

For many years, MRI of the musculoskeletal system has relied mostly on conventional sequences with qualitative analysis. More recently, using quantitative MRI applications to complement qualitative imaging has gained increasing interest in the MRI community, providing more detailed physiologic or anatomic information. In this article, we review the current state of quantitative MRI, technical and software advances, and the most relevant clinical and research musculoskeletal applications of quantitative MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2214/AJR.19.21143DOI Listing

Production of l-Ribulose Using an Encapsulated l-Arabinose Isomerase in Yeast Spores.

J Agric Food Chem 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , Wuxi , Jiangsu 214122 , People's Republic of China.

The rare sugar l-ribulose is produced from the abundant sugar l-arabinose by enzymatic conversion. An l-arabinose isomerase (AI) from Geobacillus thermodenitrificans was efficiently expressed and encapsulated in Saccharomyces cerevisiae spores. Deletion of the yeast OSW2 gene, which causes a mild defect in the integrity of the spore wall, substantially improved the activity of encapsulated AI, without damaging its superior enzymatic properties of thermostability, pH tolerance,and resistance toward SDS and proteinase treatments. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.jafc.9b00640
Publisher Site
http://dx.doi.org/10.1021/acs.jafc.9b00640DOI Listing
April 2019
1 Read

The genetic relationship between alcohol consumption and aspects of problem drinking in an ascertained sample.

Alcohol Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Background: Genome-wide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples.

Methods: In 6,731 European-Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol-related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the self-rating of effects of ethanol questionnaire (SRE-T), DSM-IV alcohol dependence (DSM4AD), DSM-5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an SNP (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.14064
Publisher Site
http://dx.doi.org/10.1111/acer.14064DOI Listing
April 2019
2 Reads

H-index and Academic Medicine.

Am J Clin Pathol 2019 Apr 17. Epub 2019 Apr 17.

Biomedical Branch Library University of British Columbia Vancouver, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqz037DOI Listing

Impact of abstinence and of reducing illicit drug use without abstinence on HIV viral load.

Clin Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, WA.

Background: Substance use is common among people living with HIV (PLWH) and a barrier to achieving viral suppression.

Objective: Among PLWH who report illicit drug use, we evaluated associations between HIV viral load (VL) and reduced use of illicit opioids, methamphetamine/crystal, cocaine/crack, and marijuana, regardless of whether or not abstinence was achieved.

Design: Longitudinal cohort studySetting/participantsPLWH in clinical care at 8 HIV clinics or 5 clinical studies. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciz299DOI Listing
April 2019
1 Read

The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):43-50. Epub 2019 Apr 11.

Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran.

Introduction: Long-term psychodynamic psychotherapy (LTPP) emphasizes the centrality of intrapsychic and unconscious conflicts and their relation to development. Although there is evidence supporting the efficacy of LTPP in mental disorders, little research has been published on the efficacy of LTPP for depressive and anxiety disorders.

Objective: To examine whether patients with anxiety and depressive disorders demonstrate improvement in their attachment styles, defense styles, psychiatric symptoms, anxiety/depressive symptoms, and alexithymia with LTPP. Read More

View Article

Download full-text PDF

Source
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/2237-6089-2017-0144DOI Listing
April 2019
1 Read

Cyclic fatigue resistance of novel Genius and Edgefile nickel-titanium reciprocating instruments.

Braz Oral Res 2019 11;33:e028. Epub 2019 Apr 11.

Universidade Estadual Paulista- UNESP, Araçatuba School of Dentistry, Department of Endodontics, Araçatuba, SP, Brazil.

This study aimed to assess the cyclic fatigue resistance of Genius and EdgeFile X1 reciprocating instruments compared with WaveOne Gold Primary. Twenty Genius (Ultradent) 25.04, 20 Genius 30. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0028DOI Listing

The role of computer-assisted structure elucidation (CASE) programs in the structure elucidation of complex natural products.

Nat Prod Rep 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.

Covering: up to the end of December, 2018There are still a disturbing number of incorrect natural product structure elucidations reported in the literature. The use of Computer-Assisted Structure Elucidation (CASE) programs can minimize this risk by generating all structures that are consistent with the input data and by ranking these structures in order of probability. They can successfully determine structures for complex natural products, with the possible exception of compounds with very few protons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9np00007kDOI Listing

Ca-, Sr-, and Ba-Coordination polymers based on anthranilic acid via mechanochemistry.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, D-12489 Berlin, Germany.

Ca-, Sr-, and Ba-Based coordination polymers (CPs) were prepared mechanochemically by milling metal-hydroxide samples with anthranilic acid (oABAH). {[Ca(oABA)2(H2O)3]}n (1) consists of one-dimensional polymeric chains that are further connected by a hydrogen-bonding network. {[Sr(oABA)2(H2O)2]·H2O}n (2) is a one-dimensional CP in which water molecules bridge Sr2+ ions and increase the dimensionality by building an extended network. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9dt00991dDOI Listing

Computer simulations of the adsorption of an N-terminal peptide of statherin, SN15, and its mutants on hydroxyapatite surfaces.

Phys Chem Chem Phys 2019 Apr 17. Epub 2019 Apr 17.

Guangdong Provincial Key Lab for Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, People's Republic of China.

Statherin is a 43 amino acid long protein, which plays an important role in the process of biomineralization of enamel. In this work, we investigated the solvent effect on the adsorption of a peptide from the N-terminus of statherin, SN15, and its mutants SNA15 and SNS15 on the (001) face of hydroxyapatite [Ca10(PO4)6(OH)2, or HAP] with molecular dynamics simulations. The simulation results showed that the adsorption of the three peptides onto the HAP(001) surface was primarily driven by salt-bridge and electrostatic attraction in calcium phosphate (Ca/P) and sodium chloride (NaCl) solutions, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cp01638dDOI Listing

Multiple functional groups in UiO-66 improve chemical warfare agent simulant degradation.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92023-0358, USA.

A library of 26 mixed ligand UiO-66 analogs was synthesized, characterized, and screened for catalytic degradation of the chemical warfare agent (CWA) simulant dimethyl 4-nitrophenylphosphate (DMNP). The MOFs were screened and compared to physical mixtures of the same single component MOFs. Several of the MOFs display higher catalytic activity than the parent UiO-66 and other single ligand UiO-66 analogues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc02252jDOI Listing

Mapping aldehydic load in vivo by positron emission tomography with [F]NABF.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Dept. of Biology, University of Ottawa, Ottawa, Ontario, Canada. and Dept. of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada and University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

A new radiotracer, [18F]NA3BF3, capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [18F]NA3BF3 was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was then applied to mapping aldehydic load in a mouse model of sepsis. [18F]NA3BF3 may enable the direct investigation of the chemical biology of aldehydes in living subjects, and may open avenues for the adoption of endogenous aldehydic load as an imaging biomarker of inflammatory pathology. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C9CC01831J
Publisher Site
http://dx.doi.org/10.1039/c9cc01831jDOI Listing
April 2019
1 Read

Electrospray ionization photoelectron spectroscopy of cryogenic [EDTA·M(ii)] complexes (M = Ca, V-Zn): electronic structures and intrinsic redox properties.

Faraday Discuss 2019 Apr 17. Epub 2019 Apr 17.

Physical Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P. O. Box 999, MS K8-88, Richland, Washington 99352, USA.

We report here a systematic photoelectron spectroscopy (PES) and theoretical study of divalent transition metal (TM) EDTA complexes [EDTA·TM(ii)]2- (TM = V-Zn), along with the Ca(ii) species for comparison. Gaseous TM dianions (TM = Ca, Mn, Co, Ni, Cu and Zn) were successfully generated via electrospray ionization, and their PE spectra, with 157, 193, and 266 nm photons, were obtained at 20 K. The spectrum of each TM complex shows an extra peak at the lowest electron binding energy (eBE), compared to that of [EDTA·Ca(ii)]2-. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8fd00175hDOI Listing

Solar-driven carbon dioxide fixation using photosynthetic semiconductor bio-hybrids.

Faraday Discuss 2019 Apr 17. Epub 2019 Apr 17.

Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA. and Department of Chemistry, University of California, Berkeley, CA 94720, USA and Kavli Energy NanoSciences Institute at the University of California, Berkeley, CA 94720, USA.

Solar-driven conversion of carbon dioxide to value-added carbon products is an ambitious objective of ongoing research efforts. However, high overpotential, low selectivity and poor CO2 mass transfer plague purely inorganic electrocatalysts. In this instance, we can consider a class of biological organisms that have evolved to achieve CO2 fixation. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C8FD00187A
Publisher Site
http://dx.doi.org/10.1039/c8fd00187aDOI Listing
April 2019
1 Read

[In-hospital outcomes of transcutaneous coronary intervention and carotid endarterectomy in hybrid and staged regimens].

Angiol Sosud Khir 2019 ;25(1):101-107

Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.

The aim of this study was comparative assessment of in-hospital outcomes after hybrid and staged surgical management of patients presenting with haemodynamically significant lesions of the coronary (CA) and brachiocephalic arteries (BCA) treated by means of either endovascular or surgical techniques. Over the period from 2010 to 2017, we operated on a total of 197 patients with stenotic lesions of the carotid and coronary arteries. The strategy of revascularization included transcutaneous coronary intervention (TCI) and carotid endarterectomy (CEA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.33529/angio2019114DOI Listing
January 2019

The Curse of the All-Star Team: A Single-Season Prospective Shoulder MRI Study of Little League Baseball Players.

J Pediatr Orthop 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Orthopedics & Scoliosis Center.

Background: Throwing guidelines have been implemented in Little League baseball in an attempt to minimize injuries in young baseball players. We hypothesized that playing pitcher or catcher and increased innings played during the season would result in dominant shoulder magnetic resonance imaging (MRI) abnormalities.

Methods: A prospective evaluation of Little League players aged 10 to 12 years was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BPO.0000000000001391DOI Listing
  • Page 1 of 25936