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    1 OF 19

    Molecular detection of Mycobacterium ulcerans in the environment and its relationship with Buruli ulcer occurrence in Zio and Yoto districts of maritime region in Togo.
    PLoS Negl Trop Dis 2018 May 21;12(5):e0006455. Epub 2018 May 21.
    Department for infectious diseases and tropical medicine (DITM), Medical center of the University of Munich (LMU), Munich, Germany.
    Background: Buruli Ulcer (BU) is a neglected tropical skin infection caused by Mycobacterium ulcerans. Residence near aquatic areas has been identified as an important source of transmission of M. ulcerans with increased risk of contracting Buruli ulcer. Read More

    Skin disease prevalence study in schoolchildren in rural Côte d'Ivoire: Implications for integration of neglected skin diseases (skin NTDs).
    PLoS Negl Trop Dis 2018 May 17;12(5):e0006489. Epub 2018 May 17.
    Global Buruli Ulcer Initiative, World Health Organization, Geneva, Switzerland.
    Background: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process.

    Methods: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa. Read More

    A protocol for culturing environmental strains of the Buruli ulcer agent, Mycobacterium ulcerans.
    Sci Rep 2018 Apr 30;8(1):6778. Epub 2018 Apr 30.
    Aix Marseille Université, URMITE, UMR CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Marseille, 13005, France.
    Contaminations and fastidiousness of M. ulcerans may have both hamper isolation of strains from environmental sources. We aimed to optimize decontamination and culture of environmental samples to circumvent both limitations. Read More

    Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer.
    PLoS Negl Trop Dis 2018 Apr 30;12(4):e0006429. Epub 2018 Apr 30.
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Paris, France.
    Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. Read More

    Does BCG Vaccination Protect Against Non-Tuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis.
    J Infect Dis 2018 Apr 7. Epub 2018 Apr 7.
    Department of Paediatrics, The University of Melbourne, Parkville, Australia.
    The incidence of non-tuberculous mycobacterial (NTM) infections is increasing worldwide, particularly NTM lymphadenitis and skin infections (Buruli ulcer). This review summarises the evidence for the protective effectiveness of Bacillus Calmette-Guérin (BCG) vaccination against NTM disease. A systematic search using PRISMA guidelines was done for controlled studies investigating the protective effectiveness of BCG vaccination against NTM disease in immunocompetent individuals. Read More

    Delayed versus standard assessment for excision surgery in patients with Buruli ulcer in Benin: a randomised controlled trial.
    Lancet Infect Dis 2018 Mar 28. Epub 2018 Mar 28.
    University of Groningen, Department of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, Groningen, Netherlands. Electronic address:
    Background: Surgical intervention was once the mainstay of treatment for Buruli ulcer disease, a neglected tropical disease caused by Mycobacterium ulcerans. Since the introduction of streptomycin and rifampicin for 8 weeks as standard care, surgery has persisted as an adjunct therapy, but its role is uncertain. We investigated the effect of delaying the decision to operate to 14 weeks on rates of healing without surgery. Read More

    Developing a Buruli ulcer community of practice in Bankim, Cameroon: A model for Buruli ulcer outreach in Africa.
    PLoS Negl Trop Dis 2018 Mar 27;12(3):e0006238. Epub 2018 Mar 27.
    School of Anthropology, University of Arizona, Tucson, United States of America.
    Background: In the Cameroon, previous efforts to identify Buruli ulcer (BU) through the mobilization of community health workers (CHWs) yielded poor results. In this paper, we describe the successful creation of a BU community of practice (BUCOP) in Bankim, Cameroon composed of hospital staff, former patients, CHWs, and traditional healers.

    Methods And Principle Findings: All seven stages of a well-defined formative research process were conducted during three phases of research carried out by a team of social scientists working closely with Bankim hospital staff. Read More

    The incubation period of Buruli ulcer (Mycobacterium ulcerans infection) in Victoria, Australia - Remains similar despite changing geographic distribution of disease.
    PLoS Negl Trop Dis 2018 Mar 19;12(3):e0006323. Epub 2018 Mar 19.
    Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
    Background: Buruli ulcer (BU) is a geographically-restricted infection caused by Mycobacterium ulcerans; contact with an endemic region is the primary risk factor for disease acquisition. Globally, efforts to estimate the incubation period of BU are often hindered as most patients reside permanently in endemic areas. However, in the south-eastern Australian state of Victoria, a significant proportion of people who acquire BU are visitors to endemic regions. Read More

    Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin.
    Case Rep Pathol 2018 10;2018:1351694. Epub 2018 Jan 10.
    Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerpen, Belgium.
    Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue. Read More

    Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.
    Cell Death Dis 2018 Mar 14;9(3):397. Epub 2018 Mar 14.
    Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
    Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational translocation of proteins into the endoplasmic reticulum (ER). An outstanding question is the molecular pathway linking this to its known cytotoxicity. Read More

    Diagnostic Accuracy of Clinical and Microbiological Signs in Patients with Skin Lesions Resembling Buruli Ulcer in an Endemic Region.
    Clin Infect Dis 2018 Mar 10. Epub 2018 Mar 10.
    Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes increasingly important. We therefore aimed to determine the diagnostic accuracy of clinical signs and microbiological tests in patients presenting with lesions clinically compatible with BU. Read More

    Implementation of a decentralized community-based treatment program to improve the management of Buruli ulcer in the Ouinhi district of Benin, West Africa.
    PLoS Negl Trop Dis 2018 Mar 12;12(3):e0006291. Epub 2018 Mar 12.
    School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.
    Background: Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In Benin, BU patient care is being integrated into the government health system. Read More

    Report of a series of 82 cases of Buruli ulcer from Nigeria treated in Benin, from 2006 to 2016.
    PLoS Negl Trop Dis 2018 Mar 9;12(3):e0006358. Epub 2018 Mar 9.
    Centre de Dépistage et de Traitement de l'Ulcère de Buruli d'Allada, Ministry of Health, Allada, Bénin.
    Background: Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin. Read More

    Mycobacterium tuberculosis complex genotypes circulating in Nigeria based on spoligotyping obtained from Ziehl-Neelsen stained slides extracted DNA.
    PLoS Negl Trop Dis 2018 Feb 15;12(2):e0006242. Epub 2018 Feb 15.
    Institut for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
    Methods: All State TB control programmes in Nigeria were requested to submit 25-50 smear-positive Ziehl-Neelsen (ZN) stained slides for screening during 2013-2014. DNA was extracted from 929 slides for spoligotyping and drug-resistance analysis using microbead-based flow-cytometry suspension arrays.

    Results: Spoligotyping results were obtained for 549 (59. Read More

    Comparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia.
    Appl Environ Microbiol 2018 Apr 2;84(8). Epub 2018 Apr 2.
    Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia
    Since 2000, cases of the neglected tropical disease Buruli ulcer, caused by infection with , have increased 100-fold around Melbourne (population 4.4 million), the capital of Victoria, in temperate southeastern Australia. The reasons for this increase are unclear. Read More

    Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region.
    PLoS Negl Trop Dis 2018 Feb 12;12(2):e0006233. Epub 2018 Feb 12.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.
    Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy lead to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More

    Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.
    PLoS Comput Biol 2018 Feb 5;14(2):e1005972. Epub 2018 Feb 5.
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, New Mexico, United States of America.
    Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction with at least two molecular targets and the inhibition of protein uptake into the endoplasmic reticulum. Although it has been shown that the toxin can passively permeate into host cells, it is clearly lipophilic. Read More

    Practice Guidelines for Clinical Microbiology Laboratories: Mycobacteria.
    Clin Microbiol Rev 2018 Apr 31;31(2). Epub 2018 Jan 31.
    Denver Health, Denver, Colorado, USA.
    Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. Read More

    [A Papua New Guinean with three foot ulcers].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2295
    Drs. A. Coenders, arts internationale gezondheidszorg en tropengeneeskunde in opleiding (thans niet verbonden aan een ziekenhuis).
    A 25-year-old Papuan presented with three painless foot ulcers with undermined edges, induration and oedema. The appearance was typical for Buruli ulcer, which is caused by Mycobacterium ulcerans. A smear was positive for acid fast bacilli. Read More

    Perceived causes and risk factors of Buruli ulcer among patients at Agogo Presbyterian hospital in Ashanti Region of Ghana.
    BMC Res Notes 2018 Jan 23;11(1):64. Epub 2018 Jan 23.
    Presbyterian Hospital, Agogo, Ashanti, Ghana.
    Objective: The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Read More

    Risk factors for Mycobacterium ulcerans infection (Buruli Ulcer) in Togo ─ a case-control study in Zio and Yoto districts of the maritime region.
    BMC Infect Dis 2018 01 19;18(1):48. Epub 2018 Jan 19.
    Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA), Laboratoire des Sciences Biologiques et des Substances Bioactives, Université de Lomé, Lomé, Togo.
    Background: Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation coverage. The objective of this study was to identify these risk factors in the districts of Zio and Yoto of the Maritime Region in Togo. Read More

    Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.
    J Clin Microbiol 2018 Apr 26;56(4). Epub 2018 Mar 26.
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Buruli ulcer is caused by This neglected disease occurs in scattered foci around the world, with a higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Read More

    The potent effect of mycolactone on lipid membranes.
    PLoS Pathog 2018 Jan 10;14(1):e1006814. Epub 2018 Jan 10.
    Univ. Lyon, Université Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS-UMR 5246, GEMBAS team, Lyon, France.
    Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated. Read More

    Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer.
    Chimia (Aarau) 2017 Dec;71(12):836-840
    Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France;, Email:
    Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases. Read More

    Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans.
    Clin Microbiol Rev 2018 Jan 13;31(1). Epub 2017 Dec 13.
    Aix-Marseille Université, URMITE, UMR CNRS 7278, IRD 198, INSERM 1095, Faculté de Médecine, Marseille, France
    Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, , derives from by genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor. -specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Read More

    Basidiobolomycosis Simulating a Infection in a Togolese Rural Child.
    Case Rep Dermatol Med 2017 17;2017:6905783. Epub 2017 Oct 17.
    Service de Dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo.
    Background: Basidiobolomycosis is a deep mycosis which preferentially affects rural young people in tropical countries. We report an atypical case, with multiple ulcers, simulating a Buruli ulcer.

    Case Report: A 5-year-old boy, living in a rural area, was seen for ulcers on the buttocks and at the back and right flank that had been in progress for 4 months. Read More

    Intra-amoebal killing of Mycobacterium ulcerans by Acanthamoeba griffini: A co-culture model.
    Microb Pathog 2018 Jan 20;114:1-7. Epub 2017 Nov 20.
    Aix Marseille Université, URMITE, UMR CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Marseille 13005, France. Electronic address:
    Mycobacterium ulcerans, a decaying Mycobacterium marinum derivative is responsible for Buruli ulcer, a notifiable non-contagious disabling infection highly prevalent in some West African countries. Aquatic environments are suspected to host M. ulcerans, however, the exact reservoirs remain unknown. Read More

    Mycobacterium ulcerans DNA in Bandicoot Excreta in Buruli Ulcer-Endemic Area, Northern Queensland, Australia.
    Emerg Infect Dis 2017 Dec;23(12):2042-2045
    To identify potential reservoirs/vectors of Mycobacterium ulcerans in northern Queensland, Australia, we analyzed environmental samples collected from the Daintree River catchment area, to which Buruli ulcer is endemic, and adjacent coastal lowlands by species-specific PCR. We detected M. ulcerans DNA in soil, mosquitoes, and excreta of bandicoots, which are small terrestrial marsupials. Read More

    Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.
    Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.
    Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
    Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

    Support needs of people living with Mycobacterium ulcerans (Buruli ulcer) disease in a Ghana rural community: a grounded theory study.
    Int J Dermatol 2017 Dec 23;56(12):1432-1437. Epub 2017 Oct 23.
    Professor in Public Health and Wellbeing, School of Health and Social Care, Bournemouth University, Bournemouth, UK.
    Introduction/background: Mycobacterium ulcerans (also known as Buruli ulcer) disease is a rare skin disease which is prevalent in rural communities in the tropics mostly in Africa. Mortality rate is low, yet morbidity and consequent disabilities affect the quality of life of sufferers.

    Aims: The aim of this paper is to use the grounded theory method to explore the support needs of people living with the consequences of Buruli ulcer in an endemic rural community in Ghana. Read More

    Susceptibility to Disease (Buruli ulcer) Is Associated with and Gene Polymorphisms.
    Front Microbiol 2017 4;8:1903. Epub 2017 Oct 4.
    Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
    Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, , produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Read More

    Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia.
    Emerg Infect Dis 2018 Jan 17;24(1). Epub 2018 Jan 17.
    Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998-May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. Read More

    Assessment of health care workers' knowledge, attitude and risk perception of Buruli ulcer disease in Southern Nigeria.
    Trans R Soc Trop Med Hyg 2017 May;111(5):226-232
    Department of Medicine, Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria.
    Background: Poor knowledge of health care workers may be responsible for the under-diagnosis and low notification of Buruli ulcer (BU) in high-burden settings. This study assessed health care workers' knowledge, attitude and risk perception of BU in Southern Nigeria.

    Methods: We conducted a cross-sectional survey among 186 health care workers recruited from 58 health facilities in four states of Southern Nigeria. Read More

    Evidences of the Low Implication of Mosquitoes in the Transmission of , the Causative Agent of Buruli Ulcer.
    Can J Infect Dis Med Microbiol 2017 28;2017:1324310. Epub 2017 Aug 28.
    Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box 581, Legon, Accra, Ghana.
    Background: Buruli ulcer (BU) continues to be a serious public health threat in wet tropical regions and the mode of transmission of its etiological agent, (), remains poorly understood. In this study, mosquito species collected in endemic villages in Benin were screened for the presence of . In addition, the ability of mosquitoes larvae to pick up from their environment and remain colonized through the larval developmental stages to the adult stage was investigated. Read More

    The chemistry and biology of mycolactones.
    Beilstein J Org Chem 2017 11;13:1596-1660. Epub 2017 Aug 11.
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
    Mycolactones are a group of macrolides excreted by the human pathogen , which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of , mycolactones are central to the pathogenesis of the neglected disease Buruli ulcer, a chronic and debilitating medical condition characterized by necrotic skin ulcers. Due to their complex structure and fascinating biology, mycolactones have inspired various total synthesis endeavors and structure-activity relationship studies. Read More

    Mapping biopsy for Buruli ulcer self-medicated with occlusive dressing.
    J Dermatol 2018 Jan 11;45(1):72-75. Epub 2017 Sep 11.
    Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.
    Buruli ulcer is the third most common mycobacterial infection next to tuberculosis and leprosy caused by Mycobacterium ulcerans. Although it affects the skin, subcutaneous tissues, muscles and sometimes bones, there is no reliable evidence to determine the extent of debridement. We present here a case of Buruli ulcer treated successfully with a preoperative mapping biopsy procedure, which had been self-medicated with occlusive dressing. Read More

    [Nursing perspective on the care of people with leprosy in Ivory Coast].
    Rev Infirm 2017 Aug - Sep;66(233):31-34
    École de santé publique de l'Université libre de Bruxelles Campus Erasme, Route de Lennik, 808 1070 Bruxelles, Belgique; Haute École Libre de Bruxelles Ilya Prigogine Campus Erasme, Route de Lennik, 808 1070 Bruxelles, Belgique; Centre de recherche économie de la santé-Gestion des institutions de soins-Sciences infirmières, CR1 Campus Erasme CP 592, Route de Lennik, 808 1070 Bruxelles, Belgique. Electronic address:
    Lucien Gbadié is a nurse at the Raoul-Follereau Institute in Adzopé, Ivory Coast. In this article, he describes how people with leprosy or Buruli ulcer are treated and supported. Read More

    The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission.
    PLoS Negl Trop Dis 2017 Aug 18;11(8):e0005800. Epub 2017 Aug 18.
    University of Melbourne, Department of Medicine, Austin Health, Victoria, Australia.
    Background: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body.

    Methods: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. Read More

    Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
    PLoS Negl Trop Dis 2017 Aug 4;11(8):e0005834. Epub 2017 Aug 4.
    Department of Pathology, Kagoshima University, Kagoshima, Japan.
    Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. Read More

    Bacterial diversity in Buruli ulcer skin lesions: Challenges in the clinical microbiome analysis of a skin disease.
    PLoS One 2017 27;12(7):e0181994. Epub 2017 Jul 27.
    Mycobacteriology unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: Buruli ulcer (BU) is an infectious disease caused by Mycobacterium ulcerans and considered the third most prevalent mycobacterial disease in humans. Secondary bacterial infections in open BU lesions are the main cause of pain, delayed healing and systemic illness, resulting in prolonged hospital stay. Thus, understanding the diversity of bacteria, termed the microbiome, in these open lesions is important for proper treatment. Read More

    In Silico Prediction of Antibiotic Resistance in Agy99 through Whole Genome Sequence Analysis.
    Am J Trop Med Hyg 2017 Sep 27;97(3):810-814. Epub 2017 Jul 27.
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 7278-IRD 198 IHU, Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, Marseille, France.
    Buruli ulcer is an emerging infectious disease caused by that has been reported from 33 countries. Antimicrobial agents either alone or in combination with surgery have been proved to be clinically relevant and therapeutic strategies have been deduced mainly from the empirical experience. The genome sequences of . Read More

    Hearing thresholds in patients with drug-resistant tuberculosis: baseline audiogram configurations and associations.
    J Bras Pneumol 2017 May-Jun;43(3):195-201
    . Ogun State Tuberculosis, Leprosy and Buruli Ulcer Control Program, Ministry of Health, Ogun State, Nigeria.
    Objective:: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations.

    Methods:: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation). Read More

    Ecohealth research in Africa: Where from-Where to?
    Acta Trop 2017 Nov 18;175:1-8. Epub 2017 Jul 18.
    Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland.
    Epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. This is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change and how these changes affect the health and wellbeing of humans, animals and ecosystems and the services they provide. This paper is an overview of a special issue of Acta Tropica, whose 15 publications reflect a geographically and epidemiologically diverse landscape of ecohealth. Read More

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