Search Our Scientific Publications & Authors

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.

The aim of this review is to map and summarize the experiences of various burn centers worldwide during the COVID-19 pandemic, in order to enable future strategies with regard to the most effective measures in burn care during pandemics and to detect possible gaps in knowledge. The coronavirus disease 2019 (COVID-19) pandemic had a major impact on economies, social interactions, and health systems worldwide. Burn units all over the world face a new challenge in maintaining the care of acute burn wounds and follow-up treatments while dealing with constantly changing regulations. Read More

Blood Purif 2022 Jun 23:1-8. Epub 2022 Jun 23.

Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon balanced by a counter anti-inflammatory response syndrome. Read More

Sci Rep 2022 Jun 21;12(1):10479. Epub 2022 Jun 21.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

Determining the optimal treatment course for a dermatologic burn wound requires knowledge of the wound's severity, as quantified by the depth of thermal damage. In current clinical practice, burn depth is inferred based exclusively on superficial visual assessment, a method which is subject to substantial error rates in the classification of partial thickness (second degree) burns. Here, we present methods for direct, quantitative determination of the depth extent of injury to the dermal collagen matrix using polarization-sensitive optical coherence tomography (PS-OCT). Read More

Nature 2022 06 15;606(7914):489-493. Epub 2022 Jun 15.

JILA, National Institute of Standards and Technology and the University of Colorado, Boulder, CO, USA.

Entangling microwave-frequency superconducting quantum processors through optical light at ambient temperature would enable means of secure communication and distributed quantum information processing. However, transducing quantum signals between these disparate regimes of the electro-magnetic spectrum remains an outstanding goal, and interfacing superconducting qubits, which are constrained to operate at millikelvin temperatures, with electro-optic transducers presents considerable challenges owing to the deleterious effects of optical photons on superconductors. Moreover, many remote entanglement protocols require multiple qubit gates both preceding and following the upconversion of the quantum state, and thus an ideal transducer should impart minimal backaction on the qubit. Read More

Cureus 2022 May 12;14(5):e24940. Epub 2022 May 12.

General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.

Many surgeons are familiar with small bowel perforation-a breach in the continuity of the bowel wall resulting in spillage of contents into the peritoneal cavity. Usually, patients present with severe abdominal pain, and radiological investigations suggest pneumoperitoneum. However, intestinal perforation secondary to electrocautery used for umbilical granuloma excision is rare. Read More

Int Wound J 2022 Jun 15. Epub 2022 Jun 15.

From Department of Burns and Plastic Surgery, The Forth Medical Center, Chinese PLA General Hospital, Beijing, China.

Platelets exert important roles in burn wound healing and involving in inflammatory regulation and tissue repair. Platelet distribution width (PDW) is an indicator representing platelet morphology and activation. In this study, we try to evaluate the value of PDW in predicting short-term prognosis and cost of paediatrics with partial-thickness thermal burns. Read More

Australas Emerg Care 2022 Jun 7. Epub 2022 Jun 7.

Victorian Adult Burn Service, The Alfred, Melbourne, Australia.

Background: Burn injuries are a leading cause of morbidity that can result in devastating disability and poor quality of life for survivors. This systematic review aimed to synthesise evidence regarding the effect of 20 minutes of cool running water (CRW) within three hours of injury on outcomes of patients with thermal burn injuries.

Methods: This systematic review was conducted in reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Read More

Am J Emerg Med 2022 May 31. Epub 2022 May 31.

Prisma Health-Upstate Department of Emergency Medicine, Greenville, SC, United States of America. Electronic address:

As physicians attempt to "Choose Wisely" and decrease ionizing radiation, the use of Magnetic Resonance Imaging (MRI) has increased. While MRI does not expose patients to ionizing radiation, it does expose patients to specific risks, such as thermal burns. Unfortunately, obese patients are at the highest risk for MRI-related thermal burns. Read More

Burns 2022 May 14. Epub 2022 May 14.

University of Western Australia, Burn Injury Research Unit, School of Biomedical Sciences, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia; Fiona Wood Foundation, 11 Robin Warren Drive, Murdoch, Western Australia 6150, Australia. Electronic address:

Chemical burns can cause deep injury and subsequently significant scarring to the skin. The mechanism and pathophysiology of chemical burns is distinct to thermal burns, and recommended first aid approaches are consequently different. Twenty minutes of cool running water is an effective first aid measure to improve outcomes after thermal burn. Read More

Burns 2022 May 7. Epub 2022 May 7.

Plastic, Reconstructive and Aesthetic Surgery, Private Practice, Barbaros Mah. Akzambak Sok., Uphill Towers, İstanbul, Turkey. Electronic address:

Aim: Burn injuries are one of the most devastating injuries. Saving the zone of stasis decreases burn size, morbidity, and mortality. Tarantula cubensis (TC) increases epithelization of wounds, and increases wound contraction. Read More

Am J Case Rep 2021 Nov 26;22:e934052. Epub 2021 Nov 26.

Division of Physiology and Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

BACKGROUND Burns covering a large skin surface area represent a life-threatening condition due to the release of cytokines and the activation of a systemic inflammatory response, as well as the potential for septic complications. Outcome for these patients is related to the burn surface, age, and coexisting diseases. Although some severity scores are available, such as the Abbreviated Burn Severity Index (ABSI), Baux score, R-Baux score, Boston score, and Belgian Outcome Burn Injury (BOBI) score, none can provide a solid picture of the final outcome. Read More

J Burn Care Res 2022 May 26. Epub 2022 May 26.

Clinical Pharmacist, Department of Pharmacy, Regional One Health, 877 Jefferson Avenue, Memphis, TN 38103, USA.

Age, percent total body surface area burned, and presence of inhalation injury have been used historically in the prediction of mortality in thermally injured patients despite other factors being also being associated with mortality. Recent literature has identified novel factors associated with increased length of stay and may provide a better prediction model for mortality in burn patients. The study objective was to perform a subset analysis of a multitude of known and novel variables for potential association with mortality. Read More

Facial Plast Surg 2022 May 24. Epub 2022 May 24.

Plastic and Reconstructive Surgery, University of Rochester Medical Center, Rochester, United States.

Background: Previous studies have evaluated the effectiveness of bacterial nanocellulose (BNC) for the treatment of thermal injuries, but the synergic effect of platelet-rich plasma (PRP) with BNC-based dressing for burns still requires further investigation. Herein, we evaluated the effectiveness of BNC dressings in the management of facial burns using PRP.

Methods: Patients with second-degree facial burns were treated with BNC-based wound dressings after debridement. Read More

Chempluschem 2022 May;87(5):e202200096

DEVCOM US Army Research Laboratory, Energetics Synthesis & Formulation Branch, Aberdeen Proving Ground, MD 21005.

The synthesis of 3-(nitratoethyl-N-nitramino)-5-(nitratomethyl) isoxazole (C H N O , 1) is presented, and its energetic properties were ascertained and analyzed for energetic applications potential. 1 was found to be a solid without melting behavior, begins to decompose at 140 °C, and has a thermal onset decomposition temperature of 171.5 °C. Read More

J Plast Reconstr Aesthet Surg 2022 Apr 20. Epub 2022 Apr 20.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK; Scar Free Foundation Centre for Conflict Wound Research, University Hospitals Birmingham, Birmingham B15 2WB, UK; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham, Birmingham B15 2WB, UK.

Background: Major thermal injury induces a complex pathophysiological state characterized by burn shock and hypercatabolism. Steroids are used to modulate these post-injury responses. However, the effects of steroids on acute post-burn outcomes remain unclear. Read More

ACS Med Chem Lett 2022 May 14;13(5):833-840. Epub 2022 Apr 14.

Discovery Chemistry, Janssen Research & Development L.L.C., San Diego, California 92121, United States.

Acrylamides are privileged electrophiles used in targeted covalent therapies, often installed at the end of a synthetic sequence due to their reactive nature. Herein, we report several diene-acrylamide adducts with a range of thermal stabilities toward retro-Diels-Alder deprotection of the acrylamide, enabling this masked functionality to be introduced early in a synthetic route and deprotected in a specific temperature range. Through kinetic studies, we identify solvent and structural trends that impact the stability of trimethylsilyl cyclopentadiene (TMS-CP) acrylamide adducts. Read More

Ann Burns Fire Disasters 2022 Mar;35(1):26-35

Clinical Emergency Hospital for Children 'Grigore Alexandrescu', Bucharest, Romania.

Burns in neonates is a unique pathology that poses management challenges, as, besides treating the burn injury, the medical team needs to be familiar with the unique physiology of the newborn. This study aimed to review our center's experience with the management of neonatal burns. A 7-year retrospective study of neonatal burns managed at a tertiary national referral unit in Bucharest, Romania, was performed. Read More

Ann Burns Fire Disasters 2022 Mar;35(1):68-73

Hopital Saint Louis, Paris, France.

Hands are one of the most often burnt parts of the body. Deep palmar burns are often the result of an electrical burn or a thermal burn from grasping a hot item. With a deep burn, joints, vasculo-nervous pedicles, tendons or bones can become exposed and lead to amputation. Read More

Ann Burns Fire Disasters 2022 Mar;35(1):46-54

VM Medical College & Safdarjung Hospital, Delhi, India.

Optimal treatment of sepsis in burned patients depends on early diagnosis and includes prompt administration of antimicrobials as well as management of hemodynamic alterations and other organ dysfunctions. The role of red blood cell distribution width (RDW) and platelet indices in prognosticating and identifying sepsis in acute burn patients is studied. This study was done as a prospective study over 18 months, including patients in the age group >18 or <60 years, with burns >20% and <70% TBSA, burn time to resuscitation time 24 hours or less and with thermal and scald burns. Read More

Undersea Hyperb Med 2022 Second Quarter;49(2):233-248

Memorial Care Long Beach Memorial Medical Center, Long Beach, California U.S.

Acute traumatic ischemias are an array of disorders that range from crush injuries to compartment syndromes, from burns to frostbite and from threatened flaps to compromised reimplantations. Two unifying components common to these conditions are a history of trauma be it physical, thermal, or surgical coupled with ischemia to the traumatized tissues. Their pathophysiology resolves around the self-perpetuating cycle of edema and ischemia, and their severity represents a spectrum from mild, almost non-existent, to tissue death. Read More

BMC Pediatr 2022 May 14;22(1):281. Epub 2022 May 14.

Department of Neonatology, Hebei Petro China Central Hospital, Langfang, 065000, Hebei, China.

Background: Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89. Read More

Burns 2022 Apr 22. Epub 2022 Apr 22.

Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. Electronic address:

Background: Facial burns frequently occur in occupational or household accidents. While dysphagia and dysphonia are known sequelae, little is known about impaired smell and taste after facial burns.

Methods: In a prospective observational controlled study, we evaluated hyposmia via the Sniffin' Stick Test (SnS), hypogeusia via a taste strip test, and dysphonia and dysphagia via validated questionnaires acutely and one-year after burn, respectively. Read More

Biomed Opt Express 2022 Apr 3;13(4):1855-1868. Epub 2022 Mar 3.

State University of New York at Stony Brook, THz Biophotonics Laboratory, Department of Biomedical Engineering, 101 Nicolls Rd., Stony Brook, NY 11794, USA.

Thermal injuries can occur due to direct exposure to hot objects or liquids, flames, electricity, solar energy and several other sources. If the resulting injury is a deep partial thickness burn, the accuracy of a physician's clinical assessment is as low as 50-76% in determining the healing outcome. In this study, we show that the Terahertz Portable Handheld Spectral Reflection (THz-PHASR) Scanner combined with a deep neural network classification algorithm can accurately differentiate between partial-, deep partial-, and full-thickness burns 1-hour post injury, regardless of the etiology, scanner geometry, or THz spectroscopy sampling method (ROC-AUC = 91%, 88%, and 86%, respectively). Read More

Tidsskr Nor Laegeforen 2022 05 2;142(7). Epub 2022 May 2.

Seksjon for plastikk- og rekonstruktiv kirurgi, Universitetssykehuset Nord-Norge.

Background: Breast reconstruction using free flaps based on the lower abdominal tissue is a common procedure. Postoperatively, the blood supply and innervation of the flap will be altered due to denervation. The case presented here illustrates the resulting increased sensitivity to heat exposure. Read More

Int J Legal Med 2022 Jul 30;136(4):1133-1148. Epub 2022 Apr 30.

Department of Medical Biology, Section Clinical Anatomy and Embryology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.

To investigate the differences between pre- and post-fire fractures, 30 human forearm bones were subjected to either blunt-force impact, burning, or both. Bones, covered in soft tissue and wrapped in clothing, were burned in a reconstructed house fire. The burning context and dynamics led to differential burning, that was equal amongst the three groups. Read More

Clin Rehabil 2022 07 25;36(7):995-996. Epub 2022 Apr 25.

37523Bursa Uludağ University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Bursa, Turkey.

Burns 2022 Mar 29. Epub 2022 Mar 29.

Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, South Korea. Electronic address:

Purpose: Hypertrophic scars that occur after burns are less flexible and less elastic than normal skin. Objective measurement tools are required to assess hypertrophic scars after thermal injury. Cutometer® MPA 580 has been widely used for evaluating the properties of hypertrophic scars. Read More

J Clin Med 2022 Apr 18;11(8). Epub 2022 Apr 18.

Chair and Department of Didactics and Medical Simulation, Medical University of Lublin, 20-093 Lublin, Poland.

Burns are one of the most common causes of home injuries, characterized by serious damage to the skin and causing the death of affected tissues. In this review, we intended to collect information on the pathophysiological effects of burns in pediatric patients, with particular emphasis on local and systemic responses. A total of 92 articles were included in the review, and the time range of the searched articles was from 2000 to 2021. Read More

APMIS 2022 Apr 19. Epub 2022 Apr 19.

Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.

Acute wounds, such as thermal injury, and chronic wounds are challenging for patients and the healthcare system around the world. Thermal injury of considerable size induces immunosuppression, which renders the patient susceptible to wound infections, but also in other foci like the airways and urinary tract. Infected thermal lesions can progress to chronic wounds with biofilm making them more difficult to treat. Read More

Sci Rep 2022 04 19;12(1):6414. Epub 2022 Apr 19.

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Defense Road Campus, Lahore, Pakistan.

Antimicrobials used to treat burn wound infections have become multidrug-resistant, thus delaying wound healing. When combined with silver nanoparticles, antibiotics create a multifaceted antibacterial mechanism of action to which bacteria are incapable of developing resistance. Similarly, the amniotic membrane has been found to lower the bacterial number. Read More