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    Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells.
    BMC Immunol 2017 Feb 22;18(1). Epub 2017 Feb 22.
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX, 77555-0877, USA.
    Background: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. Read More

    Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars.
    J Burn Care Res 2017 Feb 15. Epub 2017 Feb 15.
    From the *Center for Regenerative Medicine, Oregon Health & Science University, Portland; †Department of Surgery, Oregon Health & Science University, Portland; ‡Oregon Biomedical Engineering Institute, Wilsonville; §Nike, Inc., Beaverton, Oregon; ‖Department of Hematology, General Hospital of Ningxia Medical University, Yinchuan, China; and ¶CVPath Institute, Gaithersburg, Maryland.
    Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. Read More

    The biochemical alterations underlying post-burn hypermetabolism.
    Biochim Biophys Acta 2017 Feb 17. Epub 2017 Feb 17.
    Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada. Electronic address:
    A severe burn can trigger a hypermetabolic state which lasts for years following the injury, to the detriment of the patient. The drastic increase in metabolic demands during this phase renders it difficult to meet the body's nutritional requirements, thus increasing muscle, bone and adipose catabolism and predisposing the patient to a host of disorders such as multi-organ dysfunction and sepsis, or even death. Despite advances in burn care over the last 50 years, due to the multifactorial nature of the hypermetabolic phenomenon it is difficult if not impossible to precisely identify and pharmacologically modulate the biological mediators contributing to this substantial metabolic derangement. Read More

    Current techniques to treat pathologic perforator veins.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 16;5(2):293-296. Epub 2017 Jan 16.
    Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC. Electronic address:
    Pathologic perforating veins have become an interest to the venous specialist caring for patients with CEAP 4 to 6 disease. Historically, open perforator ligation and then subdermal endoscopic perforator ligation was described. These methods had clear shortcomings. Read More

    Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Rat Model: Protective Effect of Epigallocatechin Gallate.
    J Burn Care Res 2017 Feb 6. Epub 2017 Feb 6.
    From the *Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China; †Department of Anesthesiology, Chengdu Women and Children's Central Hospital, People's Republic of China; and ‡West China School of Medicine, Sichuan University, Chengdu, People's Republic of China.
    Lungs are easily damaged by the inflammatory responses induced after extensive burns. The aim here was to investigate the protective role of epigallocatechin gallate (EGCG) in mitochondrial DNA (mtDNA)-mediated inflammatory responses and acute respiratory distress syndrome (ARDS) in a rat model of thermal injury. Male Sprague-Dawley rats were randomly assigned to five groups. Read More

    Thermal Variations of Operative Microscopes in Otology.
    Otolaryngol Head Neck Surg 2017 Feb 1:194599817690118. Epub 2017 Feb 1.
    1 Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, New York, USA.
    Objectives (1) Measure temperature variations achieved by common otomicroscopes. (2) Raise awareness about possible thermal injury during otologic procedures with the advent of newer, high-powered otomicroscopes. (3) Describe optical technology that aims to reduce the potential for thermal injury. Read More

    Burns and frostbite in the Red Army during World War II.
    Mil Med Res 2017 8;4. Epub 2017 Feb 8.
    Department of Thermal Injuries of the S.M. Kirov Military Medical Academy, Major of Medical Service, Zagorodnyy Prospect, 47, 190013 Saint-Petersburg, Russia.
    The start of World War II (WWII) led to the deployment of combat troops in several continents. Destruction and many casualties among both the military and civilians became an inevitable consequence. A large amount of people injured were in need of life-saving treatment and a speedy return to duty. Read More

    Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in serum of children after thermal injury.
    Adv Med Sci 2017 Feb 10;62(1):83-86. Epub 2017 Feb 10.
    Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, Poland.
    Purpose: The study aims to determinate concentrations of ubiquitin C-terminal hydrolase 1 (UCHL1), which hydrolyzes amino acids from ubiquitin and cleave di-ubiquitins, in serum of children after thermal injury.

    Patients/methods: 42 children scalded by hot water, managed at the Department of Pediatric Surgery, with burns in 4-20% TBSA were included into the study (age 9 months up to 14 years, mean age 2.5±1 years). Read More

    Neurologic complications of acute environmental injuries.
    Handb Clin Neurol 2017 ;141:685-704
    Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
    Environmental injuries can result in serious neurologic morbidity. This chapter reviews neurologic complications of thermal burns, smoke inhalation, lightning strikes, electric injury, near drowning, decompression illness, as well as heat stroke and accidental hypothermia. Knowing the pathophysiology and clinical presentation of such injuries is essential to proper management of primary and secondary medical complications. Read More

    Caregiver-related predictors of thermal burn injuries among Iranian children: A case-control study.
    PLoS One 2017 2;12(2):e0170982. Epub 2017 Feb 2.
    Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran.
    Purpose: Burns are a common and preventable cause of injury in children. The aim of this study was to investigate child and caregiver characteristics which may predict childhood burn injuries among Iranian children and to examine whether confounding exists among these predictors.

    Methods: A hospital based case-control study was conducted using 281 burn victims and 273 hospital-based controls, which were matched by age, gender and place of residence (rural/urban). Read More

    Extensive burn injury caused by fundamental electronic cigarette design flaw.
    Ann Burns Fire Disasters 2016 Sep;29(3):231-233
    Department of Plastic and Hand Surgery - Burn Centre, University Clinics RWTH Aachen, Germany.
    Currently, electronic cigarette (EC) devices are widely used as an alternative to conventional smoking. The underlying technical principle is an electric coil-based vaporizer unit, which vaporizes various solutions for inhalation purposes with a rechargeable lithium battery unit as power source. We report a case of extensive burn injury resulting from the thermal explosion of a battery unit within an EC device. Read More

    Long-term outcome of allogeneic cultivated limbal epithelial transplantation for symblepharon caused by severe ocular burns.
    BMC Ophthalmol 2017 Jan 31;17(1). Epub 2017 Jan 31.
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, 5 Yanerdao Road, 266071, Qingdao, China.
    Background: The therapeutic effects of allogeneic cultivated limbal epithelial transplantation (CLET) for symblephara at different degrees caused by ocular burns were evaluated in this study.

    Methods: A series of interventional cases were involved in this retrospective study. Eighty eyes (80 patients) with symblephara underwent CLET and the success rates of surgical treatment as well as corneal conditions and risk factors for recurrent symblepharon were analyzed. Read More

    Thermal injury patterns associated with electronic cigarettes.
    Int J Burns Trauma 2017 15;7(1):1-5. Epub 2017 Jan 15.
    U.S. Army Institute of Surgical Research Fort Sam Houston, Texas, United States of America.
    E-cigarettes are typically lithium-ion battery-operated devices that simulate smoking by heating a nicotine-solution into a vapor that the user inhales. E-cigarette use is becoming rapidly popular as an alternative to traditional cigarette smoking. This report describes an emerging problem associated with e-cigarettes, consisting of 10 thermally injured patients seen at a single burn center over a 2-year period from 2014 to 2016. Read More

    The involvement of endoplasmic reticulum stress response in immune dysfunction of dendritic cells after severe thermal injury in mice.
    Oncotarget 2017 Feb;8(6):9035-9052
    State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing, China.
    Suppressed adaptive immune function is one of the major concerns responsible for the development of opportunistic infections and subsequent sepsis with high mortality in severe burns. Endoplasmic reticulum stress (ERS) is the endogenous self-protective mechanism, and it plays an important role in almost every process of living by regulating the balance between homeostasis and apoptosis. The current study investigated the involvement of ERS in the pathogenesis of dysfunction of dendritic cells (DCs) in burn mice. Read More

    Effect of thermal annealing Super Yellow emissive layer on efficiency of OLEDs.
    Sci Rep 2017 Jan 20;7:40805. Epub 2017 Jan 20.
    School of Chemistry Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane QLD 4000, Australia.
    Thermal annealing of the emissive layer of an organic light emitting diode (OLED) is a common practice for solution processable emissive layers and reported annealing temperatures varies across a wide range of temperatures. We have investigated the influence of thermal annealing of the emissive layer at different temperatures on the performance of OLEDs. Solution processed polymer Super Yellow emissive layers were annealed at different temperatures and their performances were compared against OLEDs with a non-annealed emissive layer. Read More

    [Analysis of microRNA expression profile in serum of patients with electrical burn or thermal burn].
    Zhonghua Shao Shang Za Zhi 2017 Jan;33(1):37-42
    Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430060, China.
    Objective: To explore the differential expression of microRNAs in the serum among patients with electrical burn or thermal burn and healthy persons and to explore the significance. Methods: In this study we included three patients with electrical burn and three patients with thermal burn, conforming to the inclusion criteria and hospitalized in our burn ward from June to August 2015, and three healthy adult volunteers. Their serum samples were separated from whole blood and divided into electrical burn group, thermal burn group, and normal control group. Read More

    At-a-glance, Emergency department surveillance of thermal burns and scalds, electronic Canadian Hospitals Injury Reporting and Prevention Program, 2013.
    Health Promot Chronic Dis Prev Can 2017 Jan;37(1):30-31
    Public Health Agency of Canada, Ottawa, Ontario, Canada.
    Introduction: Although fatality and hospitalization rates for burns in Canada have declined over time, less serious cases still commonly present to the emergency department (ED).

    Methods: The Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) is an injury and poisoning surveillance system administered by the Public Health Agency of Canada, operating in emergency departments of 17 hospitals.

    Results: Overall, cases reported in 2013 were scalds and contact burns from hot objects. Read More

    Lower-Limb Muscular Strength, Balance, and Mobility Levels in Adults Following Severe Thermal Burn Injuries.
    J Burn Care Res 2017 Jan 10. Epub 2017 Jan 10.
    From the *Physical Therapy Department for Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt; and †Collage of Applied Medical Science (CAMS) - Majmaah University, Al Majmaah, Kingdom of Saudi Arabia.
    Severe burn injuries are associated with hypermetabolic response and increased catabolism. These lead to a vast loss of muscle mass and reduced muscle strength and function. Therefore, the aim of this study is to determine the impact of severe burn injuries on lower-limb muscular strength, balance, and mobility level in adults. Read More

    Thermography-based blood flow imaging in human skin of the hands and feet: a spectral filtering approach.
    Physiol Meas 2017 Feb 18;38(2):272-288. Epub 2017 Jan 18.
    Department of Nano and Biomedical Technology, Saratov State University, Astrakhanskaya st. 83, Saratov 410012, Russia.
    The determination of the relationship between skin blood flow and skin temperature dynamics is the main problem in thermography-based blood flow imaging. Oscillations in skin blood flow are the source of thermal waves propagating from micro-vessels toward the skin's surface, as assumed in this study. This hypothesis allows us to use equations for the attenuation and dispersion of thermal waves for converting the temperature signal into the blood flow signal, and vice versa. Read More

    Contemporary Methods Allowing for Safe and Convenient Use of Amniotic Membrane as a Biologic Wound Dressing for Burns.
    Ann Plast Surg 2017 Feb;78(2 Suppl 1):S9-S10
    From the *Department of Surgery, The University of Texas Medical Branch, Galveston, TX; and †Shriners Hospitals for Children, Galveston, TX.
    Partial-thickness burns involve damage to the upper layer of skin, which leaves nerve endings exposed, and therefore represent the most painful of several categories of thermal injuries. Historically, partial-thickness burns were treated conservatively by debriding the blisters, by daily tubbing and washing, and the application of new bandages with topical medications. Human amniotic membrane has been used for centuries as a biological wound dressing. Read More

    Prevalence and severity of bone loss in burned patients.
    Burns 2017 Jan 6. Epub 2017 Jan 6.
    Shiraz University of Medical Sciences, Shiraz, Iran.
    Often discovered late during the clinical course of burns, bone loss is widely accepted by clinicians as a de facto consequence of burn. Literature on this bone loss is limited and contradictory in details. More insight into the prevalence and magnitude of bone loss may facilitate its prevention. Read More

    Endoscopic ear surgery: a hot topic?
    J Laryngol Otol 2017 Feb 10;131(2):117-122. Epub 2017 Jan 10.
    Department of Otolaryngology,Queen Elizabeth Hospital,University Hospitals Birmingham NHS Foundation Trust,UK.
    Objectives: To summarise published research investigating maximal temperatures associated with endoscopes used in otology. Possible thermal issues surrounding the use of endoscopes in middle-ear surgery are discussed, and recommendations regarding the safest ways to use endoscopes in endoscopic ear surgery are made.

    Methods: A non-systematic review of the relevant literature was conducted, with descriptive analysis and presentation of the results. Read More

    Assessment of acute thermal damage volumes in muscle using magnetization-prepared 3D T2 -weighted imaging following MRI-guided high-intensity focused ultrasound therapy.
    J Magn Reson Imaging 2017 Jan 9. Epub 2017 Jan 9.
    Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA.
    Purpose: To evaluate magnetization-prepared 3D T2 -weighted magnetic resonance imaging (MRI) measurements of acute tissue changes produced during ablative MR high-intensity focused ultrasound (MR-HIFU) exposures.

    Materials And Methods: A clinical MR-HIFU system (3T) was used to generate thermal lesions (n = 24) in the skeletal muscles of three pigs. T1 -weighted, 2D T2 -weighted, and magnetization-prepared 3D T2 -weighted sequences were acquired before and after therapy to evaluate tissue changes following ablation. Read More

    Cyanoacrylate Burn Injuries: Two Unusual Cases and a Review of the Literature.
    Wounds 2016 Dec;28(12):E53-E59
    Burns Unit, Chelsea and Westminster Hospital, London, UK.
    The authors present 2 cases of cyanoacrylate glue ("Super Glue") burns, with a review of the literature and a discussion on the mechanism of action. The authors found all reported cases were with domestic - not medical-grade - cyanoacrylate glue in the presence of cotton fabric. Often erroneously designated as chemical burns, they are thermal burns caused by an intensive exothermic reaction. Read More

    A Literature Review of Burns in Reconstructed Breasts After Mastectomy.
    Wounds 2016 Dec;28(12):422-428
    The Burn Unit, Department of Plastic and Reconstructive Surgery, Sheba Medical Center (Affiliated to Sackler School of Medicine, Tel-Aviv University); and The Talpiot Medical Leadership Program, Sheba Medical Center, Ramat Gan, Israel.
    Objective: The goal of this literature review is to review and combine case studies of accidental burns to the breast, following mastectomy and immediate breast reconstruction with autologous tissue, implants, or tissue expanders.

    Methods: The authors searched PubMed and Cochrane Library and reviewed cases of burns of reconstructed breasts after mastectomy from July 1985 to May 2015. Only studies in the English language were included in their search. Read More

    A retrospective analysis of patients with head and neck cancer treated with radiation, hyperthermia, and cetuximab: A brief report of outcome.
    J Cancer Res Ther 2016 Jul-Sep;12(3):1164-1166
    Department of Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.
    Purpose: Advanced head and neck cancer continues to have a dismal outcome. Chemoradiation remains the current standard of care. Chemoradiation has not achieved the desired increase in survival in locally advanced head and neck cancer. Read More

    Role of the NLRP3 inflammasome in a model of acute burn-induced pain.
    Burns 2017 Mar 28;43(2):304-309. Epub 2016 Dec 28.
    IMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd. (Building 80), St Lucia, Queensland 4072, Australia; School of Pharmacy, Pharmacy Australia Centre of Excellence, 20 Cornwall St., Woolloongabba, Queensland 4102, Australia. Electronic address:
    The NLRP3 inflammasome is a multi-protein complex that assembles in response to tissue damage or infection, triggering activation of caspase-1, an enzyme that converts interleukin (IL)-1β into its active form. A role for the NLRP3 inflammasome is emerging in inflammatory pain, but its influence in other pain types is largely unexamined. Therefore the aim of this study was to assess the role of the NLRP3 inflammasome and its downstream product caspase-1 in a model of acute burn-induced pain in male mice. Read More

    Adjunctive hyperbaric oxygen therapy in severe burns: Experience in Taiwan Formosa Water Park dust explosion disaster.
    Burns 2016 Dec 26. Epub 2016 Dec 26.
    Hyperbaric Oxygen Therapy Center, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address:
    Background: Despite major advances in therapeutic strategies for the management of patients with severe burns, significant morbidity and mortality is observed. Hyperbaric oxygen therapy (HBOT) increases the supply of oxygen to burn areas. The aim of this study was to determine whether HBOT is effective in the treatment of major thermal burns. Read More

    Management of Burn Injuries in the Wilderness: Lessons from Low-Resource Settings.
    Wilderness Environ Med 2016 Oct 28. Epub 2016 Oct 28.
    Department of Surgery, Division of Emergency Medicine and the College of Public Health and Social Justice, Saint Louis University, St. Louis, MO (Dr Bitter); and the Department of Emergency Medicine, Division of Toxicology, Brigham & Women's Hospital, Harvard Medical School, Harvard Humanitarian Initiative, Boston MA (Dr Erickson).
    Burns are a common source of injuries worldwide, with a high burden of disease in low- and middle-income countries. Burns also account for 2%-8% of wilderness injuries. Although many are minor, the potential for serious morbidity and mortality exists, and standard treatments used in high-resource settings are not readily available in the backcountry. Read More

    Important Developments in Burn Care.
    Plast Reconstr Surg 2017 Jan;139(1):120e-138e
    Toronto, Ontario, and Edmonton, Alberta, Canada From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto; and the Divisions of Plastic and Reconstructive Surgery and Critical Care, Department of Surgery, University of Alberta.
    Learning Objectives: After studying this article, the participant should be able to: 1. Explain the epidemiology of severe burn injury in the context of socioeconomic status, gender, age, and burn cause. 2. Read More

    Circulating Microvesicles Are Elevated Acutely following Major Burns Injury and Associated with Clinical Severity.
    PLoS One 2016 9;11(12):e0167801. Epub 2016 Dec 9.
    Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery & Cancer, Imperial College London, London, United Kingdom.
    Microvesicles are cell-derived signaling particles emerging as important mediators and biomarkers of systemic inflammation, but their production in severe burn injury patients has not been described. In this pilot investigation, we measured circulating microvesicle levels following severe burns, with severe sepsis patients as a comparator group. We hypothesized that levels of circulating vascular cell-derived microvesicles are elevated acutely following burns injury, mirroring clinical severity due to the early onset and prevalence of systemic inflammatory response syndrome (SIRS) in these patients. Read More

    Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models.
    Burns 2016 Dec 5. Epub 2016 Dec 5.
    Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA. Electronic address:
    Thermal injury to skin and subcutaneous tissue is common in both civilian and combat scenarios. Understanding the change in tissue morphologies and properties and the underlying mechanisms of thermal injury are of vital importance to clinical determination of the degree of burn and treatment approach. This review aims at summarizing the research involving experimental and numerical studies of skin and subcutaneous tissue subjected to thermal injury. Read More

    Lakartidningen 2016 Dec 1;113. Epub 2016 Dec 1.
    Arbets- och miljömediciin - Universitetssjukhuset Örebro, Sweden Arbets- och miljömediciin - Universitetssjukhuset Örebro, Sweden.
    Immediate and delayed outcomes after electrical injury. A guide for clinicians In Sweden about 300 electrical injuries are recorded each year at the Swedish National Electrical Safety Board. Most of our knowledge of the health consequences of these arise from clinical case series. Read More

    Hyperthermia, Thermal Injuries, and Death from a Forced Convection Heat Source: A Case Report and Experimental Model.
    J Forensic Sci 2016 Dec 6. Epub 2016 Dec 6.
    Department of Pathology, University of Michigan, 1301 Catherine Street, Ann Arbor, MI, 48109.
    Heat-related deaths of children are most often encountered in the context of enclosed vehicles in summer months. Deviating from this, a 16-month-old boy was found unresponsive in a stroller that was placed adjacent to a space heater during mid-winter. The cause of death was hyperthermia and thermal injuries. Read More

    Ultra-Early versus Early Excision and Grafting for Thermal Burns up to 60% Total Body Surface Area; A Historical Cohort Study.
    Bull Emerg Trauma 2016 Oct;4(4):197-201
    Student Research Committee, Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran.
    Objective: To compare the outcome of patients with up to 60% total body surface area (TBSA) thermal burns undergoing ultra-early and early excision and grafting.

    Methods: This historical cohort study was performed in two referral burn centers of Shiraz during a 1-year period from 2015 to 2016. We included those patients with thermal burns up to 60% TBSA who underwent ultra-early (48-72 hours) and early (7-10 days) excision and grafting. Read More

    Fluid resuscitation mediates the association between inhalational burn injury and acute kidney injury in the major burn population.
    J Crit Care 2016 Oct 19;38:62-67. Epub 2016 Oct 19.
    Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address:
    Background: It is known that acute respiratory distress syndrome and acute lung injury are independent risk factors for developing acute kidney injury (AKI) through complex pathophysiologic mechanisms. Our specific aim is to evaluate the risk factors for AKI postburn injury and whether inhalation thermal injury is an independent risk factor for developing AKI in the major burn population.

    Methods: This is an institutional review board-approved, retrospective cohort study of patients admitted to a tertiary burn intensive care unit between 2011 and 2013. Read More

    Effects of target-controlled infusion of high-dose naloxone on pain and hyperalgesia in a human thermal injury model: a study protocol: A randomized, double-blind, placebo-controlled, crossover trial with an enriched design.
    Medicine (Baltimore) 2016 Nov;95(46):e5336
    aNeuroscience Center, Copenhagen University Hospitals, Copenhagen, Denmark bDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
    Mu-opioid-receptor antagonists have been extensively studied in experimental research as pharmacological tools uncovering mechanisms of pain modulation by the endogenous opioid system. In rodents, administration of high doses of mu-opioid-receptor antagonists after the resolution of an inflammatory injury has demonstrated reinstatement of nociceptive hypersensitivity indicating unmasking of latent sensitization. In a recent human study, pain hypersensitivity assessed as secondary hyperalgesia area (SHA), was reinstated 7 days after a mild thermal injury, in 4 out of 12 subjects after a naloxone infusion. Read More

    The thermal probe test: A novel behavioral assay to quantify thermal paw withdrawal thresholds in mice.
    Temperature (Austin) 2016 Apr-Jun;3(2):199-207. Epub 2016 Feb 26.
    Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia.
    Rodent models are frequently used to improve our understanding of the molecular mechanisms of pain and to develop novel analgesics. Robust behavioral assays that quantify nociceptive responses to different sensory modalities, such has heat, are therefore needed. Here, we describe a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice, called the thermal probe test, and compared it with other methods commonly used to measure heat thresholds, namely the Hargreaves test and the dynamic and conventional hot plate tests. Read More

    Immediate tangential excision accelerates wound closure but does not reduce scarring of mid-dermal porcine burns.
    Ann Burns Fire Disasters 2016 Mar;29(1):54-61
    Department of Biomedical Engineering, Stony Brook University, New York, USA; Department of Dermatology, Stony Brook University, New York, USA.
    Current evidence supports the use of excision to remove eschar from deep dermal and full-thickness burns. However, the role of excision of mid-dermal burns remains unclear. This study aimed to develop a porcine model that could produce reproducible middermal thermal burns that undergo tangential excision; and investigate the effects of immediate tangential excision (30 minutes postburn) on healing and scarring. Read More

    Overview of ethno-folkloric burns in the Republic of Slovenia.
    Ann Burns Fire Disasters 2016 Mar;29(1):9-13
    University Medical Centre, Department of Plastic Surgery and Burns, Ljubljana, Slovenia.
    The article describes typical folkloric- and ethnographic-related burns/scalds in Slovenia. All of the mentioned burns/scalds derive from the life of a nation, and are primarily a result of specific customs, traditions and activities carried out in a rural environment. Prolonged periods of lying on a hot tiled wood burner results in deep contact burns. Read More

    Superficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy Under Limited Access and Conventional Dressings.
    World J Plast Surg 2016 Sep;5(3):265-273
    Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India.
    Background: Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. Read More

    Cold burn injuries in the UK: the 11-year experience of a tertiary burns centre.
    Burns Trauma 2016 11;4:36. Epub 2016 Nov 11.
    St Andrew Plastics and Burns Unit, Court Road, Chelmsford, CM1 7ET UK.
    Background: Guidance for the management of thermal injuries has evolved with improved understanding of burn pathophysiology. Guidance for the management of cold burn injuries is not widely available. The management of these burns differs from the standard management of thermal injuries. Read More

    Thermal analyses of in vitro low frequency sonophoresis.
    Ultrason Sonochem 2017 Mar 2;35(Pt A):458-470. Epub 2016 Nov 2.
    State Key Lab of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China.
    As a type of transdermal drug delivery method, low frequency sonophoresis (LFS) has been investigated during the last twenty years and is currently being attempted in a clinical setting. However, the safety of low frequency ultrasound on humans has not been completely guaranteed with high-intensity ultrasound. Thermal damage, one of the challenges in the LFS process, e. Read More

    Thermal Injury to Reconstructed Breasts from Commonly Used Warming Devices: A Risk for Reconstructive Failure.
    Plast Reconstr Surg Glob Open 2016 Oct 27;4(10):e1033. Epub 2016 Oct 27.
    Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
    Background: Sensation is decreased or absent after breast reconstruction. This leaves reconstructed breasts vulnerable to injury from common household thermal sources such as heating pads and hot water bottles. We sought to categorize these injuries, provide a treatment plan, and prevent these injuries in the future. Read More

    Blockade of IgM-Mediated Inflammation Alters Wound Progression in a Swine Model of Partial-Thickness Burn.
    J Burn Care Res 2016 Oct 27. Epub 2016 Oct 27.
    From the *Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; †Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown; and ‡Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, Los Angeles.
    In a mouse model, a second-degree burn elicits a severe inflammatory response that is mediated by circulating autoantibody specific for a neoantigen (nonmuscle myosin). Nonmuscle myosin is expressed by injured tissue, leading to amplified ulceration and scarring. We hypothesize that a synthetic peptide (N2) can mimic the neoantigen and competitively inhibit the autoantibody, decreasing inflammation, and reducing the extent of burn injury in a preclinical swine model of burn. Read More

    Clinical Spectrum and Treatment Approaches in Corneal Burns.
    Turk J Ophthalmol 2015 Oct 5;45(5):182-187. Epub 2015 Oct 5.
    Dünya Eye Hospital, Ankara, Turkey.
    Objectives: To evaluate the clinical findings, treatment modalities and long-term prognosis of chemical and thermal burns of the cornea.

    Materials And Methods: Twenty-one patients (27 eyes) who were followed at two centers for corneal chemical and thermal burns between 2001 and 2013 were included. Eyes were grouped into four grades according to the severity of burn using Roper-Hall classification. Read More

    Platinum Nanoparticle Decorated SiO2 Microfibers as Catalysts for Micro Unmanned Underwater Vehicle Propulsion.
    ACS Appl Mater Interfaces 2016 Nov 1;8(45):30941-30947. Epub 2016 Nov 1.
    Department of Mechanical Engineering, Iowa State University , Ames, Iowa 50011, United States.
    Micro unmanned underwater vehicles (UUVs) need to house propulsion mechanisms that are small in size but sufficiently powerful to deliver on-demand acceleration for tight radius turns, burst-driven docking maneuvers, and low-speed course corrections. Recently, small-scale hydrogen peroxide (H2O2) propulsion mechanisms have shown great promise in delivering pulsatile thrust for such acceleration needs. However, the need for robust, high surface area nanocatalysts that can be manufactured on a large scale for integration into micro UUV reaction chambers is still needed. Read More

    [The role of neutrophil myeloperoxidase in the development of inflammation after thermal skin burns].
    Biomed Khim 2016 Jul;62(5):584-587
    Federal Scientific Clinical Centre of Physical Chemical Medicine, Moscow, Russia.
    In the blood of children (n=16) with large thermal skin burns (> 20% of total body surface), luminol-dependent chemiluminescence (CL) of neutrophils stimulated with phorbol-12-myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity in neutrophils and plasma were assayed in the early period (1-7 post-burn days). PMA-stimulated neutrophils in thermally injured patients produced higher CL than those in a reference group of healthy children (n=24), p<0.01. Read More

    Fungal Infection in Thermal Burns: A Prospective Study in a Tertiary Care Centre.
    J Clin Diagn Res 2016 Sep 1;10(9):PC05-PC07. Epub 2016 Sep 1.
    Student, Government Medical College , Amritsar, Punjab, India .
    Introduction: Burn Wound Infection (BWI) is primarily caused by aerobic bacteria followed by fungi, anaerobes and viruses. There has been a worldwide decrease in incidence of bacterial infections in burns due to better patient care and availability of effective antibiotics. Consequently, the fungal burn wound infection has shown an increasing trend. Read More

    Quantifying inadvertent thermal bowel injury from the monopolar instrument.
    Surg Endosc 2016 Nov 29;30(11):4776-4784. Epub 2016 Apr 29.
    Department of Surgery, University of Colorado Anschutz Medical School, Aurora, CO, USA.
    Background: Insulation defects are observed in 3-39 % of laparoscopic instruments. Electrosurgical injuries due to insulation defects or capacitive coupling remain an issue in laparoscopic surgery with a prevalence of 0.6-5 per thousand cases. Read More

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