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    Characterization of variables for potential impact on vancomycin pharmacokinetics in thermal or inhalation injury.
    Burns 2017 Oct 30. Epub 2017 Oct 30.
    Medical Director, Department of Plastic Surgery, Firefighters Regional Burn Center, Regional One Health, 877 Jefferson Avenue, Memphis, TN 38103, USA; Professor, Department of Plastic Surgery, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA. Electronic address:
    Objective: To characterize the pharmacokinetics of vancomycin dosing in thermal or inhalation injury as they relate to percent total body surface area burn (TBSA) and days since injury (DSI).

    Methods: This retrospective 3-year study included patients with thermal or inhalation injury receiving vancomycin. Patient demographics and course data were collected using the institution's electronic medical record. Read More

    Rediscovery of an old article reporting that the area around the epicenter in Hiroshima was heavily contaminated with residual radiation, indicating that exposure doses of A-bomb survivors were largely underestimated.
    J Radiat Res 2017 Sep;58(5):745-754
    School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Naka Ward, Okayama City 703-8234, Japan.
    The A-bomb blast released a huge amount of energy: thermal radiation (35%), blast energy (50%), and nuclear radiation (15%). Of the 15%, 5% was initial radiation released within 30 s and 10% was residual radiation, the majority of which was fallout. Exposure doses of hibakusha (A-bomb survivors) were estimated solely on the basis of the initial radiation. Read More

    Assessment of novel tobacco heating product THP1.0. Part 3: Comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions.
    Regul Toxicol Pharmacol 2017 Oct 25. Epub 2017 Oct 25.
    Research and Development, British American Tobacco Investments Ltd, Regents Park Road, Southampton, Hampshire SO15 8TL, UK.
    For a tobacco heating product (THP), which heats rather than burns tobacco, the emissions of toxicants in the aerosol were compared with those in cigarette smoke under a machine-puffing regimen of puff volume 55 ml, puff duration 2 s and puff interval 30 s. The list of toxicants included those proposed by Health Canada, the World Health Organization Study Group on Tobacco Product Regulation (TobReg), the US Food and Drug Administration and possible thermal breakdown products. In comparison to the University of Kentucky 3R4F reference cigarette the toxicant levels in the THP1. Read More

    Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms.
    Burns 2017 Oct 19. Epub 2017 Oct 19.
    Department of Plastic Reconstructive Surgery, Burn Center, Hôpital Saint Louis, AP-HP 1 Avenue Claude Vellefaux, 75010 Paris, France.
    Introduction With more than 10 million of daily users, e-cigarettes encountered a great success. But in the past few years, the number of medical reports of injuries caused by the explosion of e-cigarettes has significantly increased. This article aims at reporting our series and reviewing the literature to propose a new classification based on the mechanisms of injuries related to e-cigarettes that can guide non-specialists and specialists in the management of these patients. Read More

    Comparison of non-surgical methods for the treatment of deep partial thickness skin burns of the hand.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Department of Thermal Injuries, Republican Vilnius University Hospital, Lithuania.
    This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. Read More

    Prospective comparative evaluation study of Laser Doppler Imaging and thermal imaging in the assessment of burn depth.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Scar Free Foundation Centre for Burns Research, University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK; University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address:
    Introduction: The accurate assessment of burn depth is challenging but crucial for surgical excision and tissue preservation. Laser Doppler Imaging (LDI) has gained increasing acceptance as a tool to aid depth assessment but its adoption is hampered by high costs, long scan times and limited portability. Thermal imaging is touted as a suitable alternative however few comparison studies have been done. Read More

    The effect of adipose derived stromal vascular fraction on stasis zone in an experimental burn model.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Baskent University Faculty of Medicine, Department of General Surgery, Ankara, Turkey.
    Background: Stasis zone is the surrounding area of the coagulation zone which is an important part determining the extent of the necrosis in burn patients. In our study we aim to salvage the stasis zone by injecting adipose derived stromal vascular fraction (ADSVF).

    Methods: Thermal injury was applied on dorsum of Sprague-Dawley rats (n=20) by the "comb burn" model as described previously. Read More

    Safety and efficacy of uninterrupted perioperative enteral feeding in pediatric burn patients.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Burn Program, Division of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University, United States.
    Introduction: Burn injuries are a significant cause of morbidity. Early enteral nutrition has been shown to improve outcomes, however enteral nutrition is often held for procedures receiving general anesthesia. Limited data is available on uninterrupted perioperative nutrition in pediatric burn patients. Read More

    The application of mesenchymal stem cells to treat thermal and radiation burns.
    Adv Drug Deliv Rev 2017 Oct 12. Epub 2017 Oct 12.
    Beckman Research Centre, Department of Experimental Therapeutics, City of Hope, Duarte, CA 91010, United States. Electronic address:
    Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns. Read More

    Burn injury: review of pathophysiology and therapeutic modalities in major burns.
    Ann Burns Fire Disasters 2017 Jun;30(2):95-102
    Division of Plastic & Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
    Despite a considerable decrease in their incidence worldwide, burn injuries remain one of the commonest forms of trauma and account for a weighty proportion of trauma cases in health-care emergencies around the globe. Although the latest data reveal a substantial decline in burn-related mortality and hospital admissions in the US over the past three decades, severe thermal injuries continue to trigger devastating morbidity and significant mortality while their management remains a dynamic challenge for the entire medical and paramedical community. Concrete evidence continues to be established regarding burn-associated pathophysiologic responses, and their destructive sequelae and deleterious effects in survivors at cellular, systemic as well as socio-economic level. Read More

    Epidemiology and outcome of 2,590 burned patients in Northwest Iran.
    Ann Burns Fire Disasters 2017 Jun;30(2):85-90
    Department of Surgery, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
    Burns are calamities with considerable morbidity and mortality rates. We attempted to examine the epidemiology of burns in Zanjan city, in northwest Iran, by a systematic study of existing information. The medical files of 2,590 thermal burn patients treated in our hospital in Zanjan city, Iran, from December 2010 to November 2016 were studied. Read More

    Elevated aqueous cytokine levels in eyes with ocular surface diseases.
    Am J Ophthalmol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.
    Purpose: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases.

    Design: Prospective consecutive case series.

    Methods: This study includes 14 patients (62. Read More

    Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft.
    Graefes Arch Clin Exp Ophthalmol 2017 Oct 2. Epub 2017 Oct 2.
    Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
    Purpose: The goal of this project was to demonstrate the feasibility of coupling the indirect ophthalmoscope laser delivery system with the 690 nm wavelength diode laser used to perform photodynamic therapy (PDT) in the treatment of retinoblastoma.

    Methods: For phase 1, a total of six pigmented rabbits were treated with the indirect laser delivery system. The laser source was provided by the Lumenis Opal 690 nm laser unit, delivered through a 810 nm Indirect ophthalmoscope headpiece and a hand-held 28-diopter indirect lens (1. Read More

    Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury.
    Clin Toxicol (Phila) 2017 Oct 3:1-3. Epub 2017 Oct 3.
    a U.S. Army Institute of Surgical Research , Fort Sam Houston , TX , USA.
    Context: Hydroxocobalamin is an effective cyanide antidote. While erythema, hypertension, and chromaturia are recognized side effects, methemoglobinemia has not been reported. Methemoglobin levels are most accurately measured by co-oximetry. Read More

    Thermal stability of mafenide and amphotericin B topical solution.
    Burns 2017 Sep 18. Epub 2017 Sep 18.
    United States Army Institute of Surgical Research, Fort Sam, Houston, TX 78234, United States; Uniformed Services University of Health Sciences, Bethesda, MD 20814, United States.
    Objective: Fungal infections remain a major cause of mortality in the burned population. Mafenide acetate/amphotericin B solution (SMAT) has been used topically for prophylaxis and treatment of these infections. Current manufacturer guidelines only guarantee the stability of mafenide solution and amphotericin B at room temperature. Read More

    [Systematic evaluation on effectiveness and safety of recombinant human growth hormone in treating adult patients with severe burn].
    Zhonghua Shao Shang Za Zhi 2017 Sep;33(9):568-573
    West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
    Objective: To systcmatically evaluate the effectiveness and safety of recombinant human growth hormone (rhGH) in treating adults with severe burn. Methods: Databases including PubMed, Cochrane Library, and Embase were searched using key words " burns, thermal, human growth hormone, growth hormone, hGH, and somatropin (human)" , and China Biology Medicine disc, Chinese Journals Full-text Database, VIP Database, and Wanfang Database were searched using key words in Chinese version "," to obtain the randomized controlled trials about rhGH in the treatment of adults with severe burn from the establishment of each database to December 2016. The measurement indexes included hemoglobin (Hb) and plasma total protein, inflammatory factors [including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)], incidence rate of sepsis, incidence rate of hyperglycemia, wound healing time, length of stay, and mortality rate. Read More

    Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases.
    Case Rep Ophthalmol 2017 May-Aug;8(2):429-435. Epub 2017 Aug 8.
    Department of Ophthalmology, KKU Eye Center, Khon Kaen University, Khon Kaen, Thailand.
    Background: We report 3 patients with laser-induced choroidal neovascularization (CNV).

    Method: Retrospective, observational case series. Medical charts and photographs were reviewed. Read More

    Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach.
    Int J Mol Sci 2017 Sep 15;18(9). Epub 2017 Sep 15.
    Department of Medicine, Division of Hematology Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.
    Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein folding and maturation of a variety of "client" proteins protecting them from degradation, oxidative stress, hypoxia, and thermal stress. Hence, they are significant regulators of cellular proliferation, differentiation and strongly implicated in the molecular orchestration of cancer development and progression as many of their clients are well established oncoproteins in multiple tumor types. Interestingly, tumor cells are more HSP chaperonage-dependent than normal cells for proliferation and survival because the oncoproteins in cancer cells are often misfolded and require augmented chaperonage activity for correction. Read More

    Predicting and managing sepsis in burn patients: current perspectives.
    Ther Clin Risk Manag 2017 29;13:1107-1117. Epub 2017 Aug 29.
    Department of Surgery, University of Texas Medical Branch.
    Modern burn care has led to unprecedented survival rates in burn patients whose injuries were fatal a few decades ago. Along with improved survival, new challenges have emerged in the management of burn patients. Infections top the list of the most common complication after burns, and sepsis is the leading cause of death in both adult and pediatric burn patients. Read More

    Hand Reconstruction After Burn Injury: Functional Results.
    Clin Plast Surg 2017 Oct 21;44(4):833-844. Epub 2017 Jul 21.
    ETHIANUM - Clinic for Plastic, Reconstructive & Aesthetic Surgery, Orthopedic Surgery, Partner Hospital of Heidelberg University, Voßstr. 6, 69115 Heidelberg, Germany. Electronic address:
    Frequently burns of the hand occur as part of a major thermal injury, but appropriate treatment of the hands has high priority, because even small burns of the hand may result in severely limited function and compromised aesthetic appearance. The functional importance of the hand cannot be overemphasized, because the patient's ability to perform useful work after recovery or the ability to care for themselves is to a great degree determined by residual hand function. This article describes the management of burn injuries involving the hand, stressing the importance of appropriate initial treatment. Read More

    Quantifying the efficacy of first aid treatments for burn injuries using mathematical modelling and in vivo porcine experiments.
    Sci Rep 2017 Sep 7;7(1):10925. Epub 2017 Sep 7.
    Centre for Children's Burns and Trauma Research, QUT, Institute of Health and Biomedical Innovation at the Centre for Children's Health Research, South Brisbane, Australia.
    First aid treatment of burns reduces scarring and improves healing. We quantify the efficacy of first aid treatments using a mathematical model to describe data from a series of in vivo porcine experiments. We study burn injuries that are subject to various first aid treatments. Read More

    Modeling Burns for Pre-Cooled Skin Flame Exposure.
    Int J Environ Res Public Health 2017 Sep 7;14(9). Epub 2017 Sep 7.
    Department of Engineering, Western Norway University of Applied Sciences, 5528 Haugesund, Norway.
    On a television show, a pre-cooled bare-skinned person (TV host) passed through engulfing kerosene flames. The assumption was that a water film should protect him during 0.74 s flame exposure in an environment of 86 kW/m² heat flux. Read More

    [Thermal injuries : Clinical and acute management in pediatric practice].
    Hautarzt 2017 Oct;68(10):784-789
    Kinderchirurgie und -urologie, Zentrum für schwerbrandverletzte Kinder, Kinder- und Jugendkrankenhaus AUF DER BULT, Janusz-Korczak-Allee 12, 30173, Hannover, Deutschland.
    Background: Each year 30,000 children suffer from burn injuries in Germany and 2000 of these children must be treated in special pediatric burn centers. Approximately two thirds of these children are less than 4 years old, 70% of thermal injuries are due to scalding with hot liquids.

    Objectives: The aim of this article is to give an overview of the characteristics of pediatric burn trauma with recommendations for initial treatment, surgical therapy as well as follow-up treatment. Read More

    MICROMYCETES INFECTION IN PATIENTS WITH THERMAL TRAUMA.
    Acta Chir Plast 2017 ;59(1):27-32
    Goal: Determination of basic epidemiological parameters of burn patients with micromycetes infection. Identification of the most important micromycetes in burn patients.

    Material And Methods: Monocentre retrospective study enrolling all adult burn patients who were hospitalized between 2007 and 2015 and in whom micromycetes were isolated during hospitalization. Read More

    MEEK MICROGRAFTING TECHNIQUE AND ITS USE IN THE TREATMENT OF SEVERE BURN INJURIES AT THE UNIVERSITY HOSPITAL OSTRAVA BURN CENTER.
    Acta Chir Plast 2017 ;59(1):11-17
    Background: Early necrectomy and skin autotransplantation are prerequisites for successful treatment of extensive burns. Insufficient autograft donor site availability is a limiting factor. The Meek micrografting technique, published by C. Read More

    Toxic shock syndrome in paediatric thermal injuries: A case series and systematic literature review.
    Burns 2017 Aug 31. Epub 2017 Aug 31.
    Pediatric Burns Center, Plastic and Reconstructive Surgery, Department of Paediatric Surgery, University Children's Hospital Zurich, Switzerland; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
    Background: Toxic shock syndrome (TSS) is a rare, but potentially life-threatening complication of thermal injuries in children. The study objective was to systematically review the literature on paediatric TSS after burns or scalds, and describe our experience with this condition in Switzerland.

    Methods: All tertiary paediatric healthcare centres managing burns and scalds in Switzerland were inquired. Read More

    Back to Basics: Pneumatic Tourniquet Use.
    AORN J 2017 Sep;106(3):219-226
    Pneumatic tourniquets are commonly used in surgeries involving the limbs to achieve a nearly bloodless surgery and an optimal operating field or when administering regional anesthesia during surgery on a limb. Complications can arise from the use of tourniquets, including nerve injuries, pain, compartment syndrome, pressure injuries, chemical burns, and tissue necrosis. More serious injuries-including deep vein thrombosis, thermal damage to tissues, severe ischemic injuries, and rhabdomyolysis-also can occur. Read More

    Leaving moss and litter layers undisturbed reduces the short-term environmental consequences of heathland managed burns.
    J Environ Manage 2017 Dec 3;204(Pt 1):102-110. Epub 2017 Sep 3.
    Centre for Ecology and Hydrology, Bush Estate, Penicuik, Midlothian, EH26 0QB, UK.
    Variation in the structure of ground fuels, i.e. the moss and litter (M/L) layer, may be an important control on fire severity in heather moorlands and thus influence vegetation regeneration and soil carbon dynamics. Read More

    A randomized study to evaluate the analgesic efficacy of a single dose of the TRPV1 antagonist mavatrep in patients with osteoarthritis.
    Scand J Pain 2017 Aug 24;17:134-143. Epub 2017 Aug 24.
    Janssen Research & Development, LLC, Titusville, NJ, USA.
    Background/aims: Transient receptor potential vanilloid type 1 (TRPV1) receptor antagonists have been evaluated in clinical studies for their analgesic effects. Mavatrep, a potent, selective, competitive TRPV1 receptor antagonist has demonstrated pharmacodynamic effects consistent with target engagement at the TRPV1 receptor in a previous single-dose clinical study. The current study was conducted to evaluate the analgesic effects of a single dose of mavatrep. Read More

    Calibration and performance of synchronous SIM/scan mode for simultaneous targeted and discovery (non-targeted) analysis of exhaled breath samples from firefighters.
    J Chromatogr A 2017 Sep 28;1516:114-124. Epub 2017 Jul 28.
    Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA.
    Traditionally, gas chromatography-mass spectrometry (GC/MS) analysis has used a targeted approach called selected ion monitoring (SIM) to quantify specific compounds that may have adverse health effects. Due to method limitations and the constraints of preparing duplicate samples, the information that could be obtained from separately collecting the full scan chromatogram of the sample has often been sacrificed. However, the hybrid technique called synchronous SIM/scan mode alternates between the two acquisition modes, maintaining the accuracy and sensitivity of SIM for targeted analysis while also providing the full scan chromatogram for discovery of non-target compounds. Read More

    Millimeter-wave emissivity as a metric for the non-contact diagnosis of human skin conditions.
    Bioelectromagnetics 2017 Oct 24;38(7):559-569. Epub 2017 Aug 24.
    Royal Manchester Children's Hospital, Manchester, United Kingdom.
    A half-space electromagnetic model of human skin over the band 30-300 GHz was constructed and used to model radiometric emissivity. The model showed that the radiometric emissivity rose from 0.4 to 0. Read More

    Protease loaded permeation enhancer liposomes for treatment of skin fibrosis arisen from second degree burn.
    Biomed Pharmacother 2017 Oct 8;94:747-757. Epub 2017 Aug 8.
    SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, C.G. 495009, India. Electronic address:
    Cysteine protease (papain) is a plant derived enzyme and due to its collagenolytic activity has potential in fibrosis reduction. However, a major hurdle in its use as fibrosis reducing agent is to overcome stratum corneum skin barrier via topical application, owing to its hydrophilic and high molecular weight and protein nature which is prone to degradation. The aim of the present study was to develop a penetration enhancer incorporated drug delivery system, i. Read More

    Influences of Macrohemodynamic Conditions on Systemic Microhemodynamic Changes in Burns.
    Ann Plast Surg 2016 Nov;77(5):523-528
    From the Department of Hand, Plastic and Reconstructive Surgery Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Heidelberg, Germany.
    Purpose: The clinical course after major burns is characterized by microcirculatory changes and consecutive capillary leakage. However, current clinical monitoring does not properly assess microcirculation, whereas macrohemodynamic changes are continuously evaluated. Here, we assess if macrohemodynamic and microhemodynamic parameters after burn trauma are correlated in a rat model. Read More

    Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections.
    Sci Rep 2017 Aug 8;7(1):7520. Epub 2017 Aug 8.
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
    Treatment of prosthetic joint infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibiotic therapy, due to the formation of biofilm. We introduce a non-invasive method for thermal destruction of biofilm on metallic implants using high-frequency (>100 kHz) alternating magnetic fields (AMF). In vitro investigations demonstrate a >5-log reduction in bacterial counts after 5 minutes of AMF exposure. Read More

    The Importance of First Aid to Burned Patients: 30 Years of Experience at the Burns Centre in Pisa.
    Open Access Maced J Med Sci 2017 Jul 23;5(4):420-422. Epub 2017 Jul 23.
    Universitario di Ruolo, Dipartimento di Scienze Dermatologiche, Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia, Dermatology, Via Vittoria Colonna 11, Rome 00186, Italy.
    The first aids to burned patients are fundamental for the evolution of the disease and the success of the next medical care in a Burns Center. In our 30-years experience, we can reassume that they must be provided to limit the cause of thermal damage, to evaluate and correct eventual respiratory or cardiovascular disorders, to find out the possible damage to different organs and the primary care on cutaneous lesions. Read More

    Justification for a Nuclear Global Health Workforce: multidisciplinary analysis of risk, survivability & preparedness, with emphasis on the triage management of thermal burns.
    Confl Health 2017 1;11:13. Epub 2017 Aug 1.
    Institute for Disaster Management, Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA USA.
    Major challenges and crises in global health will not be solved by health alone; requiring rather a multidisciplinary, evidence-based analytical approach to prevention, preparedness and response. One such potential crisis is the continued spread of nuclear weapons to more nations concurrent with the increased volatility of international relations that has significantly escalated the risk of a major nuclear weapon exchange. This study argues for the development of a multidisciplinary global health response agenda based on the reality of the current political analysis of nuclear risk, research evidence suggesting higher-than-expected survivability risk, and the potential for improved health outcomes based on medical advances. Read More

    Antinociceptive effects of pluronic lecithin organo (PLO)-opioid gels in rats with thermal injury.
    Burns 2017 Aug 1. Epub 2017 Aug 1.
    Burn Injuries Task Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, San Antonio Military Medical Center, Fort Sam Houston, TX 78234, United States. Electronic address:
    Opioids are extensively used as analgesics to control burn pain. However, systemic administration of opioids induces multiple adverse effects that are primarily CNS mediated. Alternately, topical application of low dose of opioids directly at the site of injury could attenuate pain while avoiding CNS-mediated side effects. Read More

    200mM hypertonic saline resuscitation attenuates intestinal injury and inhibits p38 signaling in rats after severe burn trauma.
    Burns 2017 Aug 1. Epub 2017 Aug 1.
    Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China. Electronic address:
    Background: An overabundant discharge of inflammatory mediators plays a significant role in intestinal injury throughout the early stages of critical burns. The present study aims to explore the outcome of 200mM hypertonic saline (HS) resuscitation on the intestinal injury of critically burned rats.

    Materials And Methods: Fifty-six Sprague-Dawley rats were randomized into three groups: sham group (group A), burn plus lactated Ringer's group (group B), and burn plus 200mM HS group (group C). Read More

    Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury.
    J Cell Biochem 2017 Aug 3. Epub 2017 Aug 3.
    Department of Burns and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
    Denatured dermis is a part of the dermis in deep burn wound and has the ability to restore normal morphology and function. In our previous study, we revealed that miR-29a downregulation in denatured dermis may help burn wound healing in the later phase, and further enhance type I collagen synthesis. LIN28A, a highly-conserved RNA binding protein expressed during embryogenesis, plays roles in development, pluripotency, metabolism, as well as tissue repair in adults. Read More

    Combined antibacterial/tissue regeneration response in thermal burns promoted by functional chitosan/silver nanocomposites.
    Int J Biol Macromol 2017 Dec 28;105(Pt 1):1241-1249. Epub 2017 Jul 28.
    Departamento de Polímeros y Biopolímeros, CINVESTAV Unidad Querétaro, Libramiento Norponiente No. 2000, Fracc. Real de Juriquilla, C.P. 76230, Querétaro, Mexico. Electronic address:
    We report the combined antibacterial/tissue regeneration responses to thermal burns promoted by functional chitosan/silver nanocomposites (CS/nAg) with ultralow silver content (0.018wt.%, 7-30nm). Read More

    Comparing the reported burn conditions for different severity burns in porcine models: a systematic review.
    Int Wound J 2017 Jul 23. Epub 2017 Jul 23.
    Centre for Children's Burns and Trauma Research, Queensland University of Technology, Institute of Health and Biomedical Innovation and Centre for Children's Health Research, South Brisbane, QLD, Australia.
    There are many porcine burn models that create burns using different materials (e.g. metal, water) and different burn conditions (e. Read More

    Scar formation following excisional and burn injuries in a red Duroc pig model.
    Wound Repair Regen 2017 Aug 31;25(4):618-631. Epub 2017 Jul 31.
    Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio.
    Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome. Read More

    Critical Evaluation of Metallization in Electric Injury.
    Am J Forensic Med Pathol 2017 Dec;38(4):333-335
    From the *Faculty of Medicine, Department of Pathology, Forensic Medicine and Pharmacology, Vilnius University, Vilnius; †State Forensic Medicine Service; and ‡Faculty of Fundamental Sciences, Department of Physics, Vilnius Gediminas Technical University, Vilnius, Lithuania.
    The article presents 3 forensic medicine cases in the field of electric injury. In addition to traditional findings in electric injury (electric mark and histological findings), the forensic medicine experts in Lithuania also perform an atomic absorption spectrometry analysis. This method confirms the effects of electric current to the body through the electric conductor. Read More

    Clean Power Generation from the Intractable Natural Coalfield Fires: Turn Harm into Benefit.
    Sci Rep 2017 Jul 13;7(1):5302. Epub 2017 Jul 13.
    School of Mechanical and Mining Engineering, The University of Queensland, Brisbane, QLD 4072, Australia.
    The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the world, which could generate ~1000 GW per annum. Read More

    Role of Daptomycin on Burn Wound Healing in an Animal Methicillin-Resistant Staphylococcus aureus Infection Model.
    Antimicrob Agents Chemother 2017 Sep 24;61(9). Epub 2017 Aug 24.
    Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy.
    Prolonged hospitalization and antibiotic therapy are risk factors for the development of methicillin-resistant Staphylococcus aureus (MRSA) infections in thermal burn patients. We used a rat model to study the in vivo efficacy of daptomycin in the treatment of burn wound infections by S. aureus, and we evaluated the wound healing process through morphological and immunohistochemical analysis. Read More

    Treatment of cervical intraepithelial lesions.
    Int J Gynaecol Obstet 2017 Jul;138 Suppl 1:20-25
    Edinburgh University, Edinburgh, UK.
    Precancerous cervical lesions precede the development of invasive cervical cancer by 10-20 years, making cervical cancer preventable if these lesions are detected and effectively treated. Treatment has evolved in the last few decades and now includes ablative options that can be performed in lower-resource settings where surgical excision is not feasible or routinely available. Gas-based cryotherapy, which freezes cervical tissue to induce localized necrosis, is the most commonly used ablative treatment. Read More

    Protective role of vitamin E preconditioning of human dermal fibroblasts against thermal stress in vitro.
    Life Sci 2017 Sep 3;184:1-9. Epub 2017 Jul 3.
    National Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan; Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan; Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan. Electronic address:
    Aims: Oxidative microenvironment of burnt skin restricts the outcome of cell based therapies of thermal skin injuries. The aim of this study was to precondition human dermal fibroblasts with an antioxidant such as vitamin E to improve their survival and therapeutic abilities in heat induced oxidative in vitro environment.

    Main Methods: Fibroblasts were treated with 100μM vitamin E for 24h at 37°C followed by heat shock for 10min at 51°C in fresh serum free medium. Read More

    Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital.
    BMC Res Notes 2017 Jul 6;10(1):258. Epub 2017 Jul 6.
    Plastics and Burns Unit, Department of Surgery, Mulago National Referral Hospital, P.O.BOX 7051, Kampala, Uganda.
    Background: Blood transfusion, a practice under re-evaluation in general, remains common among thermal burn patients due to the hematological alterations associated with burns that manifest as anemia. Today advocacy is for restrictive blood transfusion taking into account individual patient characteristics. We went out to identify the parameters that may determine transfusion requirement and the time to blood transfusion for thermal burn patients in Mulago Hospital in order to build statistics and a basis to standardize future practice and Hospital protocol. Read More

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