Exp Biol Med (Maywood) 2021 May 26:15353702211015628. Epub 2021 May 26.
West African Centre for Cell Biology of Infectious Disease (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra 0000, Ghana.
produces a macrolide exotoxin, mycolactone which suppresses immune cells activity, is toxic to most cells and the key virulence factor in the pathogenesis of Buruli ulcer disease. Mycolactone is reported to mediate the production of reactive oxygen species in keratinocytes; cells that play critical role in wound healing. Increased levels of reactive oxygen species have been shown to disrupt the well-ordered process of wound repair; hence, the function of wound-healing cells such as macrophages, keratinocytes, and fibroblast could be impaired in the presence of the reactive oxygen species mediator, mycolactone. Read More