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    1 OF 18

    Mycobacterium tuberculosis complex genotypes circulating in Nigeria based on spoligotyping obtained from Ziehl-Neelsen stained slides extracted DNA.
    PLoS Negl Trop Dis 2018 Feb 15;12(2):e0006242. Epub 2018 Feb 15.
    Institut for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
    Methods: All State TB control programmes in Nigeria were requested to submit 25-50 smear-positive Ziehl-Neelsen (ZN) stained slides for screening during 2013-2014. DNA was extracted from 929 slides for spoligotyping and drug-resistance analysis using microbead-based flow-cytometry suspension arrays.

    Results: Spoligotyping results were obtained for 549 (59. Read More

    Comparative genomics showsmigration and expansion has preceded the rise of Buruli ulcer in south-eastern Australia.
    Appl Environ Microbiol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia
    Since 2012, cases of the neglected tropical disease Buruli ulcer, caused by infection withhave increased 100-fold since 2000 around Melbourne, (population 4.4 million) the capital of Victoria in temperate south-eastern Australia. The reasons for this increase are unclear. Read More

    Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region.
    PLoS Negl Trop Dis 2018 Feb 12;12(2):e0006233. Epub 2018 Feb 12.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.
    Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy lead to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More

    Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.
    PLoS Comput Biol 2018 Feb 5;14(2):e1005972. Epub 2018 Feb 5.
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, New Mexico, United States of America.
    Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction with at least two molecular targets and the inhibition of protein uptake into the endoplasmic reticulum. Although it has been shown that the toxin can passively permeate into host cells, it is clearly lipophilic. Read More

    Practice Guidelines for Clinical Microbiology Laboratories: Mycobacteria.
    Clin Microbiol Rev 2018 Apr 31;31(2). Epub 2018 Jan 31.
    Denver Health, Denver, Colorado, USA.
    Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. Read More

    [A Papua New Guinean with three foot ulcers].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2295
    Drs. A. Coenders, arts internationale gezondheidszorg en tropengeneeskunde in opleiding (thans niet verbonden aan een ziekenhuis).
    A 25-year-old Papuan presented with three painless foot ulcers with undermined edges, induration and oedema. The appearance was typical for Buruli ulcer, which is caused by Mycobacterium ulcerans. A smear was positive for acid fast bacilli. Read More

    Perceived causes and risk factors of Buruli ulcer among patients at Agogo Presbyterian hospital in Ashanti Region of Ghana.
    BMC Res Notes 2018 Jan 23;11(1):64. Epub 2018 Jan 23.
    Presbyterian Hospital, Agogo, Ashanti, Ghana.
    Objective: The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Read More

    Risk factors for Mycobacterium ulcerans infection (Buruli Ulcer) in Togo ─ a case-control study in Zio and Yoto districts of the maritime region.
    BMC Infect Dis 2018 01 19;18(1):48. Epub 2018 Jan 19.
    Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA), Laboratoire des Sciences Biologiques et des Substances Bioactives, Université de Lomé, Lomé, Togo.
    Background: Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation coverage. The objective of this study was to identify these risk factors in the districts of Zio and Yoto of the Maritime Region in Togo. Read More

    Buruli ulcer. Review of a neglected skin mycobacterial disease.
    J Clin Microbiol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA
    Buruli ulcer is caused byThis neglected disease occurs in scattered foci around the world with higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Read More

    The potent effect of mycolactone on lipid membranes.
    PLoS Pathog 2018 Jan 10;14(1):e1006814. Epub 2018 Jan 10.
    Univ. Lyon, Université Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS-UMR 5246, GEMBAS team, Lyon, France.
    Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated. Read More

    Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer.
    Chimia (Aarau) 2017 Dec;71(12):836-840
    Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France;, Email:
    Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases. Read More

    Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans.
    Clin Microbiol Rev 2018 Jan 13;31(1). Epub 2017 Dec 13.
    Aix-Marseille Université, URMITE, UMR CNRS 7278, IRD 198, INSERM 1095, Faculté de Médecine, Marseille, France
    Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent,, derives fromby genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor.-specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Read More

    Basidiobolomycosis Simulating aInfection in a Togolese Rural Child.
    Case Rep Dermatol Med 2017 17;2017:6905783. Epub 2017 Oct 17.
    Service de Dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo.
    Background: Basidiobolomycosis is a deep mycosis which preferentially affects rural young people in tropical countries. We report an atypical case, with multiple ulcers, simulating a Buruli ulcer.

    Case Report: A 5-year-old boy, living in a rural area, was seen for ulcers on the buttocks and at the back and right flank that had been in progress for 4 months. Read More

    Intra-amoebal killing of Mycobacterium ulcerans by Acanthamoeba griffini: A co-culture model.
    Microb Pathog 2018 Jan 20;114:1-7. Epub 2017 Nov 20.
    Aix Marseille Université, URMITE, UMR CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Marseille 13005, France. Electronic address:
    Mycobacterium ulcerans, a decaying Mycobacterium marinum derivative is responsible for Buruli ulcer, a notifiable non-contagious disabling infection highly prevalent in some West African countries. Aquatic environments are suspected to host M. ulcerans, however, the exact reservoirs remain unknown. Read More

    Mycobacterium ulcerans DNA in Bandicoot Excreta in Buruli Ulcer-Endemic Area, Northern Queensland, Australia.
    Emerg Infect Dis 2017 Dec;23(12):2042-2045
    To identify potential reservoirs/vectors of Mycobacterium ulcerans in northern Queensland, Australia, we analyzed environmental samples collected from the Daintree River catchment area, to which Buruli ulcer is endemic, and adjacent coastal lowlands by species-specific PCR. We detected M. ulcerans DNA in soil, mosquitoes, and excreta of bandicoots, which are small terrestrial marsupials. Read More

    Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.
    Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.
    Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
    Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

    Support needs of people living with Mycobacterium ulcerans (Buruli ulcer) disease in a Ghana rural community: a grounded theory study.
    Int J Dermatol 2017 Dec 23;56(12):1432-1437. Epub 2017 Oct 23.
    Professor in Public Health and Wellbeing, School of Health and Social Care, Bournemouth University, Bournemouth, UK.
    Introduction/background: Mycobacterium ulcerans (also known as Buruli ulcer) disease is a rare skin disease which is prevalent in rural communities in the tropics mostly in Africa. Mortality rate is low, yet morbidity and consequent disabilities affect the quality of life of sufferers.

    Aims: The aim of this paper is to use the grounded theory method to explore the support needs of people living with the consequences of Buruli ulcer in an endemic rural community in Ghana. Read More

    Susceptibility toDisease (Buruli ulcer) Is Associated withandGene Polymorphisms.
    Front Microbiol 2017 4;8:1903. Epub 2017 Oct 4.
    Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
    Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent,, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed todevelop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Read More

    Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia.
    Emerg Infect Dis 2018 Jan 17;24(1). Epub 2018 Jan 17.
    Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998-May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. Read More

    Assessment of health care workers' knowledge, attitude and risk perception of Buruli ulcer disease in Southern Nigeria.
    Trans R Soc Trop Med Hyg 2017 May;111(5):226-232
    Department of Medicine, Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria.
    Background: Poor knowledge of health care workers may be responsible for the under-diagnosis and low notification of Buruli ulcer (BU) in high-burden settings. This study assessed health care workers' knowledge, attitude and risk perception of BU in Southern Nigeria.

    Methods: We conducted a cross-sectional survey among 186 health care workers recruited from 58 health facilities in four states of Southern Nigeria. Read More

    Evidences of the Low Implication of Mosquitoes in the Transmission of, the Causative Agent of Buruli Ulcer.
    Can J Infect Dis Med Microbiol 2017 28;2017:1324310. Epub 2017 Aug 28.
    Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box 581, Legon, Accra, Ghana.
    Background: Buruli ulcer (BU) continues to be a serious public health threat in wet tropical regions and the mode of transmission of its etiological agent,(), remains poorly understood. In this study, mosquito species collected in endemic villages in Benin were screened for the presence of. In addition, the ability of mosquitoes larvae to pick upfrom their environment and remain colonized through the larval developmental stages to the adult stage was investigated. Read More

    The chemistry and biology of mycolactones.
    Beilstein J Org Chem 2017 11;13:1596-1660. Epub 2017 Aug 11.
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
    Mycolactones are a group of macrolides excreted by the human pathogen, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of, mycolactones are central to the pathogenesis of the neglected disease Buruli ulcer, a chronic and debilitating medical condition characterized by necrotic skin ulcers. Due to their complex structure and fascinating biology, mycolactones have inspired various total synthesis endeavors and structure-activity relationship studies. Read More

    Mapping biopsy for Buruli ulcer self-medicated with occlusive dressing.
    J Dermatol 2018 Jan 11;45(1):72-75. Epub 2017 Sep 11.
    Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.
    Buruli ulcer is the third most common mycobacterial infection next to tuberculosis and leprosy caused by Mycobacterium ulcerans. Although it affects the skin, subcutaneous tissues, muscles and sometimes bones, there is no reliable evidence to determine the extent of debridement. We present here a case of Buruli ulcer treated successfully with a preoperative mapping biopsy procedure, which had been self-medicated with occlusive dressing. Read More

    [Nursing perspective on the care of people with leprosy in Ivory Coast].
    Rev Infirm 2017 Aug - Sep;66(233):31-34
    École de santé publique de l'Université libre de Bruxelles Campus Erasme, Route de Lennik, 808 1070 Bruxelles, Belgique; Haute École Libre de Bruxelles Ilya Prigogine Campus Erasme, Route de Lennik, 808 1070 Bruxelles, Belgique; Centre de recherche économie de la santé-Gestion des institutions de soins-Sciences infirmières, CR1 Campus Erasme CP 592, Route de Lennik, 808 1070 Bruxelles, Belgique. Electronic address:
    Lucien Gbadié is a nurse at the Raoul-Follereau Institute in Adzopé, Ivory Coast. In this article, he describes how people with leprosy or Buruli ulcer are treated and supported. Read More

    The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission.
    PLoS Negl Trop Dis 2017 Aug 18;11(8):e0005800. Epub 2017 Aug 18.
    University of Melbourne, Department of Medicine, Austin Health, Victoria, Australia.
    Background: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body.

    Methods: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. Read More

    Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
    PLoS Negl Trop Dis 2017 Aug 4;11(8):e0005834. Epub 2017 Aug 4.
    Department of Pathology, Kagoshima University, Kagoshima, Japan.
    Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. Read More

    Bacterial diversity in Buruli ulcer skin lesions: Challenges in the clinical microbiome analysis of a skin disease.
    PLoS One 2017 27;12(7):e0181994. Epub 2017 Jul 27.
    Mycobacteriology unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: Buruli ulcer (BU) is an infectious disease caused by Mycobacterium ulcerans and considered the third most prevalent mycobacterial disease in humans. Secondary bacterial infections in open BU lesions are the main cause of pain, delayed healing and systemic illness, resulting in prolonged hospital stay. Thus, understanding the diversity of bacteria, termed the microbiome, in these open lesions is important for proper treatment. Read More

    In Silico Prediction of Antibiotic Resistance inAgy99 through Whole Genome Sequence Analysis.
    Am J Trop Med Hyg 2017 Sep 27;97(3):810-814. Epub 2017 Jul 27.
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 7278-IRD 198 IHU, Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, Marseille, France.
    Buruli ulcer is an emerging infectious disease caused bythat has been reported from 33 countries. Antimicrobial agents either alone or in combination with surgery have been proved to be clinically relevant and therapeutic strategies have been deduced mainly from the empirical experience. The genome sequences of. Read More

    Hearing thresholds in patients with drug-resistant tuberculosis: baseline audiogram configurations and associations.
    J Bras Pneumol 2017 May-Jun;43(3):195-201
    . Ogun State Tuberculosis, Leprosy and Buruli Ulcer Control Program, Ministry of Health, Ogun State, Nigeria.
    Objective:: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations.

    Methods:: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation). Read More

    Ecohealth research in Africa: Where from-Where to?
    Acta Trop 2017 Nov 18;175:1-8. Epub 2017 Jul 18.
    Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland.
    Epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. This is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change and how these changes affect the health and wellbeing of humans, animals and ecosystems and the services they provide. This paper is an overview of a special issue of Acta Tropica, whose 15 publications reflect a geographically and epidemiologically diverse landscape of ecohealth. Read More

    A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.
    Toxins (Basel) 2017 Jul 18;9(7). Epub 2017 Jul 18.
    Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France.
    Mycolactone, a polyketide molecule produced by, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. Read More

    Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005695. Epub 2017 Jul 3.
    Kwame Nkrumah University of Science and Technology (KNUST), School of Medical Sciences and Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
    Introduction: Buruli ulcer (BU) caused by Mycobacterium ulcerans is effectively treated with rifampicin and streptomycin for 8 weeks but some lesions take several months to heal. We have shown previously that some slowly healing lesions contain mycolactone suggesting continuing infection after antibiotic therapy. Now we have determined how rapidly combined M. Read More

    Environmental and Behavioral Drivers of Buruli Ulcer Disease in Selected Communities Along the Densu River Basin of Ghana: A Case-Control Study.
    Am J Trop Med Hyg 2017 May;96(5):1076-1083
    Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
    AbstractThe exact route of transmission of(MU) (causative agent of Buruli ulcer [BU]), risk factors, and reservoir hosts are not clearly known, although it has been identified as an environmental pathogen. This study assessed potential environmental and behavioral risk factors that influence BU infections. We conducted a case-control study where cases were matched by their demographic characteristics and place of residence. Read More

    Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities.
    PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.
    School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.
    Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More

    Draft Genome Sequence ofS4018 Isolated from a Patient with an Active Buruli Ulcer in Benin, Africa.
    Genome Announc 2017 Apr 27;5(17). Epub 2017 Apr 27.
    CRCINA, Inserm, CNRS, Université d'Angers, Université de Nantes, Nantes, France
    Currently, there are only two publicly available genomes of-the causative agent of the neglected, but devastating, tropical disease Buruli ulcer. Here, we report the draft genome sequence of isolate S4018, recovered from an active cutaneous lesion of a patient with Buruli ulcer in Benin, Africa. Read More

    Global and local environmental changes as drivers of Buruli ulcer emergence.
    Emerg Microbes Infect 2017 Apr 26;6(4):e22. Epub 2017 Apr 26.
    Institut de Recherche pour le Développement, Département Ecologie, Biodiversité et Fonctionnement des Ecosystemes Continentaux, UMR BOREA IRD 207, CNRS 7208, MNHN, UPMC, Muséum National d'Histoire Naturelle, 75231 Paris, France.
    Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Read More

    Virulence potential of Staphylococcus aureus isolates from Buruli ulcer patients.
    Int J Med Microbiol 2017 Jun 19;307(4-5):223-232. Epub 2017 Apr 19.
    Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Buruli ulcer (BU) is a necrotizing infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU wounds may also be colonized with other microorganisms including Staphylococcus aureus. This study aimed to characterize the virulence factors of S. Read More

    Disease ecology, health and the environment: a framework to account for ecological and socio-economic drivers in the control of neglected tropical diseases.
    Philos Trans R Soc Lond B Biol Sci 2017 Jun;372(1722)
    Department of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA.
    Reducing the burden of neglected tropical diseases (NTDs) is one of the key strategic targets advanced by the Sustainable Development Goals. Despite the unprecedented effort deployed for NTD elimination in the past decade, their control, mainly through drug administration, remains particularly challenging: persistent poverty and repeated exposure to pathogens embedded in the environment limit the efficacy of strategies focused exclusively on human treatment or medical care. Here, we present a simple modelling framework to illustrate the relative role of ecological and socio-economic drivers of environmentally transmitted parasites and pathogens. Read More

    Landscape and environmental influences on Mycobacterium ulcerans distribution among aquatic sites in Ghana.
    PLoS One 2017 24;12(4):e0176375. Epub 2017 Apr 24.
    Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
    Buruli ulcer, caused by Mycobacterium ulcerans, is highly endemic in West Africa. While the mode of transmission is unknown, many studies associate Buruli ulcer with different types of water exposure. We present results from the largest study to date to test for M. Read More

    Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia.
    Emerg Infect Dis 2017 05;23(5):837-840
    We conducted epidemiologic and genetic analyses of family clusters of Mycobacterium ulcerans (Buruli ulcer) disease in southeastern Australia. We found that the incidence of M. ulcerans disease in family members was increased. Read More

    Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer.
    PLoS Negl Trop Dis 2017 Apr 14;11(4):e0005553. Epub 2017 Apr 14.
    Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
    Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring the causative agent, Mycobacterium ulcerans, and BU. Here we tested a contaminated skin model of BU transmission by dipping the tails from healthy mice in cultures of the causative agent, Mycobacterium ulcerans. Read More

    In Vitro Susceptibility ofIsolates to Selected Antimicrobials.
    Can J Infect Dis Med Microbiol 2017 14;2017:5180984. Epub 2017 Mar 14.
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
    The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one. This is as a result of drug misuse by health personnel and patients' noncompliance to treatment regimen. Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease. Read More

    An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by.
    Front Microbiol 2017 24;8:512. Epub 2017 Mar 24.
    Center for Research in Cancerology and Immunology Nantes-Angers, Institut National de la Santé et de la Recherche Médicale, Université de Nantes, Université d'AngersAngers, France; Equipe Atip-Avenir, Center for Research in Cancerology and Immunology Nantes-Angers, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire et Université d'AngersAngers, France.
    Bacterial transcriptome analyses during host colonization are essential to decipher the complexity of the relationship between the bacterium and its host. RNA sequencing (RNA-seq) is a promising approach providing valuable information about bacterial adaptation, the host response and, in some cases, mutual tolerance underlying crosstalk, as recently observed in the context ofinfection. Buruli ulcer is caused by. Read More

    Chronic cutaneous mycobacterial ulcers due to Mycobacterium ulcerans (Buruli ulcer): the first indigenous case report from Jordan and a literature review.
    Int J Infect Dis 2017 May 23;58:77-81. Epub 2017 Mar 23.
    Internal Medicine Department, Jordan Hospital and Medical Center, Amman, Jordan.
    Background: Buruli ulcer is the third most common mycobacterial infection worldwide. It is endemic in tropical, subtropical, and temperate climates. It causes devastating disease with morbidity and mortality. Read More

    [Nontuberculous mycobacteria].
    Hautarzt 2017 May;68(5):403-411
    Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
    Dermatologically relevant nontuberculous mycobacteria (NTM) include Mycobacterium marinum and Mycobacterium ulcerans and different rapidly growing mycobacteria (RGM). RGM are widely present in the environment and are facultative pathogenic. Diagnostic detection of nontuberculous mycobacteria is frequently challenging. Read More

    Experimental demonstration of the possible role of Acanthamoeba polyphaga in the infection and disease progression in Buruli Ulcer (BU) using ICR mice.
    PLoS One 2017 22;12(3):e0172843. Epub 2017 Mar 22.
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
    The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining. Read More

    Ecology and Feeding Habits Drive Infection of Water Bugs with Mycobacterium ulcerans.
    Ecohealth 2017 06 17;14(2):329-341. Epub 2017 Mar 17.
    UMR MIVEGEC IRD, CNRS, Université de Montpellier, Centre IRD de Montpellier, BP 64501, 34394, Montpellier Cedex, France.
    Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer, is present in a wide spectrum of environments, including terrestrial and aquatic ecosystems in tropical regions. The most promising studies on the epidemiological risk of this disease suggest that some ecological settings may favor infection of animals with MU including human. A species' needs and impacts on resources and the environment, i. Read More

    The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.
    ACS Chem Biol 2017 05 27;12(5):1297-1307. Epub 2017 Mar 27.
    Swiss Tropical and Public Health Institute , Socinstrasse 57, 4002 Basel, Switzerland.
    Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, is central to the pathogenesis of the chronic necrotizing skin disease Buruli ulcer (BU). Here we show that mycolactone acts as an inhibitor of the mechanistic Target of Rapamycin (mTOR) signaling pathway by interfering with the assembly of the two distinct mTOR protein complexes mTORC1 and mTORC2, which regulate different cellular processes. Inhibition of the assembly of the rictor containing mTORC2 complex by mycolactone prevents phosphorylation of the serine/threonine protein kinase Akt. Read More

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