Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells.
BMC Immunol 2017 Feb 22;18(1). Epub 2017 Feb 22.
Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX, 77555-0877, USA.
Background: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. Read More